ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII0750 good H KOG2544 Coenzyme transport and metabolism Dihydropteroate synthase/7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase/Dihydroneopterin aldolase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII0750 250633 253026 798
(798 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL256w [H] KOG2544 Dihydropteroate synthase/78-dihydro-6-hydrox... 774 0.0
SPBC1734.03 [H] KOG2544 Dihydropteroate synthase/78-dihydro-6-hy... 329 1e-89
At4g30000 [H] KOG2544 Dihydropteroate synthase/78-dihydro-6-hydr... 263 1e-69
At1g69190 [H] KOG2544 Dihydropteroate synthase/78-dihydro-6-hydr... 234 3e-61
>YNL256w [H] KOG2544 Dihydropteroate
synthase/78-dihydro-6-hydroxymethylpterin-
pyrophosphokinase/Dihydroneopterin aldolase
Length = 864
Score = 774 bits (1998), Expect = 0.0
Identities = 406/808 (50%), Positives = 552/808 (68%), Gaps = 34/808 (4%)
Query: 16 DQVHVKSLDVKAVVGPDSWDQLKPQNLKVTLHMQTDFKKSSITDDLKYSLNYAVVSRDIS 75
D VH+K L++ V+GPDSW+QL PQ ++L M TDF KS+ TDDLKYSLNYAV+SRD++
Sbjct: 62 DYVHIKKLEMNTVLGPDSWNQLMPQKCLLSLDMGTDFSKSAATDDLKYSLNYAVISRDLT 121
Query: 76 NHVQKNIKRNYKDVNTFGRNIVEYAKKSYPGINALTVEVESKEANIRSNSIKSTTSDSH- 134
N V K K+N+ V+ +++ ++ Y G+ L +EV++ +IRS+ I
Sbjct: 122 NFVSK--KKNWGSVSNLAKSVSQFVMDKYSGVECLNLEVQADTTHIRSDHISCIIQQERG 179
Query: 135 ----DELDHIIISDFKILTLIGVFTFERLKRQYVDFTIKLPIAEGSDVPQ-YDKIINQVT 189
E D + IS+ K+LTLIGVFTFERLK+QYV IKLP + +++P II+ V
Sbjct: 180 NPESQEFDVVRISELKMLTLIGVFTFERLKKQYVTLDIKLPWPKKAELPPPVQSIIDNVV 239
Query: 190 EYVENSNFKTVEALVETAAQVVLTNNGYFFDRPSLPIEVKVMKLNAITETEGVGVSCERC 249
++VE SNFKTVEALVE+ + V+ +N YF P P+ VKV+KLNAIT TEGVGVSC R
Sbjct: 240 KFVEESNFKTVEALVESVSAVI-AHNEYFQKFPDSPLVVKVLKLNAITATEGVGVSCIR- 297
Query: 250 YDDFKSVAPISLPVAKSKVINSCTGGDFDLPV-QNIKLD-KDSWKSAILAFGSNIGDRFK 307
+ + +A +++P S I+ + F L QN ++ K++WK A LAFGSNIGDRFK
Sbjct: 298 --EPREIAMVNIPYLSS--IHESSDIKFQLSSSQNTPIEGKNTWKRAFLAFGSNIGDRFK 353
Query: 308 NVVEAVSLLKAHKDVEVVCSSSLFESEPMYFKDQQPFLNGCIKIKTRLLPDALLELCKKI 367
++ A+ LL K V++ SS+FESEPMYFKDQ PF+NGC++++T L P LL+LCKKI
Sbjct: 354 HIQMALQLLSREKTVKLRNISSIFESEPMYFKDQTPFMNGCVEVETLLTPSELLKLCKKI 413
Query: 368 EYDELNRVKHFDNGPRTIDLDIVTYYDSNGADFSMNTPELTIPHPRMLERSFVLEPLCEL 427
