ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1088 check: MH T KOG0198 Signal transduction mechanisms MEKK and related serine/threonine protein kinases
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1088 384198 386588 797
(797 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 439 e-122
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 227 5e-59
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 222 2e-57
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 221 3e-57
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 182 2e-45
At3g15220 [T] KOG0201 Serine/threonine protein kinase 180 9e-45
At1g53165 [T] KOG0201 Serine/threonine protein kinase 178 3e-44
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 177 7e-44
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 176 2e-43
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 174 6e-43
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 173 1e-42
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 172 1e-42
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 172 2e-42
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 172 2e-42
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 171 3e-42
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 171 5e-42
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 171 5e-42
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 170 7e-42
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 170 7e-42
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 170 9e-42
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 169 1e-41
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 169 1e-41
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 169 2e-41
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 169 2e-41
7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 169 2e-41
YHR102w [T] KOG0201 Serine/threonine protein kinase 167 4e-41
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 167 4e-41
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 167 4e-41
CE28674 [T] KOG0201 Serine/threonine protein kinase 167 4e-41
CE07510 [T] KOG0201 Serine/threonine protein kinase 167 4e-41
7300224 [T] KOG0201 Serine/threonine protein kinase 167 6e-41
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 167 8e-41
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 167 8e-41
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 167 8e-41
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 167 8e-41
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 166 1e-40
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 165 3e-40
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 164 4e-40
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 164 5e-40
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 161 3e-39
Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase k... 161 3e-39
Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase k... 161 3e-39
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 161 4e-39
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 160 5e-39
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 160 7e-39
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 159 1e-38
SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protei... 159 2e-38
7300559 [T] KOG4279 Serine/threonine protein kinase 159 2e-38
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 158 3e-38
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 157 5e-38
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 157 5e-38
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 157 5e-38
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 157 6e-38
Hs4758702 [T] KOG4279 Serine/threonine protein kinase 157 6e-38
At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protei... 157 6e-38
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 156 1e-37
7293601 [T] KOG0577 Serine/threonine protein kinase 155 2e-37
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 155 3e-37
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 155 3e-37
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 154 4e-37
YDR523c [T] KOG0201 Serine/threonine protein kinase 154 7e-37
At4g08470 [T] KOG0198 MEKK and related serine/threonine protein ... 153 9e-37
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 153 9e-37
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 153 1e-36
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 153 1e-36
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 153 1e-36
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 153 1e-36
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 153 1e-36
Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 152 1e-36
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 152 2e-36
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 152 2e-36
CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 151 3e-36
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 150 7e-36
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 150 7e-36
YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 149 2e-35
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 149 2e-35
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 149 2e-35
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 149 2e-35
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 148 3e-35
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 147 5e-35
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 147 6e-35
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 147 6e-35
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 147 6e-35
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 147 6e-35
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 146 1e-34
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 146 1e-34
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 146 1e-34
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 146 1e-34
CE27177 [T] KOG4279 Serine/threonine protein kinase 146 1e-34
ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase 145 2e-34
At4g08480 [T] KOG0198 MEKK and related serine/threonine protein ... 145 3e-34
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 145 3e-34
YLR362w [T] KOG0198 MEKK and related serine/threonine protein ki... 144 5e-34
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 144 5e-34
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 143 9e-34
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 143 1e-33
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 143 1e-33
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 142 2e-33
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 142 2e-33
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 142 3e-33
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 142 3e-33
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 142 3e-33
At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase 141 3e-33
CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase 140 1e-32
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 139 1e-32
At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase 139 2e-32
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 139 2e-32
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 139 2e-32
CE01405 [T] KOG0577 Serine/threonine protein kinase 137 8e-32
At2g45490 [D] KOG0580 Serine/threonine protein kinase 137 8e-32
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 137 8e-32
Hs21361643 [T] KOG4717 Serine/threonine protein kinase 136 1e-31
7302570 [R] KOG0586 Serine/threonine protein kinase 136 1e-31
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 135 2e-31
At4g26890 [T] KOG0198 MEKK and related serine/threonine protein ... 135 2e-31
At4g18700 [T] KOG0583 Serine/threonine protein kinase 135 2e-31
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 135 3e-31
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 135 3e-31
At2g32510 [T] KOG0198 MEKK and related serine/threonine protein ... 135 3e-31
7303211 [T] KOG4717 Serine/threonine protein kinase 134 4e-31
7290249 [R] KOG0586 Serine/threonine protein kinase 134 5e-31
Hs18602554 [T] KOG0578 p21-activated serine/threonine protein ki... 134 7e-31
At4g32830 [D] KOG0580 Serine/threonine protein kinase 134 7e-31
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 134 7e-31
At2g26980 [T] KOG0583 Serine/threonine protein kinase 133 9e-31
7299536 [D] KOG0580 Serine/threonine protein kinase 133 9e-31
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 132 2e-30
At1g29230 [T] KOG0583 Serine/threonine protein kinase 132 2e-30
7293666 [D] KOG0575 Polo-like serine/threonine protein kinase 132 2e-30
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 131 4e-30
Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase 131 4e-30
7299438 [R] KOG0586 Serine/threonine protein kinase 131 4e-30
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 131 5e-30
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 131 5e-30
CE28479 [T] KOG0583 Serine/threonine protein kinase 131 5e-30
7304283 [Z] KOG0613 Projectin/twitchin and related proteins 131 5e-30
7293761 [T] KOG4721 Serine/threonine protein kinase contains leu... 130 6e-30
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 130 8e-30
At1g01140 [T] KOG0583 Serine/threonine protein kinase 130 8e-30
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 130 1e-29
7302464 [R] KOG0586 Serine/threonine protein kinase 130 1e-29
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 129 1e-29
Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase 129 1e-29
CE27573 [T] KOG0198 MEKK and related serine/threonine protein ki... 129 1e-29
CE07737 [T] KOG0198 MEKK and related serine/threonine protein ki... 129 1e-29
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 129 1e-29
7299437 [R] KOG0586 Serine/threonine protein kinase 129 1e-29
CE27768 [R] KOG0586 Serine/threonine protein kinase 129 2e-29
CE23838 [R] KOG0586 Serine/threonine protein kinase 129 2e-29
CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase 129 2e-29
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 128 3e-29
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 128 3e-29
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 128 3e-29
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 128 3e-29
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 128 3e-29
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 128 3e-29
At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase 128 3e-29
HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains ... 128 4e-29
Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains ... 128 4e-29
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 127 5e-29
CE17284 [T] KOG0583 Serine/threonine protein kinase 127 5e-29
At2g34180 [T] KOG0583 Serine/threonine protein kinase 127 5e-29
Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains l... 127 7e-29
At5g55090 [T] KOG0198 MEKK and related serine/threonine protein ... 127 7e-29
At3g29160 [T] KOG0583 Serine/threonine protein kinase 127 7e-29
At1g48260 [T] KOG0583 Serine/threonine protein kinase 127 7e-29
At1g07150 [T] KOG0198 MEKK and related serine/threonine protein ... 127 7e-29
7303915 [T] KOG0694 Serine/threonine protein kinase 127 7e-29
7303914 [T] KOG0694 Serine/threonine protein kinase 127 7e-29
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 127 9e-29
7295426 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 127 9e-29
YPL209c [D] KOG0580 Serine/threonine protein kinase 126 1e-28
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 126 1e-28
At4g24400 [T] KOG0583 Serine/threonine protein kinase 126 1e-28
At2g30360 [T] KOG0583 Serine/threonine protein kinase 126 1e-28
At1g30270 [T] KOG0583 Serine/threonine protein kinase 126 1e-28
Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 125 2e-28
CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase 125 2e-28
At5g45820 [T] KOG0583 Serine/threonine protein kinase 125 2e-28
YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 125 3e-28
Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 125 3e-28
At2g25880 [D] KOG0580 Serine/threonine protein kinase 125 3e-28
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 125 3e-28
Hs4502557 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 125 3e-28
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 125 3e-28
HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase 124 4e-28
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 124 4e-28
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 124 4e-28
At3g01090 [T] KOG0583 Serine/threonine protein kinase 124 6e-28
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 124 6e-28
Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 124 7e-28
CE28643 [T] KOG0583 Serine/threonine protein kinase 124 7e-28
CE07458 [T] KOG0583 Serine/threonine protein kinase 124 7e-28
At5g45810 [T] KOG0583 Serine/threonine protein kinase 124 7e-28
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 123 1e-27
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 123 1e-27
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 123 1e-27
At4g30960 [T] KOG0583 Serine/threonine protein kinase 123 1e-27
At5g07070 [T] KOG0583 Serine/threonine protein kinase 123 1e-27
At2g31500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 123 1e-27
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 122 2e-27
Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 122 2e-27
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 122 2e-27
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 122 2e-27
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 122 2e-27
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 122 2e-27
CE09360 [Z] KOG0613 Projectin/twitchin and related proteins 122 3e-27
At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 122 3e-27
At1g76040 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 122 3e-27
7304358 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 122 3e-27
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 121 4e-27
Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 121 4e-27
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 121 4e-27
At1g05100 [T] KOG0198 MEKK and related serine/threonine protein ... 121 4e-27
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 121 5e-27
CE24761 [D] KOG0580 Serine/threonine protein kinase 121 5e-27
7290150 [T] KOG0583 Serine/threonine protein kinase 121 5e-27
YFR014c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 120 6e-27
Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase 120 6e-27
CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase 120 6e-27
At5g25110 [T] KOG0583 Serine/threonine protein kinase 120 6e-27
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 120 6e-27
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 120 8e-27
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 120 8e-27
CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 120 8e-27
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 120 8e-27
YKL101w [D] KOG0588 Serine/threonine protein kinase 120 1e-26
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 120 1e-26
Hs20127418 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 120 1e-26
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 120 1e-26
Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 120 1e-26
At3g20860 [R] KOG0589 Serine/threonine protein kinase 120 1e-26
YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 119 1e-26
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 119 1e-26
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 119 1e-26
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 119 1e-26
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 119 2e-26
Hs21361133 [R] KOG0586 Serine/threonine protein kinase 119 2e-26
CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 119 2e-26
At5g01810 [T] KOG0583 Serine/threonine protein kinase 119 2e-26
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 119 2e-26
CE21025 [D] KOG0580 Serine/threonine protein kinase 119 2e-26
CE00847 [T] KOG0583 Serine/threonine protein kinase 119 2e-26
At5g58380 [T] KOG0583 Serine/threonine protein kinase 119 2e-26
At1g32320 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 119 2e-26
CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 118 3e-26
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 118 3e-26
At2g25090 [T] KOG0583 Serine/threonine protein kinase 118 3e-26
CE17429 [T] KOG0194 Protein tyrosine kinase 118 4e-26
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 118 4e-26
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 118 4e-26
7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 118 4e-26
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 117 5e-26
At5g39440 [T] KOG0583 Serine/threonine protein kinase 117 5e-26
At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GT... 117 5e-26
SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kina... 117 7e-26
Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 117 7e-26
Hs14770402 [R] KOG0586 Serine/threonine protein kinase 117 7e-26
At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase 117 7e-26
YCL024w [T] KOG0583 Serine/threonine protein kinase 117 9e-26
Hs22065797 [T] KOG0577 Serine/threonine protein kinase 117 9e-26
CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 117 9e-26
At3g17510 [T] KOG0583 Serine/threonine protein kinase 117 9e-26
At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 117 9e-26
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 117 9e-26
At1g50700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 117 9e-26
7302861 [T] KOG0696 Serine/threonine protein kinase 117 9e-26
7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 117 9e-26
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 117 9e-26
YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 116 1e-25
Hs6005850 [D] KOG0615 Serine/threonine protein kinase Chk2 and r... 116 1e-25
Hs16507245 [T] KOG0583 Serine/threonine protein kinase 116 1e-25
CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
CE28051 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 116 1e-25
At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 116 1e-25
Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases 116 2e-25
7297009 [R] KOG0593 Predicted protein kinase KKIAMRE 116 2e-25
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 115 2e-25
At5g35410 [T] KOG0583 Serine/threonine protein kinase 115 2e-25
At3g10540 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 115 2e-25
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 115 2e-25
7300106 [T] KOG0690 Serine/threonine protein kinase 115 2e-25
7297776 [D] KOG0580 Serine/threonine protein kinase 115 2e-25
Hs7706286 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase E... 115 3e-25
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 115 3e-25
Hs17933758 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 115 3e-25
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 115 3e-25
Hs14042947 [T] KOG0583 Serine/threonine protein kinase 115 3e-25
CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 115 3e-25
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 115 3e-25
At4g04740 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 115 3e-25
At3g20410 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 115 3e-25
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 115 3e-25
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 115 3e-25
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 115 3e-25
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 115 3e-25
CE21086 [D] KOG0590 Checkpoint kinase and related serine/threoni... 115 3e-25
CE20258 [R] KOG0593 Predicted protein kinase KKIAMRE 115 3e-25
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 115 3e-25
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 115 3e-25
At4g04720 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 115 3e-25
At3g23000 [T] KOG0583 Serine/threonine protein kinase 115 3e-25
At1g54510 [R] KOG0589 Serine/threonine protein kinase 115 3e-25
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 115 3e-25
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 115 3e-25
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 114 5e-25
At5g10930 [T] KOG0583 Serine/threonine protein kinase 114 5e-25
At3g06640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 114 5e-25
At2g35890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 114 5e-25
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 114 6e-25
Hs4757868 [T] KOG0193 Serine/threonine protein kinase RAF 114 6e-25
Hs20143922 [Z] KOG0613 Projectin/twitchin and related proteins 114 6e-25
Hs20143918 [Z] KOG0613 Projectin/twitchin and related proteins 114 6e-25
Hs20143914 [Z] KOG0613 Projectin/twitchin and related proteins 114 6e-25
Hs19747267 [Z] KOG0613 Projectin/twitchin and related proteins 114 6e-25
Hs17455844 [TR] KOG0606 Microtubule-associated serine/threonine ... 114 6e-25
At3g06630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 114 6e-25
At1g73660 [T] KOG0192 Tyrosine kinase specific for activated (GT... 114 6e-25
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 114 8e-25
Hs14141724 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 114 8e-25
At3g50310 [T] KOG0198 MEKK and related serine/threonine protein ... 114 8e-25
7290903 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 114 8e-25
7290147 [T] KOG0583 Serine/threonine protein kinase 114 8e-25
SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase 113 1e-24
Hs7706601 [T] KOG0192 Tyrosine kinase specific for activated (GT... 113 1e-24
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 113 1e-24
Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PK... 113 1e-24
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 113 1e-24
Hs19526767 [T] KOG0192 Tyrosine kinase specific for activated (G... 113 1e-24
Hs14150045 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 113 1e-24
CE29092 [T] KOG0694 Serine/threonine protein kinase 113 1e-24
CE20493 [TR] KOG0606 Microtubule-associated serine/threonine kin... 113 1e-24
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 113 1e-24
At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GT... 113 1e-24
YDR507c [D] KOG0588 Serine/threonine protein kinase 113 1e-24
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 113 1e-24
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 113 1e-24
CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 113 1e-24
CE04603 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 113 1e-24
At5g57630 [T] KOG0583 Serine/threonine protein kinase 113 1e-24
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 112 2e-24
Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 112 2e-24
Hs22043888 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 112 2e-24
Hs20536136 [T] KOG0192 Tyrosine kinase specific for activated (G... 112 2e-24
CE02291 [T] KOG0194 Protein tyrosine kinase 112 2e-24
At1g60940 [T] KOG0583 Serine/threonine protein kinase 112 2e-24
7301213 [R] KOG0589 Serine/threonine protein kinase 112 2e-24
7294217 [D] KOG0588 Serine/threonine protein kinase 112 2e-24
SPCC24B10.07 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 112 2e-24
Hs4507271 [T] KOG0583 Serine/threonine protein kinase 112 2e-24
CE17354 [T] KOG0694 Serine/threonine protein kinase 112 2e-24
CE17353 [T] KOG0694 Serine/threonine protein kinase 112 2e-24
CE06635 [Z] KOG0613 Projectin/twitchin and related proteins 112 2e-24
CE06634 [Z] KOG0613 Projectin/twitchin and related proteins 112 2e-24
At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GT... 112 2e-24
7296128 [T] KOG0583 Serine/threonine protein kinase 112 2e-24
Hs4507361 [T] KOG0192 Tyrosine kinase specific for activated (GT... 112 3e-24
Hs21735566 [T] KOG0192 Tyrosine kinase specific for activated (G... 112 3e-24
Hs21735564 [T] KOG0192 Tyrosine kinase specific for activated (G... 112 3e-24
Hs21735562 [T] KOG0192 Tyrosine kinase specific for activated (G... 112 3e-24
Hs16950621 [Z] KOG0613 Projectin/twitchin and related proteins 112 3e-24
Hs16950613 [Z] KOG0613 Projectin/twitchin and related proteins 112 3e-24
Hs16950611 [Z] KOG0613 Projectin/twitchin and related proteins 112 3e-24
Hs16950601 [Z] KOG0613 Projectin/twitchin and related proteins 112 3e-24
At4g33950 [T] KOG0583 Serine/threonine protein kinase 112 3e-24
At3g04810 [R] KOG0589 Serine/threonine protein kinase 112 3e-24
7298323 [D] KOG0590 Checkpoint kinase and related serine/threoni... 112 3e-24
7291710 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 112 3e-24
Hs14916455 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 111 4e-24
At5g01820 [T] KOG0583 Serine/threonine protein kinase 111 4e-24
At2g30040 [T] KOG0198 MEKK and related serine/threonine protein ... 111 4e-24
7301110 [T] KOG0660 Mitogen-activated protein kinase 111 4e-24
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 111 5e-24
YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 111 5e-24
HsM8923212 [T] KOG4717 Serine/threonine protein kinase 111 5e-24
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 111 5e-24
Hs22057171 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 111 5e-24
CE18699 [T] KOG0694 Serine/threonine protein kinase 111 5e-24
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 111 5e-24
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 111 5e-24
At1g78290 [T] KOG0583 Serine/threonine protein kinase 111 5e-24
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 110 7e-24
Hs4502731 [R] KOG0663 Protein kinase PITSLRE and related kinases 110 7e-24
Hs16950647 [R] KOG0663 Protein kinase PITSLRE and related kinases 110 7e-24
At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 110 7e-24
At1g10940 [T] KOG0583 Serine/threonine protein kinase 110 7e-24
Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 110 7e-24
YDR477w [T] KOG0583 Serine/threonine protein kinase 110 9e-24
HsM4505263 [T] KOG0192 Tyrosine kinase specific for activated (G... 110 9e-24
Hs5453976 [T] KOG0694 Serine/threonine protein kinase 110 9e-24
Hs21735550 [T] KOG0192 Tyrosine kinase specific for activated (G... 110 9e-24
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 110 9e-24
CE18454 [T] KOG4717 Serine/threonine protein kinase 110 9e-24
At4g21940 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 110 9e-24
At1g67890 [T] KOG0192 Tyrosine kinase specific for activated (GT... 110 9e-24
7294265 [TR] KOG0606 Microtubule-associated serine/threonine kin... 110 9e-24
7292679 [G] KOG0599 Phosphorylase kinase gamma subunit 110 9e-24
Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (... 110 1e-23
ECU02g0550 [D] KOG0575 Polo-like serine/threonine protein kinase 110 1e-23
CE18899 [T] KOG0194 Protein tyrosine kinase 110 1e-23
7301734 [T] KOG0694 Serine/threonine protein kinase 110 1e-23
SPCC63.08c [OUT] KOG0595 Serine/threonine-protein kinase involve... 109 1e-23
Hs4885549 [T] KOG0690 Serine/threonine protein kinase 109 1e-23
Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 109 1e-23
Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases 109 1e-23
CE19294 [T] KOG0198 MEKK and related serine/threonine protein ki... 109 1e-23
CE08385 [T] KOG0194 Protein tyrosine kinase 109 1e-23
SPCC297.03 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 109 2e-23
SPBC32C12.03c [T] KOG0583 Serine/threonine protein kinase 109 2e-23
At5g08590 [T] KOG0583 Serine/threonine protein kinase 109 2e-23
At4g14580 [T] KOG0583 Serine/threonine protein kinase 109 2e-23
At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 109 2e-23
Hs4826776 [T] KOG0197 Tyrosine kinases 108 2e-23
Hs4502803 [D] KOG0590 Checkpoint kinase and related serine/threo... 108 2e-23
Hs4502023 [T] KOG0690 Serine/threonine protein kinase 108 2e-23
Hs13384594 [T] KOG0696 Serine/threonine protein kinase 108 2e-23
CE28218 [D] KOG0588 Serine/threonine protein kinase 108 2e-23
CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 108 2e-23
At5g12180 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 2e-23
At4g40010 [T] KOG0583 Serine/threonine protein kinase 108 2e-23
At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GT... 108 2e-23
7295638 [T] KOG0603 Ribosomal protein S6 kinase 108 2e-23
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 108 3e-23
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 108 3e-23
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 108 3e-23
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 108 3e-23
At5g49470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 108 3e-23
At5g11850 [T] KOG0192 Tyrosine kinase specific for activated (GT... 108 3e-23
At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 3e-23
7298087 [T] KOG0660 Mitogen-activated protein kinase 108 3e-23
Hs4758128_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 108 3e-23
SPAC890.03 [T] KOG0583 Serine/threonine protein kinase 108 4e-23
Hs4885061 [T] KOG0690 Serine/threonine protein kinase 108 4e-23
Hs14149671 [TR] KOG0606 Microtubule-associated serine/threonine ... 108 4e-23
Hs13376582 [T] KOG0198 MEKK and related serine/threonine protein... 108 4e-23
At3g57530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 4e-23
At3g19300 [T] KOG1187 Serine/threonine protein kinase 108 4e-23
At2g11520 [T] KOG1187 Serine/threonine protein kinase 108 4e-23
7303019 [Z] KOG0613 Projectin/twitchin and related proteins 108 4e-23
Hs4557439 [R] KOG0594 Protein kinase PCTAIRE and related kinases 107 6e-23
CE21879 [D] KOG0590 Checkpoint kinase and related serine/threoni... 107 6e-23
CE16081 [T] KOG0583 Serine/threonine protein kinase 107 6e-23
CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases 107 6e-23
At5g19450 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 6e-23
At5g19360 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 6e-23
At4g36070 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 6e-23
At1g61950 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 6e-23
7302860 [T] KOG0696 Serine/threonine protein kinase 107 6e-23
Hs8923539 [R] KOG0597 Serine-threonine protein kinase FUSED 107 7e-23
Hs5453978 [T] KOG0614 cGMP-dependent protein kinase 107 7e-23
Hs14670383 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 107 7e-23
CE27166 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 107 7e-23
At5g28290 [R] KOG0589 Serine/threonine protein kinase 107 7e-23
At4g24480 [T] KOG0192 Tyrosine kinase specific for activated (GT... 107 7e-23
At2g38490 [T] KOG0583 Serine/threonine protein kinase 107 7e-23
Hs7019489 [T] KOG0694 Serine/threonine protein kinase 107 9e-23
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 107 9e-23
Hs20543401 [TR] KOG0606 Microtubule-associated serine/threonine ... 107 9e-23
CE03609 [T] KOG0194 Protein tyrosine kinase 107 9e-23
At5g04870 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 107 9e-23
At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase 107 9e-23
At3g48750 [R] KOG0594 Protein kinase PCTAIRE and related kinases 107 9e-23
At3g44200 [R] KOG0589 Serine/threonine protein kinase 107 9e-23
Hs5902140_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 107 9e-23
CE02602_1 [T] KOG0660 Mitogen-activated protein kinase 107 9e-23
Hs4758194 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 106 1e-22
CE23001 [R] KOG0589 Serine/threonine protein kinase 106 1e-22
At3g10660 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 106 1e-22
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 106 1e-22
Hs4502567_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase... 106 1e-22
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 106 2e-22
Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 106 2e-22
At5g66880 [T] KOG0583 Serine/threonine protein kinase 106 2e-22
At3g50500 [T] KOG0583 Serine/threonine protein kinase 106 2e-22
YCR091w [R] KOG0610 Putative serine/threonine protein kinase 105 2e-22
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 105 2e-22
Hs6382058 [T] KOG4278 Protein tyrosine kinase 105 2e-22
Hs4885045 [T] KOG4278 Protein tyrosine kinase 105 2e-22
Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 105 2e-22
Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (... 105 2e-22
At5g67080 [T] KOG0198 MEKK and related serine/threonine protein ... 105 2e-22
At4g36450 [T] KOG0660 Mitogen-activated protein kinase 105 2e-22
At3g18750 [R] KOG0584 Serine/threonine protein kinase 105 2e-22
At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GT... 105 2e-22
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 105 2e-22
7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 105 2e-22
YER129w [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 105 3e-22
Hs4506067 [T] KOG0696 Serine/threonine protein kinase 105 3e-22
Hs16418343 [T] KOG0583 Serine/threonine protein kinase 105 3e-22
CE28168 [T] KOG0194 Protein tyrosine kinase 105 3e-22
CE15235 [R] KOG0589 Serine/threonine protein kinase 105 3e-22
CE02377 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 105 3e-22
At5g39420 [D] KOG0600 Cdc2-related protein kinase 105 3e-22
At3g56760 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 105 3e-22
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 439 bits (1128), Expect = e-122
Identities = 313/923 (33%), Positives = 463/923 (49%), Gaps = 158/923 (17%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y LKQVIGRG+YGVVY+A+ + T++ AIK++ +E++ ELN+ M EI LLKNL H NIV+
Sbjct: 25 YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVK 84
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGP--LLEDDTVNYVTQTLYGLQYLHEQGVIH 127
Y GFI+K++ELYI+LEYCA GSLR ++ L E+++ YVTQTL GL+YLH +GVIH
Sbjct: 85 YHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIH 144
Query: 128 RDIKAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSL 187
RDIKAAN+LL+ + VKLADFGVST +N A+T AG+ NWMAPE++ +GAST+SDIWSL
Sbjct: 145 RDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSL 204
Query: 188 GATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
GATVVE+LT NPP+HNL + + YA+ N+ Y PP + S KDFLS+CF KNM+KR TA
Sbjct: 205 GATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTAD 264
Query: 248 ELLAHIWLKKIQKPK-SKIN--LAEYIEKDGKWDVDFVLDSNTDMTPS------------ 292
+LL H+W+ + K K+N ++ + D WD DF + +++PS
Sbjct: 265 QLLKHVWINSTENVKVDKLNKFKEDFTDADYHWDADF-QEEKLNISPSKFSLRAAPAPWA 323
Query: 293 ----------PTKSPIQEDLAPADFRTLSVDQLFIEHSTDSIVVGLIKTLNELTAIKADA 342
PT+S + L + + LF S ++I +I+ L+ T K
Sbjct: 324 ENNQELDLMPPTESQLLSQLKSSSKPLTDLHVLFSVCSLENIADTIIECLSRTTVDKRLI 383
Query: 343 TASGSLSNRTFEILKYDKQFNHTALKEKFIDNGGTPLLISLRFESVLAAFFEKSVKLLIQ 402
TA GS I YD Q NH+ L+ KFI GG PL+I +FE + F + LI+
Sbjct: 384 TAFGS-------IFVYDTQHNHSRLRLKFIAMGGIPLII--KFEHLAKEFVIDYPQTLIE 434
Query: 403 CGIL--SHFDSLKNSRLTVLVSYCYRTLTSHDIWNQWCLSHKDKISACVNAELTSTKYIE 460
CGI+ +F SLK + + + Y + LTS W +WC H D ++ L +
Sbjct: 435 CGIMYPPNFASLKTPKYILELVYRFYDLTSTAFWCRWCFKHLD-----ISLLLNNIHERR 489
Query: 461 AEKLLIHVSMIK--DFPLSVPKLMLFAKKYK-----HLQHCIFTSLNNSI--------KR 505
A+ +L+ +S F +P L+ K K + + +F S+N I K
Sbjct: 490 AQSILLKLSSYAPWSFEKILPSLIDSKLKKKILISPQITYVVFKSINYMITTNDDKIHKS 549
Query: 506 TI--------------------VNVPTSNLIHGKLFYEK---------SNFP-VTIQE-- 533
I V P+ + +H + SNFP +TI
Sbjct: 550 AIPSSSSLPLSSSPTRNSPVNSVQSPSRSPVHSLMATRPSSPMRHKSISNFPHLTISSKS 609
Query: 534 ------------WLLEMITHVKR----KATDPFVELCFHVCHLNNKSIELLMKDGHFLAL 577
WL + + F +LC+ H+N+ + L+ + F A
Sbjct: 610 RLLIELPEGFFTWLTSFFVDMAQIKDLSVLKYFTKLCYLTVHINSTFLNDLLDNDAFFAF 669
Query: 578 TKTL------LKSSNHSSLPW--CLNLCSEYTKNLKAEDIGTMIDIGISSLPIANCLPNS 629
+ + + + ++ W +C E + ++ N +
Sbjct: 670 IRNIDTIIPFIDDAKTAAFIWKQITAICVEMSLDMDQMSASLFSTAMNFIRKKNNTSISG 729
Query: 630 IEILLNCF-----NVAQQIESPIVLHNES-----VTIGNH---NIPFSLLVASFY---QD 673
+EI+LNC NV + +P V +ES + + N +P LV FY D
Sbjct: 730 LEIILNCLHFTLRNVNDDV-APTVGSSESHSVFLIKVNNDAAIELPIDQLVDLFYALNDD 788
Query: 674 NGRFDKYITKYTKLCSLPVGGKICSEVLKQERFIGRIHELFGTFKTSLIIQIDLLKFLKV 733
+ K I+ +TK+CSLP + ++ F +I F T+ SL+IQIDLLKF+K+
Sbjct: 789 DVNLSKLISIFTKICSLPGFENLTINIIFHPNFYEKIVSFFDTYFNSLLIQIDLLKFIKL 848
Query: 734 LV-------------------IQTNEQGKSSYFNK---LETLAKFLSSNWKNTQTFTPIK 771
+ + N + K++ F L + +FL++NW N K
Sbjct: 849 IFSKSLLKLYDYTGQPDPIKQTEPNRRNKATVFKLRAILVQITEFLNNNWNNGCP----K 904
Query: 772 QGHQKVGADSVLIHQLCQDIQNL 794
+ +VG DSVLI QLC+DI++L
Sbjct: 905 RNSNQVGGDSVLICQLCEDIRSL 927
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 227 bits (579), Expect = 5e-59
Identities = 123/258 (47%), Positives = 169/258 (64%), Gaps = 5/258 (1%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHMLEIDLLK 60
++I + L +G+GA+G VYR + + A+K+++ +S+L+ +EIDLLK
Sbjct: 2 HNIQASSITLGDCLGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLK 61
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKH-GPLLEDDTVNYVTQTLYGLQY 119
NL H NIV+YRG Q L IILEYC GSLR I K+ G + E+ Y Q L GL Y
Sbjct: 62 NLDHPNIVKYRGSYQTNDSLCIILEYCENGSLRSICKNFGKIPENLVALYTFQVLQGLLY 121
Query: 120 LHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA-MTYAGSPNWMAPEVMTGQGA 178
LH QGVIHRDIK AN+L T++G +KLADFGV+T+IN + + GSP WMAPEV+ GA
Sbjct: 122 LHNQGVIHRDIKGANILTTKDGTIKLADFGVATKINALEDHSVVGSPYWMAPEVIELVGA 181
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP-PLTLSAECKDFLSRCFQ 237
+T SDIWS+G TV+ELL GNPP+++L SA + +V +E+ P P +S+ K FL +CFQ
Sbjct: 182 TTASDIWSVGCTVIELLDGNPPYYDLDPTSALFRMVKDEHPPLPSNISSAAKSFLMQCFQ 241
Query: 238 KNMFKRATAQELLAHIWL 255
K+ R ++LL H W+
Sbjct: 242 KDPNLRIKTRKLLKHPWV 259
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 222 bits (566), Expect = 2e-57
Identities = 123/260 (47%), Positives = 167/260 (63%), Gaps = 9/260 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHMLEIDLLKNLRHQNI 67
Y L IG+GAYG VY+ + AIKQ+ E+ + +LN M EIDLLKNL H+NI
Sbjct: 20 YMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIVQEDLNTIMQEIDLLKNLNHKNI 79
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILK---HGPLLEDDTVNYVTQTLYGLQYLHEQG 124
V+Y G + L+IILEY GSL +I+K GP E Y+ Q L GL YLHEQG
Sbjct: 80 VKYLGSSKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQVLEGLVYLHEQG 139
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM---TYAGSPNWMAPEVMTGQGASTV 181
VIHRDIK AN+L T+EG+VKLADFGV+T++N + + G+P WMAPEV+ G
Sbjct: 140 VIHRDIKGANILTTKEGLVKLADFGVATKLNEADVNTHSVVGTPYWMAPEVIEMSGVCAA 199
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP-PLTLSAECKDFLSRCFQKNM 240
SDIWS+G TV+ELLT PP+++L A + IV ++ P P +LS + DFL +CF+K+
Sbjct: 200 SDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDDNPPIPDSLSPDITDFLRQCFKKDS 259
