ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1051 good E KOG1706 Amino acid transport and metabolism Argininosuccinate synthase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1051 367627 368886 420
(420 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOL058w [E] KOG1706 Argininosuccinate synthase 709 0.0
SPBC428.05c [E] KOG1706 Argininosuccinate synthase 510 e-144
Hs16950633 [E] KOG1706 Argininosuccinate synthase 414 e-115
Hs4557337 [E] KOG1706 Argininosuccinate synthase 412 e-115
7298897 [E] KOG1706 Argininosuccinate synthase 363 e-100
Hs17458794 [E] KOG1706 Argininosuccinate synthase 306 4e-83
Hs20545296 [E] KOG1706 Argininosuccinate synthase 298 1e-80
Hs20539742 [E] KOG1706 Argininosuccinate synthase 291 1e-78
At4g24830 [E] KOG1706 Argininosuccinate synthase 278 1e-74
Hs18602887 [E] KOG1706 Argininosuccinate synthase 208 1e-53
Hs17468745 [E] KOG1706 Argininosuccinate synthase 152 7e-37
Hs18573672 [E] KOG1706 Argininosuccinate synthase 124 2e-28
Hs22043876 [E] KOG1706 Argininosuccinate synthase 115 2e-25
Hs17452937 [E] KOG1706 Argininosuccinate synthase 87 4e-17
>YOL058w [E] KOG1706 Argininosuccinate synthase
Length = 420
Score = 709 bits (1831), Expect = 0.0
Identities = 349/420 (83%), Positives = 378/420 (89%)
Query: 1 MSKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVL 60
MSKGKVCLAYSGGLDTSVILAWLL+QGYEVVAFMANVGQEEDF+AA++KAL IGA KFV
Sbjct: 1 MSKGKVCLAYSGGLDTSVILAWLLDQGYEVVAFMANVGQEEDFDAAKEKALKIGACKFVC 60
Query: 61 VDCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGK 120
VDCRE+FVKD+LFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGK
Sbjct: 61 VDCREDFVKDILFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGK 120
Query: 121 GNDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWST 180
GNDQIRFEL FYALKPDVK I PWR P FF+RFAGRKDLL YAA+K IPV QT +KPWST
Sbjct: 121 GNDQIRFELSFYALKPDVKCITPWRMPEFFERFAGRKDLLDYAAQKGIPVAQTKAKPWST 180
Query: 181 DENLAHISYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLTYKDAA 240
DEN AHISYEAGILEDP+ TPP DMWKLI P DAPDQPQDL I FE+GLPVKLTY D
Sbjct: 181 DENQAHISYEAGILEDPDTTPPKDMWKLIVDPMDAPDQPQDLTIDFERGLPVKLTYTDNK 240
Query: 241 SGKETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDL 300
+ KE + T PLD+FL ++ LARANGVGRIDIVE+RYINLKSRGCYEQAPL+VLR+AHVDL
Sbjct: 241 TSKEVSVTKPLDVFLAASNLARANGVGRIDIVEDRYINLKSRGCYEQAPLTVLRKAHVDL 300
Query: 301 EGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKG 360
EGLTLDKEVR LRD FVTPNYSRL+YNG PECEYIRSMIQPSQ++VNGTVR+RLYKG
Sbjct: 301 EGLTLDKEVRQLRDSFVTPNYSRLIYNGFLLHPECEYIRSMIQPSQNSVNGTVRVRLYKG 360
Query: 361 NIIVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKYGESKAAKGEELTL 420
N+I+LGR ++TE LY+P ESSMD LTGF PTDTTGFIAIQAIR+KKYGESK KGEELTL
