ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII0840 good S KOG1822 Function unknown Uncharacterized conserved protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII0840 286687 282254 -1478
(1478 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJL207c [S] KOG1822 Uncharacterized conserved protein 601 e-171
SPBC27B12.08 [S] KOG1822 Uncharacterized conserved protein 95 9e-19
Hs14735533 [S] KOG1822 Uncharacterized conserved protein 54 1e-06
Hs20482245 [S] KOG1822 Uncharacterized conserved protein 52 7e-06
>YJL207c [S] KOG1822 Uncharacterized conserved protein
Length = 2014
Score = 601 bits (1549), Expect = e-171
Identities = 455/1626 (27%), Positives = 768/1626 (46%), Gaps = 177/1626 (10%)
Query: 7 SLTERLASSEGKRATFINWITESLSCKTLNTADVLDDTV-----------EFLRSIIVAE 55
SL + + +S + WIT +L K + +V D+ + EF+R I V E
Sbjct: 5 SLKKVIETSSNNGHDLLTWITTNLE-KLICLKEVNDNEIQEVKEIHTQLDEFVRYISVLE 63
Query: 56 DRDVVEYESKVISYQLSNLCVLCLKDLYQEKPGKVYDFAGFLCNILCENYEEVVQG---P 112
+ D +E S IS LS L + + L E PG V+D A FL N+LCE + G P
Sbjct: 64 NTDDLELHSVFIS--LSQLYTISIWRLKDEYPGVVFDSAAFLTNVLCEEDVSIDDGDTDP 121
Query: 113 ALKKRFKKH---KSTHLYSVVKDYAITILCHLYACFSEDLHSLSAMIIPVLFKDLKKVLE 169
KK+ KK K ++YS KD A TIL L+ F + SL ++ +FK+LKK++E
Sbjct: 122 NQKKKKKKSSTKKKKYIYSPAKDIACTILVQLFENFGSSISSLIPLLFNAIFKNLKKIME 181
Query: 170 KPKYFNSNYAIFLMRLFQTISMYNSNN---AIDDHYHQKYLKLVKDVFSDISDERVDYPS 226
K KY+++ + L++LF I + NSNN +D + K+ KL K VF IS + D+
Sbjct: 182 KSKYYHATFMTTLLQLFNAI-LRNSNNDDKILDPATYAKFSKLSKTVFDSISTDEKDFSV 240
Query: 227 DFVSSLVENLTGYFESNYFVKAHKNDFLDVMRSNINS--ILTVCVKCPKWRIAIAESLAK 284
FVS L+E T +F+ F++ H +D ++ + S I + RI A+SLA+
Sbjct: 241 TFVSVLIECWTAHFKQTNFIREHSHDIIETIYSRFTEGEIGVYGFANDETRIFTAKSLAE 300
Query: 285 IL-GYYVSVDLMEPKVACEFYGNLFCSLNFKAGRIAILESLHQFMFVNFTRNTKFLMGDK 343
IL YY S +++ + Y +F + + + ES+ + +N + FL K
Sbjct: 301 ILFDYYFSKNILTLQEVWSIYVKIFLNCDTRDVESGCFESIIHLINLNLLADNTFLSNSK 360
Query: 344 YLSLFQCFVECLCRCGIVISIED-----------IELFNLVHNQTLPFLTDSARTSVIDE 392
YL + L G+ S E + F +H LP L DSA+T ++
Sbjct: 361 YLDIV------LSLSGVFSSYEVNNRSMNTLSRYLRYFQHMHEVILPHLNDSAKTQMLYY 414
Query: 393 IFNAADRYILSDNLEQTQSI-----------------LGLLSVFFRDLPANVIADRGLGE 435
I +D Y S + + L V DL + + +
Sbjct: 415 ILGCSDTYQSSSKSDSASNFKYSIDAKPETQWLTLLQLDFTYVLISDLGSTFTTEENTVK 474
