ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII0885 suspect: HSP T KOG3417 Signal transduction mechanisms Ras1 guanine nucleotide exchange factor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII0885 303739 307818 1360
(1360 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YCR038c [T] KOG3417 Ras1 guanine nucleotide exchange factor 115 6e-25
YLR310c [T] KOG3417 Ras1 guanine nucleotide exchange factor 90 2e-17
Hs7662070 [T] KOG3417 Ras1 guanine nucleotide exchange factor 80 2e-14
7294445 [T] KOG3629 Guanine-nucleotide releasing factor 80 2e-14
Hs8922307 [T] KOG3417 Ras1 guanine nucleotide exchange factor 77 2e-13
7302879 [T] KOG3417 Ras1 guanine nucleotide exchange factor 77 2e-13
7302878 [T] KOG3417 Ras1 guanine nucleotide exchange factor 77 2e-13
SPCC1442.01 [T] KOG3417 Ras1 guanine nucleotide exchange factor 73 3e-12
CE28222 [T] KOG3629 Guanine-nucleotide releasing factor 73 4e-12
Hs20127536 [T] KOG3629 Guanine-nucleotide releasing factor 72 8e-12
Hs6912456 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 71 1e-11
Hs22046650 [T] KOG3629 Guanine-nucleotide releasing factor 71 1e-11
SPBC336.03 [T] KOG3417 Ras1 guanine nucleotide exchange factor 69 5e-11
Hs20546742 [T] KOG3417 Ras1 guanine nucleotide exchange factor 69 7e-11
Hs4758532 [T] KOG3629 Guanine-nucleotide releasing factor 68 9e-11
7290754 [T] KOG3417 Ras1 guanine nucleotide exchange factor 68 9e-11
Hs4885357 [T] KOG3417 Ras1 guanine nucleotide exchange factor 67 3e-10
Hs19923151 [T] KOG3417 Ras1 guanine nucleotide exchange factor 67 3e-10
Hs7657261 [T] KOG3542 cAMP-regulated guanine nucleotide exchange... 64 2e-09
CE28081 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 64 2e-09
CE28080 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 64 2e-09
CE05713 [T] KOG3417 Ras1 guanine nucleotide exchange factor 63 4e-09
Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 62 6e-09
7302302 [T] KOG2378 cAMP-regulated guanine nucleotide exchange f... 62 6e-09
7296574 [T] KOG3541 Predicted guanine nucleotide exchange factor 60 3e-08
Hs15529996 [T] KOG3417 Ras1 guanine nucleotide exchange factor 59 4e-08
YAL024c [T] KOG3417 Ras1 guanine nucleotide exchange factor 57 2e-07
Hs7706513 [T] KOG3542 cAMP-regulated guanine nucleotide exchange... 57 2e-07
Hs20149570 [T] KOG3417 Ras1 guanine nucleotide exchange factor 57 2e-07
Hs22048159 [T] KOG3417 Ras1 guanine nucleotide exchange factor 57 3e-07
Hs7662334 [T] KOG3417 Ras1 guanine nucleotide exchange factor 56 3e-07
CE23992 [T] KOG2378 cAMP-regulated guanine nucleotide exchange f... 56 3e-07
Hs20070215 [T] KOG2378 cAMP-regulated guanine nucleotide exchang... 55 6e-07
Hs7705939 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 54 2e-06
7302774 [T] KOG3541 Predicted guanine nucleotide exchange factor 53 4e-06
7297097 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 52 5e-06
>YCR038c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 642
Score = 115 bits (287), Expect = 6e-25
Identities = 90/294 (30%), Positives = 145/294 (48%), Gaps = 62/294 (21%)
Query: 1066 LNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLS 1125
LN+S P ++K ++L+ES+++L I E ++ K+ D + ++S+ TL+N LS
Sbjct: 409 LNVS---PWSLAKTLTLLESSLYLDI---ETIEFTRHFKHNDTT----IDSVFTLSNQLS 458
Query: 1126 NYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWG 1185
+YVLE+ L ++ I WL++ALS LY RN N+LASI+T+LQ++ I RLS+
Sbjct: 459 SYVLETTL-------QQTHTISYWLQVALSCLYLRNLNSLASIITSLQNHSIERLSLPID 511
Query: 1186 MLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFL 1245
+ S+ LF+ L ++HPNNNY VYR+ I+ PF +L +
Sbjct: 512 VKSD---HLFQRLKVVVHPNNNYNVYRRTIK------------HIFHSQLPCVPFTSLLI 556
Query: 1246 QDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQVGYDLENKHNPSKKRD 1305
+D+TFI +GN F + +N+ K+ +I V+ Q+ Q + D
Sbjct: 557 RDITFIRDGNDTFT-----KDGNNVNMQKFNQITKIVAFAQYLQ----------QKQYED 601
Query: 1306 SFFSLTGTIDIDSKSIKPVAELQEFILFEFWRTNTLYVKDSDRGYTLSLEMLPR 1359
S T + IK +TLY + DR Y +S+ +PR
Sbjct: 602 IHCSNTTARSLLGAMIK---------------VHTLYNDNKDRAYQVSIAKVPR 640
>YLR310c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1589
Score = 90.1 bits (222), Expect = 2e-17
Identities = 60/231 (25%), Positives = 112/231 (47%), Gaps = 20/231 (8%)
Query: 1066 LNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLS 1125
L + +++P + Q++++E ++L+IT E L + +K ++ SPN+ I N L+
Sbjct: 1299 LKLLDIDPYTYATQLTVLEHDLYLRITMFECLDRAWGTKYCNMGGSPNITKFIANANTLT 1358
Query: 1126 NYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWG 1185
N+V +I+ +K R+ + ++ +A NF+++ +I++ L S I RL W
Sbjct: 1359 NFVSHTIVKQA-DVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWD 1417
Query: 1186 MLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFL 1245
++S E +L + L+ ++ N+ YR+ + PFF ++L
Sbjct: 1418 LVSTESKDLLKNLNNLMDSKRNFVKYRELLR--------------SVTDVACVPFFGVYL 1463
Query: 1246 QDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTV-SMMQFFQVGYDLE 1295
DLTF GNP+F + +IN K KI N V ++ F + Y L+
Sbjct: 1464 SDLTFTFVGNPDFLH----NSTNIINFSKRTKIANIVEEIISFKRFHYKLK 1510