EY+EL RVKHFDNGPRTIDLDIV + +S G D +N P+L IPHPRMLER+FVLEPLCEL
Sbjct: 414 EYEELQRVKHFDNGPRTIDLDIVMFLNSAGEDIIVNEPDLNIPHPRMLERTFVLEPLCEL 473
Query: 428 ISPCCVHPITAEPIHNHLKQLYENDNPEDVLWKLVP------VGDKFLKFKIQWEKDILT 481
ISP +HP+TAEPI +HLKQLY+ + ED LWKLVP V +FLKFK + D T
Sbjct: 474 ISPVHLHPVTAEPIVDHLKQLYDKQHDEDTLWKLVPLPYRSGVEPRFLKFKTATKLDEFT 533
Query: 482 GLRRPVSSSSAYLMGVVNVTPDSFSDGAQDYDNKEVVVSKIEAMVSAALELHEIVILDIG 541
G ++ S Y+M + N TPDSFSDG + + + E ++ I + AL LHE VI+D+G
Sbjct: 534 GETNRITVSPTYIMAIFNATPDSFSDGGEHFADIESQLNDIIKLCKDALYLHESVIIDVG 593
Query: 542 GCSTRPGSLQASEEEELARILPIINAVTTSKSIPLDKVVISIDTYRSVVAEAAISAGVGI 601
GCSTRP S+QASEEEE+ R +P+I A+ S +P DKV++SIDTYRS VA+ AI GV I
Sbjct: 594 GCSTRPNSIQASEEEEIRRSIPLIKAIRESTELPQDKVILSIDTYRSNVAKEAIKVGVDI 653
Query: 602 INDISGGVFDPRILQVVSKHPNVAYVLSHIRGTIDSMSSETSY---LTSDENVKEYISGK 658
INDISGG+FD + V++++P + Y+LSH RG I +M+ Y D +E++
Sbjct: 654 INDISGGLFDSNMFAVIAENPEICYILSHTRGDISTMNRLAHYENFALGDSIQQEFVHNT 713
Query: 659 EGNEIDNL-----FIKTIGREVCSRYQDTFRNNIFRWQLFLDPGIGFAKVGKQNLELIKG 713
+ ++D+L I+ +G+E+ RY N + RWQ+ +DPG+GFAK KQNL++I+
Sbjct: 714 DIQQLDDLKDKTVLIRNVGQEIGERYIKAIDNGVKRWQILIDPGLGFAKTWKQNLQIIRH 773
Query: 714 IPLLRNYSCIIGNE----YYSLINLPVLVGPSRKKFIGDITKTPSAKDRDFATGAIVSAC 769
IP+L+NYS + + Y +L N+PVL+GPSRKKFIG ITK AK RDFATGA+V++C
Sbjct: 774 IPILKNYSFTMNSNNSQVYVNLRNMPVLLGPSRKKFIGHITKDVDAKQRDFATGAVVASC 833
Query: 770 VANGCDIIRVHDVANISKALKLLNELYR 797
+ G D++RVHDV N SK++KL + +Y+
Sbjct: 834 IGFGSDMVRVHDVKNCSKSIKLADAIYK 861
>SPBC1734.03 [H] KOG2544 Dihydropteroate
synthase/78-dihydro-6-hydroxymethylpterin-
pyrophosphokinase/Dihydroneopterin aldolase
Length = 686
Score = 329 bits (843), Expect = 1e-89
Identities = 248/786 (31%), Positives = 386/786 (48%), Gaps = 113/786 (14%)
Query: 15 HDQVHVKSLDVKAVVGPDSWDQLKPQNLKVTLHMQTDFKKSSITDDLKYSLNYAVVSRDI 74
HD V V++L+ AVVG D W + +PQ +++ ++M+ + + + D+LK +++Y + S+ +
Sbjct: 5 HDTVVVENLNTFAVVGQDQWKRKEPQPVQIDVYMRNNVQLAGEKDELKSTIHYGIASKLL 64
Query: 75 SNHVQKNIKRNYKDVNTFGRNIVEYAKKSYPGINALTVEVESKEANIRSNS-----IKST 129
++ + KD+ I + + +++++ + +RS + +
Sbjct: 65 RKEIEGSFFTTPKDLVN---KIASLCFEDVIDTSHVSIKLTLPKCVLRSKNGLHYYAERE 121
Query: 130 TSDSHDELDHIIISDFKILTLIGVFTFERLKRQYVDFTIKLPIAEGSDVPQYDKIINQVT 189