Query: 436 KIQASLLKVSAVENLTVRINSVYCLQLFLHSVPYKIPGVVDELLEKLSSQFQIEKGFSFA 495
+I+ L+ ++ E T+R+++V L++FL++ P + ++ L LS+ F+ F F
Sbjct: 475 EIRDKLVDLATCEIFTIRVHTVEILKVFLNNCPEYLSETIENSLRALSTDFKSTGKFIFH 534
Query: 496 GNHGICLLISSIITSRDPDFVSFDLIMRVTAFAVGTLKSNSLSTKKVLYEKELLCWILLT 555
NHG +I+++I + D++S++LIMR+T F+ +K+N+ ST LY K LLCWILL
Sbjct: 535 KNHGHAFIIANLIKGAESDYISYELIMRITVFSTSFIKNNTTSTSSNLYFKGLLCWILLI 594
Query: 556 GALCFQDEKYIKTHSPQLFIFWRNIFTHSAVYHTEDELMKNIEIRNHALSCMISFLRSSV 615
G + ++DE+Y+K PQLF+FW+ + TH+ YH EDEL KN+EIRNHAL+C++++L ++
Sbjct: 595 GLMNYKDEQYLKLQIPQLFLFWKVLLTHTYTYHDEDELYKNLEIRNHALTCLLTYLSNTT 654
Query: 616 LNEELSKQVFYLISKCLNFKHSVTAVSGSMKELLARYEHRMYQVFLLICPYVHKDVSTSA 675
+++E++KQV YL++KC NF HS+ S ++ L E+R+ QV+L + Y++ D ++S
Sbjct: 655 IDKEMAKQVSYLLTKCSNFNHSIDLKSKNIDNALLHNENRILQVYLKLEKYINSDFNSSL 714
Query: 676 LLQALKNFSNPVNCFEDGCLHV----------SAPQKAEEVARFPAVGRFSDVLTCSESA 725
L+ +KNFS+P N + + V K + + + +L +
Sbjct: 715 LILIVKNFSDP-NLYTESSSSVLGSLKDIGNRKVSNKDDMESNIVLESSINTLLRQNNGF 773
Query: 726 DYGVSTFV--------------KSVQSFGTSKPC-------LLEEAWEKPVVTSRSFD-- 762
+G+S+ + K +S S P + E KP+ S D
Sbjct: 774 AFGLSSKITGDRIVNLSMSSAYKYDESISGSWPSKDYNWYNIFEVEVSKPISPILSLDSL 833
Query: 763 --------YNHVILNLSPPVPYSIALIDVSLELFSLCFPFTSQSVQRSLIETLISNVLTN 814
Y+ I +P V + +LID S+ELFS FPF + +Q S++ETL ++ +
Sbjct: 834 ILLYGSGSYSQ-IDRYAPQV--TTSLIDSSMELFSSVFPFLNSKIQYSIMETLNLSMFSK 890
Query: 815 SHTRHKYSVVKANVLFAMYMALVEVDRCKLGVHCTIGELIINVLDECSFSDDDILYDLKG 874
T + V ANV A++ AL + L + ++G+LII + + F +D L +K
Sbjct: 891 MTTPLRSVAVAANVCSALHNALRIMQENNLELDYSVGQLIIESIKKIQFFNDIFLTKIKA 950
Query: 875 RCFGFVCAAVKRT-GDEKFSKSLINVS---IQRIVSDVNPISRGLNLFIICNILNEDPGC 930
C G + AA+ RT GDE+ K L S I+ + P R ++ + I +
Sbjct: 951 DCVGLLTAAIARTLGDEERQKFLTEQSRIFIKNVADMDEPYLRMFHVLSLATIFKYNSQY 1010
Query: 931 SEFAVVLDIVKKFISDPHPVINVSGLKCLFVLLKKHNICDIRLAGELLELISVNLFCNNY 990
+ F D++ + DPHPV++ LK + +LL+KH + D++ A LL + L + Y
Sbjct: 1011 ANFEEYFDVIFALMRDPHPVVHSWSLKAMHILLEKHLVIDLKTAALLLSSMEELLVQDKY 1070
Query: 991 GPFSTLSFGNNYCQKFNPGIVICFIVSALVAMLGPGVLGFDDSKRSLLKGIILALQFSPF 1050
G + + NY + FN + I I L +GP L + + I L++ S
Sbjct: 1071 GIYGRSTLRCNYNRDFNSHVAIGEISRTLTETVGPNFLELNTKVLDSFRNITLSMLISNN 1130
Query: 1051 DGVQTSSLKICETLSLFKLNEFFCLKLSLNVVKSRILSLLRQNVGSGYLALYDDRSSAGY 1110