>Hs7662070 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 557
Score = 80.1 bits (196), Expect = 2e-14
Identities = 56/190 (29%), Positives = 92/190 (47%), Gaps = 16/190 (8%)
Query: 1067 NISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSN 1126
++ ++ P E + QI+L++ +F I P EL C +S K S +PNV + N +S
Sbjct: 45 DVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKH-SLAPNVVAFTRRFNQVSF 103
Query: 1127 YVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGM 1186
+V+ IL LK RA + +++IA L N ++L S+++ LQS I RL+ W +
Sbjct: 104 WVVREILTAQT-LKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWAL 162
Query: 1187 LSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQ 1246
L+ +D FE L ++ +NYK R+ I P+ ++L
Sbjct: 163 LNRKDKTTFEKLDYLMSKEDNYKRTREYIR--------------SLKMVPSIPYLGIYLL 208
Query: 1247 DLTFIDEGNP 1256
DL +ID P
Sbjct: 209 DLIYIDSAYP 218
>7294445 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 980
Score = 80.1 bits (196), Expect = 2e-14
Identities = 61/235 (25%), Positives = 109/235 (45%), Gaps = 23/235 (9%)
Query: 1077 SKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLESILMPG 1136
++Q++ +++ +F ++ P + L ++ + D S V + I N + V+ SIL+
Sbjct: 487 AEQLTRMDTELFKRLIPHQCLGHTWARR--DSGGSETVVATINQFNAVLFRVVSSILIDR 544
Query: 1137 IPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNEDVELFE 1196
+ ++RAL I W+ IA +NF++L +I++ L S I RLS +W +L E +E+F
Sbjct: 545 LKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFT 604
Query: 1197 YLSKIIHPNNNYKVYRKKIEKXXXX-------------XXXXXXXXXXXXXXXXXPFFNL 1243
L+ I +NN R+ +++ P+
Sbjct: 605 ELANICSEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGT 664
Query: 1244 FLQDLTFIDEGNPNFKNPDSFRPNKLINID---KYFKIMNTVSMMQFFQVGYDLE 1295
FL DLT I + NPD NKLIN D K F+++ + ++Q Y+L+
Sbjct: 665 FLTDLTMI-----HTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQ 714
>Hs8922307 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 279
Score = 76.6 bits (187), Expect = 2e-13
Identities = 54/191 (28%), Positives = 90/191 (46%), Gaps = 16/191 (8%)
Query: 1067 NISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSN 1126
++ ++ P E + QI+L++ +F I P EL C ++ K S +PN + N +S
Sbjct: 44 DVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEK-YSSAPNAVAFTRRFNHVSF 102
Query: 1127 YVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGM 1186
+V+ IL LK RA + +++ A N +AL ++++ LQS I RL+ W +
Sbjct: 103 WVVREILHAQT-LKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWAL 161
Query: 1187 LSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQ 1246
LS +D FE L ++ +NYK R I P+ ++L
Sbjct: 162 LSRKDKTTFEKLEYVMSKEDNYKRLRDYI--------------SSLKMTPCIPYLGIYLS 207
Query: 1247 DLTFIDEGNPN 1257
DLT+ID P+
Sbjct: 208 DLTYIDSAYPS 218
>7302879 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 702
Score = 76.6 bits (187), Expect = 2e-13
Identities = 69/257 (26%), Positives = 117/257 (44%), Gaps = 29/257 (11%)
Query: 1052 SKNQAPPRNLIHNDLNISELNPLEV-----SKQISLIESTIFLKITPPELLKCKYSSKNP 1106
SK+Q+ P + L+ L+ L V + QI+L++ +F +I P EL C ++ K+
Sbjct: 141 SKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDK 200
Query: 1107 DLSKSPNVNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALA 1166
++ +PN+ + N S + ++ IL P K+RA I ++++A N ++L
Sbjct: 201 HVN-TPNIVAFTKRFNHTSFWTVQEILNAEQP-KQRAEIITHFIKVAKKLHELNNLHSLF 258
Query: 1167 SIMTTLQSYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXX 1226
+I++ +QS I RL+ W LS +D F+ LS I +N+ R +E
Sbjct: 259 AIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLE---------- 308
Query: 1227 XXXXXXXXXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQ 1286
P+ LFL DL +ID +P + P + N K I+ +S Q
Sbjct: 309 -----SLRLPCIPYLGLFLTDLIYIDLAHP---HKGGLEPEQRRN--KMNNILRVISNYQ 358
Query: 1287 FFQVGYDLENKHNPSKK 1303
Q Y KH ++K
Sbjct: 359 --QSNYKHLQKHEATQK 373
>7302878 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 665
Score = 76.6 bits (187), Expect = 2e-13
Identities = 69/257 (26%), Positives = 117/257 (44%), Gaps = 29/257 (11%)
Query: 1052 SKNQAPPRNLIHNDLNISELNPLEV-----SKQISLIESTIFLKITPPELLKCKYSSKNP 1106
SK+Q+ P + L+ L+ L V + QI+L++ +F +I P EL C ++ K+
Sbjct: 141 SKSQSLPAHASIKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKKDK 200
Query: 1107 DLSKSPNVNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALA 1166
++ +PN+ + N S + ++ IL P K+RA I ++++A N ++L
Sbjct: 201 HVN-TPNIVAFTKRFNHTSFWTVQEILNAEQP-KQRAEIITHFIKVAKKLHELNNLHSLF 258
Query: 1167 SIMTTLQSYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXX 1226
+I++ +QS I RL+ W LS +D F+ LS I +N+ R +E
Sbjct: 259 AIISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLE---------- 308
Query: 1227 XXXXXXXXXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQ 1286
P+ LFL DL +ID +P + P + N K I+ +S Q
Sbjct: 309 -----SLRLPCIPYLGLFLTDLIYIDLAHP---HKGGLEPEQRRN--KMNNILRVISNYQ 358
Query: 1287 FFQVGYDLENKHNPSKK 1303
Q Y KH ++K
Sbjct: 359 --QSNYKHLQKHEATQK 373
>SPCC1442.01 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 911
Score = 73.2 bits (178), Expect = 3e-12
Identities = 64/237 (27%), Positives = 108/237 (45%), Gaps = 28/237 (11%)