Query: 241 FKRATAQELLAHIWLKKIQK 260
+R A+ LL+H W++ ++
Sbjct: 260 RQRPDAKTLLSHPWIRNSRR 279
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 221 bits (563), Expect = 3e-57
Identities = 123/260 (47%), Positives = 165/260 (63%), Gaps = 9/260 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHMLEIDLLKNLRHQNI 67
Y L IG+GAYG VY + AIKQ+ E+ + +LN M EIDLLKNL H+NI
Sbjct: 20 YMLGDEIGKGAYGRVYIGLDLENGDFVAIKQVSLENIGQEDLNTIMQEIDLLKNLNHKNI 79
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILK---HGPLLEDDTVNYVTQTLYGLQYLHEQG 124
V+Y G ++ L+IILEY GSL +I+K GP E Y+ Q L GL YLHEQG
Sbjct: 80 VKYLGSLKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVTVYIAQVLEGLVYLHEQG 139
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINRM---AMTYAGSPNWMAPEVMTGQGASTV 181
VIHRDIK AN+L T+EG+VKLADFGV+T++N + G+P WMAPEV+ G
Sbjct: 140 VIHRDIKGANILTTKEGLVKLADFGVATKLNEADFNTHSVVGTPYWMAPEVIELSGVCAA 199
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP-PLTLSAECKDFLSRCFQKNM 240
SDIWS+G T++ELLT PP+++L A Y IV ++ P P +LS + DFL CF+K+
Sbjct: 200 SDIWSVGCTIIELLTCVPPYYDLQPMPALYRIVQDDTPPIPDSLSPDITDFLRLCFKKDS 259
Query: 241 FKRATAQELLAHIWLKKIQK 260
+R A+ LL+H W++ ++
Sbjct: 260 RQRPDAKTLLSHPWIRNSRR 279
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 182 bits (462), Expect = 2e-45
Identities = 109/275 (39%), Positives = 159/275 (57%), Gaps = 17/275 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQI----EFEDESELNEHMLEID----LLKNLRHQ 65
Q+IGRGA+G VY + + + A+KQ+ F + + H+ E++ LLKNL H
Sbjct: 73 QLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHP 132
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV Y G +++ L I+LE+ GS+ +L K GP E Y Q L GL+YLH
Sbjct: 133 NIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHNHA 192
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA-MTYA----GSPNWMAPEVMTGQGAS 179
++HRDIK AN+L+ +G +KLADFG S ++ +A MT A G+P WMAPEV+ G S
Sbjct: 193 IMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHS 252
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNE-SACYAIVNEEYIPPL--TLSAECKDFLSRCF 236
+DIWS+G TV+E++TG P+ E +A + I + PP+ TLS++ KDFL +C
Sbjct: 253 FSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKCL 312
Query: 237 QKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYI 271
Q+ R TA ELL H ++ K + +L +
Sbjct: 313 QEVPNLRPTASELLKHPFVMGKHKESASTDLGSVL 347
>At3g15220 [T] KOG0201 Serine/threonine protein kinase
Length = 690
Score = 180 bits (456), Expect = 9e-45
Identities = 111/276 (40%), Positives = 166/276 (59%), Gaps = 16/276 (5%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIVEYRG 72
++IGRG++G VY+A + NK AIK I+ E+ E E+ + EI +L R I EY G
Sbjct: 19 ELIGRGSFGDVYKAFDKDLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYG 78
Query: 73 FIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTL-YGLQYLHEQGVIHRDIK 131
+L+II+EY A GS+ D+L+ L++ ++ +T+ L + ++YLH +G IHRDIK
Sbjct: 79 SYLHQTKLWIIMEYMAGGSVADLLQSNNPLDETSIACITRDLLHAVEYLHNEGKIHRDIK 138
Query: 132 AANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVM-TGQGASTVSDIWSL 187
AAN+LL+E G VK+ADFGVS ++ R T+ G+P WMAPEV+ +G + +DIWSL
Sbjct: 139 AANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSL 198
Query: 188 GATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLT---LSAECKDFLSRCFQKNMFKRA 244
G TV+E+ G PP +L + I E PP S + K+F+S C +K +R
Sbjct: 199 GITVIEMAKGEPPLADLHPMRVLFIIPRE--TPPQLDEHFSRQVKEFVSLCLKKAPAERP 256
Query: 245 TAQELLAHIWLKKIQK-PKSKINLAEYIEKDGKWDV 279
+A+EL+ H ++K +K PK L E I + K+ V
Sbjct: 257 SAKELIKHRFIKNARKSPK----LLERIRERPKYQV 288
>At1g53165 [T] KOG0201 Serine/threonine protein kinase
Length = 1007
Score = 178 bits (452), Expect = 3e-44
Identities = 115/298 (38%), Positives = 173/298 (57%), Gaps = 18/298 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIVEYRG 72
++IGRG++G VY+A NK AIK I+ E+ E E+ + EI +L R I EY G
Sbjct: 346 ELIGRGSFGDVYKAFDTELNKDVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYG 405
Query: 73 FIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTL-YGLQYLHEQGVIHRDIK 131
+L+II+EY A GS+ D+L+ G L++ ++ +T+ L + ++YLH +G IHRDIK
Sbjct: 406 SYLHQTKLWIIMEYMAGGSVADLLQPGNPLDEISIACITRDLLHAVEYLHAEGKIHRDIK 465
Query: 132 AANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVM-TGQGASTVSDIWSL 187
AAN+LL+E G VK+ADFGVS ++ R T+ G+P WMAPEV+ +G + +DIWSL
Sbjct: 466 AANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSL 525
Query: 188 GATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLT---LSAECKDFLSRCFQKNMFKRA 244
G T++E+ G PP +L + I E PP S K+F+S C +K +R
Sbjct: 526 GITMIEMAKGEPPLADLHPMRVLFIIPRES--PPQLDEHFSRPLKEFVSFCLKKAPAERP 583
Query: 245 TAQELLAHIWLKKIQK-PKSKINLAEYIEKDGKWDV--DFVLDSNTDMTPSPTKSPIQ 299
A+ELL H ++K +K PK L E I + K+ V D + +N P+ + ++
Sbjct: 584 NAKELLKHRFIKNARKSPK----LLERIRERPKYQVKEDEEIPTNGPKAPAESSGTVR 637
>At5g66850 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 177 bits (448), Expect = 7e-44
Identities = 105/270 (38%), Positives = 149/270 (54%), Gaps = 17/270 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIE-FEDESELNEHML----EIDLLKNLRHQNIV 68
++IGRG +G VY A T CA+K++E F D+ + E + EI LL NL+H NIV
Sbjct: 9 KLIGRGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQLEQEIKLLSNLQHPNIV 68
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKH--GPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
+Y G +I LEY GS+ ++ G + E N+ L GL YLH + +
Sbjct: 69 QYFGSETVEDRFFIYLEYVHPGSINKYIRDHCGTMTESVVRNFTRHILSGLAYLHNKKTV 128
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRIN--RMAMTYAGSPNWMAPEVM--------TGQ 176
HRDIK ANLL+ G+VKLADFG++ + R ++ GSP WMAPEV+ +
Sbjct: 129 HRDIKGANLLVDASGVVKLADFGMAKHLTGQRADLSLKGSPYWMAPEVLMQAVMQKDSNP 188
Query: 177 GASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCF 236
+ DIWSLG T++E+ TG PP+ +A + ++ + P ++S E KDFL CF
Sbjct: 189 DLAFAVDIWSLGCTIIEMFTGKPPWSEFEGAAAMFKVMRDSPPIPESMSPEGKDFLRLCF 248
Query: 237 QKNMFKRATAQELLAHIWLKKIQKPKSKIN 266
Q+N +R TA LL H +LK +P S N
Sbjct: 249 QRNPAERPTASMLLEHRFLKNSLQPTSPSN 278
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 176 bits (445), Expect = 2e-43
Identities = 104/288 (36%), Positives = 164/288 (56%), Gaps = 14/288 (4%)
Query: 1 MDNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE-DESELNEHMLEIDLL 59
M+N+ A Y +++GRG+YG VYR + T + AIK + + DE E+++ E+ +L
Sbjct: 1 MENNTASSPYTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVL 60
Query: 60 KNLRH---QNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYG 116
L+ +NI++Y G L+II++YC GS+R +++ GP+ E + +TL
Sbjct: 61 SELKQSDVENIIKYHGSYLVGTNLWIIMDYCHGGSVRTLMEAGPISEPCISLILRETLQA 120
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVM 173
L+++H G+IHRDIKAAN+L++ G VKL DFGV+ +N R +T+ G+P WMAPEV+
Sbjct: 121 LKFIHHAGIIHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVI 180
Query: 174 -TGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL---TLSAECK 229
GQ + ++DIWSLG T E+ TG+PP A Y I + PP SA K
Sbjct: 181 RDGQEYNVMADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHT--APPRLNGNFSALLK 238
Query: 230 DFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKW 277
+F++ C Q +R + ELL ++K+ + S L +++ W
Sbjct: 239 EFIASCLQDVPQRRLDSSELLKSKFIKQYSR-MSISELTNVVKRYDTW 285
>Hs15011880 [T] KOG0201 Serine/threonine protein kinase
Length = 416
Score = 174 bits (440), Expect = 6e-43
Identities = 112/312 (35%), Positives = 168/312 (52%), Gaps = 17/312 (5%)
Query: 1 MDNSIA--HGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEID 57
M N+IA + + IG+G++G V++ + T + AIK I+ E+ E E+ + EI
Sbjct: 13 MQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEIT 72
Query: 58 LLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGL 117
+L + +Y G K +L+II+EY GS D+L+ GP E + + L GL
Sbjct: 73 VLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGL 132
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVS-----TRINRMAMTYAGSPNWMAPEV 172
YLH + IHRDIKAAN+LL+E+G VKLADFGV+ T+I R T+ G+P WMAPEV
Sbjct: 133 DYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKR--NTFVGTPFWMAPEV 190
Query: 173 MTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL---SAECK 229
+ + +DIWSLG T +EL G PP ++ + I PP + + K
Sbjct: 191 IQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNN--PPTLVGDFTKSFK 248
Query: 230 DFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDM 289
+F+ C K+ R TA+ELL H ++ K K S L E I++ +W + D +D
Sbjct: 249 EFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTS--YLTELIDRFKRWKAEGHSDDESDS 306
Query: 290 TPSPTKSPIQED 301
S ++S +E+
Sbjct: 307 EGSDSESTSREN 318
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 173 bits (438), Expect = 1e-42
Identities = 103/270 (38%), Positives = 154/270 (56%), Gaps = 11/270 (4%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEF---EDESELNEHML--EIDLLKNLRHQNIV 68
+++G G++G VY + + CA+K++ + +S + L EI +L LRHQNIV
Sbjct: 404 RLLGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLRHQNIV 463
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIH 127
+Y G +LYI LEY + GS+ +L+ +G E+ NY Q L GL YLH + +H
Sbjct: 464 QYYGSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIRNYTQQILSGLAYLHAKNTVH 523
Query: 128 RDIKAANLLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVM-TGQGASTVSDI 184
RDIK AN+L+ G VK+ADFG++ I + +++ GSP WMAPEV+ G++ DI
Sbjct: 524 RDIKGANILVDPHGRVKVADFGMAKHITAQSGPLSFKGSPYWMAPEVIKNSNGSNLAVDI 583
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKNMFK 242
WSLG TV+E+ T PP+ A + I N + +P P LS E KDF+ +C Q+N
Sbjct: 584 WSLGCTVLEMATTKPPWSQYEGVPAMFKIGNSKELPDIPDHLSEEGKDFVRKCLQRNPAN 643
Query: 243 RATAQELLAHIWLKKIQKPKSKINLAEYIE 272
R TA +LL H +++ + + I E E
Sbjct: 644 RPTAAQLLDHAFVRNVMPMERPIVSGEPAE 673
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 172 bits (437), Expect = 1e-42
Identities = 99/258 (38%), Positives = 147/258 (56%), Gaps = 17/258 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQI--------EFEDESELNEHMLEIDLLKNLRHQ 65
Q+IGRGA+G VY + + + A+KQ+ + + ++ + E E+ LLKNL H
Sbjct: 72 QLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHP 131
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV Y G +++ L I+LE+ GS+ +L K G E Y Q L GL+YLH
Sbjct: 132 NIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEYLHNHA 191
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINRM-----AMTYAGSPNWMAPEVMTGQGAS 179
++HRDIK AN+L+ +G +KLADFG S ++ + A + G+P WMAPEV+ G S
Sbjct: 192 IMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTGHS 251
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNE-SACYAIVNEEYIPPL--TLSAECKDFLSRCF 236
+DIWS+G TV+E++TG P+ E +A + I + PP+ +S++ DFL +C
Sbjct: 252 FSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPDNISSDANDFLLKCL 311
Query: 237 QKNMFKRATAQELLAHIW 254
Q+ R TA ELL W
Sbjct: 312 QQEPNLRPTASELLKVKW 329
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 172 bits (435), Expect = 2e-42
Identities = 103/256 (40%), Positives = 153/256 (59%), Gaps = 11/256 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG V++A+ + + + AIKQ+ E S+L E + EI +++ +V+Y G
Sbjct: 33 LGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIMQQCDSPYVVKYYGSYF 90
Query: 76 KAHELYIILEYCARGSLRDI--LKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K +L+I++EYC GS+ DI L++ L+ED+ + TL GL+YLH IHRDIKA
Sbjct: 91 KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAG 150
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL EG KLADFGV+ ++ + MA T G+P WMAPEV+ G + V+DIWSLG T
Sbjct: 151 NILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGIT 210
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ ++ A + I + P S + DF+ +C KN +RATA
Sbjct: 211 SIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT 270
Query: 248 ELLAHIWLKKIQKPKS 263
+LL H ++K KP S
Sbjct: 271 QLLQHPFIKN-AKPVS 285
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 172 bits (435), Expect = 2e-42
Identities = 103/256 (40%), Positives = 153/256 (59%), Gaps = 11/256 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG V++A+ + + + AIKQ+ E S+L E + EI +++ +V+Y G
Sbjct: 33 LGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIMQQCDSPYVVKYYGSYF 90
Query: 76 KAHELYIILEYCARGSLRDI--LKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K +L+I++EYC GS+ DI L++ L+ED+ + TL GL+YLH IHRDIKA
Sbjct: 91 KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAG 150
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL EG KLADFGV+ ++ + MA T G+P WMAPEV+ G + V+DIWSLG T
Sbjct: 151 NILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGIT 210
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ ++ A + I + P S + DF+ +C KN +RATA
Sbjct: 211 SIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATAT 270
Query: 248 ELLAHIWLKKIQKPKS 263
+LL H ++K KP S
Sbjct: 271 QLLQHPFIKN-AKPVS 285
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 171 bits (434), Expect = 3e-42
Identities = 102/266 (38%), Positives = 152/266 (56%), Gaps = 18/266 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQI--------EFEDESELNEHMLEIDLLKNLRHQ 65
++IG GA+G VY + + + AIKQ+ + + + + E E+ LLKNL H
Sbjct: 72 ELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHP 131
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV Y G ++++ L I++E+ GS+ +L K G E + Y Q L GL+YLH G
Sbjct: 132 NIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNG 191
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINRM-----AMTYAGSPNWMAPEVMTGQGAS 179
++HRDIK AN+L+ +G ++LADFG S ++ + A + G+P WMAPEV+ G S
Sbjct: 192 IMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGHS 251
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNE-SACYAIVNEEYIPPL--TLSAECKDFLSRCF 236
+DIWS+G TV+E+ TG PP+ + +A I + PP+ LS E KDFL +C
Sbjct: 252 FSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFLMKCL 311
Query: 237 QKNMFKRATAQELLAHIWLK-KIQKP 261
K R +A ELL H ++ K Q+P
Sbjct: 312 HKEPSLRLSATELLQHPFVTGKRQEP 337
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 171 bits (432), Expect = 5e-42
Identities = 102/262 (38%), Positives = 150/262 (56%), Gaps = 17/262 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES-----ELNEHMLEIDLLKNLRH 64
+ L +++G+GA+G VY T + A+KQ++F+ +S E+N EI LLKN H
Sbjct: 355 WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNFLH 414
Query: 65 QNIVEYRGFIQKAHE--LYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLH 121
+ IV+Y G ++ E L I +EY GS++D LK +G L E+ T Y Q L G+ YLH
Sbjct: 415 ERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQILEGVHYLH 474
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM------TYAGSPNWMAPEVMTG 175
++HRDIK AN+L G VKL DFG S R+ + + + G+P WM+PEV++G
Sbjct: 475 SNMILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG 534
Query: 176 QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLS 233
QG +DIWS+ TVVE+LT PP+ +A + I + P P +S +DFL
Sbjct: 535 QGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLK 594
Query: 234 RCFQKNMFKRATAQELLAHIWL 255
R F + R +A ELL H+++
Sbjct: 595 RIFVEAKL-RPSADELLRHMFV 615
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 171 bits (432), Expect = 5e-42
Identities = 102/255 (40%), Positives = 148/255 (58%), Gaps = 17/255 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES-----ELNEHMLEIDLLKNLRHQNIV 68
+++G+GA+G VY T + A KQ++F+ +S E++ EI LLKNL+H+ IV
Sbjct: 366 KLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIV 425
Query: 69 EYRGFIQKAHE--LYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
+Y G ++ E L I +EY GS++D LK +G L E T Y Q L G+ YLH +
Sbjct: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMI 485
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM------TYAGSPNWMAPEVMTGQGAS 179
+HRDIK AN+L G VKL DFG S R+ + M + G+P WM+PEV++G+G
Sbjct: 486 VHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYG 545
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQ 237
+D+WSLG TVVE+LT PP+ +A + I + P P +S +DFL R F
Sbjct: 546 RKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIFV 605
Query: 238 KNMFKRATAQELLAH 252
+ +R +A+ELL H
Sbjct: 606 EAR-QRPSAEELLTH 619
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 170 bits (431), Expect = 7e-42
Identities = 100/249 (40%), Positives = 149/249 (59%), Gaps = 10/249 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG VY+A+ + T + AIKQ+ E S+L E + EI +++ ++V+Y G
Sbjct: 36 LGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIMQQCDSPHVVKYYGSYF 93
Query: 76 KAHELYIILEYCARGSLRDI--LKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K +L+I++EYC GS+ DI L++ L ED+ + TL GL+YLH IHRDIKA
Sbjct: 94 KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAG 153
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL EG KLADFGV+ ++ + MA T G+P WMAPEV+ G + V+DIWSLG T
Sbjct: 154 NILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGIT 213
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ ++ A + I + P S DF+ +C K+ +RATA
Sbjct: 214 AIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATAT 273
Query: 248 ELLAHIWLK 256
+LL H +++
Sbjct: 274 QLLQHPFVR 282
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 170 bits (431), Expect = 7e-42
Identities = 103/249 (41%), Positives = 147/249 (58%), Gaps = 10/249 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG VY+AV + ++ AIK + E S+L+E + EI +++ +V Y G
Sbjct: 48 LGEGSYGSVYKAVHKESSSIVAIKLVPVE--SDLHEIIKEISIMQQCDSPYVVRYYGSYF 105
Query: 76 KAHELYIILEYCARGSLRDI--LKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K ++L+I +EYC GS+ DI L+ L ED+ ++ TL GL YLH + IHRDIKAA
Sbjct: 106 KQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAA 165
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL EG KLADFGV+ ++ + MA T G+P WMAPEV+ G V+DIWSLG T
Sbjct: 166 NILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGIT 225
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ + A + I + + P S E DF+S+C K RATA
Sbjct: 226 ALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATAT 285
Query: 248 ELLAHIWLK 256
ELL H +++
Sbjct: 286 ELLEHEFIR 294
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 170 bits (430), Expect = 9e-42
Identities = 99/266 (37%), Positives = 146/266 (54%), Gaps = 11/266 (4%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNLR 63
T+ + +G G +G VY K CAIK+++ + + ++ L EI+LL L
Sbjct: 213 TWKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINLLNQLC 272
Query: 64 HQNIVEYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHE 122
H NIV+Y G L + LEY + GS+ +LK +G E NY Q L GL YLH
Sbjct: 273 HPNIVQYYGSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLAYLHG 332
Query: 123 QGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVMTGQ-GAS 179
+ +HRDIK AN+L+ G +KLADFG++ + + +++ GSP WMAPEV+ Q G +
Sbjct: 333 RNTVHRDIKGANILVDPNGEIKLADFGMAKHVTAFSTMLSFKGSPYWMAPEVVMSQNGYT 392
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQ 237
DIWSLG T++E+ T PP+ +A + I N + P P LS + K+F+ C Q
Sbjct: 393 HAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKIGNSKDTPEIPDHLSNDAKNFIRLCLQ 452
Query: 238 KNMFKRATAQELLAHIWLKKIQKPKS 263
+N R TA +LL H +L+ + S
Sbjct: 453 RNPTVRPTASQLLEHPFLRNTTRVAS 478
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 169 bits (429), Expect = 1e-41
Identities = 105/284 (36%), Positives = 162/284 (56%), Gaps = 21/284 (7%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML--------EIDLLKNLRHQ 65
++IG+G++G VY + T + A+KQ+E S NE +L E+ LK+L H
Sbjct: 1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHL 1238
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVT-QTLYGLQYLHEQG 124
NIV+Y GF K + + LEY A GS+ +++ ++ + ++T Q L GL YLH +G
Sbjct: 1239 NIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKG 1298
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTR----INRMAMTYAGSPNWMAPEVM-TGQGAS 179
++HRD+KA NLLL ++GI K++DFG+S + + MT G+ WMAPE++ T QG S
Sbjct: 1299 ILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYS 1358
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL------TLSAECKDFLS 233
DIWSLG V+E+ G P+ NL +A + I + PP+ +S ++FL
Sbjct: 1359 AKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLD 1418
Query: 234 RCFQKNMFKRATAQELLAHIWLKKIQKPKSK-INLAEYIEKDGK 276
CF+ N KR TA ELL+H + + + K LA++I+ + K
Sbjct: 1419 ACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKSNDK 1462
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 169 bits (429), Expect = 1e-41
Identities = 104/273 (38%), Positives = 152/273 (55%), Gaps = 13/273 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIVEYRGFI 74
IG+G++G V++ + T K AIK I+ E+ E E+ + EI +L + +Y G
Sbjct: 42 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 101
Query: 75 QKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAAN 134
K +L+II+EY GS D+L+ GPL E + + L GL YLH + IHRDIKAAN
Sbjct: 102 LKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAAN 161
Query: 135 LLLTEEGIVKLADFGVS-----TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGA 189
+LL+E G VKLADFGV+ T+I R T+ G+P WMAPEV+ + +DIWSLG
Sbjct: 162 VLLSEHGEVKLADFGVAGQLTDTQIKR--NTFVGTPFWMAPEVIKQSAYDSKADIWSLGI 219
Query: 190 TVVELLTGNPPFHNLVNESACYAIVNEEYIPPL--TLSAECKDFLSRCFQKNMFKRATAQ 247
T +EL G PP H+ ++ ++ + P L S K+F+ C K R TA+
Sbjct: 220 TAIELARGEPP-HSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAK 278
Query: 248 ELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVD 280
ELL H ++ ++ K L E I++ +W +
Sbjct: 279 ELLKHKFI--LRNAKKTSYLTELIDRYKRWKAE 309
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 169 bits (427), Expect = 2e-41
Identities = 109/272 (40%), Positives = 150/272 (55%), Gaps = 17/272 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIVEYRGFI 74
IG+G++G VY+ + T + AIK I+ E+ E E+ + EI +L I Y G
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 85
Query: 75 QKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAAN 134
K+ +L+II+EY GS D+LK GPL E + + L GL YLH + IHRDIKAAN
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAAN 145
Query: 135 LLLTEEGIVKLADFGVS-----TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGA 189
+LL+E+G VKLADFGV+ T+I R T+ G+P WMAPEV+ +DIWSLG
Sbjct: 146 VLLSEQGDVKLADFGVAGQLTDTQIKR--NTFVGTPFWMAPEVIKQSAYDFKADIWSLGI 203
Query: 190 TVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL----SAECKDFLSRCFQKNMFKRAT 245
T +EL G PP +L + I P TL S K+F+ C K+ R T
Sbjct: 204 TAIELAKGEPPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPT 260
Query: 246 AQELLAHIWLKKIQKPKSKINLAEYIEKDGKW 277
A+ELL H ++ + K S L E I++ +W
Sbjct: 261 AKELLKHKFITRYTKKTS--FLTELIDRYKRW 290
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 169 bits (427), Expect = 2e-41
Identities = 109/272 (40%), Positives = 150/272 (55%), Gaps = 17/272 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIVEYRGFI 74
IG+G++G VY+ + T + AIK I+ E+ E E+ + EI +L I Y G
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 85
Query: 75 QKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAAN 134
K+ +L+II+EY GS D+LK GPL E + + L GL YLH + IHRDIKAAN
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAAN 145
Query: 135 LLLTEEGIVKLADFGVS-----TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGA 189
+LL+E+G VKLADFGV+ T+I R T+ G+P WMAPEV+ +DIWSLG
Sbjct: 146 VLLSEQGDVKLADFGVAGQLTDTQIKR--NTFVGTPFWMAPEVIKQSAYDFKADIWSLGI 203
Query: 190 TVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL----SAECKDFLSRCFQKNMFKRAT 245
T +EL G PP +L + I P TL S K+F+ C K+ R T
Sbjct: 204 TAIELAKGEPPNSDLHPMRVLFLIPKNS---PPTLEGQHSKPFKEFVEACLNKDPRFRPT 260
Query: 246 AQELLAHIWLKKIQKPKSKINLAEYIEKDGKW 277
A+ELL H ++ + K S L E I++ +W
Sbjct: 261 AKELLKHKFITRYTKKTS--FLTELIDRYKRW 290
>7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 1218
Score = 169 bits (427), Expect = 2e-41
Identities = 103/256 (40%), Positives = 144/256 (56%), Gaps = 14/256 (5%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y L Q IG G YG VY+A + +N+ AIK I+ E ++ EI ++++ RH NI+
Sbjct: 26 YELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHPNIIA 85
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
Y G + +L+I +E+C GSL+DI + GPL E +TL GL+YLH G +HR
Sbjct: 86 YYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHR 145
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQ---GASTVS 182
DIK AN+LLTE G VKLADFGVS +I ++ G+P WMAPEV + G + +
Sbjct: 146 DIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLC 205
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECK------DFLSRCF 236
DIW+ G T +EL PP +L A + + + PP TL+ + K +F+
Sbjct: 206 DIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPP-TLNNKDKWSPTFHNFIKTAL 264
Query: 237 QKNMFKRATAQELLAH 252
KN KR TA+ LL H
Sbjct: 265 TKNPKKRPTAERLLQH 280
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 167 bits (424), Expect = 4e-41
Identities = 110/304 (36%), Positives = 166/304 (54%), Gaps = 21/304 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES-ELNEHMLEIDLLKNLRH-QNIVEYR 71
+VIGRG +GVVY+ T + AIK + + +S E+ + EI L +L+ NI Y
Sbjct: 27 EVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYY 86
Query: 72 GFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIK 131
G K L+II+E+CA GSLR +L+ G + E + + L L+ +H+ VIHRDIK
Sbjct: 87 GSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIK 146
Query: 132 AANLLLTEEGIVKLADFGVSTRINRMAM---TYAGSPNWMAPEV-MTGQGASTVSDIWSL 187
AAN+L+T EG VKL DFGV+ ++N+ ++ T AG+P WMAPEV M G T DIWSL
Sbjct: 147 AANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSL 206
Query: 188 GATVVELLTGNPPFHNLVNESACYAIVNEEYIPP----LTLSAECKDFLSRCFQKNMFKR 243
G T E+ TGNPP+ ++ A I+ + PP + S K+F++ C ++ +R
Sbjct: 207 GITTYEIATGNPPYCDVEALRAMQLIIKSK--PPRLEDRSYSTSLKEFIALCLDEDPKER 264
Query: 244 ATAQELLAHIWLKKIQKPKSKINLAEYIEK--------DGKWDVDFVLDSNTDMTPSPTK 295
+A +LL +++ + + I L E I + K+ ++ + N PS
Sbjct: 265 LSADDLLKSKFIRAHKATPTSI-LKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEAP 323
Query: 296 SPIQ 299
P Q
Sbjct: 324 KPSQ 327
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 167 bits (424), Expect = 4e-41
Identities = 95/256 (37%), Positives = 140/256 (54%), Gaps = 17/256 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLLKNLRHQNIVEYRGF 73
IG G YG VY + T + A+K+I F+ D + E E+ + + ++H N+V Y G
Sbjct: 1299 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1358
Query: 74 IQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGLQYLHEQGVIHRDIKA 132
E+YI +EYC G+L ++ + G L++ + Y Q + LHE G++HRDIK
Sbjct: 1359 ELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVIRLYSKQITIAINVLHEHGIVHRDIKG 1416
Query: 133 ANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPN-------WMAPEVMT---GQGASTVS 182
AN+ LT G++KL DFG S ++ A T G N +MAPEV+T G+G +
Sbjct: 1417 ANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA 1476
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL--TLSAECKDFLSRCFQKNM 240
DIWSLG V+E++TG P+H + V + PP+ LS E KDFLS C + +
Sbjct: 1477 DIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDP 1536
Query: 241 FKRATAQELLAHIWLK 256
R TA +LL H ++K
Sbjct: 1537 KMRWTASQLLDHSFVK 1552
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 167 bits (424), Expect = 4e-41
Identities = 95/256 (37%), Positives = 140/256 (54%), Gaps = 17/256 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLLKNLRHQNIVEYRGF 73
IG G YG VY + T + A+K+I F+ D + E E+ + + ++H N+V Y G
Sbjct: 1348 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1407
Query: 74 IQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGLQYLHEQGVIHRDIKA 132
E+YI +EYC G+L ++ + G L++ + Y Q + LHE G++HRDIK
Sbjct: 1408 ELHREEMYIFMEYCDEGTLEEVSRLG--LQEHVIRLYSKQITIAINVLHEHGIVHRDIKG 1465
Query: 133 ANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPN-------WMAPEVMT---GQGASTVS 182
AN+ LT G++KL DFG S ++ A T G N +MAPEV+T G+G +
Sbjct: 1466 ANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAA 1525
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL--TLSAECKDFLSRCFQKNM 240
DIWSLG V+E++TG P+H + V + PP+ LS E KDFLS C + +
Sbjct: 1526 DIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDP 1585
Query: 241 FKRATAQELLAHIWLK 256
R TA +LL H ++K
Sbjct: 1586 KMRWTASQLLDHSFVK 1601
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 167 bits (424), Expect = 4e-41
Identities = 107/292 (36%), Positives = 156/292 (52%), Gaps = 17/292 (5%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
+ ++ IGRG++G VY+ + T + AIK I+ E E E+ + EI +L Q +
Sbjct: 32 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVT 91
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
+Y G K +L+II+EY GS D+ K G L E + + L GL+YLH + IHR
Sbjct: 92 KYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHR 151
Query: 129 DIKAANLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIW 185
DIKAAN+L++E G VK+ADFGV+ T + +T+ GSP WMAPE++ +DIW
Sbjct: 152 DIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIW 211
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL-----SAECKDFLSRCFQKNM 240
SLG T +EL G PP +L + I PP L S K+F+ C K+
Sbjct: 212 SLGITAIELANGEPPHSDLHPMRVLFLIPKN---PPPVLQGSQWSKPFKEFVEMCLNKDP 268
Query: 241 FKRATAQELLAHIWLKKIQKPKSKINL----AEYIEKDGKWDVDFVLDSNTD 288
R +A LL H ++K+ +K ++L AEY + G D LD ++D
Sbjct: 269 ENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYRLRTGV-SSDSDLDEDSD 319
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 167 bits (424), Expect = 4e-41
Identities = 107/292 (36%), Positives = 156/292 (52%), Gaps = 17/292 (5%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
+ ++ IGRG++G VY+ + T + AIK I+ E E E+ + EI +L Q +
Sbjct: 34 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVT 93
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
+Y G K +L+II+EY GS D+ K G L E + + L GL+YLH + IHR
Sbjct: 94 KYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLDESHIAVILREILKGLEYLHSERKIHR 153
Query: 129 DIKAANLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIW 185
DIKAAN+L++E G VK+ADFGV+ T + +T+ GSP WMAPE++ +DIW
Sbjct: 154 DIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIW 213
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL-----SAECKDFLSRCFQKNM 240
SLG T +EL G PP +L + I PP L S K+F+ C K+
Sbjct: 214 SLGITAIELANGEPPHSDLHPMRVLFLIPKN---PPPVLQGSQWSKPFKEFVEMCLNKDP 270
Query: 241 FKRATAQELLAHIWLKKIQKPKSKINL----AEYIEKDGKWDVDFVLDSNTD 288
R +A LL H ++K+ +K ++L AEY + G D LD ++D
Sbjct: 271 ENRPSASTLLKHQFIKRAKKNSILVDLIERAAEYRLRTGV-SSDSDLDEDSD 321
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 167 bits (423), Expect = 6e-41
Identities = 105/297 (35%), Positives = 164/297 (54%), Gaps = 10/297 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
+ ++ IG+G++G V++ + T + AIK I+ E+ E E+++ EI +L +
Sbjct: 13 FTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVT 72
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
+Y G K +L+II+EY GS D++K G E + + L GL YLH + +HR
Sbjct: 73 KYYGSFLKGTKLWIIMEYLGGGSALDLMKAGSFEEMHIGIILREVLKGLDYLHSERKLHR 132
Query: 129 DIKAANLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIW 185
DIKAAN+LL+E+G VKLADFGV+ T T+ G+P WMAPEV+ +DIW
Sbjct: 133 DIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIW 192
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLT--LSAECKDFLSRCFQKNMFKR 243
SLG T +EL G PP ++ ++ ++ + P LT + KDF+ C K+ R
Sbjct: 193 SLGITAIELAKGEPP-NSELHPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENR 251
Query: 244 ATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMTPSPTKSPIQE 300
TA+ELL + ++KK +K I+L I++ KW V +S T+ S + S ++
Sbjct: 252 PTAKELLKYPFIKKAKKNAYLIDL---IDRFKKWKVSKGDESETESENSDSDSDAKQ 305
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 167 bits (422), Expect = 8e-41
Identities = 96/249 (38%), Positives = 147/249 (58%), Gaps = 10/249 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG V++A+ R + AIK++ + ++L E + EI +++ + + +V+Y G
Sbjct: 69 LGEGSYGSVHKAIHRESGHVLAIKKVPVD--TDLQEIIKEISIMQQCKSKYVVKYYGSYF 126
Query: 76 KAHELYIILEYCARGSLRDILK--HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K +L+I++EYC GS+ DI++ PL E + + TL GLQYLH+ IHRDIKA
Sbjct: 127 KHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAG 186
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL +GI KLADFGV+ ++ + MA T G+P WMAPEV+ G T +DIWSLG T
Sbjct: 187 NILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGIT 246
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ ++ A + I + + P S+E DF+ C K +R TA
Sbjct: 247 AIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTAL 306
Query: 248 ELLAHIWLK 256
L H ++K
Sbjct: 307 RLCEHTFIK 315
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 167 bits (422), Expect = 8e-41
Identities = 96/249 (38%), Positives = 147/249 (58%), Gaps = 10/249 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG V++A+ R + AIK++ + ++L E + EI +++ + + +V+Y G
Sbjct: 41 LGEGSYGSVHKAIHRESGHVLAIKKVPVD--TDLQEIIKEISIMQQCKSKYVVKYYGSYF 98
Query: 76 KAHELYIILEYCARGSLRDILK--HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K +L+I++EYC GS+ DI++ PL E + + TL GLQYLH+ IHRDIKA
Sbjct: 99 KHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAG 158
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL +GI KLADFGV+ ++ + MA T G+P WMAPEV+ G T +DIWSLG T
Sbjct: 159 NILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGIT 218
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ ++ A + I + + P S+E DF+ C K +R TA
Sbjct: 219 AIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTAL 278
Query: 248 ELLAHIWLK 256
L H ++K
Sbjct: 279 RLCEHTFIK 287
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 167 bits (422), Expect = 8e-41
Identities = 96/249 (38%), Positives = 147/249 (58%), Gaps = 10/249 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG V++A+ R + AIK++ + ++L E + EI +++ + + +V+Y G
Sbjct: 41 LGEGSYGSVHKAIHRESGHVLAIKKVPVD--TDLQEIIKEISIMQQCKSKYVVKYYGSYF 98
Query: 76 KAHELYIILEYCARGSLRDILK--HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K +L+I++EYC GS+ DI++ PL E + + TL GLQYLH+ IHRDIKA
Sbjct: 99 KHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAG 158
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL +GI KLADFGV+ ++ + MA T G+P WMAPEV+ G T +DIWSLG T
Sbjct: 159 NILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGIT 218
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ ++ A + I + + P S+E DF+ C K +R TA
Sbjct: 219 AIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTAL 278
Query: 248 ELLAHIWLK 256
L H ++K
Sbjct: 279 RLCEHTFIK 287
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 167 bits (422), Expect = 8e-41
Identities = 96/249 (38%), Positives = 147/249 (58%), Gaps = 10/249 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+YG V++A+ R + AIK++ + ++L E + EI +++ + + +V+Y G
Sbjct: 69 LGEGSYGSVHKAIHRESGHVLAIKKVPVD--TDLQEIIKEISIMQQCKSKYVVKYYGSYF 126
Query: 76 KAHELYIILEYCARGSLRDILK--HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
K +L+I++EYC GS+ DI++ PL E + + TL GLQYLH+ IHRDIKA
Sbjct: 127 KHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAG 186
Query: 134 NLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+LL +GI KLADFGV+ ++ + MA T G+P WMAPEV+ G T +DIWSLG T
Sbjct: 187 NILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGIT 246
Query: 191 VVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQ 247
+E+ G PP+ ++ A + I + + P S+E DF+ C K +R TA
Sbjct: 247 AIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTAL 306
Query: 248 ELLAHIWLK 256
L H ++K
Sbjct: 307 RLCEHTFIK 315
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 166 bits (421), Expect = 1e-40
Identities = 101/262 (38%), Positives = 150/262 (56%), Gaps = 17/262 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES-----ELNEHMLEIDLLKNLRH 64
+ L +++G+GA+G VY T + A+KQ++F+ +S E+N EI LLKNL H
Sbjct: 357 WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLH 416
Query: 65 QNIVEYRGFIQKAHE--LYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLH 121
+ IV+Y G ++ E L I +EY GS++D LK +G L E+ T Y Q L G+ YLH
Sbjct: 417 ERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH 476
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM------TYAGSPNWMAPEVMTG 175
++ RDIK AN+L G VKL DFG S R+ + + + G+P WM+PEV++G
Sbjct: 477 SNMIVLRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG 536
Query: 176 QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLS 233
+G +DIWS+ TVVE+LT PP+ +A + I + P P +S +DFL
Sbjct: 537 EGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLK 596
Query: 234 RCFQKNMFKRATAQELLAHIWL 255
R F + R +A ELL H+++
Sbjct: 597 RIFVEAKL-RPSADELLRHMFV 617
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 165 bits (417), Expect = 3e-40
Identities = 116/333 (34%), Positives = 173/333 (51%), Gaps = 26/333 (7%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDE-SELNEHMLEIDLLKNLRHQNI 67
+Y L + +G G++GVV++A + + AIKQI+ E ++ + E+ +L N N+
Sbjct: 8 SYTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNSSNV 67
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIH 127
++Y G + L+I++E+ GS+ +LK G L E + + LYGL YLH Q IH
Sbjct: 68 IQYYGCFVDGYTLWILMEHMDGGSVSGLLKMGRLNEQVISIILREVLYGLNYLHGQNKIH 127
Query: 128 RDIKAANLLLTEE-GIVKLADFGVSTRINRMAM---TYAGSPNWMAPEVMTGQGASTVSD 183
RDIKAAN+LL+ G VKLADFGV+ +++ A T+ G+P WMAPEV+ +D
Sbjct: 128 RDIKAANILLSSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQQTSYGLAAD 187
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLT---LSAECKDFLSRCFQKNM 240
IWSLG T +E+ G PP + + I E PP S +DF+S C N
Sbjct: 188 IWSLGITAIEMANGIPPRATMHPMRVIFEIPQSE--PPKLDDHFSPTFRDFVSCCLDLNP 245
Query: 241 FKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVD---FVLDSNTDMTPSPTKSP 297
R +A+ELL H ++K K I L ++K+ K D VL+ + T P + P
Sbjct: 246 NMRWSAKELLQHPFIKSAGTVKDIIPL--LVQKENKLFDDSDQSVLEETINNTLKPFEEP 303
Query: 298 IQE---DLAPADFRTLSVDQLFIEHSTDSIVVG 327
I E D+ F T+ +DS V+G
Sbjct: 304 IAEGNADIEDWTFETVK--------KSDSTVLG 328
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 164 bits (416), Expect = 4e-40
Identities = 99/262 (37%), Positives = 144/262 (54%), Gaps = 6/262 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
YA IG+GA G VY A + GTN AIKQ+ E + + + EI ++K +H NIV
Sbjct: 620 YANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVN 679
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRD 129
+ +L++I+EY GSL D++ H L E +TL GL++LH +GV+HRD
Sbjct: 680 FIDSYVLKGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRD 739
Query: 130 IKAANLLLTEEGIVKLADFGVSTRINRMAM---TYAGSPNWMAPEVMTGQGASTVSDIWS 186
IK+ N+LL+ EG +KL DFG +IN + + T G+P WMAPEV++ + DIWS
Sbjct: 740 IKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWS 799
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKR 243
LG ++E++ G PP+ N A Y I + P LS+ K FL C R
Sbjct: 800 LGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDR 859
Query: 244 ATAQELLAHIWLKKIQKPKSKI 265
A+A ELL ++ +I + S +
Sbjct: 860 ASATELLHDEYITEIAEANSSL 881
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 164 bits (415), Expect = 5e-40
Identities = 108/323 (33%), Positives = 172/323 (52%), Gaps = 21/323 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G GA+G VY+A + T+ A K I+ + E EL ++M+EID+L + H NIV+
Sbjct: 40 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 99
Query: 76 KAHELYIILEYCARGSLRDIL--KHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
+ L+I++E+CA G++ ++ PL E QTL L YLH+ +IHRD+KA
Sbjct: 100 YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAG 159
Query: 134 NLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVMTGQGAST-----VSDIW 185
N+L T +G +KLADFGVS TR + ++ G+P WMAPEV+ + + +D+W