Sbjct: 361 NVIILGRSTKTEKLYDPTESSMDELTGFLPTDTTGFIAIQAIRIKKYGESKKTKGEELTL 420
>SPBC428.05c [E] KOG1706 Argininosuccinate synthase
Length = 410
Score = 510 bits (1314), Expect = e-144
Identities = 250/404 (61%), Positives = 308/404 (75%), Gaps = 6/404 (1%)
Query: 8 LAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLVDCREEF 67
LAYSGGLDTS ILAWL+E+G+EV+ +MANVGQEED++AA +KAL +GA K + D REEF
Sbjct: 10 LAYSGGLDTSCILAWLIEEGWEVICYMANVGQEEDWDAAREKALKVGAKKVYVEDLREEF 69
Query: 68 VKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKGNDQIRF 127
+ D + PA Q NA+YE+VYLLGTSLARP+IA+ QI +A++E C AVSHGCTGKGNDQ+RF
Sbjct: 70 INDTVIPAAQANAIYENVYLLGTSLARPIIARRQIQIAEKENCIAVSHGCTGKGNDQVRF 129
Query: 128 ELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTDENLAHI 187
EL +YALKPDV+VIAPWR P FF+RFAGRKDLL YAA K IPV QT KPWS DEN+ H
Sbjct: 130 ELAYYALKPDVQVIAPWRLPVFFERFAGRKDLLEYAAAKGIPVTQTTKKPWSMDENIVHC 189
Query: 188 SYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLTYKDAASGKETTA 247
SYEAGILEDP+ TPP DMWKL P+DAPD+ ++L I FEKG P KL KD T
Sbjct: 190 SYEAGILEDPSMTPPKDMWKLTVDPKDAPDEVEELSIHFEKGAPTKLECKDG------TF 243
Query: 248 TSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDLEGLTLDK 307
+ + IF +AR NGVGRIDIVENR+ LKSRGCYE L++LR AH+DLEGLT+++
Sbjct: 244 SGVVSIFYQLNAIARRNGVGRIDIVENRFSGLKSRGCYETPGLTILRTAHMDLEGLTMER 303
Query: 308 EVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKGNIIVLGR 367
EVRALRDQFVT N +++LYNG +F+P + + SQ VNG V+L +YKGN+ VLGR
Sbjct: 304 EVRALRDQFVTFNLAKILYNGQFFSPCTRMLLAANNVSQEVVNGVVKLSVYKGNVTVLGR 363
Query: 368 YSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKYGESK 411
S+T +LY+ SSMD L GF PT T+GFI I+++R++ E K
Sbjct: 364 KSDTAHLYDEKLSSMDELGGFDPTWTSGFIQIESMRLRNSDEGK 407
>Hs16950633 [E] KOG1706 Argininosuccinate synthase
Length = 412
Score = 414 bits (1065), Expect = e-115
Identities = 209/407 (51%), Positives = 286/407 (69%), Gaps = 8/407 (1%)
Query: 2 SKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLV 61
SKG V LAYSGGLDTS IL WL EQGY+V+A++AN+GQ+EDFE A KKAL +GA K +
Sbjct: 3 SKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIE 62
Query: 62 DCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKG 121
D EFV++ ++PA+Q +A+YED YLLGTSLARP IA+ Q+++A++EG VSHG TGKG
Sbjct: 63 DVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKG 122
Query: 122 NDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTD 181
NDQ+RFEL Y+L P +KVIAPWR P F++RF GR DL+ YA + IP+ T PWS D
Sbjct: 123 NDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMD 182
Query: 182 ENLAHISYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDAA 240
ENL HISYEAGILE+P P ++ P AP+ P L+I F+KG+PVK+T KD
Sbjct: 183 ENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDG- 241
