ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1021 good FE KOG1448 Amino acid transport and metabolism Ribose-phosphate pyrophosphokinase
r_klactIII1021 good FE KOG1448 Nucleotide transport and metabolism Ribose-phosphate pyrophosphokinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1021 357026 358429 468
(468 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOL061w [FE] KOG1448 Ribose-phosphate pyrophosphokinase 620 e-177
SPBC3D6.06c [FE] KOG1448 Ribose-phosphate pyrophosphokinase 254 1e-67
Hs20539448 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 221 2e-57
Hs4506129 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 218 2e-56
Hs4506127 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 216 8e-56
7294894 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 214 3e-55
7294893 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 214 3e-55
CE29454 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 211 1e-54
CE27199 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 211 1e-54
CE00745 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 211 1e-54
YHL011c [FE] KOG1448 Ribose-phosphate pyrophosphokinase 209 9e-54
SPCC1620.06c [FE] KOG1448 Ribose-phosphate pyrophosphokinase 204 2e-52
YBL068w [FE] KOG1448 Ribose-phosphate pyrophosphokinase 202 1e-51
YER099c [FE] KOG1448 Ribose-phosphate pyrophosphokinase 194 2e-49
Hs4506133 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-as... 174 2e-43
7301964 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-asso... 174 2e-43
Hs4506131 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-as... 172 1e-42
At1g32380 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 147 3e-35
At2g35390 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 147 4e-35
CE03789 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-asso... 144 3e-34
At2g44530 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 142 1e-33
SPAC4A8.14 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 110 6e-24
YKL181w [FE] KOG1448 Ribose-phosphate pyrophosphokinase 108 2e-23
Hs20542182 [FE] KOG1448 Ribose-phosphate pyrophosphokinase 52 2e-06
>YOL061w [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 496
Score = 620 bits (1598), Expect = e-177
Identities = 321/504 (63%), Positives = 378/504 (74%), Gaps = 46/504 (9%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M+NIVVF G SH +LV KICENL I S+V+LGKFSNGET+I++ ESVREKDVY+IQSGC
Sbjct: 3 MSNIVVFGGDSHPELVTKICENLDIHPSKVELGKFSNGETNIALRESVREKDVYIIQSGC 62
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQPDIPYTAKGAPLISKPKEKYTFE 120
G VND FM+LLILI+ACK+A ASRVTAVMPY YSRQPDIPYTAKGAP+ISKPKE YTFE
Sbjct: 63 GQVNDTFMQLLILISACKSASASRVTAVMPYLCYSRQPDIPYTAKGAPIISKPKENYTFE 122
Query: 121 SHPGTPIPQSMLTVEKPMSPNXXXXXXXXXXXXXXXXXXXXXXXXRPVELRPTSSTS--- 177
SHPGTP+ S++T ++P + + +P+ +S+T+
Sbjct: 123 SHPGTPVSSSLMT-QRPGAESSLKSLDSAIRSTINLENP------QPIRTPNSSATANNN 175
Query: 178 ---------SRIPMIPNGKAEHPSEQEQDSNADALFNASNSSYKLWVAQAGTLIANLLTT 228
SRIPMIP GK ++ S ++A LFNA N+ YKLWV QAGTLIA+LL+
Sbjct: 176 FDIKKTLSFSRIPMIPGGKLQNTSNS---TDAGELFNAQNAGYKLWVVQAGTLIAHLLSA 232
Query: 229 SGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSPDAGGAKRA 288
+GADHVITMDLHD QF GFFDIPVDNLYCKPI Q YIQH IP+YQD V+VSPDAGGAKRA
Sbjct: 233 AGADHVITMDLHDPQFPGFFDIPVDNLYCKPIAQNYIQHRIPDYQDAVIVSPDAGGAKRA 292
Query: 289 AKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESL------------ 336
IAD LELSFA+IHKERRSQLLKGPP ATLTSGG +PVS +PL+ +L
Sbjct: 293 TAIADALELSFALIHKERRSQLLKGPPDATLTSGGSLPVSPRPLVTTLVSSQNTTSSGAT 352
Query: 337 ------------DIRTSLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKL 384
TS ++ ++K+V TTMLVGDVRNK CIIVDDLVDTSYTITRAAKL
Sbjct: 353 GVAALEMKKTTSTSSTSSQSSNSSKFVQTTMLVGDVRNKVCIIVDDLVDTSYTITRAAKL 412
Query: 385 LKDQGATKIYALITHGIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVS 444
LKDQG+TK+YALITHG+FSGDAL RIGQS IDK+I++N++PQD T++ LG DRV+V+DVS
Sbjct: 413 LKDQGSTKVYALITHGVFSGDALERIGQSSIDKLIISNTVPQDRTLQYLGKDRVDVIDVS 472
Query: 445 NIFAEAIRRIHNGESISILFEHGW 468
I EAIRRIHNGESIS+LFEHGW
Sbjct: 473 CIIGEAIRRIHNGESISMLFEHGW 496
>SPBC3D6.06c [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 341
Score = 254 bits (650), Expect = 1e-67
Identities = 134/258 (51%), Positives = 173/258 (66%), Gaps = 44/258 (17%)
Query: 209 SSYKLWVAQAGTLIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHH 268
+ Y W+AQ+GTL+A+LL SGADH+ITMDLHD QFQGFFDIPVDNL+ +P+ + YI +
Sbjct: 123 TGYHPWIAQSGTLVADLLMCSGADHIITMDLHDPQFQGFFDIPVDNLFGRPLLKHYISLN 182
Query: 269 IPNYQDCVVVSPDAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVS 328
IPNY + V+VSPDAGGAKRA IAD L L FA+IHK RR
Sbjct: 183 IPNYHNAVIVSPDAGGAKRATAIADALGLDFALIHKNRR--------------------- 221
Query: 329 TKPLIESLDIRTSLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQ 388
++Y + MLVGDV+NK I++DDL+DT+YT+ RAA+ +K+
Sbjct: 222 -------------------HEYGTSLMLVGDVQNKVAILIDDLIDTAYTLVRAAEFVKEH 262
Query: 389 GATKIYALITHGIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFA 448
GA+KIYAL+TH + SGDA+ R+ S IDK+IVTN+ PQ TI G +++DV+ FA
Sbjct: 263 GASKIYALVTHCVLSGDAIERVKLSCIDKLIVTNTAPQ--TITPSGC--FDIIDVAPTFA 318
Query: 449 EAIRRIHNGESISILFEH 466
EAIRRIHNGESISIL++H
Sbjct: 319 EAIRRIHNGESISILYDH 336
Score = 125 bits (315), Expect = 1e-28
Identities = 61/109 (55%), Positives = 79/109 (71%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M N+VVF SH L ICE+L ++ +V+L KFSNGETS+ I++SVR DVY++
Sbjct: 1 MKNLVVFGTESHPKLTESICEHLCLDIGRVELSKFSNGETSVRIKQSVRGCDVYIVSPAS 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQPDIPYTAKGAPL 109
G VND+ MELLI+I+ACKTA A +VTAV+P F YSRQPD ++ GAPL
Sbjct: 61 GQVNDHLMELLIMISACKTASAKKVTAVLPVFPYSRQPDQKFSFSGAPL 109
>Hs20539448 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 318
Score = 221 bits (562), Expect = 2e-57
Identities = 114/246 (46%), Positives = 154/246 (62%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P +I+ +IP +++C++VSP
Sbjct: 111 LVANMLSIAGADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSP 170
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKER+
Sbjct: 171 DAGGAKRVTSIADQLNVDFALIHKERKKA------------------------------- 199
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V+ +LVGDV ++ I+VDD+ DT TI AA L GAT++YA++THG
Sbjct: 200 --------NEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAGATRVYAILTHG 251
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG A++RI + + ++VTN+IPQDE +K ++ V+D+S I AEAIRR HNGES+
Sbjct: 252 IFSGPAISRINTACFEAVVVTNTIPQDEKMK--HCSKIRVIDISMILAEAIRRTHNGESV 309
Query: 461 SILFEH 466
S LF H
Sbjct: 310 SYLFSH 315
Score = 124 bits (312), Expect = 2e-28
Identities = 60/97 (61%), Positives = 75/97 (76%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M NI +F+GSSH DL KI + LG+E +V KFSN ET + I+ESVR +DVY++QSGC
Sbjct: 1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGC 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G +ND+ MELLI+INACK A ASRVTAV+P F Y+RQ
Sbjct: 61 GEINDSLMELLIMINACKIASASRVTAVIPCFPYARQ 97
>Hs4506129 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 318
Score = 218 bits (555), Expect = 2e-56
Identities = 112/246 (45%), Positives = 155/246 (62%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P +I+ +I +++C++VSP
Sbjct: 111 LVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSP 170
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKER+
Sbjct: 171 DAGGAKRVTSIADRLNVEFALIHKERKKA------------------------------- 199
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V+ +LVGDV+++ I+VDD+ DT TI AA L GATK+YA++THG
Sbjct: 200 --------NEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHG 251
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG A++RI + + ++VTN+IPQ++ +K +++V+D+S I AEAIRR HNGES+
Sbjct: 252 IFSGPAISRINNAAFEAVVVTNTIPQEDKMK--HCTKIQVIDISMILAEAIRRTHNGESV 309
Query: 461 SILFEH 466
S LF H
Sbjct: 310 SYLFSH 315
Score = 126 bits (316), Expect = 8e-29
Identities = 61/97 (62%), Positives = 76/97 (77%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M NIV+F+GSSH DL ++ + LG+E +V KFSN ETS+ I ESVR +DVY+IQSGC
Sbjct: 1 MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGC 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G +NDN MELLI+INACK A +SRVTAV+P F Y+RQ
Sbjct: 61 GEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQ 97
>Hs4506127 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 318
Score = 216 bits (549), Expect = 8e-56
Identities = 111/246 (45%), Positives = 154/246 (62%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P +I+ +I +++C +VSP
Sbjct: 111 LVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIRENISEWRNCTIVSP 170
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKER+
Sbjct: 171 DAGGAKRVTSIADRLNVDFALIHKERKKA------------------------------- 199
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V+ +LVGDV+++ I+VDD+ DT TI AA L GAT++YA++THG
Sbjct: 200 --------NEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHG 251
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG A++RI + + ++VTN+IPQ++ +K +++V+D+S I AEAIRR HNGES+
Sbjct: 252 IFSGPAISRINNACFEAVVVTNTIPQEDKMK--HCSKIQVIDISMILAEAIRRTHNGESV 309
