ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII0642 check: MH TU KOG0903 Intracellular trafficking, secretion, and vesicular transport Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion
r_klactIII0642 check: MH TU KOG0903 Signal transduction mechanisms Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII0642 211012 213879 956
(956 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL267w [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 1046 0.0
SPAC22E12.16c [TU] KOG0903 Phosphatidylinositol 4-kinase involve... 455 e-127
At5g09350 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 285 3e-76
At5g64070 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 280 1e-74
Hs4505809 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in... 265 3e-70
CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 250 8e-66
SPBC577.06c [T] KOG0902 Phosphatidylinositol 4-kinase 191 5e-48
ECU03g1100 [TU] KOG0903 Phosphatidylinositol 4-kinase involved i... 190 1e-47
YLR305c [T] KOG0902 Phosphatidylinositol 4-kinase 184 7e-46
CE23035 [T] KOG0902 Phosphatidylinositol 4-kinase 170 8e-42
ECU11g0450 [T] KOG0902 Phosphatidylinositol 4-kinase 168 3e-41
7290340 [T] KOG0902 Phosphatidylinositol 4-kinase 166 1e-40
Hs4505807 [T] KOG0902 Phosphatidylinositol 4-kinase 164 6e-40
Hs17105400 [T] KOG0902 Phosphatidylinositol 4-kinase 164 6e-40
At1g49340 [T] KOG0902 Phosphatidylinositol 4-kinase 151 5e-36
7291958 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 142 2e-33
At1g51040 [T] KOG0902 Phosphatidylinositol 4-kinase 138 5e-32
Hs4505801 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invol... 132 3e-30
Hs18589256 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invo... 132 3e-30
Hs22068531 [T] KOG0902 Phosphatidylinositol 4-kinase 130 7e-30
At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invol... 124 7e-28
YLR240w [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 115 4e-25
HsM4505803 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 114 9e-25
Hs21237725 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 114 9e-25
CE24760 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 114 9e-25
CE24759 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 114 9e-25
SPAC458.05 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invo... 113 2e-24
7300643 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subu... 112 3e-24
Hs4505799 [T] KOG0905 Phosphoinositide 3-kinase 112 4e-24
Hs4758924 [T] KOG0905 Phosphoinositide 3-kinase 109 2e-23
CE05832 [T] KOG0905 Phosphoinositide 3-kinase 108 5e-23
7291607 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 106 2e-22
Hs15451926 [T] KOG0905 Phosphoinositide 3-kinase 105 4e-22
Hs5453894 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic su... 104 6e-22
7294673 [T] KOG0905 Phosphoinositide 3-kinase 104 6e-22
Hs5453892 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic su... 103 2e-21
Hs19923289 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic s... 102 4e-21
CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subu... 94 1e-18
YBL088c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 68 8e-11
SPCC23B6.03c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in ... 66 3e-10
7299977 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 62 3e-09
ECU10g0590 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invo... 61 9e-09
SPBC30D10.10c [L] KOG0891 DNA-dependent protein kinase 58 8e-08
SPBC216.05 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 58 8e-08
7297995 [L] KOG0891 DNA-dependent protein kinase 55 4e-07
Hs4502325 [TBLD] KOG0890 Protein kinase of the PI-3 kinase famil... 55 5e-07
Hs22041606 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 55 5e-07
YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 53 2e-06
CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 53 3e-06
CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 53 3e-06
SPBC216.07c [L] KOG0891 DNA-dependent protein kinase 52 3e-06
At5g40820 [TBLD] KOG0890 Protein kinase of the PI-3 kinase famil... 52 3e-06
Hs4826730 [L] KOG0891 DNA-dependent protein kinase 52 6e-06
CE28813 [L] KOG0891 DNA-dependent protein kinase 52 6e-06
CE07705 [L] KOG0891 DNA-dependent protein kinase 52 6e-06
Hs20336203 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in te... 51 7e-06
Hs20336199 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in te... 51 7e-06
At1g50030 [L] KOG0891 DNA-dependent protein kinase 51 1e-05
>YNL267w [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1066
Score = 1046 bits (2706), Expect = 0.0
Identities = 577/1051 (54%), Positives = 707/1051 (66%), Gaps = 113/1051 (10%)
Query: 12 LLKYINSSNFTLYNNIEYLTRYADNIGIHFYLCEKLLSFPHKELQFYIPQLVQILLTMET 71
LLK INSS FTL+N +E L ++++NIGIH+YLC+KL +FPH ELQFYIPQLVQ+L+TMET
Sbjct: 23 LLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMET 82
Query: 72 ESLALEEILLRLSSENPHFALITFWQLQALLGDLAHDPTSYSFQVARRVLNHLQFILFNT 131
ES+ALE++LLRL +ENPHFAL+TFWQLQALL DL+ DP SY FQVARRVLN+LQ LFNT
Sbjct: 83 ESMALEDLLLRLRAENPHFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNT 142
Query: 132 TRKND-NEKINENIAPALILCSMVTTGFAFPGLLEHTKPLIKSQGRRQKSYVFKLAKHAM 190
+ +D N KI+EN+APAL+L SM+ + AFP L E TKPL++SQGRRQK++VFKLA+ AM
Sbjct: 143 SSGSDKNVKIHENVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAM 202
Query: 191 XXXXXXXXXXXXXANXXXXXX---XXXXXVTNIANVDLVDTVTTKEDVTYKKKRQDSIS- 246
N T + +DL+D + TKED +++K R +
Sbjct: 203 KDFTKNMTLKNTLLNKKTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKL 262
Query: 247 --DLSFDMVDDIGEKLF------------------------------EDHISNSIKLPKR 274
D+ D+ + + E+ + ISN+ K
Sbjct: 263 DFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDG 322
Query: 275 RDTSYIHAVYKNPPITE---------------------EEYTNSMXXXXXXXXXXXXXXX 313
YI +N E + +T+SM
Sbjct: 323 NKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASS 382
Query: 314 XXAK--------KSMDAIRETTTNPSSYNESKRQMIDVTHLSTTKKIKLLKVNYFHCCTQ 365
+ S R+ N N S Q ID++ LSTT KIK+LK NYF C TQ
Sbjct: 383 ASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQ 442
Query: 366 FAIALESISQRLAQVPPEARLSALRAELSILNRDLPAEVDIPELLPVNKKGKLHKLIKIS 425
FAIALE+ISQRLA+VP EARLSALRAEL +LNRDLPAEVDIP LLP NKKGKLHKL+ I+
Sbjct: 443 FAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTIT 502
Query: 426 ANEAQVLNSAEKVPYLLFIEFLKDDFDFDPTSEQNIKLLE--NNPRSSYIFDLSYV--KQ 481
ANEAQVLNSAEKVPYLL IE+L+D+FDFDPTSE N +LL+ + + IFDL+Y+ K+
Sbjct: 503 ANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKE 562
Query: 482 NNAP------------------------FKANMPLETSSGS-----------ANQEMDLA 506
NN N L ++S S N+E DL
Sbjct: 563 NNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLG 622
Query: 507 DVSMVKLTNQSEAENYRHELMMKNAKTVPVIPPDSHTRGSELDFVADLQEAT-ERLTDIK 565
D+SMVK+ N+++ E YR+ L++++A VP++P DS R EL+F ++L E E + K
Sbjct: 623 DMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSK 682
Query: 566 LHRDSSDDLATQMRVSAMMXXXXXXXXXXXXXXXNQIRAKIIASMQEMQDKFGYRDLEAI 625
+D LA QMRVSA+M QIRA+II+SM+E+QDKFGY DLEA+
Sbjct: 683 NIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLEAL 742
Query: 626 HGMAGERKLENDFKTGGLTTSNDKTSTSYLGEDWNAKKEKIRKSSEFGHLPNWDLCSVIS 685
HGMAGERKLEND TGG+ TSYLGEDW KKE+IRK+SE+GH NWDLCSVI+
Sbjct: 743 HGMAGERKLENDLMTGGI-------DTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIA 795
Query: 686 KSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHSIK 745
K+GDDLRQEAFA Q+IQAMA IW KE V VWVK+M ILITS++TGLVETITNA+SVHSIK
Sbjct: 796 KTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIK 855
Query: 746 KSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLR 805
K+LT MIE+ LD+KG IASL DHF R +G+PNGFK+R AQDNFASSLAAYS+ICYLL+
Sbjct: 856 KALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQ 915
Query: 806 IKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKK 865
+KDRHNGNIMIDNEGHV HIDFGFMLSNSPGSVGFEAAPFKLTYEY+E++GG E E FKK
Sbjct: 916 VKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKK 975
Query: 866 FVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECDE 925
FVEL K++FKALRKYAD IVS+CEIMQKD++QPCF AG+QTSVQLRQRF L+LS++E D+
Sbjct: 976 FVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDD 1035
Query: 926 FVENVLISKSLGSRYTRLYDHFQLLTQGIYS 956
FVEN LI KSLGS YTR+YD FQL+TQGIYS
Sbjct: 1036 FVENFLIGKSLGSIYTRIYDQFQLITQGIYS 1066
>SPAC22E12.16c [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 851
Score = 455 bits (1171), Expect = e-127
Identities = 262/625 (41%), Positives = 388/625 (61%), Gaps = 30/625 (4%)
Query: 346 LSTTKKIKLLKVNYFHCCTQFAIALESISQRLAQVPPEARLSALRAELSILNRDLPAEVD 405
LS ++ ++L+ NYF QF AL+ IS RL VP +ARLS+LRAEL++LN +LPA+V+
Sbjct: 242 LSIDEQRRVLRSNYFQQEIQFLFALQDISIRLIIVPRQARLSSLRAELALLNNNLPADVN 301
Query: 406 IPELLPVNKKGKLHKLIKISANEAQVLNSAEKVPYLLFIEFLKDDFDFDPTSEQNI---- 461
IP L +K+ HK+++I EA +LNSAE+VPYL+ +E L + F+P S++N
Sbjct: 302 IPLLRSYHKEVS-HKIVRIDPKEATILNSAERVPYLIMVEVLSGELSFEPQSKKNKAKVQ 360
