ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1094 check: MH D KOG0591 Cell cycle control, cell division, chromosome partitioning NIMA (never in mitosis)-related G2-specific serine/threonine protein kinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1094 386815 387996 394
(394 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YAR018c [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 451 e-127
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 236 4e-62
Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 234 1e-61
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 194 1e-49
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 171 1e-42
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 169 9e-42
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 160 4e-39
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 151 2e-36
At3g20860 [R] KOG0589 Serine/threonine protein kinase 149 7e-36
7301213 [R] KOG0589 Serine/threonine protein kinase 148 2e-35
CE23001 [R] KOG0589 Serine/threonine protein kinase 142 9e-34
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 142 1e-33
At1g54510 [R] KOG0589 Serine/threonine protein kinase 139 7e-33
At5g28290 [R] KOG0589 Serine/threonine protein kinase 138 1e-32
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 137 2e-32
At3g04810 [R] KOG0589 Serine/threonine protein kinase 137 4e-32
CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 134 2e-31
At3g44200 [R] KOG0589 Serine/threonine protein kinase 129 8e-30
CE15235 [R] KOG0589 Serine/threonine protein kinase 125 1e-28
CE27894_1 [R] KOG0589 Serine/threonine protein kinase 124 3e-28
YGL180w [OUT] KOG0595 Serine/threonine-protein kinase involved i... 120 5e-27
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 117 3e-26
SPCC63.08c [OUT] KOG0595 Serine/threonine-protein kinase involve... 114 2e-25
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 113 6e-25
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 112 7e-25
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 112 7e-25
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 112 1e-24
Hs7706286 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase E... 110 3e-24
7293666 [D] KOG0575 Polo-like serine/threonine protein kinase 110 3e-24
Hs14141724 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 109 8e-24
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 109 8e-24
Hs20127418 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 108 1e-23
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 108 1e-23
At3g12200 [R] KOG0589 Serine/threonine protein kinase 108 2e-23
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 107 2e-23
7302464 [R] KOG0586 Serine/threonine protein kinase 107 2e-23
7299438 [R] KOG0586 Serine/threonine protein kinase 107 2e-23
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 107 4e-23
ECU11g1500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 107 4e-23
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 105 1e-22
7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 105 1e-22
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 104 3e-22
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 104 3e-22
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 104 3e-22
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 104 3e-22
7304358 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 103 4e-22
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 103 4e-22
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 103 6e-22
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 103 6e-22
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 103 6e-22
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 103 6e-22
YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 102 1e-21
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 102 1e-21
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 102 1e-21
Hs21361133 [R] KOG0586 Serine/threonine protein kinase 102 1e-21
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 101 2e-21
At3g18750 [R] KOG0584 Serine/threonine protein kinase 100 3e-21
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 100 4e-21
At5g39440 [T] KOG0583 Serine/threonine protein kinase 100 4e-21
CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE28051 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 100 5e-21
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 100 5e-21
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 100 6e-21
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 100 6e-21
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 100 6e-21
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 100 6e-21
Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase 100 6e-21
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 99 8e-21
7290249 [R] KOG0586 Serine/threonine protein kinase 99 8e-21
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 99 1e-20
7299437 [R] KOG0586 Serine/threonine protein kinase 99 1e-20
Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase 99 1e-20
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 99 1e-20
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 98 2e-20
CE03080 [R] KOG0584 Serine/threonine protein kinase 98 2e-20
At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involv... 98 2e-20
Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase 98 2e-20
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 98 2e-20
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 98 2e-20
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 98 2e-20
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 98 2e-20
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 98 2e-20
CE28218 [D] KOG0588 Serine/threonine protein kinase 97 3e-20
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 97 3e-20
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 97 4e-20
HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase 97 5e-20
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 97 5e-20
CE27768 [R] KOG0586 Serine/threonine protein kinase 97 5e-20
CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase 97 5e-20
CE23838 [R] KOG0586 Serine/threonine protein kinase 97 5e-20
At4g08480 [T] KOG0198 MEKK and related serine/threonine protein ... 97 5e-20
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 97 5e-20
SPAC23A1.06c [T] KOG0032 Ca2+/calmodulin-dependent protein kinas... 96 9e-20
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 95 2e-19
At3g01090 [T] KOG0583 Serine/threonine protein kinase 95 2e-19
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 95 2e-19
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 95 2e-19
7290150 [T] KOG0583 Serine/threonine protein kinase 95 2e-19
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 94 3e-19
CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase 94 3e-19
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 94 3e-19
At3g29160 [T] KOG0583 Serine/threonine protein kinase 94 3e-19
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 94 3e-19
7294217 [D] KOG0588 Serine/threonine protein kinase 94 3e-19
Hs14754789 [OUT] KOG0595 Serine/threonine-protein kinase involve... 94 4e-19
CE28643 [T] KOG0583 Serine/threonine protein kinase 94 4e-19
CE07458 [T] KOG0583 Serine/threonine protein kinase 94 4e-19
7302570 [R] KOG0586 Serine/threonine protein kinase 94 4e-19
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 94 4e-19
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 94 5e-19
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 93 6e-19
YDR523c [T] KOG0201 Serine/threonine protein kinase 93 6e-19
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 93 6e-19
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 93 6e-19
ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase 93 6e-19
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 93 6e-19
SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 93 8e-19
Hs4502567_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase... 93 8e-19
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 1e-18
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 92 1e-18
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 92 1e-18
Hs14770402 [R] KOG0586 Serine/threonine protein kinase 92 1e-18
CE29318 [T] KOG0660 Mitogen-activated protein kinase 92 1e-18
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 92 1e-18
At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 2e-18
YKL101w [D] KOG0588 Serine/threonine protein kinase 91 2e-18
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 91 2e-18
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 91 2e-18
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 91 2e-18
YDR507c [D] KOG0588 Serine/threonine protein kinase 91 3e-18
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 91 3e-18
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 91 3e-18
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 91 3e-18
At5g41990 [R] KOG0584 Serine/threonine protein kinase 91 3e-18
At4g08470 [T] KOG0198 MEKK and related serine/threonine protein ... 91 3e-18
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 91 4e-18
CE27297 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 91 4e-18
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 91 4e-18
YHR102w [T] KOG0201 Serine/threonine protein kinase 90 5e-18
YCL024w [T] KOG0583 Serine/threonine protein kinase 90 5e-18
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 90 5e-18
Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE 90 5e-18
Hs20545357 [T] KOG0583 Serine/threonine protein kinase 90 5e-18
CE20258 [R] KOG0593 Predicted protein kinase KKIAMRE 90 5e-18
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 90 5e-18
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 90 7e-18
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 90 7e-18
CE16081 [T] KOG0583 Serine/threonine protein kinase 90 7e-18
CE00847 [T] KOG0583 Serine/threonine protein kinase 90 7e-18
At2g26980 [T] KOG0583 Serine/threonine protein kinase 90 7e-18
At1g29230 [T] KOG0583 Serine/threonine protein kinase 90 7e-18
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 89 9e-18
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 89 9e-18
CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase 89 9e-18
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 89 1e-17
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 89 1e-17
CE18009 [R] KOG0594 Protein kinase PCTAIRE and related kinases 89 1e-17
At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GT... 89 1e-17
At2g45490 [D] KOG0580 Serine/threonine protein kinase 89 1e-17
At1g49160 [R] KOG0584 Serine/threonine protein kinase 89 1e-17
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 89 1e-17
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 89 1e-17
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 89 1e-17
CE28251 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 89 1e-17
7302861 [T] KOG0696 Serine/threonine protein kinase 89 1e-17
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 89 1e-17
SPCC1322.08 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 88 2e-17
CE21025 [D] KOG0580 Serine/threonine protein kinase 88 2e-17
CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 88 2e-17
At2g25090 [T] KOG0583 Serine/threonine protein kinase 88 2e-17
7299793 [T] KOG0583 Serine/threonine protein kinase 88 2e-17
7297776 [D] KOG0580 Serine/threonine protein kinase 88 2e-17
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 88 3e-17