Sbjct: 160 NILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVW 219
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNEE---YIPPLTLSAECKDFLSRCFQKNMFK 242
SLG T++E+ PP H L I E P S+ KDFL +C +KN+
Sbjct: 220 SLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDA 279
Query: 243 RATAQELLAHIWL-----KKIQK--PKSKINLAEYIEKDGKWDVDFVLDSNTDMTPSPTK 295
R T +LL H ++ K I++ ++K + E +E DGK + + N+ P+ +
Sbjct: 280 RWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVE-DGKEEDEEEETENSLPIPASKR 338
Query: 296 SPIQEDLAPADFRTLSVDQLFIE 318
+ +A ++ LS + +E
Sbjct: 339 ASSDLSIASSEEDKLSQNACILE 361
>Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 545
Score = 161 bits (408), Expect = 3e-39
Identities = 99/262 (37%), Positives = 142/262 (53%), Gaps = 7/262 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y + IG+GA G VY A+ T + AIKQ+ + + + + EI +++ ++ NIV
Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 329
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRD 129
Y EL++++EY A GSL D++ + E + L L++LH VIHRD
Sbjct: 330 YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRD 389
Query: 130 IKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTVSDIWS 186
IK+ N+LL +G VKL DFG +I T G+P WMAPEV+T + DIWS
Sbjct: 390 IKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWS 449
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKR 243
LG +E++ G PP+ N A Y I E P LSA +DFL+RC ++ KR
Sbjct: 450 LGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEKR 509
Query: 244 ATAQELLAHIWLKKIQKPKSKI 265
+A+ELL H +L KI KP S +
Sbjct: 510 GSAKELLQHQFL-KIAKPLSSL 530
>Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 894
Score = 161 bits (408), Expect = 3e-39
Identities = 99/255 (38%), Positives = 138/255 (53%), Gaps = 12/255 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
+ L Q IG G YG VY+A T + AIK I+ E + EI ++K+ +H NIV
Sbjct: 16 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVA 75
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
Y G + +L+I +E+C GSL+DI GPL E +TL GL YLH +G +HR
Sbjct: 76 YFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHR 135
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQ---GASTVS 182
DIK AN+LLT+ G VKLADFGVS +I ++ G+P WMAPEV + G + +
Sbjct: 136 DIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLC 195
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPP-----LTLSAECKDFLSRCFQ 237
D+W++G T +EL PP +L A + + + PP + S F+
Sbjct: 196 DLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALT 255
Query: 238 KNMFKRATAQELLAH 252
KN KR TA++LL H
Sbjct: 256 KNPKKRPTAEKLLQH 270
>Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 846
Score = 161 bits (408), Expect = 3e-39
Identities = 108/295 (36%), Positives = 151/295 (50%), Gaps = 26/295 (8%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y L Q +G G YG VY+A T + A+K I+ E + + EI ++K +H NIV
Sbjct: 20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVA 79
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
Y G +L+I +EYC GSL+DI GPL E +TL GL YLH +G +HR
Sbjct: 80 YFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHR 139
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQ---GASTVS 182
DIK AN+LLT+ G VKLADFGV+ +I ++ G+P WMAPEV + G + +
Sbjct: 140 DIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLC 199
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPP-----LTLSAECKDFLSRCFQ 237
DIW++G T +EL PP +L A + + + PP S+ +F+
Sbjct: 200 DIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALT 259
Query: 238 KNMFKRATAQELLAHIWLKK-----------IQKPKSKINLAEYIEKDGKWDVDF 281
KN KR TA+ LL H ++ + + K + N A Y E D D DF
Sbjct: 260 KNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEAD---DDDF 311
>At4g08500 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 161 bits (407), Expect = 4e-39
Identities = 99/256 (38%), Positives = 147/256 (56%), Gaps = 15/256 (5%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNLRHQNIV 68
Q++GRG++G VY + G A+K++ D+ + + EI LL L+HQNIV
Sbjct: 337 QLLGRGSFGSVYEGIS-GDGDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQLQHQNIV 395
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
YRG + LYI LE +GSL + + L + Y Q L GL+YLH++G IHR
Sbjct: 396 RYRGTAKDGSNLYIFLELVTQGSLLKLYQRYQLRDSVVSLYTRQILDGLKYLHDKGFIHR 455
Query: 129 DIKAANLLLTEEGIVKLADFGVS--TRINRMAMTYAGSPNWMAPEVMT---GQGASTVSD 183
DIK AN+L+ G VKLADFG++ ++ N + + G+P WMAPEV+ G + +D
Sbjct: 456 DIKCANILVDANGAVKLADFGLAKVSKFNDI-KSCKGTPFWMAPEVINRKDSDGYGSPAD 514
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKNMF 241
IWSLG TV+E+ TG P+ +L A + I +P P TLS + + F+ +C + N
Sbjct: 515 IWSLGCTVLEMCTGQIPYSDLEPVQALFRI-GRGTLPEVPDTLSLDARLFILKCLKVNPE 573
Query: 242 KRATAQELLAHIWLKK 257
+R TA ELL H ++++
Sbjct: 574 ERPTAAELLNHPFVRR 589
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 160 bits (406), Expect = 5e-39
Identities = 117/332 (35%), Positives = 167/332 (50%), Gaps = 27/332 (8%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEF---EDESELNEHMLEIDLLKNLRHQNIVEYRG 72
IG G++G VY A TN+ AIK++ + + + + + E+ L+ L+H N +EY+G
Sbjct: 30 IGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKG 89
Query: 73 FIQKAHELYIILEYCARGSLRDILK--HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDI 130
K H ++++EYC GS D+L+ PL E + L+GL YLH +IHRDI
Sbjct: 90 CYLKEHTAWLVMEYCL-GSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDI 148
Query: 131 KAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVM----TGQGASTVSDIWS 186
KA N+LLTE G VKLADFG S + A ++ G+P WMAPEV+ GQ V DIWS
Sbjct: 149 KAGNILLTEPGQVKLADFG-SASMASPANSFVGTPYWMAPEVILAMDEGQYDGKV-DIWS 206
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKD----FLSRCFQKNMFK 242
LG T +EL PP N+ SA Y I + P S E D F+ C QK +
Sbjct: 207 LGITCIELAERKPPLFNMNAMSALYHIAQND--SPTLQSNEWTDSFRRFVDYCLQKIPQE 264
Query: 243 RATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVD--------FVLDSNTDMTPSPT 294
R T+ ELL H ++++ + + I+L + KD ++D +L T P
Sbjct: 265 RPTSAELLRHDFVRRDRPLRVLIDLIQR-TKDAVRELDNLQYRKMKKILFQETRNGPLNE 323
Query: 295 KSPIQEDLAPADFRTLSVDQLFIEHSTDSIVV 326
+ED +D L HS S+ V
Sbjct: 324 SQEDEEDSEHGTSLNREMDSLGSNHSIPSMSV 355
>SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 658
Score = 160 bits (405), Expect = 7e-39
Identities = 98/267 (36%), Positives = 146/267 (53%), Gaps = 6/267 (2%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
IG+GA G VY A + GTN AIK++ + + + EI ++K+ H+NIV +
Sbjct: 392 IGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFF 451
Query: 76 KAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANL 135
EL++++EY GSL +++ + L E +TL GLQ+LHE G++HRDIK+ N+
Sbjct: 452 YKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNI 511
Query: 136 LLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
LL+ +G +KL DFG +I+ T G+P WMAPEV+T + D+WSLG +
Sbjct: 512 LLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAI 571
Query: 193 ELLTGNPPFHNLVNESACYAIV---NEEYIPPLTLSAECKDFLSRCFQKNMFKRATAQEL 249
E++ G PP+ N A Y I + P LS+ DFLS+ N +R ++ EL
Sbjct: 572 EMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGEL 631
Query: 250 LAHIWLKKIQKPKSKINLAEYIEKDGK 276
L H +LK+ S I L + I GK
Sbjct: 632 LRHPFLKQAVPVSSLIPLIKSIHHSGK 658
>Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 544
Score = 159 bits (403), Expect = 1e-38
Identities = 97/262 (37%), Positives = 142/262 (54%), Gaps = 7/262 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y + IG+GA G VY A+ T + AIKQ+ + + + + EI +++ ++ NIV
Sbjct: 268 YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN 327
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRD 129
Y EL++++EY A GSL D++ + E + L L +LH VIHRD
Sbjct: 328 YLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRD 387
Query: 130 IKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTVSDIWS 186
IK+ N+LL +G VKL DFG +I T G+P WMAPEV+T + DIWS
Sbjct: 388 IKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWS 447
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKR 243
LG +E++ G PP+ N A Y I E P LSA +DFL+RC + ++ +R
Sbjct: 448 LGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRR 507
Query: 244 ATAQELLAHIWLKKIQKPKSKI 265
+A+ELL H +L K+ KP S +
Sbjct: 508 GSAKELLQHPFL-KLAKPLSSL 528
>SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1116
Score = 159 bits (401), Expect = 2e-38
Identities = 98/267 (36%), Positives = 148/267 (54%), Gaps = 24/267 (8%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-----ESELNEHML-----EIDLLKNLR 63
++IG G YG V+ A+ T + A+KQ+E +L + ++ EI ++ +L
Sbjct: 829 ELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLD 888
Query: 64 HQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVT-QTLYGLQYLHE 122
H NIV+Y GF + ++ I LEY + GS+ L++ E+ V +V+ Q LYGL YLH
Sbjct: 889 HLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQVLYGLSYLHS 948
Query: 123 QGVIHRDIKAANLLLTEEGIVKLADFGVSTRI-----NRMAMTYAGSPNWMAPEVMTG-- 175
+G+IHRD+KA NLL+ +G+ K++DFG+S N ++ GS WMAPEV+
Sbjct: 949 KGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLSMQGSIFWMAPEVIHNDH 1008
Query: 176 QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL------TLSAECK 229
QG S D+WSLG V+E+L G P+ A + + E+ PP+ +S E
Sbjct: 1009 QGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELVSQVSPEAI 1068
Query: 230 DFLSRCFQKNMFKRATAQELLAHIWLK 256
FL+ CF N R TA+ELL H ++K
Sbjct: 1069 QFLNACFTVNADVRPTAEELLNHPFMK 1095
>7300559 [T] KOG4279 Serine/threonine protein kinase
Length = 1310
Score = 159 bits (401), Expect = 2e-38
Identities = 104/263 (39%), Positives = 150/263 (56%), Gaps = 15/263 (5%)
Query: 13 KQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRG 72
K V+G+G YG VY A + T AIK++ ++ ++ EI L LRH+NIV Y G
Sbjct: 582 KMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLG 641
Query: 73 FIQKAHELYIILEYCARGSLRDIL--KHGPLLEDDTVN--YVTQTLYGLQYLHEQGVIHR 128
+ I +E GSL D+L K GPL ++++ Y Q L GL+YLHEQ ++HR
Sbjct: 642 SCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHR 701
Query: 129 DIKAANLLL-TEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVMTG--QGASTVS 182
DIK N+L+ T G+VK++DFG S RIN M T+ G+ +MAPEV+ +G +
Sbjct: 702 DIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAA 761
Query: 183 DIWSLGATVVELLTGNPPFHNLVN-ESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKN 239
DIWS G T VE+ TG PPF L + +A + + + P P LSA K+F+ RCF +
Sbjct: 762 DIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAIS 821
Query: 240 MFKRATAQELLAHIWLKKIQKPK 262
+ R +A +LL +L+ KP+
Sbjct: 822 VMDRPSASQLLEDPFLQ--DKPR 842
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 158 bits (400), Expect = 3e-38
Identities = 98/263 (37%), Positives = 144/263 (54%), Gaps = 8/263 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y + IG+GA G V+ A + AIKQI + + + + EI ++K L++ NIV
Sbjct: 249 YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN 308
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYV-TQTLYGLQYLHEQGVIHR 128
+ EL++++EY A GSL D++ +++ + V + L L++LH VIHR
Sbjct: 309 FLDSYLVGDELFVVMEYLAGGSLTDVVTETACMDEAQIAAVCRECLQALEFLHANQVIHR 368
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTVSDIW 185
DIK+ N+LL EG VKL DFG +I T G+P WMAPEV+T + DIW
Sbjct: 369 DIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIW 428
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFK 242
SLG +E++ G PP+ N A Y I E P LS +DFL+RC + ++ K
Sbjct: 429 SLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEK 488
Query: 243 RATAQELLAHIWLKKIQKPKSKI 265
R +A+ELL H +L K+ KP S +
Sbjct: 489 RGSAKELLQHPFL-KLAKPLSSL 510
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 157 bits (398), Expect = 5e-38
Identities = 89/266 (33%), Positives = 147/266 (54%), Gaps = 24/266 (9%)
Query: 19 GAYGVVYRAVKRGTNKPCAIKQIEFEDE----SELNEHMLEIDLLKNLRHQNIVEYRGFI 74
G +G VY V T A+K+I+ +D S +++ E+ +L+ L H N+V Y G
Sbjct: 1046 GMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVE 1105
Query: 75 QKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGLQYLHEQGVIHRDIKAA 133
++YI +E+C GSL D+L HG + +++ + YV Q L GL Y+H Q ++HRDIK A
Sbjct: 1106 VHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPA 1165
Query: 134 NLLLTEEGIVKLADFGVSTRINRMA-------------MTYAGSPNWMAPEVMTG--QGA 178
N+LL G++K +DFG + ++ AG+P +MAPE++ G +G
Sbjct: 1166 NILLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGD 1225
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL----TLSAECKDFLSR 234
DIWSLG ++E++TG+ P+ + NE A V + P + +S+ +DF+ +
Sbjct: 1226 FGAMDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQ 1285
Query: 235 CFQKNMFKRATAQELLAHIWLKKIQK 260
CF+++ +R A +LL H W+ +K
Sbjct: 1286 CFERDPEQRPRAVDLLTHPWITDFRK 1311
>Hs5174547 [T] KOG4279 Serine/threonine protein kinase
Length = 1374
Score = 157 bits (398), Expect = 5e-38
Identities = 100/261 (38%), Positives = 151/261 (57%), Gaps = 13/261 (4%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFI 74
V+G+G YG+VY AIK+I D EI L K+L+H+NIV+Y G
Sbjct: 685 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF 744
Query: 75 QKAHELYIILEYCARGSLRDIL--KHGPLLEDD-TVNYVT-QTLYGLQYLHEQGVIHRDI 130
+ + I +E GSL +L K GPL +++ T+ + T Q L GL+YLH+ ++HRDI
Sbjct: 745 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 804
Query: 131 KAANLLL-TEEGIVKLADFGVSTR---INRMAMTYAGSPNWMAPEVMT--GQGASTVSDI 184
K N+L+ T G++K++DFG S R IN T+ G+ +MAPE++ +G +DI
Sbjct: 805 KGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADI 864
Query: 185 WSLGATVVELLTGNPPFHNLVN-ESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKNMF 241
WSLG T++E+ TG PPF+ L ++A + + + P P ++SAE K F+ +CF+ +
Sbjct: 865 WSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPD 924
Query: 242 KRATAQELLAHIWLKKIQKPK 262
KRA A +LL +LK K K
Sbjct: 925 KRACANDLLVDEFLKVSSKKK 945
>Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 527
Score = 157 bits (398), Expect = 5e-38
Identities = 108/296 (36%), Positives = 150/296 (50%), Gaps = 34/296 (11%)
Query: 4 SIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNL 62
SI Y L++VIG GA VV A + AIK+I E ++ ++E + EI +
Sbjct: 11 SINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQC 70
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKH---------GPLLEDDTVNYVTQT 113
H NIV Y EL+++++ + GS+ DI+KH G L E + +
Sbjct: 71 HHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREV 130
Query: 114 LYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRI--------NRMAMTYAGSP 165
L GL+YLH+ G IHRD+KA N+LL E+G V++ADFGVS + N++ T+ G+P
Sbjct: 131 LEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTP 190
Query: 166 NWMAPEVMTG-QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL 224
WMAPEVM +G +DIWS G T +EL TG P+H + + P L
Sbjct: 191 CWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPSLET 249
Query: 225 SAECKDFL-----------SRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAE 269
+ K+ L S C QK+ KR TA ELL H K QK K+K L E
Sbjct: 250 GVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRH---KFFQKAKNKEFLQE 302
>SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase
Length = 312
Score = 157 bits (397), Expect = 6e-38
Identities = 109/306 (35%), Positives = 159/306 (51%), Gaps = 14/306 (4%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-EIDLLKNLRHQNIVEYRG 72
Q+IG+G++G V+RA ++K A+K ++ + + E + EI+ L +L +I +Y
Sbjct: 10 QLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHITKYYA 69
Query: 73 FIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIK 131
L+I +EYC GS D+LK G E + Q L L YLH QG +HRDIK
Sbjct: 70 SFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDIK 129
Query: 132 AANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMTGQGASTVSDIWSLG 188
AAN+L ++G+VKLADFGVS ++ + + G+P WMAPEV+ G + +DIWSLG
Sbjct: 130 AANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVVKQTGYNYKADIWSLG 189
Query: 189 ATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLS----AECKDFLSRCFQKNMFKRA 244
T EL TG PP+ ++ ++ + P L S A C DF+S C +KN RA
Sbjct: 190 ITAYELATGEPPYSG-IHPMKVLLLIPKHSPPSLERSKFSRAFC-DFVSNCLKKNPKDRA 247
Query: 245 TAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMTPSPTKSPIQEDLAP 304
TA+ L H ++KK S + E + KW +L T + S D
Sbjct: 248 TAEYLSKHKFIKKYCPNTS---VKEVVASYAKWKESELLPEATPYNSTMGNSANTIDEVV 304
Query: 305 ADFRTL 310
DF T+
Sbjct: 305 WDFGTV 310
>Hs4758702 [T] KOG4279 Serine/threonine protein kinase
Length = 1011
Score = 157 bits (397), Expect = 6e-38
Identities = 103/262 (39%), Positives = 153/262 (58%), Gaps = 13/262 (4%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFI 74
V+G+G YGVVY R T AIK+I D EI L + LRH+NIV Y G
Sbjct: 376 VLGKGTYGVVYAGRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSA 435
Query: 75 QKAHELYIILEYCARGSLRDILKH--GPLLEDD-TVNYVT-QTLYGLQYLHEQGVIHRDI 130
+ L I +E GSL +L+ GPL +++ T+++ T Q L GL YLH+ ++HRDI
Sbjct: 436 SQGGYLKIFMEEVPGGSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDI 495
Query: 131 KAANLLL-TEEGIVKLADFGVSTR---INRMAMTYAGSPNWMAPEVMT--GQGASTVSDI 184
K N+L+ T G++K++DFG S R I T+ G+ +MAPE++ +G +DI
Sbjct: 496 KGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADI 555
Query: 185 WSLGATVVELLTGNPPFHNLVN-ESACYAIVNEEYIPPL--TLSAECKDFLSRCFQKNMF 241
WSLG TV+E+ TG PPFH L + ++A + + + PP+ +LSAE + FL R F+ +
Sbjct: 556 WSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPR 615
Query: 242 KRATAQELLAHIWLKKIQKPKS 263
RA+AQ LL +L+ ++ +S
Sbjct: 616 LRASAQTLLGDPFLQPGKRSRS 637
>At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 422
Score = 157 bits (397), Expect = 6e-38
Identities = 100/250 (40%), Positives = 144/250 (57%), Gaps = 16/250 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDE-SELNEHMLEID----LLKNLRHQNIV 68
Q++GRG+ G VY + + A K++ D+ S+ +E + +++ LL L+HQNIV
Sbjct: 157 QLLGRGSLGSVYEGISADGDF-FAFKEVSLLDQGSQAHEWIQQVEGGIALLSQLQHQNIV 215
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
YRG + LYI LE +GSLR + + L + Y Q L GL+YLH++G IHR
Sbjct: 216 RYRGTTKDESNLYIFLELVTQGSLRKLYQRNQLGDSVVSLYTRQILDGLKYLHDKGFIHR 275
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTG----QGASTVSDI 184
+IK AN+L+ G VKLADFG++ ++ Y NWMAPEV+ G T +DI
Sbjct: 276 NIKCANVLVDANGTVKLADFGLAKVMSLWRTPYW---NWMAPEVILNPKDYDGYGTPADI 332
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKNMFK 242
WSLG TV+E+LTG P+ +L +A Y I + +P P LS + +DF+ C + N +
Sbjct: 333 WSLGCTVLEMLTGQIPYSDLEIGTALYNIGTGK-LPKIPDILSLDARDFILTCLKVNPEE 391
Query: 243 RATAQELLAH 252
R TA ELL H
Sbjct: 392 RPTAAELLNH 401
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 156 bits (394), Expect = 1e-37
Identities = 89/264 (33%), Positives = 142/264 (53%), Gaps = 9/264 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y Q +G+GA G+V+ A A+K I+ +++S + + EI +LK+ H+N+V
Sbjct: 293 YKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVN 352
Query: 70 YRG--FIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIH 127
+ ++ +L++++EY G L D++ + E +TLY + +LH +G+IH
Sbjct: 353 FLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIH 412
Query: 128 RDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQGASTVSDIW 185
RDIK+ N+LL +G VK+ DFG I + T G+P WMAPEV+T + DIW
Sbjct: 413 RDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIW 472
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL----TLSAECKDFLSRCFQKNMF 241
S+G +E++ G PP+ A Y I P + LS +DFL RC Q +
Sbjct: 473 SIGIMAIEMIEGQPPYLYETPLRALYLIAANGR-PDIKSWDKLSPNLQDFLDRCLQVEVD 531
Query: 242 KRATAQELLAHIWLKKIQKPKSKI 265
+RATA ELL+H +L + K+ +
Sbjct: 532 RRATADELLSHPFLNDCSEVKALV 555
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 155 bits (393), Expect = 2e-37
Identities = 101/269 (37%), Positives = 146/269 (53%), Gaps = 17/269 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEF---EDESELNEHMLEIDLLKNLRHQNIVEYRG 72
IG G++G VY A T + AIK++ + + + + + + EI L+ L H N +EY+G
Sbjct: 33 IGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLNHPNTIEYKG 92
Query: 73 FIQKAHELYIILEYCARGSLRDILK--HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDI 130
+ ++++EYC GS DI++ PL ED+ L GL YLH G IHRDI
Sbjct: 93 CYLRESTAWLVMEYCV-GSASDIIEVHKKPLHEDEIAAICLGVLSGLSYLHSLGRIHRDI 151
Query: 131 KAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVM----TGQGASTVSDIWS 186
KA N+LLT+ G+VKLADFG S I A ++ G+P WMAPEV+ GQ V D+WS
Sbjct: 152 KAGNILLTDNGVVKLADFG-SAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKV-DVWS 209
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNEE--YIPPLTLSAECKDFLSRCFQKNMFKRA 244
LG T +EL PP+ N+ SA Y I E +P S F+ C +K +R
Sbjct: 210 LGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKMPAERP 269
Query: 245 TAQELLAHIWLKKIQKPKSKINLAEYIEK 273
++ +LL H + + +P+S L E I +
Sbjct: 270 SSAKLLTHAY---VTRPRSDTVLLELIAR 295
>Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 820
Score = 155 bits (391), Expect = 3e-37
Identities = 95/255 (37%), Positives = 137/255 (53%), Gaps = 12/255 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
+ L Q +G G YG VY+A T++ A+K ++ + +++ EI +L+ RH N+V
Sbjct: 16 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVA 75
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYV-TQTLYGLQYLHEQGVIHR 128
Y G + L+I +E+C GSL++I LE+ + YV + L GL +LH QG IHR
Sbjct: 76 YIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHR 135
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMTGQ---GASTVS 182
DIK ANLLLT +G VKLADFGVS + ++ G+P WMAPEV + G + +
Sbjct: 136 DIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELC 195
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPP-----LTLSAECKDFLSRCFQ 237
D+W+LG T +EL PP +L A + + PP + FL
Sbjct: 196 DVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALT 255
Query: 238 KNMFKRATAQELLAH 252
KN KR TA++LL H
Sbjct: 256 KNPKKRPTAEKLLQH 270
>7296450 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 769
Score = 155 bits (391), Expect = 3e-37
Identities = 83/256 (32%), Positives = 142/256 (55%), Gaps = 8/256 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE---FEDESELNEHMLEIDLLKNLRHQN 66
Y ++ ++G+G + VY+A T++ AIK I+ + N E+++ L+H +
Sbjct: 14 YEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPS 73
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKH--GPLLEDDTVNYVTQTLYGLQYLHEQG 124
+++ F Q A+ +Y++LE G L + H P E + + + Q + GL YLH
Sbjct: 74 VLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHN 133
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGASTV 181
++HRDI +NLLL+ E VK+ADFG++T++ R MT G+PN+++PEV++
Sbjct: 134 IMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLP 193
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
+D+WS+G + LL G PPF +S +V EYI P LS E +D +++ +K
Sbjct: 194 ADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPH 253
Query: 242 KRATAQELLAHIWLKK 257
+R T + +L H ++ K
Sbjct: 254 ERITLEAVLCHPFMLK 269
>HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 819
Score = 154 bits (390), Expect = 4e-37
Identities = 95/255 (37%), Positives = 137/255 (53%), Gaps = 12/255 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
+ L Q +G G YG VY+A T++ A+K ++ + +++ EI +L+ RH N+V
Sbjct: 15 FELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHPNVVA 74
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYV-TQTLYGLQYLHEQGVIHR 128
Y G + L+I +E+C GSL++I LE+ + YV + L GL +LH QG IHR
Sbjct: 75 YIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCRERLKGLHHLHSQGKIHR 134
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMTGQ---GASTVS 182
DIK ANLLLT +G VKLADFGVS + ++ G+P WMAPEV + G + +
Sbjct: 135 DIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELC 194
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPP-----LTLSAECKDFLSRCFQ 237
D+W+LG T +EL PP +L A + + PP + FL
Sbjct: 195 DVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALT 254
Query: 238 KNMFKRATAQELLAH 252
KN KR TA++LL H
Sbjct: 255 KNPKKRPTAEKLLQH 269
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 154 bits (388), Expect = 7e-37
Identities = 102/260 (39%), Positives = 142/260 (54%), Gaps = 13/260 (5%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-EIDLLKNLRHQNIV 68
Y+++ IGRG +G VY+AV R T + AIK + E E E + EI L L+ I
Sbjct: 18 YSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLIT 77
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPL--LEDDTVNYVT-QTLYGLQYLHEQGV 125
Y + + ++I++EYC GS D+LK + L ++ V+++ + GL+YLHEQ
Sbjct: 78 NYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRK 137
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM--TYAGSPNWMAPEVMTGQ--GASTV 181
IHRDIKAAN+LL EEG+VKL DFGVS I T+ G+P WMAPEV+ + G +
Sbjct: 138 IHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDTFVGTPYWMAPEVVCCEVDGYNEK 197
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL---TLSAECKDFLSRCFQK 238
+DIWSLG T ELL G PP + + PP S KDF++ C K
Sbjct: 198 ADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRK--PPKLQGPFSDAAKDFVAGCLVK 255
Query: 239 NMFKRATAQELLAHIWLKKI 258
R +A LL+ ++K I
Sbjct: 256 TPADRPSAYNLLSFEFVKNI 275
>At4g08470 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 560
Score = 153 bits (387), Expect = 9e-37
Identities = 97/251 (38%), Positives = 142/251 (55%), Gaps = 15/251 (5%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNLRHQNIV 68
Q++GRG+Y VY A+ + A+K++ D+ + + EI LL L+HQNIV
Sbjct: 307 QLLGRGSYASVYEAISEDGDF-FAVKEVSLLDKGIQAQECIQQLEGEIALLSQLQHQNIV 365
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
YRG + +LYI LE +GS++ + + L Y Q L GL YLH++G +HR
Sbjct: 366 RYRGTAKDVSKLYIFLELVTQGSVQKLYERYQLSYTVVSLYTRQILAGLNYLHDKGFVHR 425
Query: 129 DIKAANLLLTEEGIVKLADFGV--STRINRMAMTYAGSPNWMAPEVMT---GQGASTVSD 183
DIK AN+L+ G VKLADFG+ +++ N + M+ G+ WMAPEV+ G + +D
Sbjct: 426 DIKCANMLVDANGTVKLADFGLAEASKFNDI-MSCKGTLFWMAPEVINRKDSDGNGSPAD 484
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKNMF 241
IWSLG TV+E+ TG P+ +L A + I +P P TLS + + F+ C + N
Sbjct: 485 IWSLGCTVLEMCTGQIPYSDLKPIQAAFKI-GRGTLPDVPDTLSLDARHFILTCLKVNPE 543
Query: 242 KRATAQELLAH 252
+R TA ELL H
Sbjct: 544 ERPTAAELLHH 554
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 153 bits (387), Expect = 9e-37
Identities = 99/293 (33%), Positives = 155/293 (52%), Gaps = 13/293 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEF-EDESELNEHMLEIDLLKNLRHQNIV 68
Y +G+G+YG VY+A T++ A+K I E E E EI++L+ H N+V
Sbjct: 249 YEFLNELGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEMLQQCNHPNVV 308
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVT-QTLYGLQYLHEQGVI 126
Y G Q L+I++EYC GS+ D++ LE+ + Y+ + L GL YLH +
Sbjct: 309 RYLGSYQGEDYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREALKGLAYLHSIYKV 368
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRINRMAM---TYAGSPNWMAPEVMTGQGASTVSD 183
HRDIK N+LLTE+G VKL DFGV+ ++ R T+ G+P+WMAPEV+ D
Sbjct: 369 HRDIKGGNILLTEQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQENRYDGKVD 428
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL----TLSAECKDFLSRCFQKN 239
+W+LG + +E+ G PP + V+ +++ E P L S DF+++C K
Sbjct: 429 VWALGVSAIEMAEGLPP-RSSVHPMRVLFMISIEPAPMLEDKEKWSLVFHDFVAKCLTKE 487
Query: 240 MFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMTPS 292
R TA E+L H ++++ + S ++ IEK + L + + + PS
Sbjct: 488 PRLRPTAAEMLKHKFVERCKTGASA--MSPKIEKSRQIRATMALQAQSVVAPS 538
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 153 bits (386), Expect = 1e-36
Identities = 93/258 (36%), Positives = 140/258 (54%), Gaps = 21/258 (8%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML--------EIDLLKNLRHQN 66
+IG G++G VY + + + A+KQ+ + SE + EI LL+ L H++
Sbjct: 102 LIGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEH 161
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
IV+Y G + L I LEY GS+ +L +G E N++ QTL GL+YLH +G+
Sbjct: 162 IVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHSRGI 221
Query: 126 IHRDIKAANLLLTEEGIVKLADFGV---------STRINRMAMTYAGSPNWMAPEVMTGQ 176
+HRDIK AN+L+ +G +K++DFG+ ST+ ++ GS WMAPEV+
Sbjct: 222 VHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQT 281
Query: 177 GASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSR 234
+ +DIWSLG V+E+LT P+ N A + I E +P P +S+ DFL +
Sbjct: 282 MHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRI-GENILPEFPSNISSSAIDFLEK 340
Query: 235 CFQKNMFKRATAQELLAH 252
F + R TA ELL+H
Sbjct: 341 TFAIDCNLRPTASELLSH 358
>HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1165
Score = 153 bits (386), Expect = 1e-36
Identities = 102/293 (34%), Positives = 163/293 (54%), Gaps = 28/293 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNL-RHQN 66
G + L +V+G G YG VY+ T + AIK ++ ++ E E LEI++LK H+N
Sbjct: 23 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSHHRN 81
Query: 67 IVEYRG-FIQKA-----HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLYGL 117
I Y G FI+K+ +L++++E+C GS+ D++K+ G L++D + Y++ + L GL
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMT 174
+LH VIHRDIK N+LLTE VKL DFGVS +++R T+ G+P WMAPEV+
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 175 GQGASTV-----SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL----- 224
SD+WS G T +E+ G PP ++ A + I PP L
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN---PPPRLKSKKW 258
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLK-KIQKPKSKINLAEYIEKDGK 276
S + F+ C KN +R + ++LL H +++ + + + +I L ++I++ K
Sbjct: 259 SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK 311
>Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1212
Score = 153 bits (386), Expect = 1e-36
Identities = 102/293 (34%), Positives = 163/293 (54%), Gaps = 28/293 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNL-RHQN 66
G + L +V+G G YG VY+ T + AIK ++ ++ E E LEI++LK H+N
Sbjct: 23 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSHHRN 81
Query: 67 IVEYRG-FIQKA-----HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLYGL 117
I Y G FI+K+ +L++++E+C GS+ D++K+ G L++D + Y++ + L GL
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMT 174
+LH VIHRDIK N+LLTE VKL DFGVS +++R T+ G+P WMAPEV+
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 175 GQGASTV-----SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL----- 224
SD+WS G T +E+ G PP ++ A + I PP L
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN---PPPRLKSKKW 258
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLK-KIQKPKSKINLAEYIEKDGK 276
S + F+ C KN +R + ++LL H +++ + + + +I L ++I++ K
Sbjct: 259 SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK 311
>Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1320
Score = 153 bits (386), Expect = 1e-36
Identities = 102/293 (34%), Positives = 163/293 (54%), Gaps = 28/293 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNL-RHQN 66
G + L +V+G G YG VY+ T + AIK ++ ++ E E LEI++LK H+N
Sbjct: 23 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSHHRN 81
Query: 67 IVEYRG-FIQKA-----HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLYGL 117
I Y G FI+K+ +L++++E+C GS+ D++K+ G L++D + Y++ + L GL
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMT 174
+LH VIHRDIK N+LLTE VKL DFGVS +++R T+ G+P WMAPEV+
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 175 GQGASTV-----SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL----- 224
SD+WS G T +E+ G PP ++ A + I PP L
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN---PPPRLKSKKW 258
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLK-KIQKPKSKINLAEYIEKDGK 276
S + F+ C KN +R + ++LL H +++ + + + +I L ++I++ K
Sbjct: 259 SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK 311
>Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1166
Score = 153 bits (386), Expect = 1e-36
Identities = 102/293 (34%), Positives = 163/293 (54%), Gaps = 28/293 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNL-RHQN 66
G + L +V+G G YG VY+ T + AIK ++ ++ E E LEI++LK H+N
Sbjct: 23 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKLEINMLKKYSHHRN 81
Query: 67 IVEYRG-FIQKA-----HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLYGL 117
I Y G FI+K+ +L++++E+C GS+ D++K+ G L++D + Y++ + L GL
Sbjct: 82 IATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGL 141
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMT 174
+LH VIHRDIK N+LLTE VKL DFGVS +++R T+ G+P WMAPEV+
Sbjct: 142 AHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 175 GQGASTV-----SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL----- 224
SD+WS G T +E+ G PP ++ A + I PP L
Sbjct: 202 CDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN---PPPRLKSKKW 258
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLK-KIQKPKSKINLAEYIEKDGK 276
S + F+ C KN +R + ++LL H +++ + + + +I L ++I++ K
Sbjct: 259 SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRK 311
>Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 833
Score = 152 bits (385), Expect = 1e-36
Identities = 92/255 (36%), Positives = 139/255 (54%), Gaps = 12/255 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y L Q +G G YG V++A + + A+K ++ E + +++ EI +LK RH NIV
Sbjct: 17 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVA 76
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYV-TQTLYGLQYLHEQGVIHR 128
Y G +L+I +E+C GSL+DI + L + ++YV + L GL YLH Q IHR
Sbjct: 77 YHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHR 136
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMT---GQGASTVS 182
DIK AN+L+ + G V+LADFG+S +I +++ G+P WMAPEV G + +
Sbjct: 137 DIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELC 196
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL-----TLSAECKDFLSRCFQ 237
DIWSLG T +EL PP ++ + + Y PP SA +F+
Sbjct: 197 DIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLT 256
Query: 238 KNMFKRATAQELLAH 252
K+ KR +A ++L+H
Sbjct: 257 KSPKKRPSATKMLSH 271
>Hs14771959 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 719
Score = 152 bits (384), Expect = 2e-36
Identities = 87/260 (33%), Positives = 139/260 (53%), Gaps = 10/260 (3%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
IG G+ G+V A ++ T K A+K+++ + E+ ++++ H N+V+
Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL 514
Query: 76 KAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANL 135
EL++++E+ G+L DI+ H + E+ L L YLH QGVIHRDIK+ ++
Sbjct: 515 VGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSI 574
Query: 136 LLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
LLT +G +KL+DFG ++++ + G+P WMAPEV++ T DIWSLG V+
Sbjct: 575 LLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVI 634
Query: 193 ELLTGNPPFHNLVNESACYAIVNEEYIPPLT-----LSAECKDFLSRCFQKNMFKRATAQ 247
E++ G PP+ N A I + +PP +S+ + FL + +RATAQ
Sbjct: 635 EMIDGEPPYFNEPPLQAMRRI--RDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQ 692
Query: 248 ELLAHIWLKKIQKPKSKINL 267
ELL H +LK P + L
Sbjct: 693 ELLGHPFLKLAGPPSCIVPL 712
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 152 bits (384), Expect = 2e-36
Identities = 89/253 (35%), Positives = 135/253 (53%), Gaps = 6/253 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y + IG+GA G VY A++ T AIKQ+ + + + EI +++ +H N+V
Sbjct: 430 YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVN 489
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRD 129
Y + EL++++EY GSL D++ + E + L L++LH VIHRD
Sbjct: 490 YLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRD 549
Query: 130 IKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQGASTVSDIWS 186
IK+ N+LL +G VKL DFG +I+ T G+P WMAPEV+T + D+WS
Sbjct: 550 IKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWS 609
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKR 243
LG +E++ G PP+ N A Y I E LS+ +DFL +C + + +R
Sbjct: 610 LGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRR 669
Query: 244 ATAQELLAHIWLK 256
A+A +LL H +LK
Sbjct: 670 ASALDLLKHPFLK 682
>CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 829
Score = 151 bits (382), Expect = 3e-36
Identities = 111/340 (32%), Positives = 163/340 (47%), Gaps = 28/340 (8%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y L Q +G G YG VY+A ++ A+K ++ E EI +++ H NI+
Sbjct: 15 YELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIMVIRECSHPNIIA 74
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
Y G + L+I++EYC GSL+DI GPL E +TL GL YLH G IHR
Sbjct: 75 YFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKIHR 134
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQ---GASTVS 182
DIK AN+LL+ G VKLADFGV+ +I ++ G+P WMAPEV + G
Sbjct: 135 DIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMQC 194
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAE-----CKDFLSRCFQ 237
D+W+ G T +EL PP +L Y + Y PP DF+ +C
Sbjct: 195 DVWATGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWTPLFHDFVRQCLT 254
Query: 238 KNMFKRATAQEL-------LAHIWLKKIQKPKSKINLA--EYIEKDGKWDVDFVLDSNTD 288
KN KR + ++L L + + + K+N A + ++ K VD + + +D
Sbjct: 255 KNPKKRPSPEKLLTSHPFVLGSLSARMTRDLLDKVNGAPTDVYDRMSK-TVDDLTEEESD 313
Query: 289 MTPSPT-----KSPIQEDLAPADFRTLSVDQLFIEHSTDS 323
M +P+ +PI+ L PA L +D +E + S
Sbjct: 314 MDDAPSLLTPDAAPIRIGL-PAHLNGLRLDARCLEQLSSS 352
>Hs7706401 [T] KOG0577 Serine/threonine protein kinase
Length = 1235
Score = 150 bits (379), Expect = 7e-36
Identities = 112/349 (32%), Positives = 176/349 (50%), Gaps = 28/349 (8%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEF---EDESELNEHMLEIDLLKNLRHQNIVEYRG 72
IG G++G VY A ++ AIK++ + + + + + E+ L+ LRH N ++YRG
Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 93
Query: 73 FIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQ-TLYGLQYLHEQGVIHRDI 130
+ H ++++EYC GS D+L+ H L++ + VT L GL YLH +IHRD+
Sbjct: 94 CYLREHTAWLVMEYCL-GSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDV 152
Query: 131 KAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVM----TGQGASTVSDIWS 186
KA N+LL+E G+VKL DFG S I A ++ G+P WMAPEV+ GQ V D+WS
Sbjct: 153 KAGNILLSEPGLVKLGDFG-SASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKV-DVWS 210
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAE----CKDFLSRCFQKNMFK 242
LG T +EL PP N+ SA Y I E P+ S ++F+ C QK
Sbjct: 211 LGITCIELAERKPPLFNMNAMSALYHIAQNE--SPVLQSGHWSEYFRNFVDSCLQKIPQD 268
Query: 243 RATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVD--------FVLDSNTDMTPSPT 294
R T++ LL H ++ + + P ++L + KD ++D +L P
Sbjct: 269 RPTSEVLLKHRFVLRERPPTVIMDLIQR-TKDAVRELDNLQYRKMKKILFQEAPNGPGAE 327
Query: 295 KSPIQEDLAPADFRTLSVDQLFIEHSTDSIVVGLIKTLNELTAIKADAT 343
+E+ P R ++ L HS S+ + + + ++ ADA+
Sbjct: 328 APEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSL-ADAS 375
>Hs4759208 [T] KOG0577 Serine/threonine protein kinase
Length = 1049
Score = 150 bits (379), Expect = 7e-36
Identities = 112/349 (32%), Positives = 176/349 (50%), Gaps = 28/349 (8%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEF---EDESELNEHMLEIDLLKNLRHQNIVEYRG 72
IG G++G VY A ++ AIK++ + + + + + E+ L+ LRH N ++YRG
Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRG 93
Query: 73 FIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQ-TLYGLQYLHEQGVIHRDI 130
+ H ++++EYC GS D+L+ H L++ + VT L GL YLH +IHRD+
Sbjct: 94 CYLREHTAWLVMEYCL-GSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDV 152
Query: 131 KAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVM----TGQGASTVSDIWS 186
KA N+LL+E G+VKL DFG S I A ++ G+P WMAPEV+ GQ V D+WS
Sbjct: 153 KAGNILLSEPGLVKLGDFG-SASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKV-DVWS 210
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAE----CKDFLSRCFQKNMFK 242
LG T +EL PP N+ SA Y I E P+ S ++F+ C QK
Sbjct: 211 LGITCIELAERKPPLFNMNAMSALYHIAQNE--SPVLQSGHWSEYFRNFVDSCLQKIPQD 268