Query: 1058 PRNLIHNDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSI 1117
P +I+ D + L P E++KQ+ ++E F I+ + L + + N K S
Sbjct: 649 PDPIIYKDELVLLLPPREIAKQLCILEFQSFSHISRIQFLTKIWDNLNRFSPKEKT--ST 706
Query: 1118 ITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVI 1177
L+N L N+V E+I+ P ++R + ++++ NF +L SI++ L S I
Sbjct: 707 FYLSNHLVNFVTETIVQEEEP-RRRTNVLAYFIQVCDYLRELNNFASLFSIISALNSSPI 765
Query: 1178 SRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXX 1237
RL W L+++ + FE L+ + N+ YR +E
Sbjct: 766 HRLRKTWANLNSKTLASFELLNNLTEARKNFSNYRDCLENCVLPCV-------------- 811
Query: 1238 XPFFNLFLQDLTFIDEGN-PNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ-VGY 1292
PF ++ DLTF+ GN NF+N +IN DK K+ ++ ++ FQ VGY
Sbjct: 812 -PFLGVYFTDLTFLKTGNKDNFQN--------MINFDKRTKVTRILNEIKKFQSVGY 859
>CE28222 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 860
Score = 72.8 bits (177), Expect = 4e-12
Identities = 52/238 (21%), Positives = 102/238 (42%), Gaps = 21/238 (8%)
Query: 1067 NISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSN 1126
++ + N +++++Q++ ++ +F ++ + C +S + + V + I N +S
Sbjct: 229 DVGKENCVQIAEQLTFWDAALFKELLIHQCQGCVWSKRRTAGERVYTVKATIEQFNSVSQ 288
Query: 1127 YVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGM 1186
V+ SI++P + RA I W+ IA +NF++L +++++LQS + RL W
Sbjct: 289 RVMTSIVLPDCRPEYRAKIISKWIDIARELRALKNFSSLKAVLSSLQSEPVHRLKSAWNS 348
Query: 1187 LSNEDVELFEYLSKIIH--PNNNYKVYRKKIEKXXXXXXX-------------XXXXXXX 1231
+ N + F LS I + + RK +E+
Sbjct: 349 VPNRSISQFRELSSIYETDEDGDQGNARKILEQEGTAKSSPLRRPQLIQNCRRTKSDVNL 408
Query: 1232 XXXXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ 1289
P+ FL DL +DE P+ + P LIN +K K ++ ++ FQ
Sbjct: 409 AECQGTVPYLGNFLTDLAMVDESTPD------YTPENLINFEKRRKEFEVLAKLRLFQ 460
>Hs20127536 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 803
Score = 71.6 bits (174), Expect = 8e-12
Identities = 57/234 (24%), Positives = 104/234 (44%), Gaps = 27/234 (11%)
Query: 1076 VSKQISLIESTIFLKITPPELLKCKYSSKNPDLSK--SPNVNSIITLTNLLSNYVLESIL 1133
V++Q++ +++ +F K+ P L C +S ++ +K +P + + I+ N L+ V+ +IL
Sbjct: 271 VAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTIL 330
Query: 1134 MPGIPLK--KRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNED 1191
G LK +RA I+ W+ IA +NF++L +I++ LQS I RL W + +
Sbjct: 331 -GGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDR 389
Query: 1192 VELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXX----------------XXXXXX 1235
+ +FE LS I +NN+ R+ + K
Sbjct: 390 MLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQ 449
Query: 1236 XXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ 1289
P+ FL DLT +D ++ LIN +K + ++ ++ Q
Sbjct: 450 GTVPYLGTFLTDLTMLDTALQDYIE------GGLINFEKRRREFEVIAQIKLLQ 497
>Hs6912456 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 580
Score = 71.2 bits (173), Expect = 1e-11
Identities = 112/533 (21%), Positives = 206/533 (38%), Gaps = 71/533 (13%)
Query: 769 DKMKDEIVFDKNENLAGISFRALVFMITD-----EMRKSDDNLLYTFLLNYKSFGNSEEL 823
D D ++ D+ ++G + L ++ D K + LL FLL Y F +++L
Sbjct: 59 DDSVDSLLSDRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDL 118
Query: 824 IELLISRFDSKSQAIKYTFGGKNGTFXXXXXXXXXXXXXXCKVIQLWMESFWDYGDDYKL 883
+ L+ + +K KY +N + + W+ D++
Sbjct: 119 CQALLRHYSAK----KYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLPE-----DEHSK 169
Query: 884 IALLINFFN--EEVTEHLPIEAKLLIEIAAKLYTYSPKRLHKNPDPYIQLIPRNVNPVKK 941
+ L + N ++V E+ PI K L E L + R H D Y +P KK
Sbjct: 170 MFLKTIYRNVLDDVYEY-PILEKELKEFQKILGMH---RRH-TVDEY--------SPQKK 216
Query: 942 TNSGLXXXXXXXXXXXXXXXXXXFDEKFIEKYELTKLPLSSHSTISLPVPILSLGNSSLL 1001
+ +E F Y ++ HS +S+ + S+ L
Sbjct: 217 NKALFHQFSLKENWLQHRGTVTETEEIFCHVY------ITEHSYVSVKAKVSSIAQEILK 270
Query: 1002 TKRNM-----SDIERIVLTYRDMVGFPNGAITTRNFVTNYSLE--NLISEWMKLVSNSKN 1054
D+ + +T+ + + V + SLE I + K ++++ N
Sbjct: 271 VVAEKIQYAEEDLALVAITFSG----EKHELQPNDLVISKSLEASGRIYVYRKDLADTLN 326
Query: 1055 Q-APPRNLIHNDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPN 1113
A + I +N +++ ++ + ++F I EL+ +S + + N
Sbjct: 327 PFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSG-EHTAN 385
Query: 1114 VNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQ 1173
++ ++ N + +V IL+ L KR +K +++IA RN N+ +I+ L
Sbjct: 386 LSLLLQRCNEVQLWVATEILLCS-QLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLN 444
Query: 1174 SYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXX 1233
+ +SRLS W + + +LF L + P+ N+K YR +K
Sbjct: 445 TASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKK---------------M 489
Query: 1234 XXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQ 1286
PF L L+D+TFI EGN F + L+N +K I +TV ++
Sbjct: 490 KPPKIPFMPLLLKDVTFIHEGNKTFL-------DNLVNFEKLHMIADTVRTLR 535
>Hs22046650 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 1067
Score = 70.9 bits (172), Expect = 1e-11
Identities = 51/226 (22%), Positives = 99/226 (43%), Gaps = 18/226 (7%)
Query: 1076 VSKQISLIESTIFLKITPPELLKCKYSSKNPDLSK--SPNVNSIITLTNLLSNYVLESIL 1133
V++Q +L+++ +F K+ P L +S ++ + +P + + +T N ++N V+ + L
Sbjct: 520 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 579