7293601 [T] KOG0577 Serine/threonine protein kinase 88 3e-17
YFR014c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 87 3e-17
Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 87 3e-17
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 87 4e-17
CE21213 [UT] KOG0662 Cyclin-dependent kinase CDK5 87 4e-17
CE09360 [Z] KOG0613 Projectin/twitchin and related proteins 87 4e-17
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 87 6e-17
YDR477w [T] KOG0583 Serine/threonine protein kinase 87 6e-17
7300224 [T] KOG0201 Serine/threonine protein kinase 87 6e-17
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 87 6e-17
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 86 7e-17
SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase 86 7e-17
Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 86 7e-17
ECU08g1920 [R] KOG0594 Protein kinase PCTAIRE and related kinases 86 7e-17
CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 86 7e-17
CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases 86 7e-17
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 86 7e-17
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 86 7e-17
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 86 1e-16
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 86 1e-16
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 86 1e-16
7300559 [T] KOG4279 Serine/threonine protein kinase 86 1e-16
7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 86 1e-16
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 86 1e-16
Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 86 1e-16
SPCC24B10.07 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 86 1e-16
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 86 1e-16
Hs13376175 [R] KOG0589 Serine/threonine protein kinase 86 1e-16
At5g25110 [T] KOG0583 Serine/threonine protein kinase 86 1e-16
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 86 1e-16
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 85 2e-16
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 85 2e-16
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 85 2e-16
Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PK... 85 2e-16
At3g10540 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 85 2e-16
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 85 2e-16
At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GT... 85 2e-16
At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protei... 85 2e-16
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 85 2e-16
7297680 [R] KOG0594 Protein kinase PCTAIRE and related kinases 85 2e-16
YGL158w [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 84 3e-16
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 84 3e-16
CE28674 [T] KOG0201 Serine/threonine protein kinase 84 3e-16
CE07510 [T] KOG0201 Serine/threonine protein kinase 84 3e-16
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 84 3e-16
At3g20410 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 84 3e-16
7299536 [D] KOG0580 Serine/threonine protein kinase 84 3e-16
Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 84 4e-16
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 84 4e-16
Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (... 84 4e-16
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 84 4e-16
At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GT... 84 4e-16
At4g18700 [T] KOG0583 Serine/threonine protein kinase 84 4e-16
At3g53930 [OUT] KOG0595 Serine/threonine-protein kinase involved... 84 4e-16
Hs4826675 [UT] KOG0662 Cyclin-dependent kinase CDK5 84 5e-16
Hs16418343 [T] KOG0583 Serine/threonine protein kinase 84 5e-16
Hs15277312 [R] KOG0584 Serine/threonine protein kinase 84 5e-16
At5g35410 [T] KOG0583 Serine/threonine protein kinase 84 5e-16
At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 84 5e-16
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 84 5e-16
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 84 5e-16
YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 83 6e-16
YBR160w [R] KOG0594 Protein kinase PCTAIRE and related kinases 83 6e-16
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 83 6e-16
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 83 6e-16
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 83 6e-16
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 83 6e-16
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 83 6e-16
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 83 6e-16
CE17284 [T] KOG0583 Serine/threonine protein kinase 83 6e-16
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 83 6e-16
At1g01140 [T] KOG0583 Serine/threonine protein kinase 83 6e-16
7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 83 6e-16
SPAC890.03 [T] KOG0583 Serine/threonine protein kinase 83 8e-16
Hs5032091 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 83 8e-16
Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases 83 8e-16
CE28571 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 83 8e-16
CE24761 [D] KOG0580 Serine/threonine protein kinase 83 8e-16
At1g50700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 83 8e-16
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 82 1e-15
ECU11g0180 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 82 1e-15
ECU08g0230 [R] KOG0594 Protein kinase PCTAIRE and related kinases 82 1e-15
7298087 [T] KOG0660 Mitogen-activated protein kinase 82 1e-15
Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE 82 1e-15
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 82 1e-15
CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 82 1e-15
CE01405 [T] KOG0577 Serine/threonine protein kinase 82 1e-15
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 82 1e-15
At5g55560 [R] KOG0584 Serine/threonine protein kinase 82 1e-15
At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 82 1e-15
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 82 2e-15
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 82 2e-15
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 82 2e-15
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 82 2e-15
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 82 2e-15
Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases 82 2e-15
CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 82 2e-15
CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 82 2e-15
7292592 [T] KOG1095 Protein tyrosine kinase 82 2e-15
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 81 2e-15
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 81 2e-15
Hs22055520 [R] KOG0584 Serine/threonine protein kinase 81 2e-15
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 81 2e-15
Hs14670383 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 81 2e-15
CE17354 [T] KOG0694 Serine/threonine protein kinase 81 2e-15
CE17353 [T] KOG0694 Serine/threonine protein kinase 81 2e-15
At2g38910 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 81 2e-15
At1g07150 [T] KOG0198 MEKK and related serine/threonine protein ... 81 2e-15
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 81 3e-15
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 81 3e-15
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 81 3e-15
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 81 3e-15
At5g07070 [T] KOG0583 Serine/threonine protein kinase 81 3e-15
At2g25880 [D] KOG0580 Serine/threonine protein kinase 81 3e-15
At1g76540 [R] KOG0594 Protein kinase PCTAIRE and related kinases 81 3e-15
7301971 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 81 3e-15
7300650 [R] KOG0594 Protein kinase PCTAIRE and related kinases 81 3e-15
At1g64630_2 [R] KOG0584 Serine/threonine protein kinase 81 3e-15
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 80 4e-15
Hs21361643 [T] KOG4717 Serine/threonine protein kinase 80 4e-15
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 80 4e-15
At5g10930 [T] KOG0583 Serine/threonine protein kinase 80 4e-15
At3g48750 [R] KOG0594 Protein kinase PCTAIRE and related kinases 80 4e-15
At1g12580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 80 4e-15
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 80 4e-15
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 80 5e-15
Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 80 5e-15
Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 80 5e-15
CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 80 5e-15
At5g58350 [R] KOG0584 Serine/threonine protein kinase 80 5e-15
At1g30270 [T] KOG0583 Serine/threonine protein kinase 80 5e-15
7303051 [UT] KOG0662 Cyclin-dependent kinase CDK5 80 5e-15
7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 80 5e-15
SPBC36B7.09 [J] KOG1035 eIF-2alpha kinase GCN2 80 7e-15
SPBC32C12.03c [T] KOG0583 Serine/threonine protein kinase 80 7e-15
Hs4557439 [R] KOG0594 Protein kinase PCTAIRE and related kinases 80 7e-15
Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) ki... 80 7e-15
Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 80 7e-15
Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 80 7e-15
Hs16160923 [R] KOG0594 Protein kinase PCTAIRE and related kinases 80 7e-15
Hs14749517 [T] KOG0192 Tyrosine kinase specific for activated (G... 80 7e-15
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 80 7e-15
At3g45640 [T] KOG0660 Mitogen-activated protein kinase 80 7e-15
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 80 7e-15
CE14884_1 [D] KOG0601 Cyclin-dependent kinase WEE1 80 7e-15
Hs6005850 [D] KOG0615 Serine/threonine protein kinase Chk2 and r... 79 9e-15
Hs4507719 [D] KOG0596 Dual specificity; serine/threonine and tyr... 79 9e-15
Hs20547712 [D] KOG0596 Dual specificity; serine/threonine and ty... 79 9e-15
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 79 9e-15
At5g67080 [T] KOG0198 MEKK and related serine/threonine protein ... 79 9e-15
At5g01820 [T] KOG0583 Serine/threonine protein kinase 79 9e-15
At4g35310 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 79 9e-15
At4g24400 [T] KOG0583 Serine/threonine protein kinase 79 9e-15
At1g07880 [T] KOG0660 Mitogen-activated protein kinase 79 9e-15
7297578 [T] KOG0661 MAPK related serine/threonine protein kinase 79 9e-15
YPL209c [D] KOG0580 Serine/threonine protein kinase 79 1e-14
Hs5453860 [R] KOG0594 Protein kinase PCTAIRE and related kinases 79 1e-14
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 79 1e-14
Hs4759044 [T] KOG0612 Rho-associated coiled-coil containing prot... 79 1e-14
Hs20986501 [T] KOG0660 Mitogen-activated protein kinase 79 1e-14
Hs20986497 [T] KOG0660 Mitogen-activated protein kinase 79 1e-14
Hs20536595 [T] KOG0612 Rho-associated coiled-coil containing pro... 79 1e-14
Hs15011928 [R] KOG0594 Protein kinase PCTAIRE and related kinases 79 1e-14
Hs13430860 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 79 1e-14
CE08727 [G] KOG0658 Glycogen synthase kinase-3 79 1e-14
At4g32830 [D] KOG0580 Serine/threonine protein kinase 79 1e-14
At3g22420 [R] KOG0584 Serine/threonine protein kinase 79 1e-14
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 79 1e-14
At1g61950 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 79 1e-14
YBR028c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 79 2e-14
SPAC23H4.02 [T] KOG0583 Serine/threonine protein kinase 79 2e-14
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 79 2e-14
Hs4758194 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 79 2e-14
Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 79 2e-14
CE28918 [R] KOG0594 Protein kinase PCTAIRE and related kinases 79 2e-14