Query: 461 SILFEH 466
S LF H
Sbjct: 310 SYLFSH 315
Score = 125 bits (313), Expect = 2e-28
Identities = 61/97 (62%), Positives = 74/97 (75%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M NI +F+GSSH DL KI + LG+E +V KFSN ET + I ESVR +DVY++QSGC
Sbjct: 1 MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGC 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G +NDN MELLI+INACK A ASRVTAV+P F Y+RQ
Sbjct: 61 GEINDNLMELLIMINACKIASASRVTAVIPCFPYARQ 97
>7294894 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 341
Score = 214 bits (544), Expect = 3e-55
Identities = 111/246 (45%), Positives = 155/246 (62%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P +I+ +IP +++ ++VSP
Sbjct: 134 LVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIVSP 193
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKER+
Sbjct: 194 DAGGAKRVTSIADRLNVEFALIHKERKKA------------------------------- 222
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V + +LVGDV++K I+VDD+ DT TI AA L + GATK+YA++THG
Sbjct: 223 --------NEVASMVLVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAILTHG 274
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG A++RI + + ++VTN+IPQD ++ +++ +DVS +FAEA+RR HNGES+
Sbjct: 275 IFSGPAISRINNACFEAVVVTNTIPQDGHMR--DCPKIQCIDVSMMFAEAVRRTHNGESV 332
Query: 461 SILFEH 466
S LF +
Sbjct: 333 SYLFSN 338
Score = 118 bits (295), Expect = 2e-26
Identities = 59/97 (60%), Positives = 73/97 (74%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M NI VF+G+SH DL +I + LGI+ +V KFSN ET + I ESVR +DVY++QSG
Sbjct: 1 MPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGS 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G +NDN MELLI+INACK A ASRVTAV+P F Y+RQ
Sbjct: 61 GEINDNLMELLIMINACKIASASRVTAVIPCFPYARQ 97
>7294893 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 318
Score = 214 bits (544), Expect = 3e-55
Identities = 111/246 (45%), Positives = 155/246 (62%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P +I+ +IP +++ ++VSP
Sbjct: 111 LVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLKWIKENIPEWKNSIIVSP 170
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKER+
Sbjct: 171 DAGGAKRVTSIADRLNVEFALIHKERKKA------------------------------- 199
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V + +LVGDV++K I+VDD+ DT TI AA L + GATK+YA++THG
Sbjct: 200 --------NEVASMVLVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAILTHG 251
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG A++RI + + ++VTN+IPQD ++ +++ +DVS +FAEA+RR HNGES+
Sbjct: 252 IFSGPAISRINNACFEAVVVTNTIPQDGHMR--DCPKIQCIDVSMMFAEAVRRTHNGESV 309
Query: 461 SILFEH 466
S LF +
Sbjct: 310 SYLFSN 315
Score = 118 bits (295), Expect = 2e-26
Identities = 59/97 (60%), Positives = 73/97 (74%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M NI VF+G+SH DL +I + LGI+ +V KFSN ET + I ESVR +DVY++QSG
Sbjct: 1 MPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGS 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G +NDN MELLI+INACK A ASRVTAV+P F Y+RQ
Sbjct: 61 GEINDNLMELLIMINACKIASASRVTAVIPCFPYARQ 97
>CE29454 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 318
Score = 211 bits (538), Expect = 1e-54
Identities = 117/246 (47%), Positives = 144/246 (57%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P YI+ IPN+Q V+VSP
Sbjct: 110 LVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSP 169
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKE
Sbjct: 170 DAGGAKRVTSIADRLNVDFALIHKE----------------------------------- 194
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
S N V LVG V K I+VDD+ DT TI AA L + GA K+YA HG
Sbjct: 195 --SKRANE--VEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHG 250
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG AL R+ S + ++VTN+IPQDE +K +++ +D+S I AEAIRR HNGES+
Sbjct: 251 IFSGPALTRLNASKFEAVVVTNTIPQDENMK--KCSKIQCIDISMILAEAIRRTHNGESV 308
Query: 461 SILFEH 466
S LF H
Sbjct: 309 SYLFSH 314
Score = 114 bits (284), Expect = 4e-25
Identities = 56/92 (60%), Positives = 69/92 (74%)
Query: 6 VFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCGHVND 65
VF+GSSH DL +ICE L +E S+ L KFSN ET++ I ESVR +DVY+IQS G +ND
Sbjct: 5 VFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAAGEIND 64
Query: 66 NFMELLILINACKTADASRVTAVMPYFSYSRQ 97
N MELLI+INACK A + RV AV+P F Y+RQ
Sbjct: 65 NLMELLIMINACKIASSCRVAAVIPAFPYARQ 96
>CE27199 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 419
Score = 211 bits (538), Expect = 1e-54