+S+K+ E ++ FK+ ++ + KS I S + +GS Y D + G
Sbjct: 1131 ILNSITSIKMFENIATFKMKNILNYEIFILASKSIIKSSIVTGIGSSYF----DTTFTGS 1186
Query: 1111 CSSESFTVSVQ-------YLCELAKLQVYDIYIDASLSQLCWGALLVFPKSRLLRSYLEG 1163
S T S++ L L KLQ+ + ++ + L W L +FP S +++Y
Sbjct: 1187 NELISRTSSLKGAFENFDLLTLLYKLQMEEFFM-KEMENLSWRYLALFPNSGSVKNYFTE 1245
Query: 1164 WCMFQVKNSVNVFKVLIRLFDMCFAEYMSLMYYRGREEHIFLDDNFLFEEEQDISVGCFQ 1223
W + K + F L +F+M L R+ L+ N L + + G +
Sbjct: 1246 WILHTFKRDNHWFDKLYSIFNMSLGR---LFQSYNRDVSALLEVNGLKKSSEKEIKGEEE 1302
Query: 1224 ESAV--------------KESVGSFSRQFIVEL-MSGCVKLLVGSKKALELLPEMSAIIK 1268
ES E++ SRQ I+ L + C++ L L +++ +IK
Sbjct: 1303 ESIANVNQLTDTDAGGLDSENLQWKSRQIILNLILMLCLESEKYENLLLALSNKIADLIK 1362
Query: 1269 VCFFCCSSEVAWLQISALGLLKCILNVYGEMVDKEDESSFVLEQYSAVLSGAVLPIFMKP 1328
+ F + ++++ L +L +L Y M D + S +LEQ A ++ A++P F K
Sbjct: 1363 ISFRGSTVRNEGMKLTGLHILNFVLKNYSTMRDPQVPGSSILEQQEAQITSALMPAFSKG 1422
Query: 1329 SYPKVICEGIDVCAEIVGCGLVPYSDDDRVVNVLVESLLEIAGNKTEIKVGCSTFQLTKR 1388
S P V+ I V AE++ ++P R+ +L++ L + I++G + K
Sbjct: 1423 SSPTVMSFAITVAAEVLASNIMPPDKLGRISQLLIDLLGNFKDPNSGIRIGEAIIVTPKA 1482
Query: 1389 QQEVKHSILKGWGILECKSYQNKNEELEKFVKEYLNVLVPLWIITIR------------- 1435
+++++ ++L W + +S + N+ L F ++Y ++LVPLWII++R
Sbjct: 1483 KRKIELAVLDAWAEVVQRSITSSNDALFSFTRKYWSILVPLWIISLREYMMIKYNDNDST 1542
Query: 1436 --------------------ELHSPVWLKIVDSLCAVQSQDPSII----NNFDLEGFVFV 1471
EL+ PVWL V++L D +I N+ +LE F+F+
Sbjct: 1543 VQVKNDSKENSLIEPRSTKIELYEPVWLNFVEALGCTLDSDVQVILASLNDEELEYFLFI 1602
Query: 1472 MFGEIL 1477
+F + L
Sbjct: 1603 LFSQCL 1608
>SPBC27B12.08 [S] KOG1822 Uncharacterized conserved protein
Length = 1919
Score = 94.7 bits (234), Expect = 9e-19
Identities = 175/915 (19%), Positives = 361/915 (39%), Gaps = 108/915 (11%)
Query: 497 NHGICLLISSIITSRDPDFVSFDLIMRVTAFAVGTLKSNSLSTKKVLYEKELLCWILLTG 556
N + L+ + +P +V+ + ++ F++ +KS+S + W LL+
Sbjct: 498 NLTLSLMSIYVAAEENPLYVASSIFSKLFNFSLDLIKSSSKLDLLAAQAQIKTGWRLLSA 557
Query: 557 ALCFQDEKYIKTHSPQLFIFWRNIFTH-SAVYHTEDELMKNIEIRNH--ALSCMISFLRS 613
+ F + + QL I W+N + + H+++ + N ++ N AL C++SFL
Sbjct: 558 YVSF-GPSFTRMQLSQLLILWKNALSRVPSKIHSQNFMETNADMFNRFEALQCLLSFLEY 616
Query: 614 S--VLNEELSKQVFYLISKCLNFKHS------------VTAVSGSMKELLARYEHRMYQV 659
+ + ++ K+V ++ CL F + + A S EL + R++Q