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 79 2e-14
CE08098 [T] KOG0612 Rho-associated coiled-coil containing protei... 79 2e-14
At5g45810 [T] KOG0583 Serine/threonine protein kinase 79 2e-14
At3g63280 [R] KOG0589 Serine/threonine protein kinase 79 2e-14
At1g09600 [D] KOG0600 Cdc2-related protein kinase 79 2e-14
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 78 2e-14
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 78 2e-14
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 78 2e-14
CE18608 [R] KOG0594 Protein kinase PCTAIRE and related kinases 78 2e-14
At5g20930 [T] KOG1151 Tousled-like protein kinase 78 2e-14
At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 78 2e-14
Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 78 3e-14
Hs4505649 [R] KOG0594 Protein kinase PCTAIRE and related kinases 78 3e-14
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 78 3e-14
CE29073 [R] KOG0594 Protein kinase PCTAIRE and related kinases 78 3e-14
CE06779 [R] KOG0594 Protein kinase PCTAIRE and related kinases 78 3e-14
At3g04910 [R] KOG0584 Serine/threonine protein kinase 78 3e-14
At2g31500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 78 3e-14
At1g20930 [R] KOG0594 Protein kinase PCTAIRE and related kinases 78 3e-14
7293249 [T] KOG0612 Rho-associated coiled-coil containing protei... 78 3e-14
SPAC644.06c [D] KOG0588 Serine/threonine protein kinase 77 3e-14
Hs7662388 [T] KOG0661 MAPK related serine/threonine protein kinase 77 3e-14
Hs4758078 [T] KOG0197 Tyrosine kinases 77 3e-14
CE29020 [T] KOG0660 Mitogen-activated protein kinase 77 3e-14
CE17062 [T] KOG0660 Mitogen-activated protein kinase 77 3e-14
CE04430 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 77 3e-14
At4g01370 [T] KOG0660 Mitogen-activated protein kinase 77 3e-14
7300778 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 77 3e-14
7295431 [D] KOG0601 Cyclin-dependent kinase WEE1 77 3e-14
YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 77 4e-14
Hs4885583 [T] KOG0612 Rho-associated coiled-coil containing prot... 77 4e-14
Hs4505831 [T] KOG0612 Rho-associated coiled-coil containing prot... 77 4e-14
Hs4502743 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymera... 77 4e-14
CE25585 [T] KOG0193 Serine/threonine protein kinase RAF 77 4e-14
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 77 4e-14
At2g30360 [T] KOG0583 Serine/threonine protein kinase 77 4e-14
At1g18890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 77 4e-14
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 4e-14
At1g08720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 4e-14
Hs14042947 [T] KOG0583 Serine/threonine protein kinase 77 6e-14
CE24971 [T] KOG0660 Mitogen-activated protein kinase 77 6e-14
CE01583 [T] KOG0660 Mitogen-activated protein kinase 77 6e-14
At3g01490 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 6e-14
At2g34180 [T] KOG0583 Serine/threonine protein kinase 77 6e-14
At2g17290 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 77 6e-14
7291976 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 77 6e-14
YMR139w [G] KOG0658 Glycogen synthase kinase-3 76 8e-14
SPBC18H10.15 [R] KOG0663 Protein kinase PITSLRE and related kinases 76 8e-14
Hs20538863 [T] KOG4250 TANK binding protein kinase TBK1 76 8e-14
CE28650 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 76 8e-14
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 76 8e-14
At5g19360 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 76 8e-14
At5g04870 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 76 8e-14
At4g13020 [T] KOG0661 MAPK related serine/threonine protein kinase 76 8e-14
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 76 8e-14
At1g66750 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymera... 76 8e-14
7296128 [T] KOG0583 Serine/threonine protein kinase 76 8e-14
YGR040w [T] KOG0660 Mitogen-activated protein kinase 76 1e-13
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 76 1e-13
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 76 1e-13
Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE 76 1e-13
CE02377 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 76 1e-13
At5g12180 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 76 1e-13
At1g59580 [T] KOG0660 Mitogen-activated protein kinase 76 1e-13
At1g33770 [D] KOG0600 Cdc2-related protein kinase 76 1e-13
At1g10210 [T] KOG0660 Mitogen-activated protein kinase 76 1e-13
YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases 75 1e-13
YJL106w [T] KOG0661 MAPK related serine/threonine protein kinase 75 1e-13
Hs7705551 [T] KOG0661 MAPK related serine/threonine protein kinase 75 1e-13
Hs4557377 [T] KOG0197 Tyrosine kinases 75 1e-13
At5g58380 [T] KOG0583 Serine/threonine protein kinase 75 1e-13
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 75 1e-13
At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 75 1e-13
At2g35890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 75 1e-13
At1g76040 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 75 1e-13
At1g48490 [TR] KOG0606 Microtubule-associated serine/threonine k... 75 1e-13
YMR104c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 75 2e-13
YDL101c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 75 2e-13
At5g45430 [T] KOG0661 MAPK related serine/threonine protein kinase 75 2e-13
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 75 2e-13
Hs4507917 [D] KOG0601 Cyclin-dependent kinase WEE1 75 2e-13
CE27410 [T] KOG0583 Serine/threonine protein kinase 75 2e-13
CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 75 2e-13
CE12408 [T] KOG0661 MAPK related serine/threonine protein kinase 75 2e-13
At4g23650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 75 2e-13
At3g10660 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 75 2e-13
HsM4505263 [T] KOG0192 Tyrosine kinase specific for activated (G... 74 3e-13
Hs4826776 [T] KOG0197 Tyrosine kinases 74 3e-13
Hs21735550 [T] KOG0192 Tyrosine kinase specific for activated (G... 74 3e-13
At2g38620 [R] KOG0594 Protein kinase PCTAIRE and related kinases 74 3e-13
At1g71530 [D] KOG0600 Cdc2-related protein kinase 74 3e-13
7304311 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 74 3e-13
Hs22057171 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 74 4e-13
Hs20986531 [T] KOG0660 Mitogen-activated protein kinase 74 4e-13
Hs20986529 [T] KOG0660 Mitogen-activated protein kinase 74 4e-13
Hs20562757 [T] KOG0660 Mitogen-activated protein kinase 74 4e-13
Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 74 4e-13
CE21239 [T] KOG0583 Serine/threonine protein kinase 74 4e-13
CE20167 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 74 4e-13
At5g39420 [D] KOG0600 Cdc2-related protein kinase 74 4e-13
At4g38230 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 74 4e-13
At3g46930 [T] KOG0192 Tyrosine kinase specific for activated (GT... 74 4e-13
At2g43790 [T] KOG0660 Mitogen-activated protein kinase 74 4e-13
7299480 [T] KOG0197 Tyrosine kinases 74 4e-13
SPCC18B5.03 [D] KOG0601 Cyclin-dependent kinase WEE1 74 5e-13
SPBC8D2.19 [T] KOG0661 MAPK related serine/threonine protein kinase 74 5e-13
Hs4506401 [T] KOG0193 Serine/threonine protein kinase RAF 74 5e-13
Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 74 5e-13
Hs11496279 [T] KOG0661 MAPK related serine/threonine protein kinase 74 5e-13
At4g10010 [D] KOG0600 Cdc2-related protein kinase 74 5e-13
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 74 5e-13
7301110 [T] KOG0660 Mitogen-activated protein kinase 74 5e-13
7297009 [R] KOG0593 Predicted protein kinase KKIAMRE 74 5e-13
YKL126w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 73 6e-13
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 73 6e-13
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 73 6e-13
Hs4506071 [T] KOG0695 Serine/threonine protein kinase 73 6e-13
CE18454 [T] KOG4717 Serine/threonine protein kinase 73 6e-13
At5g50860 [D] KOG0600 Cdc2-related protein kinase 73 6e-13
At5g19450 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 73 6e-13
At4g22940 [D] KOG0600 Cdc2-related protein kinase 73 6e-13
At3g57530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 73 6e-13
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 73 6e-13
At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 73 6e-13
At2g18170 [T] KOG0660 Mitogen-activated protein kinase 73 6e-13
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 73 6e-13
7298698 [T] KOG4250 TANK binding protein kinase TBK1 73 6e-13
YLR096w [T] KOG0583 Serine/threonine protein kinase 73 8e-13
Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 73 8e-13
Hs11386209 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 73 8e-13
CE29453 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 73 8e-13
CE18366 [T] KOG0583 Serine/threonine protein kinase 73 8e-13
CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 73 8e-13
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 73 8e-13
At3g59410 [J] KOG1035 eIF-2alpha kinase GCN2 73 8e-13
At2g41860 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 73 8e-13
At1g03740 [D] KOG0600 Cdc2-related protein kinase 73 8e-13
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 72 1e-12
CE29612 [R] KOG0594 Protein kinase PCTAIRE and related kinases 72 1e-12
At5g63610 [K] KOG0666 Cyclin C-dependent kinase CDK8 72 1e-12
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 72 1e-12
Hs7661946 [T] KOG4250 TANK binding protein kinase TBK1 72 1e-12
CE02604 [T] KOG0695 Serine/threonine protein kinase 72 1e-12
At5g50000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 72 1e-12
>YAR018c [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 435
Score = 451 bits (1161), Expect = e-127
Identities = 220/382 (57%), Positives = 283/382 (73%), Gaps = 32/382 (8%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y++LEEIGRGSFGSVRKV+ K++VRK+++YGHMN+KERQQLI+EC+ILSQLKH+NI
Sbjct: 25 YQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENI 84
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
VEF++WD D + L+LYMEYCS+GDLSQMI++YK + KY+PE+ VW I+ Q+L AL+KC
Sbjct: 85 VEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYKQEHKYIPEKIVWGILAQLLTALYKC 144
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQN----------- 178
HYG +L L TIYD M+ P+K K +VIHRDLKPGNIFL+ D ++N N
Sbjct: 145 HYGVELPTLTTIYDRMKPPVKGKN-IVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNS 203
Query: 179 -------------ASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQ 225
S +DYS+V++KLGDFGLAKSL+ SI+FATTYVGTPYYMSPEVL DQ
Sbjct: 204 NYYRDHRVNSGKRGSPMDYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQ 263
Query: 226 PYSPLSDIWSLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRC 285
PYSPLSDIWSLGC+++E+CSLH PFQAK Y ELQ K+K G + +P +YS+ L II
Sbjct: 264 PYSPLSDIWSLGCVIFEMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSM 323
Query: 286 IQVDFTKRPSTWSLLNDIQCRICRKALDLEKFERHLLNYEHELTQVGEMLEQHATE---- 341
I V+ RPST+ LL DIQ R RK+L LE+FER LL+YE+ELT + ++LE+ A E
Sbjct: 324 IDVNLRTRPSTFELLQDIQIRTARKSLQLERFERKLLDYENELTNIEKILEKQAIEYERE 383
Query: 342 ---MKRDFASAVDQRVREILNG 360
+K F AV++R RE+++G
Sbjct: 384 LSQLKEQFTQAVEERAREVISG 405
>SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 722
Score = 236 bits (602), Expect = 4e-62
Identities = 134/361 (37%), Positives = 210/361 (58%), Gaps = 32/361 (8%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y++LE IG GSFG + KV R D ++ +KE+ +G++ +E+Q + E IL LKH NI
Sbjct: 4 YKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNI 63
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V++ + + + + LYMEYC GDL+ +I+ YK ++K E+ V + Q+L+AL++C