Identities = 117/246 (47%), Positives = 144/246 (57%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P YI+ IPN+Q V+VSP
Sbjct: 211 LVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSP 270
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKE
Sbjct: 271 DAGGAKRVTSIADRLNVDFALIHKE----------------------------------- 295
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
S N V LVG V K I+VDD+ DT TI AA L + GA K+YA HG
Sbjct: 296 --SKRANE--VEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHG 351
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG AL R+ S + ++VTN+IPQDE +K +++ +D+S I AEAIRR HNGES+
Sbjct: 352 IFSGPALTRLNASKFEAVVVTNTIPQDENMK--KCSKIQCIDISMILAEAIRRTHNGESV 409
Query: 461 SILFEH 466
S LF H
Sbjct: 410 SYLFSH 415
Score = 118 bits (295), Expect = 2e-26
Identities = 59/97 (60%), Positives = 72/97 (73%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M NI VF+GSSH DL +ICE L +E S+ L KFSN ET++ I ESVR +DVY+IQS
Sbjct: 101 MPNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAA 160
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G +NDN MELLI+INACK A + RV AV+P F Y+RQ
Sbjct: 161 GEINDNLMELLIMINACKIASSCRVAAVIPAFPYARQ 197
>CE00745 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 377
Score = 211 bits (538), Expect = 1e-54
Identities = 117/246 (47%), Positives = 144/246 (57%), Gaps = 41/246 (16%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+AN+L+ +GADH+ITMDLH SQ QGFFDIPVDNLY +P YI+ IPN+Q V+VSP
Sbjct: 169 LVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAILKYIKESIPNWQTSVIVSP 228
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR IAD L + FA+IHKE
Sbjct: 229 DAGGAKRVTSIADRLNVDFALIHKE----------------------------------- 253
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
S N V LVG V K I+VDD+ DT TI AA L + GA K+YA HG
Sbjct: 254 --SKRANE--VEKMTLVGSVEGKVAILVDDMADTCGTICMAADKLVEAGADKVYAFCVHG 309
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG AL R+ S + ++VTN+IPQDE +K +++ +D+S I AEAIRR HNGES+
Sbjct: 310 IFSGPALTRLNASKFEAVVVTNTIPQDENMK--KCSKIQCIDISMILAEAIRRTHNGESV 367
Query: 461 SILFEH 466
S LF H
Sbjct: 368 SYLFSH 373
Score = 118 bits (295), Expect = 2e-26
Identities = 59/97 (60%), Positives = 72/97 (73%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M NI VF+GSSH DL +ICE L +E S+ L KFSN ET++ I ESVR +DVY+IQS
Sbjct: 59 MPNIKVFSGSSHPDLSTRICERLQLEVSKASLKKFSNKETNVEIGESVRGEDVYIIQSAA 118
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G +NDN MELLI+INACK A + RV AV+P F Y+RQ
Sbjct: 119 GEINDNLMELLIMINACKIASSCRVAAVIPAFPYARQ 155
>YHL011c [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 320
Score = 209 bits (531), Expect = 9e-54
Identities = 109/246 (44%), Positives = 156/246 (63%), Gaps = 42/246 (17%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+A++LTT+G DHVITMDLH SQ QGFFD+PVDNLY +P YI+ ++ NY D +++SP
Sbjct: 114 LMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKENV-NYMDSIIISP 172
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKRAA +AD L+L+FA+IHKER
Sbjct: 173 DAGGAKRAATLADRLDLNFALIHKER---------------------------------- 198
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V+ +LVGDV +K CIIVDD+ DT T+ +AA++L + A + A++THG
Sbjct: 199 -----ARANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHG 253
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
+ SG A+ I S +D+++ TN++P +E IK ++ V+D+S++ AE+IRR+HNGESI
Sbjct: 254 VLSGRAIENINNSKLDRVVCTNTVPFEEKIK--KCPKLAVIDISSVLAESIRRLHNGESI 311
Query: 461 SILFEH 466
S LF++
Sbjct: 312 SYLFKN 317
Score = 86.3 bits (212), Expect = 9e-17
Identities = 45/97 (46%), Positives = 64/97 (65%), Gaps = 1/97 (1%)
Query: 2 NNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVI-QSGC 60
N+I + A H L + + LG++ + KL + GE S SI ESVR++D+++I Q G
Sbjct: 4 NSIKLLAPDVHRGLAELVAKRLGLQLTSSKLKRDPTGEVSFSIGESVRDQDIFIITQIGS 63
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
G VND +ELLI+INA KTA A R+TA++P F Y+RQ
Sbjct: 64 GVVNDRVLELLIMINASKTASARRITAIIPNFPYARQ 100
>SPCC1620.06c [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 321
Score = 204 bits (520), Expect = 2e-52
Identities = 110/245 (44%), Positives = 150/245 (60%), Gaps = 42/245 (17%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPN-YQDCVVVS 279
L+AN+L T+G +H+ITMDLH SQ QGFF++PVDNLY +P YI+ +I V+VS
Sbjct: 113 LVANMLQTAGCNHIITMDLHASQIQGFFNVPVDNLYAEPSVLRYIRENIDTTVNPTVIVS 172
Query: 280 PDAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIR 339
PDAGGAKRA +AD L+L FA+IHKER+
Sbjct: 173 PDAGGAKRATALADRLDLDFALIHKERQKA------------------------------ 202
Query: 340 TSLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITH 399