Query: 462 KLLENNPRSSYIFDLSYVKQNNAPFKANMPLETSSGSANQEMDLADVSMVKLTNQSEAEN 521
K++ + + FDL+ V P+ N+ T + + E + D+SM L +
Sbjct: 361 KIVSHKNQRKRWFDLTDVD----PY-TNLQDSTDNDISESESEGGDLSMSPLIKGLVPDT 415
Query: 522 YRHELMMKNAKTVPVIPPDSHTRGSELDFVADLQEATERLTDIKLHRDSSDDLATQMRVS 581
+ V + P SH R +++ ++ ++ +K + + ++ +MR +
Sbjct: 416 LSLSKSFSSFGNVSLQVPSSH-RDTDVVLLSGRHSDSDGNGALKRSKIYASEITARMRAA 474
Query: 582 A-MMXXXXXXXXXXXXXXXNQIRAKIIASMQEMQDKFGYRDLEAIHGMAGERKLENDFKT 640
A M+ +I+ II MQ ++++ + +I+ ++ + D +
Sbjct: 475 ATMLSQLDAEGSRRPKAETERIKNSIILDMQRLEEE--RLNEPSIYPVSVDISCAEDLRF 532
Query: 641 GGLTTS------NDKTSTSYLGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQE 694
G T D S + EDW AKKE+IRKSS +GH PNWDL SVI K+G DLRQE
Sbjct: 533 GKETQKAERKGDRDDPSAATFQEDWYAKKERIRKSSPYGHYPNWDLVSVIVKTGADLRQE 592
Query: 695 AFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIE 754
FACQLI A +W + VWV++M IL+T ++GL+ETITNAISVHSIKK+LT + E
Sbjct: 593 TFACQLIYAFQRVWLECKEKVWVRRMKILVTGDNSGLIETITNAISVHSIKKNLTKQLRE 652
Query: 755 ----EGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRH 810
+G + K ++ +L D+F + +GDPN ++R AQ NF SL AYSII YLL++KDRH
Sbjct: 653 AELAQGKIAGK-NVVTLKDYFIKQFGDPNSSRYRQAQTNFLQSLVAYSIISYLLQLKDRH 711
Query: 811 NGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELC 870
NGN++ID+EGH++HIDFGF+L+N+PG+VGFE+APFKLT +Y+E++ + F ++ L
Sbjct: 712 NGNVLIDSEGHIIHIDFGFLLTNTPGNVGFESAPFKLTADYLEIL----DDRFDEYRSLM 767
Query: 871 KAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECDEFVENV 930
KAAFK++RK AD I+ L E+MQ +S PCF+AG+ TS QL QRF L+L D+ECD+FV+ +
Sbjct: 768 KAAFKSVRKNADQIILLVEVMQNNSTMPCFRAGENTSAQLLQRFQLQLGDKECDDFVD-L 826
Query: 931 LISKSLGSRYTRLYDHFQLLTQGIY 955
LI K+ S +TRLYD FQ +T GIY
Sbjct: 827 LIQKANCSVWTRLYDLFQNITNGIY 851
Score = 149 bits (375), Expect = 3e-35
Identities = 73/179 (40%), Positives = 119/179 (65%), Gaps = 3/179 (1%)
Query: 1 MESTDDRNPDILLKYINSSNFTLYNNIEYLTRYADNIGIHFYLCEKLLSFPHKELQFYIP 60
M S++ N ++LL++ S++FT + YL+RY +NIGIH +LCEKL +FP++E++F+IP
Sbjct: 1 MPSSNSGN-ELLLRFFESAHFTSQLCVAYLSRYPNNIGIHHFLCEKLATFPYEEIEFFIP 59
Query: 61 QLVQILLTMETESLALEEILLRLSSENPHFALITFWQLQALLGDLAHDPTSYSFQVARRV 120
QL+ ++L ++ES+ALEE ++ +N ALITFW LQA + DL P S F++ +R+
Sbjct: 60 QLIHLVLNKDSESVALEEFIISQCEQNTQCALITFWYLQAHMVDLGLQPHSSCFKICKRL 119
Query: 121 LNHLQFILFNTTRK--NDNEKINENIAPALILCSMVTTGFAFPGLLEHTKPLIKSQGRR 177
N +Q ++F ++ +KI+EN+ PALIL ++ G P LL+ P+ +QGR+
Sbjct: 120 YNRIQILVFMSSSSLIQSQQKISENVTPALILSGIMLGGVCVPELLKKAGPIAIAQGRK 178
>At5g09350 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1116
Score = 285 bits (728), Expect = 3e-76
Identities = 208/604 (34%), Positives = 306/604 (50%), Gaps = 47/604 (7%)
Query: 360 FHCCTQFAIALESISQRLAQV-PPEARLSALRAELSILNRDLP-AEVDIPELLPVNKKGK 417
+H +F AL S L + P E R +ALR ++ +N L AE P+ +
Sbjct: 550 YHESLEFVHALCETSYDLVDIFPIEDRKTALRESIAEINSHLAQAETTGGICFPMGRG-- 607
Query: 418 LHKLIKISANEAQVLNSAEKVPYLLFIEFLKDDFDFDP-TSEQNIKLLENN-PRSSYIFD 475
+++++ I +E +LNS EKVPY++ +E LK + T+ ++KL + P ++
Sbjct: 608 VYRVVNIPEDEYVLLNSREKVPYMICVEVLKAETPCGAKTTSTSLKLSKGGIPLANGDAF 667
Query: 476 LSYVKQNNAPFKANMPLETSSGSANQEMDLADVSMVKLTNQSEAENYRHELMMKNAKTVP 535
L + P PL T+ D +S V+ +Q A ++ E+ + NA
Sbjct: 668 L------HKPPPWAYPLSTAQEVYRNSADRMSLSTVEAIDQ--AMTHKSEVKLVNACLSV 719
Query: 536 VIPPDSHTRGSELDFVADLQEATER-LTDIKLHRDSSDDLATQMRVSAMMXXXXXXXXXX 594
+S+T+ L+ E L ++L + L +
Sbjct: 720 ETHSNSNTKSVSSGVTGVLRTGLESDLEWVRLVLTADPGLRMESITDPKTPRRKEHRRVS 779
Query: 595 XXXXXNQIRAKIIASMQEMQDKFGYRDLEAIHGMAGERKLENDFKTGGLTTSNDKTSTSY 654
++RA A+ E + G + GG+ + D S
Sbjct: 780 SIVAYEEVRAA--AAKGEAPPGL------PLKGAGQDSSDAQPMANGGMLKAGDALS--- 828
Query: 655 LGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFACQLIQAMAAIWSKENVG 714
GE W K+ +IRK S +G+LP WDL S+I KSGDD RQE A QLI I+ + +
Sbjct: 829 -GEFWEGKRLRIRKDSIYGNLPGWDLRSIIVKSGDDCRQEHLAVQLISHFFDIFQEAGLP 887
Query: 715 VWVKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRV 774
+W++ +L+TSS+T L+ETI + S+HSIK +I SL D F
Sbjct: 888 LWLRPYEVLVTSSYTALIETIPDTASIHSIKSRYP-------------NITSLRDFFDAK 934
Query: 775 YGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNS 834
+ + N F+ AQ NF S+A YS++CYLL+IKDRHNGN+++D EGH++HIDFGFMLSNS
Sbjct: 935 FKE-NSPSFKLAQRNFVESMAGYSLVCYLLQIKDRHNGNLLMDEEGHIIHIDFGFMLSNS 993
Query: 835 PGSVGFEAAPFKLTYEYVEVMG----GSESETFKKFVELCKAAFKALRKYADHIVSLCEI 890
PG V FE+APFKLT E +EVM G SE F F LC F RK+A+ I+ L E+
Sbjct: 994 PGGVNFESAPFKLTRELLEVMDSDAEGLPSEFFDYFKVLCIQGFLTCRKHAERIILLVEM 1053
Query: 891 MQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECDEFVENVLISKSLGSRYTRLYDHFQLL 950
+Q DS PCF+ G +T LR+RFHL L++E+C V + LIS SL + TR YD++Q +
Sbjct: 1054 LQ-DSGFPCFKGGPRTIQNLRKRFHLSLTEEQCVSLVLS-LISSSLDAWRTRQYDYYQRV 1111
Query: 951 TQGI 954
GI
Sbjct: 1112 LNGI 1115
>At5g64070 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1121
Score = 280 bits (715), Expect = 1e-74
Identities = 211/620 (34%), Positives = 312/620 (50%), Gaps = 75/620 (12%)
Query: 360 FHCCTQFAIALESISQRLAQV-PPEARLSALRAELSILNRDLP-AEVDIPELLPVNKKGK 417
+H +F AL S L + P E R LR L+ +N L AE+ P+ +
Sbjct: 551 YHESLEFVQALCETSYGLVDIFPIEDRKIGLRESLAEINFHLSEAEITGGICFPMGRG-- 608
Query: 418 LHKLIKISANEAQVLNSAEKVPYLLFIEFLKDDFDFDPTSEQNIKL-------------L 464
+ +++ I +E +LNS EK PY++ +E LK + S + KL L
Sbjct: 609 VFRVVHIPEDECILLNSREKAPYMISVEVLKAETPSAKESSNSQKLSKGGIPLANGDAFL 668
Query: 465 ENNPRSSY-IFDLSYVKQNNAPFKANMPLETSSGSANQEMDLADVSMVKLTNQSEAENYR 523
+ P +Y ++ V +N+A M L T+ + +Q M VKL N S + R
Sbjct: 669 QKPPPWAYPLWTTQEVYRNSAD---RMSLSTAQ-AIDQAMTPKSEVKVKLVNVSLSVEDR 724
Query: 524 HELMMKNAKTVPVIPPDSHTRG--SELDFVADLQEATERLTDIKLHRDSSDDLATQMRVS 581
+ + + ++ G ++L++V + A D L +S D + +
Sbjct: 725 TSALESFGDPIDDVLGEAPRTGLNNDLEWVRVVVTA-----DPGLRMESIPDPSVPRK-- 777
Query: 582 AMMXXXXXXXXXXXXXXXNQIRAKIIASMQEMQDKFGYRDLEAIHGMAGERKLENDFK-- 639
R +M+E++ + + G + +D +
Sbjct: 778 -----------------KEHRRVPSTVAMEEVRAAAAKGEAPPGLPLKGAGQDSSDAQPR 820
Query: 640 -TGGLTTSNDKTSTSYLGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFAC 698
GG+ D S GE W K+++IRK+S +G LP WDL S+I KSGDD RQE A
Sbjct: 821 ANGGMLKEGDALS----GELWEGKRDRIRKASIYGKLPGWDLRSIIVKSGDDCRQEHLAV 876
Query: 699 QLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSL 758
QLI I+ + + +W++ +L+TSS+T L+ETI + S+HSIK
Sbjct: 877 QLISHFYDIFQEAGLPLWLRPYEVLVTSSYTALIETIPDTASIHSIKSRYP--------- 927
Query: 759 DEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDN 818
+I SL D F Y + N F+ AQ NF S+A YS++CYLL++KDRHNGN+++D
Sbjct: 928 ----NITSLRDFFVAKYKE-NSPSFKLAQRNFVESMAGYSLVCYLLQVKDRHNGNLLLDE 982
Query: 819 EGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVM----GGSESETFKKFVELCKAAF 874
EGH++HIDFGFMLSNSPG V FE+APFKLT E +EVM G SE F F LC F
Sbjct: 983 EGHIIHIDFGFMLSNSPGGVNFESAPFKLTRELLEVMDSDADGVPSEFFDYFKVLCIQGF 1042
Query: 875 KALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECDEFVENVLISK 934
RK+A+ I+ L E++Q DS PCF+ G +T LR+RFHL L++E+C V + LIS
Sbjct: 1043 LTCRKHAERIILLVEMLQ-DSGFPCFKGGPRTIQNLRKRFHLSLTEEQCVSLVLS-LISS 1100
Query: 935 SLGSRYTRLYDHFQLLTQGI 954
SL + TR YD++Q + GI
Sbjct: 1101 SLDAWRTRQYDYYQRVLNGI 1120
>Hs4505809 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 828
Score = 265 bits (677), Expect = 3e-70
Identities = 133/300 (44%), Positives = 189/300 (62%), Gaps = 17/300 (5%)
Query: 655 LGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFACQLIQAMAAIWSKENVG 714
L E W K +IR+ S +GHLPNW L SVI K GDDLRQE A Q+++ + +IW +E V
Sbjct: 545 LKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVP 604
Query: 715 VWVKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRV 774
+W+K IL+ S+ +G++E + NA+S+H +KK SLLD+F +
Sbjct: 605 LWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQL---------------SLLDYFLQE 649
Query: 775 YGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNS 834
+G F AQ NF S A Y ++CYLL++KDRHNGNI++D EGH++HIDFGF+LS+S
Sbjct: 650 HGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSS 709
Query: 835 PGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKD 894
P ++GFE + FKLT E+V+VMGG + + F + L A RK+ D +V + EIMQ+
Sbjct: 710 PRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQG 769
Query: 895 SLQPCFQAGDQTSVQLRQRFHLELSDEECDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
S PCF G T L++RFH+ +++E+ VE ++ S+ S T+LYD FQ LT GI
Sbjct: 770 SQLPCFH-GSSTIRNLKERFHMSMTEEQLQLLVEQ-MVDGSMRSITTKLYDGFQYLTNGI 827
Score = 60.1 bits (144), Expect = 2e-08
Identities = 47/152 (30%), Positives = 79/152 (51%), Gaps = 17/152 (11%)
Query: 323 IRETTTNPSSYNESKRQMIDVTHL--STTKKIKLLKVNYFHCCTQFAIALESISQRLAQV 380
++ T +NP NE + + S + ++L +F +L +I +RLA +
Sbjct: 301 LKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPER------EFIKSLMAIGKRLATL 354
Query: 381 PP-EARLSALRAELSILNRDLPAEVDIPELLPVNKKGKLHKLIKISANEAQVLNSAEKVP 439
P E + L +ELS+LN LPA V +P G H ++++ +A VLNS +K P
Sbjct: 355 PTKEQKTQRLISELSLLNHKLPARVWLPTA------GFDHHVVRVPHTQAVVLNSKDKAP 408
Query: 440 YLLFIEFLKDDFDFDPTSEQNIKLLENNPRSS 471
YL+++E L+ + +FD TS ++ EN RS+