Sbjct: 64 VQYCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRC 123
Query: 130 HYGRDLSKLQTIYDA-MEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
HYG + + + + P +S V+HRD+KP NIFL DE N
Sbjct: 124 HYGENAPACDSQWPREIFHPKQS----VLHRDIKPANIFL----DENNS----------- 164
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KLGDFGL+K L + F +YVGTPYYMSPE++R PYS SD+W+LGC+++E+C L
Sbjct: 165 VKLGDFGLSKLLDNTRVFTQSYVGTPYYMSPEIIRSSPYSAKSDVWALGCVIFEICMLTH 224
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSL-----LNDI 303
PF+ ++Y ELQ + G H YS ++ +I C++V+ RP+T+ L L+DI
Sbjct: 225 PFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDI 284
Query: 304 QCRICRKALDLE------KFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQRVREI 357
+ ++ + + LE K + L+ E++L + L +E++ AS + QR EI
Sbjct: 285 RSKLESERVVLEQSDLLHKKHQMLIQLENDLQFREQRLSARESELENVIASRLAQR-EEI 343
Query: 358 L 358
L
Sbjct: 344 L 344
>Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 445
Score = 234 bits (598), Expect = 1e-61
Identities = 125/297 (42%), Positives = 173/297 (58%), Gaps = 32/297 (10%)
Query: 6 RQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLK 65
R Y +L IG GS+G +K+ R++D K++V KE+ YG M E+Q L+SE +L +LK
Sbjct: 4 RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK 63
Query: 66 HDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMA 125
H NIV ++ D + TL++ MEYC GDL+ +I +R+Y+ EE+V R+M Q+ +A
Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123
Query: 126 LFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYS 185
L +CH D G+ V+HRDLKP N+FL G
Sbjct: 124 LKECHRRSD-----------------GGHTVLHRDLKPANVFLDG--------------- 151
Query: 186 KVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCS 245
K +KLGDFGLA+ L FA T+VGTPYYMSPE + Y+ SDIWSLGC+LYELC+
Sbjct: 152 KQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCA 211
Query: 246 LHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
L PF A + EL GK++ G F +P+ YS L +IITR + + RPS +L +
Sbjct: 212 LMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILEN 268
>7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 735
Score = 194 bits (494), Expect = 1e-49
Identities = 97/285 (34%), Positives = 163/285 (57%), Gaps = 33/285 (11%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +L +G GSFG+ KV ++ ++ K + Y ++ + L+SE ++L QL+H NI
Sbjct: 19 YEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNI 78
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+++H + ++ ++++ ME C+ GDL+Q+++ + QR+ E Y+WR++ Q+ AL C
Sbjct: 79 VQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQRQRFEEPYIWRVLFQLCRALQVC 138
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H K ++HRD+KP NIFL +
Sbjct: 139 HN------------------KIPNGTILHRDIKPANIFLDAAGNA--------------- 165
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KLGDFGLA+ L+ FA ++VGTP+YMSPE+++ + Y SD+W++GC++YE+C+L P
Sbjct: 166 KLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPP 225
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRP 294
F+ + + +L K+ G F +P YS +LQ+II + VD +RP
Sbjct: 226 FRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRP 270
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 171 bits (434), Expect = 1e-42
Identities = 115/307 (37%), Positives = 158/307 (51%), Gaps = 43/307 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +L IG GSFG V E+ N++ KE+R + Q E +L+++KH NI
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHPNI 62
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V F +A+ + L++ MEYC GDL Q I+ K K PE+ + Q+ + +
Sbjct: 63 VAFKE-SFEAEGH-LYIVMEYCDGGDLMQKIKQQKG--KLFPEDMILNWFTQMCLGVNHI 118
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H R V+HRD+K NIFLT QN +
Sbjct: 119 HKKR----------------------VLHRDIKSKNIFLT-------QNGK--------V 141
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KLGDFG A+ L + FA TYVGTPYY+ PE+ + PY+ SDIWSLGCILYELC+L P
Sbjct: 142 KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHP 201
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN-DIQCRIC 308
FQA ++ L KV G PLP YS LQ ++ + + + + RPS +LL+ I R+
Sbjct: 202 FQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLV 261
Query: 309 RKALDLE 315
+K L E
Sbjct: 262 QKCLPPE 268
>Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 313
Score = 169 bits (427), Expect = 9e-42
Identities = 100/289 (34%), Positives = 151/289 (51%), Gaps = 43/289 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVR-YGHMNAKERQQLISECAILSQLKHDN 68
+++ ++IGRG F V K D K + K+V+ + M+AK RQ + E +L QL H N
Sbjct: 45 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 104
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I+++ D + N L + +E GDLSQMI+Y+K Q++ +PE VW+ VQ+ A+
Sbjct: 105 IIKYL--DSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEH 162
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H R V+HRD+KP N+F+T +
Sbjct: 163 MHSRR----------------------VMHRDIKPANVFITATG---------------V 185
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KLGD GL + + A + VGTPYYMSPE + + Y+ SDIWSLGC+LYE+ +L
Sbjct: 186 VKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQS 245
Query: 249 PFQAKTYT--ELQGKVKAGYFEPLP-HFYSKNLQDIITRCIQVDFTKRP 294
PF L K++ + PLP YS+ L+++++ CI D +RP
Sbjct: 246 PFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRP 294
>Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 302
Score = 160 bits (404), Expect = 4e-39
Identities = 97/289 (33%), Positives = 147/289 (50%), Gaps = 43/289 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVR-YGHMNAKERQQLISECAILSQLKHDN 68
+R+ ++IGRG F V + D + K+V+ + M+AK R I E +L QL H N
Sbjct: 34 FRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPN 93
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
+++++ + N L + +E GDLS+MI+++K Q++ +PE VW+ VQ+ AL
Sbjct: 94 VIKYYA--SFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEH 151
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H R V+HRD+KP N+F+T +
Sbjct: 152 MHSRR----------------------VMHRDIKPANVFITATG---------------V 174
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KLGD GL + + A + VGTPYYMSPE + + Y+ SDIWSLGC+LYE+ +L
Sbjct: 175 VKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQS 234
Query: 249 PFQAKTYT--ELQGKVKAGYFEPLP-HFYSKNLQDIITRCIQVDFTKRP 294
PF L K++ + PLP YS+ L+ ++ CI D KRP
Sbjct: 235 PFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRP 283
>Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase
Length = 292
Score = 151 bits (381), Expect = 2e-36
Identities = 96/291 (32%), Positives = 144/291 (48%), Gaps = 40/291 (13%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L +G+GS+G V V D K V K++ + +++ER+ E +LSQLKH NI
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + + L++ M +C GDL + ++ K Q +PE V VQI MAL
Sbjct: 66 VTYKE-SWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQ--LLPENQVVEWFVQIAMALQYL 122
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRDLK N+FLT + II
Sbjct: 123 HEKH----------------------ILHRDLKTQNVFLTRTN---------------II 145
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
K+GD G+A+ L+ + A+T +GTPYYMSPE+ ++PY+ SD+W+LGC +YE+ +L
Sbjct: 146 KVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHA 205
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
F AK L ++ G +P YS L ++I + +RPS S+L
Sbjct: 206 FNAKDMNSLVYRIIEGKLPAMPRDYSPELAELIRTMLSKRPEERPSVRSIL 256
>At3g20860 [R] KOG0589 Serine/threonine protein kinase
Length = 427
Score = 149 bits (376), Expect = 7e-36
Identities = 97/291 (33%), Positives = 150/291 (51%), Gaps = 42/291 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y ++E+IGRG+FGS V+ +++ + V K++R + + I E +++S+LK I
Sbjct: 15 YEVVEQIGRGAFGSAFLVIHKSERRKYVVKKIRLAKQTERCKLAAIQEMSLISKLKSPYI 74
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
VE+ D + + + + YC GD++QMI+ K + + EE + R MVQ+L+A+
Sbjct: 75 VEYK--DSWVEKDCVCIVTSYCEGGDMTQMIK--KSRGVFASEEKLCRWMVQLLLAIDYL 130
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H R V+HRDLK NIFLT ++ +
Sbjct: 131 HNNR----------------------VLHRDLKCSNIFLTKENE---------------V 153
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
+LGDFGLAK L + A++ VGTP YM PE+L D PY SDIWSLGC ++E+ +
Sbjct: 154 RLGDFGLAKLLGKD-DLASSMVGTPNYMCPELLADIPYGYKSDIWSLGCCMFEVAAHQPA 212
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
F+A L K+ PLP YS +L+ +I ++ + RP+ LL
Sbjct: 213 FKAPDMAALINKINRSSLSPLPVMYSSSLKRLIKSMLRKNPEHRPTAAELL 263
>7301213 [R] KOG0589 Serine/threonine protein kinase
Length = 841
Score = 148 bits (373), Expect = 2e-35
Identities = 91/291 (31%), Positives = 143/291 (48%), Gaps = 41/291 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +G+GSFG R++D +V K++ ++ R ++E + S+L H NI
Sbjct: 105 YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNI 164
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + K NTL + MEY G L+Q+I + + + PE Y+ + QI A+
Sbjct: 165 VSYL--GSFIKDNTLLIEMEYADGGTLAQIIAE-RQGKLHFPERYIIAVFEQISSAINYM 221
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRDLK N+FL + I+
Sbjct: 222 HSEN----------------------ILHRDLKTANVFLN---------------RRGIV 244
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
K+GDFG++K + I A T +GTPYY SPE+ + Y SDIW+LGCIL E+C L
Sbjct: 245 KIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKT 303
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
F A +EL K+ AG + P+P Y+ L+ +++ +QV+ +RP+ +L
Sbjct: 304 FAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL 354
>CE23001 [R] KOG0589 Serine/threonine protein kinase
Length = 579
Score = 142 bits (358), Expect = 9e-34
Identities = 87/291 (29%), Positives = 146/291 (49%), Gaps = 44/291 (15%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
Q Y + +G+G+FGS R D+ +++ KE+ +++ +R+ ++E ++LS+++H
Sbjct: 168 QNRYERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEH 227
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
NI+ ++ D + L + MEY G L+QM+ + + EE + +M+Q+ A+
Sbjct: 228 PNIIAYY--DSFEEEGVLMIEMEYADGGTLAQML---SRTQNLLDEEQIGDMMIQMCSAV 282
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
H V+HRDLK N+FLT D F
Sbjct: 283 AYLHENS----------------------VLHRDLKTANVFLTR--DSF----------- 307
Query: 187 VIIKLGDFGLAKSL--QASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELC 244
+K+GDFG++K + + + A T VGTPYY+SPE+ Y+ SD+W+LGCILYE+C
Sbjct: 308 --VKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMC 365
Query: 245 SLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
L F+ L + + P+ YS ++ +I +Q+D KRPS
Sbjct: 366 CLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPS 416
>Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase
Length = 330
Score = 142 bits (357), Expect = 1e-33
Identities = 98/306 (32%), Positives = 151/306 (49%), Gaps = 43/306 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +GRG+FG R D+ ++V KEV ++ KER+ ++E IL+ L+HDNI
Sbjct: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ +++ H + TL + +EYC+ G+L I + + K EE V + QI+ A+
Sbjct: 112 IAYYN--HFMDNTTLLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSCI 167
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRD+K NIFLT + +I
Sbjct: 168 HKAG----------------------ILHRDIKTLNIFLTKAN---------------LI 190
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KLGD+GLAK L + A T VGTPYYMSPE+ + Y+ SDIW++GC+++EL +L
Sbjct: 191 KLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRT 250
Query: 250 FQAKTYTELQGKVKAGY--FEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRI 307
F A L K+ G E YS L ++ C+ D +RP+ LL+ R
Sbjct: 251 FDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLLRK 310
Query: 308 CRKALD 313
R+ ++
Sbjct: 311 RRREME 316
>At1g54510 [R] KOG0589 Serine/threonine protein kinase
Length = 612
Score = 139 bits (350), Expect = 7e-33
Identities = 97/292 (33%), Positives = 141/292 (48%), Gaps = 43/292 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y LE+IG+GSFGS V + + K V K++R + R+ E ++S+++H I