V+ +LVGDVR+K I+VDD+ DT T+ AAK LKD GA +YA++TH
Sbjct: 203 ---------NEVSRMVLVGDVRDKLAILVDDMADTCGTLGLAAKTLKDNGAKAVYAIVTH 253
Query: 400 GIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGES 459
GI SG A+ I +S ++K+IVTN+IP D+ + ++E +D+S + AE IRRIH+GES
Sbjct: 254 GILSGKAIKVINESALEKVIVTNTIPHDDKRSL--CSKIETIDISGVLAECIRRIHHGES 311
Query: 460 ISILF 464
+S+LF
Sbjct: 312 VSVLF 316
Score = 112 bits (281), Expect = 9e-25
Identities = 48/96 (50%), Positives = 76/96 (79%)
Query: 2 NNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCG 61
N+I +FAG+SH +L K+ +G+ +V + ++SN ETS++I ESVR++DV+++Q+GCG
Sbjct: 4 NSIKIFAGNSHPELAEKVARRIGLSLGKVAVVQYSNRETSVTIGESVRDEDVFILQTGCG 63
Query: 62 HVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
+ND+ MELLI+INAC++A A R+TA++P F Y+RQ
Sbjct: 64 SINDHLMELLIMINACRSASARRITAIIPCFPYARQ 99
>YBL068w [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 355
Score = 202 bits (513), Expect = 1e-51
Identities = 109/246 (44%), Positives = 149/246 (60%), Gaps = 44/246 (17%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+ANLL T+GADHVITMDLH SQ QGFF IPVDNLY +P YI+ ++ + ++VSP
Sbjct: 151 LVANLLQTAGADHVITMDLHASQIQGFFHIPVDNLYAEPSVLNYIRARKTDFDNAILVSP 210
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR A +AD L+L+FA+IHKER+
Sbjct: 211 DAGGAKRVAALADKLDLNFALIHKERQKA------------------------------- 239
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V+ +LVGDV NK C++VDD+ DT T+ +A L + GA ++ A++THG
Sbjct: 240 --------NEVSKMVLVGDVTNKSCLLVDDMADTCGTLVKACDTLMEHGAKEVIAIVTHG 291
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG A ++ S + +I+ TN++P D + + AD++ D+S FAEAIRR+HNGES+
Sbjct: 292 IFSGSAREKLRNSRLSRIVCTNTVPVDLDLPI--ADQI---DISPTFAEAIRRLHNGESV 346
Query: 461 SILFEH 466
S LF H
Sbjct: 347 SYLFTH 352
Score = 99.8 bits (247), Expect = 8e-21
Identities = 54/112 (48%), Positives = 78/112 (69%), Gaps = 7/112 (6%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
+N+I + AG+SH DL +I + LGI S+V + ++SN ETS++I ES+R++DVY+IQ+G
Sbjct: 39 INSIKLLAGNSHPDLAEQISKKLGIPLSKVGVYQYSNKETSVTIGESLRDEDVYIIQTGI 98
Query: 61 G--HVNDNFMELLILINACKTADASRVTAVMPYFSYSRQPD-----IPYTAK 105
G +ND MELLILI+AC+ A A ++T V+P F Y+RQ P TAK
Sbjct: 99 GEQEINDFLMELLILIHACQIASARKITTVIPNFPYARQDKKDKSRAPITAK 150
>YER099c [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 318
Score = 194 bits (493), Expect = 2e-49
Identities = 107/246 (43%), Positives = 145/246 (58%), Gaps = 45/246 (18%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
LIANLL T+G DHVITMDLH SQ QGFF IPVDNLY +P YI+ ++ + ++VSP
Sbjct: 115 LIANLLETAGCDHVITMDLHASQIQGFFHIPVDNLYGEPSVLNYIRTKT-DFNNAILVSP 173
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
DAGGAKR A +AD L+++FA+IHKER+
Sbjct: 174 DAGGAKRVASLADKLDMNFALIHKERQKA------------------------------- 202
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
V+ +LVGDV K C+++DD+ DT T+ +A L D GA ++ A++THG
Sbjct: 203 --------NEVSRMLLVGDVAGKSCLLIDDMADTCGTLVKACDTLMDHGAKEVIAIVTHG 254
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
IFSG A ++ S + +I+ TN++P D L D V+ +D+S AEAIRR+HNGES+
Sbjct: 255 IFSGSAREKLINSRLSRIVCTNTVPVD-----LDLDIVDQVDISPTIAEAIRRLHNGESV 309
Query: 461 SILFEH 466
S LF H
Sbjct: 310 SYLFTH 315
Score = 100 bits (250), Expect = 4e-21
Identities = 55/111 (49%), Positives = 76/111 (67%), Gaps = 7/111 (6%)
Query: 2 NNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCG 61
N+I + AG+SH L I + LG+ S+V + ++SN ETS++I ES+R++DVY+IQ+G G
Sbjct: 4 NSIKLLAGNSHPGLAELISQRLGVPLSKVGVYQYSNKETSVTIGESIRDEDVYIIQTGYG 63
Query: 62 --HVNDNFMELLILINACKTADASRVTAVMPYFSYSRQPD-----IPYTAK 105
+ND MELLILI+ACKTA R+TAV+P F Y+RQ P TAK
Sbjct: 64 EHEINDFLMELLILIHACKTASVRRITAVIPNFPYARQDKKDKSRAPITAK 114
>Hs4506133 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-associated
protein
Length = 369
Score = 174 bits (442), Expect = 2e-43
Identities = 100/249 (40%), Positives = 148/249 (59%), Gaps = 16/249 (6%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+A+++ +G H+ITMDLH + QGFF+IPVDNL P YIQ IP+Y++ V+V+
Sbjct: 129 LLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAK 188
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERR---SQLLKGPPGATLTSGGGVPVSTKPLIESLD 337
AKRA A+ L L A+IH E + S L+ G + S + SL+
Sbjct: 189 SPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVR------SVAAIHPSLE 242
Query: 338 IRTSLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALI 397
I + K +VGDV + IIVDD++D + AA+ LK++GA KI+ +
Sbjct: 243 IPMLIP-----KEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMA 297