Sbjct: 409 YLIYVEVLECE-NFDTTSVP-ARIPENRIRST 438
>CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 604
Score = 250 bits (638), Expect = 8e-66
Identities = 132/305 (43%), Positives = 184/305 (60%), Gaps = 5/305 (1%)
Query: 651 STSYLGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFACQLIQAMAAIWSK 710
S + E W KK +IR SS + + WDL VI K+GDDL QEAFA QL+ +W +
Sbjct: 305 SIAVFAESWAEKKARIRGSSRYENHQKWDLIPVIVKTGDDLSQEAFAQQLLFTFKDLWHE 364
Query: 711 ENVGVWVKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSLDEKGDIASLLDH 770
E V ++++ I+ S GL+E + + +S+H IK+ LT G++ SL H
Sbjct: 365 EGVPLYLRPYKIVCIGSDAGLIEPVLDTLSLHQIKRHLTNVFRMNGNVTTP----SLKHH 420
Query: 771 FSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFM 830
F V+G N + +AQ NF S AAYS++ Y L++KDRHNGNI++D +GH++HID+GF+
Sbjct: 421 FENVFGPVNSETYVNAQKNFIQSTAAYSLVSYYLQLKDRHNGNILLDMDGHLIHIDYGFL 480
Query: 831 LSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEI 890
LS+SP ++GFE APFKLT E ++VMGG +S+ F F L A RK+ IVSL EI
Sbjct: 481 LSSSPRNLGFETAPFKLTTEIIDVMGGIDSDMFLYFKSLLLRGLMAARKHHRRIVSLAEI 540
Query: 891 MQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECDEFVENVLISKSLGSRYTRLYDHFQLL 950
M S CF+AG +T L RFH+ +DE+ + V+ L+ S S TR YD FQ
Sbjct: 541 MSAGSKMQCFRAGAETVRALEARFHVSSTDEQLQQLVD-TLVEGSRDSYTTRFYDSFQYY 599
Query: 951 TQGIY 955
T GI+
Sbjct: 600 TNGIH 604
>SPBC577.06c [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1877
Score = 191 bits (485), Expect = 5e-48
Identities = 109/274 (39%), Positives = 157/274 (56%), Gaps = 19/274 (6%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
S I K GDD RQ+ QLI I++ + V++ + T+ G+++ + N IS
Sbjct: 1620 SAIFKVGDDCRQDVLTLQLIAMFKNIFNSVGLDVYLFPYRVTATNPGCGVIDVLPNCISR 1679
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
+ + + L D+F +GD + F+ A+ NF S+AAYS+I
Sbjct: 1680 DMLGREA---------------VNGLYDYFRTKFGDEDSIAFQKARSNFVQSMAAYSVIT 1724
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGS-ES 860
YLL+ KDRHNGNIMID++GH++HIDFGF+ +PG + FE+APFKLT E + VMGGS +S
Sbjct: 1725 YLLQFKDRHNGNIMIDDQGHILHIDFGFIFDIAPGGITFESAPFKLTTEMIAVMGGSNKS 1784
Query: 861 ETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSD 920
+ F+ F ELC AF A R YA +I E+M DS PCF+ G T +RF L L++
Sbjct: 1785 QPFQWFQELCVKAFLACRPYAHYICQAVEVM-LDSGLPCFK-GQLTITHCLERFALNLNE 1842
Query: 921 EECDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
+ F+ + LI +S ++ T +YD FQ T GI
Sbjct: 1843 RQASTFMLH-LIEQSYANKRTLMYDQFQKATNGI 1875
>ECU03g1100 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in
intracellular trafficking and secretion
Length = 711
Score = 190 bits (482), Expect = 1e-47
Identities = 106/297 (35%), Positives = 168/297 (55%), Gaps = 18/297 (6%)
Query: 657 EDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVW 716
+ W KK ++R++S F + W SVI K+G+ L QE A Q++ M IW +E +W
Sbjct: 431 DGWMLKKAELRRTSLFKEMAGWMAESVIVKTGNSLMQELMAYQVLCEMKRIWREEGSPIW 490
Query: 717 VKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYG 776
++ I + S +G+VET+ +A+S+H IKK + + + SL ++F+ +
Sbjct: 491 IRAYQIYLISDTSGIVETVVDAMSIHKIKKKMMS----------ENKNYSLRNYFADSF- 539
Query: 777 DPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPG 836
+ N K++ NF SL YS+ Y+L++KDRHNGNIMID +GH+VH+DFGF++ PG
Sbjct: 540 ELNSAKYKSCLRNFLYSLVGYSLATYILQVKDRHNGNIMIDGQGHIVHVDFGFVMGGHPG 599
Query: 837 SVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSL 896
EAAPFK + EY+E++G + +F +L + LRK++ + + E M S
Sbjct: 600 FYCVEAAPFKFSKEYLELLG----DLVDEFKDLFLRGYMELRKHSSRLFRIIETMPGASG 655
Query: 897 QPCFQAGDQTSVQLRQRFHLELSDEECDEFVENVLISKSLGSRYTRLYDHFQLLTQG 953
CF + + + RF L+L++E +E V LI+KS S T LYD +Q + G
Sbjct: 656 AECFNKRELQN--FKDRFRLDLTEERVEEHV-LYLINKSFNSMGTGLYDSYQYFSYG 709
>YLR305c [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1900
Score = 184 bits (466), Expect = 7e-46
Identities = 106/274 (38%), Positives = 156/274 (56%), Gaps = 19/274 (6%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+ I K GDD RQ+ A QLI IWS + V+V + T+ G+++ + N++S
Sbjct: 1643 AAIFKVGDDCRQDVLALQLISLFRTIWSSIGLDVYVFPYRVTATAPGCGVIDVLPNSVSR 1702
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
+ + + L ++F+ +G+ + +F++A++NF SLA YS+I
Sbjct: 1703 DMLGREA---------------VNGLYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVIS 1747
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGS-ES 860
YLL+ KDRHNGNIM D++GH +HIDFGF+ PG + FEA PFKLT E V+VMGGS ++
Sbjct: 1748 YLLQFKDRHNGNIMYDDQGHCLHIDFGFIFDIVPGGIKFEAVPFKLTKEMVKVMGGSPQT 1807
Query: 861 ETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSD 920
+ F ELC A+ A R + + I+ M L PCF+ G +T LR RF + +D
Sbjct: 1808 PAYLDFEELCIKAYLAARPHVEAIIECVNPMLGSGL-PCFK-GHKTIRNLRARFQPQKTD 1865
Query: 921 EECDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
E +++ LI KS S +T+ YD FQ LT GI
Sbjct: 1866 HEAALYMK-ALIRKSYESIFTKGYDEFQRLTNGI 1898
>CE23035 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 2121
Score = 170 bits (431), Expect = 8e-42
Identities = 104/269 (38%), Positives = 158/269 (58%), Gaps = 22/269 (8%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+ I K GDD+RQ+ A QL+Q M +W+ + V V ++ TS G++E + N+ S
Sbjct: 1865 AAIFKVGDDVRQDMLALQLMQLMKNVWAGLGLPVRVFPYRVVATSPGCGVIECVPNSKS- 1923
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
L + D L ++F YGD + F+ A+ NF S+AAYS+
Sbjct: 1924 -------------RDQLGRQTDFG-LYEYFKTQYGDESSETFQEARRNFVRSMAAYSVFS 1969
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP-GSVGFEAAPFKLTYEYVEVMGGS-E 859
+LL+IKDRHNGNIMID +GH++HIDFGFM +SP G++GFE FKL+ E V +MGG E
Sbjct: 1970 FLLQIKDRHNGNIMIDLDGHIIHIDFGFMFESSPGGNLGFE-PDFKLSEEMVAIMGGKME 2028
Query: 860 SETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELS 919
+ F++F LC A+ A+R Y VSL +M D+ PCF+ +T QLR RF E++
Sbjct: 2029 AAPFRQFASLCVHAYLAVRPYHKSFVSLVSLM-LDTHLPCFRG--KTINQLRARFAPEMN 2085
Query: 920 DEECDEFVENVLISKSLGSRYTRLYDHFQ 948
+++ +++ +V+ + L R +++YD Q
Sbjct: 2086 EKDAAKYMYSVITNCFLNIR-SKMYDQLQ 2113
>ECU11g0450 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1433
Score = 168 bits (426), Expect = 3e-41
Identities = 105/272 (38%), Positives = 156/272 (56%), Gaps = 20/272 (7%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
+I KSGDD RQ+ A Q+I +I+ + N+ +++ ++ TSS TG++E I N+ S
Sbjct: 1180 LIFKSGDDCRQDMLALQIISMFESIFKQANLDIFLYPYKVMATSSGTGIIEVIPNSKSRD 1239
Query: 743 SIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICY 802
I K +I +LL++F +G + A NFASSLA YS++ Y
Sbjct: 1240 QIGKE---------------NINNLLEYFEYKFGFKESEGYLTAICNFASSLAGYSLVGY 1284
Query: 803 LLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESET 862
L IKDRHNGNIMID++G ++HIDFG+ML SPG++ E AP KLT E E++GG+ +
Sbjct: 1285 FLNIKDRHNGNIMIDDQGRMIHIDFGYMLEMSPGNLNIE-APLKLTKEIEELLGGTSGKG 1343
Query: 863 FKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDEE 922
F+ + EL F ALR+ + +V + + DS PC++ + LR RF ELSD+
Sbjct: 1344 FEIYQELMVKGFLALRRRSKDLVMMVDSF-VDSELPCYRRNAVENFILRFRF--ELSDKN 1400
Query: 923 CDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
FV + LI++S T +YD +Q +T I
Sbjct: 1401 ARRFVLS-LIAESSQKFRTWMYDQYQKITNNI 1431
>7290340 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 2113
Score = 166 bits (421), Expect = 1e-40
Identities = 107/269 (39%), Positives = 152/269 (55%), Gaps = 22/269 (8%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+ I K GDD+RQ+ A Q+I I+ + + +++ ++ T+ G++E + NA S
Sbjct: 1857 AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSR 1916
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
+ + + L ++F YGD + +F+ A+ NF S+AAYS+I
Sbjct: 1917 DQLGRQTDS---------------GLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIG 1961
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP-GSVGFEAAPFKLTYEYVEVMGGS-E 859
YLL+IKDRHNGNIMID +GH++HIDFGFM +SP G++GFE KLT E V +MGG +
Sbjct: 1962 YLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFE-PDMKLTDEMVMIMGGKMD 2020
Query: 860 SETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELS 919
S FK F ELC AF A+R Y D IVSL +M L PCF+ QT L+QRF +
Sbjct: 2021 SPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGL-PCFRG--QTINLLKQRFVATKN 2077
Query: 920 DEECDEFVENVLISKSLGSRYTRLYDHFQ 948
++E + V I S + TR YD Q
Sbjct: 2078 NKEAAAHMLAV-IRNSYQNFRTRTYDMIQ 2105
>Hs4505807 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 854
Score = 164 bits (415), Expect = 6e-40
Identities = 102/269 (37%), Positives = 152/269 (55%), Gaps = 22/269 (8%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+ I K GDD RQ+ A Q+I I+ + ++V ++ T+ G++E I + S
Sbjct: 598 AAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTS- 656
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
L + D + D+F+R YGD + F+ A+ NF S+AAYS++
Sbjct: 657 -------------RDQLGRQTDFG-MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLL 702
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP-GSVGFEAAPFKLTYEYVEVMGGS-E 859
+LL+IKDRHNGNIM+D +GH++HIDFGFM +SP G++G+E KLT E V +MGG E
Sbjct: 703 FLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWE-PDIKLTDEMVMIMGGKME 761