Sbjct: 4 YEFLEQIGKGSFGSALLVRHKHEKKKYVLKKIRLARQTQRTRRSAHQEMELISKMRHPFI 63
Query: 70 VEFFH-WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
VE+ W K+ + + + YC GD++Q I+ K + EE + + +VQ+LM L
Sbjct: 64 VEYKDSWVE--KACYVCIVIGYCEGGDMAQAIK--KSNGVHFQEEKLCKWLVQLLMGLEY 119
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H ++HRD+K NIFLT D
Sbjct: 120 LHSNH----------------------ILHRDVKCSNIFLTKEQD--------------- 142
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
I+LGDFGLAK L S + ++ VGTP YM PE+L D PY SDIWSLGC +YE+ L
Sbjct: 143 IRLGDFGLAKIL-TSDDLTSSVVGTPSYMCPELLADIPYGSKSDIWSLGCCIYEMAYLKP 201
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
F+A L K+ PLP YS + ++ ++ + RPS LL
Sbjct: 202 AFKAFDMQALINKINKTIVSPLPAKYSGPFRGLVKSMLRKNPEVRPSASDLL 253
>At5g28290 [R] KOG0589 Serine/threonine protein kinase
Length = 568
Score = 138 bits (348), Expect = 1e-32
Identities = 103/321 (32%), Positives = 154/321 (47%), Gaps = 45/321 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +LE+IG+GSFGS V + + K+ V K++R + R+ E ++S++++ I
Sbjct: 4 YEVLEQIGKGSFGSALLVRHKHEKKLYVLKKIRLARQTGRTRRSAHQEMELISKIRNPFI 63
Query: 70 VEFFH-WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
VE+ W K + + + YC GD+++ I+ K EE + + +VQ+LMAL
Sbjct: 64 VEYKDSWVE--KGCYVCIVIGYCKGGDMAEAIK--KANGVEFSEEKLCKWLVQLLMALEY 119
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H ++HRD+K NIFLT D
Sbjct: 120 LHASH----------------------ILHRDVKCSNIFLTKDQD--------------- 142
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
I+LGDFGLAK L S + A++ VGTP YM PE+L D PY SDIWSLGC +YE+ +L
Sbjct: 143 IRLGDFGLAKIL-TSDDLASSVVGTPSYMCPELLADIPYGSKSDIWSLGCCMYEMTALKP 201
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND--IQCR 306
F+A L ++ PLP YS + ++ ++ + RPS LL +Q
Sbjct: 202 AFKAFDMQGLINRINRSIVAPLPAQYSTAFRSLVKSMLRKNPELRPSASDLLRQPLLQPY 261
Query: 307 ICRKALDLEKFERHLLNYEHE 327
+ + L L E L E E
Sbjct: 262 VQKVLLKLSFREHDTLPSESE 282
>Hs20547878 [R] KOG0589 Serine/threonine protein kinase
Length = 758
Score = 137 bits (346), Expect = 2e-32
Identities = 90/291 (30%), Positives = 142/291 (47%), Gaps = 64/291 (21%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +++ IG+G+FG ++D+K V KE+ + E+ Q+I
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINF------EKHQMIPFLT---------- 47
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
++ LF+ MEYC GDL M R + + E+ + VQI + L
Sbjct: 48 ----------ENGRLFIVMEYCDGGDL--MKRINRQRGVLFSEDQILGWFVQISLGLKHI 95
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + ++HRD+K NIFL+ + ++
Sbjct: 96 HDRK----------------------ILHRDIKAQNIFLSK--------------NGMVA 119
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KLGDFG+A+ L S+E A T +GTPYY+SPE+ +++PY+ +DIWSLGC+LYELC+L P
Sbjct: 120 KLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHP 179
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
F+ +L K+ +F P+ +S+ L +I++ QV RPS S+L
Sbjct: 180 FEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSIL 230
>At3g04810 [R] KOG0589 Serine/threonine protein kinase
Length = 606
Score = 137 bits (344), Expect = 4e-32
Identities = 95/292 (32%), Positives = 144/292 (48%), Gaps = 43/292 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +LE+IG+GSFGS V + + K+ V K++R + R+ E ++S++ + I
Sbjct: 4 YEVLEQIGKGSFGSALLVRHKHEKKLYVLKKIRLARQTGRTRRSAHQEMELISKIHNPFI 63
Query: 70 VEFFH-WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
VE+ W K + + + YC GD+++ I+ K + EE + + +VQIL+AL
Sbjct: 64 VEYKDSWVE--KGCYVCIIIGYCKGGDMAEAIK--KTNGVHFTEEKLCKWLVQILLALEY 119
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H ++HRD+K NIFLT D
Sbjct: 120 LHANH----------------------ILHRDVKCSNIFLTKDQD--------------- 142
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
I+LGDFGLAK L S + A++ VGTP YM PE+L D PY SDIWSLGC +YE+ ++
Sbjct: 143 IRLGDFGLAKVL-TSDDLASSVVGTPSYMCPELLADIPYGSKSDIWSLGCCMYEMTAMKP 201
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
F+A L ++ PLP YS + ++ ++ + RPS LL
Sbjct: 202 AFKAFDMQGLINRINRSIVPPLPAQYSAAFRGLVKSMLRKNPELRPSAAELL 253
>CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 294
Score = 134 bits (337), Expect = 2e-31
Identities = 82/261 (31%), Positives = 130/261 (49%), Gaps = 42/261 (16%)
Query: 14 EEIGRGSFGSV-RKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEF 72
++IG+G F V R D V ++K + ++ K RQ + E +L QL H N++ +
Sbjct: 27 KKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRY 86
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
+ D +N L + +E GD+S+MI+++K + +PE+ +W+ VQ+ AL H
Sbjct: 87 YASFID--NNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSK 144
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
R ++HRD+KP N+F+TG I+KLG
Sbjct: 145 R----------------------IMHRDIKPANVFITGNG---------------IVKLG 167
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQA 252
D GL + + A + VGTPYYMSPE +++ Y+ SD+WS GC+LYE+ +L PF
Sbjct: 168 DLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYG 227
Query: 253 KTYT--ELQGKVKAGYFEPLP 271
L K++ + PLP
Sbjct: 228 DKMNLYSLCKKIENCEYPPLP 248
>At3g44200 [R] KOG0589 Serine/threonine protein kinase
Length = 941
Score = 129 bits (324), Expect = 8e-30
Identities = 84/248 (33%), Positives = 127/248 (50%), Gaps = 43/248 (17%)
Query: 6 RQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLK 65
R Y L+E+IGRG+FG+ V +A+ K V K++R + R+ E +++++++
Sbjct: 4 RMDQYELMEQIGRGAFGAAILVHHKAERKKYVLKKIRLARQTERCRRSAHQEMSLIARVQ 63
Query: 66 HDNIVEFFH-WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
H IVEF W K + + YC GD++++++ K Y PEE + + Q+L+
Sbjct: 64 HPYIVEFKEAWVE--KGCYVCIVTGYCEGGDMAELMK--KSNGVYFPEEKLCKWFTQLLL 119
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
A+ H V+HRDLK NIFLT D
Sbjct: 120 AVEYLHSN----------------------YVLHRDLKCSNIFLTKDQD----------- 146
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELC 244
++LGDFGLAK+L+A + ++ VGTP YM PE+L D PY SDIWSLGC +YE+
Sbjct: 147 ----VRLGDFGLAKTLKAD-DLTSSVVGTPNYMCPELLADIPYGFKSDIWSLGCCIYEMA 201
Query: 245 SLHVPFQA 252
+ F+A
Sbjct: 202 AYRPAFKA 209
>CE15235 [R] KOG0589 Serine/threonine protein kinase
Length = 357
Score = 125 bits (314), Expect = 1e-28
Identities = 85/300 (28%), Positives = 139/300 (46%), Gaps = 46/300 (15%)
Query: 10 YRLLEEIGRGSFGS--VRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHD 67
Y + +GRG+FG + + +A ++ ++ K + M KE + SE +L +++H
Sbjct: 4 YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHP 63
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYK-----HQRKYVPEEYVWRIMVQI 122
I+ + D N L + M+Y G L ++I + + R+Y PE+ V QI
Sbjct: 64 LIIGYI--DSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQI 121
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
L+AL H ++HRDLKP NI +
Sbjct: 122 LIALNHMHQKN----------------------IVHRDLKPQNILM-------------- 145
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYE 242
+ K ++KL DFG++K L A+T +GTP Y+SPE+ +PY+ SD+WSLGC+LYE
Sbjct: 146 NRRKTVLKLSDFGISKELGTK-SAASTVIGTPNYLSPEICESRPYNQKSDMWSLGCVLYE 204
Query: 243 LCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
L L F + + K+ PL S +++ ++ ++ KRP LL+D
Sbjct: 205 LLQLERAFDGENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLSD 264
>CE27894_1 [R] KOG0589 Serine/threonine protein kinase
Length = 1011
Score = 124 bits (310), Expect = 3e-28
Identities = 88/296 (29%), Positives = 147/296 (48%), Gaps = 51/296 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN------KVMVRKEVRYGHMNAKERQQ----LISECA 59
Y LL+++G G+FG V V ++A + K++ KE+ ++N +E + +ISE
Sbjct: 431 YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKSFGDMISEVK 490
Query: 60 ILSQ-LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRI 118
I+ Q L+H NIV + +++ L++ M+ L +I K ++ E+ +W +
Sbjct: 491 IIKQQLRHPNIVRYRRIF--VENHRLYIVMDLIQGCSLRDLIITMKEKKGNFEEKKIWAM 548
Query: 119 MVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQN 178
+VQ+++AL H K ++HRDLKP NI +T DE
Sbjct: 549 VVQMMLALRYLH---------------------KEKQIVHRDLKPNNIMMT--TDE---- 581
Query: 179 ASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGC 238
+V+I DFGLAK Q E+ + GT Y PE++++ PY +DIWS GC
Sbjct: 582 -------RVVIT--DFGLAK--QKGPEYLKSAAGTIIYSCPEIVQNLPYGEKADIWSFGC 630
Query: 239 ILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRP 294
+YE+C L F + L ++ ++PL +S +L+ +IT C+ D + RP
Sbjct: 631 CIYEMCQLQPVFHSTNMLTLAMQIVEAKYDPLNEMWSDDLRFLITSCLAPDPSARP 686
>YGL180w [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 897
Score = 120 bits (300), Expect = 5e-27
Identities = 86/266 (32%), Positives = 143/266 (53%), Gaps = 21/266 (7%)
Query: 10 YRLLEEIGRGSFGSVRK--VVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHD 67
Y +EIG+GSF +V + + + V +++ R N K + L E AIL ++KH
Sbjct: 24 YTAEKEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHP 83
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
+IV D + S +L MEYC+ GDL+ ++ K +++ + + R + +
Sbjct: 84 HIVGLI--DCERTSTDFYLIMEYCALGDLTFLL---KRRKELMENHPLLRTVFEKYPPPS 138
Query: 128 KCHYGRD----LSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLT----GYDDE--FNQ 177
+ H G LS LQ + A++ L+SK ++HRD+KP N+ L+ GY D F++
Sbjct: 139 ENHNGLHRAFVLSYLQQLASALKF-LRSKN--LVHRDIKPQNLLLSTPLIGYHDSKSFHE 195
Query: 178 NASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLG 237
Y+ I+K+ DFG A+ L + A T G+P YM+PE+L Q Y+ +D+WS+G
Sbjct: 196 LGFVGIYNLPILKIADFGFARFLP-NTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVG 254
Query: 238 CILYELCSLHVPFQAKTYTELQGKVK 263
+++E+C PF+A + EL K+K
Sbjct: 255 TVVFEMCCGTPPFRASNHLELFKKIK 280
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 117 bits (293), Expect = 3e-26
Identities = 87/300 (29%), Positives = 145/300 (48%), Gaps = 48/300 (16%)
Query: 4 NERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQ 63
+E+ Y L + IGRGS+G V K + + ++V+ KEV Y N +E +++E ++L
Sbjct: 19 SEKSVQYHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYE--NDEELNDIMAEISLLKN 76
Query: 64 LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
L H+NIV++ + KS L++ +EYC+ G L ++I + E + Q L
Sbjct: 77 LNHNNIVKYHGFIR--KSYELYILLEYCANGSLRRLI---SRSSTGLSENESKTYVTQTL 131
Query: 124 MALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVD 183
+ L H G VIHRD+K NI L+ +
Sbjct: 132 LGLKYLH----------------------GEGVIHRDIKAANILLSADNT---------- 159
Query: 184 YSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
+KL DFG++ + +S A T GT +M+PE+L ++ S LSDIWSLG + E+
Sbjct: 160 -----VKLADFGVSTIVNSS---ALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEM 211
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDI 303
+ + P+ T + V+ + P P +S+ L+D +++C + KRP+ LL +
Sbjct: 212 LTKNPPYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHV 270
>SPCC63.08c [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 830
Score = 114 bits (286), Expect = 2e-25
Identities = 88/267 (32%), Positives = 133/267 (48%), Gaps = 19/267 (7%)
Query: 4 NERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQ 63
N+ Y + EIGRGSF V K N+V+ K V + K + L SE +IL +
Sbjct: 8 NQTIGPYVIRSEIGRGSFAIVYKGKHTETNRVISIKSVLTKKLTKKLLENLESEISILKE 67
Query: 64 LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
++H ++VE D + L MEYCS GDLS IR K ++ W +
Sbjct: 68 IRHVHVVELI--DCIKAGRFIHLVMEYCSLGDLSYFIR--KREKFNSIPSLAWINIDH-- 121
Query: 124 MALFKCHYGRDLSK--LQTIYDAMEEPLKSKGYVVIHRDLKPGNIFL-----TGYDDEFN 176
++K L + Q + A++ L+S+ +IHRD+KP N+ L Y +E
Sbjct: 122 PPVYKAGLNETLVRHFTQQLASALQF-LRSRS--LIHRDVKPQNLLLQPPPTAAYLEEHP 178
Query: 177 QNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSL 236
Q ++KL DFG A+ LQ S A T G+P YM+PE+LR + Y +D+WS+
Sbjct: 179 QFVGSPKLP--MLKLADFGFARYLQTS-SMAETLCGSPLYMAPEILRYEKYDAKADLWSV 235
Query: 237 GCILYELCSLHVPFQAKTYTELQGKVK 263
G +LYE+ PF+A + EL +++
Sbjct: 236 GAVLYEMAVGKPPFKAPNHVELLRRIQ 262
>YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 515
Score = 113 bits (282), Expect = 6e-25
Identities = 93/300 (31%), Positives = 144/300 (48%), Gaps = 42/300 (14%)
Query: 13 LEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLK-HDNIVE 71
L +IG G+ G+V K + D+K++ +K + N+ QL+ E +I+ +K H+NI+
Sbjct: 194 LGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIIT 253
Query: 72 FFHWDHDAK-SNTLFLYMEYCSKGDLSQMIRYYKH--QRKYVPEEYVWRIMVQILMALFK 128
F+ ++ +N + + MEY G L +++ YK QR V + W + I K
Sbjct: 254 FYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTIS----K 309
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
YG L+ L +Y + Y +IHRD+KP N+ + SK
Sbjct: 310 IAYGV-LNGLDHLY---------RQYKIIHRDIKPSNVLIN---------------SKGQ 344
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
IKL DFG++K L SI A T+VGT YMSPE ++ YS D+WSLG ++ EL +
Sbjct: 345 IKLCDFGVSKKLINSI--ADTFVGTSTYMSPERIQGNVYSIKGDVWSLGLMIIELVTGEF 402
Query: 249 PFQAKTYTE--LQGKVKAGYFEPLP-----HFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
P T + ++ EP P YSK + D + RC + +R S LL+
Sbjct: 403 PLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRCCIKNERERSSIHELLH 462
>Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1050
Score = 112 bits (281), Expect = 7e-25
Identities = 79/244 (32%), Positives = 122/244 (49%), Gaps = 35/244 (14%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHW 75
IG G+F V K + + V + AK + L E IL +LKH+NIV +
Sbjct: 22 IGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALY-- 79
Query: 76 DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDL 135
D +N+++L MEYC+ GDL+ Y H + + E+ + + QI A+ H
Sbjct: 80 DFQEMANSVYLVMEYCNGGDLAD----YLHAMRTLSEDTIRLFLQQIAGAMRLLH----- 130
Query: 136 SKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFG 195
SKG +IHRDLKP NI L+ N + + + +K+ DFG
Sbjct: 131 ---------------SKG--IIHRDLKPQNILLS------NPAGRRANPNSIRVKIADFG 167
Query: 196 LAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKTY 255
A+ LQ+++ A T G+P YM+PEV+ Q Y +D+WS+G I+Y+ + PFQA +
Sbjct: 168 FARYLQSNM-MAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSP 226
Query: 256 TELQ 259
+L+
Sbjct: 227 QDLR 230
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 112 bits (281), Expect = 7e-25
Identities = 78/249 (31%), Positives = 120/249 (47%), Gaps = 41/249 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L IG GSF V + + KE+ ++ K R L+ E +ILS + H NI
Sbjct: 10 YALGPRIGSGSFAVVWLAKHRSSGLEVAVKEIDKKLLSPKVRDNLLKEISILSTIDHPNI 69
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ F+ + + +FL +EYCS GDL+ I +H + VPE M Q+ + L
Sbjct: 70 IRFY--EAIETGDRIFLVLEYCSGGDLAGYIN--RHGK--VPEAVAKHFMRQLALGL--- 120
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
+ L+ K + IHRDLKP N+ L+ + ++
Sbjct: 121 -----------------QVLQEKHF--IHRDLKPQNLLLSSKE------------VTPLL 149
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
K+GDFG A+SL A T+ G+P YM+PE++R+Q Y +D+WS G IL++L + P
Sbjct: 150 KIGDFGFARSLTPE-SMAETFCGSPLYMAPEIIRNQKYDAKADLWSAGAILFQLVTGKPP 208
Query: 250 FQAKTYTEL 258
F + +L
Sbjct: 209 FDGNNHIQL 217
>7293496 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 805
Score = 112 bits (280), Expect = 1e-24
Identities = 80/254 (31%), Positives = 123/254 (47%), Gaps = 44/254 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +G+GSFG V K R+ D+KV+ K + KE + L EC I ++LKH ++
Sbjct: 4 YAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHV 63
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+E ++K++ LF+ E+ L + RY + + EE R+ ++ AL+
Sbjct: 64 IEMIE-SFESKTD-LFVVTEFA----LMDLHRYLSYNGA-MGEEPARRVTGHLVSALYYL 116
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H R ++HRDLKP N+ L + N +A
Sbjct: 117 HSNR----------------------ILHRDLKPQNVLL-----DKNMHA---------- 139
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFGLA+++ T+ GTP YM+PE+L +QPY +D+WSLGCI YE + P
Sbjct: 140 KLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQPP 199
Query: 250 FQAKTYTELQGKVK 263
F A + L +K
Sbjct: 200 FCASSILHLVKMIK 213
>Hs7706286 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 489
Score = 110 bits (276), Expect = 3e-24
Identities = 83/287 (28%), Positives = 131/287 (44%), Gaps = 43/287 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+L EE+G+G+F VR+ V+ + K + ++A++ Q+L E I LKH NI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V D ++ +L + + G+L + I R+Y E + QIL A+ C
Sbjct: 73 VRLH--DSISEEGHHYLIFDLVTGGELFEDIV----AREYYSEADASHCIQQILEAVLHC 126
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H V+HRDLKP N+ L +
Sbjct: 127 HQ----------------------MGVVHRDLKPENLLLAS------------KLKGAAV 152
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFGLA ++ + + GTP Y+SPEVLR PY D+W+ G ILY L + P
Sbjct: 153 KLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPP 212
Query: 250 FQAKTYTELQGKVKAGYFE-PLPHF--YSKNLQDIITRCIQVDFTKR 293
F + L ++KAG ++ P P + + +D+I + + ++ +KR
Sbjct: 213 FWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKR 259
>7293666 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 576
Score = 110 bits (276), Expect = 3e-24
Identities = 82/299 (27%), Positives = 137/299 (45%), Gaps = 46/299 (15%)
Query: 4 NERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHM-NAKERQQLISECAILS 62
N+R+ TY+ + G+G F +++ + V K V M ++++ E I
Sbjct: 20 NQRK-TYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHR 78
Query: 63 QLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
L H NIV+F ++ D S +++ +E C K + ++ + +RK + E
Sbjct: 79 SLNHPNIVKFHNYFED--SQNIYIVLELCKKRSMMELHK----RRKSITE---------- 122
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
F+C Y IY ++ +IHRDLK GN+FL
Sbjct: 123 ----FECRY--------YIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDL----------- 159
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYE 242
+ +K+GDFGLA ++ E T GTP Y++PE+L + +S DIWS+GC++Y
Sbjct: 160 ----LHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYT 215
Query: 243 LCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
L PF+ KT + K+K + +P + K D++ +Q + RP+ LLN
Sbjct: 216 LLVGQPPFETKTLKDTYSKIKKCEYR-VPSYLRKPAADMVIAMLQPNPESRPAIGQLLN 273
>Hs14141724 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 499
Score = 109 bits (272), Expect = 8e-24
Identities = 84/289 (29%), Positives = 132/289 (45%), Gaps = 47/289 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+L EE+G+G+F VR+ ++ + K + ++A++ Q+L E I LKH NI
Sbjct: 14 YQLFEELGKGAFSVVRRCMKIPTGQGYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 73
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ S F Y+ + + G+L + I R+Y E + QIL ++
Sbjct: 74 VRL----HDSISEEGFHYLVFDLVTGGELFEDIV----AREYYSEADASHCIQQILESVN 125
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH ++HRDLKP N+ L
Sbjct: 126 HCHLNG----------------------IVHRDLKPENLLLASKS------------KGA 151
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA +Q + + GTP Y+SPEVLR PY D+W+ G ILY L +
Sbjct: 152 AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGY 211
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF--YSKNLQDIITRCIQVDFTKR 293
PF + L ++KAG ++ P P + + +D+I + + ++ KR
Sbjct: 212 PPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKR 260
>At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 257
Score = 109 bits (272), Expect = 8e-24
Identities = 78/249 (31%), Positives = 116/249 (46%), Gaps = 41/249 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +IG GSF V + D + KE+ +N K ++ L+SE IL ++ H NI
Sbjct: 12 YLVGRQIGSGSFSVVWEARHRVDGTEVAIKEIAMDRLNKKLQESLMSEIFILRRINHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ D + L +EYC GDLS Y + VPE M Q+ L
Sbjct: 72 IRLI--DMIKSPGKVHLVLEYCKGGDLS----VYVQRHGIVPEATAKHFMQQLAAGL--- 122
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
Q + D +IHRDLKP N+ L+ N+N +D +
Sbjct: 123 ---------QVLRDNN----------IIHRDLKPQNLLLST-----NENDAD-------L 151
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
K+ DFG A+SLQ A T G+P YM+PE+++ Q Y +D+WS+G IL++L + P
Sbjct: 152 KIADFGFARSLQPR-GLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQLVTGRTP 210
Query: 250 FQAKTYTEL 258
F + +L
Sbjct: 211 FTGNSQIQL 219
>Hs20127418 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 664
Score = 108 bits (270), Expect = 1e-23
Identities = 86/289 (29%), Positives = 132/289 (44%), Gaps = 47/289 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+L E+IG+G+F VR+ V+ K + ++A++ Q+L E I LKH NI
Sbjct: 14 YQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNI 73
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ S F Y+ + + G+L + I R+Y E + QIL A+
Sbjct: 74 VRL----HDSISEEGFHYLVFDLVTGGELFEDIV----AREYYSEADASHCIQQILEAVL 125
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH V+HRDLKP N+ L
Sbjct: 126 HCHQ----------------------MGVVHRDLKPENLLLAS------------KCKGA 151
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA +Q + + GTP Y+SPEVLR + Y DIW+ G ILY L +
Sbjct: 152 AVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGY 211
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF--YSKNLQDIITRCIQVDFTKR 293
PF + +L ++KAG ++ P P + + +++I + + ++ KR
Sbjct: 212 PPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKR 260
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 108 bits (270), Expect = 1e-23
Identities = 88/325 (27%), Positives = 142/325 (43%), Gaps = 43/325 (13%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L +EIG+G++G V K + + + K+V ++ ++ ++ E +L L H NI
Sbjct: 20 YMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIVQEDLNTIMQEIDLLKNLNHKNI 79
Query: 70 VEFFHWDHDAKSNT-LFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
V++ +K+ T L + +EY G L+ +I+ K PE V + Q+L L
Sbjct: 80 VKYLG---SSKTKTHLHIILEYVENGSLANIIKPNKFGP--FPESLVAVYIAQVLEGLVY 134
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H +G VIHRD+K NI T + +
Sbjct: 135 LH--------------------EQG--VIHRDIKGANILTT---------------KEGL 157
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KL DFG+A L + + VGTPY+M+PEV+ SDIWS+GC + EL +
Sbjct: 158 VKLADFGVATKLNEADVNTHSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVP 217
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRIC 308
P+ ++ P+P S ++ D + +C + D +RP +LL+ R
Sbjct: 218 PYYDLQPMPALFRIVQDDNPPIPDSLSPDITDFLRQCFKKDSRQRPDAKTLLSHPWIRNS 277
Query: 309 RKALDLEKFERHLLNYEHELTQVGE 333
R+AL + Y E T E
Sbjct: 278 RRALQSSLRHSGTIKYMKEATASSE 302
>At3g12200 [R] KOG0589 Serine/threonine protein kinase
Length = 571
Score = 108 bits (269), Expect = 2e-23
Identities = 84/295 (28%), Positives = 133/295 (44%), Gaps = 45/295 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y ++E++ RG S V+ + ++K K++ K +Q + E +LS LK+ I
Sbjct: 19 YHVVEQVRRGKSSSDFVVLHDIEDKKYAMKKICLAKHTDKLKQTALQEMKLLSSLKNPYI 78
Query: 70 VEFFH-W-DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V + W D+D N ++ Y G+++ I+ K + K PEE +++ + Q+L+A+
Sbjct: 79 VHYEDSWIDND---NNACIFTAYYEGGNMANAIK--KARGKLFPEERIFKWLAQLLLAVN 133
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
H R V+H DL NIFL D
Sbjct: 134 YLHSNR----------------------VVHMDLTCSNIFLPKDDH-------------- 157
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
++LG++GLAK + + + G M PEVL DQPY SDIWSLGC +YE+ +
Sbjct: 158 -VQLGNYGLAKLINPE-KPVSMVSGISNSMCPEVLEDQPYGYKSDIWSLGCCMYEITAHQ 215
Query: 248 VPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
F+A L K+ PLP YS L+ +I ++ RP+ LL +
Sbjct: 216 PAFKAPDMAGLINKINRSLMSPLPIVYSSTLKQMIKLMLRKKPEYRPTACELLRN 270
>CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 856
Score = 107 bits (268), Expect = 2e-23
Identities = 87/299 (29%), Positives = 138/299 (46%), Gaps = 43/299 (14%)
Query: 10 YRLLEEIGRGSFGSVRK--VVREADNKVMVRKEVRYGHMNAKERQQLISECAIL---SQL 64
Y + +G G+F V + V D V ++ + +K + L E IL S L
Sbjct: 9 YSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNI--SKSKNLLTKEIKILKELSSL 66
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