Query: 241 SGKETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDL 300
TT + L++F+ ++A +GVGRIDIVENR+I +KSRG YE ++L AH+D+
Sbjct: 242 ----TTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDI 297
Query: 301 EGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKG 360
E T+D+EVR ++ Q + ++ L+Y G + +PECE++R I SQ V G V++ + KG
Sbjct: 298 EAFTMDREVRKIK-QGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKG 356
Query: 361 NIIVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
+ +LGR S +LYN + SM++ ++PTD TGFI I ++R+K+Y
Sbjct: 357 QVYILGRESPL-SLYNEELVSMNVQGDYEPTDATGFININSLRLKEY 402
>Hs4557337 [E] KOG1706 Argininosuccinate synthase
Length = 412
Score = 412 bits (1058), Expect = e-115
Identities = 209/407 (51%), Positives = 285/407 (69%), Gaps = 8/407 (1%)
Query: 2 SKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLV 61
SKG V LAYSGGLDTS IL WL EQGY+V+A++AN+GQ+EDFE A KKAL +GA K +
Sbjct: 3 SKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIE 62
Query: 62 DCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKG 121
D EFV++ ++PA+Q +A+YED YLLGTSLARP IA+ Q+++A++EG VSHG TGKG
Sbjct: 63 DVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKG 122
Query: 122 NDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTD 181
NDQ+RFEL Y+L P +KVIAPWR P F++RF GR DL+ YA + IP+ T PWS D
Sbjct: 123 NDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMD 182
Query: 182 ENLAHISYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDAA 240
ENL HISYEAGILE+P P ++ P AP+ P L+I F+KG+PVK+T KD
Sbjct: 183 ENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDG- 241
Query: 241 SGKETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDL 300
TT + L++F+ ++A +GVGRIDIVENR+I +KSRG YE ++L AH+D+
Sbjct: 242 ----TTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDI 297
Query: 301 EGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKG 360
E T+D+EVR ++ Q + ++ L+Y G +PECE++R I SQ V G V++ + KG
Sbjct: 298 EAFTMDREVRKIK-QGLGLKFAELVYTGLRPSPECEFVRHCIAKSQERVEGKVQVSVLKG 356
Query: 361 NIIVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
+ +LGR S +LYN + SM++ ++PTD TGFI I ++R+K+Y
Sbjct: 357 QVYILGRESPL-SLYNEELVSMNVQGDYEPTDATGFININSLRLKEY 402
>7298897 [E] KOG1706 Argininosuccinate synthase
Length = 433
Score = 363 bits (932), Expect = e-100
Identities = 196/410 (47%), Positives = 269/410 (64%), Gaps = 8/410 (1%)
Query: 1 MSKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVL 60
M K V LAYSGGLDTS +L WLL++ YEV+ +A+VGQ+EDF AAEKKAL IGA K ++
Sbjct: 1 MPKETVILAYSGGLDTSCVLKWLLDKQYEVICVLADVGQKEDFTAAEKKALKIGAKKVIV 60
Query: 61 VDCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGK 120
D ++ FV+D ++PAVQ+ VYE+ YLLGTSLARP I+ A ++VA++ G ++HG TGK
Sbjct: 61 ADVKQSFVEDYIWPAVQMGLVYEERYLLGTSLARPCISVALMEVAREYGAKYLAHGATGK 120