Query: 1134 -MPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNEDV 1192
RA ++ W+ +A +NF++L +I++ LQS I RL W +S +
Sbjct: 580 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 639
Query: 1193 ELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXX---------XXXXXXXXXXPFFNL 1243
+F+ LS+I NNY + R+ + K P+
Sbjct: 640 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 699
Query: 1244 FLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ 1289
FL DL +D ++ +LIN +K K ++ ++ Q
Sbjct: 700 FLTDLVMLDTAMKDYLY------GRLINFEKRRKEFEVIAQIKLLQ 739
>SPBC336.03 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 987
Score = 68.9 bits (167), Expect = 5e-11
Identities = 58/232 (25%), Positives = 106/232 (45%), Gaps = 25/232 (10%)
Query: 1066 LNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLS 1125
LN+ P E + Q++L+E +I E + + S++ S+S V + I +N +
Sbjct: 746 LNVYAYTPEEFASQMTLLEFDYLKQIPSREWIFRSWVSRD---SRSA-VRNYINFSNCFT 801
Query: 1126 NYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWG 1185
+++ IL K R I +++ A L +NF+ L SI++ L S I RL +
Sbjct: 802 YWIINCILEKK-NTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIYRLHAAYK 860
Query: 1186 MLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFL 1245
++ ED+ L +I+ N+ YR + K PF + L
Sbjct: 861 LVKAEDIICLSGLREIVETKKNFSTYRALLRK---------------AELPCVPFLGVIL 905
Query: 1246 QDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVS-MMQFFQVGYDLEN 1296
DLTFIDEGNP+ + L++ +K ++ + V+ + +F Y++++
Sbjct: 906 SDLTFIDEGNPDVLDSSP----HLLSFNKRHRLADVVADVCRFQSSSYEMQS 953
>Hs20546742 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1237
Score = 68.6 bits (166), Expect = 7e-11
Identities = 55/228 (24%), Positives = 97/228 (42%), Gaps = 24/228 (10%)
Query: 1071 LNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLE 1130
L+ +E+++QI+L++ IF I E L + + + ++P + N +SN V
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKN-ERTPYIMKTSQHFNDMSNLVAS 1059
Query: 1131 SILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNE 1190
I M + RA I+ W+ +A N+N + I + L I RL W +S +
Sbjct: 1060 QI-MNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQ 1118
Query: 1191 DVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDLTF 1250
L + L K + +K R+ ++ P+ ++L DL F
Sbjct: 1119 TKALMDKLQKTVSSEGRFKNLRETLKN---------------CNPPAVPYLGMYLTDLAF 1163
Query: 1251 IDEGNPNFKNPDSFRPNKLINIDKYFKIMNTV-SMMQFFQVGYDLENK 1297
I+EG PNF L+N K I + + + QF Q Y ++++
Sbjct: 1164 IEEGTPNFTE------EGLVNFSKMRMISHIIREIRQFQQTSYRIDHQ 1205
>Hs4758532 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 777
Score = 68.2 bits (165), Expect = 9e-11
Identities = 58/247 (23%), Positives = 114/247 (45%), Gaps = 29/247 (11%)
Query: 1076 VSKQISLIESTIFLKITPPELLKCKYSSKN-PDLSK-SPNVNSIITLTNLLSNYVLESIL 1133
+++Q++L+++ +FL + P + L + ++ P S P+V + +T N ++ V+ S+L
Sbjct: 247 LAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVL 306
Query: 1134 M-------PGI----PLK--KRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRL 1180
PG PL+ +RA ++ W+R+A RNF+++ ++++ LQS I RL
Sbjct: 307 GATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRL 366
Query: 1181 SMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXX-----XXXXXXXXXXXX 1235
WG + + + +F L +I +NY R+ + +
Sbjct: 367 RAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGG 426
Query: 1236 XXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINID---KYFKIMNTVSMMQFFQVGY 1292
P+ FL+DL +D + + N IN D K F +++ + +Q GY
Sbjct: 427 GVVPYLGTFLKDLVMLDAASKDELE------NGYINFDKRRKEFAVLSELRRLQNECRGY 480
Query: 1293 DLENKHN 1299
+L+ H+
Sbjct: 481 NLQPDHD 487
>7290754 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1380
Score = 68.2 bits (165), Expect = 9e-11
Identities = 63/263 (23%), Positives = 119/263 (44%), Gaps = 33/263 (12%)
Query: 1064 NDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNL 1123
N ++ +L LE+++Q++L+++ +F KI PE+L +K+ KSPN+N N
Sbjct: 1140 NQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVL---LFAKDQCEEKSPNLNKFTEHFNK 1196
Query: 1124 LSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSML 1183
+S + IL K+R + +++I N+N+ ++++ L S I RL
Sbjct: 1197 MSYWARSKILRLQ-DAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE-- 1253
Query: 1184 WGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNL 1243
W E+V F +I +++++ YR+ + + P+ L
Sbjct: 1254 WQKGITEEVRSF---CALIDSSSSFRAYRQALAE---------------TNPPCIPYIGL 1295
Query: 1244 FLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTV-SMMQFFQVGYDLENKHNPSK 1302
LQDLTF+ GN ++ + +IN K ++ N + +M +F + Y +
Sbjct: 1296 ILQDLTFVHVGNQDYLS------KGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIR 1349
Query: 1303 KRDSFFSLTGTIDI--DSKSIKP 1323
D+F G ++ S+ IKP
Sbjct: 1350 FFDNFKDFMGEEEMWQISEKIKP 1372
>Hs4885357 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1077
Score = 66.6 bits (161), Expect = 3e-10
Identities = 63/272 (23%), Positives = 122/272 (44%), Gaps = 32/272 (11%)
Query: 1024 NGAITTRNFVTNYSLENLISEWMKLVSNSKNQAPPRNLIHNDLNISELNPLEVSKQISLI 1083
NG ++ + L+ + + + + S R + + + + E+++Q++L+