KH+N+V ++L ME+C+ GDL+ Y Q+ + E+ + +VQI
Sbjct: 67 KHENLVGLLKCTETPTH--VYLVMEFCNGGDLAD----YLQQKTTLNEDTIQHFVVQIAH 120
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
AL E + KG ++HRDLKP NI L N + +
Sbjct: 121 AL--------------------EAINKKG--IVHRDLKPQNILLCN-----NSRTQNPHF 153
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELC 244
+ ++IKL DFG A+ L + A T G+P YM+PEV+ Y +D+WS+G IL++
Sbjct: 154 TDIVIKLADFGFARFLNDGV-MAATLCGSPMYMAPEVIMSMQYDAKADLWSIGTILFQCL 212
Query: 245 SLHVPFQAKTYTELQGKV-KAGYFEP-LPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
+ PF A+T +L+ K P +P + S NL+D++ R ++ + R S N
Sbjct: 213 TGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCSPNLRDLLLRLLKRNAKDRISFEDFFN 271
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 107 bits (268), Expect = 2e-23
Identities = 86/294 (29%), Positives = 134/294 (45%), Gaps = 46/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+L++ IG+G+F V+ K + K + +N Q+L E I+ L H NI
Sbjct: 151 YKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNI 210
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F K TL+L MEY S G++ + H R E V QI+ A+ C
Sbjct: 211 VKLFQVIETEK--TLYLIMEYASGGEVFDYL--VLHGRMKEKEARV--KFRQIVSAVQYC 264
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H R +IHRDLK N+ L D E N I
Sbjct: 265 HQKR----------------------IIHRDLKAENLLL---DSELN------------I 287
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLHV 248
K+ DFG + + T+ G+P Y +PE+ + + Y P D+WSLG ILY L S +
Sbjct: 288 KIADFGFSNEFTPGSKL-DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 346
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF T EL+ +V G + +P + S + ++++ + + ++ KR S +++ D
Sbjct: 347 PFDGSTLRELRERVLRGKYR-IPFYMSTDCENLLRKFLVLNPAKRASLETIMGD 399
>7299438 [R] KOG0586 Serine/threonine protein kinase
Length = 705
Score = 107 bits (268), Expect = 2e-23
Identities = 82/294 (27%), Positives = 140/294 (46%), Gaps = 46/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y++++ +G+G+F V+ + + + K + +N RQ+L E I+ L H NI
Sbjct: 98 YKIIKTLGKGNFAKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLNHPNI 157
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V F + TL+L MEY S+G+L + K+ R + V I Q++ A+ C
Sbjct: 158 VRLFQVIESER--TLYLVMEYASRGELFDHL--VKNGRMRERDARV--IFRQLVSAIQYC 211
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H SK V+HRDLK N+ L D N I
Sbjct: 212 H-----SKF-----------------VVHRDLKAENLLL---DQHMN------------I 234
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
K+ DFG + + + T + G+P Y +PE+ + Y+ P D WSLG +LY L S +
Sbjct: 235 KIADFGFGNTFDPNAQLET-FCGSPPYAAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSL 293
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF T EL+ +V G + +P++ S + ++++ + + ++ KR S ++++D
Sbjct: 294 PFDGGTLKELRERVLRGKYR-VPYYISMDCENLMRKFLVLNPAKRTSLSAVMSD 346
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 107 bits (266), Expect = 4e-23
Identities = 78/249 (31%), Positives = 117/249 (46%), Gaps = 44/249 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +LE IG GSFG V K R+ +V+ K + + KE + L E I+ L+H NI
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNI 63
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V D + + +Y ++G+L Q++ +PE+ V I Q++ AL+
Sbjct: 64 VHML--DSFETDKEVVVVTDY-AEGELFQILE----DDGKLPEDQVQAIAAQLVSALYYL 116
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H R ++HRD+KP NI L I
Sbjct: 117 HSHR----------------------ILHRDMKPQNILLAKGGG---------------I 139
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFG A+++ + T+ GTP YMSPE++ ++PY +D+WS+GCILYEL P
Sbjct: 140 KLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPP 199
Query: 250 FQAKTYTEL 258
F A + +L
Sbjct: 200 FYATSIFQL 208
>ECU11g1500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 300
Score = 107 bits (266), Expect = 4e-23
Identities = 88/307 (28%), Positives = 138/307 (44%), Gaps = 46/307 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+R + + RG+ G+V + EA R++V M + R+ E +LS + H +
Sbjct: 19 FRFIRRLSRGAHGTVYLLETEAPT----REKVACKSMLKRYRRYAEKEVEMLSSISHRRV 74
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V D + L + +EY + G L +MI Y V + VW ++ Q L
Sbjct: 75 VRLL--DFFPTKSGLSIILEYLNYGSLHEMIEYLMENGYRVAGDLVWSVLAQAADGLRYL 132
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI- 188
H + +IHRD+KP NI + N + V +++
Sbjct: 133 HSKQ----------------------IIHRDVKPSNILM---------NRTLVQKEELLE 161
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
KL DF LAK+L E VGTP YM+PEV+ + YS DIWSLG +YEL +L
Sbjct: 162 FKLCDFSLAKNLCGK-ESVCGIVGTPSYMAPEVVSGERYSTSVDIWSLGISIYELLTLRR 220
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFY--SKNLQDIITRCIQVDFTKRPSTWSLLNDIQCR 306
PF+ +T EL + G LPH + ++ ++ RC+ T R S ++ +D R
Sbjct: 221 PFEGRTRDELFRMIVQG---GLPHSICADREMERLVRRCL--SRTNRISARAITSDASVR 275
Query: 307 ICRKALD 313
+ + L+
Sbjct: 276 VHLRMLE 282
>At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 269
Score = 105 bits (262), Expect = 1e-22
Identities = 73/241 (30%), Positives = 112/241 (46%), Gaps = 44/241 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y ++E +G GSFG V K R+ + + K + K+ L E IL +LKH+NI
Sbjct: 6 YHVIELVGEGSFGRVYKGRRKYTGQTVAMKFIMKQGKTDKDIHSLRQEIEILRKLKHENI 65
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+E +A+ F + ++G+L +++ K +PEE V I Q++ AL
Sbjct: 66 IEMLDSFENARE---FCVVTEFAQGELFEILE----DDKCLPEEQVQAIAKQLVKALDYL 118
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H R +IHRD+KP NI + ++
Sbjct: 119 HSNR----------------------IIHRDMKPQNILIGAGS---------------VV 141
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFG A+++ + + GTP YM+PE++++QPY D+WSLG ILYEL P
Sbjct: 142 KLCDFGFARAMSTNTVVLRSIKGTPLYMAPELVKEQPYDRTVDLWSLGVILYELYVGQPP 201
Query: 250 F 250
F
Sbjct: 202 F 202
>7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 520
Score = 105 bits (262), Expect = 1e-22
Identities = 83/290 (28%), Positives = 133/290 (45%), Gaps = 47/290 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ +LE++G GS+ +V K + K V ++ R+ LI+E +L +LKH I
Sbjct: 9 FEILEKLGAGSYATVYKARHKKQRTYHAIKYVEMSTLSQTSRENLITEIRLLRELKHKYI 68
Query: 70 VEF--FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V F WD +++ +EYC+ G+LS IR +K +PE R ++ L A
Sbjct: 69 VTLQDFFWD----DKNIYIVLEYCNAGNLSAFIR----TKKALPES-TCRYFLRQLAAAV 119
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
+ D+S H DLKP N+ LT + A++V
Sbjct: 120 QYMRANDVS---------------------HFDLKPQNLLLT-------RGANNVS---- 147
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+K+ DFG A+ L+ E G+P YM+PE++R Y +D+WS+G ILYE
Sbjct: 148 -LKVADFGFAQHLKLG-EINQQLKGSPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGK 205
Query: 248 VPFQAKTYTELQGKVKAGYFEPLP--HFYSKNLQDIITRCIQVDFTKRPS 295
P+ ++T EL +++ LP S D++ R + + T R S
Sbjct: 206 APYSSRTIEELLLRIRKAEAITLPPNARISNECHDLLRRLLAHEPTARIS 255
>Hs9845489 [R] KOG0586 Serine/threonine protein kinase
Length = 691
Score = 104 bits (259), Expect = 3e-22
Identities = 98/374 (26%), Positives = 165/374 (43%), Gaps = 55/374 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRLL+ IG+G+F V+ K + K + +N+ Q+L E I+ L H NI
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 79
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F K TL+L MEY S G++ + H R + E+ QI+ A+ C
Sbjct: 80 VKLFEVIETEK--TLYLVMEYASGGEVFDYL--VAHGR--MKEKEARAKFRQIVSAVQYC 133
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRDLK N+ L D + N I
Sbjct: 134 HQ----------------------KFIVHRDLKAENLLL---DADMN------------I 156
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLHV 248
K+ DFG + + T+ G+P Y +PE+ + + Y P D+WSLG ILY L S +
Sbjct: 157 KIADFGFSNEFTFGNKL-DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 215
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRIC 308
PF + EL+ +V G + +P + S + ++++ + + ++ +KR + ++ D +
Sbjct: 216 PFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 274
Query: 309 RKALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQRVREILNGTSKPAATP 368
+ +L+ + L +Y+ + + E +D S V QR E++ AT
Sbjct: 275 HEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQD--SLVGQRYNEVM-------ATY 325
Query: 369 LITGTGPVTMPGRT 382
L+ G + G T
Sbjct: 326 LLLGYKSSELEGDT 339
>Hs9845487 [R] KOG0586 Serine/threonine protein kinase
Length = 745
Score = 104 bits (259), Expect = 3e-22
Identities = 98/374 (26%), Positives = 165/374 (43%), Gaps = 55/374 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRLL+ IG+G+F V+ K + K + +N+ Q+L E I+ L H NI
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 79
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F K TL+L MEY S G++ + H R + E+ QI+ A+ C
Sbjct: 80 VKLFEVIETEK--TLYLVMEYASGGEVFDYL--VAHGR--MKEKEARAKFRQIVSAVQYC 133
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRDLK N+ L D + N I
Sbjct: 134 HQ----------------------KFIVHRDLKAENLLL---DADMN------------I 156
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLHV 248
K+ DFG + + T+ G+P Y +PE+ + + Y P D+WSLG ILY L S +
Sbjct: 157 KIADFGFSNEFTFGNKL-DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 215
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRIC 308
PF + EL+ +V G + +P + S + ++++ + + ++ +KR + ++ D +
Sbjct: 216 PFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 274
Query: 309 RKALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQRVREILNGTSKPAATP 368
+ +L+ + L +Y+ + + E +D S V QR E++ AT
Sbjct: 275 HEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQD--SLVGQRYNEVM-------ATY 325
Query: 369 LITGTGPVTMPGRT 382
L+ G + G T
Sbjct: 326 LLLGYKSSELEGDT 339
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 104 bits (259), Expect = 3e-22
Identities = 93/374 (24%), Positives = 168/374 (44%), Gaps = 67/374 (17%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + +LE++G GS+GSV K + + +++ K+V + Q++I E +I+ Q
Sbjct: 27 EEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPV----ESDLQEIIKEISIMQQCDS 82
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
++V+++ K+ L++ MEYC G +S +IR + K + E+ + I+ L L
Sbjct: 83 PHVVKYY--GSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLTEDEIATILQSTLKGL 137
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
H+ R IHRD+K GNI L ++
Sbjct: 138 EYLHFMRK----------------------IHRDIKAGNILLN---------------TE 160
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
KL DFG+A L ++ T +GTP++M+PEV+++ Y+ ++DIWSLG E+
Sbjct: 161 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEG 220
Query: 247 HVPFQAKTYTELQGKVKAGYFEPL--------PHFYSKNLQDIITRCIQVDFTKRPSTWS 298
P Y ++ ++A + P P +S N D + +C+ +R +
Sbjct: 221 KPP-----YADIH-PMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQ 274
Query: 299 LLNDIQCRICR-----KALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQR 353
LL R + + L E + L E + +V + E+++ E + D + V
Sbjct: 275 LLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAV 334
Query: 354 VREILNGTSKPAAT 367
E+ GT + A+T
Sbjct: 335 GDEM--GTVRVAST 346
>Hs22062450 [R] KOG0586 Serine/threonine protein kinase
Length = 787
Score = 104 bits (259), Expect = 3e-22
Identities = 98/374 (26%), Positives = 165/374 (43%), Gaps = 55/374 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRLL+ IG+G+F V+ K + K + +N+ Q+L E I+ L H NI
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F K TL+L MEY S G++ + H R + E+ QI+ A+ C
Sbjct: 113 VKLFEVIETEK--TLYLVMEYASGGEVFDYL--VAHGR--MKEKEARAKFRQIVSAVQYC 166
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRDLK N+ L D + N I
Sbjct: 167 HQ----------------------KFIVHRDLKAENLLL---DADMN------------I 189
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLHV 248
K+ DFG + + T+ G+P Y +PE+ + + Y P D+WSLG ILY L S +
Sbjct: 190 KIADFGFSNEFTFGNKL-DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 248
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRIC 308
PF + EL+ +V G + +P + S + ++++ + + ++ +KR + ++ D +