Sbjct: 617 NKILFTPDVRKRVIIFLNNCLKFYKAFSLTKRLEITMPIPASDYSHLELRSLLLARIFQC 676
Query: 660 FLLICPYVHKDVSTSALLQALKNFSNPVNCFEDGCLHVSAPQKAEEVARFPAVGRFSDVL 719
F + + LL + ++ + A+E+ + A +
Sbjct: 677 FFELSQLSGMSLDDQELLSTTVSTIAELSSLQ-------GYDTADEIVQAKAFTSPRVI- 728
Query: 720 TCSESADYGVSTFVKSVQSFGTSK----PCLL-EEAWEKPVVTSRSFDYNHVILNLSPPV 774
G + + + F T+ PC + E + + V SRS N L PP
Sbjct: 729 -----PGIGSRFYAQPEEEFQTTMDDILPCYICESSSDSLSVISRS---NSAKLPYVPPS 780
Query: 775 PYSIALIDVSLELFSLCFPFTSQSVQRSLIETLISNVLTNSHTRH--KYSVVKANVLFAM 832
S LID +++LF+ F V S +E ++++V R +Y V AN LF++
Sbjct: 781 LTS--LIDNAIQLFASMFCHQPPKVMESTLEIMVASVTNLKSGRDILRYKAVTANTLFSI 838
Query: 833 YMALVEVDRCKLGVHCTIGELIINVLDECSFSDDDILYDLKGRCFGFVCAAVKRTGDEKF 892
Y L D K+ + + L+I +L+ + +D L + + F+ +
Sbjct: 839 YGFLSAFDNKKVTLPDKVVSLMIELLENLTAVNDPKLIPYISKSYAFLAYLYQSK----- 893
Query: 893 SKSLINVSIQRIVSDVNPISRGLNLFIICNILNE-DPGCSEFAVVL--DIVKKFISDPHP 949
S+++ I+R +P R + + + +IL + G + ++ ++K F +D +
Sbjct: 894 PTSVLDTIIKRAAESGDPNCRAVLILAVGHILKKVGSGVPQTTLITAYQLLKVFNTDSND 953
Query: 950 VINVSGLKCLFVLLKK--HNICDIRLAGELLELISVNLFCNNYGPFSTLSFGNNYCQKFN 1007
++ ++ V L I + L + L+S L L N+ F
Sbjct: 954 LVRECSIRASSVSLGSIAKTIPSV-LTAQTRILLSYMLLPECDIDVQLLKKRNSL---FF 1009
Query: 1008 PGIVICFIVSALVAMLGPGVLGFDDSKRSL--LKGIILALQFSPFDGVQTSSLKICETLS 1065
P + + L+ LGP + + L +L L D + K + L
Sbjct: 1010 PSTLFANYLDCLINELGPNLRSDSSTSHFAFDLAHQLLLLSRDTGDNI-IHVYKCYQHLY 1068
Query: 1066 LFKL----NEFFCLKLSLNVVKSRILSLLRQNVGSGYLALYDDRSSAGYCSSESFTVSVQ 1121
LF ++FF +L N++ + ++ Y L + + C F
Sbjct: 1069 LFTPLETNSDFFIRELCGNIIDLKQPKRREISIEVLYQILLQNHEFSESCYKRHF----- 1123
Query: 1122 YLCELAKLQVYDIYIDASLSQLCWGALLVFPKSRLLRSYLEGWCM----FQVKNSVNVFK 1177
+L W +L P ++LL++ L W + + VN+
Sbjct: 1124 -------------------DRLIWQSLDTTPDNKLLKNILYIWLNDYKDSDIHSWVNILL 1164
Query: 1178 VLIRLFDMCFAEYMSLMYYRGREEHIFLDDNFLFEEEQDISVGCFQESAVKESVGSFSRQ 1237
L+ + + +E R E+ I N L E+ ++ G + ++ ++ Q
Sbjct: 1165 FLVGIKNTSSSE-------RSNEQDI---QNNLDEDTVSLAYGTSENASNPLFQKNYRWQ 1214
Query: 1238 ---FIVELMSGCVKLLVGSKK--ALELLPEMSAIIKVCFFCCSSEVAWLQISALGLLKCI 1292
+ + C+ ++ K A L+ +S +++ F +S+ +L+ LL I
Sbjct: 1215 TQFYAATCLKTCISEVMAENKEPAKYLISRISDLVRAAFVLSTSDNFYLKQGGFELLDTI 1274
Query: 1293 LNVYGEMVDKEDESSFVLEQYSAVLSGAVLPIFMKPSYPKVICEGIDVCAEIVGCGLV-P 1351