Query: 860 SETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELS 919
+ FK F+E+C + A+R Y D +VSL +M L PCF+ QT L+ RF ++
Sbjct: 762 ATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGL-PCFRG--QTIKLLKHRFSPNMT 818
Query: 920 DEECDEFVENVLISKSLGSRYTRLYDHFQ 948
+ E F+ V+ S L +R +R YD Q
Sbjct: 819 EREAANFIMKVIQSCFLSNR-SRTYDMIQ 846
>Hs17105400 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 2044
Score = 164 bits (415), Expect = 6e-40
Identities = 102/269 (37%), Positives = 152/269 (55%), Gaps = 22/269 (8%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+ I K GDD RQ+ A Q+I I+ + ++V ++ T+ G++E I + S
Sbjct: 1788 AAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTS- 1846
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
L + D + D+F+R YGD + F+ A+ NF S+AAYS++
Sbjct: 1847 -------------RDQLGRQTDFG-MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLL 1892
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP-GSVGFEAAPFKLTYEYVEVMGGS-E 859
+LL+IKDRHNGNIM+D +GH++HIDFGFM +SP G++G+E KLT E V +MGG E
Sbjct: 1893 FLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWE-PDIKLTDEMVMIMGGKME 1951
Query: 860 SETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELS 919
+ FK F+E+C + A+R Y D +VSL +M L PCF+ QT L+ RF ++
Sbjct: 1952 ATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGL-PCFRG--QTIKLLKHRFSPNMT 2008
Query: 920 DEECDEFVENVLISKSLGSRYTRLYDHFQ 948
+ E F+ V+ S L +R +R YD Q
Sbjct: 2009 EREAANFIMKVIQSCFLSNR-SRTYDMIQ 2036
>At1g49340 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1957
Score = 151 bits (381), Expect = 5e-36
Identities = 96/275 (34%), Positives = 147/275 (52%), Gaps = 22/275 (8%)
Query: 684 ISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHS 743
I K GDD RQ+ A Q+I + I+ + +++ +L T + G++E + N S
Sbjct: 1699 IFKVGDDCRQDVLALQVISLLRDIFQAAGLNLYLFPYGVLPTGAERGIIEVVPNTRS--- 1755
Query: 744 IKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYL 803
+ E D L + F + YG F A++NF S A Y++ L
Sbjct: 1756 -----------RSQMGETTD-GGLYEIFQQDYGPVGSTTFETARENFLISSAGYAVASLL 1803
Query: 804 LRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP-GSVGFEAAPFKLTYEYVEVM---GGSE 859
L+ KDRHNGN++ D+ G +VHIDFGF+L SP G++ FE+A FKL++E +++ G +
Sbjct: 1804 LQPKDRHNGNLLFDDVGRLVHIDFGFILETSPGGNMRFESAHFKLSHEMTQLLDPSGVMK 1863
Query: 860 SETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELS 919
S+T+ +FV LC + A R+ D I+S ++M + L PCF GD LR+RFH E+S
Sbjct: 1864 SKTWHQFVSLCVKGYLAARRQMDGIISTVQMMLESGL-PCFSRGDPIG-NLRKRFHPEMS 1921
Query: 920 DEECDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
+ E F+ +V + + T YD Q L QGI
Sbjct: 1922 EREAAHFMIHV-CTDAYNKWTTAGYDLIQYLQQGI 1955
>7291958 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 1572
Score = 142 bits (358), Expect = 2e-33
Identities = 71/147 (48%), Positives = 104/147 (70%), Gaps = 2/147 (1%)
Query: 809 RHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVE 868
RHNGNI+ ++GH++HIDFGF+LS SP ++GFE +PFKLT E+VEVMGG+ SE +++F +
Sbjct: 1426 RHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLTPEFVEVMGGTSSEHWREFNK 1485
Query: 869 LCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQ-LRQRFHLELSDEECDEFV 927
L + RK+ D I++ EIM+ ++ PCF+ G +VQ LR+RFH+ L+++E + V
Sbjct: 1486 LLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKV 1545
Query: 928 ENVLISKSLGSRYTRLYDHFQLLTQGI 954
E L+ SL S T+LYD +Q T GI
Sbjct: 1546 EQ-LVQDSLKSLSTKLYDGYQYYTNGI 1571
Score = 61.2 bits (147), Expect = 7e-09
Identities = 30/63 (47%), Positives = 39/63 (61%)
Query: 640 TGGLTTSNDKTSTSYLGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFACQ 699
T + + S + L E W+ K++ IR+SS +GHL NW L S I K GDDLRQE A Q
Sbjct: 1353 TKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQ 1412
Query: 700 LIQ 702
L+Q
Sbjct: 1413 LLQ 1415
Score = 52.0 bits (123), Expect = 4e-06
Identities = 27/85 (31%), Positives = 52/85 (60%), Gaps = 6/85 (7%)
Query: 365 QFAIALESISQRLAQVPPEA-RLSALRAELSILNRDLPAEVDIPELLPVNKKGKLHKLIK 423
+F AL ++ + L P +A + SALR L+++N++LPA V +P + H +++
Sbjct: 1122 EFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYSDIP-----HHVVR 1176
Query: 424 ISANEAQVLNSAEKVPYLLFIEFLK 448
I+ + VLNS +K PY++++E ++
Sbjct: 1177 ITEEKTAVLNSKDKTPYIIYVEVVE 1201
>At1g51040 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 525
Score = 138 bits (347), Expect = 5e-32
Identities = 95/275 (34%), Positives = 141/275 (50%), Gaps = 30/275 (10%)
Query: 684 ISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHS 743
I K GDD RQ+ A Q+I + I+ + +++ +L T + N S
Sbjct: 275 IFKVGDDCRQDVLALQVISLLGDIFQAVGLNLYLFPYGVLPT--------VVPNTRS--- 323
Query: 744 IKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYL 803
+ E D L + F + YG F A+ NF S A Y++ L
Sbjct: 324 -----------RSQMGETTD-GGLYEIFQQNYGLVGSTTFETARANFLISSAGYAVASLL 371
Query: 804 LRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP-GSVGFEAAPFKLTYEYVEVM---GGSE 859
L+ KDRHNGN++ D+ G +VHIDFGF+L SP G++ FE A FKL++E +++ G +
Sbjct: 372 LQPKDRHNGNLLFDDVGRLVHIDFGFILETSPGGNMRFENAHFKLSHEMTQLLDPSGVMK 431
Query: 860 SETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELS 919
S+T+ +FV LC + A R+Y D I+S ++M + L PCF GD LR+RFH E+S
Sbjct: 432 SKTWHQFVSLCVKGYLAARRYMDEIISTVQMMLESGL-PCFSRGDPIG-NLRKRFHPEMS 489
Query: 920 DEECDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
+ E F+ NV + + T YD Q L QG+
Sbjct: 490 EREAALFMINV-CTDAYNKWTTAGYDLIQYLQQGV 523
>Hs4505801 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 887
Score = 132 bits (331), Expect = 3e-30
Identities = 96/369 (26%), Positives = 174/369 (47%), Gaps = 38/369 (10%)
Query: 601 QIRAKIIASMQEMQDKFGYRDLEAIHGMAGERKLENDFKTGGLTTSNDKTSTS------- 653
++ ++A+ Q D+ + ++A+ +G RK +N+ + L N+K + S
Sbjct: 536 RVMRSLLAAQQTFVDRLVHL-MKAVQRESGNRKKKNE-RLQALLGDNEKMNLSDVELIPL 593
Query: 654 ----------YLGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFACQLIQA 703
+ E K + + F + VI K GDDLRQ+ Q+I
Sbjct: 594 PLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISL 653
Query: 704 MAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSLDEKGD 763
M + KEN+ + + +L TS+ G ++ I ++ V + LD +G
Sbjct: 654 MDKLLRKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEV-------------LDTEGS 699
Query: 764 IASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVV 823
I + ++ PNG D + S A Y +I Y+L + DRH N+++ G +
Sbjct: 700 IQNFFRKYAPSENGPNGIS-AEVMDTYVKSCAGYCVITYILGVGDRHLDNLVLTKTGKLF 758
Query: 824 HIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADH 883
HIDFG++L P + P KL E VE MGG++SE +++F + C AF LR+Y++
Sbjct: 759 HIDFGYILGRDPKPL---PPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNL 815
Query: 884 IVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECDEFVENVLISKSLGSRYTRL 943
I++L +M ++ D+T +++ +F L+LSDEE ++++ LI +S+ + + +
Sbjct: 816 ILNLFSLMVDPNIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQS-LIDESVHALFAAV 874
Query: 944 YDHFQLLTQ 952
+ Q
Sbjct: 875 VEQIHKFAQ 883
>Hs18589256 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 887
Score = 132 bits (331), Expect = 3e-30
Identities = 96/369 (26%), Positives = 174/369 (47%), Gaps = 38/369 (10%)
Query: 601 QIRAKIIASMQEMQDKFGYRDLEAIHGMAGERKLENDFKTGGLTTSNDKTSTS------- 653
++ ++A+ Q D+ + ++A+ +G RK +N+ + L N+K + S
Sbjct: 536 RVMRSLLAAQQTFVDRLVHL-MKAVQRESGNRKKKNE-RLQALLGDNEKMNLSDVELIPL 593
Query: 654 ----------YLGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDDLRQEAFACQLIQA 703
+ E K + + F + VI K GDDLRQ+ Q+I
Sbjct: 594 PLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISL 653
Query: 704 MAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHSIKKSLTTHMIEEGSLDEKGD 763
M + KEN+ + + +L TS+ G ++ I ++ V + LD +G
Sbjct: 654 MDKLLRKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEV-------------LDTEGS 699
Query: 764 IASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVV 823
I + ++ PNG D + S A Y +I Y+L + DRH N+++ G +
Sbjct: 700 IQNFFRKYAPSENGPNGIS-AEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLF 758
Query: 824 HIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADH 883
HIDFG++L P + P KL E VE MGG++SE +++F + C AF LR+Y++
Sbjct: 759 HIDFGYILGRDPKPL---PPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNL 815
Query: 884 IVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECDEFVENVLISKSLGSRYTRL 943
I++L +M ++ D+T +++ +F L+LSDEE ++++ LI +S+ + + +
Sbjct: 816 ILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQS-LIDESVHALFAAV 874
Query: 944 YDHFQLLTQ 952
+ Q
Sbjct: 875 VEQIHKFAQ 883
>Hs22068531 [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 523
Score = 130 bits (328), Expect = 7e-30
Identities = 76/194 (39%), Positives = 113/194 (58%), Gaps = 18/194 (9%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+ I K GDD RQ+ A Q+I I+ + ++V ++ T+ G++E I + S
Sbjct: 313 AAIFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTS- 371
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
L + D + D+F+R YGD + F+ A+ NF S+AAYS++