Sbjct: 792 NGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLL 851
Query: 1084 ESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLESILMPGIPLKKRA 1143
++ +F KI PE+L +K + KSPN+ N +S Y + SI+M + R
Sbjct: 852 DAELFYKIEIPEVLLW---AKEQNEEKSPNLTQFTEHFNNMS-YWVRSIIMLQEKAQDRE 907
Query: 1144 LRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNEDVELFEYLSKIIH 1203
+ +++I NFN+ +I++ L S I RL W ++E L EY + +I
Sbjct: 908 RLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQKQTSEG--LAEYCT-LID 962
Query: 1204 PNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDLTFIDEGNPNFKNPDS 1263
+++++ YR + + P+ L LQDLTF+ GNP++ +
Sbjct: 963 SSSSFRAYRAALSEVEPPCI---------------PYLGLILQDLTFVHLGNPDYIDGK- 1006
Query: 1264 FRPNKLINIDKYFKIMNTVSMMQFF-QVGYDL 1294
+N K ++ N + M+ F Q YD+
Sbjct: 1007 ------VNFSKRWQQFNILDSMRCFQQAHYDM 1032
>Hs19923151 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1275
Score = 66.6 bits (161), Expect = 3e-10
Identities = 50/230 (21%), Positives = 103/230 (44%), Gaps = 34/230 (14%)
Query: 1074 LEVSKQISLIESTIFLKITPPEL-----LKCKYSSKNPDLSKSPNVNSIITLTNLLSNYV 1128
LE+++Q++L++ +F KI E +K + + + P + K+ ++NL+++ +
Sbjct: 1042 LEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKT--TKHFNDISNLIASEI 1099
Query: 1129 LESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLS 1188
+ + + R I+ W+ +A N+NA+ I +++ I RL W +S
Sbjct: 1100 IRNE-----DINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVS 1154
Query: 1189 NEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDL 1248
+ L + L K++ +K R+ ++ P+ ++L DL
Sbjct: 1155 KQTKALIDKLQKLVSSEGRFKNLREALKN---------------CDPPCVPYLGMYLTDL 1199
Query: 1249 TFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTV-SMMQFFQVGYDLENK 1297
FI+EG PN+ + L+N K I + + + QF Q Y +E++
Sbjct: 1200 AFIEEGTPNYTE------DGLVNFSKMRMISHIIREIRQFQQTAYKIEHQ 1243
>Hs7657261 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1499
Score = 63.9 bits (154), Expect = 2e-09
Identities = 51/214 (23%), Positives = 98/214 (44%), Gaps = 23/214 (10%)
Query: 1061 LIHNDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITL 1120
L + +++ +L+ +EV+ Q+S+ +F I P E + + ++ + N+ +
Sbjct: 706 LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSK--TSCANLKRFEEV 763
Query: 1121 TNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRL 1180
N + +V IL LK+ + IK +++IAL +NFN++ +I++ L ++RL
Sbjct: 764 INQETFWVASEILRETNQLKRMKI-IKHFIKIALHCRECKNFNSMFAIISGLNLAPVARL 822
Query: 1181 SMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPF 1240
W L N+ +LF+ L + P+ N YR + P
Sbjct: 823 RTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLN-------------SQNLQPPIIPL 869
Query: 1241 FNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDK 1274
F + +DLTF+ EGN + + + L+N +K
Sbjct: 870 FPVIKKDLTFLHEGNDS-------KVDGLVNFEK 896
>CE28081 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1311
Score = 63.5 bits (153), Expect = 2e-09
Identities = 55/242 (22%), Positives = 104/242 (42%), Gaps = 24/242 (9%)
Query: 1054 NQAPPRNLIHNDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPN 1113
++ P L + LN V+ Q++L + ++F I P E L + K SP
Sbjct: 876 DELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLF--KLDSKYGSPK 933
Query: 1114 VNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQ 1173
+ L N +V I ++KRA IK ++++A RNFN++ +IM+ L
Sbjct: 934 LEEFEQLFNREMWWVATEICTER-HVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLD 992
Query: 1174 SYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXX 1233
+ RL W +S++ + + + + +++ P+ N YR+ + +
Sbjct: 993 KPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAE-------------VAQ 1039
Query: 1234 XXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTV-SMMQFFQVGY 1292
P + + +DLTF +GN + KLIN +K I ++ +M+ Y
Sbjct: 1040 EPPVVPIYPVIKKDLTFAHDGNATYS-------EKLINFEKLRLIAKSIRGVMKLSSAPY 1092
Query: 1293 DL 1294
++
Sbjct: 1093 EI 1094
>CE28080 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1470
Score = 63.5 bits (153), Expect = 2e-09
Identities = 55/242 (22%), Positives = 104/242 (42%), Gaps = 24/242 (9%)
Query: 1054 NQAPPRNLIHNDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPN 1113
++ P L + LN V+ Q++L + ++F I P E L + K SP
Sbjct: 876 DELAPELLKEAQTQLLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLF--KLDSKYGSPK 933
Query: 1114 VNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQ 1173
+ L N +V I ++KRA IK ++++A RNFN++ +IM+ L
Sbjct: 934 LEEFEQLFNREMWWVATEICTER-HVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLD 992
Query: 1174 SYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXX 1233
+ RL W +S++ + + + + +++ P+ N YR+ + +
Sbjct: 993 KPAVRRLHSSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAE-------------VAQ 1039
Query: 1234 XXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTV-SMMQFFQVGY 1292
P + + +DLTF +GN + KLIN +K I ++ +M+ Y
Sbjct: 1040 EPPVVPIYPVIKKDLTFAHDGNATYS-------EKLINFEKLRLIAKSIRGVMKLSSAPY 1092
Query: 1293 DL 1294
++
Sbjct: 1093 EI 1094
>CE05713 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 638
Score = 62.8 bits (151), Expect = 4e-09
Identities = 59/251 (23%), Positives = 109/251 (42%), Gaps = 28/251 (11%)