+ + ++D + + +L+Q+ A +S A F+ S P+++ +++ + +G GL+
Sbjct: 1275 ITDFSNVMDPDFDDVSLLDQFQAQISSAFSSAFVDDSSPEIVAMSLNIASNFIGTGLLKT 1334
Query: 1352 YSDDDRVVNVLVESL 1366
S +++N+L E+L
Sbjct: 1335 ESQAAKILNLLKEAL 1349
>Hs14735533 [S] KOG1822 Uncharacterized conserved protein
Length = 1564
Score = 54.3 bits (129), Expect = 1e-06
Identities = 42/162 (25%), Positives = 76/162 (45%), Gaps = 9/162 (5%)
Query: 1259 LLPEMSAIIKVCFFCCSSEVAWLQISALGLLKCILNVYGEMVDKEDESSFVLEQYSAVLS 1318
L+ +S +I++ F + L+++ L L+ I+ + + + E +LEQY A +
Sbjct: 781 LVLHLSDLIRMAFMAATDHSNQLRMAGLQALEDIIKKFASVPEPEFPGHVILEQYQANVG 840
Query: 1319 GAVLPIFMKPSYPKVICEGIDVCAEIVGCGLV-PYSDDDRVVNVLVESLLEIAGNKTEIK 1377
A+ P F + + +I + VC+ +G G+V +D RV N+LV SL ++ K
Sbjct: 841 AALRPAFSQDTPSDIIAKACQVCSTWIGSGVVSDLNDLRRVHNLLVSSLDKVQAGKG--- 897
Query: 1378 VGCSTFQLTKRQQEV--KHSILKGWGILECKSYQNKNEELEK 1417
S+ QL + K ++LK W + + K E K
Sbjct: 898 ---SSSQLYRESATTMEKLAVLKAWAEVYVVAMNIKKEAESK 936
>Hs20482245 [S] KOG1822 Uncharacterized conserved protein
Length = 1753
Score = 52.0 bits (123), Expect = 7e-06
Identities = 39/166 (23%), Positives = 76/166 (45%), Gaps = 16/166 (9%)
Query: 1259 LLPEMSAIIKVCFFCCSSEVAWLQISALGLLKCILNVYGEMVDKEDESSFVLEQYSAVLS 1318
L+ ++ +I++ F + L++S L +L ++ + + + E +LEQY A +
Sbjct: 973 LVLHLADLIRMAFMAATDHSDQLRLSGLEMLLVVIRRFATVPEPEFPGHVILEQYQANVG 1032
Query: 1319 GAVLPIFMKPSYPKVICEGIDVCAEIVGCGLV-PYSDDDRVVNVLVESLLEIAGNKTEI- 1376
A+ P F + P V + VC+ + G+V +D RV +LV SL +I K +
Sbjct: 1033 AALRPAFTSETPPDVTAKACQVCSAWIASGVVSDLNDLRRVHQLLVSSLTKIQAGKEALS 1092
Query: 1377 ---KVGCSTFQLTKRQQEVKHSILKGWG---ILECKSYQNKNEELE 1416
ST ++ ++LK W I+ + ++N + L+
Sbjct: 1093 HLYNESASTMEIL--------AVLKAWAEVYIIAVQRHKNHRQPLK 1130
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.325 0.140 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,176,949
Number of Sequences: 60738
Number of extensions: 3702772
Number of successful extensions: 11147
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 11124
Number of HSP's gapped (non-prelim): 15
length of query: 1478
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1359
effective length of database: 23,161,394
effective search space: 31476334446
effective search space used: 31476334446
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)