Sbjct: 372 -------------RDQLGRQTDFG-MYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLL 417
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP-GSVGFEAAPFKLTYEYVEVMGGS-E 859
+LL+IKDRHNGNIM+D +GH++HIDFGFM +SP G++G+E KLT E V +MGG E
Sbjct: 418 FLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWE-PDIKLTDEMVMIMGGKME 476
Query: 860 SETFKKFVELCKAA 873
+ FK F+E+C A
Sbjct: 477 ATPFKWFMEMCVQA 490
>At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 814
Score = 124 bits (311), Expect = 7e-28
Identities = 78/265 (29%), Positives = 134/265 (50%), Gaps = 19/265 (7%)
Query: 681 CSVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAIS 740
C +I K GDDLRQ+ Q++ M + EN+ + + +L T G++E I +
Sbjct: 559 CKLIFKKGDDLRQDQLVVQMVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPS--- 615
Query: 741 VHSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSII 800
S+ + L+ H I S L F P G D F S A YS+I
Sbjct: 616 -RSLAQILSEHR----------SITSYLQKFHPDEHAPFGITAT-CLDTFIKSCAGYSVI 663
Query: 801 CYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSES 860
Y+L I DRH N+++ ++G + H+DF F+L P P KL E VE MGG+ES
Sbjct: 664 TYILGIGDRHLDNLLLTDDGRLFHVDFAFILGRDPKPF---PPPMKLCKEMVEAMGGAES 720
Query: 861 ETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSD 920
+ + +F C A+ LRK ++ I++L +M ++ ++ ++L+++F L++ D
Sbjct: 721 QYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASDPEKGILKLQEKFRLDMDD 780
Query: 921 EECDEFVENVLISKSLGSRYTRLYD 945
E C F ++ LI++S+ + + ++ +
Sbjct: 781 EACIHFFQD-LINESVSALFPQMVE 804
>YLR240w [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 875
Score = 115 bits (287), Expect = 4e-25
Identities = 80/273 (29%), Positives = 124/273 (45%), Gaps = 31/273 (11%)
Query: 686 KSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHSIK 745
K GDDLRQ+ Q+I M + ENV + + IL T G +E I N +
Sbjct: 624 KVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKILATGPQEGAIEFIPNDTLASILS 683
Query: 746 KSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQ--DNFASSLAAYSIICYL 803
K +L + Y D N DNF S A Y +I Y+
Sbjct: 684 K-----------------YHGILGYLKLHYPDENATLGVQGWVLDNFVKSCAGYCVITYI 726
Query: 804 LRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPF----KLTYEYVEVMGGSE 859
L + DRH N+++ +GH H DFG++L P PF KL + +E GG+E
Sbjct: 727 LGVGDRHLDNLLVTPDGHFFHADFGYILGQDP-------KPFPPLMKLPPQIIEAFGGAE 779
Query: 860 SETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELS 919
S + KF C A+ LR+ A I++L E+M+ ++ + +++R+RF+L +S
Sbjct: 780 SSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMS 839
Query: 920 DEECDEFVENVLISKSLGSRYTRLYDHFQLLTQ 952
+E+ +N LI+ S+ + + DH L Q
Sbjct: 840 EEDATVHFQN-LINDSVNALLPIVIDHLHNLAQ 871
>HsM4505803 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1101
Score = 114 bits (284), Expect = 9e-25
Identities = 69/214 (32%), Positives = 118/214 (54%), Gaps = 14/214 (6%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
+I K GDDLRQ+ Q+++ M +IW E++ + + + T G++E + +A ++
Sbjct: 829 IIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIA 888
Query: 743 SIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICY 802
I++S + G+ ++ +L+H+ + P KF+ A + F S A Y + +
Sbjct: 889 KIQQSTVGNT---GAFKDE-----VLNHWLKEKS-PTEEKFQAAVERFVYSCAGYCVATF 939
Query: 803 LLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF--EAAPFKLTYEYVEVMGGSES 860
+L I DRHN NIMI G++ HIDFG +L N +G E PF LT +++ VMG S
Sbjct: 940 VLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGK 999
Query: 861 ET---FKKFVELCKAAFKALRKYADHIVSLCEIM 891
+T F+KF ++C A+ ALR + + ++ L +M
Sbjct: 1000 KTSPHFQKFQDICVKAYLALRHHTNLLIILFSMM 1033
>Hs21237725 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1102
Score = 114 bits (284), Expect = 9e-25
Identities = 69/214 (32%), Positives = 118/214 (54%), Gaps = 14/214 (6%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
+I K GDDLRQ+ Q+++ M +IW E++ + + + T G++E + +A ++
Sbjct: 830 IIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIA 889
Query: 743 SIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICY 802
I++S + G+ ++ +L+H+ + P KF+ A + F S A Y + +
Sbjct: 890 KIQQSTVGNT---GAFKDE-----VLNHWLKEKS-PTEEKFQAAVERFVYSCAGYCVATF 940
Query: 803 LLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF--EAAPFKLTYEYVEVMGGSES 860
+L I DRHN NIMI G++ HIDFG +L N +G E PF LT +++ VMG S
Sbjct: 941 VLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGK 1000
Query: 861 ET---FKKFVELCKAAFKALRKYADHIVSLCEIM 891
+T F+KF ++C A+ ALR + + ++ L +M
Sbjct: 1001 KTSPHFQKFQDICVKAYLALRHHTNLLIILFSMM 1034
>CE24760 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 650
Score = 114 bits (284), Expect = 9e-25
Identities = 80/273 (29%), Positives = 133/273 (48%), Gaps = 15/273 (5%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+VI K+GDDLRQ+ Q+++ + I K + + + +L T G V+ I
Sbjct: 392 TVIFKTGDDLRQDQLIQQMVRLIDIILKKGQLDLKLTPYLVLSTGVGQGFVQCI------ 445
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
KS I+E K D R P G + + DN+ SLA YS+I
Sbjct: 446 ----KSKPLRAIQEQYKAHKMDCIREAMKELRPGDGPFGIE-PNVIDNYVRSLAGYSVIM 500
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESE 861
Y+L + DRH N+++ G + H+DFGF+L P + P KLT E V+VMGG +S+
Sbjct: 501 YILGLGDRHLDNLLLCENGKLFHVDFGFILGRDPKPM---PPPMKLTSEMVQVMGGVKSK 557
Query: 862 TFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDE 921
F +FV+ +A++ LR++++ +++L +M + D+ ++ QR L+LSDE
Sbjct: 558 QFLEFVQHVDSAYRILRRHSNVLLNLFSLMLDAGIPDIAAEPDKAIFKIEQRLRLDLSDE 617
Query: 922 ECDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
+ + I SL ++ + D Q +
Sbjct: 618 AATKHI-FTQIESSLNAKMAMISDIIHAYKQNL 649
>CE24759 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 901
Score = 114 bits (284), Expect = 9e-25
Identities = 80/273 (29%), Positives = 133/273 (48%), Gaps = 15/273 (5%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+VI K+GDDLRQ+ Q+++ + I K + + + +L T G V+ I
Sbjct: 643 TVIFKTGDDLRQDQLIQQMVRLIDIILKKGQLDLKLTPYLVLSTGVGQGFVQCI------ 696
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
KS I+E K D R P G + + DN+ SLA YS+I
Sbjct: 697 ----KSKPLRAIQEQYKAHKMDCIREAMKELRPGDGPFGIE-PNVIDNYVRSLAGYSVIM 751
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESE 861
Y+L + DRH N+++ G + H+DFGF+L P + P KLT E V+VMGG +S+
Sbjct: 752 YILGLGDRHLDNLLLCENGKLFHVDFGFILGRDPKPM---PPPMKLTSEMVQVMGGVKSK 808
Query: 862 TFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDE 921
F +FV+ +A++ LR++++ +++L +M + D+ ++ QR L+LSDE
Sbjct: 809 QFLEFVQHVDSAYRILRRHSNVLLNLFSLMLDAGIPDIAAEPDKAIFKIEQRLRLDLSDE 868
Query: 922 ECDEFVENVLISKSLGSRYTRLYDHFQLLTQGI 954
+ + I SL ++ + D Q +
Sbjct: 869 AATKHI-FTQIESSLNAKMAMISDIIHAYKQNL 900
>SPAC458.05 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 801
Score = 113 bits (282), Expect = 2e-24
Identities = 84/278 (30%), Positives = 140/278 (50%), Gaps = 31/278 (11%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
+I K+GDDLRQ+ Q++ M + KE + + +K IL T G V+ + +
Sbjct: 543 IIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPS----- 597
Query: 743 SIKKSLTTHMIE-EGSLDEKGDIASLLDHF------SRVYG-DPNGFKFRHAQDNFASSL 794
K+L T + E GS+ +A L ++ S YG DP A DN+ S
Sbjct: 598 ---KTLATILAEYHGSV-----LAYLRENNPDDGLNSANYGIDPV------AMDNYVRSC 643
Query: 795 AAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEV 854
A Y +I YLL + DRH N++I +GH H DFG++L P + KL+ E VE
Sbjct: 644 AGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILGRDP---KLFSPAMKLSKEMVEG 700
Query: 855 MGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRF 914
MGG S +++F C F ALRK ++ I++L +M ++ ++ ++++RF
Sbjct: 701 MGGYNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMVDANIPDIKFDKEKVVYKVKERF 760
Query: 915 HLELSDEECDEFVENVLISKSLGSRYTRLYDHFQLLTQ 952
L++S+ + ++ E LI+ S+ + + ++ D L Q
Sbjct: 761 CLQMSESDAIKYFEQ-LINDSVSALFPQIIDRMHNLAQ 797
>7300643 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1088
Score = 112 bits (280), Expect = 3e-24
Identities = 82/301 (27%), Positives = 140/301 (46%), Gaps = 24/301 (7%)
Query: 631 ERKLENDFKTGGLTTSNDKTSTSYLGEDWNAKKEKIRKSSEFGHLPNWDLCSVISKSGDD 690
+ L F+ G+T K S + W + +S+ +I K+GDD
Sbjct: 775 QNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNASDV---------HIIFKNGDD 825
Query: 691 LRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVHSIKKSLTT 750
LRQ+ Q+++ M +W ++ + + N + G++E + +A ++ +I+K
Sbjct: 826 LRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKE--K 883
Query: 751 HMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRH 810
M S +KG + S L ++ K A + F S A Y + Y+L + DRH
Sbjct: 884 GMFSATSPFKKGSLLSWLKEHNKPAD-----KLNKAINEFTLSCAGYCVATYVLGVADRH 938
Query: 811 NGNIMIDNEGHVVHIDFGFMLSNSPGSVGF--EAAPFKLTYEYVEVM----GGSESETFK 864
+ NIM+ G + HIDFG +L + +G E PF LT+++V V+ ES+ F
Sbjct: 939 SDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFC 998
Query: 865 KFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDEECD 924
F ELC+ AF LRK+ I+SL +M L + ++ LR+ L+ ++E+
Sbjct: 999 HFQELCERAFLVLRKHGCLILSLFSMMISTGLPEL--SSEKDLDYLRETLVLDYTEEKAR 1056