Query: 243 RATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVD--------FVLDSNTDMTPSPT 294
R T++ LL H ++ + + P ++L + KD ++D +L P
Sbjct: 269 RPTSEVLLKHRFVLRERPPTVIMDLIQR-TKDAVRELDNLQYRKMKKILFQEAPNGPGAE 327
Query: 295 KSPIQEDLAPADFRTLSVDQLFIEHSTDSIVVGLIKTLNELTAIKADAT 343
+E+ P R ++ L HS S+ + + + ++ ADA+
Sbjct: 328 APEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSL-ADAS 375
>YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1579
Score = 149 bits (376), Expect = 2e-35
Identities = 100/296 (33%), Positives = 144/296 (47%), Gaps = 49/296 (16%)
Query: 13 KQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML----EIDLLKNLRHQNIV 68
+ IG G +G VY AV + A+K+I +D + + E+ +L+ L H NIV
Sbjct: 1269 RNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSKSMQKIFPLIKEEMSVLEILNHPNIV 1328
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN--YVTQTLYGLQYLHEQGVI 126
Y G ++ I +EYC GSL +L+HG + ED+ V Y Q L GL YLHE G++
Sbjct: 1329 SYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRI-EDEMVTQVYTLQLLEGLAYLHESGIV 1387
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRI----NRMA------------------------ 158
HRD+K N+LL G++K DFG + +I R+A
Sbjct: 1388 HRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADGEHEDVTHVSDSKAV 1447
Query: 159 -------MTYAGSPNWMAPEVMTG---QGASTVSDIWSLGATVVELLTGNPPFHNLVNES 208
+ G+P +MAPE +TG +G D+WSLG V+E++TG P+ NL NE
Sbjct: 1448 KNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNEW 1507
Query: 209 ACYAIVNEEYIPPLTLSAECKD----FLSRCFQKNMFKRATAQELLAHIWLKKIQK 260
A V + P E FL RC +N KRA+A ELL W+ +I++
Sbjct: 1508 AIMYHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVELLMDPWIVQIRE 1563
>YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1331
Score = 149 bits (376), Expect = 2e-35
Identities = 100/280 (35%), Positives = 145/280 (51%), Gaps = 33/280 (11%)
Query: 13 KQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML----EIDLLKNLRHQNIV 68
+ IG G +G VY A+ + A+K+I+ D + + + E+ +L+ L H NIV
Sbjct: 1037 RSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIV 1096
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN--YVTQTLYGLQYLHEQGVI 126
+Y G ++ I +EYC GSL +L HG + ED+ V Y + L GL YLH+ GV+
Sbjct: 1097 QYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRI-EDEMVTQVYTFELLEGLAYLHQSGVV 1155
Query: 127 HRDIKAANLLLTEEGIVKLADFGVS-------TRINRMAMT------------YAGSPNW 167
HRDIK N+LL GI+K DFG + TR R A G+P +
Sbjct: 1156 HRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMY 1215
Query: 168 MAPEVMTG---QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL-- 222
MAPE ++G +G D+W+LG V+E+ TG P+ NL NE A V IP L
Sbjct: 1216 MAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPN 1275
Query: 223 --TLSAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQK 260
++A + FL RC ++ RATA ELL W+ +I++
Sbjct: 1276 RDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWMIQIRE 1315
>Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 149 bits (376), Expect = 2e-35
Identities = 103/295 (34%), Positives = 148/295 (49%), Gaps = 34/295 (11%)
Query: 5 IAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLR 63
I Y L++VIG GA VV A+ + + AIK+I E ++ ++E + EI +
Sbjct: 60 ICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCS 119
Query: 64 HQNIVEYRGFIQKAHELYIILEYCARGSLRDILKH---------GPLLEDDTVNYVTQTL 114
H N+V Y EL+++++ + GS+ DI+K+ G L E + + L
Sbjct: 120 HPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVL 179
Query: 115 YGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRI--------NRMAMTYAGSPN 166
GL YLH G IHRD+KA N+LL E+G V++ADFGVS + N++ T+ G+P
Sbjct: 180 EGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPC 239
Query: 167 WMAPEVMTG-QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLS 225
WMAPEVM +G +D+WS G T +EL TG P+H + + P L
Sbjct: 240 WMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPTLETG 298
Query: 226 AECKD-----------FLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAE 269
E K+ LS C QK+ KR TA ELL K QK K++ L E
Sbjct: 299 VEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK---CKFFQKAKNREYLIE 350
>Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1295
Score = 149 bits (375), Expect = 2e-35
Identities = 102/293 (34%), Positives = 159/293 (53%), Gaps = 28/293 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNL-RHQN 66
G + L +V+G G YG VY+ T + AIK ++ ++ E E EI++LK H+N
Sbjct: 23 GIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-EEIKQEINMLKKYSHHRN 81
Query: 67 IVEYRG-FIQKA-----HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLYGL 117
I Y G FI+K+ +L++++E+C GS+ D++K+ G L++D + Y+ + L GL
Sbjct: 82 IATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGL 141
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMT 174
+LH VIHRDIK N+LLTE VKL DFGVS +++R T+ G+P WMAPEV+
Sbjct: 142 AHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIA 201
Query: 175 GQGASTV-----SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL----- 224
SDIWSLG T +E+ G PP ++ A + I PP L
Sbjct: 202 CDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN---PPPRLKSKKW 258
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLK-KIQKPKSKINLAEYIEKDGK 276
S + DF+ C K R ++LL +++ + + + +I L ++I++ K
Sbjct: 259 SKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRK 311
>Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 591
Score = 148 bits (374), Expect = 3e-35
Identities = 88/260 (33%), Positives = 139/260 (52%), Gaps = 10/260 (3%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
IG G+ G+V A R + K A+K+++ + E+ ++++ +H+N+VE
Sbjct: 327 IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYL 386
Query: 76 KAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANL 135
EL++++E+ G+L DI+ H + E+ L L LH QGVIHRDIK+ ++
Sbjct: 387 VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSI 446
Query: 136 LLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
LLT +G VKL+DFG ++++ + G+P WMAPE+++ DIWSLG V+
Sbjct: 447 LLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVI 506
Query: 193 ELLTGNPPFHNLVNESACYAIVNEEYIPPL-----TLSAECKDFLSRCFQKNMFKRATAQ 247
E++ G PP+ N A I + +PP +S K FL R ++ +RATA
Sbjct: 507 EMVDGEPPYFNEPPLKAMKMI--RDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAA 564
Query: 248 ELLAHIWLKKIQKPKSKINL 267
ELL H +L K P S + L
Sbjct: 565 ELLKHPFLAKAGPPASIVPL 584
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 147 bits (372), Expect = 5e-35
Identities = 102/290 (35%), Positives = 146/290 (50%), Gaps = 20/290 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G GA+G VY+A + + A K + EDE L++HM+EID+L ++H NIVE
Sbjct: 43 LGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMVEIDILSEIKHPNIVELYEAFS 102
Query: 76 KAHELYIILEYCARGSLRDIL--KHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
+L++++EYC G+L I+ PL E GL +LH VIHRD+KA
Sbjct: 103 IDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAG 162
Query: 134 NLLLTEEGIVKLADFGVSTRINRMAM----TYAGSPNWMAPEVM-----TGQGASTVSDI 184
N+LLT EG VKLADFGVS + N+ M T+ G+P WMAPE++ DI
Sbjct: 163 NVLLTMEGGVKLADFGVSAK-NKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDI 221
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEE---YIPPLTLSAECKDFLSRCFQKNMF 241
WSLG T++EL PP + I E P S E DFL + K+
Sbjct: 222 WSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQ 281
Query: 242 KRATAQELLAHIWL-KKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMT 290
R T L+ H ++ + + K L EY + V+ V+D T+++
Sbjct: 282 VRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAE----VVEEVVDDETEVS 327
>Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 681
Score = 147 bits (371), Expect = 6e-35
Identities = 90/267 (33%), Positives = 144/267 (53%), Gaps = 12/267 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
IG G+ G+V A ++ + + A+K ++ + E+ ++++ +H N+VE
Sbjct: 413 IGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYL 472
Query: 76 KAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANL 135
EL++++E+ G+L DI+ L E+ L L YLH QGVIHRDIK+ ++
Sbjct: 473 VGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSI 532
Query: 136 LLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
LLT +G VKL+DFG +I++ + G+P WMAPEV++ +T DIWSLG V+
Sbjct: 533 LLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVI 592
Query: 193 ELLTGNPPFHNLVNESACYAIVNEEYIPPLTL------SAECKDFLSRCFQKNMFKRATA 246
E++ G PP+ ++S A+ PP L S +DFL R ++ +RATA
Sbjct: 593 EMVDGEPPY---FSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATA 649
Query: 247 QELLAHIWLKKIQKPKSKINLAEYIEK 273
QELL H +L + P+ + L + K
Sbjct: 650 QELLDHPFLLQTGLPECLVPLIQLYRK 676
>CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 378
Score = 147 bits (371), Expect = 6e-35
Identities = 89/264 (33%), Positives = 140/264 (52%), Gaps = 7/264 (2%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNI 67
G Y +K+ IG GA G V+ A G+ A+K++ F+ + + + EI ++K RH N+
Sbjct: 106 GKYEMKKQIGVGASGTVFVANVAGSTDVVAVKRMAFKTQPKKEMLLTEIKVMKQYRHPNL 165
Query: 68 VEY-RGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
V Y ++ A +L+++++Y G+L D++ L E + + L L +LH ++
Sbjct: 166 VNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIV 225
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRINRMAM--TYAGSPNWMAPEVMTGQGASTVSDI 184
HRDIK+ N+LL G VKL D G +I + T G+P WM+PE++ + + DI
Sbjct: 226 HRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYNYKVDI 285
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMF 241
WSLG +E++ G PP+ A Y I E LS+E +FL +C +
Sbjct: 286 WSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPD 345
Query: 242 KRATAQELLAHIWLKKIQKPKSKI 265
+RA ELLAH +LKK KP S +
Sbjct: 346 QRADTTELLAHPFLKK-AKPLSSL 368
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 147 bits (371), Expect = 6e-35
Identities = 98/274 (35%), Positives = 145/274 (52%), Gaps = 25/274 (9%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE-FEDESELNEHMLEIDLLKNLR-HQN 66
T+ + + IG+G YG V++ + + + A+K ++ D E E E ++LK L H N
Sbjct: 20 TWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDE--EIEAEYNILKALSDHPN 77
Query: 67 IVEYRGFIQK-----AHELYIILEYCARGSLRDI----LKHGPLLEDDTVNYVT-QTLYG 116
+V + G K +L+++LE C+ GS+ D+ LK G + + + Y+ + L G
Sbjct: 78 VVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMG 137
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVM 173
LQ+LH IHRD+K N+LLT EG VKL DFGVS T T G+P WMAPEV+
Sbjct: 138 LQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVI 197
Query: 174 TGQGASTVS-----DIWSLGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLS 225
+ + D WSLG T +EL G+PP +L A + I + P S
Sbjct: 198 ACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWS 257
Query: 226 AECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQ 259
AE DF+S+C K+ KR T ELL H ++ +I+
Sbjct: 258 AEFNDFISKCLTKDYEKRPTVSELLQHKFITQIE 291
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 147 bits (371), Expect = 6e-35
Identities = 98/274 (35%), Positives = 145/274 (52%), Gaps = 25/274 (9%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE-FEDESELNEHMLEIDLLKNLR-HQN 66
T+ + + IG+G YG V++ + + + A+K ++ D E E E ++LK L H N
Sbjct: 20 TWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDE--EIEAEYNILKALSDHPN 77
Query: 67 IVEYRGFIQK-----AHELYIILEYCARGSLRDI----LKHGPLLEDDTVNYVT-QTLYG 116
+V + G K +L+++LE C+ GS+ D+ LK G + + + Y+ + L G
Sbjct: 78 VVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMG 137
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVM 173
LQ+LH IHRD+K N+LLT EG VKL DFGVS T T G+P WMAPEV+
Sbjct: 138 LQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVI 197
Query: 174 TGQGASTVS-----DIWSLGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLS 225
+ + D WSLG T +EL G+PP +L A + I + P S
Sbjct: 198 ACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWS 257
Query: 226 AECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQ 259
AE DF+S+C K+ KR T ELL H ++ +I+
Sbjct: 258 AEFNDFISKCLTKDYEKRPTVSELLQHKFITQIE 291
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 146 bits (369), Expect = 1e-34
Identities = 103/316 (32%), Positives = 171/316 (53%), Gaps = 34/316 (10%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLK-NLRHQN 66
G + L +V+G G YG VY+ T + AIK + ++ E +E LEI++LK + H+N
Sbjct: 19 GIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEE-DEIKLEINMLKKHSHHRN 77
Query: 67 IVEYRG-FIQKA-------HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLY 115
+ Y G FI+K +L++++E+C GS+ D++K+ G L+++ + Y+ + L
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILR 137
Query: 116 GLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEV 172
GL +LH+ VIHRDIK N+LLT+ VKL DFGVS ++++ T+ G+P WMAPEV
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 173 MTGQGA-----STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAE 227
+ + + SD+WSLG T +E+ G+PP ++ A + I PP L
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRN---PPPKLKRN 254
Query: 228 CK------DFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKS-KINLAEYIEKD---GKW 277
K F+ K+ +R LL H ++K+ ++ + ++ E+I+++ K
Sbjct: 255 KKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNRRVKKD 314
Query: 278 DVDFVLDSNTDMTPSP 293
D D+ + D PSP
Sbjct: 315 DADYEYSGSEDDEPSP 330
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 146 bits (369), Expect = 1e-34
Identities = 103/316 (32%), Positives = 171/316 (53%), Gaps = 34/316 (10%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLK-NLRHQN 66
G + L +V+G G YG VY+ T + AIK + ++ E +E LEI++LK + H+N
Sbjct: 19 GIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEE-DEIKLEINMLKKHSHHRN 77
Query: 67 IVEYRG-FIQKA-------HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLY 115
+ Y G FI+K +L++++E+C GS+ D++K+ G L+++ + Y+ + L
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILR 137
Query: 116 GLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEV 172
GL +LH+ VIHRDIK N+LLT+ VKL DFGVS ++++ T+ G+P WMAPEV
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 173 MTGQGA-----STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAE 227
+ + + SD+WSLG T +E+ G+PP ++ A + I PP L
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRN---PPPKLKRN 254
Query: 228 CK------DFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKS-KINLAEYIEKD---GKW 277
K F+ K+ +R LL H ++K+ ++ + ++ E+I+++ K
Sbjct: 255 KKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNRRVKKD 314
Query: 278 DVDFVLDSNTDMTPSP 293
D D+ + D PSP
Sbjct: 315 DADYEYSGSEDDEPSP 330
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 146 bits (369), Expect = 1e-34
Identities = 103/316 (32%), Positives = 171/316 (53%), Gaps = 34/316 (10%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLK-NLRHQN 66
G + L +V+G G YG VY+ T + AIK + ++ E +E LEI++LK + H+N
Sbjct: 19 GIFELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDEE-DEIKLEINMLKKHSHHRN 77
Query: 67 IVEYRG-FIQKA-------HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLY 115
+ Y G FI+K +L++++E+C GS+ D++K+ G L+++ + Y+ + L
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILR 137
Query: 116 GLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEV 172
GL +LH+ VIHRDIK N+LLT+ VKL DFGVS ++++ T+ G+P WMAPEV
Sbjct: 138 GLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEV 197
Query: 173 MTGQGA-----STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAE 227
+ + + SD+WSLG T +E+ G+PP ++ A + I PP L
Sbjct: 198 IACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFLIPRN---PPPKLKRN 254
Query: 228 CK------DFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKS-KINLAEYIEKD---GKW 277
K F+ K+ +R LL H ++K+ ++ + ++ E+I+++ K
Sbjct: 255 KKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTIRHSIKEHIDRNRRVKKD 314
Query: 278 DVDFVLDSNTDMTPSP 293
D D+ + D PSP
Sbjct: 315 DADYEYSGSEDDEPSP 330
>Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 607
Score = 146 bits (368), Expect = 1e-34
Identities = 84/260 (32%), Positives = 138/260 (52%), Gaps = 7/260 (2%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEH---MLEIDLLKNLRHQ 65
TY +++G+G + Y A T A+K I ++ ++ + EI+L ++L+H+
Sbjct: 22 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 81
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQG 124
+IV + + A +YI LE C+R SL I K LLE + Y+ Q L GL+YLH++G
Sbjct: 82 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG 141
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQGASTV 181
++HRD+K N +TE +K+ DFG++ R+ + T G+PN++APEV+ QG
Sbjct: 142 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 201
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
+D+WSLG + LL G+PPF + I Y P +LS + L+ + +
Sbjct: 202 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 261
Query: 242 KRATAQELLAHIWLKKIQKP 261
R + ++L H + K P
Sbjct: 262 DRPSIDQILRHDFFTKGYTP 281
>CE27177 [T] KOG4279 Serine/threonine protein kinase
Length = 1378
Score = 146 bits (368), Expect = 1e-34
Identities = 94/252 (37%), Positives = 142/252 (56%), Gaps = 16/252 (6%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRG-- 72
V+G+G YG VY A T + +K+IE + + E+ M EI L L H NIV+Y G
Sbjct: 669 VLGKGTYGTVYAARDMDTQRQIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGCD 728
Query: 73 FIQK---AHELYIILEYCARGSLRDIL--KHGPLLEDDTVNYVTQTLYGLQYLHEQGVIH 127
+ K I +E+ GSL +L K GP+ E+ Y Q L GL+YLHE ++H
Sbjct: 729 LVGKDGSNDHFLIFMEHVPGGSLSSLLRSKWGPMNENAMNYYGKQILEGLKYLHELKIVH 788
Query: 128 RDIKAANLLL-TEEGIVKLADFGVSTR---INRMAMTYAGSPNWMAPEVMT-GQ-GASTV 181
RDIK N+L+ T G+ K++DFG R +N + T+ G+ +MAPEV+ GQ G
Sbjct: 789 RDIKGDNVLVNTYSGVCKISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAP 848
Query: 182 SDIWSLGATVVELLTGNPPFHNLVN-ESACYAIVNEEYIPPL--TLSAECKDFLSRCFQK 238
+DIWS G T+VE+ TG PPF + N ++A + + + PP+ ++ +C++F+ CF
Sbjct: 849 ADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLP 908
Query: 239 NMFKRATAQELL 250
R +A++LL
Sbjct: 909 EACDRPSAKDLL 920
>ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 488
Score = 145 bits (367), Expect = 2e-34
Identities = 106/293 (36%), Positives = 156/293 (53%), Gaps = 16/293 (5%)
Query: 7 HGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML---EIDLLKNLR 63
H Y LK+++GRGAY Y A + + + A+K + +D H EI + L
Sbjct: 37 HTKYMLKKLLGRGAYAQCYLA-EIESGEQYAMKVVRLKDIKSRKVHEKLESEIAIHSKLD 95
Query: 64 HQNIVE-YRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLH 121
+ N+V+ YR F + + ++++LE C RG+L +LK +G L E +V QT+ GL YLH
Sbjct: 96 NPNVVKMYRSF-RSSEYVFMVLELCERGALDALLKRNGKLKERHVARFVKQTVEGLIYLH 154
Query: 122 EQ-GVIHRDIKAANLLLTEEGIVKLADFGVSTRIN--RMAMTYAGSPNWMAPEVMTGQ-- 176
V+HRD+K NL L + VK+ DFG+S I +T G+PN++APEV+ G+
Sbjct: 155 NSVSVVHRDLKLGNLFLDSKFNVKIGDFGLSAVIKDGEKKVTMCGTPNYIAPEVLFGKAS 214
Query: 177 GASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPP--LTLSAECKDFLSR 234
G S +DIWSLG + LL G PPF E I YI P LS+E D +++
Sbjct: 215 GHSFEADIWSLGVIIYTLLVGVPPFQKKNVEDIYKMIKLNNYIFPENCDLSSEAIDLITQ 274
Query: 235 CFQKNMFKRATAQELLAHIWLKKIQKPKSKI--NLAEYIEKDGKWDVDFVLDS 285
N +R T + +L+H +L K + KI NL ++G D D+VL S
Sbjct: 275 ILNTNPLERPTLEHILSHKFLSKKEHFLMKIYRNLMTNRTEEGVVDTDYVLFS 327
>At4g08480 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 773
Score = 145 bits (365), Expect = 3e-34
Identities = 92/256 (35%), Positives = 144/256 (55%), Gaps = 15/256 (5%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNLRHQNIV 68
Q++ +G++G VY A+ + A+K++ D+ + + EI LL L HQNI+
Sbjct: 505 QLLRQGSFGSVYEAISEDGDF-FAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEHQNIL 563
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
YRG + LYI LE +GSL ++ + + + Y Q L GL+YLH +G IHR
Sbjct: 564 RYRGTDKDGSNLYIFLELVTQGSLLELYRRYQIRDSLISLYTKQILDGLKYLHHKGFIHR 623
Query: 129 DIKAANLLLTEEGIVKLADFGVS--TRINRMAMTYAGSPNWMAPEVMT---GQGASTVSD 183
DIK A +L+ G VKLADFG++ +++N + + + WMAPEV+ G + +D
Sbjct: 624 DIKCATILVDANGTVKLADFGLAKVSKLNDI-KSRKETLFWMAPEVINRKDNDGYRSPAD 682
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKNMF 241
IWSLG TV+E+ TG P+ +L A + I +P P TLS + + F+ +C + N
Sbjct: 683 IWSLGCTVLEMCTGQIPYSDLEPVEALFRI-RRGTLPEVPDTLSLDARHFILKCLKLNPE 741
Query: 242 KRATAQELLAHIWLKK 257
+R TA ELL H ++++
Sbjct: 742 ERPTATELLNHPFVRR 757
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 145 bits (365), Expect = 3e-34
Identities = 100/289 (34%), Positives = 154/289 (52%), Gaps = 26/289 (8%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNL-RHQN 66
G + L +V+G G YG VY+ T + AIK ++ ++ E E LEI++LK H+N
Sbjct: 30 GIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEE-EEIKLEINVLKKYSNHRN 88
Query: 67 IVEYRG-FIQKA-----HELYIILEYCARGSLRDILKH--GPLLEDDTVNYVT-QTLYGL 117
I Y G FI+K+ +L++++EYC GS+ D++K G L+++ + Y+ + L GL
Sbjct: 89 IATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGL 148
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMT 174
YLH VIHRDIK N+LLT+ VKL DFGVS +++R T+ G+P WMAPEV+
Sbjct: 149 SYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIA 208
Query: 175 -----GQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECK 229
SD+WSLG T +E+ PP +L A + I PP S +
Sbjct: 209 CDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRNS--PPRLKSKKWS 266
Query: 230 ----DFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKS-KINLAEYIEK 273
F+ K+ +R + LL H ++K + +I L ++I++
Sbjct: 267 KKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDR 315
>YLR362w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 717
Score = 144 bits (363), Expect = 5e-34
Identities = 95/292 (32%), Positives = 141/292 (47%), Gaps = 52/292 (17%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES--------------ELNEH--------- 52
IG G++G VY + T + A+KQ+E ++ + E NE
Sbjct: 421 IGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIED 480
Query: 53 ---------------------MLEIDLLKNLRHQNIVEYRGFIQKAHELYIILEYCARGS 91
E++LLK L H+NIV Y G Q+ L I LEY GS
Sbjct: 481 VGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGS 540
Query: 92 LRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGV 150
+ +L +GP E N+ Q L G+ YLH++ +IHRDIK AN+L+ +G VK+ DFG+
Sbjct: 541 VSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGI 600
Query: 151 STRINRM------AMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVVELLTGNPPFHNL 204
S +++ + + GS WM+PEV+ + +DIWS G V+E+ TG PF +
Sbjct: 601 SKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDF 660
Query: 205 VNESACYAI-VNEEYIPPLTLSAECKDFLSRCFQKNMFKRATAQELLAHIWL 255
A + I N P ++E K+FL + F+ + R +A ELL H WL
Sbjct: 661 SQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQYRPSALELLQHPWL 712
>SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 589
Score = 144 bits (363), Expect = 5e-34
Identities = 88/260 (33%), Positives = 133/260 (50%), Gaps = 12/260 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNK-----PCAIKQIEFEDESELNEHMLEIDLLKNLRH 64
+ +K +G+GA G VY A G + AIK I+ + ++ + EI +++ H
Sbjct: 309 FNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRESIH 368
Query: 65 QNIVEYR-GFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
NIV Y F+ + L++++EY GSL DI++ L E +T G+Q+LH +
Sbjct: 369 PNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKLTEAQIARICLETCKGIQHLHAR 428
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMTGQGAST 180
+IHRDIK+ N+LL G +K+ DFG R++ +T G+P WMAPEV+ T
Sbjct: 429 NIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGT 488
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQ 237
DIWSLG ++E++ PP+ A Y I P +S K FL+ C
Sbjct: 489 KVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLT 548
Query: 238 KNMFKRATAQELLAHIWLKK 257
+ RATA ELL H +L +
Sbjct: 549 IDTIFRATAAELLTHSFLNQ 568
>CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 572
Score = 143 bits (361), Expect = 9e-34
Identities = 84/247 (34%), Positives = 133/247 (53%), Gaps = 6/247 (2%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
IG GA G VY A++ T AIKQ+ +D+ + + EI +++ +H NIV Y
Sbjct: 301 IGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYL 360
Query: 76 KAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANL 135
EL++++EY A GSL D++ + + + L L++LH + VIHRDIK+ N+
Sbjct: 361 VCDELWVVMEYLAGGSLTDVVTECQMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNI 420
Query: 136 LLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
LL +G VKL DFG +++ R T G+P WMAPEV+T + D+WSLG +
Sbjct: 421 LLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAI 480
Query: 193 ELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQEL 249
E++ G PP+ N A Y I ++ +++ KDF+ + + R +A +L
Sbjct: 481 EMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQL 540
Query: 250 LAHIWLK 256
L H +L+
Sbjct: 541 LTHPFLR 547
>YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 655
Score = 143 bits (360), Expect = 1e-33
Identities = 93/293 (31%), Positives = 146/293 (49%), Gaps = 35/293 (11%)
Query: 10 YALKQVIGRGAYGVVYRAVK-----------------RGTNKPCAIKQIEFEDESELNEH 52
+ L + G+GA G VY + + R + AIKQI ++ +
Sbjct: 360 FQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLI 419
Query: 53 MLEIDLLKNLRHQNIVEY-RGFIQKAHELYIILEYCARGSLRDILK----------HGPL 101
M E+ ++ + R +NIV + +I EL++I+EY G L DIL PL
Sbjct: 420 MNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPL 479
Query: 102 LEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINR---MA 158
E+ V +T GL++LH + +IHRDIK+ N+LL +G+VK+ DFG +
Sbjct: 480 NENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRSKR 539
Query: 159 MTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNE-- 216
T G+P WMAPE++ +G D+WSLG ++E++ G PP+ N A Y I N
Sbjct: 540 ATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALYLIANNGS 599
Query: 217 -EYIPPLTLSAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKS-KINL 267
+ P ++S + K FL C Q N+ RA+ ++LL +L P+ K++L
Sbjct: 600 PKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFLSMACSPEQLKVSL 652
>HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 970
Score = 143 bits (360), Expect = 1e-33
Identities = 79/263 (30%), Positives = 140/263 (53%), Gaps = 8/263 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE---DESELNEHMLEIDLLKNLRHQN 66
+ + ++G+G++ VYRA T AIK I+ + + E+ + L+H +
Sbjct: 12 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVKNEVKIHCQLKHPS 71
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHG--PLLEDDTVNYVTQTLYGLQYLHEQG 124
I+E + + ++ +Y++LE C G + LK+ P E++ +++ Q + G+ YLH G
Sbjct: 72 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG 131
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTV 181
++HRD+ +NLLLT +K+ADFG++T++ + T G+PN+++PE+ T
Sbjct: 132 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE 191
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
SD+WSLG LL G PPF ++ +V +Y P LS E KD + + ++N
Sbjct: 192 SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSIEAKDLIHQLLRRNPA 251
Query: 242 KRATAQELLAHIWLKKIQKPKSK 264
R + +L H ++ + KSK
Sbjct: 252 DRLSLSSVLDHPFMSRNSSTKSK 274
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 142 bits (359), Expect = 2e-33
Identities = 82/256 (32%), Positives = 139/256 (54%), Gaps = 6/256 (2%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHML-EIDLLKNLRH 64
G + + + +G+G +G VY A ++ T A+K + + +S++ + + EI++ NLRH
Sbjct: 116 GMFEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRH 175
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGLQYLHEQ 123
+NI+ G +Y+ILE+ RG L L+ ++ + Y+ Q L YLH++
Sbjct: 176 KNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKK 235
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRI-NRMAMTYAGSPNWMAPEVMTGQGASTVS 182
VIHRDIK N+LL +G +KL+DFG S + T G+ +++ PE++ G+ +
Sbjct: 236 HVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKV 295
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACY-AIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
D+WSLG E L G PPF ++ SA Y I + P + + +D +SR Q N
Sbjct: 296 DLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVDLKIPSFVPPDARDLISRLLQHNPE 355
Query: 242 KRATAQELLAHIWLKK 257
KR + ++++ H W+ K
Sbjct: 356 KRMSLEQVMRHPWIVK 371
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 142 bits (358), Expect = 2e-33
Identities = 79/250 (31%), Positives = 131/250 (51%), Gaps = 7/250 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML---EIDLLKNLRHQN 66
Y +V+G+G + Y NK A K I ++ ++ EI+L + L H++
Sbjct: 82 YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH 141
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNY-VTQTLYGLQYLHEQGV 125
+V++ + + +YI+LEYC+R S+ ILK +L + V Y + Q + GL+YLHEQ +
Sbjct: 142 VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI 201
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRINRMA---MTYAGSPNWMAPEVMTGQGASTVS 182
+HRD+K N + E +K+ DFG++ R+ + T G+PN+++PEV+ QG S
Sbjct: 202 LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES 261
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFK 242
DIW+LG + +L G PPF + I Y P +L A K ++ KN
Sbjct: 262 DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED 321
Query: 243 RATAQELLAH 252
R + +++ H
Sbjct: 322 RPSLDDIIRH 331
>Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 968
Score = 142 bits (357), Expect = 3e-33
Identities = 89/261 (34%), Positives = 136/261 (52%), Gaps = 13/261 (4%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G GA+G VY+A + T A K IE + E EL ++++EI++L H IV+ G
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYY 101
Query: 76 KAHELYIILEYCARGSLRDILKH--GPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAA 133
+L+I++E+C G++ I+ L E Q L L +LH + +IHRD+KA
Sbjct: 102 HDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAG 161
Query: 134 NLLLTEEGIVKLADFGVSTRINRMAM---TYAGSPNWMAPEVMTGQGASTV-----SDIW 185
N+L+T EG ++LADFGVS + + ++ G+P WMAPEV+ + +DIW
Sbjct: 162 NVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIW 221
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNEE---YIPPLTLSAECKDFLSRCFQKNMFK 242
SLG T++E+ PP H L I + + P S E +DFL KN
Sbjct: 222 SLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPET 281
Query: 243 RATAQELLAHIWLKKIQKPKS 263
R +A +LL H ++ I K+
Sbjct: 282 RPSAAQLLEHPFVSSITSNKA 302
>Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 970
Score = 142 bits (357), Expect = 3e-33
Identities = 78/263 (29%), Positives = 140/263 (52%), Gaps = 8/263 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE---DESELNEHMLEIDLLKNLRHQN 66
+ + ++G+G++ VYRA + AIK I+ + + E+ + L+H +
Sbjct: 12 FKVGNLLGKGSFAGVYRAESIHSGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 71
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHG--PLLEDDTVNYVTQTLYGLQYLHEQG 124
I+E + + ++ +Y++LE C G + LK+ P E++ +++ Q + G+ YLH G
Sbjct: 72 ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHG 131
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTV 181
++HRD+ +NLLLT +K+ADFG++T++ + T G+PN+++PE+ T
Sbjct: 132 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLE 191
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
SD+WSLG LL G PPF ++ +V +Y P LS E KD + + ++N
Sbjct: 192 SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSIEAKDLIHQLLRRNPA 251
Query: 242 KRATAQELLAHIWLKKIQKPKSK 264
R + +L H ++ + KSK
Sbjct: 252 DRLSLSSVLDHPFMSRNSSTKSK 274
>CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1228
Score = 142 bits (357), Expect = 3e-33
Identities = 91/268 (33%), Positives = 144/268 (52%), Gaps = 21/268 (7%)
Query: 16 IGRGAYGVVYRAVKRGTNKP-CAIKQIEFEDESELNEHMLEIDLLKNLR-HQNIVEYRGF 73
+G GA+G V +AV R K A K IE ++ EL + ++EI++L + H ++
Sbjct: 40 LGDGAFGKVEKAVSRTDPKLFAASKSIEIQEGEELEDFLVEIEILSECKGHPVMLGLYST 99
Query: 74 IQKAHELYIILEYCARGSLRDILKH-GPLLEDDTVNYVTQTLY-GLQYLHEQGVIHRDIK 131
++L ++LE+C G++ +I+ G +L++D + Y+ + L++LH Q VIHRD+K
Sbjct: 100 YFFENKLTMLLEFCGGGAVDNIIVELGHVLKEDQIRYIGYYVCDALKWLHSQNVIHRDLK 159
Query: 132 AANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMT-----GQGASTVSD 183
A N+LLT++G V+LADFGVS ++ T+ G+P WMAPEVM Q +SD
Sbjct: 160 AGNILLTQDGQVRLADFGVSAKLKSEREKRDTFIGTPYWMAPEVMACETFKDQPYDCISD 219
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL------SAECKDFLSRCFQ 237
IWS G T++E+ G PP ++ S I+ + P TL + D L+RC
Sbjct: 220 IWSFGITLIEMAQGEPPHSDV---SVMRVIIKVQKSEPPTLLQPSHWTRSFSDILTRCLV 276
Query: 238 KNMFKRATAQELLAHIWLKKIQKPKSKI 265
K+ R A E+ H W + + I
Sbjct: 277 KDPRNRPPAAEIFKHQWFQNAPSKRKMI 304
>At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 710
Score = 141 bits (356), Expect = 3e-33
Identities = 91/283 (32%), Positives = 144/283 (50%), Gaps = 27/283 (9%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
Y L + IG GA VVYRA+ TN+ AIK ++ + S L++ E + + H N++
Sbjct: 33 YKLMEEIGHGASAVVYRAIYLPTNEVVAIKCLDLDRCNSNLDDIRRESQTMSLIDHPNVI 92
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILK--HGPLLEDDTVNYVT-QTLYGLQYLHEQGV 125
+ H L++++ + A+GS ++K + E+ + V +TL L YLH QG
Sbjct: 93 KSFCSFSVDHSLWVVMPFMAQGSCLHLMKTAYSDGFEESAICCVLKETLKALDYLHRQGH 152
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRI------NRMAMTYAGSPNWMAPEVM-TGQGA 178
IHRD+KA N+LL + G +KL DFGVS + R T+ G+P WMAPEV+ G G
Sbjct: 153 IHRDVKAGNILLDDNGEIKLGDFGVSACLFDNGDRQRARNTFVGTPCWMAPEVLQPGNGY 212
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPP--------------LTL 224
++ +DIWS G T +EL G+ PF ++ + PP +
Sbjct: 213 NSKADIWSFGITALELAHGHAPFSKYPPMKV--LLMTIQNAPPGLDYDRDKKFSKRTFSC 270
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINL 267
+ K+ ++ C K+ KR TA++LL H K + P+ + +
Sbjct: 271 AQSFKEMVAMCLVKDQTKRPTAEKLLKHSCFKHTKPPEQTVKI 313
>CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 545
Score = 140 bits (352), Expect = 1e-32
Identities = 97/282 (34%), Positives = 135/282 (47%), Gaps = 35/282 (12%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
Y L + IG GA V+ A N+ AIK I E ++ ++E EI + H N+V
Sbjct: 57 YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVV 116
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKH------------GPLLEDDTVNYVTQTLYG 116
Y EL++++ GS+ DILK G L E + + L G
Sbjct: 117 SYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKG 176
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRI---------NRMAMTYAGSPNW 167
L+Y H G IHRDIKA N+LL ++G +++ADFGVS + ++ T+ G+P W
Sbjct: 177 LEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCW 236
Query: 168 MAPEVMTG-QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSA 226
MAPEVM QG +DIWSLG +EL TG P+H + + P L +A
Sbjct: 237 MAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQND-PPTLETNA 295
Query: 227 ECKD-----------FLSRCFQKNMFKRATAQELLAHIWLKK 257
E KD + C QK+ KR TA ELL + + KK
Sbjct: 296 ERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFKK 337
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 139 bits (351), Expect = 1e-32
Identities = 87/251 (34%), Positives = 132/251 (51%), Gaps = 15/251 (5%)
Query: 37 AIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEY-RGFIQKAHELYIILEYCARGSLRDI 95
AIKQ+ + + EI ++K+ RH+NIV + +++ +L++++E+ GSL DI
Sbjct: 592 AIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDI 651
Query: 96 LK--------HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLAD 147
++ H PL E V +T GL++LH++ +IHRDIK+ N+LL VK+ D
Sbjct: 652 IENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITD 711
Query: 148 FGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVVELLTGNPPFHNL 204
FG R+ T G+P WMAPEV+ + D+WSLG +E+L G PP+ N
Sbjct: 712 FGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNE 771
Query: 205 VNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKP 261
A Y I + P +LS E K FLS C ++ RA+ +ELL H + P
Sbjct: 772 DPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNMACDP 831
Query: 262 KSKINLAEYIE 272
K +L E+ E
Sbjct: 832 KDLTSLLEWKE 842
>At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 693
Score = 139 bits (350), Expect = 2e-32
Identities = 87/276 (31%), Positives = 144/276 (51%), Gaps = 23/276 (8%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
Y L + +G GA VV+RA+ TN+ AIK ++ + S L++ E + + H N++
Sbjct: 27 YKLMEEVGYGASAVVHRAIYLPTNEVVAIKSLDLDRCNSNLDDIRREAQTMTLIDHPNVI 86
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHG---PLLEDDTVNYVTQTLYGLQYLHEQGV 125
+ H L++++ + A+GS ++K E + + +TL L YLH QG
Sbjct: 87 KSFCSFAVDHHLWVVMPFMAQGSCLHLMKAAYPDGFEEAAICSMLKETLKALDYLHRQGH 146
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRI------NRMAMTYAGSPNWMAPEVM-TGQGA 178
IHRD+KA N+LL + G +KL DFGVS + R T+ G+P WMAPEV+ G G
Sbjct: 147 IHRDVKAGNILLDDTGEIKLGDFGVSACLFDNGDRQRARNTFVGTPCWMAPEVLQPGSGY 206
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIV-----------NEEYIPPLTLSAE 227
++ +DIWS G T +EL G+ PF + ++++ ++ A+
Sbjct: 207 NSKADIWSFGITALELAHGHAPFSKYPPMKVLLMTIQNAPPGLDYDRDKKFSKKMSSCAQ 266
Query: 228 C-KDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPK 262
K+ ++ C K+ KR TA++LL H + K ++ P+
Sbjct: 267 SFKELVALCLVKDQTKRPTAEKLLKHSFFKNVKPPE 302
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 139 bits (349), Expect = 2e-32
Identities = 88/277 (31%), Positives = 151/277 (53%), Gaps = 27/277 (9%)
Query: 1 MDNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES-ELNEHML-EIDL 58
M+++ G YAL IG G++ VV+ A R + A+K+I+ + S ++ +++L EI +
Sbjct: 1 MESARLVGDYALGPRIGSGSFAVVWLAKHRSSGLEVAVKEIDKKLLSPKVRDNLLKEISI 60
Query: 59 LKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGL 117
L + H NI+ + I+ ++++LEYC+ G L + +HG + E +++ Q GL
Sbjct: 61 LSTIDHPNIIRFYEAIETGDRIFLVLEYCSGGDLAGYINRHGKVPEAVAKHFMRQLALGL 120
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGI---VKLADFGVSTRIN--RMAMTYAGSPNWMAPEV 172
Q L E+ IHRD+K NLLL+ + + +K+ DFG + + MA T+ GSP +MAPE+
Sbjct: 121 QVLQEKHFIHRDLKPQNLLLSSKEVTPLLKIGDFGFARSLTPESMAETFCGSPLYMAPEI 180
Query: 173 MTGQGASTVSDIWSLGATVVELLTGNPP---------FHNLVNESACYAIVNEEYIPPLT 223
+ Q +D+WS GA + +L+TG PP FHN+V ++ E P T
Sbjct: 181 IRNQKYDAKADLWSAGAILFQLVTGKPPFDGNNHIQLFHNIVRDT-------ELKFPEDT 233
Query: 224 ---LSAECKDFLSRCFQKNMFKRATAQELLAHIWLKK 257
+ +C D ++N +R T +E H++L++
Sbjct: 234 RNEIHPDCVDLCRSLLRRNPIERLTFREFFNHMFLRE 270
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 139 bits (349), Expect = 2e-32
Identities = 92/275 (33%), Positives = 150/275 (54%), Gaps = 29/275 (10%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHM-LEIDLLKNL-RHQN 66
T+ + + IG+G YG VY+ + A+K ++ S+++E + E ++L+ L H N
Sbjct: 26 TWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILD--PVSDMDEEIEAEYNILQFLPNHPN 83
Query: 67 IVEYRGFIQKAH-----ELYIILEYCARGSLRDILKH----GPLLEDDTVNYVTQ-TLYG 116
+V++ G KA +L+++LE C GS+ +++K G L++ ++Y+ L G
Sbjct: 84 VVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLG 143
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM---TYAGSPNWMAPEVM 173
LQ+LH +IHRD+K N+LLT EG VKL DFGVS ++ + T G+P WMAPEV+
Sbjct: 144 LQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVI 203
Query: 174 TGQGASTVS-----DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAE- 227
+ S D+WSLG T +EL G+PP ++ + I PP L E
Sbjct: 204 ACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNP--PPTLLHPEK 261
Query: 228 -CKD---FLSRCFQKNMFKRATAQELLAHIWLKKI 258
C++ F+S+C K+ +R + LL H ++K +
Sbjct: 262 WCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGV 296
>CE01405 [T] KOG0577 Serine/threonine protein kinase
Length = 982
Score = 137 bits (344), Expect = 8e-32
Identities = 91/277 (32%), Positives = 147/277 (52%), Gaps = 27/277 (9%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESEL---NEHMLEIDLLKNLRHQNIVEYRG 72
IG G++G VY A + + AIK++ F + + N+ + E+ L + H +IV+Y+
Sbjct: 36 IGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVDYKA 95
Query: 73 FIQKAHELYIILEYC--ARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDI 130