Query: 121 GNDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWST 180
GNDQ+RFEL YALKPD+K+IAPWRD F +F GR+DL+AYA + I V + PWST
Sbjct: 121 GNDQVRFELCAYALKPDLKIIAPWRDVEFCCQFQGRQDLIAYAQQHGIEVSAKPATPWST 180
Query: 181 DENLAHISYEAGILEDPNQTPPNDMWKLITGP-EDAPDQPQDLDIVFEKGLPVKLTYKDA 239
D N+ HISYE+GILEDPN P +++++ P AP P L I F++GLP + +D
Sbjct: 181 DANILHISYESGILEDPNTVAPENLYEMTVDPLTRAPRDPVHLVIQFDRGLPSSV--EDL 238
Query: 240 ASGKETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVD 299
G+ T PL++ KL + G+GRIDIVENR++ LKSRG YE ++L AH D
Sbjct: 239 PGGR--VYTKPLEMLDFLNKLGGSYGIGRIDIVENRFVGLKSRGVYETPGGTILFAAHQD 296
Query: 300 LEGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYK 359
LE LD+EV + Q + + +YNG +F+PE Y R I+ ++ V+G V + L
Sbjct: 297 LEVFALDREVLRTK-QVLRDRMADYVYNGFWFSPEAIYARKCIELAEQRVSGKVTVELAP 355
Query: 360 GNIIVLGRYS--ETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
G + R + + LYN SMD+ G+ P D GFIAI A+R++++
Sbjct: 356 GYCRAIARKAAKDVGALYNEQLVSMDVHGGYVPQDAGGFIAINAVRIREH 405
>Hs17458794 [E] KOG1706 Argininosuccinate synthase
Length = 433
Score = 306 bits (784), Expect = 4e-83
Identities = 172/407 (42%), Positives = 244/407 (59%), Gaps = 19/407 (4%)
Query: 2 SKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLV 61
SKG + LA SG LDT IL WL EQGY+V+A++A++GQ+EDF+ A KKAL GA K ++
Sbjct: 3 SKGSIVLACSGSLDTFCILVWLKEQGYDVIAYLASIGQKEDFQEARKKALKPGAKKMLIE 62
Query: 62 DCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKG 121
D EFV++ ++PA+Q + +YED YLLGTSLARP I Q++VA++EG VSHG TGKG
Sbjct: 63 DVNREFVEEFIWPAMQSSTLYEDRYLLGTSLARPCITHKQVEVAQREGAKYVSHGTTGKG 122
Query: 122 NDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTD 181
NDQ+ FEL Y+L P K P F++RF G DL YA ++ IP T PWS D
Sbjct: 123 NDQVWFELTCYSLAPTDKGHCSLNMPEFYNRFKGHSDLTEYAKQRGIPTPVTPKNPWSMD 182
Query: 182 ENLAHISYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDAA 240
ENL HIS EAGILE+P P ++ P P+ P L+I F+KG+PVK+T KD+A
Sbjct: 183 ENLMHISCEAGILENPENQAPPALYTKTQDPAKTPNTPDILEIEFKKGVPVKVTNVKDSA 242
Query: 241 SGKETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDL 300
T + L++F+ ++A + VG I IVENR+I KSRG Y ++L AH+D+
Sbjct: 243 -----THQTSLELFMYLNEVAGKHSVGNIAIVENRFIGTKSRGIYRAPAGTILCYAHLDI 297
Query: 301 EGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKG 360
E T+ +EV ++ Q ++ L+Y G + + + S S +
Sbjct: 298 EAFTMYREVHKIK-QCRGLKFAELVYTGFWLSGTALSVNLSATASPSP----------RS 346
Query: 361 NIIVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
+ +LG E +YN + SM++ ++P D TGFI I ++R+K+Y
Sbjct: 347 QVYILG--WECPTVYNEEPVSMNVQGDYEPIDATGFININSLRLKEY 391
>Hs20545296 [E] KOG1706 Argininosuccinate synthase
Length = 396
Score = 298 bits (762), Expect = 1e-80
Identities = 171/408 (41%), Positives = 248/408 (59%), Gaps = 26/408 (6%)