Query: 398 THGIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNG 457
THG+ S DA RI +S ID+++VTN+IP + ++ L +++ +D+S I +EAIRRIHNG
Sbjct: 298 THGLLSSDAPRRIEESAIDEVVVTNTIPHE--VQKLQCPKIKTVDISMILSEAIRRIHNG 355
Query: 458 ESISILFEH 466
ES+S LF +
Sbjct: 356 ESMSYLFRN 364
Score = 84.7 bits (208), Expect = 3e-16
Identities = 42/90 (46%), Positives = 61/90 (67%)
Query: 8 AGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCGHVNDNF 67
+ SS ++L KI E LG+E +V++ + N ET + I+ESVR KDV++IQ+ VN
Sbjct: 27 SNSSCMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTI 86
Query: 68 MELLILINACKTADASRVTAVMPYFSYSRQ 97
MELLI++ ACKT+ A + V+PYF YS+Q
Sbjct: 87 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ 116
>7301964 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-associated
protein
Length = 386
Score = 174 bits (442), Expect = 2e-43
Identities = 105/269 (39%), Positives = 153/269 (56%), Gaps = 25/269 (9%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+A ++ TSG H+ITMDLH + QGFFDIPVDNL P YIQ IP+Y++ V+V+
Sbjct: 115 LLAKMMCTSGLTHIITMDLHQKEIQGFFDIPVDNLRASPFLLQYIQESIPDYRNSVIVAR 174
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQ-------LLKGPPGATLTSGGG------VPV 327
+ G AK+A A+ L L A+IH E++ PP + ++ G +P
Sbjct: 175 NPGVAKKANSYAERLRLGLAVIHGEQKETDADEVDGRYSPPPTSAYSNLLGNSVEMCLPA 234
Query: 328 STK-------PLIESLDIRTSLSNNGNNKYVNTT---MLVGDVRNKECIIVDDLVDTSYT 377
+ + P + TS+S V +VGDV + I+VDDL+D
Sbjct: 235 TPRNSTPQHAPTSSARQRTTSVSVGVPEHIVKVKPPLTIVGDVSGRIAIMVDDLIDDVQA 294
Query: 378 ITRAAKLLKDQGATKIYALITHGIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADR 437
AA++LK+ GA KIY L THG+ S DA ++ +S ID+I+VTN+IP + I+ L +
Sbjct: 295 FVAAAEMLKENGACKIYVLATHGLLSSDAPRQLDESPIDEIVVTNTIPHE--IQKLQCHK 352
Query: 438 VEVLDVSNIFAEAIRRIHNGESISILFEH 466
++ +D+S + AEAIRRIHN ES+S LF +
Sbjct: 353 IKTIDISILIAEAIRRIHNKESMSYLFRN 381
Score = 91.3 bits (225), Expect = 3e-18
Identities = 43/96 (44%), Positives = 62/96 (63%)
Query: 2 NNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCG 61
++IV+ G+SH DL N + E +GI+ + SN ET + I +SVR KD+Y+IQ+G
Sbjct: 7 SDIVIINGNSHPDLANMVAERMGIKNGGCSVFHKSNRETIVEISDSVRGKDIYIIQTGTK 66
Query: 62 HVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
N+N MELLI+ ACKT+ A + V+PY YS+Q
Sbjct: 67 DANNNIMELLIMAYACKTSSARSIVGVIPYLPYSKQ 102
>Hs4506131 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-associated
protein
Length = 356
Score = 172 bits (435), Expect = 1e-42
Identities = 95/247 (38%), Positives = 144/247 (57%), Gaps = 13/247 (5%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+A++L +G H+ITMDLH + QGFF PVDNL P YIQ IPNY++ V+V+
Sbjct: 117 LLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAK 176
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
AKRA A+ L L A+IH E + L G + P++++ +
Sbjct: 177 SPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGR----------HSPPMVKNATVHP 226
Query: 341 SLS-NNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITH 399
L K +VGDV + IIVDD++D + AA++LK++GA KIY + TH
Sbjct: 227 GLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATH 286
Query: 400 GIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGES 459
GI S +A I +S +D+++VTN++P + ++ L +++ +D+S I +EAIRRIHNGES
Sbjct: 287 GILSAEAPRLIEESSVDEVVVTNTVPHE--VQKLQCPKIKTVDISLILSEAIRRIHNGES 344
Query: 460 ISILFEH 466
++ LF +
Sbjct: 345 MAYLFRN 351
Score = 68.2 bits (165), Expect = 3e-11
Identities = 36/84 (42%), Positives = 53/84 (62%)
Query: 14 DLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCGHVNDNFMELLIL 73
+L +I E LG E + + + +NGET + I+E VR +D+++IQ+ VN MELLI+
Sbjct: 21 ELAKRITERLGAELGKSVVYQETNGETRVEIKEFVRGQDIFIIQTIPRDVNTAVMELLIM 80
Query: 74 INACKTADASRVTAVMPYFSYSRQ 97
A KTA A + V+PYF YS+Q
Sbjct: 81 AYALKTACARNIIGVIPYFPYSKQ 104
>At1g32380 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 400
Score = 147 bits (372), Expect = 3e-35
Identities = 84/248 (33%), Positives = 131/248 (51%), Gaps = 43/248 (17%)
Query: 218 AGTLIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVV 277
A L+ANL+T +GAD V+ DLH Q G+FDIPVD++YC+P+ Y+ + +D VV
Sbjct: 194 AAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYCQPVILDYLASKSISSEDLVV 253
Query: 278 VSPDAGGAKRAAKIADVL-ELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESL 336
VSPD GG RA A L + A++ K R
Sbjct: 254 VSPDVGGVARARAFAKKLSDAPLAIVDKRR------------------------------ 283
Query: 337 DIRTSLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYAL 396
+G+N L+GDV+ K ++VDD++DT+ TI + A LL ++GA ++YA
Sbjct: 284 --------HGHN-VAEVMNLIGDVKGKVAVMVDDIIDTAGTIVKGAALLHEEGAREVYAC 334