K ++++EYC + + D+L+ G + E + +QTL L+YLH IHRDI
Sbjct: 96 CFLKDTTCWLVMEYCIGSAADIVDVLRKG-MREVEIAAICSQTLDALRYLHSLKRIHRDI 154
Query: 131 KAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTGQGA---STVSDIWSL 187
KA N+LL++ IVKLADFG ++ ++ A T+ G+P +MAPEV+ + +DIWSL
Sbjct: 155 KAGNILLSDHAIVKLADFGSASLVD-PAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSL 213
Query: 188 GATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL-----------SAECKDFLSRCF 236
G T +EL PP ++ SA Y I + P TL S E F+ +C
Sbjct: 214 GITCIELAERRPPLFSMNAMSALYHIAQND---PPTLSPIDTSEQPEWSLEFVQFIDKCL 270
Query: 237 QKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEK 273
+K +R +A+E H + IQ+ + + E I++
Sbjct: 271 RKPAEERMSAEECFRHPF---IQRSRPSDTIQELIQR 304
>At2g45490 [D] KOG0580 Serine/threonine protein kinase
Length = 288
Score = 137 bits (344), Expect = 8e-32
Identities = 86/260 (33%), Positives = 138/260 (53%), Gaps = 8/260 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNE--HML--EIDLLKNLRHQ 65
+ + + +G+G +G VY A + + A+K I F+++ E + H L E+++ +LRH
Sbjct: 22 FEIGRPLGKGKFGRVYLAREAKSKYIVALKVI-FKEQIEKYKIHHQLRREMEIQTSLRHP 80
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NI+ G+ +++ILEY G L +LK +G L E Y+ L Y H +
Sbjct: 81 NILRLFGWFHDNERIFLILEYAHGGELYGVLKQNGHLTEQQAATYIASLSQALAYCHGKC 140
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTGQGASTVSDI 184
VIHRDIK NLLL EG +K+ADFG S + + T G+ +++APE++ + D
Sbjct: 141 VIHRDIKPENLLLDHEGRLKIADFGWSVQSSNKRKTMCGTLDYLAPEMVENRDHDYAVDN 200
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLT--LSAECKDFLSRCFQKNMFK 242
W+LG E L GNPPF + I+ + PLT +S E K+ +S+ K+ K
Sbjct: 201 WTLGILCYEFLYGNPPFEAESQKDTFKRILKIDLSFPLTPNVSEEAKNLISQLLVKDPSK 260
Query: 243 RATAQELLAHIWLKKIQKPK 262
R + ++++ H W+ K PK
Sbjct: 261 RLSIEKIMQHPWIVKNADPK 280
>7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1612
Score = 137 bits (344), Expect = 8e-32
Identities = 88/256 (34%), Positives = 134/256 (51%), Gaps = 15/256 (5%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLLKNLRHQNIVEYRGF 73
IG+G +G VY AV T + A+K+I + + L E+ +L+ ++H+N+V Y G
Sbjct: 1329 IGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYYGI 1388
Query: 74 IQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKA 132
EL I +E C+ G+L +++ G L E T + Q L G+ LH+ G++HRDIK
Sbjct: 1389 EVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKT 1448
Query: 133 ANLLLTE-EGIVKLADFGVSTRINRMAMT------YAGSPNWMAPEVMT---GQGASTVS 182
AN+ L + +KL DFG + +I Y G+ +MAPEV T G +
Sbjct: 1449 ANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAA 1508
Query: 183 DIWSLGATVVELLTGNPPFHNL-VNESACYAI-VNEEYIPPLTLSAECKDFLSRCFQKNM 240
DIWS+G VVE+ +G P+ N + + + E+ P +LS E DF+ C Q +
Sbjct: 1509 DIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDP 1568
Query: 241 FKRATAQELLAHIWLK 256
+R TA ELL H + K
Sbjct: 1569 KRRLTAVELLEHNFCK 1584
>Hs21361643 [T] KOG4717 Serine/threonine protein kinase
Length = 765
Score = 136 bits (343), Expect = 1e-31
Identities = 94/278 (33%), Positives = 148/278 (52%), Gaps = 16/278 (5%)
Query: 2 DNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNE----HML-EI 56
D IA G Y L + +GRG + VV A T + A+K I D+++L+ H+ E+
Sbjct: 9 DGKIA-GLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVI---DKTKLDTLATGHLFQEV 64
Query: 57 DLLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVN-YVTQTL 114
+K ++H NIV I +LY+ILE G + D I+KH L +D Y Q +
Sbjct: 65 RCMKLVQHPNIVRLYEVIDTQTKLYLILELGDEGDMFDYIMKHEEGLNEDLPKKYFAQIV 124
Query: 115 YGLQYLHEQGVIHRDIKAANLLLTE-EGIVKLADFGVSTRIN--RMAMTYAGSPNWMAPE 171
+ + Y H+ V+HRD+K N++ E +G+VKL DFG S + + T GS + APE
Sbjct: 125 HAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPE 184
Query: 172 VMTGQGASTVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKD 230
++ G + DIWSLG + L+ G PPF + I++ +Y P +S ECKD
Sbjct: 185 ILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKD 244
Query: 231 FLSRCFQKNMFKRATAQELLAHIWLKKIQ-KPKSKINL 267
++R Q++ +RA+ +E+ H WL+ + P +K N+
Sbjct: 245 LITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNI 282
>7302570 [R] KOG0586 Serine/threonine protein kinase
Length = 702
Score = 136 bits (343), Expect = 1e-31
Identities = 86/265 (32%), Positives = 135/265 (50%), Gaps = 6/265 (2%)
Query: 1 MDNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDL 58
+D + G Y L++ IG+G + VV A T AIK I+ +E LN+ EI +
Sbjct: 32 VDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAI 91
Query: 59 LKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGL 117
LK+LRH +I ++ +Y++ EY G + D ++ +G + E + TQ + +
Sbjct: 92 LKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAV 151
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVMTG 175
Y H +GV+HRD+KA N+LL ++ +KLADFG S A T+ GSP + APEV G
Sbjct: 152 HYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQG 211
Query: 176 -QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSR 234
+ SDIWSLG + L+ G PF +V ++ P +S EC+ +
Sbjct: 212 LEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRN 271
Query: 235 CFQKNMFKRATAQELLAHIWLKKIQ 259
+R T ++++ H WL + Q
Sbjct: 272 MLVVEPDRRYTIKQIIKHRWLSEWQ 296
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 135 bits (341), Expect = 2e-31
Identities = 90/284 (31%), Positives = 149/284 (51%), Gaps = 30/284 (10%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEF--EDESELNEHMLEIDLLKNLRHQNIVEYRG 72
++G GA G V + + K A+K I D + E+ K+ + IV+Y G
Sbjct: 219 ILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYG 278
Query: 73 FI--QKAHELYIILEYCARGSL----RDILKHGPLLEDDTVNYVTQT-LYGLQYLHEQGV 125
+++ +YI +EY SL +++LK G + + + + ++ L GL YLHE+ V
Sbjct: 279 MFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKV 338
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVS-TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDI 184
IHRDIK N+LL E+G +KL DFGVS +N +AMT+ G+ +MAPE + GQ S D+
Sbjct: 339 IHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDV 398
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPP-LTLSAECKD------------- 230
WSLG T++E+ G PF ++ + E + LT S + KD
Sbjct: 399 WSLGLTLLEVAGGRFPFE---SDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFR 455
Query: 231 -FLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEK 273
F+ C +K+ +R + +++L H W+ + + K K+N+ +++K
Sbjct: 456 SFIDYCLKKDARERPSPRQMLKHPWI--VGQMKKKVNMERFVKK 497
>At4g26890 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 444
Score = 135 bits (341), Expect = 2e-31
Identities = 84/250 (33%), Positives = 147/250 (58%), Gaps = 15/250 (6%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEY--RG 72
+IGRG+ V A+ + + A+K + S L + E +L L ++V+Y G
Sbjct: 10 IIGRGSTATVSIAIS-SSGELFAVKSADLSSSSLLQK---EQSILSTLSSPHMVKYIGTG 65
Query: 73 FIQKAHELY--IILEYCARGSLRDILKH--GPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
++++ L I++EY + G+L D++K+ G L E + +Y Q L GL YLHE+G++H
Sbjct: 66 LTRESNGLVYNILMEYVSGGNLHDLIKNSGGKLPEPEIRSYTRQILNGLVYLHERGIVHC 125
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLG 188
D+K+ N+L+ E G++K+AD G + +++ ++G+P +MAPEV G+ +D+W+LG
Sbjct: 126 DLKSHNVLVEENGVLKIADMGCAKSVDK--SEFSGTPAFMAPEVARGEEQRFPADVWALG 183
Query: 189 ATVVELLTGNPPFHNLVN-ESACYAI--VNEEYIPPLTLSAECKDFLSRCFQKNMFKRAT 245
T++E++TG+ P+ L + +A Y I E P +S + KDFL C +++ +R T
Sbjct: 184 CTMIEMMTGSSPWPELNDVVAAMYKIGFSGESPAIPAWISDKAKDFLKNCLKEDQKQRWT 243
Query: 246 AQELLAHIWL 255
+ELL H +L
Sbjct: 244 VEELLKHPFL 253
>At4g18700 [T] KOG0583 Serine/threonine protein kinase
Length = 489
Score = 135 bits (341), Expect = 2e-31
Identities = 93/277 (33%), Positives = 143/277 (51%), Gaps = 16/277 (5%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHML-EIDLLKNLRH 64
G Y + +++G G + VY A TN+ AIK I+ E + L H+ EI +L+ +RH
Sbjct: 24 GRYEMGKLLGHGTFAKVYLARNVKTNESVAIKVIDKEKVLKGGLIAHIKREISILRRVRH 83
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV+ + ++Y ++EY G L + + G L E+ Y Q + + + H +G
Sbjct: 84 PNIVQLFEVMATKAKIYFVMEYVRGGELFNKVAKGRLKEEVARKYFQQLISAVTFCHARG 143
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTGQGAS 179
V HRD+K NLLL E G +K++DFG+S R + + T+ G+P ++APEV+ +G
Sbjct: 144 VYHRDLKPENLLLDENGNLKVSDFGLSAVSDQIRQDGLFHTFCGTPAYVAPEVLARKGYD 203
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACY-AIVNEEYIPPLTLSAECKDFLSRCFQ 237
DIWS G + L+ G PFH+ N A Y I E+ P S E LS+ +
Sbjct: 204 AAKVDIWSCGVILFVLMAGYLPFHDR-NVMAMYKKIYRGEFRCPRWFSTELTRLLSKLLE 262
Query: 238 KNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKD 274
N KR T E++ + W KK K ++ Y+E D
Sbjct: 263 TNPEKRFTFPEIMENSWFKKGFK-----HIKFYVEDD 294
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 135 bits (339), Expect = 3e-31
Identities = 83/254 (32%), Positives = 128/254 (49%), Gaps = 6/254 (2%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
IG G+ GVV A K T + A+K++ + E+ +L+ +H NIV +
Sbjct: 255 IGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHL 314
Query: 76 KAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANL 135
EL++++E+ GSL DI+ + E Q L L +LH + VIHRDIK+ ++
Sbjct: 315 VDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSI 374
Query: 136 LLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
LL +G VKL DFG +++ + G+P W A EV+ + T +DIWS G ++
Sbjct: 375 LLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLI 434
Query: 193 ELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQEL 249
E++ G PPF N A I +E + +S E + LS C K++ KR A++L
Sbjct: 435 EMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDL 494
Query: 250 LAHIWLKKIQKPKS 263
L H + K Q S
Sbjct: 495 LRHPFFAKAQHSSS 508
>CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 542
Score = 135 bits (339), Expect = 3e-31
Identities = 83/254 (32%), Positives = 128/254 (49%), Gaps = 6/254 (2%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
IG G+ GVV A K T + A+K++ + E+ +L+ +H NIV +
Sbjct: 257 IGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHL 316
Query: 76 KAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANL 135
EL++++E+ GSL DI+ + E Q L L +LH + VIHRDIK+ ++
Sbjct: 317 VDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRDIKSDSI 376
Query: 136 LLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
LL +G VKL DFG +++ + G+P W A EV+ + T +DIWS G ++
Sbjct: 377 LLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLI 436
Query: 193 ELLTGNPPFHNLVNESACYAIVNE---EYIPPLTLSAECKDFLSRCFQKNMFKRATAQEL 249
E++ G PPF N A I +E + +S E + LS C K++ KR A++L
Sbjct: 437 EMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDL 496
Query: 250 LAHIWLKKIQKPKS 263
L H + K Q S
Sbjct: 497 LRHPFFAKAQHSSS 510
>At2g32510 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 372
Score = 135 bits (339), Expect = 3e-31
Identities = 82/256 (32%), Positives = 137/256 (53%), Gaps = 17/256 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGF 73
+++GRG+ VY A +++ A+K E L E +L +L ++ YRG
Sbjct: 7 RILGRGSTATVYAAAGHNSDEILAVKSSEVHRSEFLQR---EAKILSSLSSPYVIGYRGS 63
Query: 74 IQKAHE----LY-IILEYCARGSLRDILKH--GPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
K +Y +++EY G+L D G + E V Y L GL+Y+H +G++
Sbjct: 64 ETKRESNGVVMYNLLMEYAPYGTLTDAAAKDGGRVDETRVVKYTRDILKGLEYIHSKGIV 123
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRINRM-AMTYAGSPNWMAPEVMTGQGASTVSDIW 185
H D+K +N++++E+G K+ADFG + R++ + G+P +MAPEV G+ SDIW
Sbjct: 124 HCDVKGSNVVISEKGEAKIADFGCAKRVDPVFESPVMGTPAFMAPEVARGEKQGKESDIW 183
Query: 186 SLGATVVELLTGNPPFHNLVNE----SACYAIVNEEYIP--PLTLSAECKDFLSRCFQKN 239
++G T++E++TG+PP+ + S Y + P P L+ E KDFL +C ++
Sbjct: 184 AVGCTMIEMVTGSPPWTKADSREDPVSVLYRVGYSSETPELPCLLAEEAKDFLEKCLKRE 243
Query: 240 MFKRATAQELLAHIWL 255
+R TA +LL H +L
Sbjct: 244 ANERWTATQLLNHPFL 259
>7303211 [T] KOG4717 Serine/threonine protein kinase
Length = 860
Score = 134 bits (338), Expect = 4e-31
Identities = 91/296 (30%), Positives = 152/296 (50%), Gaps = 15/296 (5%)
Query: 2 DNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML--EIDLL 59
D IA G Y L++ +G G + VV A T A+K ++ ++++ L E+ +
Sbjct: 13 DGKIA-GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCM 71
Query: 60 KNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVN-YVTQTLYGL 117
K ++H N+V I +LY++LE G L D I+KH L ++ Y Q L +
Sbjct: 72 KLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAI 131
Query: 118 QYLHEQGVIHRDIKAANLLLTEE-GIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMT 174
Y H+ V+HRD+K N++ E+ G+VKL DFG S + + T+ GS + APE++
Sbjct: 132 TYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILL 191
Query: 175 GQGASTVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLS 233
G + DIWSLG + L+ G PF + I++ +Y P +S +C+D ++
Sbjct: 192 GDSYDAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIA 251
Query: 234 RCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYI------EKDGKWDVDFVL 283
++ KRAT +E+ + WLK I +P S + +E+ E+ G+ D F++
Sbjct: 252 SMLVRDPKKRATVEEIASSAWLKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFII 307
>7290249 [R] KOG0586 Serine/threonine protein kinase
Length = 1398
Score = 134 bits (337), Expect = 5e-31
Identities = 80/254 (31%), Positives = 135/254 (52%), Gaps = 6/254 (2%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLLKNLRHQ 65
G Y +++ IG+G + VV A R T AIK I+ D++ L + E++++K L+H
Sbjct: 139 GFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHP 198
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
+I++ ++ + +YI+ EY ++G + D I K+G + E Q + ++Y H++G
Sbjct: 199 HIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIISAVEYCHKKG 258
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTG-QGASTV 181
++HRD+KA NLLL +K+ADFG S + T+ GSP + APEV G Q
Sbjct: 259 IVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGSPPYAAPEVFEGKQYTGPE 318
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
DIWSLG + L+ G PF +S +++ + P +S+EC+ + R
Sbjct: 319 IDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSECEHLIRRMLVLEPT 378
Query: 242 KRATAQELLAHIWL 255
+R T ++ H W+
Sbjct: 379 RRYTIDQIKRHRWM 392
>Hs18602554 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 227
Score = 134 bits (336), Expect = 7e-31
Identities = 77/205 (37%), Positives = 115/205 (55%), Gaps = 8/205 (3%)
Query: 59 LKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQ 118
+K L++ NIV + EL++++EY ARGSL D++ + E ++L L+
Sbjct: 1 MKELKNPNIVNFLDSYLVGDELFVVVEYLARGSLTDVVTETCMDEAQIAAVCRESLQALE 60
Query: 119 YLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTG 175
+LH VIHRDIK+ ++LL EG VKL DFG +I T +P WMAPEV+T
Sbjct: 61 FLHANQVIHRDIKSDSVLLGMEGSVKLTDFGFCAQITPEQSKRSTVVRTPYWMAPEVVTR 120
Query: 176 QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP----PLTLSAECKDF 231
+ ++WSLG E++ G PP+ N N ++ IP P TLS +DF
Sbjct: 121 KAYGPKVNVWSLGIMATEMVEGEPPYLN-ENPLRALCLIATNGIPELQNPETLSPIFRDF 179
Query: 232 LSRCFQKNMFKRATAQELLAHIWLK 256
L+RC + ++ KR +A+ELL H++LK
Sbjct: 180 LNRCLETDVEKRGSAKELLQHLFLK 204
>At4g32830 [D] KOG0580 Serine/threonine protein kinase
Length = 294
Score = 134 bits (336), Expect = 7e-31
Identities = 86/253 (33%), Positives = 129/253 (49%), Gaps = 8/253 (3%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN--EHML--EIDLLKNLRHQNIVEYR 71
+GRG +G VY A ++ +N A+K + F+ + + + EH L E+++ +LRH NI+
Sbjct: 37 LGRGKFGHVYLAREKRSNHVVALKVL-FKSQLQQSQVEHQLRREVEIQSHLRHPNILRLY 95
Query: 72 GFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDI 130
G+ +Y+ILEY ARG L +D+ K E YV L Y H + VIHRDI
Sbjct: 96 GYFYDQKRVYLILEYAARGELYKDLQKCKYFSERRAATYVASLARALIYCHGKHVIHRDI 155
Query: 131 KAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
K NLL+ +G +K+ADFG S T G+ +++ PE++ DIWSLG
Sbjct: 156 KPENLLIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMVESVEHDASVDIWSLGIL 215
Query: 191 VVELLTGNPPFHNLVNESACYAIVNEE--YIPPLTLSAECKDFLSRCFQKNMFKRATAQE 248
E L G PPF + + IV + + P +SA KD +S+ K +R +
Sbjct: 216 CYEFLYGVPPFEAMEHSDTYRRIVQVDLKFPPKPIISASAKDLISQMLVKESSQRLPLHK 275
Query: 249 LLAHIWLKKIQKP 261
LL H W+ + P
Sbjct: 276 LLEHPWIVQNADP 288
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 134 bits (336), Expect = 7e-31
Identities = 100/290 (34%), Positives = 151/290 (51%), Gaps = 19/290 (6%)
Query: 2 DNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE-DESELNEHMLEIDLLK 60
D+ ++ + +VIG+G+ GVV + T + A+K I+ DE+ E+ + +
Sbjct: 62 DDQLSLSDLDMVKVIGKGSSGVVQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQ 121
Query: 61 NLRHQNIV-EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYV-TQTLYGLQ 118
+ + N+V Y+ F + +ILEY GSL D LK + D ++ + Q L GL
Sbjct: 122 SSQCPNLVTSYQSFYDNG-AISLILEYMDGGSLADFLKSVKAIPDSYLSAIFRQVLQGLI 180
Query: 119 YLH-EQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMT 174
YLH ++ +IHRD+K +NLL+ G VK+ DFGVST + +A T+ G+ N+M+PE +
Sbjct: 181 YLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIV 240
Query: 175 GQGASTVSDIWSLGATVVELLTGNPPFHNLVNESA-------CYAIVNE--EYIPPLTLS 225
G SDIWSLG V+E TG P+ E AIV++ +P S
Sbjct: 241 GNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQPPPALPSGNFS 300
Query: 226 AECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDG 275
E F+S C QK+ R++A+EL+ H +L K S INLA Y G
Sbjct: 301 PELSSFISTCLQKDPNSRSSAKELMEHPFLNKYD--YSGINLASYFTDAG 348
>At2g26980 [T] KOG0583 Serine/threonine protein kinase
Length = 441
Score = 133 bits (335), Expect = 9e-31
Identities = 86/267 (32%), Positives = 135/267 (50%), Gaps = 16/267 (5%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML------EIDLLKN 61
G Y + + IG G + V A T +P A+K + D+ ++ +H + EI +K
Sbjct: 12 GKYEVGRTIGEGTFAKVKFARNSETGEPVALKIL---DKEKVLKHKMAEQIRREIATMKL 68
Query: 62 LRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYL 120
++H N+V+ + +++IILEY G L D I+ G + ED+ Y Q ++ + Y
Sbjct: 69 IKHPNVVQLYEVMASKTKIFIILEYVTGGELFDKIVNDGRMKEDEARRYFQQLIHAVDYC 128
Query: 121 HEQGVIHRDIKAANLLLTEEGIVKLADFGVS-----TRINRMAMTYAGSPNWMAPEVMTG 175
H +GV HRD+K NLLL G +K++DFG+S R + + T G+PN++APEV+
Sbjct: 129 HSRGVYHRDLKPENLLLDSYGNLKISDFGLSALSQQVRDDGLLHTSCGTPNYVAPEVLND 188
Query: 176 QG-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSR 234
+G +D+WS G + LL G PF + + I + E+ P LS ++R
Sbjct: 189 RGYDGATADMWSCGVVLYVLLAGYLPFDDSNLMNLYKKISSGEFNCPPWLSLGAMKLITR 248
Query: 235 CFQKNMFKRATAQELLAHIWLKKIQKP 261
N R T QE+ W KK KP
Sbjct: 249 ILDPNPMTRVTPQEVFEDEWFKKDYKP 275
>7299536 [D] KOG0580 Serine/threonine protein kinase
Length = 411
Score = 133 bits (335), Expect = 9e-31
Identities = 80/253 (31%), Positives = 135/253 (52%), Gaps = 7/253 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN-EHML--EIDLLKNLRHQN 66
+ + +++GRG +G VY A ++ + A+K + E N EH + EI++ +LRH +
Sbjct: 154 FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPH 213
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDD---TVNYVTQTLYGLQYLHEQ 123
I+ + +Y+ILEY +G+L + L+ P+ D + Y+ L YLHE+
Sbjct: 214 ILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHER 273
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRI-NRMAMTYAGSPNWMAPEVMTGQGASTVS 182
+IHRDIK NLLL +G++K+ADFG S N M MT G+ +++ PE++ G+ +
Sbjct: 274 DIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNV 333
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFK 242
D+WSLG ELL G+ PF++ + I+ +Y P +S +S+ N
Sbjct: 334 DLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQH 393
Query: 243 RATAQELLAHIWL 255
R +++ H W+
Sbjct: 394 RLPLDQVMVHPWI 406
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 132 bits (332), Expect = 2e-30
Identities = 81/251 (32%), Positives = 131/251 (51%), Gaps = 5/251 (1%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI-EFEDESELNEHML--EIDLLKNLRHQN 66
+ + + +G+G +G VY A ++ + A+K + + + E EH L E+++ +LRH N
Sbjct: 133 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPN 192
Query: 67 IVEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
I+ G+ A +Y+ILEY G++ R++ K E T Y+T+ L Y H + V
Sbjct: 193 ILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRV 252
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRI-NRMAMTYAGSPNWMAPEVMTGQGASTVSDI 184
IHRDIK NLLL G +K+ADFG S + T G+ +++ PE++ G+ D+
Sbjct: 253 IHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDL 312
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRA 244
WSLG E L G PPF + I E+ P ++ +D +SR + N +R
Sbjct: 313 WSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRP 372
Query: 245 TAQELLAHIWL 255
+E+L H W+
Sbjct: 373 MLREVLEHPWI 383
>At1g29230 [T] KOG0583 Serine/threonine protein kinase
Length = 520
Score = 132 bits (332), Expect = 2e-30
Identities = 95/322 (29%), Positives = 156/322 (47%), Gaps = 16/322 (4%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHML-EIDLL 59
N+I G Y L +++G G + VY A + AIK I+ E +S L H+ EI +L
Sbjct: 67 NNILMGKYELGKLLGHGTFAKVYLAQNIKSGDKVAIKVIDKEKIMKSGLVAHIKREISIL 126
Query: 60 KNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQY 119
+ +RH IV + ++Y ++EY G L + + G L E+ Y Q + + +
Sbjct: 127 RRVRHPYIVHLFEVMATKSKIYFVMEYVGGGELFNTVAKGRLPEETARRYFQQLISSVSF 186
Query: 120 LHEQGVIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMT 174
H +GV HRD+K NLLL +G +K++DFG+S R + + T+ G+P ++APEV+T
Sbjct: 187 CHGRGVYHRDLKPENLLLDNKGNLKVSDFGLSAVAEQLRQDGLCHTFCGTPAYIAPEVLT 246
Query: 175 GQGASTV-SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLS 233
+G +D+WS G + L+ G+ PF++ I E+ P S++ L+
Sbjct: 247 RKGYDAAKADVWSCGVILFVLMAGHIPFYDKNIMVMYKKIYKGEFRCPRWFSSDLVRLLT 306
Query: 234 RCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMTPSP 293
R N R T E++ + W KK K ++ YIE D D D + + S
Sbjct: 307 RLLDTNPDTRITIPEIMKNRWFKKGFK-----HVKFYIEDDKLCRED--EDEEEEASSSG 359
Query: 294 TKSPIQEDLAPADFRTLSVDQL 315
S + E A D + + + +
Sbjct: 360 RSSTVSESDAEFDVKRMGIGSM 381
>7293666 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 576
Score = 132 bits (332), Expect = 2e-30
Identities = 80/260 (30%), Positives = 130/260 (49%), Gaps = 7/260 (2%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE---DESELNEHMLEIDLLKNLRHQ 65
TY + G+G + Y + T+ A K + + ++ + EI + ++L H
Sbjct: 24 TYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHP 83
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDILKHGP-LLEDDTVNYVTQTLYGLQYLHEQG 124
NIV++ + + + +YI+LE C + S+ ++ K + E + Y+ Q + G++YLH+
Sbjct: 84 NIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNR 143
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQGASTV 181
+IHRD+K NL L + VK+ DFG++TRI T G+PN++APE++T +G S
Sbjct: 144 IIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFE 203
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
DIWS+G + LL G PPF + I EY P L D + Q N
Sbjct: 204 VDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPE 263
Query: 242 KRATAQELLAHIWLKKIQKP 261
R +LL +LK + P
Sbjct: 264 SRPAIGQLLNFEFLKGSKVP 283
>HsM4505103 [R] KOG0586 Serine/threonine protein kinase
Length = 713
Score = 131 bits (330), Expect = 4e-30
Identities = 83/257 (32%), Positives = 135/257 (52%), Gaps = 12/257 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L + IG+G + V A T + AIK I D+++LN L E+ ++K L
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKII---DKTQLNPTSLQKLFREVRIMKIL 110
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
H NIV+ I+ LY+I+EY + G + D L HG + E + + Q + +QY H
Sbjct: 111 NHPNIVKLFEVIETQKTLYLIMEYASGGKVFDYLVAHGRMKEKEARSKFRQIVSAVQYCH 170
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTR--INRMAMTYAGSPNWMAPEVMTGQGAS 179
++ ++HRD+KA NLLL + +K+ADFG S + T+ GSP + APE+ G+
Sbjct: 171 QKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYD 230
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D+WSLG + L++G+ PF + ++ +Y P +S +C++ L R
Sbjct: 231 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVL 290
Query: 239 NMFKRATAQELLAHIWL 255
N KR T ++++ W+
Sbjct: 291 NPIKRGTLEQIMKDRWI 307
>Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 661
Score = 131 bits (330), Expect = 4e-30
Identities = 76/253 (30%), Positives = 138/253 (54%), Gaps = 8/253 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI---EFEDESELNEHMLEIDLLKNLRHQN 66
Y L++ +G+G YG V RA +R + + AIK I + +DE ++ EI+++ +L H +
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
I+ + ++ II+EY ++G L D I + L E +T ++ Q + + Y H+ GV
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVMTGQG-ASTVS 182
+HRD+K N+LL + +K+ADFG+S + ++ T+ GSP + +PE++ G+
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFK 242
D W+LG + L+ G PF +++ I + EY P T ++ + + N +
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293
Query: 243 RATAQELLAHIWL 255
RAT +++ H W+
Sbjct: 294 RATIEDIANHWWV 306
>7299438 [R] KOG0586 Serine/threonine protein kinase
Length = 705
Score = 131 bits (330), Expect = 4e-30
Identities = 81/262 (30%), Positives = 135/262 (50%), Gaps = 12/262 (4%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EID 57
N +G Y + + +G+G + V A+ T + AIK I D+++LN E+
Sbjct: 91 NGNGNGVYKIIKTLGKGNFAKVKLAIHVPTGREVAIKVI---DKTQLNTSARQKLYREVK 147
Query: 58 LLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYG 116
++K L H NIV I+ LY+++EY +RG L D ++K+G + E D Q +
Sbjct: 148 IMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSA 207
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMT 174
+QY H + V+HRD+KA NLLL + +K+ADFG N T+ GSP + APE+
Sbjct: 208 IQYCHSKFVVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFM 267
Query: 175 GQG-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLS 233
G+ A D WSLG + L++G+ PF + ++ +Y P +S +C++ +
Sbjct: 268 GRKYAGPEVDAWSLGVVLYTLVSGSLPFDGGTLKELRERVLRGKYRVPYYISMDCENLMR 327
Query: 234 RCFQKNMFKRATAQELLAHIWL 255
+ N KR + +++ W+
Sbjct: 328 KFLVLNPAKRTSLSAVMSDKWI 349
>Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 476
Score = 131 bits (329), Expect = 5e-30
Identities = 86/261 (32%), Positives = 134/261 (50%), Gaps = 19/261 (7%)
Query: 9 TYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE----FEDESELNEHMLEIDLLKNLRH 64
T+ +V+G GA+ V+ +R T K A+K I+ F D S NE I +LK ++H
Sbjct: 22 TFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENE----IAVLKKIKH 77
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
+NIV + Y++++ + G L D IL+ G E D + Q L ++YLHE
Sbjct: 78 ENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHEN 137
Query: 124 GVIHRDIKAANLLL---TEEGIVKLADFGVS-TRINRMAMTYAGSPNWMAPEVMTGQGAS 179
G++HRD+K NLL E + + DFG+S N + T G+P ++APEV+ + S
Sbjct: 138 GIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYS 197
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPL--TLSAECKDFLSR 234
D WS+G LL G PPF+ ES + + E E+ P +S KDF+
Sbjct: 198 KAVDCWSIGVITYILLCGYPPFYE-ETESKLFEKIKEGYYEFESPFWDDISESAKDFICH 256
Query: 235 CFQKNMFKRATAQELLAHIWL 255
+K+ +R T ++ L+H W+
Sbjct: 257 LLEKDPNERYTCEKALSHPWI 277
>Hs13899225 [R] KOG0586 Serine/threonine protein kinase
Length = 688
Score = 131 bits (329), Expect = 5e-30
Identities = 86/259 (33%), Positives = 134/259 (51%), Gaps = 16/259 (6%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L + IG+G V A T + AIK I D+++LN L E+ ++K L
Sbjct: 57 GNYRLLRTIGKGNSAKVKLARHILTGREVAIKII---DKTQLNPSSLQKLFREVRIMKGL 113
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
H NIV+ I+ LY+++EY + G + D L HG + E + Q + + Y H
Sbjct: 114 NHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCH 173
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTR--INRMAMTYAGSPNWMAPEVMTGQGAS 179
++ ++HRD+KA NLLL E +K+ADFG S + T+ GSP + APE+ G+
Sbjct: 174 QKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYD 233
Query: 180 TVS-DIWSLGATVVELLTGNPPF--HNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCF 236
DIWSLG + L++G+ PF HNL + ++ +Y P +S +C+ L R
Sbjct: 234 GPEVDIWSLGVILYTLVSGSLPFDGHNL--KELRERVLRGKYRVPFYMSTDCESILRRFL 291
Query: 237 QKNMFKRATAQELLAHIWL 255
N KR T ++++ W+
Sbjct: 292 VLNPAKRCTLEQIMKDKWI 310
>CE28479 [T] KOG0583 Serine/threonine protein kinase
Length = 822
Score = 131 bits (329), Expect = 5e-30
Identities = 85/308 (27%), Positives = 156/308 (50%), Gaps = 30/308 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLLKNLRHQ 65
G Y + + IG+G + V A + AIK I+ D L + E+ ++K + H
Sbjct: 14 GLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHP 73
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
+IV+ ++ + LYI+ EYC+ G L + +++ G + E+ + ++T + YLH QG
Sbjct: 74 HIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQG 133
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVMTGQGASTV- 181
++HRD+KA N+LL + +K+ DFG S +++ T+ GSP + APE++ G +
Sbjct: 134 IVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMK 193
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
+DIWS+G + L+ G PF + ++++ P +S EC DF+ + N
Sbjct: 194 ADIWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPG 253
Query: 242 KRATAQELLAHIWLK----------------------KIQKPKSKIN--LAEYIEKDGKW 277
KR T Q +L H W+ +I++ +K+N + ++++ GKW
Sbjct: 254 KRYTIQNVLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKW 313
Query: 278 DVDFVLDS 285
+ ++D+
Sbjct: 314 SEEQIIDA 321
>7304283 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 7175
Score = 131 bits (329), Expect = 5e-30
Identities = 89/278 (32%), Positives = 139/278 (49%), Gaps = 21/278 (7%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y + + IG GA+GVV+R +R T A K I E + EID++ L HQ ++
Sbjct: 6138 YDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQKLIN 6197
Query: 70 YRGFIQKAHELYIILEYCARGSLRD-ILKHGPLL-EDDTVNYVTQTLYGLQYLHEQGVIH 127
+ E+ +ILE+ + G L + I G ++ E + +NY+ Q G++++HEQ +IH
Sbjct: 6198 LHDAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIH 6257
Query: 128 RDIKAANLLLTEEGI--VKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQGASTVSD 183
DIK N++ VKL DFG++TR+ N + G+ + APE++ + +D
Sbjct: 6258 LDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEVVKITTGTAEFAAPEIVNREPVGFYTD 6317
Query: 184 IWSLGATVVELLTGNPPF------HNLVNESAC---YAIVNEEYIPPLTLSAECKDFLSR 234
+W+ G LL+G PF L N AC + + + +YI S E KDF+ +
Sbjct: 6318 MWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESFKYI-----SEEAKDFIRK 6372
Query: 235 CFQKNMFKRATAQELLAHIWLKKIQKP-KSKINLAEYI 271
+N KR TA E L H WL K +IN Y+
Sbjct: 6373 LLVRNKEKRMTAHECLLHPWLTGDHSAMKQEINRDRYL 6410
>7293761 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 977
Score = 130 bits (328), Expect = 6e-30
Identities = 83/273 (30%), Positives = 146/273 (53%), Gaps = 28/273 (10%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G GA G V+ R N+ A+K+++ EL E +I L+ L H+NI++++G
Sbjct: 167 LGSGAQGAVFSG--RLKNETVAVKKVK-----ELKE--TDIKHLRKLDHENIIKFKGVCT 217
Query: 76 KAHELYIILEYCARGSLRDILKHGP-LLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAAN 134
++ II+E+C G L++ILK +L V++ Q G+QYLH +IHRD+K+ N
Sbjct: 218 QSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPN 277
Query: 135 LLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVMTGQGASTVSDIWSLGATVV 192
+L++ +VK++DFG S N ++ M++AG+ WMAPEV+ + S DIWS G +
Sbjct: 278 ILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLW 337
Query: 193 ELLTGNPPFHNLVNESACYAIVNE--EYIPPLTLSAECKDFLSRCFQKNMFKRATAQELL 250
E+LT P+ ++ + + + + N + + P T K + C++ R + +++L
Sbjct: 338 EMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQIL 397
Query: 251 AHI------WLKKIQKPKSKINLAEYIEKDGKW 277
+H+ L+K +K +Y E W
Sbjct: 398 SHLDIAGPELLRKTEK--------QYFETQKSW 422
>At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 465
Score = 130 bits (327), Expect = 8e-30
Identities = 84/264 (31%), Positives = 139/264 (51%), Gaps = 12/264 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN--EHM-LEIDLLKNLRHQN 66
+ + +V+G+GA+G VY+ K+ T++ A+K + + E N E+M E D+L + H
Sbjct: 134 FEVMKVVGKGAFGKVYQVRKKETSEIYAMKVMRKDHIMEKNHAEYMKAERDILTKIDHPF 193
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGLQYLHEQGV 125
IV+ + Q + LY++L++ G L L H L +D Y + + + +LHE+G+
Sbjct: 194 IVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGI 253
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQGASTVSD 183
+HRD+K N+L+ +G V L DFG++ N + + G+ +MAPE++ G+G +D
Sbjct: 254 MHRDLKPENILMDTDGHVMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAAD 313
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKR 243
WS+G + E+LTG PPF + IV ++ P LS E L QK +R
Sbjct: 314 WWSVGILLYEMLTGKPPFLGSKGKIQ-QKIVKDKIKLPQFLSNEAHAILKGLLQKEPERR 372
Query: 244 -----ATAQELLAHIWLKKIQKPK 262
+ A+E+ H W K I K
Sbjct: 373 LGSGLSGAEEIKQHKWFKGINWKK 396
>At1g01140 [T] KOG0583 Serine/threonine protein kinase
Length = 447
Score = 130 bits (327), Expect = 8e-30
Identities = 84/266 (31%), Positives = 130/266 (48%), Gaps = 10/266 (3%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED---ESELNEHMLEIDLLKNLRH 64
G Y + + +G G++ V A T AIK ++ E + + EI +K ++H
Sbjct: 17 GNYEMGRTLGEGSFAKVKYAKNTVTGDQAAIKILDREKVFRHKMVEQLKREISTMKLIKH 76
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
N+VE + ++YI+LE G L D I + G L ED+ Y Q + + Y H +
Sbjct: 77 PNVVEIIEVMASKTKIYIVLELVNGGELFDKIAQQGRLKEDEARRYFQQLINAVDYCHSR 136
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVS-----TRINRMAMTYAGSPNWMAPEVMTGQG- 177
GV HRD+K NL+L G++K++DFG+S R + + T G+PN++APEV++ +G
Sbjct: 137 GVYHRDLKPENLILDANGVLKVSDFGLSAFSRQVREDGLLHTACGTPNYVAPEVLSDKGY 196
Query: 178 ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQ 237
+D+WS G + L+ G PF + I E+ P S K + R +
Sbjct: 197 DGAAADVWSCGVILFVLMAGYLPFDEPNLMTLYKRICKAEFSCPPWFSQGAKRVIKRILE 256
Query: 238 KNMFKRATAQELLAHIWLKKIQKPKS 263
N R + ELL W KK KP S
Sbjct: 257 PNPITRISIAELLEDEWFKKGYKPPS 282
>At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 269
Score = 130 bits (326), Expect = 1e-29
Identities = 79/257 (30%), Positives = 137/257 (52%), Gaps = 7/257 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML--EIDLLKNLRHQNI 67
Y + +++G G++G VY+ ++ T + A+K I + +++ + H L EI++L+ L+H+NI
Sbjct: 6 YHVIELVGEGSFGRVYKGRRKYTGQTVAMKFIMKQGKTDKDIHSLRQEIEILRKLKHENI 65
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLY-GLQYLHEQGVI 126
+E + A E ++ E+ A+G L +IL+ L ++ V + + L L YLH +I
Sbjct: 66 IEMLDSFENAREFCVVTEF-AQGELFEILEDDKCLPEEQVQAIAKQLVKALDYLHSNRII 124
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRINRMAM---TYAGSPNWMAPEVMTGQGASTVSD 183
HRD+K N+L+ +VKL DFG + ++ + + G+P +MAPE++ Q D
Sbjct: 125 HRDMKPQNILIGAGSVVKLCDFGFARAMSTNTVVLRSIKGTPLYMAPELVKEQPYDRTVD 184
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKR 243
+WSLG + EL G PPF+ + IV + P +S + FL K R
Sbjct: 185 LWSLGVILYELYVGQPPFYTNSVYALIRHIVKDPVKYPDEMSTYFESFLKGLLNKEPHSR 244
Query: 244 ATAQELLAHIWLKKIQK 260
T L H ++K+ Q+
Sbjct: 245 LTWPALREHPFVKETQE 261
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 130 bits (326), Expect = 1e-29
Identities = 85/257 (33%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L + IG+G + V A T K AIK I D+++LN L E+ ++K L
Sbjct: 149 GKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKII---DKTQLNPGSLQKLFREVRIMKML 205
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLH 121
H NIV+ I+ LY+I+EY + G + D L HG + E + Q + +QY H
Sbjct: 206 DHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCH 265
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM--TYAGSPNWMAPEVMTGQGAS 179
++ +IHRD+KA NLLL E +K+ADFG S + T+ GSP + APE+ G+
Sbjct: 266 QKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYD 325
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D+WSLG + L++G+ PF ++ +Y P +S +C++ L +
Sbjct: 326 GPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVL 385
Query: 239 NMFKRATAQELLAHIWL 255
N KRA+ + ++ W+
Sbjct: 386 NPAKRASLETIMGDKWM 402
>Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1050
Score = 129 bits (325), Expect = 1e-29
Identities = 87/263 (33%), Positives = 136/263 (51%), Gaps = 17/263 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNK-PCAIKQIEFEDESELNEHM-LEIDLLKNLRHQNI 67
++ K +IG GA+ VV++ R + A+K I ++ ++ + EI +LK L+H+NI
Sbjct: 16 FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENI 75
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYG-LQYLHEQGVI 126
V F + A+ +Y+++EYC G L D L L +DT+ Q + G ++ LH +G+I
Sbjct: 76 VALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGII 135
Query: 127 HRDIKAANLLLTEEG---------IVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTG 175
HRD+K N+LL+ VK+ADFG + + N MA T GSP +MAPEV+
Sbjct: 136 HRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMS 195
Query: 176 QGASTVSDIWSLGATVVELLTGNPPFH-NLVNESACYAIVNEEYIP--PLTLSAECKDFL 232
Q +D+WS+G V + LTG PF + + + N+ +P P SA + L
Sbjct: 196 QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLL 255
Query: 233 SRCFQKNMFKRATAQELLAHIWL 255
Q+N R E H +L
Sbjct: 256 LALLQRNHKDRMDFDEFFHHPFL 278
>Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 129 bits (325), Expect = 1e-29
Identities = 70/201 (34%), Positives = 109/201 (53%), Gaps = 4/201 (1%)
Query: 54 LEIDLLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLL-EDDTVNYVTQ 112
+EI + ++L HQ++V + GF + ++++LE C R SL ++ K L E + Y+ Q
Sbjct: 100 MEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQ 159
Query: 113 TLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMA 169
+ G QYLH VIHRD+K NL L E+ VK+ DFG++T++ T G+PN++A
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIA 219
Query: 170 PEVMTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECK 229
PEV++ +G S D+WS+G + LL G PPF + I EY P ++
Sbjct: 220 PEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAA 279
Query: 230 DFLSRCFQKNMFKRATAQELL 250
+ + Q + R T ELL
Sbjct: 280 SLIQKMLQTDPTARPTINELL 300
>CE27573 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1420
Score = 129 bits (325), Expect = 1e-29
Identities = 87/263 (33%), Positives = 133/263 (50%), Gaps = 26/263 (9%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
+AL I G++G V+RA+ +++ A K + + E+ EI++ + L H+N+V+
Sbjct: 1125 WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIES-EINIFRQLIHENLVK 1183
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRD 129
Y G + ++ I +EYC++G+L I HG + Y L +QYLH +IHRD
Sbjct: 1184 YYGVQVEDSDVIIFMEYCSQGTLERIC-HGKMDLKMVRQYTNSLLRAVQYLHSHKIIHRD 1242
Query: 130 IKAANLLLTEEGIVKLADFGVSTRINRMAMTY------AGSPNWMAPEV----------- 172
IK AN+ L + ++KL DFG S+R+ + Y AG+P +MAPE+
Sbjct: 1243 IKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTG 1302
Query: 173 -MTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSA----E 227
+G G S DIW+LGATVV ++TG PF +A+ + P A +
Sbjct: 1303 SYSGYGRSV--DIWALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPD 1360
Query: 228 CKDFLSRCFQKNMFKRATAQELL 250
K F CF+ R TA ELL
Sbjct: 1361 VKRFFDNCFEFLPNDRPTAAELL 1383
>CE07737 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1418
Score = 129 bits (325), Expect = 1e-29
Identities = 87/263 (33%), Positives = 133/263 (50%), Gaps = 26/263 (9%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
+AL I G++G V+RA+ +++ A K + + E+ EI++ + L H+N+V+
Sbjct: 1125 WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIES-EINIFRQLIHENLVK 1183
Query: 70 YRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRD 129
Y G + ++ I +EYC++G+L I HG + Y L +QYLH +IHRD
Sbjct: 1184 YYGVQVEDSDVIIFMEYCSQGTLERIC-HGKMDLKMVRQYTNSLLRAVQYLHSHKIIHRD 1242
Query: 130 IKAANLLLTEEGIVKLADFGVSTRINRMAMTY------AGSPNWMAPEV----------- 172
IK AN+ L + ++KL DFG S+R+ + Y AG+P +MAPE+
Sbjct: 1243 IKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTG 1302
Query: 173 -MTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSA----E 227
+G G S DIW+LGATVV ++TG PF +A+ + P A +
Sbjct: 1303 SYSGYGRSV--DIWALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPD 1360
Query: 228 CKDFLSRCFQKNMFKRATAQELL 250
K F CF+ R TA ELL
Sbjct: 1361 VKRFFDNCFEFLPNDRPTAAELL 1383