Query: 2 SKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLV 61
+KG V LAYSG LDTS L WL EQGY+V+A++AN+GQ+EDFE A K AL GA K +
Sbjct: 3 TKGSVVLAYSGSLDTSCTLLWLKEQGYDVIAYLANIGQKEDFEEARKNALKFGAKKVFIE 62
Query: 62 DCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKG 121
D EFV++ ++PA+Q +A+YED YLLGTS R + + Q + G V G
Sbjct: 63 DVGREFVEEFIWPAIQSSALYEDRYLLGTS--RQALHRLQTN-----GNHPVEGGQVYVP 115
Query: 122 NDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTD 181
++E P +KVIAPWR P F+++ GR DL+ YA + IP+ T WS D
Sbjct: 116 QHHGKWEQS----APQIKVIAPWRMPKFYNQLKGRNDLMEYAKQHRIPIPVTPKNSWSMD 171
Query: 182 ENLAHISYEAGILEDP-NQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDA 239
ENL HISYE+GILE+P NQ PP+ P AP+ P L+I F+KG+PVK+T KD
Sbjct: 172 ENLMHISYESGILENPKNQAPPDQ------DPAKAPNTPDILEIEFKKGVPVKVTNVKDG 225
Query: 240 ASGKETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVD 299
TT + L++F+ ++ GVG IDI+ENR+I +KSRG Y+ ++L AH+D
Sbjct: 226 -----TTHQTSLELFMYLNEVVGKQGVGCIDIMENRFIGMKSRGIYQAPASTILYLAHLD 280
Query: 300 LEGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYK 359
+ T+ +EVR ++ Q + + L+ G +++PECE++ I SQ V G V++ + +
Sbjct: 281 TKAFTMGQEVRKIK-QGLGLKFVELVDTGFWYSPECEFVCHCIAKSQEQVEGKVQVSVLE 339
Query: 360 GNIIVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
G + +LG+ S +LY + SM++ +Q D TGFI I ++R+K+Y
Sbjct: 340 GQVYILGQESPL-SLYKEEPVSMNVQGDYQSIDATGFININSLRLKEY 386
>Hs20539742 [E] KOG1706 Argininosuccinate synthase
Length = 425
Score = 291 bits (745), Expect = 1e-78
Identities = 168/407 (41%), Positives = 234/407 (57%), Gaps = 44/407 (10%)
Query: 2 SKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLV 61
SKG V LAYSGGLDTS IL WL EQGY+V A++AN+GQ+EDFE A KKA +G K
Sbjct: 52 SKGSVVLAYSGGLDTSCILVWLKEQGYDVTAYLANIGQKEDFEEARKKAPKLGTKKVFTE 111
Query: 62 DCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKG 121
EFV++ ++PA+Q +++YED YLLGTS RP A+ QI
Sbjct: 112 GVSREFVEEFIWPAIQSSSLYEDGYLLGTSHTRPCTARKQI------------------- 152
Query: 122 NDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTD 181
KVIAPW P F++ F G DL Y + IP+ T PW+ D
Sbjct: 153 -----------------KVIAPWSMPEFYNHFKGCSDLTEYTKQHGIPIPVTPKNPWNMD 195
Query: 182 ENLAHISYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDAA 240
ENL HISYEAGILEDP + + G AP+ P L+I F+KG+ +K+T KD
Sbjct: 196 ENLMHISYEAGILEDPQEPSASRSLPEDPGLAKAPNTPDILEIEFKKGVFLKVTNVKDG- 254
Query: 241 SGKETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDL 300
TT + L +F+ ++ + VGRIDIVEN +I +KSRG YE ++L AH+D+
Sbjct: 255 ----TTHQTSLALFMYLNEVTGKHCVGRIDIVENCFIGMKSRGIYETPAGTILYHAHLDI 310
Query: 301 EGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKG 360
E T+D EVR ++ Q + + L+Y G + +PECE++R I SQ V V++ L+K