Query: 925 E 925
E
Sbjct: 1057 E 1057
>Hs4505799 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1686
Score = 112 bits (279), Expect = 4e-24
Identities = 87/269 (32%), Positives = 133/269 (49%), Gaps = 25/269 (9%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+V+ K G+DLRQ+ A Q+I+ M IW KE + + + L T G+VE + + ++
Sbjct: 1134 NVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTL 1193
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
I+ GS +K L + R Y +P+ ++ A +NF S A +
Sbjct: 1194 RKIQVEYGV----TGSFKDKP-----LAEWLRKY-NPSEEEYEKASENFIYSCAGCCVAT 1243
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP--GSVGFEAAPFKLTYEYVEVMGGSE 859
Y+L I DRHN NIM+ + GH+ HIDFG L ++ GS + APF LT + V+ G E
Sbjct: 1244 YVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGE 1303
Query: 860 SET--FKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQ----LRQR 913
T F+ FV+LC A+ +RK + ++L +M L + TS+Q +R
Sbjct: 1304 KPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLP------ELTSIQDLKYVRDA 1357
Query: 914 FHLELSDEECDEFVENVLISKSLGSRYTR 942
+ +D E F LI SLGS T+
Sbjct: 1358 LQPQTTDAEATIFFTR-LIESSLGSIATK 1385
>Hs4758924 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1448
Score = 109 bits (272), Expect = 2e-23
Identities = 71/214 (33%), Positives = 110/214 (51%), Gaps = 14/214 (6%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
S+I K+GDDLRQ+ QLIQ M IW +E + + + L T LV+ + +A+++
Sbjct: 917 SIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQRLVQMVPDAVTL 976
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
I + H G L E I + + D + A NF S A + ++
Sbjct: 977 AKIHR----HSGLIGPLKEN-TIKKWFSQHNHLKAD-----YEKALRNFFYSCAGWCVVT 1026
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP--GSVGFEAAPFKLT--YEYVEVMGG 857
++L + DRHN NIM+ GH+ HIDFG L ++ G + + APF T EY GG
Sbjct: 1027 FILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGG 1086
Query: 858 SESETFKKFVELCKAAFKALRKYADHIVSLCEIM 891
+ F+ FVELC A+ +RK++ +++L E+M
Sbjct: 1087 KNPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMM 1120
>CE05832 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1607
Score = 108 bits (269), Expect = 5e-23
Identities = 79/267 (29%), Positives = 127/267 (46%), Gaps = 20/267 (7%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
S+I K DD+RQ+AF +++ M IW + + + I+ G+ E + N ++
Sbjct: 1055 SIIHKRDDDMRQDAFVMKMLNEMDRIWKSNGLDLRMITFRIMPVGYRRGMGELVLNCATL 1114
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
I+K + + K L+ H S + F ++ AQ+NF S A + I+
Sbjct: 1115 MEIQKEEGLRGVLNDEILRKW----LMKHNS------DEFAYKEAQENFIRSCAGWCIVT 1164
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF--EAAPFKLTYEYVEVM--GG 857
Y+L I DRHN NI+ GHV HIDFG + + + GF + PF T E V+ G
Sbjct: 1165 YVLGIGDRHNDNILFTKNGHVFHIDFGKYMGDWQMAAGFRRDRVPFVFTTEMFHVINNGR 1224
Query: 858 SESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLE 917
+ ++ +KF++ C AF LR+ + + +L IM + P V+ L+
Sbjct: 1225 APTQYNQKFIDYCCKAFNHLRRNKNTLTNLLRIMACSDI-PGINMDSLAFVE--NNLMLD 1281
Query: 918 LSDEECD-EFVENVLISKSLGSRYTRL 943
LSD + +F +I SLGS + RL
Sbjct: 1282 LSDTDATVQF--TAMIQNSLGSAFVRL 1306
>7291607 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 1157
Score = 106 bits (264), Expect = 2e-22
Identities = 68/250 (27%), Positives = 119/250 (47%), Gaps = 18/250 (7%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISV 741
+ I K GDDLRQ+ Q+I M + +EN+ + + +L TSS G ++ + +
Sbjct: 694 AAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVA 753
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIIC 801
+ + +G+I + P G D + S A Y +I
Sbjct: 754 EVLAR--------------EGNIHNFFRKHHPCDNGPYGIS-AEVMDTYIKSCAGYCVIT 798
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESE 861
YLL + DRH N+++ G + HIDFG++L P + P KL+ E VE MGG SE
Sbjct: 799 YLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM---PPPMKLSKEMVEAMGGISSE 855
Query: 862 TFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRFHLELSDE 921
+F + C A+ LR++A+ +++L +M ++ D+ ++ + L L+DE
Sbjct: 856 HHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENLQLGLTDE 915
Query: 922 ECDEFVENVL 931
E + ++++L
Sbjct: 916 EAVQHLQSLL 925
>Hs15451926 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1634
Score = 105 bits (261), Expect = 4e-22
Identities = 70/213 (32%), Positives = 108/213 (49%), Gaps = 14/213 (6%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
VI K GDDLRQ+ Q+I+ M+ IW +E + + + T G+VE I NA
Sbjct: 1080 VIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNA---E 1136
Query: 743 SIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICY 802
+++K H + GS ++ L H +P ++ A +NF S A + Y
Sbjct: 1137 TLRKIQVEHGVT-GSFKDRPLADWLQKH------NPGEDEYEKAVENFIYSCAGCCVATY 1189
Query: 803 LLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP--GSVGFEAAPFKLTYEYVEVMGGSE- 859
+L I DRHN NIM+ GH+ HIDFG L ++ G++ + APF T + V+ G +
Sbjct: 1190 VLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDK 1249
Query: 860 -SETFKKFVELCKAAFKALRKYADHIVSLCEIM 891
S F FV+LC A+ +RK+ ++L +M
Sbjct: 1250 PSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLM 1282
>Hs5453894 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1070
Score = 104 bits (260), Expect = 6e-22
Identities = 62/218 (28%), Positives = 111/218 (50%), Gaps = 13/218 (5%)
Query: 679 DLCSVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNA 738
D VI K+GDDLRQ+ Q+++ M +W + + + + L T +GL+E ++ +
Sbjct: 798 DSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTS 857
Query: 739 ISVHSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYS 798
++ I+ L + + + K + + L ++ +G A + F S A Y
Sbjct: 858 ETIADIQ--LNSSNVAAAAAFNKDALLNWLKEYN------SGDDLDRAIEEFTLSCAGYC 909
Query: 799 IICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF--EAAPFKLTYEYVEVMG 856
+ Y+L I DRH+ NIM+ G + HIDFG +L N G E PF LTY+++ V+
Sbjct: 910 VASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQ 969
Query: 857 GSE---SETFKKFVELCKAAFKALRKYADHIVSLCEIM 891
+ +E F +F + C+ A+ LR++ + ++L +M
Sbjct: 970 QGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALM 1007
>7294673 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1876
Score = 104 bits (260), Expect = 6e-22
Identities = 70/211 (33%), Positives = 108/211 (51%), Gaps = 14/211 (6%)
Query: 676 PNWDLCSVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETI 735
P+ + I K GDDL+Q+ QLI+ M +W E + + + N + T +G++E +
Sbjct: 1317 PDAESLPAIFKCGDDLQQDQLTIQLIRIMNKMWLAERLDLKMVTFNCVPTGYKSGMIELV 1376
Query: 736 TNAISVHSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLA 795
+ A ++ I+ GS ++ IA L +P+ +++ A NF S A
Sbjct: 1377 SEAETLRKIQVECGL----TGSFKDR-PIAEWLGK-----QNPSPLEYQSAVRNFTLSCA 1426
Query: 796 AYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSP--GSVGFEAAPFKLTYEYVE 853
YS+ Y+L I DRHN NIM+ GH+ HIDFG L ++ G+ + PF LT +
Sbjct: 1427 GYSVATYVLGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAY 1486
Query: 854 VMGGSE--SETFKKFVELCKAAFKALRKYAD 882
V+ G + S F FV+LC AF +RK AD
Sbjct: 1487 VINGGDKPSTDFHYFVDLCCRAFNIVRKNAD 1517
>Hs5453892 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1068
Score = 103 bits (256), Expect = 2e-21
Identities = 73/252 (28%), Positives = 126/252 (49%), Gaps = 20/252 (7%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
+I K+GDDLRQ+ Q+I+ M IW + + + + L GL+E + N+ ++
Sbjct: 799 IIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIM 858
Query: 743 SIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPN-GFKFRHAQDNFASSLAAYSIIC 801
I+ +G L KG + + D N G + A D F S A Y +
Sbjct: 859 QIQC--------KGGL--KGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVAT 908
Query: 802 YLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF--EAAPFKLTYEYVEVMGGSE 859
++L I DRHN NIM+ ++G + HIDFG L + G+ E PF LT +++ V+
Sbjct: 909 FILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGA 968
Query: 860 SE-----TFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQRF 914
E F++F E+C A+ A+R++A+ ++L +M + P Q+ D + +R+
Sbjct: 969 QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGM-PELQSFDDIA-YIRKTL 1026
Query: 915 HLELSDEECDEF 926
L+ +++E E+
Sbjct: 1027 ALDKTEQEALEY 1038
>Hs19923289 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1044
Score = 102 bits (253), Expect = 4e-21
Identities = 68/219 (31%), Positives = 110/219 (50%), Gaps = 13/219 (5%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
+I K+GDDLRQ+ Q+IQ M +W +E + + + L T TGL+E + + ++
Sbjct: 776 IIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIA 835
Query: 743 SIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICY 802
+I+ + ++M + ++ +LL+ G A + F S A Y + Y
Sbjct: 836 NIQLN-KSNMAATAAFNKD----ALLNWLK---SKNPGEALDRAIEEFTLSCAGYCVATY 887
Query: 803 LLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF--EAAPFKLTYEYVEVM---GG 857
+L I DRH+ NIMI G + HIDFG L N G E PF LTY++V V+
Sbjct: 888 VLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKT 947
Query: 858 SESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSL 896