>At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 471
Score = 129 bits (325), Expect = 1e-29
Identities = 84/264 (31%), Positives = 139/264 (51%), Gaps = 12/264 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN--EHM-LEIDLLKNLRHQN 66
+ + +V+G+GA+G VY+ K+ T++ A+K + + E N E+M E D+L + H
Sbjct: 140 FEVLKVVGQGAFGKVYQVRKKDTSEIYAMKVMRKDKIVEKNHAEYMKAERDILTKIDHPF 199
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGLQYLHEQGV 125
IV+ + Q + LY++L++ G L L H L +D Y + + + +LHE+G+
Sbjct: 200 IVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGI 259
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQGASTVSD 183
+HRD+K N+L+ +G V L DFG++ N + + G+ +MAPE++ G+G +D
Sbjct: 260 MHRDLKPENILMDVDGHVMLTDFGLAKEFEENTRSNSMCGTTEYMAPEIVRGKGHDKAAD 319
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKR 243
WS+G + E+LTG PPF + IV ++ P LS E L QK +R
Sbjct: 320 WWSVGILLYEMLTGKPPFLGSKGKIQ-QKIVKDKIKLPQFLSNEAHALLKGLLQKEPERR 378
Query: 244 -----ATAQELLAHIWLKKIQKPK 262
+ A+E+ H W K I K
Sbjct: 379 LGSGPSGAEEIKKHKWFKAINWKK 402
>7299437 [R] KOG0586 Serine/threonine protein kinase
Length = 604
Score = 129 bits (325), Expect = 1e-29
Identities = 79/259 (30%), Positives = 134/259 (51%), Gaps = 6/259 (2%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML--EIDLLK 60
N +G Y + + +G+G + V A+ T + AIK I+ + + L E++++K
Sbjct: 56 NGNGYGVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMK 115
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQY 119
L H NIV I+ LY+++EY + G L + L K+G + E D Q + ++Y
Sbjct: 116 KLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEY 175
Query: 120 LHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVMTGQG 177
H + ++HRD+KA NLLL ++ +K+ADFG ST A T+ GSP + APE+ G+
Sbjct: 176 CHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKK 235
Query: 178 ASTVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCF 236
S D WSLG + L++G+ PF + ++ +Y P +S EC+ + +
Sbjct: 236 YSGPEVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFL 295
Query: 237 QKNMFKRATAQELLAHIWL 255
N +R + ++A W+
Sbjct: 296 VLNPTQRTSLSAVMADRWI 314
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 129 bits (324), Expect = 2e-29
Identities = 87/288 (30%), Positives = 145/288 (50%), Gaps = 17/288 (5%)
Query: 2 DNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLL 59
D + G Y L + IG+G + V A T AIK I+ + S L + E+ ++
Sbjct: 114 DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIM 173
Query: 60 KNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQ 118
K L H NIV+ ++ LY++LEY + G + D L HG + E + Q + +Q
Sbjct: 174 KQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 233
Query: 119 YLHEQGVIHRDIKAANLLLTEEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVMTGQ 176
YLH + +IHRD+KA NLLL ++ +K+ADFG S + T+ GSP + APE+ +G+
Sbjct: 234 YLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGK 293
Query: 177 GASTVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRC 235
D+WSLG + L++G+ PF + ++ +Y P +S +C++ L +
Sbjct: 294 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKF 353
Query: 236 FQKNMFKRATAQELLAHIWLKK----------IQKPKSKINLAEYIEK 273
N +R++ ++ W+ I+ PK +I+ + IEK
Sbjct: 354 LVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQID-EQRIEK 400
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 129 bits (324), Expect = 2e-29
Identities = 87/288 (30%), Positives = 145/288 (50%), Gaps = 17/288 (5%)
Query: 2 DNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLL 59
D + G Y L + IG+G + V A T AIK I+ + S L + E+ ++
Sbjct: 162 DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIM 221
Query: 60 KNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQ 118
K L H NIV+ ++ LY++LEY + G + D L HG + E + Q + +Q
Sbjct: 222 KQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQ 281
Query: 119 YLHEQGVIHRDIKAANLLLTEEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVMTGQ 176
YLH + +IHRD+KA NLLL ++ +K+ADFG S + T+ GSP + APE+ +G+
Sbjct: 282 YLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGK 341
Query: 177 GASTVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRC 235
D+WSLG + L++G+ PF + ++ +Y P +S +C++ L +
Sbjct: 342 KYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKF 401
Query: 236 FQKNMFKRATAQELLAHIWLKK----------IQKPKSKINLAEYIEK 273
N +R++ ++ W+ I+ PK +I+ + IEK
Sbjct: 402 LVINPQRRSSLDNIMKDRWMNVGYEDDELKPFIEPPKDQID-EQRIEK 448
>CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 615
Score = 129 bits (324), Expect = 2e-29
Identities = 78/252 (30%), Positives = 127/252 (49%), Gaps = 6/252 (2%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIE--FEDESELNEHML-EIDLLKNLRHQNIVEYRG 72
+G G + + K N A+K + +S E + E+++ + L H+NIV++
Sbjct: 41 LGEGGFAHCFEFRKLDCNDRLAVKVVPKVILLKSTAREKLTREVEIHRQLSHRNIVQFHH 100
Query: 73 FIQKAHELYIILEYCARGSLRDILKH-GPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIK 131
F + + +Y LE C++ SL ++ K GPL E + Y Q G+++LH +IHRD+K
Sbjct: 101 FFEDSQNVYFTLELCSKNSLMELNKQRGPLTEHEARFYTIQVAEGVKHLHNLQIIHRDLK 160
Query: 132 AANLLLTEEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGA 189
NL L E VK+ DFG++T N MT G+PN++APEV+ G + DIW++G
Sbjct: 161 LGNLFLNEHLQVKIGDFGLATFCEKNEKKMTRGGTPNYIAPEVLNETGHAFEVDIWAIGC 220
Query: 190 TVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRATAQEL 249
+ LL G+PPF + + I N +Y+ P S + +R TA+ +
Sbjct: 221 ILYVLLFGSPPFESRRVQETYVRIKNNDYVVPENASPTANRLIRSLLDPVPDRRPTAEAV 280
Query: 250 LAHIWLKKIQKP 261
L + K +P
Sbjct: 281 LLDQFFKTTIEP 292
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 128 bits (322), Expect = 3e-29
Identities = 81/257 (31%), Positives = 132/257 (50%), Gaps = 5/257 (1%)
Query: 4 SIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI-EFEDESELNEHML--EIDLLK 60
++A + + + +G+G +G VY A ++ + A+K + + + E EH L E+++
Sbjct: 126 AVALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQS 185
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQY 119
+LRH NI+ G+ A +Y+ILEY G++ R++ K E T N + L Y
Sbjct: 186 HLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTANLYNRIANALSY 245
Query: 120 LHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRI-NRMAMTYAGSPNWMAPEVMTGQGA 178
H + VIHRDIK NLLL G +K+ADFG S + T G+ +++ PE++ G+
Sbjct: 246 CHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMH 305
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D+WSLG E L G PPF + I E+ P ++ +D +SR +
Sbjct: 306 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKH 365
Query: 239 NMFKRATAQELLAHIWL 255
N +R +E+L H W+
Sbjct: 366 NPSQRPMLREVLEHPWI 382
>Hs9845489 [R] KOG0586 Serine/threonine protein kinase
Length = 691
Score = 128 bits (322), Expect = 3e-29
Identities = 81/257 (31%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L + IG+G + V A T K A+K I D+++LN L E+ ++K L
Sbjct: 18 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKII---DKTQLNSSSLQKLFREVRIMKVL 74
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
H NIV+ I+ LY+++EY + G + D L HG + E + Q + +QY H
Sbjct: 75 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 134
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTR--INRMAMTYAGSPNWMAPEVMTGQGAS 179
++ ++HRD+KA NLLL + +K+ADFG S T+ GSP + APE+ G+
Sbjct: 135 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 194
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D+WSLG + L++G+ PF + ++ +Y P +S +C++ L +
Sbjct: 195 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLIL 254
Query: 239 NMFKRATAQELLAHIWL 255
N KR T ++++ W+
Sbjct: 255 NPSKRGTLEQIMKDRWM 271
>Hs9845487 [R] KOG0586 Serine/threonine protein kinase
Length = 745
Score = 128 bits (322), Expect = 3e-29
Identities = 81/257 (31%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L + IG+G + V A T K A+K I D+++LN L E+ ++K L
Sbjct: 18 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKII---DKTQLNSSSLQKLFREVRIMKVL 74
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
H NIV+ I+ LY+++EY + G + D L HG + E + Q + +QY H
Sbjct: 75 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 134
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTR--INRMAMTYAGSPNWMAPEVMTGQGAS 179
++ ++HRD+KA NLLL + +K+ADFG S T+ GSP + APE+ G+
Sbjct: 135 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 194
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D+WSLG + L++G+ PF + ++ +Y P +S +C++ L +
Sbjct: 195 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLIL 254
Query: 239 NMFKRATAQELLAHIWL 255
N KR T ++++ W+
Sbjct: 255 NPSKRGTLEQIMKDRWM 271
>Hs8923922 [R] KOG0586 Serine/threonine protein kinase
Length = 795
Score = 128 bits (322), Expect = 3e-29
Identities = 79/257 (30%), Positives = 135/257 (51%), Gaps = 12/257 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L++ IG+G + V A T + A+K I D+++LN L E+ ++K L
Sbjct: 58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKII---DKTQLNPTSLQKLFREVRIMKIL 114
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
H NIV+ I+ LY+++EY + G + D L HG + E + Q + +QY H
Sbjct: 115 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 174
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTR--INRMAMTYAGSPNWMAPEVMTGQGAS 179
++ ++HRD+KA NLLL + +K+ADFG S + T+ GSP + APE+ G+
Sbjct: 175 QKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYD 234
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D+WSLG + L++G+ PF + ++ +Y P +S +C++ L +
Sbjct: 235 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVL 294
Query: 239 NMFKRATAQELLAHIWL 255
N KR + ++++ W+
Sbjct: 295 NPIKRGSLEQIMKDRWM 311
>Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1036
Score = 128 bits (322), Expect = 3e-29
Identities = 88/272 (32%), Positives = 144/272 (52%), Gaps = 19/272 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRG-TNKPCAIKQIEFEDESELNEHML--EIDLLKNLRHQN 66
Y+ + ++G GA+ VV+R R T+ AIK I ++ S+ ++ +L EI +LK L+H+N
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSK-SQILLGKEIKILKELQHEN 67
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGLQYLHEQGV 125
IV + + +++++EYC G L D L+ L +DT+ ++ Q ++ LH +G+
Sbjct: 68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGI 127
Query: 126 IHRDIKAANLLLTE--------EGI-VKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMT 174
IHRD+K N+LL+ GI +K+ADFG + + N MA T GSP +MAPEV+
Sbjct: 128 IHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIM 187
Query: 175 GQGASTVSDIWSLGATVVELLTGNPPFH-NLVNESACYAIVNEEYIP--PLTLSAECKDF 231
Q +D+WS+G + + L G PPF N + + N +P P S +
Sbjct: 188 SQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANL 247
Query: 232 LSRCFQKNMFKRATAQELLAHIWLKKIQKPKS 263
L Q+N R + +H +L++ KS
Sbjct: 248 LLGLLQRNQKDRMDFEAFFSHPFLEQGPVKKS 279
>Hs22062450 [R] KOG0586 Serine/threonine protein kinase
Length = 787
Score = 128 bits (322), Expect = 3e-29
Identities = 81/257 (31%), Positives = 133/257 (51%), Gaps = 12/257 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L + IG+G + V A T K A+K I D+++LN L E+ ++K L
Sbjct: 51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKII---DKTQLNSSSLQKLFREVRIMKVL 107
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
H NIV+ I+ LY+++EY + G + D L HG + E + Q + +QY H
Sbjct: 108 NHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCH 167
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTR--INRMAMTYAGSPNWMAPEVMTGQGAS 179
++ ++HRD+KA NLLL + +K+ADFG S T+ GSP + APE+ G+
Sbjct: 168 QKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYD 227
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D+WSLG + L++G+ PF + ++ +Y P +S +C++ L +
Sbjct: 228 GPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLIL 287
Query: 239 NMFKRATAQELLAHIWL 255
N KR T ++++ W+
Sbjct: 288 NPSKRGTLEQIMKDRWM 304
>At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 561
Score = 128 bits (322), Expect = 3e-29
Identities = 86/263 (32%), Positives = 126/263 (47%), Gaps = 16/263 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
Y L + IG G V+RA+ N AIK ++ E ++L+ E+ + + H N++
Sbjct: 16 YKLYEEIGDGVSATVHRALCIPLNVVVAIKVLDLEKCNNDLDGIRREVQTMSLINHPNVL 75
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHG---PLLEDDTVNYVTQTLYGLQYLHEQGV 125
+ H+L++++ Y A GS I+K E + +TL L YLH G
Sbjct: 76 QAHCSFTTGHQLWVVMPYMAGGSCLHIIKSSYPDGFEEPVIATLLRETLKALVYLHAHGH 135
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRI------NRMAMTYAGSPNWMAPEVMTG-QGA 178
IHRD+KA N+LL G VKLADFGVS + R T+ G+P WMAPEVM G
Sbjct: 136 IHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQRSRNTFVGTPCWMAPEVMQQLHGY 195
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNE-----EYIPPLTLSAECKDFLS 233
+D+WS G T +EL G+ PF + +Y S K+ +
Sbjct: 196 DFKADVWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDKRFSKAFKEMVG 255
Query: 234 RCFQKNMFKRATAQELLAHIWLK 256
C K+ KR T+++LL H + K
Sbjct: 256 TCLVKDPKKRPTSEKLLKHPFFK 278
>HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 128 bits (321), Expect = 4e-29
Identities = 75/245 (30%), Positives = 137/245 (55%), Gaps = 14/245 (5%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGF 73
Q +G GA G V+ + R + A+K++ E+++ L+ L+H NI+ ++G
Sbjct: 129 QWVGSGAQGAVF--LGRFHGEEVAVKKVRDLKETDIKH-------LRKLKHPNIITFKGV 179
Query: 74 IQKAHELYIILEYCARGSLRDILKHG-PLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKA 132
+A I++E+CA+G L ++L+ G P+ V++ G+ YLH +IHRD+K+
Sbjct: 180 CTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKS 239
Query: 133 ANLLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+L+T + +VK++DFG S ++ + M++AG+ WMAPEV+ + S DIWS G
Sbjct: 240 PNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVV 299
Query: 191 VVELLTGNPPFHNLVNESACYAI-VNEEYIP-PLTLSAECKDFLSRCFQKNMFKRATAQE 248
+ ELLTG P+ ++ + + + + N ++P P + K L +C+ R + ++
Sbjct: 300 LWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQ 359
Query: 249 LLAHI 253
+L H+
Sbjct: 360 ILLHL 364
>Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 128 bits (321), Expect = 4e-29
Identities = 75/245 (30%), Positives = 137/245 (55%), Gaps = 14/245 (5%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGF 73
Q +G GA G V+ + R + A+K++ E+++ L+ L+H NI+ ++G
Sbjct: 129 QWVGSGAQGAVF--LGRFHGEEVAVKKVRDLKETDIKH-------LRKLKHPNIITFKGV 179
Query: 74 IQKAHELYIILEYCARGSLRDILKHG-PLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKA 132
+A I++E+CA+G L ++L+ G P+ V++ G+ YLH +IHRD+K+
Sbjct: 180 CTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKS 239
Query: 133 ANLLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+L+T + +VK++DFG S ++ + M++AG+ WMAPEV+ + S DIWS G
Sbjct: 240 PNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVV 299
Query: 191 VVELLTGNPPFHNLVNESACYAI-VNEEYIP-PLTLSAECKDFLSRCFQKNMFKRATAQE 248
+ ELLTG P+ ++ + + + + N ++P P + K L +C+ R + ++
Sbjct: 300 LWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQ 359
Query: 249 LLAHI 253
+L H+
Sbjct: 360 ILLHL 364
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 127 bits (320), Expect = 5e-29
Identities = 86/281 (30%), Positives = 142/281 (49%), Gaps = 24/281 (8%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEF--EDESELNEHMLEIDLLKNLRHQNIVEYRG 72
++G GA G V + + +K A+K I D + E+ ++ + + IV Y G
Sbjct: 226 ILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYG 285
Query: 73 FI--QKAHELYIILEYCARGSL----RDILKHGPLLEDDTVNYVTQT-LYGLQYLHEQGV 125
+ +YI +EY SL +++L+ G + + + + + L GL YLHE+ V
Sbjct: 286 MFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKV 345
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVS-TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDI 184
IHRDIK N+LL E G VKL DFGVS +N +A T+ G+ +MAPE + GQ S SD+
Sbjct: 346 IHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDV 405
Query: 185 WSLGATVVELLTGN------------PPFHNLVNESACYAIVNEEYIPPLTLSAECKDFL 232
WSLG T++E+ G PF L+ + +E + S K F+
Sbjct: 406 WSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFI 465
Query: 233 SRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEK 273
C +K+ +R + ++++ H W+K + K +N+ +++ K
Sbjct: 466 DYCLKKDSRERPSPRQMINHPWIK--GQMKKNVNMEKFVRK 504
>CE17284 [T] KOG0583 Serine/threonine protein kinase
Length = 726
Score = 127 bits (320), Expect = 5e-29
Identities = 84/260 (32%), Positives = 133/260 (50%), Gaps = 9/260 (3%)
Query: 5 IAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES-ELNEHMLEIDLLKNLR 63
+ G YA+ +G G +G V A TN+ AIK I+ + +L E+D L+NL
Sbjct: 6 VLQGFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDKKQLGHDLPRVQTEMDALRNLS 65
Query: 64 HQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHE 122
HQNI +I+ + +I++EYC+ G + D I++ L E + ++ Q + + ++H
Sbjct: 66 HQNICRLYHYIETEDKFFIVMEYCSGGEMFDYIVRKERLEESEARHFFRQLVSAIAFVHS 125
Query: 123 QGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM------TYAGSPNWMAPEVMTG- 175
QG HRD+K NLLLTE+ +KL DFG+ + + + T GSP + APE++ G
Sbjct: 126 QGYAHRDLKPENLLLTEDLHLKLIDFGLCAKTEKGRIDKHNLDTCCGSPAYAAPELIQGL 185
Query: 176 QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRC 235
Q +D+WS+G + LL G PF + + I + + P LS K L
Sbjct: 186 QYKGNEADVWSMGILLYTLLVGALPFEDDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAM 245
Query: 236 FQKNMFKRATAQELLAHIWL 255
Q +R + ++LL H WL
Sbjct: 246 LQVVPERRISVKKLLEHDWL 265
>At2g34180 [T] KOG0583 Serine/threonine protein kinase
Length = 502
Score = 127 bits (320), Expect = 5e-29
Identities = 96/321 (29%), Positives = 153/321 (46%), Gaps = 15/321 (4%)
Query: 4 SIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHML-EIDLLK 60
SI Y + +++G G++ VY A + + AIK I+ E +S L H+ EI +L+
Sbjct: 51 SILMDKYEIGKLLGHGSFAKVYLARNIHSGEDVAIKVIDKEKIVKSGLAGHIKREISILR 110
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYL 120
+RH IV + ++YI++EY G L + + G L E Y Q + + +
Sbjct: 111 RVRHPYIVHLLEVMATKTKIYIVMEYVRGGELYNTVARGRLREGTARRYFQQLISSVAFC 170
Query: 121 HEQGVIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTG 175
H +GV HRD+K NLLL ++G VK++DFG+S + + T+ G+P ++APEV+T
Sbjct: 171 HSRGVYHRDLKLENLLLDDKGNVKVSDFGLSVVSEQLKQEGICQTFCGTPAYLAPEVLTR 230
Query: 176 QG-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSR 234
+G +DIWS G + L+ G PF + I ++ P S E ++R
Sbjct: 231 KGYEGAKADIWSCGVILFVLMAGYLPFDDKNILVMYTKIYKGQFKCPKWFSPELARLVTR 290
Query: 235 CFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMTPSPT 294
N R T E++ H W KK K ++ YIE D D D + + S
Sbjct: 291 MLDTNPDTRITIPEIMKHRWFKKGFK-----HVKFYIENDKLCREDDDNDDDDSSSLSSG 345
Query: 295 KSPIQEDLAPADFRTLSVDQL 315
+S + A+F VD +
Sbjct: 346 RSSTASE-GDAEFDIKRVDSM 365
>Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 966
Score = 127 bits (319), Expect = 7e-29
Identities = 78/245 (31%), Positives = 134/245 (53%), Gaps = 14/245 (5%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGF 73
Q +G GA G V+ R + AIK++ ++E+++ L+ L+H NI+ ++G
Sbjct: 172 QWLGSGAQGAVFLGKFRA--EEVAIKKVREQNETDIKH-------LRKLKHPNIIAFKGV 222
Query: 74 IQKAHELYIILEYCARGSLRDILKHGPLLEDDT-VNYVTQTLYGLQYLHEQGVIHRDIKA 132
+A II+EYCA G L ++L+ G + V++ T G+ YLH +IHRD+K+
Sbjct: 223 CTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKS 282
Query: 133 ANLLLTEEGIVKLADFGVSTRINRMA--MTYAGSPNWMAPEVMTGQGASTVSDIWSLGAT 190
N+L+T VK++DFG S ++ + M++AG+ WMAPEV+ + S DIWS G
Sbjct: 283 PNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVV 342
Query: 191 VVELLTGNPPFHNLVNESACYAI-VNEEYIP-PLTLSAECKDFLSRCFQKNMFKRATAQE 248
+ ELLTG P+ ++ + + + + N ++P P T K + + +Q R + ++
Sbjct: 343 LWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQ 402
Query: 249 LLAHI 253
L H+
Sbjct: 403 TLMHL 407
>At5g55090 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 448
Score = 127 bits (319), Expect = 7e-29
Identities = 86/251 (34%), Positives = 143/251 (56%), Gaps = 15/251 (5%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGF- 73
+IGRG+ V + + A+K EF + L E +L L IV+Y G
Sbjct: 11 IIGRGSTATVSLGITNSGDF-FAVKSAEFSSSAFLQR---EQSILSKLSSPYIVKYIGSN 66
Query: 74 IQKAHE--LY-IILEYCARGSLRDILKH--GPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
+ K ++ +Y +++EY + GSL D++K+ G L E +Y Q L GL YLH+QG++H
Sbjct: 67 VTKENDKLMYNLLMEYVSGGSLHDLIKNSGGKLPEPLIRSYTRQILKGLMYLHDQGIVHC 126
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRINRMA-MTYAGSPNWMAPEVMTGQGASTVSDIWSL 187
D+K+ N+++ E I K+ D G + + + ++G+P +M+PEV G+ S +D+W+L
Sbjct: 127 DVKSQNVMIGGE-IAKIVDLGCAKTVEENENLEFSGTPAFMSPEVARGEEQSFPADVWAL 185
Query: 188 GATVVELLTGNPPFHNLVN-ESACYAI--VNEEYIPPLTLSAECKDFLSRCFQKNMFKRA 244
G TV+E+ TG+ P+ L + +A Y I E + P+ LS + +DFL +C +K+ +R
Sbjct: 186 GCTVIEMATGSSPWPELNDVVAAIYKIGFTGESPVIPVWLSEKGQDFLRKCLRKDPKQRW 245
Query: 245 TAQELLAHIWL 255
T +ELL H +L
Sbjct: 246 TVEELLQHPFL 256
>At3g29160 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 127 bits (319), Expect = 7e-29
Identities = 85/254 (33%), Positives = 128/254 (49%), Gaps = 7/254 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHML-EIDLLKNLRHQN 66
Y L + +G G++G V A T AIK + E+ E + EI +L+ H +
Sbjct: 20 YKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPH 79
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
I+ I+ ++Y+++EY G L D I++ G L ED+ N+ Q + G++Y H V
Sbjct: 80 IIRQYEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMV 139
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVMTGQ-GASTVS 182
+HRD+K NLLL +K+ADFG+S R T GSPN+ APEV++G+ A
Sbjct: 140 VHRDLKPENLLLDSRCNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEV 199
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFK 242
D+WS G + LL G PF + + I Y P LS+E +D + R + K
Sbjct: 200 DVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVK 259
Query: 243 RATAQELLAHIWLK 256
R T E+ H W +
Sbjct: 260 RITIPEIRQHRWFQ 273
>At1g48260 [T] KOG0583 Serine/threonine protein kinase
Length = 432
Score = 127 bits (319), Expect = 7e-29
Identities = 89/266 (33%), Positives = 125/266 (46%), Gaps = 10/266 (3%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN---EHMLEIDLLKNLRH 64
G Y L + +G G V A+ T + AIK IE + LN + EI LK L+H
Sbjct: 9 GKYELGRTLGEGNSAKVKFAIDTLTGESFAIKIIEKSCITRLNVSFQIKREIRTLKVLKH 68
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
NIV + ++Y++LE G L D I+ G L E Q + G+ Y H +
Sbjct: 69 PNIVRLHEVLASKTKIYMVLECVTGGDLFDRIVSKGKLSETQGRKMFQQLIDGVSYCHNK 128
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTGQG- 177
GV HRD+K N+LL +G +K+ DFG+S R + + T GSPN++APEV+ +G
Sbjct: 129 GVFHRDLKLENVLLDAKGHIKITDFGLSALSQHYREDGLLHTTCGSPNYVAPEVLANEGY 188
Query: 178 ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQ 237
SDIWS G + +LTG PF + C I + P +S K + R
Sbjct: 189 DGAASDIWSCGVILYVILTGCLPFDDANLAVICRKIFKGDPPIPRWISLGAKTMIKRMLD 248
Query: 238 KNMFKRATAQELLAHIWLKKIQKPKS 263
N R T + AH W K P +
Sbjct: 249 PNPVTRVTIAGIKAHDWFKHDYTPSN 274
>At1g07150 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 499
Score = 127 bits (319), Expect = 7e-29
Identities = 86/258 (33%), Positives = 140/258 (53%), Gaps = 21/258 (8%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLE--IDLLKNLR-HQNIVEYRG 72
IGRG +G V A+ + + A+K ++ LE I + ++L+ H IV++ G
Sbjct: 29 IGRGCFGAVSTAISKTNGEVFAVKSVDLATSLPTQSESLENEISVFRSLKPHPYIVKFLG 88
Query: 73 F-IQKA-----HELYIILEYCARGSLRDILKH--GPLLEDDTV--NYVTQTLYGLQYLHE 122
+ K LY LEY G D+ H G +ED+T+ Y + L+++H
Sbjct: 89 DGVSKEGTTTFRNLY--LEYLPNG---DVASHRAGGKIEDETLLQRYTACLVSALRHVHS 143
Query: 123 QGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN--RMAMTYAGSPNWMAPEVMTGQGAST 180
QG +H D+KA N+L+++ +VKLADFG + RI+ R +T GSP WMAPEV+ +
Sbjct: 144 QGFVHCDVKARNILVSQSSMVKLADFGSAFRIHTPRALITPRGSPLWMAPEVIRREYQGP 203
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEY-IPPLTLSAECKDFLSRCFQKN 239
SD+WSLG T++E+ TG P + + +S ++E + P LS +DFL +C +++
Sbjct: 204 ESDVWSLGCTIIEMFTGKPAWEDHGIDSLSRISFSDELPVFPSKLSEIGRDFLEKCLKRD 263
Query: 240 MFKRATAQELLAHIWLKK 257
+R + +LL H +L +
Sbjct: 264 PNQRWSCDQLLQHPFLSQ 281
>7303915 [T] KOG0694 Serine/threonine protein kinase
Length = 590
Score = 127 bits (319), Expect = 7e-29
Identities = 99/325 (30%), Positives = 147/325 (44%), Gaps = 31/325 (9%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-------ESELNEHMLEIDLLKNL 62
+ L V+GRG +G V + R N+ AIK ++ D ES L+E + ++ +
Sbjct: 263 FRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRI-FEVANAM 321
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHE 122
RH +V Q + ++EY A G L + LE V Y + GLQYLHE
Sbjct: 322 RHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHE 381
Query: 123 QGVIHRDIKAANLLLTEEGIVKLADFGVSTR---INRMAMTYAGSPNWMAPEVMTGQGAS 179
+I+RD+K NLLL EG VK+ADFG+ T+ G+P ++APEV+T +
Sbjct: 382 NKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYT 441
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKN 239
D W LG + E+L G PF E +IVN+E P LS E + R +KN
Sbjct: 442 RAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKN 501
Query: 240 MFKRATAQELLAH-----------IW----LKKIQKPKSKINLAEYIEKDGKWDVDFVLD 284
+R + E A +W L+K++ P + ++E +D +F
Sbjct: 502 PERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPP--FVPTINHLEDVSNFDEEFT-S 558
Query: 285 SNTDMTP--SPTKSPIQEDLAPADF 307
+TP P +E L DF
Sbjct: 559 EKAQLTPPKEPRHLTEEEQLLFQDF 583
>7303914 [T] KOG0694 Serine/threonine protein kinase
Length = 1284
Score = 127 bits (319), Expect = 7e-29
Identities = 99/325 (30%), Positives = 147/325 (44%), Gaps = 31/325 (9%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-------ESELNEHMLEIDLLKNL 62
+ L V+GRG +G V + R N+ AIK ++ D ES L+E + ++ +
Sbjct: 957 FRLLSVLGRGHFGKVILSQLRSNNQYYAIKALKKGDIIARDEVESLLSEKRI-FEVANAM 1015
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHE 122
RH +V Q + ++EY A G L + LE V Y + GLQYLHE
Sbjct: 1016 RHPFLVNLYSCFQTEQHVCFVMEYAAGGDLMMHIHTDVFLEPRAVFYAACVVLGLQYLHE 1075
Query: 123 QGVIHRDIKAANLLLTEEGIVKLADFGVSTR---INRMAMTYAGSPNWMAPEVMTGQGAS 179
+I+RD+K NLLL EG VK+ADFG+ T+ G+P ++APEV+T +
Sbjct: 1076 NKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTGTFCGTPEFLAPEVLTETSYT 1135
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKN 239
D W LG + E+L G PF E +IVN+E P LS E + R +KN
Sbjct: 1136 RAVDWWGLGVLIFEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSLEAIAVMRRLLRKN 1195
Query: 240 MFKRATAQELLAH-----------IW----LKKIQKPKSKINLAEYIEKDGKWDVDFVLD 284
+R + E A +W L+K++ P + ++E +D +F
Sbjct: 1196 PERRLGSSERDAEDVKKQAFFRSIVWDDLLLRKVKPP--FVPTINHLEDVSNFDEEFT-S 1252
Query: 285 SNTDMTP--SPTKSPIQEDLAPADF 307
+TP P +E L DF
Sbjct: 1253 EKAQLTPPKEPRHLTEEEQLLFQDF 1277
>Hs5453974 [T] KOG0694 Serine/threonine protein kinase
Length = 984
Score = 127 bits (318), Expect = 9e-29
Identities = 81/243 (33%), Positives = 119/243 (48%), Gaps = 9/243 (3%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFED---ESELNEHMLE---IDLLKNLRHQNIV 68
V+GRG +G V A + TN+ AIK ++ D E++ M E + + ++RH +V
Sbjct: 662 VLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVRHPFLV 721
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
Q + ++EY A G L + E V Y + GLQYLHE +++R
Sbjct: 722 NLFACFQTKEHVCFVMEYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYR 781
Query: 129 DIKAANLLLTEEGIVKLADFGVSTR---INRMAMTYAGSPNWMAPEVMTGQGASTVSDIW 185
D+K NLLL EG VK+ADFG+ T+ G+P ++APEV+T + D W
Sbjct: 782 DLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSYTRAVDWW 841
Query: 186 SLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRAT 245
LG + E+L G PF E +IVN+E P LS E + R ++N +R
Sbjct: 842 GLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLG 901
Query: 246 AQE 248
A E
Sbjct: 902 ASE 904
>7295426 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 490
Score = 127 bits (318), Expect = 9e-29
Identities = 79/240 (32%), Positives = 131/240 (53%), Gaps = 11/240 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVK---RGTNKPCAIKQIE----FEDESELNEHMLEIDLLKNL 62
+ LK+V+G+G YG V++ K R NK A+K ++ ++ + E ++L+ +
Sbjct: 77 FELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAV 136
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLH 121
+H IVE Q +LY+ILEY + G L + + G LED T Y+++ + L +LH
Sbjct: 137 KHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLH 196
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGV---STRINRMAMTYAGSPNWMAPEVMTGQGA 178
+ G+I+RD+K N+LL +G VKL DFG+ + + T+ G+ +MAPE++T G
Sbjct: 197 KLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGH 256
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
D WSLGA + ++LTG PPF + I+ + P L+ E +D + R ++
Sbjct: 257 GKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKR 316
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 126 bits (317), Expect = 1e-28
Identities = 72/259 (27%), Positives = 132/259 (50%), Gaps = 8/259 (3%)
Query: 4 SIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN---EHMLEIDLLK 60
S++ + L + +G+G +G VY R T CA+K +E E+ + N + E+++
Sbjct: 98 SLSLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQT 157
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQY 119
+L H N+ + G+ +Y+++EY G + +L+ HGP + +Y+ Q L Y
Sbjct: 158 SLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDY 217
Query: 120 LHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQ 176
+H++ +IHRDIK N+L+ ++KL DFG S IN T G+ ++++PE++ +
Sbjct: 218 MHKKNIIHRDIKPENILIGFNNVIKLTDFGWSI-INPPENRRKTVCGTIDYLSPEMVESR 276
Query: 177 GASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCF 236
D W+LG ELLTG PPF + ++ I + P +S + +D + +
Sbjct: 277 EYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALDIKMPSNISQDAQDLILKLL 336
Query: 237 QKNMFKRATAQELLAHIWL 255
+ + R ++ H W+
Sbjct: 337 KYDPKDRMRLGDVKMHPWI 355
>Hs4507273 [D] KOG0580 Serine/threonine protein kinase
Length = 275
Score = 126 bits (317), Expect = 1e-28
Identities = 79/252 (31%), Positives = 131/252 (51%), Gaps = 5/252 (1%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI-EFEDESELNEHML--EIDLLKNLRHQN 66
+ + + +G+G +G VY A + ++ A+K + + + E E EH L EI++ +L+H N
Sbjct: 9 FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 68
Query: 67 IVEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
I+ + A +Y+ILEY RG L +++ K L E T + + L Y H++ V
Sbjct: 69 ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEEVADALTYCHDKKV 128
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM-TYAGSPNWMAPEVMTGQGASTVSDI 184
IHRDIK NLLL G VK+ADFG S T G+ +++ PE++ G+ D+
Sbjct: 129 IHRDIKPENLLLGFRGEVKIADFGWSVHTPLPERKTMCGTLDYLPPEMIEGRTYDEKVDL 188
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRA 244
W +G ELL G PPF + + I+ + PL++ +D +SR + +R
Sbjct: 189 WCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERL 248
Query: 245 TAQELLAHIWLK 256
++L H W++
Sbjct: 249 PLAQILKHPWVQ 260
>At4g24400 [T] KOG0583 Serine/threonine protein kinase
Length = 445
Score = 126 bits (317), Expect = 1e-28
Identities = 89/291 (30%), Positives = 141/291 (47%), Gaps = 12/291 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED---ESELNEHMLEIDLLKNLRH 64
G Y L + IG G + V A T + A+K ++ +++ EI ++K +RH
Sbjct: 7 GKYELGRTIGEGTFAKVKFAQNTETGESVAMKIVDRSTIIKRKMVDQIKREISIMKLVRH 66
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
+V + ++YIILEY G L D I+++G L E + Y Q + G+ Y H +
Sbjct: 67 PCVVRLYEVLASRTKIYIILEYITGGELFDKIVRNGRLSESEARKYFHQLIDGVDYCHSK 126
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGAS- 179
GV HRD+K NLLL +G +K++DFG+S + + T G+PN++APEV++ +G +
Sbjct: 127 GVYHRDLKPENLLLDSQGNLKISDFGLSALPEQGVTILKTTCGTPNYVAPEVLSHKGYNG 186
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKN 239
V+DIWS G + L+ G PF + + I E+ P + K ++R N
Sbjct: 187 AVADIWSCGVILYVLMAGYLPFDEMDLPTLYSKIDKAEFSCPSYFALGAKSLINRILDPN 246
Query: 240 MFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMT 290
R T E+ W K P I+ E++ D DV D + T
Sbjct: 247 PETRITIAEIRKDEWFLKDYTPVQLIDY-EHVNLD---DVYAAFDDPEEQT 293
>At2g30360 [T] KOG0583 Serine/threonine protein kinase
Length = 435
Score = 126 bits (317), Expect = 1e-28
Identities = 82/264 (31%), Positives = 132/264 (49%), Gaps = 11/264 (4%)
Query: 2 DNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE----FEDESELNEHMLEID 57
+N G Y L +++G GA+ V+ A R T + A+K + + + N EI
Sbjct: 13 NNDALFGKYELGKLLGCGAFAKVFHARDRRTGQSVAVKILNKKKLLTNPALANNIKREIS 72
Query: 58 LLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYG 116
+++ L H NIV+ + +++ +E+ G L I KHG L ED + Y Q +
Sbjct: 73 IMRRLSHPNIVKLHEVMATKSKIFFAMEFVKGGELFNKISKHGRLSEDLSRRYFQQLISA 132
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPE 171
+ Y H +GV HRD+K NLL+ E G +K++DFG+S R + + T G+P ++APE
Sbjct: 133 VGYCHARGVYHRDLKPENLLIDENGNLKVSDFGLSALTDQIRPDGLLHTLCGTPAYVAPE 192
Query: 172 VMTGQGASTVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKD 230
+++ +G D+WS G + L+ G PF++ + I EY P +S + K
Sbjct: 193 ILSKKGYEGAKVDVWSCGIVLFVLVAGYLPFNDPNVMNMYKKIYKGEYRFPRWMSPDLKR 252
Query: 231 FLSRCFQKNMFKRATAQELLAHIW 254
F+SR N R T E+L W
Sbjct: 253 FVSRLLDINPETRITIDEILKDPW 276
>At1g30270 [T] KOG0583 Serine/threonine protein kinase
Length = 480
Score = 126 bits (317), Expect = 1e-28
Identities = 91/291 (31%), Positives = 139/291 (47%), Gaps = 21/291 (7%)
Query: 8 GTYALKQVIGRGAYGVVY--RAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLK 60
G Y L + +G G + V R V+ G N AIK I+ E L M+ EI +K
Sbjct: 29 GKYELGRTLGEGTFAKVKFARNVENGDN--VAIKVID--KEKVLKNKMIAQIKREISTMK 84
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQY 119
++H N++ + ++Y +LE+ G L D I +G L ED+ Y Q + + Y
Sbjct: 85 LIKHPNVIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 144
Query: 120 LHEQGVIHRDIKAANLLLTEEGIVKLADFGVST---RINRMAMTYAGSPNWMAPEVMTGQ 176
H +GV HRD+K NLLL G +K++DFG+S + + + T G+PN++APEV+ +
Sbjct: 145 CHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQEDGLLHTTCGTPNYVAPEVINNK 204
Query: 177 G-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRC 235
G +D+WS G + L+ G PF + S I E+ P SA K + R
Sbjct: 205 GYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKKLIKRI 264
Query: 236 FQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSN 286
N R T E++ + W KK K N ++ DVD + D +
Sbjct: 265 LDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLD-----DVDAIFDDS 310
>Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 596
Score = 125 bits (315), Expect = 2e-28
Identities = 86/291 (29%), Positives = 150/291 (50%), Gaps = 25/291 (8%)
Query: 13 KQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRG 72
K+ +G G +G V +++ T A K I+ + + +LEI+++ L H+N+++
Sbjct: 288 KEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYA 347
Query: 73 FIQKAHELYIILEYCARGSL--RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDI 130
I+ HE+ + +EY G L R + + L E DT+ +V Q G+ ++H+ V+H D+
Sbjct: 348 AIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDL 407
Query: 131 KAANLLL--TEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQGASTVSDIW 185
K N+L T +VK+ DFG++ R N ++ + + G+P +++PEV+ S +D+W
Sbjct: 408 KPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNF-GTPEFLSPEVVNYDQISDKTDMW 466
Query: 186 SLGATVVELLTGNPPF------HNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKN 239
S+G LL+G PF L N + +EE +S E KDF+S K+
Sbjct: 467 SMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEETFE--AVSDEAKDFVSNLIVKD 524
Query: 240 MFKRATAQELLAHIWLKKI--------QKPKSKINLAEYIEKDGKWDVDFV 282
R A + LAH WL + ++ KS+I L +Y+ K +W +F+
Sbjct: 525 QRARMNAAQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMK-RRWKKNFI 574
>CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 648
Score = 125 bits (315), Expect = 2e-28
Identities = 77/249 (30%), Positives = 125/249 (49%), Gaps = 7/249 (2%)
Query: 8 GTYALK-QVIGRGAYGVVYRAVKRGTNKPCAIKQIE---FEDESELNEHMLEIDLLKNLR 63
GTY K + +G+G + Y R T + A K + + + ++ E+ + + L
Sbjct: 35 GTYYEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELG 94
Query: 64 HQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVT-QTLYGLQYLHE 122
H NIV+ F + +YI LE CAR SL ++ K + + Y T Q + G+ YLH+
Sbjct: 95 HINIVKLFNFFEDNLNVYITLELCARRSLMELHKRRKAVTEPEARYFTHQIVDGVLYLHD 154
Query: 123 QGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN--RMAMTYAGSPNWMAPEVMTGQGAST 180
+IHRD+K NL L ++ +VK+ DFG++T +N T G+PN++APEV+ G S
Sbjct: 155 LNIIHRDMKLGNLFLNDDLVVKIGDFGLATTVNGDERKKTLCGTPNYIAPEVLNKAGHSF 214
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
DIW++G + LL G PPF + E I + Y P + + +
Sbjct: 215 EVDIWAVGCILYILLFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEP 274
Query: 241 FKRATAQEL 249
+R TA+++
Sbjct: 275 TRRPTAKQV 283
>At5g45820 [T] KOG0583 Serine/threonine protein kinase
Length = 439
Score = 125 bits (315), Expect = 2e-28
Identities = 82/267 (30%), Positives = 133/267 (49%), Gaps = 13/267 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESE---LNEHMLEIDLLKNLRHQN 66
Y L +++G+G + VY A T + AIK I+ + ++ +++ EI +++ +RH +
Sbjct: 12 YELGRLLGQGTFAKVYHARNIKTGESVAIKVIDKQKVAKVGLIDQIKREISVMRLVRHPH 71
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
+V + ++Y +EY G L D + G L E+ Y Q + + Y H +GV
Sbjct: 72 VVFLHEVMASKTKIYFAMEYVKGGELFDKVSKGKLKENIARKYFQQLIGAIDYCHSRGVY 131
Query: 127 HRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTGQG-AST 180
HRD+K NLLL E G +K++DFG+S + + + T G+P ++APEV+ +G
Sbjct: 132 HRDLKPENLLLDENGDLKISDFGLSALRESKQQDGLLHTTCGTPAYVAPEVIGKKGYDGA 191
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
+D+WS G + LL G PFH I E+ P E K LSR N
Sbjct: 192 KADVWSCGVVLYVLLAGFLPFHEQNLVEMYRKITKGEFKCPNWFPPEVKKLLSRILDPNP 251
Query: 241 FKRATAQELLAHIW----LKKIQKPKS 263
R ++++ + W KKI+ PKS
Sbjct: 252 NSRIKIEKIMENSWFQKGFKKIETPKS 278
>YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 821
Score = 125 bits (314), Expect = 3e-28
Identities = 79/268 (29%), Positives = 138/268 (51%), Gaps = 23/268 (8%)
Query: 12 LKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDE-SELNEHMLEIDLLKNLRHQNIVEY 70
+ +V+G+GA+ V +A++R T K A+K I ++ E+++L+ L H IV
Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRL 259
Query: 71 RGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRD 129
+GF + Y+++E+ + G L D + HG + ED Q L ++Y+H G+ HRD
Sbjct: 260 KGFYEDTESYYMVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRD 319
Query: 130 IKAANLLLTEEG--IVKLADFGVS-TRINRMAM-TYAGSPNWMAPEVMTGQGA------- 178
+K N+L+ ++ +VK+ DFG++ + N M T+ G+ ++APEV+ G+
Sbjct: 320 LKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEY 379
Query: 179 ------STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEY----IPPLTLSAEC 228
S++ D+WS+G V +LTG+ PF + I Y + +S E
Sbjct: 380 EERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEA 439
Query: 229 KDFLSRCFQKNMFKRATAQELLAHIWLK 256
+DF+ Q + R+TA + L H W+K
Sbjct: 440 RDFIDSLLQVDPNNRSTAAKALNHPWIK 467
>Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 525
Score = 125 bits (314), Expect = 3e-28
Identities = 93/326 (28%), Positives = 160/326 (48%), Gaps = 25/326 (7%)
Query: 10 YALKQVIGRGAYGVVYRAVK---RGTNKPCAIKQIE----FEDESELNEHMLEIDLLKNL 62
+ L +V+G+G YG V++ K T K A+K ++ + + E ++L+ +
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEV 150
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLH 121
+H IV+ Q +LY+ILEY + G L + + G +ED Y+ + L +LH
Sbjct: 151 KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH 210
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGV---STRINRMAMTYAGSPNWMAPEVMTGQGA 178
++G+I+RD+K N++L +G VKL DFG+ S + T+ G+ +MAPE++ G
Sbjct: 211 QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGH 270
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
+ D WSLGA + ++LTG PPF + I+ + P L+ E +D L + ++
Sbjct: 271 NRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKR 330
Query: 239 NMFKR-----ATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMTPSP 293
N R A E+ AH + + IN E + + + +L S D++
Sbjct: 331 NAASRLGAGPGDAGEVQAHPFFR-------HINWEELLARKVEPPFKPLLQSEEDVSQFD 383
Query: 294 TKSPIQEDLAPADFRTL--SVDQLFI 317