Query: 1066 LNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLS 1125
L+ + +P ++S +S I+ + +I+ EL K K+ L P + I++ N LS
Sbjct: 176 LSFVQASPSDISTSLSHIDYRVLSRISITEL---KQYVKDGHLRSCPMLERSISVFNNLS 232
Query: 1126 NYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWG 1185
N+V IL P K+RA + ++ +A NFN L S++ + ++RL+ +
Sbjct: 233 NWVQCMILNKTTP-KERAEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVARLAKTYA 291
Query: 1186 MLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFL 1245
+LSN+ + L+ ++ +N+ YRK + P + L
Sbjct: 292 VLSNDIKKELTQLTNLLSAQHNFCEYRKAL--------------GACNKKFRIPIIGVHL 337
Query: 1246 QDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQVGYDLENKHNPSKKRD 1305
+DL I+ NF+ +KL+ + K + + F Q G++L P D
Sbjct: 338 KDLVAINCSGANFEKTKCISSDKLVKLSKLLS-----NFLVFNQKGHNL-----PEMNMD 387
Query: 1306 SFFSLTGTIDI 1316
+L ++DI
Sbjct: 388 LINTLKVSLDI 398
>Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 1011
Score = 62.0 bits (149), Expect = 6e-09
Identities = 45/215 (20%), Positives = 99/215 (45%), Gaps = 24/215 (11%)
Query: 1075 EVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLESILM 1134
+++ Q+++ + +F + EL+ + N + + N++ + N + +V+ I +
Sbjct: 775 DLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTA-NLDLFLRRFNEIQFWVVTEICL 833
Query: 1135 PGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNEDVEL 1194
L KR +K +++IA ++N N+ +I+ L + +SRL++ W L ++ +
Sbjct: 834 CS-QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNIAVSRLALTWEKLPSKFKKF 892
Query: 1195 FEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDLTFIDEG 1254
+ ++ P+ N++ YR + K PF L ++D+TF EG
Sbjct: 893 YAEFESLMDPSRNHRAYRLTVAK---------------LEPPLIPFMPLLIKDMTFTHEG 937
Query: 1255 NPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ 1289
N F + L+N +K I NT +++++
Sbjct: 938 NKTF-------IDNLVNFEKMRMIANTARTVRYYR 965
>7302302 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 957
Score = 62.0 bits (149), Expect = 6e-09
Identities = 64/296 (21%), Positives = 128/296 (42%), Gaps = 35/296 (11%)
Query: 993 LSLGNSSLLTKRNMSDIERIVLTYRDMVGFPNG-AITTRNFVTNYSLENLISEWMKLVSN 1051
L+ G L+ S+ ER V D V P G ++ R FV+ + + + ++
Sbjct: 648 LNRGPEDLVLVEVKSNGERSVFKDND-VSIPTGLSLNGRLFVS-------VKDHLDALTQ 699
Query: 1052 SKNQAPPRNLIHNDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKS 1111
+ Q P + DL I L+ E++ I+L E +F + ELL + + +
Sbjct: 700 LQEQECPTEGVDIDLEI--LSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFG-KIT 756
Query: 1112 PNVNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTT 1171
N++ + N + +++ ++ L KR ++ ++++A ++N NA +++
Sbjct: 757 ANLDVFLRRFNEVQYWIVTELVSTP-SLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMG 815
Query: 1172 LQSYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXX 1231
L + +SRL W + ++ ++F+ +I P+ N++ YR + K
Sbjct: 816 LSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGK-------------- 861
Query: 1232 XXXXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQF 1287
PF L L+D+TF EGN + L+N +K + T+ ++F
Sbjct: 862 -LQPPLIPFMPLLLKDMTFAHEGNKT-------SLDGLVNFEKMHMMAQTMRTIRF 909
>7296574 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 612
Score = 59.7 bits (143), Expect = 3e-08
Identities = 48/177 (27%), Positives = 75/177 (42%), Gaps = 16/177 (9%)
Query: 1107 DLSKSPNVNSIITLTNLLSNYVLESILMPGIPLKKRALRI-KSWLRIALSSLYFRNFNAL 1165
D+ K+ N+ S + N LS I+ P KK+ +RI + W+ A NFN+L
Sbjct: 375 DMKKTRNLESYVQWFNRLSYLTASEIVK--YPKKKQRVRIIEYWIETARECFNIGNFNSL 432
Query: 1166 ASIMTTLQSYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXX 1225
+I+ L I RL W + + F L + P +N+ YR ++
Sbjct: 433 MAIIAGLNLAPIGRLKKTWAKVQSAK---FSVLEHQMDPTSNFNSYRSTLK----AAMWR 485
Query: 1226 XXXXXXXXXXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTV 1282
PFF+LF++DL F++EG N PN IN +K ++ V
Sbjct: 486 SEGATEERERIIIPFFSLFVKDLYFLNEGCSN------RLPNNHINFEKCSQLAKQV 536
>Hs15529996 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1333
Score = 59.3 bits (142), Expect = 4e-08
Identities = 46/219 (21%), Positives = 100/219 (45%), Gaps = 22/219 (10%)
Query: 1071 LNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLE 1130
L+P+E+++Q++L+ES ++ + P EL+ ++ ++ +++ SPN+ +I T L+ + E
Sbjct: 779 LHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEIN-SPNLLKMIRHTTNLTLW-FE 836
Query: 1131 SILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNE 1190
++ L++R + + I NFN + +++ + S + RL + + +
Sbjct: 837 KCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSR 896
Query: 1191 DVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDLTF 1250
++ E ++ ++YK Y K+ PFF ++L ++
Sbjct: 897 QKKILEEAHEL--SEDHYKKYLAKLR---------------SINPPCVPFFGIYLTNILK 939
Query: 1251 IDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ 1289
+EGNP +LIN K K+ +Q +Q
Sbjct: 940 TEEGNPEVLKRHG---KELINFSKRRKVAEITGEIQQYQ 975
>YAL024c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1435
Score = 57.0 bits (136), Expect = 2e-07
Identities = 81/370 (21%), Positives = 154/370 (40%), Gaps = 59/370 (15%)
Query: 967 EKFIEKYELTKLPLS---SHSTISLPVPILSLGN------------SSLLTKRNMSDIER 1011