+ + + +D I SD ++ T++G+ FER ++Q V I E + +I +
Sbjct: 122 RNSTSNFVDRIEFSDLELATILGIHAFERQEKQRVCLNISFANTEVEAL----EIARAIA 177
Query: 190 EYVENSNFKTVEALVETAAQVVLTNNGYFFDRPSLPIEVKVMKLNAITETEGVGVSCERC 249
EYVE S F T+EALV ++ + F + I +K K +AIT V R
Sbjct: 178 EYVEQSAFLTIEALVVNLSKYLC------FTKNLDDISIKAEKPSAITFANASAVQIYRT 231
Query: 250 YDDFKSVAPISLPVAKSKVINSCTGGDFDLPVQNIKLDKDSWKSAILAFGSNIGDRFKNV 309
F + K+K+ A L+FGSNIGD+F+ +
Sbjct: 232 RSYFLQESLHKYESTKNKI-------------------------AYLSFGSNIGDKFEQI 266
Query: 310 VEAVSLLKAHKDVEVVCSSSLFESEPMYFKDQQPFLNGCIKIKTRLLPDALLELCKKIEY 369
A+S+L + + V+ S L+E+EPMY+KDQ FLNG KI+TR+ P LL C+ IE
Sbjct: 267 QTALSMLHKIEGIRVLDVSPLYETEPMYYKDQPSFLNGVCKIETRMSPINLLRACQSIE- 325
Query: 370 DELNRVKHFDNGPRTIDLDIVTYYDSNGADFSMNTPELTIPHPRMLERSFVLEPLCELIS 429
E+ R+K GPR IDLDIV Y D + LTIPH + ER FVL PL L S
Sbjct: 326 QEMGRIKTILKGPRCIDLDIVLYEDC-----VYESEVLTIPHLGLQEREFVLRPLLAL-S 379
Query: 430 PCCVHPITAEPIHNHLKQLYENDNPEDVLWKLVPVGDKFLKFKIQWEKDILTGLRRPVSS 489
P VHP T +P+ ++ L KL G + + K I+ G
Sbjct: 380 PDLVHPYTHQPL-------------QEALDKLPSQGIRL--YSSFDNKKIING------- 417
Query: 490 SSAYLMGVVNVTPDSFSDGAQDYDNKEVVVSKIEAMVSAALELHEIVILDIGGCSTRPGS 549
A MG++NVTPDSFSDG + N ++ K ++MV ILDIGG ST+PG+
Sbjct: 418 --ALTMGILNVTPDSFSDGGKVSQNN--ILEKAKSMVGDGAS-----ILDIGGQSTKPGA 468
Query: 550 LQASEEEELARILPIINAVTTSKSIPLDKVVISIDTYRSVVAEAAISAGVGIINDISGGV 609
S EEEL R++P+I+ + +S V ISIDTY S VA+ AI AG IIND++GG+
Sbjct: 469 DPVSVEEELRRVIPMISLLRSSGIT----VPISIDTYYSKVAKLAIEAGANIINDVTGGM 524
Query: 610 FDPRILQVVSKHPNVAYVLSHIRGTIDSMSSETSYLTSDENVKEYISGKEGNEIDNLFIK 669
D ++L + + V + H+RGT ++M + + Y + ++
Sbjct: 525 GDEKMLPLAASL-QVPICIMHMRGTPETMKALSIY-------------------EKDIVE 564
Query: 670 TIGREVCSRYQDTFRNNIFRWQLFLDPGIGFAKVGKQNLELIKGIPLLRNYSCIIGNEYY 729
+ E+ SR + ++ + R+ + LDPG GFAK KQ+ L+ + L
Sbjct: 565 EVAVELSSRVEAAVQSGVHRYNIILDPGFGFAKTPKQSAGLLGRLHELMKKP-------- 616
Query: 730 SLINLPVLVGPSRKKFIGDITKTPSAKDRDFATGAIVSACVANGCDIIRVHDVANISKAL 789
++ L GPSRK F G T S KDR + T A V+A V G I+RVHD +SK +
Sbjct: 617 QFKDMHWLSGPSRKGFTGYFTGDASPKDRIWGTSACVTASVLQGVSIVRVHDTKEMSKVV 676
Query: 790 KLLNEL 795
+ N +
Sbjct: 677 GMANAI 682
>At4g30000 [H] KOG2544 Dihydropteroate
synthase/78-dihydro-6-hydroxymethylpterin-