+K Q + D TL S +Q+F+
Sbjct: 384 SKFTRQTPVDSPDDSTLSESANQVFL 409
>At2g25880 [D] KOG0580 Serine/threonine protein kinase
Length = 282
Score = 125 bits (314), Expect = 3e-28
Identities = 81/252 (32%), Positives = 125/252 (49%), Gaps = 6/252 (2%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQI-EFEDESELNEHML--EIDLLKNLRHQNIVEYRG 72
+GRG +G VY A ++ ++ A+K + + + + EH L E+++ +LRH NI+ G
Sbjct: 25 LGRGKFGHVYLAREKRSDHIVALKVLFKAQLQQSQVEHQLRREVEIQSHLRHPNILRLYG 84
Query: 73 FIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIK 131
+ +Y+ILEY RG L +++ K E YV L Y H + VIHRDIK
Sbjct: 85 YFYDQKRVYLILEYAVRGELYKELQKCKYFSERRAATYVASLARALIYCHGKHVIHRDIK 144
Query: 132 AANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATV 191
NLL+ +G +K+ADFG S T G+ +++ PE++ DIWSLG
Sbjct: 145 PENLLIGAQGELKIADFGWSVHTFNRRRTMCGTLDYLPPEMVESVEHDASVDIWSLGILC 204
Query: 192 VELLTGNPPFHNLVNESACYAIVNEE--YIPPLTLSAECKDFLSRCFQKNMFKRATAQEL 249
E L G PPF + IV + + P +S+ KD +S+ K +R +L
Sbjct: 205 YEFLYGVPPFEAREHSETYKRIVQVDLKFPPKPIVSSSAKDLISQMLVKESTQRLALHKL 264
Query: 250 LAHIWLKKIQKP 261
L H W+ + P
Sbjct: 265 LEHPWIVQNADP 276
>7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 835
Score = 125 bits (314), Expect = 3e-28
Identities = 92/320 (28%), Positives = 151/320 (46%), Gaps = 36/320 (11%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI----EFEDESELNEHMLEIDL 58
N + Y+ K ++G GA+ VVY+ R + P AIK I + + ++ L + + +
Sbjct: 2 NIVGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQLKTQNLLGKEIKILKE 61
Query: 59 LKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVN-YVTQTLYGL 117
L L H+N+V + + +++EYC G L D L L +DTV ++ Q +
Sbjct: 62 LTELHHENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAM 121
Query: 118 QYLHEQGVIHRDIKAANLLLTEEG----------IVKLADFGVSTRINR--MAMTYAGSP 165
+ L+ +G++HRD+K N+LL+ +K+ADFG + +N MA T GSP
Sbjct: 122 KALYTKGIVHRDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSP 181
Query: 166 NWMAPEVMTGQGASTVSDIWSLGATVVELLTGNPPFH-NLVNESACYAIVNEEYIP--PL 222
+MAPEV+ + +D+WSLG V + LTG PF+ NE Y N P P
Sbjct: 182 MYMAPEVIMSLQYDSKADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPS 241
Query: 223 TLSAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFV 282
+S + +D L ++N R + + H +L Q K+ ++ + G
Sbjct: 242 GVSPDLRDLLLCLLRRNSKDRISYESFFVHRFL---QGKKAAVSPVDMPPLGG------- 291
Query: 283 LDSNTDMTPSPTKSPIQEDL 302
P+ KSP+Q+ L
Sbjct: 292 ------TPPAKAKSPLQQQL 305
>Hs4502557 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 473
Score = 125 bits (313), Expect = 3e-28
Identities = 82/257 (31%), Positives = 133/257 (50%), Gaps = 13/257 (5%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
+ ++ +GRGA +VYR ++GT KP A+K ++ + ++ EI +L L H NI++
Sbjct: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVR--TEIGVLLRLSHPNIIK 103
Query: 70 YRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
+ + E+ ++LE G L D I++ G E D + V Q L + YLHE G++HR
Sbjct: 104 LKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHR 163
Query: 129 DIKAANLLL---TEEGIVKLADFGVSTRINRMAM--TYAGSPNWMAPEVMTGQGASTVSD 183
D+K NLL + +K+ADFG+S + + T G+P + APE++ G D
Sbjct: 164 DLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVD 223
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACY-AIVNEEY--IPPL--TLSAECKDFLSRCFQK 238
+WS+G LL G PF++ + + I+N EY I P +S KD + +
Sbjct: 224 MWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVL 283
Query: 239 NMFKRATAQELLAHIWL 255
+ KR T + L H W+
Sbjct: 284 DPKKRLTTFQALQHPWV 300
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 125 bits (313), Expect = 3e-28
Identities = 87/277 (31%), Positives = 140/277 (50%), Gaps = 17/277 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDE-SELNEHMLEIDLLKNLRHQNIV 68
Y + ++IG G++G +N+ A+K+I S E LL ++H NIV
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIV 63
Query: 69 EYRGFIQKAHELYIILEYCARGSLRDILKH--GPLLEDDTV-NYVTQTLYGLQYLHEQGV 125
++ + LYI++EYC G L +K G L +D + N+ TQ G+ ++H++ V
Sbjct: 64 AFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRV 123
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGASTVS 182
+HRDIK+ N+ LT+ G VKL DFG + ++ A TY G+P ++ PE+ + S
Sbjct: 124 LHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKS 183
Query: 183 DIWSLGATVVELLTGNPPFH-----NLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQ 237
DIWSLG + EL T PF NL+ + C ++ P S E + + + F+
Sbjct: 184 DIWSLGCILYELCTLKHPFQANSWKNLILK-VCQGCISP---LPSHYSYELQFLVKQMFK 239
Query: 238 KNMFKRATAQELLAH-IWLKKIQKPKSKINLAEYIEK 273
+N R +A LL+ I + +QK + EY E+
Sbjct: 240 RNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEE 276
>HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 124 bits (312), Expect = 4e-28
Identities = 69/201 (34%), Positives = 107/201 (52%), Gaps = 4/201 (1%)
Query: 54 LEIDLLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLL-EDDTVNYVTQ 112
+EI + ++L HQ++V + GF + ++++LE C R SL + K L E + Y+ Q
Sbjct: 100 MEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLEPHKRRKALTEPEARYYLRQ 159
Query: 113 TLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMA 169
+ G QYLH VIHRD+K NL L E+ VK+ DFG++T++ T G+PN++A
Sbjct: 160 IVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIA 219
Query: 170 PEVMTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECK 229
PEV++ + S D+WS+G + LL G PPF + I EY P ++
Sbjct: 220 PEVLSKKEHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAA 279
Query: 230 DFLSRCFQKNMFKRATAQELL 250
+ + Q + R T ELL
Sbjct: 280 SLIQKMLQTDPTARPTINELL 300
>Hs4759178 [D] KOG0580 Serine/threonine protein kinase
Length = 344
Score = 124 bits (312), Expect = 4e-28
Identities = 77/252 (30%), Positives = 132/252 (51%), Gaps = 5/252 (1%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI-EFEDESELNEHML--EIDLLKNLRHQN 66
+ + + +G+G +G VY A ++ ++ A+K + + + E E EH L EI++ +L H N
Sbjct: 77 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPN 136
Query: 67 IVEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
I+ + +Y+ILEY RG L +++ K E T + + L Y H + V
Sbjct: 137 ILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKV 196
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRINRMAM-TYAGSPNWMAPEVMTGQGASTVSDI 184
IHRDIK NLLL +G +K+ADFG S + T G+ +++ PE++ G+ + D+
Sbjct: 197 IHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDL 256
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRA 244
W +G ELL GNPPF + + IV + P ++ +D +S+ + N +R
Sbjct: 257 WCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLLRHNPSERL 316
Query: 245 TAQELLAHIWLK 256
++ AH W++
Sbjct: 317 PLAQVSAHPWVR 328
>CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 856
Score = 124 bits (312), Expect = 4e-28
Identities = 86/282 (30%), Positives = 143/282 (50%), Gaps = 23/282 (8%)
Query: 10 YALKQVIGRGAYGVVYRA--VKRGTNKPCAIKQIEFEDESELNEHML-EIDLLK---NLR 63
Y+ + ++G GA+ +VYR V R T+ P AIK I ++ S+ + EI +LK +L+
Sbjct: 9 YSKRDLLGHGAFAIVYRGRYVDR-TDVPVAIKAIAKKNISKSKNLLTKEIKILKELSSLK 67
Query: 64 HQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTV-NYVTQTLYGLQYLHE 122
H+N+V + +Y+++E+C G L D L+ L +DT+ ++V Q + L+ +++
Sbjct: 68 HENLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINK 127
Query: 123 QGVIHRDIKAANLLLTEEG----------IVKLADFGVSTRINR--MAMTYAGSPNWMAP 170
+G++HRD+K N+LL ++KLADFG + +N MA T GSP +MAP
Sbjct: 128 KGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAP 187
Query: 171 EVMTGQGASTVSDIWSLGATVVELLTGNPPF-HNLVNESACYAIVNEEYIP--PLTLSAE 227
EV+ +D+WS+G + + LTG PF + Y E P P S
Sbjct: 188 EVIMSMQYDAKADLWSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCSPN 247
Query: 228 CKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAE 269
+D L R ++N R + ++ H +L P + E
Sbjct: 248 LRDLLLRLLKRNAKDRISFEDFFNHPFLTSPLLPSPSKRILE 289
>At3g01090 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 124 bits (311), Expect = 6e-28
Identities = 85/254 (33%), Positives = 127/254 (49%), Gaps = 7/254 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHML-EIDLLKNLRHQN 66
Y L + +G G++G V A T AIK + E+ E + EI +L+ H +
Sbjct: 19 YKLGRTLGIGSFGRVKIAEHALTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPH 78
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
I+ I+ ++Y+++EY G L D I++ G L ED+ N+ Q + G++Y H V
Sbjct: 79 IIRLYEVIETPTDIYLVMEYVNSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMV 138
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVMTGQ-GASTVS 182
+HRD+K NLLL + VK+ADFG+S R T GSPN+ APEV++G+ A
Sbjct: 139 VHRDLKPENLLLDSKCNVKIADFGLSNIMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEV 198
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFK 242
D+WS G + LL G PF + + I Y P LS +D + R + K
Sbjct: 199 DVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSPGARDLIPRMLVVDPMK 258
Query: 243 RATAQELLAHIWLK 256
R T E+ H W +
Sbjct: 259 RVTIPEIRQHPWFQ 272
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 124 bits (311), Expect = 6e-28
Identities = 84/262 (32%), Positives = 126/262 (48%), Gaps = 24/262 (9%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEF------EDESELNEHMLEIDLLKNLRHQNI 67
Q IG GA+ Y+A GT A+KQ+ + E E + EI ++ +L H NI
Sbjct: 24 QQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNI 83
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
+ G + + +E+ A GS+ +L K+G E +NY Q L GL YLHE +I
Sbjct: 84 IRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQII 143
Query: 127 HRDIKAANLLLTEEG-IVKLADFGVSTRI-------NRMAMTYAGSPNWMAPEVMTGQGA 178
HRD+K ANLL+ G +++ADFG + R+ G+ +MAPEV+ GQ
Sbjct: 144 HRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQY 203
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--------PLTLSAECKD 230
D+WS+G ++E+ PP+ N S A++ + I P LS +D
Sbjct: 204 GRSCDVWSVGCAIIEMACAKPPW-NAEKHSNHLALIFKVIIASATTAPSIPSHLSPGLRD 262
Query: 231 FLSRCFQKNMFKRATAQELLAH 252
RC + R ++ELL H
Sbjct: 263 VALRCLELQPQDRPPSRELLKH 284
>Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 424
Score = 124 bits (310), Expect = 7e-28
Identities = 82/277 (29%), Positives = 133/277 (47%), Gaps = 12/277 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y +K +IGRG++ V R R T +P AIK IE + E+ +L+ +RH NI++
Sbjct: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQ 157
Query: 70 YRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHR 128
+ +Y+++E G L D I+ G E D + L G++YLH G+ HR
Sbjct: 158 LVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHR 217
Query: 129 DIKAANLLLTEEGI---VKLADFGVSTRINR----MAMTYAGSPNWMAPEVMTGQGASTV 181
D+K NLL G + + DFG+++ + + T G+P ++APEV+ + +
Sbjct: 218 DLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNS 277
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYI----PPLTLSAECKDFLSRCFQ 237
D+W+LG LL+G PF + I+ +Y P ++S KDF+ R
Sbjct: 278 VDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLT 337
Query: 238 KNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKD 274
+ R TA + L H W+ + S NL I ++
Sbjct: 338 VDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQN 374
>CE28643 [T] KOG0583 Serine/threonine protein kinase
Length = 564
Score = 124 bits (310), Expect = 7e-28
Identities = 83/257 (32%), Positives = 128/257 (49%), Gaps = 7/257 (2%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN---EHMLEIDLLKNLRH 64
G Y LK+ +G G +G V + T A+K + + L+ + EI L RH
Sbjct: 23 GHYILKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRH 82
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
+I+ I ++++I+E+ + G L D I+KHG L + + Q + G+ Y H
Sbjct: 83 PHIIRLYQVISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRH 142
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQ-GAST 180
V+HRD+K NLLL E+ VK+ADFG+S + T GSPN+ APEV++G+ A
Sbjct: 143 MVVHRDLKPENLLLDEQNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGP 202
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
D+WS G + LL G PF + S I + + P L + L +
Sbjct: 203 EVDVWSCGVILYALLCGTLPFDDEHVPSLFRKIKSGVFPTPDFLERPIVNLLHHMLCVDP 262
Query: 241 FKRATAQELLAHIWLKK 257
KRAT ++++AH W +K
Sbjct: 263 MKRATIKDVIAHEWFQK 279
>CE07458 [T] KOG0583 Serine/threonine protein kinase
Length = 562
Score = 124 bits (310), Expect = 7e-28
Identities = 83/257 (32%), Positives = 128/257 (49%), Gaps = 7/257 (2%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN---EHMLEIDLLKNLRH 64
G Y LK+ +G G +G V + T A+K + + L+ + EI L RH
Sbjct: 23 GHYILKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQNLSLFRH 82
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
+I+ I ++++I+E+ + G L D I+KHG L + + Q + G+ Y H
Sbjct: 83 PHIIRLYQVISTPSDIFMIMEHVSGGELFDYIVKHGRLKTAEARRFFQQIISGVDYCHRH 142
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQ-GAST 180
V+HRD+K NLLL E+ VK+ADFG+S + T GSPN+ APEV++G+ A
Sbjct: 143 MVVHRDLKPENLLLDEQNNVKIADFGLSNIMTDGDFLRTSCGSPNYAAPEVISGKLYAGP 202
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
D+WS G + LL G PF + S I + + P L + L +
Sbjct: 203 EVDVWSCGVILYALLCGTLPFDDEHVPSLFRKIKSGVFPTPDFLERPIVNLLHHMLCVDP 262
Query: 241 FKRATAQELLAHIWLKK 257
KRAT ++++AH W +K
Sbjct: 263 MKRATIKDVIAHEWFQK 279
>At5g45810 [T] KOG0583 Serine/threonine protein kinase
Length = 483
Score = 124 bits (310), Expect = 7e-28
Identities = 87/277 (31%), Positives = 139/277 (49%), Gaps = 16/277 (5%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED--ESELNEHML-EIDLLKNLRH 64
G Y + +++G G + VY A + + AIK I+ E +S L H+ EI +L+ +RH
Sbjct: 26 GKYEMGRLLGHGTFAKVYLARNAQSGESVAIKVIDKEKVLKSGLIAHIKREISILRRVRH 85
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV+ + ++Y ++EY G L + + G L E+ Y Q + + + H +G
Sbjct: 86 PNIVQLFEVMATKSKIYFVMEYVKGGELFNKVAKGRLKEEMARKYFQQLISAVSFCHFRG 145
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTGQGAS 179
V HRD+K NLLL E G +K++DFG+S R + + T+ G+P ++APEV+ +G
Sbjct: 146 VYHRDLKPENLLLDENGNLKVSDFGLSAVSDQIRQDGLFHTFCGTPAYVAPEVLARKGYD 205
Query: 180 TVS-DIWSLGATVVELLTGNPPFHNLVNESACY-AIVNEEYIPPLTLSAECKDFLSRCFQ 237
DIWS G + L+ G PFH+ N A Y I ++ P E L R +
Sbjct: 206 GAKVDIWSCGVILFVLMAGFLPFHDR-NVMAMYKKIYRGDFRCPRWFPVEINRLLIRMLE 264
Query: 238 KNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKD 274
+R T +++ W KK K ++ Y+E D
Sbjct: 265 TKPERRFTMPDIMETSWFKKGFK-----HIKFYVEDD 296
>Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 357
Score = 123 bits (309), Expect = 1e-27
Identities = 80/260 (30%), Positives = 131/260 (49%), Gaps = 17/260 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE----DESELNEHMLEIDLLKNLRHQ 65
+ K+ +G GA+ V A ++ T K A+K I + ES + EI +L+ ++H+
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIEN---EIAVLRKIKHE 79
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV + + LY++++ + G L D I++ G E D + Q L + YLH G
Sbjct: 80 NIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMG 139
Query: 125 VIHRDIKAANLLL---TEEGIVKLADFGVSTRINR--MAMTYAGSPNWMAPEVMTGQGAS 179
++HRD+K NLL EE + ++DFG+S + + T G+P ++APEV+ + S
Sbjct: 140 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYS 199
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEY--IPPL--TLSAECKDFLSRC 235
D WS+G LL G PPF++ + I+ EY P +S KDF+
Sbjct: 200 KAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNL 259
Query: 236 FQKNMFKRATAQELLAHIWL 255
+K+ KR T ++ H W+
Sbjct: 260 MEKDPNKRYTCEQAARHPWI 279
>Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 123 bits (309), Expect = 1e-27
Identities = 84/257 (32%), Positives = 130/257 (49%), Gaps = 11/257 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHMLEIDLLKNLRHQNIV 68
Y + V+G GA+ V A + T K AIK I E E + EI +L ++H NIV
Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79
Query: 69 EYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIH 127
+ LY+I++ + G L D I++ G E D + Q L ++YLH+ G++H
Sbjct: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVH 139
Query: 128 RDIKAANLL---LTEEGIVKLADFGVSTRIN--RMAMTYAGSPNWMAPEVMTGQGASTVS 182
RD+K NLL L E+ + ++DFG+S + + T G+P ++APEV+ + S
Sbjct: 140 RDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAV 199
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEY--IPPL--TLSAECKDFLSRCFQK 238
D WS+G LL G PPF++ + I+ EY P +S KDF+ +K
Sbjct: 200 DCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEK 259
Query: 239 NMFKRATAQELLAHIWL 255
+ KR T ++ L H W+
Sbjct: 260 DPEKRFTCEQALQHPWI 276
>ECU07g0360 [D] KOG0580 Serine/threonine protein kinase
Length = 272
Score = 123 bits (309), Expect = 1e-27
Identities = 81/256 (31%), Positives = 127/256 (48%), Gaps = 8/256 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI---EFEDESELNEHMLEIDLLKNLRHQN 66
+ + +++GRG +G V+ A +R A+K I E + + EI++ NL+H N
Sbjct: 10 FEIGRLLGRGKFGQVWLAREREKGFIVALKIIPIKEIQTVETARQIRREIEIHSNLKHPN 69
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDIL--KHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
I+ G +Y+ILEY +G L + G E +T Y+ Q + L Y+ E
Sbjct: 70 ILRMYGHFHDKDNIYLILEYAGKGEFFKFLSDRGGKFGEKETSLYIRQVMLALTYMKECN 129
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVST-RINRMAMTYAGSPNWMAPEVMTGQGASTVSD 183
VIHRDIK NLLL + +K+ADFG + ++ MT+ G+ ++APE++ + D
Sbjct: 130 VIHRDIKPENLLLGSDNQLKIADFGWAVYNADKRRMTFCGTMEYLAPEMVNNDIHDSGID 189
Query: 184 IWSLGATVVELLTGNPPFHNL-VNESACYAIVNE-EYIPPLTLSAECKDFLSRCFQKNMF 241
+W LG E L G PF + N Y +N +Y P T+S+ DF+SR +
Sbjct: 190 LWCLGILTYEFLMGKTPFESKNRNMREAYKKINSLKYTIPETISSNASDFISRLLVLSPG 249
Query: 242 KRATAQELLAHIWLKK 257
R E L H ++ K
Sbjct: 250 DRMELTEALNHPFIVK 265
>At4g30960 [T] KOG0583 Serine/threonine protein kinase
Length = 441
Score = 123 bits (309), Expect = 1e-27
Identities = 88/297 (29%), Positives = 147/297 (48%), Gaps = 14/297 (4%)
Query: 5 IAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESEL---NEHMLEIDLLKN 61
+ HG Y L +++G G + VY A T K A+K + E ++ ++ EI +++
Sbjct: 19 LLHGRYELGRLLGHGTFAKVYHARNIQTGKSVAMKVVGKEKVVKVGMVDQIKREISVMRM 78
Query: 62 LRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLH 121
++H NIVE + ++Y +E G L + G L ED Y Q + + + H
Sbjct: 79 VKHPNIVELHEVMASKSKIYFAMELVRGGELFAKVAKGRLREDVARVYFQQLISAVDFCH 138
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTGQ 176
+GV HRD+K NLLL EEG +K+ DFG+S + + + T G+P ++APEV+ +
Sbjct: 139 SRGVYHRDLKPENLLLDEEGNLKVTDFGLSAFTEHLKQDGLLHTTCGTPAYVAPEVILKK 198
Query: 177 G-ASTVSDIWSLGATVVELLTGNPPFH--NLVNESACYAIVNEEYIPPLTLSAECKDFLS 233
G +D+WS G + LL G PF NLVN I ++ P LS++ + ++
Sbjct: 199 GYDGAKADLWSCGVILFVLLAGYLPFQDDNLVN--MYRKIYRGDFKCPGWLSSDARRLVT 256
Query: 234 RCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMT 290
+ N R T ++++ W KK Q +S+ + DVDF++ + + T
Sbjct: 257 KLLDPNPNTRITIEKVMDSPWFKK-QATRSRNEPVAATITTTEEDVDFLVHKSKEET 312
>At5g07070 [T] KOG0583 Serine/threonine protein kinase
Length = 456
Score = 123 bits (308), Expect = 1e-27
Identities = 78/263 (29%), Positives = 127/263 (47%), Gaps = 9/263 (3%)
Query: 4 SIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN---EHMLEIDLLK 60
S+ Y + +++G+G + VY TN+ AIK I+ + + + EI +++
Sbjct: 6 SVLTERYEVGRLLGQGTFAKVYFGRSNHTNESVAIKMIDKDKVMRVGLSQQIKREISVMR 65
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYL 120
+H N+VE + +Y ++EYC G L + + G L ED Y Q + + +
Sbjct: 66 IAKHPNVVELYEVMATKSRIYFVIEYCKGGELFNKVAKGKLKEDVAWKYFYQLISAVDFC 125
Query: 121 HEQGVIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTG 175
H +GV HRDIK NLLL + +K++DFG+S R + + T G+P ++APEV+
Sbjct: 126 HSRGVYHRDIKPENLLLDDNDNLKVSDFGLSALADCKRQDGLLHTTCGTPAYVAPEVINR 185
Query: 176 QG-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSR 234
+G T +DIWS G + LL G PFH+ I ++ P + E K L +
Sbjct: 186 KGYEGTKADIWSCGVVLFVLLAGYLPFHDTNLMEMYRKIGKADFKCPSWFAPEVKRLLCK 245
Query: 235 CFQKNMFKRATAQELLAHIWLKK 257
N R T ++ W +K
Sbjct: 246 MLDPNHETRITIAKIKESSWFRK 268
>At2g31500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 582
Score = 123 bits (308), Expect = 1e-27
Identities = 87/283 (30%), Positives = 138/283 (48%), Gaps = 24/283 (8%)
Query: 7 HGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED---ESELNEHMLEIDLLKNL- 62
H Y L + +GRG +GV + ++ T + A K+I E E ++ + E+++++ L
Sbjct: 63 HLKYDLGKELGRGEFGVTHECIEISTRERFACKRISKEKLRTEIDVEDVRREVEIMRCLP 122
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLH 121
+H NIV ++ + +Y+++E C G L D I+ G E + L ++ H
Sbjct: 123 KHPNIVSFKEAFEDKDAVYLVMEICEGGELFDRIVSRGHYTERAAASVAKTILEVVKVCH 182
Query: 122 EQGVIHRDIKAANLLL---TEEGIVKLADFGVST------RINRMAMTYAGSPNWMAPEV 172
E GVIHRD+K N L TE +K DFG+S R N + GSP +MAPEV
Sbjct: 183 EHGVIHRDLKPENFLFSNGTETAQLKAIDFGLSIFFKPAQRFNEIV----GSPYYMAPEV 238
Query: 173 MTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNE----EYIPPLTLSAEC 228
+ + D+WS G + LL G PPF E +AIV E P +S E
Sbjct: 239 LRRNYGPEI-DVWSAGVILYILLCGVPPFWAETEEGIAHAIVRGNIDFERDPWPKVSHEA 297
Query: 229 KDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYI 271
K+ + N + R T QE+L H W++ ++ + +NL + +
Sbjct: 298 KELVKNMLDANPYSRLTVQEVLEHPWIRNAERAPN-VNLGDNV 339
>SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 460
Score = 122 bits (307), Expect = 2e-27
Identities = 85/267 (31%), Positives = 137/267 (50%), Gaps = 23/267 (8%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE-------FEDESELNEHMLEIDLLKNL 62
Y + + +G G + VV AV+ + K AIK I ++ EID+LK+L
Sbjct: 167 YEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSL 226
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
H +V+ + EL+I++EY G L D L +G + E D + Q L L +LH
Sbjct: 227 HHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLETLLHLH 286
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQ-- 176
+QGV HRDIK N+L+T + +K++DFG++ I+ T+ G+ ++APEV+ +
Sbjct: 287 KQGVTHRDIKPENILITNDFHLKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNV 346
Query: 177 ----GASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PL---TLSAE 227
G DIWSLG + +LT + PF + +++ C ++++ P PL +S E
Sbjct: 347 NLDGGYDDKVDIWSLGCVLYVMLTASIPFAS-SSQAKCIELISKGAYPIEPLLENEISEE 405
Query: 228 CKDFLSRCFQKNMFKRATAQELLAHIW 254
D ++R + N KR + E L H W
Sbjct: 406 GIDLINRMLEINPEKRISESEALQHPW 432
>Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 495
Score = 122 bits (307), Expect = 2e-27
Identities = 77/245 (31%), Positives = 132/245 (53%), Gaps = 11/245 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVK-RGTN--KPCAIKQIE----FEDESELNEHMLEIDLLKNL 62
+ L +V+G+G YG V++ K +GTN K A+K + + + E ++L+++
Sbjct: 80 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 139
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLH 121
+H IVE Q +LY+ILE + G L L + G LED Y+ + L +LH
Sbjct: 140 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 199
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGV---STRINRMAMTYAGSPNWMAPEVMTGQGA 178
QG+I+RD+K N++L+ +G +KL DFG+ S + T+ G+ +MAPE++ G
Sbjct: 200 SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGH 259
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQK 238
+ D WSLGA + ++LTG+PPF + I+ + P L+ + +D + + ++
Sbjct: 260 NRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKR 319
Query: 239 NMFKR 243
N +R
Sbjct: 320 NPSQR 324
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 122 bits (307), Expect = 2e-27
Identities = 80/249 (32%), Positives = 130/249 (52%), Gaps = 7/249 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEF--EDESELNEHMLEIDLLKNLRHQNI 67
Y + ++IG G++G VY+ ++ + + A+K I E EL EI++++ LRH NI
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNI 63
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILKH-GPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
V + E+ ++ +Y A G L IL+ G L ED Q + L YLH ++
Sbjct: 64 VHMLDSFETDKEVVVVTDY-AEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRIL 122
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMT-YAGSPNWMAPEVMTGQGASTVSD 183
HRD+K N+LL + G +KL DFG + + N M +T G+P +M+PE++ + +D
Sbjct: 123 HRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTAD 182
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKR 243
+WS+G + EL G PPF+ I+ + P T+S K+FL K+ +R
Sbjct: 183 LWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQR 242
Query: 244 ATAQELLAH 252
+ +LL H
Sbjct: 243 LSWPDLLYH 251
>7293496 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 805
Score = 122 bits (307), Expect = 2e-27
Identities = 72/248 (29%), Positives = 125/248 (50%), Gaps = 5/248 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDES--ELNEHMLEIDLLKNLRHQNI 67
YA+ ++G+G++G VY+A ++ +K AIK I + EL E D+ L+H ++
Sbjct: 4 YAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHV 63
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIH 127
+E + +L+++ E+ R + +G + E+ + L YLH ++H
Sbjct: 64 IEMIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRILH 123
Query: 128 RDIKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTVSDI 184
RD+K N+LL + KL DFG++ + + + G+P +MAPE++ Q +D+
Sbjct: 124 RDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADM 183
Query: 185 WSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRA 244
WSLG E + G PPF I +E+ P TL++EC+ FL +K+ R
Sbjct: 184 WSLGCIAYESMAGQPPFCASSILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRI 243
Query: 245 TAQELLAH 252
+ +LL H
Sbjct: 244 SWTQLLCH 251
>Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 122 bits (306), Expect = 2e-27
Identities = 85/266 (31%), Positives = 140/266 (51%), Gaps = 18/266 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN--EHML--EIDLLKNLRHQ 65
Y +VIG G + VV R T + A+K I D+S L E M+ EI ++++L H
Sbjct: 284 YETGRVIGDGNFAVVKECRHRETRQAYAMKII---DKSRLKGKEDMVDSEILIIQSLSHP 340
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV+ + E+Y+ILEY G L D I++ E D + L ++H++
Sbjct: 341 NIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKS 400
Query: 125 VIHRDIKAANLLLT----EEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMTGQGAST 180
++HRD+K NLL+ + +KLADFG++ + R T G+P ++APE+++ +G
Sbjct: 401 IVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGL 460
Query: 181 VSDIWSLGATVVELLTGNPPFHNLV-NESACYAIV---NEEYIPPL--TLSAECKDFLSR 234
D+W+ G + LL G PPF + ++ + I+ + E++PP +S KD +SR
Sbjct: 461 EVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSR 520
Query: 235 CFQKNMFKRATAQELLAHIWLKKIQK 260
+ KR TA ++L H W++ K
Sbjct: 521 LLVVDPKKRYTAHQVLQHPWIETAGK 546
>At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 594
Score = 122 bits (306), Expect = 2e-27
Identities = 89/268 (33%), Positives = 140/268 (52%), Gaps = 21/268 (7%)
Query: 8 GTYALKQVIGRGAYG-VVYRAVKRGT--NKPCAIKQI---EFEDESELNEHMLEIDLLKN 61
G Y L + +GRG +G + K+G N+ A+K I + + + E+ LLK
Sbjct: 141 GKYELGKEVGRGHFGHTCWAKAKKGKMKNQTVAVKIISKAKMTSTLSIEDVRREVKLLKA 200
Query: 62 LR-HQNIVEYRGFIQKAHELYIILEYCARGSLRD--ILKHGPLLEDDTVNYVTQTLYGLQ 118
L H+++V++ + A +++++E C G L D + + G E D + Q L
Sbjct: 201 LSGHRHMVKFYDVYEDADNVFVVMELCEGGELLDRILARGGRYPEVDAKRILVQILSATA 260
Query: 119 YLHEQGVIHRDIKAANLLLT---EEGIVKLADFGVST--RINRMAMTYAGSPNWMAPEVM 173
+ H QGV+HRD+K N L T E+ I+K+ DFG+S R ++ GS ++APEV+
Sbjct: 261 FFHLQGVVHRDLKPENFLFTSRNEDAILKVIDFGLSDFIRYDQRLNDVVGSAYYVAPEVL 320
Query: 174 TGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIV-----NEEYIPPLTLSAEC 228
+ ST +D+WS+G LL G+ PF+ ESA + V N E +P ++S
Sbjct: 321 H-RSYSTEADMWSIGVISYILLCGSRPFYGRT-ESAIFRCVLRANPNFEDMPWPSISPTA 378
Query: 229 KDFLSRCFQKNMFKRATAQELLAHIWLK 256
KDF+ R K+ KR TA + LAH WL+
Sbjct: 379 KDFVKRLLNKDHRKRMTAAQALAHPWLR 406
>CE09360 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 2783
Score = 122 bits (305), Expect = 3e-27
Identities = 75/265 (28%), Positives = 139/265 (52%), Gaps = 10/265 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVE 69
Y + + +G+GAYG VYRA ++ T K A K ++ + + EI ++ L H+ ++
Sbjct: 195 YIIHEELGKGAYGTVYRATEKATGKTWAAKMVQVRPGVKKENVIHEISMMNQLHHEKLLN 254
Query: 70 YRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTV-NYVTQTLYGLQYLHEQGVIH 127
+E+++I E+ + G L IL+ L+ ++ V +Y+ Q L G+ ++H+ ++H
Sbjct: 255 LHEAFDMGNEMWLIEEFVSGGELFEKILEDDSLMSEEEVRDYMHQILLGVSHMHKNQIVH 314
Query: 128 RDIKAANLLLTEEGI--VKLADFGVSTRIN--RMAMTYAGSPNWMAPEVMTGQGASTVSD 183
D+K N+LL + +K+ DFG++ +++ + G+P + APEV+ Q +D
Sbjct: 315 LDLKPENILLKAKNSNELKIIDFGLARKLDPKKSVKLLFGTPEFCAPEVVNYQPVGLSTD 374
Query: 184 IWSLGATVVELLTGNPPFHNLVNES--ACYAIVNEEYIPPL--TLSAECKDFLSRCFQKN 239
+W++G LL+G PF +E A + + ++ P +S KDF+ R K+
Sbjct: 375 MWTVGVISYVLLSGLSPFLGDSDEDTLANVSASDWDFDDPSWDDVSDLAKDFICRLMIKD 434
Query: 240 MFKRATAQELLAHIWLKKIQKPKSK 264
KR + Q+ L H W+ K+Q K
Sbjct: 435 KRKRMSVQDALRHPWITKMQPKLDK 459
>At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 488
Score = 122 bits (305), Expect = 3e-27
Identities = 98/381 (25%), Positives = 165/381 (42%), Gaps = 44/381 (11%)
Query: 2 DNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE---FEDESELNEHMLEIDL 58
+N +H + ++ G G+Y V RA K+ T A+K ++ E++ LE +
Sbjct: 34 ENFTSHD-FEFGKIYGVGSYSKVVRAKKKETGTVYALKIMDKKFITKENKTAYVKLERIV 92
Query: 59 LKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGL 117
L L H I++ Q LY+ LE C G L D I + G L ED+ Y + + L
Sbjct: 93 LDQLEHPGIIKLYFTFQDTSSLYMALESCEGGELFDQITRKGRLSEDEARFYTAEVVDAL 152
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFG-------------VSTRINRMAMTYAGS 164
+Y+H G+IHRDIK NLLLT +G +K+ADFG + + A T+ G+
Sbjct: 153 EYIHSMGLIHRDIKPENLLLTSDGHIKIADFGSVKPMQDSQITVLPNAASDDKACTFVGT 212
Query: 165 PNWMAPEVMTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL 224
++ PEV+ A+ +D+W+LG T+ ++L+G PF + I+ + P
Sbjct: 213 AAYVPPEVLNSSPATFGNDLWALGCTLYQMLSGTSPFKDASEWLIFQRIIARDIKFPNHF 272
Query: 225 SAECKDFLSRCFQKNMFKRATA-------------------QELLAHIWLKKIQKPKSKI 265
S +D + R +R A + L + K P S+
Sbjct: 273 SEAARDLIDRLLDTEPSRRPGAGSEGYVALKRHPFFNGVDWKNLRSQTPPKLAPDPASQT 332
Query: 266 NLAEYIEKDGK-WDVDFVLDSNTDMTPSPTKSPIQEDLAPADFRTLSVD------QLFIE 318
E + G W++ + DS + P + + + R S+D Q F+E
Sbjct: 333 ASPERDDTHGSPWNLTHIGDSLATQNEGHSAPPTSSESSGSITRLASIDSFDSRWQQFLE 392
Query: 319 HSTDSIVVGLIKTLNELTAIK 339
+++ +K L ++T+ K
Sbjct: 393 PGESVLMISAVKKLQKITSKK 413
>At1g76040 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 534
Score = 122 bits (305), Expect = 3e-27
Identities = 84/273 (30%), Positives = 134/273 (48%), Gaps = 15/273 (5%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED---ESELNEHMLEIDLLKNLRHQ- 65
Y L + +GRG +G+ Y+ + + A K I ++ + E+ +L++L Q
Sbjct: 85 YDLHKELGRGQFGITYKCTDKSNGREYACKSISKRKLIRRKDIEDVRREVMILQHLTGQP 144
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIVE+RG + L++++E C+ G L D I+K G E + N Q + + H G
Sbjct: 145 NIVEFRGAYEDKDNLHLVMELCSGGELFDRIIKKGSYSEKEAANIFRQIVNVVHVCHFMG 204
Query: 125 VIHRDIKAANLLLT---EEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQGAS 179
V+HRD+K N LL E+ +K DFG+S I ++ GS ++APEV+
Sbjct: 205 VVHRDLKPENFLLVSNEEDSPIKATDFGLSVFIEEGKVYRDIVGSAYYVAPEVLHRNYGK 264
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAI----VNEEYIPPLTLSAECKDFLSRC 235
+ D+WS G + LL+G PPF ++ AI ++ E P T+S KD + +
Sbjct: 265 EI-DVWSAGVMLYILLSGVPPFWGETEKTIFEAILEGKLDLETSPWPTISESAKDLIRKM 323
Query: 236 FQKNMFKRATAQELLAHIWLKKIQKPKSKINLA 268
++ KR TA E L H W+ + IN A
Sbjct: 324 LIRDPKKRITAAEALEHPWMTDTKISDKPINSA 356
>7304358 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 493
Score = 122 bits (305), Expect = 3e-27
Identities = 82/279 (29%), Positives = 143/279 (50%), Gaps = 19/279 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEID--LLKNLRHQNI 67
Y +K+ +G+GA+ +V R V++ T A K I + + + LE + + + L H NI
Sbjct: 14 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 73
Query: 68 VEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
V IQ+ + Y++ + G L DI+ E D + + Q L + + H+ GV+
Sbjct: 74 VRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVV 133
Query: 127 HRDIKAANLLLTEEG---IVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGAST 180
HRD+K NLLL + VKLADFG++ + ++ +AG+P +++PEV+ +
Sbjct: 134 HRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGK 193
Query: 181 VSDIWSLGATVVELLTGNPPF-----HNLVNE--SACYAIVNEEYIPPLTLSAECKDFLS 233
DIW+ G + LL G PPF H L ++ + Y + E+ T++ E K+ ++
Sbjct: 194 SVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWD---TVTPEAKNLIN 250
Query: 234 RCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIE 272
+ N KR TA E L H W+ + ++ S ++ E ++
Sbjct: 251 QMLTVNPNKRITAAEALKHPWICQRERVASVVHRQETVD 289
>SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 121 bits (304), Expect = 4e-27
Identities = 90/275 (32%), Positives = 133/275 (47%), Gaps = 19/275 (6%)
Query: 5 IAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-EIDLLKNLR 63
+ +G +G G G V + RGT A+K + + L + +L E+ + ++
Sbjct: 74 VTNGGILYMNSLGEGVSGSVRKCRIRGTQMIFAMKTVLAAPNTALQKQLLRELKINRSCT 133
Query: 64 HQNIVEYRGFIQKAHE--LYIILEYCARGSLRDILKH-----GPLLEDDTVNYVTQTLYG 116
IV+Y G E L I +EYC GSL I K G E L G
Sbjct: 134 SPYIVKYYGACYNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSG 193
Query: 117 LQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTR-INRMAMTYAGSPNWMAPEVMTG 175
L YLH++ +IHRDIK +N+LLT +G VKL DFGVS +N +A T+ G+ +MAPE ++G
Sbjct: 194 LSYLHDRKIIHRDIKPSNILLTSKGQVKLCDFGVSGELVNSLAGTFTGTSYYMAPERISG 253
Query: 176 QGASTVSDIWSLGATVVELLTGNPPF------HNLVNESACYAIVNEEYI----PPLTLS 225
+ SDIWSLG T++E+ PF + E Y I + P + S
Sbjct: 254 GSYTISSDIWSLGLTLMEVALNRFPFPPEGSPPPMPIELLSYIINMPPPLLPQEPGIKWS 313
Query: 226 AECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQK 260
+ FL C K+ +R Q++L H W+K ++
Sbjct: 314 KSFQHFLCVCLDKDKTRRPGPQKMLTHPWVKAFER 348
>Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 454
Score = 121 bits (304), Expect = 4e-27
Identities = 79/270 (29%), Positives = 134/270 (49%), Gaps = 21/270 (7%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN------EHMLEIDLLKNLR 63
Y + + +G G + +V + ++GT K A K I+ S E E+++L+ +R
Sbjct: 13 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 72
Query: 64 HQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLHE 122
H NI+ + ++ +ILE + G L D L + L ED+ ++ Q L G+ YLH
Sbjct: 73 HPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHS 132
Query: 123 QGVIHRDIKAANLLLTEEGI----VKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQ 176
+ + H D+K N++L ++ + +KL DFG++ +I G+P ++APE++ +
Sbjct: 133 KRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYE 192
Query: 177 GASTVSDIWSLGATVVELLTGNPPF------HNLVNESACYAIVNEEYIPPLTLSAECKD 230
+D+WS+G LL+G PF L N SA +EEY S KD
Sbjct: 193 PLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFS--NTSELAKD 250
Query: 231 FLSRCFQKNMFKRATAQELLAHIWLKKIQK 260
F+ R K+ +R T + L H W+K I++
Sbjct: 251 FIRRLLVKDPKRRMTIAQSLEHSWIKAIRR 280
>At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 356
Score = 121 bits (304), Expect = 4e-27
Identities = 91/263 (34%), Positives = 141/263 (53%), Gaps = 18/263 (6%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHM---LEIDLLKNLRHQNIVEY 70
+VIG+G+ GVV + K A+K I+ + E+ + + L+I+ + +V Y
Sbjct: 74 KVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPHVVVCY 133
Query: 71 RGFIQKAHELYIILEYCARGSLRDILKH-GPLLEDDTVNYVTQTLYGLQYLH-EQGVIHR 128
F ++LEY RGSL D+++ +LE Q L GL YLH E+ VIHR
Sbjct: 134 HSFYHNG-AFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLHNERHVIHR 192
Query: 129 DIKAANLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIW 185
DIK +NLL+ +G VK++DFGVS + + M T+ G+ N+M+PE ++G SDIW
Sbjct: 193 DIKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTFVGTYNYMSPERISGSTYDYSSDIW 252
Query: 186 SLGATVVELLTGNPPF---HNLVNESACYAIVNE--EYIPPLT----LSAECKDFLSRCF 236
SLG +V+E G P+ + N + Y ++ E PP S E F+S C
Sbjct: 253 SLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIVENPPPTAPSDQFSPEFCSFVSACI 312
Query: 237 QKNMFKRATAQELLAHIWLKKIQ 259
QK+ RA++ +LL+H ++KK +
Sbjct: 313 QKDPPARASSLDLLSHPFIKKFE 335
>At1g05100 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 339
Score = 121 bits (304), Expect = 4e-27
Identities = 82/260 (31%), Positives = 133/260 (50%), Gaps = 21/260 (8%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGF 73
+ +GRG+ V A + + A+K EF L E +L +L ++ YRG
Sbjct: 7 KTLGRGSTATVSAATCHESGETLAVKSAEFHRSEFLQR---EAKILSSLNSPYVIGYRGC 63
Query: 74 I---------QKAHELYIILEYCARGSLRDIL-KHGPLLEDD-TVNYVTQTLYGLQYLHE 122
+A +++EY G+L D+ K+G +++ V Y Q L GL+Y+H
Sbjct: 64 EITREPFHNNGEATTYSLLMEYAPYGTLTDVATKNGGFIDEARVVKYTRQILLGLEYIHN 123
Query: 123 -QGVIHRDIKAANLLLTEEGIVKLADFGVSTRIN-RMAMTYAGSPNWMAPEVMTGQGAST 180
+G+ H DIK +N+L+ E G K+ADFG + + + G+P +MAPE G+
Sbjct: 124 SKGIAHCDIKGSNVLVGENGEAKIADFGCAKWVEPEITEPVRGTPAFMAPEAARGERQGK 183
Query: 181 VSDIWSLGATVVELLTGNPP-----FHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRC 235
SDIW++G TV+E++TG+ P F + V+ + E P +L+ + KDFL +C
Sbjct: 184 ESDIWAVGCTVIEMVTGSQPWIGADFTDPVSVLYRVGYLGELPELPCSLTEQAKDFLGKC 243
Query: 236 FQKNMFKRATAQELLAHIWL 255
+K +R TA +LL H +L
Sbjct: 244 LKKEATERWTASQLLNHPFL 263
>YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 515
Score = 121 bits (303), Expect = 5e-27
Identities = 98/289 (33%), Positives = 148/289 (50%), Gaps = 32/289 (11%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESE--LNEHMLEIDLLKNLR-HQNIVEYRG 72
IG G G V +A+ +K A K I E + +N+ + E+ ++KN++ H+NI+ + G
Sbjct: 197 IGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYG 256
Query: 73 FIQKAH---ELYIILEYCARGSLRDILK-HGPLLEDDTV-------NYVTQT------LY 115
H E+ I++EY GSL IL + ++ TV N +T + L
Sbjct: 257 AYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLN 316
Query: 116 GLQYLHEQ-GVIHRDIKAANLLLTEEGIVKLADFGVSTR-INRMAMTYAGSPNWMAPEVM 173
GL +L+ Q +IHRDIK +N+L+ +G +KL DFGVS + IN +A T+ G+ +M+PE +
Sbjct: 317 GLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERI 376
Query: 174 TGQGASTVSDIWSLGATVVELLTGNPPF--HNLVNE---SACYAIVNEEYIPPL----TL 224
G S D+WSLG ++EL+TG P HN + IVNE P L
Sbjct: 377 QGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEP-SPRLPKDRIY 435
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEK 273
S E DF++RC KN +R++ ELL H + K P + K
Sbjct: 436 SKEMTDFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDKFRHWCRK 484
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 121 bits (303), Expect = 5e-27
Identities = 76/271 (28%), Positives = 133/271 (49%), Gaps = 7/271 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDE--SELNEHMLE--IDLLKNLRHQ 65
+ + + +G+G +G VY A + + AIK + F+ + S EH LE I++ +L H
Sbjct: 30 FEIGRPLGKGKFGSVYLARTKTGHFHVAIKVL-FKSQLISGGVEHQLEREIEIQSHLNHP 88
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTV-NYVTQTLYGLQYLHEQG 124
NI++ + A ++Y++LEY G + L + T Y+ + L Y H +
Sbjct: 89 NIIKLYTYFWDAKKIYLVLEYAPGGEMYKQLTVSKRFSEPTAAKYMYEIADALSYCHRKN 148
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRI-NRMAMTYAGSPNWMAPEVMTGQGASTVSD 183
VIHRDIK NLL+ +G +K+ DFG S + T G+ +++ PE++ G S D
Sbjct: 149 VIHRDIKPENLLIGSQGELKIGDFGWSVHAPSNKRQTMCGTMDYLPPEMVNGADHSDAVD 208
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKR 243
+W++G E L G PPF + AI + P ++ +D + R + R
Sbjct: 209 LWAIGVLCYEFLVGKPPFEHEDQSKTYAAIKAARFTYPDSVKKGARDLIGRLLVVDPKAR 268
Query: 244 ATAQELLAHIWLKKIQKPKSKINLAEYIEKD 274
T +++ H W++ + + K + + IEK+
Sbjct: 269 CTLEQVKEHYWIQGMMEAKIRAEKQQKIEKE 299
>7290150 [T] KOG0583 Serine/threonine protein kinase
Length = 582
Score = 121 bits (303), Expect = 5e-27
Identities = 82/257 (31%), Positives = 127/257 (48%), Gaps = 7/257 (2%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN---EHMLEIDLLKNLRH 64
G Y L +G G +G V + T A+K + + L+ + EI LK RH
Sbjct: 26 GHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRH 85
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
+I++ I ++++I+EY + G L D I+KHG L E + Q + G+ Y H
Sbjct: 86 PHIIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGKLQEHQARRFFQQIISGVDYCHRH 145
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQ-GAST 180