EK EK E TK + S ++ V +L+L N SLL +R I
Sbjct: 1069 EKIPEKPENTKSSDAIGIKTSKLADEVEMLNLNNLPSFQNSPAEKRKSLLIERRRQTIMN 1128
Query: 1012 IVLT--YRDMVGFPNGAITTRNFVTNYSLENLISEWMKLVSNSKNQAPPRNLIHNDLNIS 1069
I T + GF + + + N + ++ +L+ + + +N+ ++
Sbjct: 1129 IPFTPDQSEKEGFTSSSPEKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISNNESHVP 1188
Query: 1070 EL---NPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPD-------LSKSPNVNSI-- 1117
+ + L V++Q++LIE I +I +LL K + P L ++ ++ I
Sbjct: 1189 FILMYDSLSVAQQMTLIEKEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDL 1248
Query: 1118 -ITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYV 1176
I+ NL ++++ IL+ KR + I+ ++ +A F+NFN L I+ L S V
Sbjct: 1249 AISRFNLTVDWIISEILLTKSSKMKRNV-IQRFIHVADHCRTFQNFNTLMEIILALSSSV 1307
Query: 1177 ISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXX 1236
+ + + W ++ D+ +E L KI + NY R +
Sbjct: 1308 VQKFTDAWRLIEPGDLLTWEELKKIPSLDRNYSTIRNLLN-------------SVNPLVG 1354
Query: 1237 XXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFK----IMNTVSMMQF----- 1287
PF ++L DL + N + D +K++N +K+ + N + +Q+
Sbjct: 1355 CVPFIVVYLSDL------SANAEKKDWILEDKVVNYNKFDTNVQIVKNFIQRVQWSKFYT 1408
Query: 1288 FQVGYDLENK 1297
F+V ++L +K
Sbjct: 1409 FKVNHELLSK 1418
>Hs7706513 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1204
Score = 57.0 bits (136), Expect = 2e-07
Identities = 51/215 (23%), Positives = 96/215 (43%), Gaps = 31/215 (14%)
Query: 1064 NDLNISELNPLEVSKQISLIESTIFLKITPPE----LLKCKYSSKNPDLSKSPNVNSIIT 1119
+ L++ +L+ +EV+ Q+S+ + +F I P E L K + N L + ++
Sbjct: 902 SQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLKRFEDI----- 956
Query: 1120 LTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISR 1179
N + +V IL LK+ + IK +++IAL +NFN++ +I++ L ++R
Sbjct: 957 -VNQETFWVASEILTEANQLKRMKI-IKHFIKIALHCRECKNFNSMFAIISGLNLASVAR 1014
Query: 1180 LSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXP 1239
L W L ++ + + L I P+ N YR + P
Sbjct: 1015 LRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNIL-------------SSQSMQPPIIP 1061
Query: 1240 FFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDK 1274
F + +D+TF+ EGN + + + L+N +K
Sbjct: 1062 LFPVVKKDMTFLHEGNDS-------KVDGLVNFEK 1089
>Hs20149570 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 671
Score = 57.0 bits (136), Expect = 2e-07
Identities = 58/239 (24%), Positives = 103/239 (42%), Gaps = 27/239 (11%)
Query: 1053 KNQAPPRNLIHN-----DLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPD 1107
K Q RN + L L P+E+++ ++ +E F KI + D
Sbjct: 192 KRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTVD 251
Query: 1108 LSKSPNVNSIITLTNLLSNYVLESILM-PGIPLKKRALRIKSWLRIALSSLYFRNFNALA 1166
+P + I+L N +S +V IL P P +RAL I ++ +A L +NFN L
Sbjct: 252 ---NPVLERFISLFNSVSQWVQLMILSKPTAP--QRALVITHFVHVAEKLLQLQNFNTLM 306
Query: 1167 SIMTTLQSYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXX 1226
+++ L ISRL +S E ++L+E L++++ NY YR+++
Sbjct: 307 AVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL----------- 355
Query: 1227 XXXXXXXXXXXXPFFNLFLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMM 1285
P + L+DL + P++ +P R N + + F I+ ++M+
Sbjct: 356 ----AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNG-AKMKQLFSILEELAMV 409
>Hs22048159 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 558
Score = 56.6 bits (135), Expect = 3e-07
Identities = 46/219 (21%), Positives = 101/219 (46%), Gaps = 22/219 (10%)
Query: 1071 LNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLE 1130
L+P+E+++Q++L+ES ++ K+ P EL+ ++ ++ +++ SPN+ +I T L+ + E
Sbjct: 3 LHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEIN-SPNLLKMIRHTTNLTLW-FE 60
Query: 1131 SILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNE 1190
++ ++R + + I NFN + I++ + S + RL + L
Sbjct: 61 KCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQER 120
Query: 1191 DVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDLTF 1250
++ + ++ +++K Y K++ PFF ++L ++
Sbjct: 121 KRKILDEAVEL--SQDHFKKYLVKLK---------------SINPPCVPFFGIYLTNILK 163
Query: 1251 IDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ 1289
+EGN +F + LIN K K+ +Q +Q
Sbjct: 164 TEEGNNDFLKK---KGKDLINFSKRRKVAEITGEIQQYQ 199
>Hs7662334 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 689
Score = 56.2 bits (134), Expect = 3e-07
Identities = 45/172 (26%), Positives = 82/172 (47%), Gaps = 11/172 (6%)
Query: 1044 EWMKLVSNSKNQAPPRNLIHNDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSS 1103
+WM+ V+ K + L L P+E+++ ++ +E F +I+ + Y S
Sbjct: 127 DWMRRVTQRKKVSKKGKAC---LLFDHLEPIELAEHLTFLEHKSFRRISFTD-----YQS 178
Query: 1104 K--NPDLSKSPNVNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRN 1161
+ L +P + I L N +S +V +L P ++RA I ++ +A L +N
Sbjct: 179 YVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTP-QQRAEVITKFINVAKKLLQLKN 237
Query: 1162 FNALASIMTTLQSYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRK 1213
FN L +++ L ISRL LS+E + + +++++ N NY YRK
Sbjct: 238 FNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRK 289
>CE23992 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 1234