Sbjct: 311 ETFTMDWEVRKIK-QGLGLKCAELVYTGFWHSPECEFVRHSIAKSQERVERKVQVSLFKD 369
Query: 361 NIIVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
+ +LG + +LYN + SM++ ++P D TGFI I ++R+K+Y
Sbjct: 370 QVYILG-WESPRSLYNEELVSMNVHGDYEPIDATGFININSLRLKEY 415
>At4g24830 [E] KOG1706 Argininosuccinate synthase
Length = 498
Score = 278 bits (711), Expect = 1e-74
Identities = 166/403 (41%), Positives = 230/403 (56%), Gaps = 42/403 (10%)
Query: 5 KVCLAYSGGLDTSVILAWLLEQ-GYEVVAFMANVGQE-EDFEAAEKKALLIGATKFVLVD 62
KV LAYSGGLDTSVI+ WL E G EVV F A+VGQ ++ E E+KA GA++ V+ D
Sbjct: 127 KVVLAYSGGLDTSVIVPWLKENYGCEVVCFTADVGQGIKELEGLEQKAKASGASQLVVKD 186
Query: 63 CREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKGN 122
EEFVKD +FP ++ A+YE YLLGTS+ARPVIAK
Sbjct: 187 LTEEFVKDFIFPCLRAGAIYERKYLLGTSMARPVIAK----------------------- 223
Query: 123 DQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTDE 182
+RFEL F++L P++KV+APWR+ GR+D + YA + N+PV T +S D
Sbjct: 224 --VRFELTFFSLNPELKVVAPWREW----EIQGREDAIEYAKKHNVPVPVTKKSIYSRDR 277
Query: 183 NLAHISYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLTYKDAASG 242
NL H+S+E +LEDP P DM+ + PEDAPDQP+ ++I E GLPV L K
Sbjct: 278 NLWHLSHEGDLLEDPANEPKKDMYMMSVDPEDAPDQPEYIEIGIESGLPVALNGK----- 332
Query: 243 KETTATSPLDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDLEG 302
A SP + + +G+GRID+VENR + +KSRG YE ++L A +LE
Sbjct: 333 ----ALSPATLLAELNTIGGKHGIGRIDMVENRLVGMKSRGVYETPGGTILFAAVQELES 388
Query: 303 LTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKGNI 362
LTLD+E ++D Y+ ++Y G +F P E + + ++ T G+V L+LYKG++
Sbjct: 389 LTLDRESIQVKDTLAL-KYAEMVYAGRWFDPLRESMDAFMEKITETTTGSVTLKLYKGSV 447
Query: 363 IVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVK 405
V GR S +LY D SS + + D GFI + + +K
Sbjct: 448 SVTGRQS-PNSLYRQDISSFEGSEIYNQADAAGFIRLYGLPMK 489
>Hs18602887 [E] KOG1706 Argininosuccinate synthase
Length = 339
Score = 208 bits (530), Expect = 1e-53
Identities = 116/267 (43%), Positives = 159/267 (59%), Gaps = 30/267 (11%)
Query: 2 SKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLV 61
SKG + LAYSGGL+TS IL WL EQGY+V A++AN GQ+EDFE A KKAL +GA K +
Sbjct: 3 SKGSMVLAYSGGLNTSCILVWLKEQGYDVTAYLANTGQKEDFEEARKKALKLGAKKVFIE 62
Query: 62 DCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKG 121
D EFV++ ++ A+Q +A+YED YLLGTSL RP IA +++ ++ G
Sbjct: 63 DVSREFVEEFIWAAIQSSALYEDHYLLGTSLTRPCIAHKKVETVQRVGA----------- 111
Query: 122 NDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTD 181
K + APWR P F++ F GR DL+ YA + IP+ T WS D
Sbjct: 112 -------------KYEGPWRAPWRMPEFYNWFKGRSDLMEYAKQHGIPILVTPKNLWSID 158
Query: 182 ENLAHISYEAGILEDPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDAA 240
+NL HISY+AGILE+P P ++ I P AP+ P L I F+KG+PV++T KD