+ SE F++F C+ A+ LR++ + L +M+ L
Sbjct: 948 NNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGL 986
>CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1146
Score = 94.0 bits (232), Expect = 1e-18
Identities = 70/250 (28%), Positives = 110/250 (44%), Gaps = 41/250 (16%)
Query: 674 HLPNWDLCSVISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVE 733
HLP C++I K+GDDLRQ+ Q+++ M IW N+ + +L G++E
Sbjct: 845 HLP---FCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIE 901
Query: 734 TITNA--------------ISVHSIKKSLTTHMIEE--GSLDEK---------GDIASLL 768
+ N +V SI S I + G DEK I +
Sbjct: 902 VVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKI 961
Query: 769 DHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFG 828
D+ + K+ + D F S YS+ Y++ IKDRH+ N+M+ +G HIDFG
Sbjct: 962 DNTQAMK------KYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFG 1015
Query: 829 FMLSNSPGSVGF--EAAPFKLTYEYVEVMGGSE-----SETFKKFVELCKAAFKALRKYA 881
+L + +G + PF LT ++ V+ + S +KF LC A++ +
Sbjct: 1016 HILGHGKTKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNR 1075
Query: 882 DHIVSLCEIM 891
D VSL +M
Sbjct: 1076 DLFVSLFTLM 1085
>YBL088c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2787
Score = 67.8 bits (164), Expect = 8e-11
Identities = 61/274 (22%), Positives = 118/274 (42%), Gaps = 29/274 (10%)
Query: 682 SVISKSGDDLRQEAFACQLIQAMAAIWSKE----NVGVWVKKMNILITSSHTGLVETITN 737
+++ S DDLRQ+A Q+ Q + + + N+ + ++ ++ G++E + N
Sbjct: 2462 ALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRTYKVVPLGPKAGIIEFVAN 2521
Query: 738 AISVHSIKKSLTTH-------------MIEEGSLDEK--------GDIASLLDHFSRVYG 776
+ S+H I L T+ ++ S +E+ +I L +F
Sbjct: 2522 STSLHQILSKLHTNDKITFDQARKGMKAVQTKSNEERLKAYLKITNEIKPQLRNFF-FDS 2580
Query: 777 DPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMID-NEGHVVHIDFGFMLSNSP 835
P+ + A+ + +AA SI+ Y+L + DRH NI++D + G +HID G
Sbjct: 2581 FPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGK 2640
Query: 836 GSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDS 895
E PF+LT + V+ G + + F C+ + LRK ++ + I++ D
Sbjct: 2641 LLPIPELVPFRLTRDIVDGFGVTGVDGL--FRRSCERVYAVLRKDYVKVMCVLNILKWDP 2698
Query: 896 LQPCFQAGDQTSVQLRQRFHLELSDEECDEFVEN 929
L + + L + H + + +F+ N
Sbjct: 2699 LYSWVMSPVKKYEHLFEEEHEITNFDNVSKFISN 2732
>SPCC23B6.03c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2812
Score = 65.9 bits (159), Expect = 3e-10
Identities = 63/247 (25%), Positives = 112/247 (44%), Gaps = 40/247 (16%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIW------SKENVGVWVKKMNILITSSHTGLVETIT 736
++ DDLRQ+A Q+ + + S+ N+ + K ++ + TG++E +
Sbjct: 2478 LVKGGNDDLRQDAVMEQVFEQVNGFLRSYRKTSQRNLSMRTYK--VIPLALKTGVIEWVQ 2535
Query: 737 NAISV-----------HSIKKSLTT--HMIEEGSLDEKGDIASLLD------------HF 771
+ I + H + SL+T +I E +++ + D F
Sbjct: 2536 DTIPLGEYLDSAHKVYHPKEWSLSTCRKLIAEKQMEDLETRLKVYDLVCRHYRPVFRHFF 2595
Query: 772 SRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMID-NEGHVVHIDFGFM 830
Y DP ++ Q N+A S A S++ ++L + DRH NI+ID G V+HID G
Sbjct: 2596 LESYADP--VQWFTTQTNYARSTAVASVLGHVLGLGDRHGQNILIDKTSGEVIHIDLGIA 2653
Query: 831 LSNSPGSVGFEAAPFKLTYEYVEVMGGSESE-TFKKFVELCKAAFKALRKYADHIVSLCE 889
E PF+LT + V+ MG + E F++ +E + LR+ D ++S+ E
Sbjct: 2654 FEQGKKLPVPECVPFRLTRDVVDGMGITGVEGVFRRCMEF---TLETLRREEDSLLSVLE 2710
Query: 890 IMQKDSL 896
+++ D L
Sbjct: 2711 VLRYDPL 2717
>7299977 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2429
Score = 62.4 bits (150), Expect = 3e-09
Identities = 35/108 (32%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 790 FASSLAAYSIICYLLRIKDRHNGNIMIDNE-GHVVHIDFGFMLSNSPGSVGFEAAPFKLT 848
+ +S+A S++ Y+L + DRH NI++D + V+HIDFG E PF+LT
Sbjct: 2248 YTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKIQTTPETVPFRLT 2307
Query: 849 YEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSL 896
++V MG T F + C+A LR+Y ++ E++ D L
Sbjct: 2308 RDFVAPMG--ICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPL 2353
>ECU10g0590 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 458
Score = 60.8 bits (146), Expect = 9e-09
Identities = 57/247 (23%), Positives = 103/247 (41%), Gaps = 32/247 (12%)
Query: 683 VISKSGDDLRQEAFACQLIQAMAAIWSKENVGVWVKKMNILITSSHTGLVETITNAISVH 742
+I K GDDL ++ F + I+ M+ + +GV + ++ S G+VE + + I
Sbjct: 216 IIYKKGDDLTRDLFVLETIRYMSRL-----MGVDLVTYKVIPLSRKEGIVEVV-DGIDFT 269
Query: 743 SIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFKFRHAQDNFASSLAAYSIICY 802
I+ M E D + F+ R F S+L YS+ CY
Sbjct: 270 RIRSRKDLEMYIEEDRDPRHQ---------------ESFEKRKV---FVSTLCGYSVACY 311
Query: 803 LLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGFEAAPFKLTYEYVEVMGGSESET 862
++ I DR+ GN+M+ +G HIDF + P + + +Y+ ++
Sbjct: 312 VMGIGDRNPGNMMVTRDGKFFHIDFSHVFGRDPKPISSRITIARPIRDYLV----NDELI 367
Query: 863 FKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSVQLRQ-RFHLELSDE 921
++ F+ AF +R+ I L I+ ++ + FQ + Q R +E+S++
Sbjct: 368 YQDFLARSGEAFLQIRRSCRKIFVLWCILAQNRI---FQFDLNEIIPFAQARLRMEMSEQ 424
Query: 922 ECDEFVE 928
E E
Sbjct: 425 RALELFE 431
>SPBC30D10.10c [L] KOG0891 DNA-dependent protein kinase
Length = 2335
Score = 57.8 bits (138), Expect = 8e-08
Identities = 54/244 (22%), Positives = 107/244 (43%), Gaps = 33/244 (13%)
Query: 684 ISKSGDDLRQEAFACQLIQAMAAIWSKENVG----VWVKKMNILITSSHTGLVETITNAI 739
+ K +DLRQ+ QL + + ++ + +++ ++ S ++GL+ + ++
Sbjct: 1984 VLKGHEDLRQDERVMQLFGLCNTLLTTDSETFKRRLNIERYTVIPLSPNSGLLGWVPHSD 2043
Query: 740 SVHSI------KKSLTTHMIEEGSLDEKGDIASL-----LDHFSRVYGDPNGFKFRHA-- 786
++H + K+++ ++ L D SL L+ F V + +G+ H
Sbjct: 2044 TLHFLIKEFRSKRNILLNLEHRMMLQMAPDCDSLTLLQKLEVFEYVMANTDGYDLYHVLW 2103
Query: 787 ------------QDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSN 833
+ ++ SLA S++ Y+L + DRH N+M+D G ++HIDFG
Sbjct: 2104 LKSRSSEAWLDRRTSYTQSLAVMSMVGYILGLGDRHPSNLMMDRYSGKIIHIDFGDCFEV 2163
Query: 834 SPGSVGF-EAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQ 892
+ F E PF+LT + M S + K C+ + LR + ++++ E
Sbjct: 2164 AMHREKFPEKIPFRLTRMLINAMEVSGIQGTYKIT--CELVMRVLRSNTESLMAVLEAFV 2221
Query: 893 KDSL 896
D L
Sbjct: 2222 YDPL 2225
>SPBC216.05 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2386
Score = 57.8 bits (138), Expect = 8e-08
Identities = 39/128 (30%), Positives = 63/128 (48%), Gaps = 7/128 (5%)
Query: 771 FSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGF 829
F + +PN + ++ N+ +LA SI+ Y+L + DRH NI+ D G +H+DF
Sbjct: 2195 FVESFPEPNNWVT--SRQNYCRTLAVMSIVGYVLGLGDRHGENILFDEFTGEAIHVDFNC 2252
Query: 830 MLSNSPGSVGFEAAPFKLTYEYVEVMGGSESE-TFKKFVELCKAAFKALRKYADHIVSLC 888
+ E PF+LT+ V+ MG + E F+K E+ + LR D ++S+
Sbjct: 2253 LFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGGFRKASEI---TMRLLRSNQDTLMSVL 2309
Query: 889 EIMQKDSL 896
E D L
Sbjct: 2310 ESFLHDPL 2317
>7297995 [L] KOG0891 DNA-dependent protein kinase
Length = 2470
Score = 55.5 bits (132), Expect = 4e-07
Identities = 55/243 (22%), Positives = 109/243 (44%), Gaps = 35/243 (14%)
Query: 686 KSGDDLRQEAFACQLIQAMAAIWSKE----NVGVWVKKMNILITSSHTGLVETITNAISV 741
K +DLRQ+ QL + + + + +++ ++ S+++GL+ + + ++
Sbjct: 2108 KGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTL 2167
Query: 742 HSI------KKSLTTHMIEEGSLDEKGDIASL--------LDH-FSRVYGD--------- 777
H++ KK + + L+ D L +H + GD
Sbjct: 2168 HTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLK 2227
Query: 778 -PNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSNSP 835
P+ + ++N+ SLA S++ Y+L + DRH N+M+D G ++HIDFG +
Sbjct: 2228 SPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAM 2287
Query: 836 GSVGF-EAAPFKLTYEYVEVMGGSESE-TFKKFVELCKAAFKALRKYADHIVSLCEIMQK 893
F E PF+LT ++ M + E T+++ C++ LR+ D ++++ E
Sbjct: 2288 TREKFPEKIPFRLTRMLIKAMEVTGIEGTYRR---TCESVMLVLRRNKDSLMAVLEAFVY 2344
Query: 894 DSL 896
D L
Sbjct: 2345 DPL 2347
>Hs4502325 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2644
Score = 55.1 bits (131), Expect = 5e-07
Identities = 35/127 (27%), Positives = 60/127 (46%), Gaps = 5/127 (3%)
Query: 771 FSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGF 829
F R + DP + ++ + S A S++ Y+L + DRH NI+ D+ G VH+DF
Sbjct: 2440 FLRTFPDPTSWY--SSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNC 2497
Query: 830 MLSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCE 889
+ + E PF+LT+ V MG +E F C+ + +R + ++S+ +
Sbjct: 2498 LFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGL--FRRACEVTMRLMRDQREPLMSVLK 2555
Query: 890 IMQKDSL 896
D L
Sbjct: 2556 TFLHDPL 2562
>Hs22041606 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 1212
Score = 55.1 bits (131), Expect = 5e-07
Identities = 35/127 (27%), Positives = 60/127 (46%), Gaps = 5/127 (3%)
Query: 771 FSRVYGDPNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGF 829
F R + DP + ++ + S A S++ Y+L + DRH NI+ D+ G VH+DF
Sbjct: 1008 FLRTFPDPTSWY--SSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNC 1065
Query: 830 MLSNSPGSVGFEAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCE 889
+ + E PF+LT+ V MG +E F C+ + +R + ++S+ +