pyrophosphokinase/Dihydroneopterin aldolase
Length = 554
Score = 263 bits (671), Expect = 1e-69
Identities = 179/514 (34%), Positives = 282/514 (54%), Gaps = 66/514 (12%)
Query: 295 ILAFGSNIGDRFKNVVEAVSLLKAHKDVEVVCSSSLFESEPMYFKDQQPFLNGCIKIKTR 354
++A GSNIG+R N EA+ L+K + V S L+E+ P++ DQ FLN ++ T+
Sbjct: 90 VIALGSNIGNRMNNFREALRLMK-RGGICVTRHSCLYETAPVHVTDQPRFLNAAVRGVTK 148
Query: 355 LLPDALLELCKKIEYDELNRVKHFDNGPRTIDLDIVTYYDSNGADFSMNTPELTIPHPRM 414
L P LL + K IE D + R GPR +DLDI+ Y +++ +L IPH R+
Sbjct: 149 LGPHELLSVLKTIERD-MGRKDGIRYGPRPLDLDILFY-----GKMRISSDKLIIPHERL 202
Query: 415 LERSFVLEPLCELISPCCVHPITAE----PIH-NHLKQLYENDNPE-----DVLWKLVPV 464
ERSFVL PL +L+ + A IH + Q +E E D + +++P+
Sbjct: 203 WERSFVLAPLVDLLGSAVDNDTVAHWHSLAIHPGGIFQAWERLGGESLIGQDGIQRVLPI 262
Query: 465 GDKFLKFKIQWEKDILTGLRRPVSSSSAYLMGVVNVTPDSFSDGAQDYDNKEVVVSKIEA 524
GDK F S+ ++MG++N+TPDSFSDG + + + + VS++ +
Sbjct: 263 GDKLWDF-----------------SNKTHVMGILNLTPDSFSDGGK-FQSIDSAVSRVRS 304
Query: 525 MVSAALELHEIVILDIGGCSTRPGSLQASEEEELARILPIINAVTTSKSIP-LDKVVISI 583
M+S + I+DIG STRP + + S +EEL R+LP++ AV + +P +++ +IS+
Sbjct: 305 MISEGAD-----IIDIGAQSTRPMASRISSQEELDRLLPVLEAV---RGMPEMEEKLISV 356
Query: 584 DTYRSVVAEAAISAGVGIINDISGGVFDPRILQVVSKHPNVAYVLSHIRGTIDSMSSETS 643
DT+ S VA AIS G I+ND+S G DP + +VV++ V Y+ H+RG +M +
Sbjct: 357 DTFNSEVASEAISNGADILNDVSAGTLDPNMHKVVAES-GVPYMAMHMRGDPCTMQN--- 412
Query: 644 YLTSDENVKEYISGKEGNEIDNLFIKTIGREVCSRYQDTFRNNIFRWQLFLDPGIGFAKV 703
KE + D++ K + E+ R +D + I W++ +DPGIGF+K
Sbjct: 413 --------------KENLQYDDV-CKDVASELYLRVRDAELSGIPAWRVMIDPGIGFSKS 457
Query: 704 GKQNLELIKGIPLLRNYSCIIGNEYYSLINLPVLVGPSRKKFIGDITKTPSAKDRDFATG 763
NL++I +P +R + ++ + P+LVGPSRK+F+GDI P A DRD AT
Sbjct: 458 VDHNLDIIMDLPKIREE---MAKRSIAVSHAPILVGPSRKRFLGDICGRPEATDRDAATV 514
Query: 764 AIVSACVANGCDIIRVHDVANISKALKLLNELYR 797
A V+A + G +IIRVH+V + + A K+ + + R
Sbjct: 515 ASVTAGILGGANIIRVHNVRHNADAAKVCDAMLR 548
>At1g69190 [H] KOG2544 Dihydropteroate
synthase/78-dihydro-6-hydroxymethylpterin-
pyrophosphokinase/Dihydroneopterin aldolase
Length = 459
Score = 234 bits (598), Expect = 3e-61
Identities = 165/501 (32%), Positives = 262/501 (51%), Gaps = 66/501 (13%)
Query: 308 NVVEAVSLLKAHKDVEVVCSSSLFESEPMYFKDQQPFLNGCIKIKTRLLPDALLELCKKI 367