Query: 397 ITHGIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHN 456
TH +FS A+ R+ ++ ++IVTN++P E ++ +L V+N+ E I R+H+
Sbjct: 335 CTHAVFSPPAIERLSSGLLQEVIVTNTLPVAEKNYF---PQLTILSVANLLGETIWRVHD 391
Query: 457 GESISILF 464
S+S +F
Sbjct: 392 DSSVSSIF 399
Score = 85.5 bits (210), Expect = 2e-16
Identities = 38/91 (41%), Positives = 65/91 (70%)
Query: 6 VFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCGHVND 65
+F+G+++ L +I +G+E +V + +F++GE + ++ESVR DV+++Q C N+
Sbjct: 92 LFSGTANPALSQEIAWYMGLELGKVSIKRFADGEIYVQLKESVRGCDVFLVQPTCTPTNE 151
Query: 66 NFMELLILINACKTADASRVTAVMPYFSYSR 96
N MELLI+++AC+ A A +VTAV+PYF Y+R
Sbjct: 152 NLMELLIMVDACRRASAKKVTAVIPYFGYAR 182
>At2g35390 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 352
Score = 147 bits (370), Expect = 4e-35
Identities = 87/247 (35%), Positives = 128/247 (51%), Gaps = 41/247 (16%)
Query: 218 AGTLIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVV 277
A L+ANL+T +GAD V+ DLH Q G+FDIPVD++YC+P+ Y+ +D VV
Sbjct: 146 AAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYCQPVILDYLASKSIPSEDLVV 205
Query: 278 VSPDAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLD 337
VSPD GG RA A L + I +RRS
Sbjct: 206 VSPDVGGVARARAFAKKLSDAPLAIVDKRRS----------------------------- 236
Query: 338 IRTSLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALI 397
G+N L+GDVR K I+VDD++DT+ TI + A LL +GA ++YA
Sbjct: 237 --------GHN-VAEVMNLIGDVRGKVAIMVDDMIDTAGTIVKGAALLHQEGAREVYACC 287
Query: 398 THGIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNG 457
TH +FS A+ R+ ++ ++IVTN++P E ++ +L V+N+ E I R+H+
Sbjct: 288 THAVFSPPAIERLSGGLLQEVIVTNTLPVAEKNYF---PQLTILSVANLLGETIWRVHDD 344
Query: 458 ESISILF 464
S+S +F
Sbjct: 345 SSVSSIF 351
Score = 87.0 bits (214), Expect = 5e-17
Identities = 38/91 (41%), Positives = 65/91 (70%)
Query: 6 VFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCGHVND 65
+F+G+++ L +I +G++ +V + +F++GE + ++ESVR DVY++Q C N+
Sbjct: 44 LFSGTANPALAQEIAWYMGLDLGKVNIKRFADGEIYVQLQESVRGCDVYLVQPTCTPTNE 103
Query: 66 NFMELLILINACKTADASRVTAVMPYFSYSR 96
N MELLI+++AC+ A A +VTAV+PYF Y+R
Sbjct: 104 NLMELLIMVDACRRASAKKVTAVIPYFGYAR 134
>CE03789 [EF] KOG1503 Phosphoribosylpyrophosphate synthetase-associated
protein
Length = 353
Score = 144 bits (363), Expect = 3e-34
Identities = 84/244 (34%), Positives = 138/244 (56%), Gaps = 14/244 (5%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
L+A ++ +GA ++++DL+ + QGFF PVDNL P +I+ +IP+Y++ ++V+
Sbjct: 117 LVAEMICKAGASRLVSLDLYKKEIQGFFSCPVDNLRASPFFLQHIKTNIPDYKNAIIVAK 176
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESLDIRT 340
G +A AD L L A+IH E++ + G L G P P + S D
Sbjct: 177 SPGVMNKATSYADRLRLGVAVIHGEQKDEEESG-----LEDGRQSP---PPNVTSYDFLP 228
Query: 341 SLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYALITHG 400
+ +K +VGDV + I+VDD++D + + AA++LK +GA KIY + THG
Sbjct: 229 A----QESKQKPPLTVVGDVGGRIAIMVDDIIDDAQSFVAAAEVLKARGAYKIYVIATHG 284
Query: 401 IFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESI 460
+ S DA + S I ++IVTN++P D ++ + +++ +DVS + EAIRRI + ES+
Sbjct: 285 VLSSDAPALLEASPITEVIVTNTVPHD--LQKMRCHKIKTVDVSLMICEAIRRIFHNESM 342
Query: 461 SILF 464
LF
Sbjct: 343 GQLF 346
Score = 85.5 bits (210), Expect = 2e-16
Identities = 40/96 (41%), Positives = 64/96 (66%)
Query: 2 NNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCG 61
+ +V+ G+SH +L + E L I + + +N ETS+ I++SVR K V+++QSG
Sbjct: 9 SGMVLLTGNSHPELAKMVSERLEIRLGEATVYNKTNRETSVDIKQSVRGKHVFILQSGSK 68
Query: 62 HVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
+VN++ MELL+LI ACKT+ + +T +MPY YS+Q
Sbjct: 69 NVNNDVMELLVLIYACKTSMSKTITVIMPYLPYSKQ 104
>At2g44530 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 386
Score = 142 bits (357), Expect = 1e-33
Identities = 85/245 (34%), Positives = 128/245 (51%), Gaps = 43/245 (17%)
Query: 218 AGTLIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVV 277
A L+ANL+T SGAD V+ DLH Q G+FDIPVD++Y +P+ Y+ + +D VV
Sbjct: 182 AAKLVANLITQSGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKAISSEDLVV 241
Query: 278 VSPDAGGAKRAAKIADVL-ELSFAMIHKERRSQLLKGPPGATLTSGGGVPVSTKPLIESL 336
VSPD GG RA A L + A++ K R
Sbjct: 242 VSPDVGGVARARAFAKKLSDAPLAIVDKRR------------------------------ 271
Query: 337 DIRTSLSNNGNNKYVNTTMLVGDVRNKECIIVDDLVDTSYTITRAAKLLKDQGATKIYAL 396
+G+N L+GDV+ K I+VDD++DT+ TI++ A LL +GA ++YA
Sbjct: 272 --------HGHN-VAEVMNLIGDVKGKVAIMVDDMIDTAGTISKGAALLHQEGAREVYAC 322
Query: 397 ITHGIFSGDALNRIGQSVIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHN 456
TH +FS A++R+ + ++I+TN+IP E ++ VL V+N+ E I R+H+