Sbjct: 1066 LFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGL--FRRACEVTMRLMRDQREPLMSVLK 1123
Query: 890 IMQKDSL 896
D L
Sbjct: 1124 TFLHDPL 1130
>YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2368
Score = 53.1 bits (126), Expect = 2e-06
Identities = 56/232 (24%), Positives = 107/232 (45%), Gaps = 30/232 (12%)
Query: 689 DDLRQEAFACQLIQAMAAIWSKENVG----VWVKKMNILITSSHTGLVETITNAISVHSI 744
+D+RQ+ Q M + SK+ + + ++L G++E + N +++ SI
Sbjct: 2082 EDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSI 2141
Query: 745 ----------KKSLTT------HMIEEGSLD---EKGDIASLLDHFSRVYGDPNGFKFRH 785
K SL + H +G L+ E+ D + + + P+ + +
Sbjct: 2142 LSTKYESLKIKYSLKSLHDRWQHTAVDGKLEFYMEQVDKFPPILYQWFLENFPDPINWFN 2201
Query: 786 AQDNFASSLAAYSIICYLLRIKDRHNGNIMID-NEGHVVHIDFGFMLSNSPGSVGFEAAP 844
A++ +A S A +++ ++L + DRH NI++D G V+H+DF + E P
Sbjct: 2202 ARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVP 2261
Query: 845 FKLTYEYVEVMG--GSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKD 894
F+LT ++ +G G+E TFKK E+ A +RK ++++ E + D
Sbjct: 2262 FRLTPNLLDALGIIGTEG-TFKKSSEVTLA---LMRKNEVALMNVIETIMYD 2309
>CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2514
Score = 52.8 bits (125), Expect = 3e-06
Identities = 31/91 (34%), Positives = 48/91 (52%), Gaps = 4/91 (4%)
Query: 790 FASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF-EAAPFKLT 848
FA S A S+I Y+ + DRH N+M+ G +H+DF M+ N ++G E PF+LT
Sbjct: 2336 FAKSTAVMSVIGYIFGLGDRHTKNLMVHTTGKCIHVDFD-MIFNKGETLGTPELVPFRLT 2394
Query: 849 YEYVEVMGGSESETFKKFVELCKAAFKALRK 879
+ MG E +F +C+ A + R+
Sbjct: 2395 QNMINGMG--EVALDGEFRTVCEQALRVFRE 2423
>CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2531
Score = 52.8 bits (125), Expect = 3e-06
Identities = 31/91 (34%), Positives = 48/91 (52%), Gaps = 4/91 (4%)
Query: 790 FASSLAAYSIICYLLRIKDRHNGNIMIDNEGHVVHIDFGFMLSNSPGSVGF-EAAPFKLT 848
FA S A S+I Y+ + DRH N+M+ G +H+DF M+ N ++G E PF+LT
Sbjct: 2353 FAKSTAVMSVIGYIFGLGDRHTKNLMVHTTGKCIHVDFD-MIFNKGETLGTPELVPFRLT 2411
Query: 849 YEYVEVMGGSESETFKKFVELCKAAFKALRK 879
+ MG E +F +C+ A + R+
Sbjct: 2412 QNMINGMG--EVALDGEFRTVCEQALRVFRE 2440
>SPBC216.07c [L] KOG0891 DNA-dependent protein kinase
Length = 1973
Score = 52.4 bits (124), Expect = 3e-06
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 789 NFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSNSPGSVGF-EAAPFK 846
N++ +LA S++ Y+L + DRH N+M+D G+++HIDFG + F E PF+
Sbjct: 1757 NYSRTLAVMSMVGYILGLGDRHPSNLMLDRYTGNIIHIDFGDCFEVAMHREKFPEKIPFR 1816
Query: 847 LTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSL 896
LT V M S E F C+ + LR + ++++ E D L
Sbjct: 1817 LTRMLVNAMEVSGIE--GTFRITCEHVMRVLRTNKESVMAVLEAFVYDPL 1864
>At5g40820 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2810
Score = 52.4 bits (124), Expect = 3e-06
Identities = 34/148 (22%), Positives = 72/148 (47%), Gaps = 4/148 (2%)
Query: 790 FASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSNSPGSVGFEAAPFKLT 848
+A + A +S++ +++ + DRH NI+ D+ G VH+DF + E PF+LT
Sbjct: 2529 YAHTTAVWSMVGHIVGLGDRHGENILFDSTSGDCVHVDFSCLFDKGLQLEKPELVPFRLT 2588
Query: 849 YEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSLQPCFQAGDQTSV 908
++ +G + E F+ +C+ LR + + ++S+ E D L ++ + V
Sbjct: 2589 QNMIDGLGITGYEGI--FMRVCEITLTVLRTHRETLMSILETFIHDPLVEWTKSHKSSGV 2646
Query: 909 QLRQRFHLELSDEECDEFVENVLISKSL 936
++ Q H + + + ++ V++ L
Sbjct: 2647 EV-QNPHAQRAISSIEARLQGVVVGVPL 2673
>Hs4826730 [L] KOG0891 DNA-dependent protein kinase
Length = 2549
Score = 51.6 bits (122), Expect = 6e-06
Identities = 53/242 (21%), Positives = 104/242 (42%), Gaps = 33/242 (13%)
Query: 686 KSGDDLRQEAFACQLIQAMAAIWSKENVGVW----VKKMNILITSSHTGLVETITNAISV 741
K +DLRQ+ QL + + + + + +++ ++ S+++GL+ + + ++
Sbjct: 2187 KGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTL 2246
Query: 742 HSI------KKSLTTHMIEEGSLDEKGDIASL--------LDH-FSRVYGD--------- 777
H++ KK + ++ L D L +H + GD
Sbjct: 2247 HALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLK 2306
Query: 778 -PNGFKFRHAQDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSNSP 835
P+ + + N+ SLA S++ Y+L + DRH N+M+D G ++HIDFG +
Sbjct: 2307 SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAM 2366
Query: 836 GSVGF-EAAPFKLTYEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKD 894
F E PF+LT M + + + C + LR++ D ++++ E D
Sbjct: 2367 TREKFPEKIPFRLTRMLTNAMEVTGLDGNYRIT--CHTVMEVLREHKDSVMAVLEAFVYD 2424
Query: 895 SL 896
L
Sbjct: 2425 PL 2426
>CE28813 [L] KOG0891 DNA-dependent protein kinase
Length = 687
Score = 51.6 bits (122), Expect = 6e-06
Identities = 49/202 (24%), Positives = 86/202 (42%), Gaps = 32/202 (15%)
Query: 686 KSGDDLRQEAFACQLIQAMAAIWSKENV----GVWVKKMNILITSSHTGLVETITNAISV 741
K +D RQ+ QL + + + + + +++ +I+ S +GL+ + N ++
Sbjct: 353 KGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTL 412
Query: 742 HSIKK-----------SLTTHMIEEGSLD-EKGDIASLLDHFSRVYGDPNGFKFRHA--- 786
H++ K S+ +++ SL+ E + L F G RH
Sbjct: 413 HTLVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWL 472
Query: 787 -----------QDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSNS 834
+ N+ S+A S++ Y+L + DRH N+M+D G VVHIDFG +
Sbjct: 473 KSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVA 532
Query: 835 PGSVGF-EAAPFKLTYEYVEVM 855
F E PF+LT + M
Sbjct: 533 MLREKFPERVPFRLTRMLINAM 554
>CE07705 [L] KOG0891 DNA-dependent protein kinase
Length = 2697
Score = 51.6 bits (122), Expect = 6e-06
Identities = 49/202 (24%), Positives = 86/202 (42%), Gaps = 32/202 (15%)
Query: 686 KSGDDLRQEAFACQLIQAMAAIWSKENV----GVWVKKMNILITSSHTGLVETITNAISV 741
K +D RQ+ QL + + + + + +++ +I+ S +GL+ + N ++
Sbjct: 2363 KGHEDPRQDERVMQLFGLVNTLLANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTL 2422
Query: 742 HSIKK-----------SLTTHMIEEGSLD-EKGDIASLLDHFSRVYGDPNGFKFRHA--- 786
H++ K S+ +++ SL+ E + L F G RH
Sbjct: 2423 HTLVKEYREKKAKIPLSIEHKTLQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWL 2482
Query: 787 -----------QDNFASSLAAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSNS 834
+ N+ S+A S++ Y+L + DRH N+M+D G VVHIDFG +
Sbjct: 2483 KSPSSEVWFDRRTNYTRSVACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVA 2542
Query: 835 PGSVGF-EAAPFKLTYEYVEVM 855
F E PF+LT + M
Sbjct: 2543 MLREKFPERVPFRLTRMLINAM 2564
>Hs20336203 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 3056
Score = 51.2 bits (121), Expect = 7e-06
Identities = 32/108 (29%), Positives = 55/108 (50%), Gaps = 3/108 (2%)
Query: 790 FASSLAAYSIICYLLRIKDRHNGNIMIDNE-GHVVHIDFGFMLSNSPGSVGFEAAPFKLT 848
+ S+A SI+ Y+L + DRH NI+I+ + +VHID G E PF+LT
Sbjct: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLT 2911
Query: 849 YEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSL 896
+ V+ MG + E F C+ + +R + ++++ E++ D L
Sbjct: 2912 RDIVDGMGITGVEGV--FRRCCEKTMEVMRNSQETLLTIVEVLLYDPL 2957
>Hs20336199 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 1708
Score = 51.2 bits (121), Expect = 7e-06
Identities = 32/108 (29%), Positives = 55/108 (50%), Gaps = 3/108 (2%)
Query: 790 FASSLAAYSIICYLLRIKDRHNGNIMIDNE-GHVVHIDFGFMLSNSPGSVGFEAAPFKLT 848
+ S+A SI+ Y+L + DRH NI+I+ + +VHID G E PF+LT
Sbjct: 1504 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLT 1563
Query: 849 YEYVEVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSL 896
+ V+ MG + E F C+ + +R + ++++ E++ D L
Sbjct: 1564 RDIVDGMGITGVEGV--FRRCCEKTMEVMRNSQETLLTIVEVLLYDPL 1609
>At1g50030 [L] KOG0891 DNA-dependent protein kinase
Length = 2467
Score = 50.8 bits (120), Expect = 1e-05
Identities = 54/224 (24%), Positives = 92/224 (40%), Gaps = 25/224 (11%)
Query: 686 KSGDDLRQEAFACQLIQAMAAIWSKENV----GVWVKKMNILITSSHTGLVETITNAISV 741
K +DLRQ+ QL + + + +++ +++ S ++GL+ + N ++
Sbjct: 2101 KGHEDLRQDERVMQLFGLVNTLLENSRKTAEKDLSIQRYSVIPLSPNSGLIGWVPNCDTL 2160
Query: 742 HSIKKSLTTHMIEEGSLDEKGDIASLLDHFSRVYGDPNGFK-------FRHAQDNFASSL 794
H H+I E K + H D + F +A +N +
Sbjct: 2161 H--------HLIREHRDARKIILNQENKHMLSFAPDYDNLPLIAKVEVFEYALENTEGN- 2211
Query: 795 AAYSIICYLLRIKDRHNGNIMIDN-EGHVVHIDFGFMLSNSPGSVGF-EAAPFKLTYEYV 852
S + Y+L + DRH N+M+ G ++HIDFG S F E PF+LT V
Sbjct: 2212 -DLSRVGYILGLGDRHPSNLMLHRYSGKILHIDFGDCFEASMNREKFPEKVPFRLTRMLV 2270
Query: 853 EVMGGSESETFKKFVELCKAAFKALRKYADHIVSLCEIMQKDSL 896
+ M S E F C+ + LR D ++++ E D L
Sbjct: 2271 KAMEVSGIE--GNFRSTCENVMQVLRTNKDSVMAMMEAFVHDPL 2312
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.133 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,106,893
Number of Sequences: 60738
Number of extensions: 2119159
Number of successful extensions: 6235
Number of sequences better than 1.0e-05: 58
Number of HSP's better than 0.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 6021
Number of HSP's gapped (non-prelim): 121
length of query: 956
length of database: 30,389,216
effective HSP length: 116
effective length of query: 840
effective length of database: 23,343,608
effective search space: 19608630720
effective search space used: 19608630720
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)