++HRD+K NLLL VK+ADFG+S + T GSPN+ APEV++G+ A
Sbjct: 146 MIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGP 205
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
DIWS G + LL G PF + + I + + P L+ + + + + Q +
Sbjct: 206 EVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDP 265
Query: 241 FKRATAQELLAHIWLKK 257
KRA +E+ H W +K
Sbjct: 266 LKRANIEEIKKHEWFQK 282
>YFR014c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 446
Score = 120 bits (302), Expect = 6e-27
Identities = 80/263 (30%), Positives = 129/263 (48%), Gaps = 17/263 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE----DESELNEHMLEIDLLKNLRHQ 65
Y + +G G +GVV +A T + A+K + + ++ +L E+D+L+ L H
Sbjct: 37 YVFGKTLGAGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHP 96
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV ++ + + + YII + G L D ILK G E+D V + + L ++Y+H Q
Sbjct: 97 NIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQN 156
Query: 125 VIHRDIKAANLLL---TEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGA 178
++HRD+K NLL ++E + +ADFG++ R+ + AGS ++APEV+T G
Sbjct: 157 IVHRDLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGH 216
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL------TLSAECKDFL 232
DIWS+G LL G F + EY ++S + K F+
Sbjct: 217 GKPCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFI 276
Query: 233 SRCFQKNMFKRATAQELLAHIWL 255
+ + KR TA ELL W+
Sbjct: 277 LKALNLDPSKRPTAAELLEDPWI 299
>Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 628
Score = 120 bits (302), Expect = 6e-27
Identities = 75/253 (29%), Positives = 130/253 (50%), Gaps = 9/253 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI---EFEDESELNEHMLEIDLLKNLRHQN 66
Y + +G+G YG V +A + + + AIK I + +DE +L EI+++ +L H +
Sbjct: 53 YEFLETLGKGTYGKVKKA-RESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQGV 125
I+ + + ++ I++EY +RG L D I + L E + ++ Q + + Y H+ V
Sbjct: 112 IIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRV 171
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRIN--RMAMTYAGSPNWMAPEVMTGQG-ASTVS 182
+HRD+K N+LL G +K+ADFG+S + + T+ GSP + +PE++ G+
Sbjct: 172 VHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEV 231
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFK 242
D WSLG + L+ G PF ++ I N Y P S C + N +
Sbjct: 232 DSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDAC-GLIRWLLMVNPTR 290
Query: 243 RATAQELLAHIWL 255
RAT +++ +H W+
Sbjct: 291 RATLEDVASHWWV 303
>CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 632
Score = 120 bits (302), Expect = 6e-27
Identities = 70/229 (30%), Positives = 117/229 (50%), Gaps = 6/229 (2%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE---FEDESELNEHMLEIDLLKNLRHQN 66
Y + +G+G + Y + T + A K + + + ++ E+ + +NL+H+N
Sbjct: 36 YEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRN 95
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVT-QTLYGLQYLHEQGV 125
+V+ F + +YI LE C R SL ++ K + + Y T Q + G+ YLH +
Sbjct: 96 VVKLYHFFEDKSNVYITLELCPRRSLMELHKRRKAVTEPEARYFTYQIVEGVLYLHNLKI 155
Query: 126 IHRDIKAANLLLTEEGIVKLADFGVSTRINR--MAMTYAGSPNWMAPEVMTGQGASTVSD 183
+HRD+K NL L +E VK+ DFG++T + T G+PN++APEV+ G S D
Sbjct: 156 VHRDLKLGNLFLNDELQVKIGDFGLATTCDNDERKKTLCGTPNYIAPEVLNKIGHSFEVD 215
Query: 184 IWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFL 232
+W++G + LL G+PPF + E I N Y+ P + SA +
Sbjct: 216 LWAIGCILYILLFGHPPFESKSLEETYSRIKNNNYVIPTSASAAASQLI 264
>At5g25110 [T] KOG0583 Serine/threonine protein kinase
Length = 460
Score = 120 bits (302), Expect = 6e-27
Identities = 86/297 (28%), Positives = 141/297 (46%), Gaps = 11/297 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQI---EFEDESELNEHMLEIDLLKNLRHQN 66
Y + +++G+G +G VY + T + AIK I + + E + + EI +++ +RH N
Sbjct: 15 YEMGRLLGKGTFGKVYYGKEITTGESVAIKIINKDQVKREGMMEQIKREISIMRLVRHPN 74
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
IVE + + +++ I+EY G L + G L ED Y Q + + + H +GV
Sbjct: 75 IVELKEVMATKTKIFFIMEYVKGGELFSKIVKGKLKEDSARKYFQQLISAVDFCHSRGVS 134
Query: 127 HRDIKAANLLLTEEGIVKLADFGVSTRINRMAM-----TYAGSPNWMAPEVMTGQG-AST 180
HRD+K NLL+ E G +K++DFG+S ++ T G+P ++APEV+ +G
Sbjct: 135 HRDLKPENLLVDENGDLKVSDFGLSALPEQILQDGLLHTQCGTPAYVAPEVLRKKGYDGA 194
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
DIWS G + LL G PF + I E+ P S E K +S+ +
Sbjct: 195 KGDIWSCGIILYVLLAGFLPFQDENLMKMYRKIFKSEFEYPPWFSPESKRLISKLLVVDP 254
Query: 241 FKRATAQELLAHIWLKK-IQKP-KSKINLAEYIEKDGKWDVDFVLDSNTDMTPSPTK 295
KR + ++ W +K I P + KI+ E + + + T TP K
Sbjct: 255 NKRISIPAIMRTPWFRKNINSPIEFKIDELEIQNVEDETPTTTATTATTTTTPVSPK 311
>At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 257
Score = 120 bits (302), Expect = 6e-27
Identities = 77/236 (32%), Positives = 124/236 (51%), Gaps = 11/236 (4%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFED-ESELNEHML-EIDLLKNLRHQ 65
G Y + + IG G++ VV+ A R AIK+I + +L E ++ EI +L+ + H
Sbjct: 10 GDYLVGRQIGSGSFSVVWEARHRVDGTEVAIKEIAMDRLNKKLQESLMSEIFILRRINHP 69
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NI+ I+ +++++LEYC G L + +HG + E +++ Q GLQ L +
Sbjct: 70 NIIRLIDMIKSPGKVHLVLEYCKGGDLSVYVQRHGIVPEATAKHFMQQLAAGLQVLRDNN 129
Query: 125 VIHRDIKAANLLLT---EEGIVKLADFGVSTRINR--MAMTYAGSPNWMAPEVMTGQGAS 179
+IHRD+K NLLL+ + +K+ADFG + + +A T GSP +MAPE+M Q
Sbjct: 130 IIHRDLKPQNLLLSTNENDADLKIADFGFARSLQPRGLAETLCGSPLYMAPEIMQLQKYD 189
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRC 235
+D+WS+GA + +L+TG PF S + N L +C+D C
Sbjct: 190 AKADLWSVGAILFQLVTGRTPF---TGNSQIQLLQNIIRSTELHFPGDCRDLSLDC 242
>Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase
Length = 735
Score = 120 bits (301), Expect = 8e-27
Identities = 80/263 (30%), Positives = 135/263 (50%), Gaps = 14/263 (5%)
Query: 10 YALKQVIGRGAYGVVY--RAVKRGTNKPCAIKQIEFEDESELNEHM---LEIDLLKNLRH 64
+ L +V+G+G++G V+ R V R + ++ + ++ + + +E D+L ++ H
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 121
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
+V+ Q +LY+IL++ G L L K E+D Y+ + GL +LH
Sbjct: 122 PFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSL 181
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGAST 180
G+I+RD+K N+LL EEG +KL DFG+S + A ++ G+ +MAPEV+ QG S
Sbjct: 182 GIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSH 241
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
+D WS G + E+LTG+ PF + I+ + P LS E + L F++N
Sbjct: 242 SADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNP 301
Query: 241 FKRA-----TAQELLAHIWLKKI 258
R A+E+ H++ I
Sbjct: 302 ANRLGSGPDGAEEIKRHVFYSTI 324
Score = 118 bits (296), Expect = 3e-26
Identities = 87/322 (27%), Positives = 153/322 (47%), Gaps = 33/322 (10%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNL 62
N + Y +K+ IG G+Y R V + TN A+K I+ E +EI LL+
Sbjct: 411 NLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEE--IEI-LLRYG 467
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTL-YGLQYLH 121
+H NI+ + +Y++ E G L D + + ++V T+ ++YLH
Sbjct: 468 QHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLH 527
Query: 122 EQGVIHRDIKAANLLLTEEG----IVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMT 174
QGV+HRD+K +N+L +E +++ DFG + ++ N + MT + N++APEV+
Sbjct: 528 SQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 587
Query: 175 GQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL------------ 222
QG DIWSLG + +L G PF N +++ EE + +
Sbjct: 588 RQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTP------EEILTRIGSGKFTLSGGNW 641
Query: 223 -TLSAECKDFLSRCFQKNMFKRATAQELLAHIWL-KKIQKPKSKINLAEYIEKDGKWDVD 280
T+S KD +S+ + +R TA+++L H W+ +K + P+S+++ + G
Sbjct: 642 NTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQLSHQDLQLVKGAMAAT 701
Query: 281 FVLDSNTDMTPSPTKSPIQEDL 302
+ + P+P PI+ +
Sbjct: 702 Y--SALNSSKPTPQLKPIESSI 721
>CE23702 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 855
Score = 120 bits (301), Expect = 8e-27
Identities = 63/202 (31%), Positives = 114/202 (56%), Gaps = 13/202 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGFIQ 75
+G G+ G V+R N+ A+K++ E+E+ L++LRHQNI+E+ G
Sbjct: 68 LGSGSQGAVFRGQLE--NRTVAVKKVNQLKETEIKH-------LRHLRHQNIIEFLGVCS 118
Query: 76 KAHELYIILEYCARGSLRDILK-HGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAAN 134
K+ I++EYC++G L +LK + + +V + G+ YLH+ VIHRD+K+ N
Sbjct: 119 KSPCYCIVMEYCSKGQLCTVLKSRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPN 178
Query: 135 LLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEVMTGQGASTVSDIWSLGATV 191
+L++ E +K+ DFG S +++ M++ G+ +WMAPE++ Q + D++S G +
Sbjct: 179 ILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVL 238
Query: 192 VELLTGNPPFHNLVNESACYAI 213
E+LT P+ N+ + + +
Sbjct: 239 WEMLTRETPYANIAQMAIIFGV 260
>CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 357
Score = 120 bits (301), Expect = 8e-27
Identities = 90/285 (31%), Positives = 137/285 (47%), Gaps = 38/285 (13%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE----------FED-------------- 45
Y L + IG+G+YG+V A A+K ++ F
Sbjct: 21 YRLMEEIGQGSYGIVKLAYNEEDKNLYALKVLDKMKLLKNFACFRQPPPRRNKENAAPSV 80
Query: 46 -ESELNEHMLEIDLLKNLRHQNIVEYRGFIQKAHE--LYIILEYCARGSLRDILKHGPLL 102
+ L EI +LK L H N+V+ + ++ LY++ E+ +GS+ +I PL
Sbjct: 81 LRNPLQLVQKEIAILKKLSHPNVVKLVEVLDDPNDNYLYMVFEFVEKGSILEIPTDKPLD 140
Query: 103 EDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTR---INRMAM 159
ED +Y TL GL+YLH Q ++HRDIK +NLLL++ G VK+ADFGVS I+
Sbjct: 141 EDTAWSYFRDTLCGLEYLHYQKIVHRDIKPSNLLLSDIGQVKIADFGVSCEFEGIDAFLS 200
Query: 160 TYAGSPNWMAPEVMTGQGAS-----TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIV 214
AG+P +MAPE +T +GA+ DIWSLG T+ + G PF + + I
Sbjct: 201 GTAGTPAFMAPEALT-EGANHFYSGRAQDIWSLGITLYAFVIGTVPFVDNYIIALHKKIK 259
Query: 215 NEEYIPPLT--LSAECKDFLSRCFQKNMFKRATAQELLAHIWLKK 257
N+ + P LS +D + +K+ R E+ H W+ +
Sbjct: 260 NDPIVFPEAPILSEALQDIILGMLKKDPGHRLMLHEVKVHTWVTR 304
>Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase
Length = 292
Score = 120 bits (301), Expect = 8e-27
Identities = 81/259 (31%), Positives = 129/259 (49%), Gaps = 12/259 (4%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEID--LLKNLRHQNI 67
Y +V+G+G+YG V R K IK++ + S E + LL L+H NI
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 68 VEYRGFIQKAHEL-YIILEYCARGSLRDILKH--GPLL-EDDTVNYVTQTLYGLQYLHEQ 123
V Y+ + L YI++ +C G L LK G LL E+ V + Q LQYLHE+
Sbjct: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRINR---MAMTYAGSPNWMAPEVMTGQGAST 180
++HRD+K N+ LT I+K+ D G++ + MA T G+P +M+PE+ + + +
Sbjct: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQK 238
SD+W+LG V E+ T F+ S Y I+ E +P P S E + + K
Sbjct: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRII-EGKLPAMPRDYSPELAELIRTMLSK 244
Query: 239 NMFKRATAQELLAHIWLKK 257
+R + + +L ++K+
Sbjct: 245 RPEERPSVRSILRQPYIKR 263
>YKL101w [D] KOG0588 Serine/threonine protein kinase
Length = 1518
Score = 120 bits (300), Expect = 1e-26
Identities = 75/228 (32%), Positives = 125/228 (53%), Gaps = 7/228 (3%)
Query: 37 AIKQIEFEDESELNEHMLE--IDLLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD 94
+I E + S+ N + +E I ++K + H N++ + ELY++LEY G L D
Sbjct: 144 SIASREHSNHSQTNPYGIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFD 203
Query: 95 IL-KHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAANLLLTEEGI-VKLADFGVST 152
L G L E + ++Y Q + G+ Y H + HRD+K NLLL ++ +K+ADFG++
Sbjct: 204 YLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAA 263
Query: 153 RI--NRMAMTYAGSPNWMAPEVMTGQGA-STVSDIWSLGATVVELLTGNPPFHNLVNESA 209
N++ T GSP++ +PE++ G+ SD+WS G + LLTG+ PF++ +
Sbjct: 264 LELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPFNDDNIKKL 323
Query: 210 CYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRATAQELLAHIWLKK 257
+ + +Y P LS+E +D +S+ + KR T QE+L H +KK
Sbjct: 324 LLKVQSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLIKK 371
>Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 514
Score = 120 bits (300), Expect = 1e-26
Identities = 74/266 (27%), Positives = 134/266 (49%), Gaps = 20/266 (7%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLE--IDLLKNLRHQNI 67
Y +++G+G++G+V A + T AIK++ E +LE +++LK+++H++I
Sbjct: 116 YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHI 175
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYG-LQYLHEQGVI 126
+ + ++Y+++E C G L++IL ++ ++ Q+L + YLH ++
Sbjct: 176 IHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIV 235
Query: 127 HRDIKAANLLLTEEGI---------VKLADFGVS----TRINRMAMTYAGSPNWMAPEVM 173
HRD+K N+++ I +K+ DFG++ +R M G+P +MAPEV+
Sbjct: 236 HRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVI 295
Query: 174 TGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAI----VNEEYIPPLTLSAECK 229
+ S DIWS+G + LL G PPF E I ++ E ++S K
Sbjct: 296 SAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAK 355
Query: 230 DFLSRCFQKNMFKRATAQELLAHIWL 255
L + + + R TA+ELL + WL
Sbjct: 356 SVLKQLMKVDPAHRITAKELLDNQWL 381
>Hs20127418 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 664
Score = 120 bits (300), Expect = 1e-26
Identities = 101/350 (28%), Positives = 160/350 (44%), Gaps = 31/350 (8%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEID--LLKNLRHQNI 67
Y L + IG+GA+ VV R VK T A K I + S + LE + + + L+H NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 68 VEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
V I + Y++ + G L DI+ E D + + Q L + + H+ GV+
Sbjct: 74 VRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 133
Query: 127 HRDIKAANLLLTEE---GIVKLADFGVSTRIN---RMAMTYAGSPNWMAPEVMTGQGAST 180
HRD+K NLLL + VKLADFG++ + + +AG+P +++PEV+ +
Sbjct: 134 HRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGK 193
Query: 181 VSDIWSLGATVVELLTGNPPF-----HNLVNE--SACYAIVNEEYIPPLTLSAECKDFLS 233
DIW+ G + LL G PPF H L + + Y + E+ T++ E K+ ++
Sbjct: 194 PVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWD---TVTPEAKNLIN 250
Query: 234 RCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSN--TDMTP 291
+ N KR TA E L H W+ + S ++ E +E K++ L T M
Sbjct: 251 QMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLA 310
Query: 292 SPTKSPIQEDLAPADFRTLSVDQLFIEHSTDSIVVGLIKTLNELTAIKAD 341
+ S ++ APA T + +GL++ L KAD
Sbjct: 311 TRNFSVGRQTTAPATMST----------AASGTTMGLVEQAKSLLNKKAD 350
>Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 302
Score = 120 bits (300), Expect = 1e-26
Identities = 84/257 (32%), Positives = 133/257 (51%), Gaps = 19/257 (7%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEH---MLEIDLL 59
N++A+ + +++ IGRG + VYRA P A+K+++ D + + EIDLL
Sbjct: 29 NTLAN--FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLL 86
Query: 60 KNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGP----LLEDDTV-NYVTQTL 114
K L H N+++Y + +EL I+LE G L ++KH L+ + TV Y Q
Sbjct: 87 KQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146
Query: 115 YGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPE 171
L+++H + V+HRDIK AN+ +T G+VKL D G+ + A + G+P +M+PE
Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPE 206
Query: 172 VMTGQGASTVSDIWSLGATVVELLTGNPPFH--NLVNESACYAIVNEEYIPPLT---LSA 226
+ G + SDIWSLG + E+ PF+ + S C I +Y PPL S
Sbjct: 207 RIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDY-PPLPSDHYSE 265
Query: 227 ECKDFLSRCFQKNMFKR 243
E + ++ C + KR
Sbjct: 266 ELRQLVNMCINPDPEKR 282
>Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 795
Score = 120 bits (300), Expect = 1e-26
Identities = 83/287 (28%), Positives = 141/287 (48%), Gaps = 21/287 (7%)
Query: 14 QVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLRHQNIVEYRGF 73
+V+G G +G V+R ++ T P A K I+ + + + EI+++ L H N+++
Sbjct: 495 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDA 554
Query: 74 IQKAHELYIILEYCARGSLRDIL--KHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIK 131
+ H +++EY G L D + + L E D V + Q G+ YLH+ ++H D+K
Sbjct: 555 FESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLDLK 614
Query: 132 AANLLLTEE--GIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGASTVSDIWS 186
N+L + +K+ DFG++ R ++ + + G+P ++APEV+ + S +D+WS
Sbjct: 615 PENILCVNQTGHQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYEFVSFPTDMWS 673
Query: 187 LGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLT----LSAECKDFLSRCFQKNMFK 242
+G LL+G PF + IVN + LS E KDF+SR K
Sbjct: 674 VGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSC 733
Query: 243 RATAQELLAHIWLKKI--------QKPKSKINLAEYIEKDGKWDVDF 281
R +A + L H WL + + KS++ L +YI + KW F
Sbjct: 734 RMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQ-RKWKKHF 779
>At3g20860 [R] KOG0589 Serine/threonine protein kinase
Length = 427
Score = 120 bits (300), Expect = 1e-26
Identities = 74/252 (29%), Positives = 128/252 (50%), Gaps = 10/252 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNE--HMLEIDLLKNLRHQNI 67
Y + + IGRGA+G + + + + +K+I ++E + + E+ L+ L+ I
Sbjct: 15 YEVVEQIGRGAFGSAFLVIHKSERRKYVVKKIRLAKQTERCKLAAIQEMSLISKLKSPYI 74
Query: 68 VEYRGFIQKAHELYIILEYCARGSLRDILKHGPLL---EDDTVNYVTQTLYGLQYLHEQG 124
VEY+ + + I+ YC G + ++K + E+ ++ Q L + YLH
Sbjct: 75 VEYKDSWVEKDCVCIVTSYCEGGDMTQMIKKSRGVFASEEKLCRWMVQLLLAIDYLHNNR 134
Query: 125 VIHRDIKAANLLLTEEGIVKLADFGVSTRINR--MAMTYAGSPNWMAPEVMTGQGASTVS 182
V+HRD+K +N+ LT+E V+L DFG++ + + +A + G+PN+M PE++ S
Sbjct: 135 VLHRDLKCSNIFLTKENEVRLGDFGLAKLLGKDDLASSMVGTPNYMCPELLADIPYGYKS 194
Query: 183 DIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL--SAECKDFLSRCFQKNM 240
DIWSLG + E+ P F + +A +N + PL + S+ K + +KN
Sbjct: 195 DIWSLGCCMFEVAAHQPAF-KAPDMAALINKINRSSLSPLPVMYSSSLKRLIKSMLRKNP 253
Query: 241 FKRATAQELLAH 252
R TA ELL H
Sbjct: 254 EHRPTAAELLRH 265
>YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 447
Score = 119 bits (299), Expect = 1e-26
Identities = 84/275 (30%), Positives = 132/275 (47%), Gaps = 21/275 (7%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE----DESELNEHMLEIDLLKNLRHQ 65
Y + +G G++GVV +A K TN+ AIK + + + +L E+ +L+ L H
Sbjct: 47 YIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHP 106
Query: 66 NIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQG 124
NIV ++ + + + YI+ + G L D IL G E D V + Q L ++Y+H +
Sbjct: 107 NIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKN 166
Query: 125 VIHRDIKAANLLL---TEEGIVKLADFGVSTRI---NRMAMTYAGSPNWMAPEVMTGQGA 178
V+HRD+K N+L +E + +ADFG++ ++ + AGS ++APEV+T G
Sbjct: 167 VVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGH 226
Query: 179 STVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLT--------LSAECKD 230
DIWS+G LL G PF E Y P+T +S + K
Sbjct: 227 GKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRY--PVTFHMPYWDNISIDVKR 284
Query: 231 FLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKI 265
F+ + + N R TA ELL W+ + S I
Sbjct: 285 FILKALRLNPADRPTATELLDDPWITSKRVETSNI 319
>CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 336
Score = 119 bits (299), Expect = 1e-26
Identities = 76/270 (28%), Positives = 131/270 (48%), Gaps = 25/270 (9%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIK-----QIEFEDESELNEHML---------- 54
Y + +IG+G + V+ ++ CA+K ++F S+ + +
Sbjct: 57 YEIGAIIGKGNFSSVHLTRRKEDGTKCALKVRYQSTLQFSFPSKFFQQVEKRAMRGKCFF 116
Query: 55 ---EIDLLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYV 110
E+++L ++H +I+ ++ +I+ E+ G L + I K+G + E D
Sbjct: 117 VDNEVEMLSLIQHDHIISIIDAFSTENQYFIVFEHAQYGDLYETIRKNGRIEEPDAAIIT 176
Query: 111 TQTLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAP 170
Q L YLHE+ V+HRD+K NLLL ++ VKL DFG++ I G+P + AP
Sbjct: 177 LQVASALNYLHERNVVHRDVKPENLLLVDKFSVKLCDFGLACHILGPLYRICGTPTYCAP 236
Query: 171 EVMTGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIV-----NEEYIPPLTLS 225
EV+ G ST DIWSLG + +L G PF +++ + ++ N + +S
Sbjct: 237 EVLRETGYSTRCDIWSLGVVLYVMLVGYAPF-RAPDQTRLFKLIMQAKPNLDMPEWKGIS 295
Query: 226 AECKDFLSRCFQKNMFKRATAQELLAHIWL 255
+ KD +SR K +R A +++AH W+
Sbjct: 296 LKAKDLVSRLMNKTEERRPLASQIMAHPWI 325
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 119 bits (299), Expect = 1e-26
Identities = 88/270 (32%), Positives = 143/270 (52%), Gaps = 17/270 (6%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLKNLR-HQNIVEYRG-- 72
IG GA VV RA+ ++ A+K+I + + + + EI L H+ +V++ G
Sbjct: 89 IGSGASSVVQRAIHIPNHRILALKKINIFEREKRQQLLTEIRTLCEAPCHEGLVDFHGAF 148
Query: 73 FIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVT-QTLYGLQYLHE-QGVIHRDI 130
+ + ++ I LEY GSL DILK + + ++ + + L GL YLH + ++HRDI
Sbjct: 149 YSPDSGQISIALEYMNGGSLADILKVTKKIPEPVLSSLFHKLLQGLSYLHGVRHLVHRDI 208
Query: 131 KAANLLLTEEGIVKLADFGVSTRI-NRMAM--TYAGSPNWMAPEVMTGQGASTVSDIWSL 187
K ANLL+ +G K+ DFG+S + N MAM T+ G+ +M+PE + S +DIWSL
Sbjct: 209 KPANLLINLKGEPKITDFGISAGLENSMAMCATFVGTVTYMSPERIRNDSYSYPADIWSL 268
Query: 188 GATVVELLTGNPPFHNLVNESACYAIVN-----EEYIPPLTLSAECKDFLSRCFQKNMFK 242
G + E TG P+ + NE ++ P S E F+ C QK+
Sbjct: 269 GLALFECGTGEFPY--IANEGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQKDPDA 326
Query: 243 RATAQELLAHIWLKKIQKPKSKINLAEYIE 272
R TA +LL+H ++ K + K +++LA +++
Sbjct: 327 RPTADQLLSHPFITKHE--KERVDLATFVQ 354
>At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 348
Score = 119 bits (299), Expect = 1e-26
Identities = 84/258 (32%), Positives = 132/258 (50%), Gaps = 22/258 (8%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-EIDLLKNLRHQNIVEYRGFI 74
IG GA G VY+ + T++P A+K I E + + EI++L+++ H N+V+
Sbjct: 76 IGSGAGGTVYKVIHTPTSRPFALKVIYGNHEDTVRRQICREIEILRSVDHPNVVKCHDMF 135
Query: 75 QKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVIHRDIKAAN 134
E+ ++LE+ +GSL E + + Q L GL YLH + ++HRDIK +N
Sbjct: 136 DHNGEIQVLLEFMDQGSLEGA---HIWQEQELADLSRQILSGLAYLHRRHIVHRDIKPSN 192
Query: 135 LLLTEEGIVKLADFGVSTRINRMAM----TYAGSPNWMAPEVMT-----GQGASTVSDIW 185
LL+ VK+ADFGVS RI M + G+ +M+PE + G+ D+W
Sbjct: 193 LLINSAKNVKIADFGVS-RILAQTMDPCNSSVGTIAYMSPERINTDLNHGRYDGYAGDVW 251
Query: 186 SLGATVVELLTGNPPFHNLVNESA------CYAIVNEEYIPPLTLSAECKDFLSRCFQKN 239
SLG +++E G PF V+ C +++ P T S E + F+S C Q +
Sbjct: 252 SLGVSILEFYLGRFPF--AVSRQGDWASLMCAICMSQPPEAPATASQEFRHFVSCCLQSD 309
Query: 240 MFKRATAQELLAHIWLKK 257
KR +AQ+LL H ++ K
Sbjct: 310 PPKRWSAQQLLQHPFILK 327
>SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 605
Score = 119 bits (298), Expect = 2e-26
Identities = 81/258 (31%), Positives = 132/258 (50%), Gaps = 14/258 (5%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFE-DESELNEHMLEIDLLKNLRHQNIVEYRGFI 74
+G+G YGVVY+A+ + T A+K+I +E+ N+ ++E+D+L IV++ G
Sbjct: 326 LGKGNYGVVYKALHQPTGVTMALKEIRLSLEEATFNQIIMELDILHKAVSPYIVDFYGAF 385
Query: 75 QKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQ-GVIHRDIKAA 133
++I +EY GS+ + G E + GL+ L E+ +IHRD+K
Sbjct: 386 FVEGSVFICMEYMDAGSMDKLYAGGIKDEGVLARTAYAVVQGLKTLKEEHNIIHRDVKPT 445
Query: 134 NLLLTEEGIVKLADFGVS-TRINRMAMTYAGSPNWMAPEVMTGQGA-------STVSDIW 185
N+L+ G VKL DFGVS + ++ T G ++MAPE + G + +D+W
Sbjct: 446 NVLVNSNGQVKLCDFGVSGNLVASISKTNIGCQSYMAPERIRVGGPTNGVLTYTVQADVW 505
Query: 186 SLGATVVELLTGNPPF--HNLVNESACYAIVNEEYIP--PLTLSAECKDFLSRCFQKNMF 241
SLG T++E+ G P+ + + A + + + P P + S E +DF+++C KN
Sbjct: 506 SLGLTILEMALGAYPYPPESYTSIFAQLSAICDGDPPSLPDSFSPEARDFVNKCLNKNPS 565
Query: 242 KRATAQELLAHIWLKKIQ 259
R EL H WL K Q
Sbjct: 566 LRPDYHELANHPWLLKYQ 583
>Hs21361133 [R] KOG0586 Serine/threonine protein kinase
Length = 752
Score = 119 bits (298), Expect = 2e-26
Identities = 100/401 (24%), Positives = 177/401 (43%), Gaps = 40/401 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHML-----EIDLLKNL 62
G Y L + IG+G + V A T + AIK I D+++LN L E+ ++K L
Sbjct: 54 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKII---DKTQLNPTSLQKLFREVRIMKIL 110
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQ--------- 112
H NIV+ I+ LY+I+EY + G + D L HG + E + + Q
Sbjct: 111 NHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGKMKEKEARSKFRQGCQAGQTIK 170
Query: 113 --------------TLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTR--INR 156
+ +QY H++ ++HRD+KA NLLL + +K+ADFG S +
Sbjct: 171 VQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG 230
Query: 157 MAMTYAGSPNWMAPEVMTGQGASTVS-DIWSLGATVVELLTGNPPFHNLVNESACYAIVN 215
T+ GSP + APE+ G+ D+WSLG + L++G+ PF + ++
Sbjct: 231 KLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLR 290
Query: 216 EEYIPPLTLSAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDG 275
+Y P +S +C++ L R N KR T ++++ W I + L ++E +
Sbjct: 291 GKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRW---INAGHEEDELKPFVEPEL 347
Query: 276 KWDVDFVLDSNTDMTPSPTKSPIQEDLAPADFRTLSVDQLFIEHSTDSIVVGLIKTLNEL 335
+D M S + IQE L+ + ++ L + + + + + L
Sbjct: 348 DISDQKRIDIMVGMGYS--QEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNL 405
Query: 336 TAIKADATASGSLSNRTFEILKYDKQFNHTALKEKFIDNGG 376
+ K ++ + S K + + + + ++ D+ G
Sbjct: 406 SLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAG 446
>CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 348
Score = 119 bits (298), Expect = 2e-26
Identities = 80/264 (30%), Positives = 132/264 (49%), Gaps = 11/264 (4%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAV-KRGTNKPCAIKQIEFEDESELNEHML-EIDLLK 60
N+ Y + V+G GA+ V+ A K + A+K I+ + E + EI +L+
Sbjct: 15 NATIREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLENEIKVLR 74
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQY 119
LRH NIV+ + +Y+++E G L D I+ G E D N + Q L + +
Sbjct: 75 KLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQVLEAVGF 134
Query: 120 LHEQGVIHRDIKAANLLL---TEEGIVKLADFGVS-TRINRMAMTYAGSPNWMAPEVMTG 175
+H+ GV+HRD+K NLL E+ + ++DFG+S T + + T G+P ++APEV+
Sbjct: 135 MHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSKTEDSGVMATACGTPGYVAPEVLQQ 194
Query: 176 QGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPL----TLSAECKDF 231
+ D+WS+G LL G PPF++ + + I+ EY +S KDF
Sbjct: 195 KPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDF 254
Query: 232 LSRCFQKNMFKRATAQELLAHIWL 255
++ + R T Q+ L+H W+
Sbjct: 255 ITHLMCCDPEARFTCQDALSHPWI 278
>At5g01810 [T] KOG0583 Serine/threonine protein kinase
Length = 421
Score = 119 bits (298), Expect = 2e-26
Identities = 82/276 (29%), Positives = 133/276 (47%), Gaps = 9/276 (3%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN---EHMLEIDLLKNLRHQN 66
Y + + +G+G + VY A T AIK I+ E ++ + EI ++ LRH N
Sbjct: 12 YEVGKFLGQGTFAKVYHARHLKTGDSVAIKVIDKERILKVGMTEQIKREISAMRLLRHPN 71
Query: 67 IVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
IVE + ++Y ++E+ G L + + G L ED Y Q + + + H +GV
Sbjct: 72 IVELHEVMATKSKIYFVMEHVKGGELFNKVSTGKLREDVARKYFQQLVRAVDFCHSRGVC 131
Query: 127 HRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTGQGASTV 181
HRD+K NLLL E G +K++DFG+S R + + T G+P ++APEV++ G
Sbjct: 132 HRDLKPENLLLDEHGNLKISDFGLSALSDSRRQDGLLHTTCGTPAYVAPEVISRNGYDGF 191
Query: 182 -SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
+D+WS G + LL G PF + I E P L+ K L R N
Sbjct: 192 KADVWSCGVILFVLLAGYLPFRDSNLMELYKKIGKAEVKFPNWLAPGAKRLLKRILDPNP 251
Query: 241 FKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGK 276
R + ++++ W +K + + K ++ E E D +
Sbjct: 252 NTRVSTEKIMKSSWFRKGLQEEVKESVEEETEVDAE 287
>SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase
Length = 891
Score = 119 bits (297), Expect = 2e-26
Identities = 88/274 (32%), Positives = 130/274 (47%), Gaps = 27/274 (9%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIK------------------QIEFEDESEL 49
G Y L + IG G+ G V A T + AIK + +SE
Sbjct: 123 GNYVLGKTIGAGSMGKVKVAHHLKTGEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEK 182
Query: 50 NEHML---EIDLLKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDD 105
N+ + E L LRH I E R Y++ E+ G + D I+ HG L E
Sbjct: 183 NKEIRTVREAALSTLLRHPYICEARDVYITNSHYYMVFEFVDGGQMLDYIISHGKLKEKQ 242
Query: 106 TVNYVTQTLYGLQYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRINRMA--MTYAG 163
+V Q L YLH+ V+HRD+K N+L+++ G +K+ DFG+S R + T+ G
Sbjct: 243 ARKFVRQIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGLSNLYRRQSRLRTFCG 302
Query: 164 SPNWMAPEVMTGQG-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIP-P 221
S + APE++ Q D+WS G + L+ G PF + N SA +A + + + P
Sbjct: 303 SLYFAAPELLNAQPYIGPEVDVWSFGIVLYVLVCGKVPFDD-QNMSALHAKIKKGTVEYP 361
Query: 222 LTLSAECKDFLSRCFQKNMFKRATAQELLAHIWL 255
LS++CK LSR + KRAT +E+L H W+
Sbjct: 362 SYLSSDCKGLLSRMLVTDPLKRATLEEVLNHPWM 395
>CE21025 [D] KOG0580 Serine/threonine protein kinase
Length = 326
Score = 119 bits (297), Expect = 2e-26
Identities = 75/252 (29%), Positives = 133/252 (52%), Gaps = 7/252 (2%)
Query: 16 IGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELN-EHML--EIDLLKNLRHQNIVEYRG 72
+G+G +G V+ + ++ T + A+K + +L H L EI++ +LRH NI+ G
Sbjct: 50 LGKGKFGNVFISREKKTKRIIALKVLFKTQLLQLGVSHQLKREIEIQYHLRHPNILTLYG 109
Query: 73 FIQKAHELYIILEYCARGSLRDILKHGPLLEDDTV---NYVTQTLYGLQYLHEQGVIHRD 129
+ +++IL+Y +RG L ++L+ P + + V +V Q L Y H +GVIHRD
Sbjct: 110 YFHDDKRVFVILDYASRGELFNVLQSQPGHKVNEVIAGRFVRQLANALHYCHSKGVIHRD 169
Query: 130 IKAANLLLTEEGIVKLADFGVSTRINRMAM-TYAGSPNWMAPEVMTGQGASTVSDIWSLG 188
IK NLLL + +KLADFG S + T G+ +++APE+++ Q DIW++G
Sbjct: 170 IKPENLLLDSKLNLKLADFGWSVVADHSKRHTLCGTMDYLAPEMVSNQPHDFNVDIWAIG 229
Query: 189 ATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMFKRATAQE 248
+ E+L G PF N + I + P ++ ++ +K +R +
Sbjct: 230 ILLFEMLVGYAPFANQTGDKLIARIKECKIYIPSVVTDGAASLINAIIKKEPQERLPLVD 289
Query: 249 LLAHIWLKKIQK 260
++AH W+K++++
Sbjct: 290 IMAHPWIKEMKQ 301
>CE00847 [T] KOG0583 Serine/threonine protein kinase
Length = 622
Score = 119 bits (297), Expect = 2e-26
Identities = 74/256 (28%), Positives = 125/256 (47%), Gaps = 7/256 (2%)
Query: 8 GTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE---FEDESELNEHMLEIDLLKNLRH 64
G + +K+ IG+GA+G V R T AIK + + +N+ EID L+ L H
Sbjct: 22 GNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTH 81
Query: 65 QNIVEYRGFIQKAHELYIILEYCARGSLRD-ILKHGPLLEDDTVNYVTQTLYGLQYLHEQ 123
+I I ++++++E + G L I + G L ++ Y Q + G+ Y H
Sbjct: 82 PHITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALPIRESRRYFQQIISGVSYCHNH 141
Query: 124 GVIHRDIKAANLLLTEEGIVKLADFGVSTRI--NRMAMTYAGSPNWMAPEVMTGQ-GAST 180
++HRD+K NLLL +K+ADFG+S + + T GSPN+ APE+++ +
Sbjct: 142 MIVHRDLKPENLLLDANKNIKIADFGLSNYMTDGDLLSTACGSPNYAAPELISNKLYVGP 201
Query: 181 VSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSRCFQKNM 240
D+WS G + +L G PF + + I + Y P ++ + D +S Q +
Sbjct: 202 EVDLWSCGVILYAMLCGTLPFDDQNVPTLFAKIKSGRYTVPYSMEKQAADLISTMLQVDP 261
Query: 241 FKRATAQELLAHIWLK 256
KRA + ++ H W +
Sbjct: 262 VKRADVKRIVNHSWFR 277
>At5g58380 [T] KOG0583 Serine/threonine protein kinase
Length = 464
Score = 119 bits (297), Expect = 2e-26
Identities = 82/283 (28%), Positives = 133/283 (46%), Gaps = 17/283 (6%)
Query: 4 SIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESE---LNEHMLEIDLLK 60
S+ Y + +++G+G + VY TN+ AIK I+ E + + + EI +++
Sbjct: 6 SVLTDKYDVGRLLGQGTFAKVYYGRSILTNQSVAIKMIDKEKVMKVGLIEQIKREISVMR 65
Query: 61 NLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVTQTLYGLQYL 120
RH N+VE + +Y ++EYC G L + + G L +D Y Q + + +
Sbjct: 66 IARHPNVVELYEVMATKTRIYFVMEYCKGGELFNKVAKGKLRDDVAWKYFYQLINAVDFC 125
Query: 121 HEQGVIHRDIKAANLLLTEEGIVKLADFGVST-----RINRMAMTYAGSPNWMAPEVMTG 175
H + V HRDIK NLLL + +K++DFG+S R + + T G+P ++APEV+
Sbjct: 126 HSREVYHRDIKPENLLLDDNENLKVSDFGLSALADCKRQDGLLHTTCGTPAYVAPEVINR 185
Query: 176 QG-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTLSAECKDFLSR 234
+G T +DIWS G + LL G PFH+ I ++ P + E + L +
Sbjct: 186 KGYDGTKADIWSCGVVLFVLLAGYLPFHDSNLMEMYRKIGKADFKAPSWFAPEVRRLLCK 245
Query: 235 CFQKNMFKRATAQELLAHIWL--------KKIQKPKSKINLAE 269
N R T + W KK++K +IN E
Sbjct: 246 MLDPNPETRITIARIRESSWFRKGLHMKQKKMEKRVKEINSVE 288
>At1g32320 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 305
Score = 119 bits (297), Expect = 2e-26
Identities = 79/255 (30%), Positives = 130/255 (50%), Gaps = 17/255 (6%)
Query: 15 VIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHM-LEIDLLKNLRHQNIVEYRGF 73
V+G+G+ G VY+ R T A+K + LN + +E D+LK + I++
Sbjct: 53 VLGQGSGGTVYKTRHRRTKTLYALKVLR----PNLNTTVTVEADILKRIESSFIIKCYAV 108
Query: 74 IQKAHELYIILEYCARGSLRDILKHGPLLEDDTVNYVT-QTLYGLQYLHEQGVIHRDIKA 132
++L ++E +GSL D L + + V+ + + L GL+YL + G++H DIK
Sbjct: 109 FVSLYDLCFVMELMEKGSLHDALLAQQVFSEPMVSSLANRILQGLRYLQKMGIVHGDIKP 168
Query: 133 ANLLLTEEGIVKLADFGVSTRINRMAMTYAGSPNWMAPEVMT------GQGASTVSDIWS 186
+NLL+ ++G VK+ADFG S + G+ +M+PE + G D+WS
Sbjct: 169 SNLLINKKGEVKIADFGASRIVAGGDYGSNGTCAYMSPERVDLEKWGFGGEVGFAGDVWS 228
Query: 187 LGATVVELLTGNPPFHNLVNES-----ACYAIVNEEYIPPLTLSAECKDFLSRCFQKNMF 241
LG V+E G P + ++ C NE+ P++ S E +DF+ RC +K+
Sbjct: 229 LGVVVLECYIGRYPLTKVGDKPDWATLFCAICCNEKVDIPVSCSLEFRDFVGRCLEKDWR 288
Query: 242 KRATAQELLAHIWLK 256
KR T +ELL H ++K
Sbjct: 289 KRDTVEELLRHSFVK 303
>CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 518
Score = 118 bits (296), Expect = 3e-26
Identities = 104/383 (27%), Positives = 174/383 (45%), Gaps = 24/383 (6%)
Query: 10 YALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEID--LLKNLRHQNI 67
Y +K+ +G+GA+ VV R V + T A K I + S + LE + + + L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 68 VEYRGFIQKAHELYIILEYCARGSL-RDILKHGPLLEDDTVNYVTQTLYGLQYLHEQGVI 126
V IQ+ Y++ + G L DI+ E D + + Q L + Y H G++
Sbjct: 72 VRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIV 131
Query: 127 HRDIKAANLLLTEEG---IVKLADFGVSTRINRMAMT--YAGSPNWMAPEVMTGQGASTV 181
HRD+K NLLL + VKLADFG++ +N +AG+P +++PEV+ S
Sbjct: 132 HRDLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKP 191
Query: 182 SDIWSLGATVVELLTGNPPFHNLVNESACYAIVNE---EYIPPL--TLSAECKDFLSRCF 236
DIW+ G + LL G PPF + ++ YA + +Y P T++ E K +
Sbjct: 192 VDIWACGVILYILLVGYPPFWD-EDQHRLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSML 250
Query: 237 QKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDGKWDVDFVLDSNTDMTPSPTKS 296
N KR TA + L W+ ++ S I+ + ++ K++ L T T++
Sbjct: 251 TVNPKKRITADQALKVPWICNRERVASAIHRQDTVDCLKKFNARRKLKGAILTTMIATRN 310
Query: 297 PIQEDL-------APADFRTLSVDQLFIEHSTDSIVVGLIKTLNELTAIKADATASGSLS 349
+L P+ + S I+ + G +K +E T ++AD A+G +S
Sbjct: 311 LSSRNLLNKKEQGPPSTIKESSESSQTIDDNDSEKGGGQLK--HENTVVRADG-ATGIVS 367
Query: 350 NRTFEILKYDKQFNHTALKEKFI 372
+ N +A K+ +
Sbjct: 368 SSNSSTASKSSSTNLSAQKQDIV 390
>At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 354
Score = 118 bits (296), Expect = 3e-26
Identities = 100/293 (34%), Positives = 151/293 (51%), Gaps = 23/293 (7%)
Query: 1 MDNSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFEDESELNEHMLEIDLLK 60
+DN ++ + +VIG+G+ G V + T + A+K I+ E E + +L
Sbjct: 59 LDNQLSLADLEVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLNTE-ESTCRAISQELRI 117
Query: 61 NLRHQN---IVEYRGFIQKAHELYIILEYCARGSLRDILKH-GPLLEDDTVNYVTQTLYG 116
NL Q + Y+ F + IILE+ GSL D+LK G + E+ + L G
Sbjct: 118 NLSSQCPYLVSCYQSFYHNGL-VSIILEFMDGGSLADLLKKVGKVPENMLSAICKRVLRG 176
Query: 117 LQYLH-EQGVIHRDIKAANLLLTEEGIVKLADFGVS---TRINRMAMTYAGSPNWMAPEV 172
L Y+H E+ +IHRD+K +NLL+ G VK+ DFGVS T + +A ++ G+ +M+PE
Sbjct: 177 LCYIHHERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSSLANSFVGTYPYMSPER 236
Query: 173 MTGQGASTVSDIWSLGATVVELLTG----NPPFHNLVNESACYAIVNE--EYIPPLT--- 223
++G S SDIWSLG ++E TG PP H S+ Y +V+ E PP
Sbjct: 237 ISGSLYSNKSDIWSLGLVLLECATGKFPYTPPEHK-KGWSSVYELVDAIVENPPPCAPSN 295
Query: 224 -LSAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYIEKDG 275
S E F+S+C QK+ R +A+ELL H ++K + S NL+ Y G
Sbjct: 296 LFSPEFCSFISQCVQKDPRDRKSAKELLEHKFVKMFE--DSDTNLSAYFTDAG 346
>At2g25090 [T] KOG0583 Serine/threonine protein kinase
Length = 469
Score = 118 bits (296), Expect = 3e-26
Identities = 83/287 (28%), Positives = 138/287 (47%), Gaps = 18/287 (6%)
Query: 3 NSIAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIE----FEDESELNEHMLEIDL 58
+++ Y + +++G G + VY + T AIK I+ F+ + + EI +
Sbjct: 8 STVLFDKYNIGRLLGTGNFAKVYHGTEISTGDDVAIKVIKKDHVFKRRGMMEQIEREIAV 67
Query: 59 LKNLRHQNIVEYRGFIQKAHELYIILEYCARGSLRDIL-KHGPLLEDDTVNYVTQTLYGL 117
++ LRH N+VE R + +++ ++EY G L +++ + G L ED Y Q + +
Sbjct: 68 MRLLRHPNVVELREVMATKKKIFFVMEYVNGGELFEMIDRDGKLPEDLARKYFQQLISAV 127
Query: 118 QYLHEQGVIHRDIKAANLLLTEEGIVKLADFGVSTRI------------NRMAMTYAGSP 165
+ H +GV HRDIK NLLL EG +K+ DFG+S + + + T G+P
Sbjct: 128 DFCHSRGVFHRDIKPENLLLDGEGDLKVTDFGLSALMMPEGLGGRRGSSDDLLHTRCGTP 187
Query: 166 NWMAPEVMTGQG-ASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNEEYIPPLTL 224
++APEV+ +G ++DIWS G + LL G PF + + I E P
Sbjct: 188 AYVAPEVLRNKGYDGAMADIWSCGIVLYALLAGFLPFIDENVMTLYTKIFKAECEFPPWF 247
Query: 225 SAECKDFLSRCFQKNMFKRATAQELLAHIWLKKIQKPKSKINLAEYI 271
S E K+ LSR + +R + E+ W +K P ++ E I
Sbjct: 248 SLESKELLSRLLVPDPEQRISMSEIKMIPWFRKNFTPSVAFSIDETI 294
>CE17429 [T] KOG0194 Protein tyrosine kinase
Length = 445
Score = 118 bits (295), Expect = 4e-26
Identities = 76/255 (29%), Positives = 130/255 (50%), Gaps = 13/255 (5%)
Query: 5 IAHGTYALKQVIGRGAYGVVYRAVKRGTNKPCAIKQIEFE--DESELNEHMLEIDLLKNL 62
+ H K+ IG GAYG VYR TN A+K+++ E DE L + M E +++
Sbjct: 172 LMHTDVNFKKQIGSGAYGTVYRGRLVKTNAIVAVKKLDTEGTDEEGLTDMMKEARVMQLY 231
Query: 63 RHQNIVEYRGFIQKAHELYIILEYCARGSLRDILKHGPLLE-DDTVNYVTQTLYGLQYLH 121
H NIV++ G+I ++LE+C GS+ D+L+ P ++ + V Y G+ YLH
Sbjct: 232 DHPNIVKFYGYILDDVPYLLVLEFCNGGSVEDLLRDKPEIKINRRVQYTYMAACGMDYLH 291
Query: 122 EQGVIHRDIKAANLLLTEEGIVKLADFGV--STRINRMAMTYAGSPNWMAPEVMTGQGAS 179
++ IHRDI + N L+ G+VK+ADFG+ +T + ++ ++ + W+APEV T
Sbjct: 292 KKNCIHRDIASRNCLI-HNGVVKMADFGMCRATAVYKVDLSKPLNVRWLAPEVWTNGETR 350
Query: 180 TVSDIWSLGATVVELLTGNPPFHNLVNESACYAIVNE-----EYIPPLTLSAECKDFLSR 234
+D+++ G + E P+ + E Y + + PP + + L+
Sbjct: 351 YNTDVYAFGVMIWEFFI--TPYQSPYTEWKGYTVKQKVRGGYRMQPPEGMPKDVASLLAE 408
Query: 235 CFQKNMFKRATAQEL 249
C+ + KR A++L
Sbjct: 409 CWNHDPEKRPNAEKL 423
>At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 594
Score = 118 bits (295), Expect = 4e-26
Identities = 86/268 (32%), Positives = 138/268 (51%), Gaps = 21/268 (7%)
Query: 8 GTYALKQVIGRGAYG-VVYRAVKRGTNK--PCAIKQI---EFEDESELNEHMLEIDLLKN 61
G Y L + +GRG +G + K+G K A+K I + + + E+ LLK
Sbjct: 140 GKYELGREVGRGHFGHTCWAKAKKGKIKGQTVAVKIISKSKMTSALSIEDVRREVKLLKA 199
Query: 62 LR-HQNIVEYRGFIQKAHELYIILEYCARGSLRD--ILKHGPLLEDDTVNYVTQTLYGLQ 118
L H ++V++ + + +++++E C G L D + + G E + + Q L
Sbjct: 200 LSGHSHMVKFYDVFEDSDNVFVVMELCEGGELLDSILARGGRYPEAEAKRILVQILSATA 259
Query: 119 YLHEQGVIHRDIKAANLLLT---EEGIVKLADFGVS--TRINRMAMTYAGSPNWMAPEVM 173
+ H QGV+HRD+K N L T E+ ++K+ DFG+S R ++ GS ++APEV+
Sbjct: 260 FFHLQGVVHRDLKPENFLFTSKNEDAVLKVIDFGLSDYARFDQRLNDVVGSAYYVAPEVL 319
Query: 174 TGQGASTVSDIWSLGATVVELLTGNPPFHNLVNESACYAIV-----NEEYIPPLTLSAEC 228
+ ST +DIWS+G LL G+ PF+ ESA + V N + +P ++S
Sbjct: 320 H-RSYSTEADIWSIGVISYILLCGSRPFYGRT-ESAIFRCVLRANPNFDDLPWPSISPIA 377
Query: 229 KDFLSRCFQKNMFKRATAQELLAHIWLK 256
KDF+ R K+ KR TA + LAH WL+
Sbjct: 378 KDFVKRLLNKDHRKRMTAAQALAHPWLR 405
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,695,207
Number of Sequences: 60738
Number of extensions: 2077377
Number of successful extensions: 11494
Number of sequences better than 1.0e-05: 1832
Number of HSP's better than 0.0 without gapping: 451
Number of HSP's successfully gapped in prelim test: 1381
Number of HSP's that attempted gapping in prelim test: 6383
Number of HSP's gapped (non-prelim): 2215
length of query: 797
length of database: 30,389,216
effective HSP length: 114
effective length of query: 683
effective length of database: 23,465,084
effective search space: 16026652372
effective search space used: 16026652372
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)