N EA+ L+K + + V S L+E+EP++ DQ FLN I+ T+L P LL + KKI
Sbjct: 3 NFKEALRLMKDY-GISVTRHSCLYETEPVHVTDQPRFLNAAIRGVTKLKPHELLNVLKKI 61
Query: 368 EYDELNRVKHFDNGPRTIDLDIVTYYDSNGADFSMNTPELTIPHPRMLERSFVLEPLCEL 427
E + GPR +DLDI+ Y + + +L IPH R+ ER FVL PL +L
Sbjct: 62 EKEMGREENGLRYGPRPLDLDILFY-----GKHKIISDKLIIPHERIWERPFVLAPLVDL 116
Query: 428 ISPCCVHPITAEPIHNHLK-------QLYENDNPEDVLWK------LVPVGDKFLKFKIQ 474
+ + + L Q +E E +L K ++P+GD F
Sbjct: 117 LGTEDIDNDKIVAYWHSLSMHSGGIFQAWERLGGESLLGKDGIIQRVIPIGDHLWDF--- 173
Query: 475 WEKDILTGLRRPVSSSSAYLMGVVNVTPDSFSDGAQDYDNKEVVVSKIEAMVSAALELHE 534
S Y+MG++N+TPDSFSDG + + + + VS++ +M+S ++
Sbjct: 174 --------------SKKTYVMGILNLTPDSFSDGGK-FQSVDTAVSRVRSMISEGVD--- 215
Query: 535 IVILDIGGCSTRPGSLQASEEEELARILPIINAVTTSKSIPLDKVVISIDTYRSVVAEAA 594
I+DIG STRP + + S +EE+ R++P++ V + +IS+DT+ S VA A
Sbjct: 216 --IIDIGAQSTRPMASRISSQEEIDRLIPVLKVVRGMAE--MKGKLISVDTFNSEVALEA 271
Query: 595 ISAGVGIINDISGGVFDPRILQVVSKHPNVAYVLSHIRGTIDSMSSETSYLTSDENVKEY 654
I G I+ND+SGG D + +VV+ +V Y++ H+RG +M ++ EN+
Sbjct: 272 IRNGADILNDVSGGSLDENMHKVVADS-DVPYMIMHMRGDPCTMQNK-------ENL--- 320
Query: 655 ISGKEGNEIDNLFIKTIGREVCSRYQDTFRNNIFRWQLFLDPGIGFAKVGKQNLELIKGI 714
E NEI K + E+ R ++ + I W++ +DPGIGF+K NL+++ +
Sbjct: 321 ----EYNEI----CKDVATELYERVREAELSGIPAWRIMIDPGIGFSKGIDHNLDIVMEL 372
Query: 715 PLLRNYSCIIGNEYYSLINLPVLVGPSRKKFIGDITKTPSAKDRDFATGAIVSACVANGC 774
P +R + + L + P+L+GPSRK+F+GDI P A +RD AT A V+A + G
Sbjct: 373 PKIREE---MAKKSIGLSHAPILIGPSRKRFLGDICGRPEASERDAATVACVTAGILKGA 429
Query: 775 DIIRVHDVANISKALKLLNEL 795
+IIRVH+V + A +L + +
Sbjct: 430 NIIRVHNVRDNVDAARLCDAM 450
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.136 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,338,856
Number of Sequences: 60738
Number of extensions: 2143615
Number of successful extensions: 5567
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 5530
Number of HSP's gapped (non-prelim): 6
length of query: 798
length of database: 30,389,216
effective HSP length: 114
effective length of query: 684
effective length of database: 23,465,084
effective search space: 16050117456
effective search space used: 16050117456
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)