Sbjct: 323 TTHAVFSPPAISRLSSGLFQEVIITNTIPLSEKNYF---PQLTVLSVANLLGETIWRVHD 379
Query: 457 GESIS 461
S+S
Sbjct: 380 DCSVS 384
Score = 85.9 bits (211), Expect = 1e-16
Identities = 37/91 (40%), Positives = 65/91 (70%)
Query: 6 VFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGCGHVND 65
+F+G+++ L +I LG++ ++K+ +F++GE + ++ESVR DV+++Q C N+
Sbjct: 80 IFSGTANPILAQEISCYLGLDLGKIKIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANE 139
Query: 66 NFMELLILINACKTADASRVTAVMPYFSYSR 96
N MELL++I+AC+ A A +TAV+PYF Y+R
Sbjct: 140 NLMELLVMIDACRRASAKTITAVIPYFGYAR 170
>SPAC4A8.14 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 409
Score = 110 bits (274), Expect = 6e-24
Identities = 52/97 (53%), Positives = 69/97 (70%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M + + G SH +L++ I LGI V L +F+NGETS+ I ESVR+KDV+++QSG
Sbjct: 1 MKSATIIGGGSHPELLHLISNRLGITPCDVSLKRFANGETSVEIRESVRDKDVFILQSGS 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
VND+ MELLI+I+ACK A R+TAVMPYF YS+Q
Sbjct: 61 STVNDSLMELLIIISACKGGSAKRITAVMPYFPYSKQ 97
Score = 99.0 bits (245), Expect = 1e-20
Identities = 44/87 (50%), Positives = 64/87 (72%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
++ANLLT +G DH+IT+DLH SQ QGFF PVDNLY +P +I+ ++ ++++ VVVS
Sbjct: 111 MVANLLTVAGVDHIITLDLHASQMQGFFTRPVDNLYAEPNIAEWIRRNVDDWEEAVVVSK 170
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERR 307
+ GGAKR +AD L L FA+I+ +R+
Sbjct: 171 NPGGAKRVTSLADTLNLDFALINTDRQ 197
Score = 80.9 bits (198), Expect = 4e-15
Identities = 46/112 (41%), Positives = 68/112 (60%), Gaps = 3/112 (2%)
Query: 356 LVGDVRNKECIIVDDLVDTSYTITRAAK-LLKDQGATKIYALITHGIFSGDALNRIGQ-S 413
LVGDV K +++DD ++ A++ L+K GA ++ + THGIF L +
Sbjct: 296 LVGDVNGKTALLIDDTIENPTAFIVASEHLVKRCGAKRVIVIGTHGIFQNKCLKDLQSCE 355
Query: 414 VIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESISILFE 465
I++I+VTN+ P VL D++ V+D+S + AEAIRR HNGESIS LF+
Sbjct: 356 YIEQIVVTNTYPIKPQA-VLECDKLTVIDISGVLAEAIRRTHNGESISFLFK 406
>YKL181w [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 427
Score = 108 bits (269), Expect = 2e-23
Identities = 51/97 (52%), Positives = 70/97 (71%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M +F G+SH +L N +C+ LGIE + L KF+NGETS+ I SVR++DVYVIQSG
Sbjct: 1 MRKCKIFVGNSHPELGNMVCQRLGIEPAPCTLKKFANGETSVQIGVSVRDEDVYVIQSGS 60
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSRQ 97
+ND+ MELLIL++AC+ A ++TAV+P F YS+Q
Sbjct: 61 PSINDDIMELLILVSACRGGSARKITAVIPQFPYSKQ 97
Score = 101 bits (252), Expect = 2e-21
Identities = 47/87 (54%), Positives = 64/87 (73%)
Query: 221 LIANLLTTSGADHVITMDLHDSQFQGFFDIPVDNLYCKPITQAYIQHHIPNYQDCVVVSP 280
++ANLL +GADHV++MDLH SQ QGFF PVDNLY P +I+ ++ +Y+D VVVS
Sbjct: 111 MLANLLVMAGADHVVSMDLHASQMQGFFTKPVDNLYGGPSLAKWIRENVEDYEDAVVVSK 170
Query: 281 DAGGAKRAAKIADVLELSFAMIHKERR 307
+ GG KR +AD L+++FAMIH +RR
Sbjct: 171 NPGGTKRVTALADSLKINFAMIHTDRR 197
Score = 95.1 bits (235), Expect = 2e-19
Identities = 52/112 (46%), Positives = 77/112 (68%), Gaps = 3/112 (2%)
Query: 356 LVGDVRNKECIIVDDLVDTSYTITRAAK-LLKDQGATKIYALITHGIFSGDALNRIGQS- 413
LVG+VR + II+DD++D + AA+ L+++ GA K+Y + THGIF+GD L + +S
Sbjct: 312 LVGNVRGRSAIILDDMIDRPGSFISAAEHLVQNCGAKKVYVVATHGIFTGDCLEELEKSD 371
Query: 414 VIDKIIVTNSIPQDETIKVLGADRVEVLDVSNIFAEAIRRIHNGESISILFE 465
ID I+VTN+ P ++ G+ ++ +DVS IFAE IRR H GESIS+LF+
Sbjct: 372 AIDTIVVTNTYPISGE-RIAGSKKLVTIDVSPIFAECIRRDHYGESISVLFD 422
>Hs20542182 [FE] KOG1448 Ribose-phosphate pyrophosphokinase
Length = 271
Score = 52.0 bits (123), Expect = 2e-06
Identities = 39/113 (34%), Positives = 60/113 (52%), Gaps = 8/113 (7%)
Query: 1 MNNIVVFAGSSHLDLVNKICENLGIERSQVKLGKFSNGETSISIEESVREKDVYVIQSGC 60
M+N+V+ GSS L L K+ + G+E +V KFSN E SI E +R++ YVI
Sbjct: 42 MSNMVLL-GSSSLGLAQKVVKRWGLELGKVVTKKFSNQEVSIVSGERMRDQAAYVIVK-- 98
Query: 61 GHVNDNFMELLILINACKTADASRVTAVMPYFSYSR--QPDIPYTAKGAPLIS 111
+ND + L + N CK +S + AV+ Y++ Q D + A A L++
Sbjct: 99 --INDT-LTSLAMTNVCKATWSSGMKAVLSCSPYAQQDQKDKSHPAVSAKLVA 148
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,551,447
Number of Sequences: 60738
Number of extensions: 1098305
Number of successful extensions: 3064
Number of sequences better than 1.0e-05: 24
Number of HSP's better than 0.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 2964
Number of HSP's gapped (non-prelim): 66
length of query: 468
length of database: 30,389,216
effective HSP length: 110
effective length of query: 358
effective length of database: 23,708,036
effective search space: 8487476888
effective search space used: 8487476888
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)