Sbjct: 159 KNLMHISYKAGILENPKNQVPPGLYTKIQDPAKAPNTPDILKIQFKKGVPVRVTSVKDG- 217
Query: 241 SGKETTATSPLDIFLTSAKLARANGVG 267
TT + L++F+ ++A +GVG
Sbjct: 218 ----TTHQTSLELFMYLNEVAGKHGVG 240
Score = 61.2 bits (147), Expect = 3e-09
Identities = 28/76 (36%), Positives = 48/76 (62%), Gaps = 1/76 (1%)
Query: 332 TPECEYIRSMIQPSQSTVNGTVRLRLYKGNIIVLGRYSETENLYNPDESSMDILTGFQPT 391
+PECE++R I SQ G V++ + KG + +LG + +LYN + S+++ ++P
Sbjct: 255 SPECEFVRPCIAKSQEPAEGKVQVPVLKGQVYILG-WESPLSLYNEELMSVNVQGDYEPI 313
Query: 392 DTTGFIAIQAIRVKKY 407
D TGFI I ++R+K+Y
Sbjct: 314 DDTGFININSLRLKEY 329
>Hs17468745 [E] KOG1706 Argininosuccinate synthase
Length = 264
Score = 152 bits (385), Expect = 7e-37
Identities = 85/181 (46%), Positives = 112/181 (60%), Gaps = 12/181 (6%)
Query: 2 SKGKVCLAYSGGLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLV 61
SKG V LAYSG DTS IL WL EQGY+++A++AN GQ+EDFE A KKAL +G K +
Sbjct: 20 SKGSVVLAYSGSPDTSCILVWLKEQGYDIIAYLANTGQKEDFEEAWKKALKLGTKKVFIE 79
Query: 62 DCREEFVKDVLFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKG 121
D EFV++ ++PA+Q +A+YE+ YLLGTSLARP IA Q+++AKQE V HG TGKG
Sbjct: 80 DASREFVEEFIWPAIQSSALYENRYLLGTSLARPGIAGKQVEIAKQEEAKYVFHGTTGKG 139
Query: 122 NDQIRFELGFYALKPDVKVIAPWRDPTFFDRFAGRKDLLAYAAEKNIPVFQTASKPWSTD 181
NDQ + G Y +DP + D+L +K +PV T K +T
Sbjct: 140 NDQNQVPPGLY---------MKTQDPA---KALNTPDILEIKFKKGVPVKVTNVKDGTTH 187
Query: 182 E 182
+
Sbjct: 188 Q 188
Score = 67.8 bits (164), Expect = 3e-11
Identities = 46/152 (30%), Positives = 78/152 (51%), Gaps = 30/152 (19%)
Query: 196 DPNQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDAASGKETTATSPLDIF 254
D NQ PP ++ P A + P L+I F+KG+PVK+T KD TT + L++F
Sbjct: 141 DQNQVPPG-LYMKTQDPAKALNTPDILEIKFKKGVPVKVTNVKDG-----TTHQTSLELF 194
Query: 255 LTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDLEGLTLDKEVRALRD 314
+ ++A +GVGR ++L H+D++ T+ +EVR ++
Sbjct: 195 VYLNEVAGKHGVGR----------------------TILHHTHLDIKAFTMYREVRKIK- 231
Query: 315 QFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQ 346
Q ++ ++ L+Y G + +PECE++R SQ
Sbjct: 232 QGLSLKFAELVYTGFWHSPECEFVRHCNAKSQ 263
>Hs18573672 [E] KOG1706 Argininosuccinate synthase
Length = 303
Score = 124 bits (312), Expect = 2e-28
Identities = 61/111 (54%), Positives = 80/111 (71%)
Query: 13 GLDTSVILAWLLEQGYEVVAFMANVGQEEDFEAAEKKALLIGATKFVLVDCREEFVKDVL 72
GLDTS IL W EQGY+++A++AN+GQ+EDFE A KKAL +GA K + D EFV++ +
Sbjct: 25 GLDTSCILMWPKEQGYDIIAYLANIGQKEDFEEARKKALKLGAKKVFIEDASREFVEEFI 84
Query: 73 FPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKGND 123
+PA+Q A+YED LLGTSLARP IA Q+++ +QEG VSHG K D
Sbjct: 85 WPAIQSRALYEDHCLLGTSLARPCIACKQMEIVQQEGAKYVSHGLYTKTQD 135
Score = 62.4 bits (150), Expect = 1e-09
Identities = 33/109 (30%), Positives = 61/109 (55%), Gaps = 2/109 (1%)
Query: 299 DLEGLTLDKEVRALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLY 358
D++ T+D EVR ++ Q + ++ L+Y G + PECE++R I Q V G V++ +
Sbjct: 187 DIKAFTMDLEVRKIK-QGLGLEFAELVYTGFWHRPECEFVRHCIAKFQERVEGKVQVSVL 245
Query: 359 KGNIIVLGRYSETENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
KG + +L + +LY+ SM + ++P D FI I ++ +++Y
Sbjct: 246 KGQVYILS-WEYALSLYSQLLVSMKVQDDYEPIDAIRFININSLTLREY 293
>Hs22043876 [E] KOG1706 Argininosuccinate synthase
Length = 341
Score = 115 bits (287), Expect = 2e-25
Identities = 72/211 (34%), Positives = 116/211 (54%), Gaps = 30/211 (14%)
Query: 198 NQTPPNDMWKLITGPEDAPDQPQDLDIVFEKGLPVKLT-YKDAASGKETTATSPLDIFLT 256
NQ PP ++ +AP+ P+ L+I F+KG+PVK+T KD TT + L++F+
Sbjct: 40 NQPPPG-LYMKTQDLANAPNAPEILEIEFKKGVPVKMTNVKDG-----TTHQTSLELFVY 93
Query: 257 SAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDLEGLTLDKEVRALRDQF 316
+++ + VGR DIVENR I +KSRG YE ++L ++D++ T+D E
Sbjct: 94 LSQVTGKHSVGRTDIVENRCIRMKSRGIYETPAGTILYHTYLDIKVFTMDWE-------- 145
Query: 317 VTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKGNIIVLGRYSETENLYN 376
+PECE+ I SQ V G V++ + KG + +L R S +LYN
Sbjct: 146 --------------HSPECEFAHHCIAKSQERVEGKVQVSVLKGQVYILSRESPL-SLYN 190
Query: 377 PDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
+ SM++ ++P D+TGFI I ++++K+Y
Sbjct: 191 KELVSMNMQGDYEPIDSTGFININSLKLKEY 221
>Hs17452937 [E] KOG1706 Argininosuccinate synthase
Length = 155
Score = 87.4 bits (215), Expect = 4e-17
Identities = 48/157 (30%), Positives = 88/157 (55%), Gaps = 20/157 (12%)
Query: 251 LDIFLTSAKLARANGVGRIDIVENRYINLKSRGCYEQAPLSVLRRAHVDLEGLTLDKEVR 310
L++F+ ++ +G+G IDI+EN +I +KSRG Y+ ++L++A +D+E T+D+EV
Sbjct: 9 LELFVYLNEVTGKHGMGCIDIMENCFIRIKSRGIYKTPAGTILQQADLDIEDFTMDREVH 68
Query: 311 ALRDQFVTPNYSRLLYNGSYFTPECEYIRSMIQPSQSTVNGTVRLRLYKGNIIVLGRYSE 370
+ PEC+ + I SQ + G V++ ++KG + +L + S
Sbjct: 69 KI-------------------NPECKSVHHCITKSQEQMEGKVQVPIFKGQVHILSQES- 108
Query: 371 TENLYNPDESSMDILTGFQPTDTTGFIAIQAIRVKKY 407
+LY + S+++ ++P D TGFI I +R+K+Y
Sbjct: 109 LLSLYKEELVSVNVQGNYEPIDATGFININYLRLKEY 145
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.136 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,362,619
Number of Sequences: 60738
Number of extensions: 1110038
Number of successful extensions: 2292
Number of sequences better than 1.0e-05: 14
Number of HSP's better than 0.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2237
Number of HSP's gapped (non-prelim): 20
length of query: 420
length of database: 30,389,216
effective HSP length: 109
effective length of query: 311
effective length of database: 23,768,774
effective search space: 7392088714
effective search space used: 7392088714
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)