Score = 56.2 bits (134), Expect = 3e-07
Identities = 53/238 (22%), Positives = 99/238 (41%), Gaps = 18/238 (7%)
Query: 1023 PNGAITTRNFVTNYSLENLISEWMKLVSNSKNQAPPRNLIHNDLNISELNPLEVSKQISL 1082
PN N L + E + L+ ++Q P H+ + + ++ E++ Q+ L
Sbjct: 943 PNDRAIPTVLSLNSKLYVVNREEIPLLVPMEDQNGPTPSSHSSI-LHLIDSQELAHQLFL 1001
Query: 1083 IESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLESILMPGIPLKKR 1142
+ ELL ++ LS N++ ++ N + ++ IL+ + R
Sbjct: 1002 FHLQLLRSTDSNELLYQVIGRESFPLSMPFNLDLLVRRFNEVQHWSTTEILLA--TEENR 1059
Query: 1143 ALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNEDVELFEYLSKII 1202
+K ++ IA + +R+ + +I L ISRL++ W L ++ F L ++
Sbjct: 1060 MEILKKFISIATIAREYRDLLTVFAITLGLSHTSISRLTLTWSKLPPASLKTFSELENLL 1119
Query: 1203 HPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDLTFIDEGNPNFKN 1260
P N+++YR + K PF L L+DL FI +GN +F N
Sbjct: 1120 DPTRNHRMYRLLVSK---------------MSSPYIPFVPLILKDLMFIHQGNKSFYN 1162
>Hs20070215 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 881
Score = 55.5 bits (132), Expect = 6e-07
Identities = 50/226 (22%), Positives = 97/226 (42%), Gaps = 30/226 (13%)
Query: 1075 EVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLLSNYVLESILM 1134
+++ Q++ + ++F I EL+ ++ + N+ + N L +V + +
Sbjct: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682
Query: 1135 PGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLWGMLSNEDVEL 1194
+P RA ++ ++++A +N N+ ++M L + ISRL+ W L ++ +L
Sbjct: 683 CPVP-GPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKL 741
Query: 1195 FEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLFLQDLTFIDEG 1254
+ L +++ P+ N++VYR + K PF L L+D+TFI EG
Sbjct: 742 YSALERLLDPSWNHRVYRLALAK---------------LSPPVIPFMPLLLKDMTFIHEG 786
Query: 1255 NPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQVGYDLENKHNP 1300
N LIN +K + M+ + HNP
Sbjct: 787 NHTL-------VENLINFEKMRMMARAARMLHHCR-------SHNP 818
>Hs7705939 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 456
Score = 53.5 bits (127), Expect = 2e-06
Identities = 46/225 (20%), Positives = 96/225 (42%), Gaps = 24/225 (10%)
Query: 1065 DLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNLL 1124
D I + P +V+ ++ +F + E + + + ++ N+ ++ + +
Sbjct: 211 DTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGER-GRRETANLELLLQRCSEV 269
Query: 1125 SNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSMLW 1184
+++V +L+ P KRA +K +++IA ++ + +++ L + +SRL + W
Sbjct: 270 THWVATEVLLCEAP-GKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTW 328
Query: 1185 GMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNLF 1244
L + LF + P N+K YR+ I K PF L
Sbjct: 329 EKLPGKFKNLFRKFENLTDPCRNHKSYREVISK---------------MKPPVIPFVPLI 373
Query: 1245 LQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMMQFFQ 1289
L+DLTF+ EG+ + L+NI+K + V ++ ++
Sbjct: 374 LKDLTFLHEGSKTL-------VDGLVNIEKLHSVAEKVRTIRKYR 411
>7302774 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 704
Score = 52.8 bits (125), Expect = 4e-06
Identities = 41/142 (28%), Positives = 61/142 (42%), Gaps = 7/142 (4%)
Query: 1114 VNSIITLTNLLSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQ 1173
++S + N LS IL G +RA I W+ AL NFN+L +I+T L
Sbjct: 485 IDSYVQWFNQLSYLTATEILKLG-KKSQRAQMIDFWVETALECFNTGNFNSLMAILTALN 543
Query: 1174 SYVISRLSMLWGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXX 1233
I+RL W + FE L + P++N+ YR ++
Sbjct: 544 LTAIARLKKTWAKVQTTK---FEGLEHQMDPSSNFLNYRSTMK---AAVWRSEREMANEI 597
Query: 1234 XXXXXPFFNLFLQDLTFIDEGN 1255
PFF+LFL+DL I+E +
Sbjct: 598 ERAIIPFFSLFLKDLHAINESH 619
>7297097 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1551
Score = 52.4 bits (124), Expect = 5e-06
Identities = 49/222 (22%), Positives = 96/222 (43%), Gaps = 22/222 (9%)
Query: 1064 NDLNISELNPLEVSKQISLIESTIFLKITPPELLKCKYSSKNPDLSKSPNVNSIITLTNL 1123
++++ LN E++ Q++L + F +I E + + ++ P ++ L N
Sbjct: 860 SNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSR--YGVPMLSKFAELVNR 917
Query: 1124 LSNYVLESILMPGIPLKKRALRIKSWLRIALSSLYFRNFNALASIMTTLQSYVISRLSML 1183
+V+ I +++ + +K +++IA RNFN++ +I++ L +SRL
Sbjct: 918 EMFWVVSEICAEHNIVRRMKI-VKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQT 976
Query: 1184 WGMLSNEDVELFEYLSKIIHPNNNYKVYRKKIEKXXXXXXXXXXXXXXXXXXXXXPFFNL 1243
W L ++ LF L ++ P+ N YR+ + PF+ +
Sbjct: 977 WEKLPSKYQRLFNDLQDLMDPSRNMSKYRQLV------------SAELLAQHPIIPFYPI 1024
Query: 1244 FLQDLTFIDEGNPNFKNPDSFRPNKLINIDKYFKIMNTVSMM 1285
+DLTFI GN R + LIN +K + V ++
Sbjct: 1025 VKKDLTFIHLGNDT-------RVDGLINFEKLRMLAKEVRLL 1059
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,103,582
Number of Sequences: 60738
Number of extensions: 3130558
Number of successful extensions: 8065
Number of sequences better than 1.0e-05: 36
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 8008
Number of HSP's gapped (non-prelim): 54
length of query: 1360
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1241
effective length of database: 23,161,394
effective search space: 28743289954
effective search space used: 28743289954
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)