Sbjct: 249 PFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVG 307
Query: 309 RKALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQRVREILNGTSKPAATP 368
+ +L+ + L +Y+ + + E +D S V QR E++ AT
Sbjct: 308 HEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQD--SLVGQRYNEVM-------ATY 358
Query: 369 LITGTGPVTMPGRT 382
L+ G + G T
Sbjct: 359 LLLGYKSSELEGDT 372
>7304358 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 493
Score = 103 bits (257), Expect = 4e-22
Identities = 80/287 (27%), Positives = 130/287 (44%), Gaps = 43/287 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F V++ V+++ K + + A++ Q+L E I +L H NI
Sbjct: 14 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 73
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V D + N +L + + G+L + I R++ E + QIL ++ C
Sbjct: 74 VRLH--DSIQEENYHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESVNHC 127
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H V+HRDLKP N+ L +
Sbjct: 128 HQNG----------------------VVHRDLKPENLLLAS------------KAKGAAV 153
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFGLA +Q + + GTP Y+SPEVL+ +PY DIW+ G ILY L + P
Sbjct: 154 KLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPP 213
Query: 250 FQAKTYTELQGKVKAGYFE-PLPHF--YSKNLQDIITRCIQVDFTKR 293
F + L ++KAG ++ P P + + +++I + + V+ KR
Sbjct: 214 FWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKR 260
>7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1612
Score = 103 bits (257), Expect = 4e-22
Identities = 85/311 (27%), Positives = 132/311 (42%), Gaps = 49/311 (15%)
Query: 15 EIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFH 74
+IG+G FG V V ++M KE+ + + + E IL +KH N+V ++
Sbjct: 1328 KIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKNLVRYY- 1386
Query: 75 WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRD 134
+ L ++ME CS+G L ++ + +PE R Q+L + + H
Sbjct: 1387 -GIEVHREELLIFMELCSEGTLESLVELTGN----LPEALTRRFTAQLLSGVSELH---- 1437
Query: 135 LSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDF 194
+ ++HRD+K NIFL VD S +KLGDF
Sbjct: 1438 ------------------KHGIVHRDIKTANIFL-------------VDGSN-SLKLGDF 1465
Query: 195 GLAKSLQASIEF---ATTYVGTPYYMSPEVL---RDQPYSPLSDIWSLGCILYELCSLHV 248
G A +QA YVGT YM+PEV + +DIWS+GC++ E+ S
Sbjct: 1466 GSAVKIQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKR 1525
Query: 249 PF-QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRI 307
P+ Q + ++ KV G P S+ D I C+Q D +R + LL C+
Sbjct: 1526 PWAQFDSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKY 1585
Query: 308 CRKALDLEKFE 318
R E+ +
Sbjct: 1586 GRDECSSEQLQ 1596
>SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 683
Score = 103 bits (256), Expect = 6e-22
Identities = 90/298 (30%), Positives = 129/298 (43%), Gaps = 46/298 (15%)
Query: 1 MNRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAI 60
++ N++ Y + IG G F +V N + + N K + +L E +
Sbjct: 32 LHNNKKNIFYTRYDCIGEGGFARCFRVKDNYGNIYAAKVIAKRSLQNDKTKLKLFGEIKV 91
Query: 61 LSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV 120
+ H NIV F D S ++L +E C L +++R +RK + E V +M+
Sbjct: 92 HQSMSHPNIVGFIDCFED--STNIYLILELCEHKSLMELLR----KRKQLTEPEVRYLMM 145
Query: 121 QILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNAS 180
QIL AL H R VIHRDLK GNI L DE N
Sbjct: 146 QILGALKYMHKKR----------------------VIHRDLKLGNIML----DESNN--- 176
Query: 181 DVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL--RDQPYSPLSDIWSLGC 238
+K+GDFGLA L E T GTP Y++PE+L + +S D+WS G
Sbjct: 177 --------VKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVDLWSAGV 228
Query: 239 ILYELCSLHVPFQAKTYTELQGKVKA-GYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
++Y L PFQ K + K+KA Y P S +D+I+ + D + RPS
Sbjct: 229 VMYALLIGKPPFQDKEVKTIYRKIKANSYSFPSNVDISAEAKDLISSLLTHDPSIRPS 286
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 103 bits (256), Expect = 6e-22
Identities = 78/303 (25%), Positives = 140/303 (45%), Gaps = 55/303 (18%)
Query: 15 EIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFH 74
+IG G +G V + ++M KE+R+ + K ++ E I +KH N+V +F
Sbjct: 1298 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYF- 1356
Query: 75 WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV-QILMALFKCHYGR 133
+ ++++MEYC +G L ++ R +E+V R+ QI +A+ H
Sbjct: 1357 -GVELHREEMYIFMEYCDEGTLEEVSRLGL-------QEHVIRLYSKQITIAINVLHE-- 1406
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
+ ++HRD+K NIFLT S +IKLGD
Sbjct: 1407 --------------------HGIVHRDIKGANIFLT---------------SSGLIKLGD 1431
Query: 194 FGLAKSLQASIEF----ATTYVGTPYYMSPEVL---RDQPYSPLSDIWSLGCILYELCSL 246
FG + L+ + + + +GT YM+PEV+ + + + +DIWSLGC++ E+ +
Sbjct: 1432 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG 1491
Query: 247 HVPFQAKTYT-ELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQC 305
P+ + ++ KV G+ P+P S +D ++ C++ D R + LL+
Sbjct: 1492 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1551
Query: 306 RIC 308
++C
Sbjct: 1552 KVC 1554
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 103 bits (256), Expect = 6e-22
Identities = 78/303 (25%), Positives = 140/303 (45%), Gaps = 55/303 (18%)
Query: 15 EIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFH 74
+IG G +G V + ++M KE+R+ + K ++ E I +KH N+V +F
Sbjct: 1347 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYF- 1405
Query: 75 WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV-QILMALFKCHYGR 133
+ ++++MEYC +G L ++ R +E+V R+ QI +A+ H
Sbjct: 1406 -GVELHREEMYIFMEYCDEGTLEEVSRLGL-------QEHVIRLYSKQITIAINVLHE-- 1455
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
+ ++HRD+K NIFLT S +IKLGD
Sbjct: 1456 --------------------HGIVHRDIKGANIFLT---------------SSGLIKLGD 1480
Query: 194 FGLAKSLQASIEF----ATTYVGTPYYMSPEVL---RDQPYSPLSDIWSLGCILYELCSL 246
FG + L+ + + + +GT YM+PEV+ + + + +DIWSLGC++ E+ +
Sbjct: 1481 FGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTG 1540
Query: 247 HVPFQAKTYT-ELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQC 305
P+ + ++ KV G+ P+P S +D ++ C++ D R + LL+
Sbjct: 1541 KRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1600
Query: 306 RIC 308
++C
Sbjct: 1601 KVC 1603
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 103 bits (256), Expect = 6e-22
Identities = 94/364 (25%), Positives = 152/364 (40%), Gaps = 48/364 (13%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L +EIG+G++G V + + + K+V ++ ++ ++ E +L L H NI
Sbjct: 20 YMLGDEIGKGAYGRVYIGLDLENGDFVAIKQVSLENIGQEDLNTIMQEIDLLKNLNHKNI 79
Query: 70 VEFFHWDHDAKSNT-LFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
V++ K+ T L + +EY G L+ +I+ K PE V + Q+L L
Sbjct: 80 VKYLG---SLKTKTHLHIILEYVENGSLANIIKPNKFGP--FPESLVTVYIAQVLEGLVY 134
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H +G VIHRD+K NI T + +
Sbjct: 135 LH--------------------EQG--VIHRDIKGANILTT---------------KEGL 157
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KL DFG+A L + + VGTPY+M+PEV+ SDIWS+GC + EL +
Sbjct: 158 VKLADFGVATKLNEADFNTHSVVGTPYWMAPEVIELSGVCAASDIWSVGCTIIELLTCVP 217
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRIC 308
P+ ++ P+P S ++ D + C + D +RP +LL+ R
Sbjct: 218 PYYDLQPMPALYRIVQDDTPPIPDSLSPDITDFLRLCFKKDSRQRPDAKTLLSHPWIRNS 277
Query: 309 RKALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQRVREILNGTSKPAATP 368
R+AL + Y E E E ++ +V E+ SK + P
Sbjct: 278 RRALRSSLRHSGTIRYMKETDSSSE----KDAEGSQEVVESVSAEKVEVTKTNSK-SKLP 332
Query: 369 LITG 372
+I G
Sbjct: 333 VIGG 336
>YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 821
Score = 102 bits (253), Expect = 1e-21
Identities = 89/308 (28%), Positives = 137/308 (43%), Gaps = 67/308 (21%)
Query: 14 EEIGRGSFGSVRKVVREADNKV----MVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
E +G+G+F +V+K + K ++ K G+M+ R E +L +L H I
Sbjct: 202 EVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTR-----ELEVLQKLNHPRI 256
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + D +S ++ ME+ S GDL + + V E+ I QIL A+
Sbjct: 257 VRLKGFYEDTES--YYMVMEFVSGGDLMDFVAAHGA----VGEDAGREISRQILTAIKYI 310
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H S G + HRDLKP NI + D V++
Sbjct: 311 H--------------------SMG--ISHRDLKPDNILIEQDDP-------------VLV 335
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQP-------------YSPLSDIWSL 236
K+ DFGLAK +Q + F T+ GT Y++PEV+R + YS L D+WS+
Sbjct: 336 KITDFGLAK-VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSM 394
Query: 237 GCILYELCSLHVPFQAKTYTELQGKVKAGYFE--PLPHF-YSKNLQDIITRCIQVDFTKR 293
GC++Y + + H+PF T +L ++ G + PL F S+ +D I +QVD R
Sbjct: 395 GCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNR 454
Query: 294 PSTWSLLN 301
+ LN
Sbjct: 455 STAAKALN 462
>HsM4505103 [R] KOG0586 Serine/threonine protein kinase
Length = 713
Score = 102 bits (253), Expect = 1e-21
Identities = 81/295 (27%), Positives = 135/295 (45%), Gaps = 48/295 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRLL+ IG+G+F V+ + + K + +N Q+L E I+ L H NI
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDL-SQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
V+ F K TL+L MEY S G + ++ + + + K ++ QI+ A+
Sbjct: 116 VKLFEVIETQK--TLYLIMEYASGGKVFDYLVAHGRMKEKEARSKF-----RQIVSAVQY 168
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH R ++HRDLK N+ L D + N
Sbjct: 169 CHQKR----------------------IVHRDLKAENLLL---DADMN------------ 191
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLH 247
IK+ DFG + + T+ G+P Y +PE+ + + Y P D+WSLG ILY L S
Sbjct: 192 IKIADFGFSNEFTVGGKL-DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGS 250
Query: 248 VPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
+PF + EL+ +V G + +P + S + ++++ R + ++ KR + ++ D
Sbjct: 251 LPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKD 304
>Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1036
Score = 102 bits (253), Expect = 1e-21
Identities = 93/314 (29%), Positives = 145/314 (45%), Gaps = 57/314 (18%)
Query: 10 YRLLEEIGRGSFGSV-RKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
Y + +G G+F V R R+ + + K + +++ K + L E IL +L+H+N
Sbjct: 9 YSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLS-KSQILLGKEIKILKELQHEN 67
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
IV + D N++FL MEYC+ GDL+ + Q K E R+ + + A +
Sbjct: 68 IVALY--DVQELPNSVFLVMEYCNGGDLADYL-----QAKGTLSEDTIRVFLHQIAAAMR 120
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
L SKG +IHRDLKP NI L+ N+ S V S +
Sbjct: 121 I-------------------LHSKG--IIHRDLKPQNILLS----YANRRKSSV--SGIR 153
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
IK+ DFG A+ L +++ A T G+P YM+PEV+ Q Y +D+WS+G ++Y+
Sbjct: 154 IKIADFGFARYLHSNM-MAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKP 212
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTW--SLLNDIQCR 306
PFQA + +L+ FY KN R + + S + +LL + R
Sbjct: 213 PFQANSPQDLR------------MFYEKN------RSLMPSIPRETSPYLANLLLGLLQR 254
Query: 307 ICRKALDLEKFERH 320
+ +D E F H
Sbjct: 255 NQKDRMDFEAFFSH 268
>Hs21361133 [R] KOG0586 Serine/threonine protein kinase
Length = 752
Score = 102 bits (253), Expect = 1e-21
Identities = 82/301 (27%), Positives = 139/301 (45%), Gaps = 37/301 (12%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRLL+ IG+G+F V+ + + K + +N Q+L E I+ L H NI
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDL-SQMIRYYKHQRKYVPEEY------VWRIMVQI 122
V+ F K TL+L MEY S G++ ++ + K + K ++ I VQ+
Sbjct: 116 VKLFEVIETEK--TLYLIMEYASGGEVFDYLVAHGKMKEKEARSKFRQGCQAGQTIKVQV 173
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
L + +S +Q + ++HRDLK N+ L D + N
Sbjct: 174 SFDLLSLMFTFIVSAVQYCHQKR----------IVHRDLKAENLLL---DADMN------ 214
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILY 241
IK+ DFG + + T+ G+P Y +PE+ + + Y P D+WSLG ILY
Sbjct: 215 ------IKIADFGFSNEFTVGGKL-DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY 267
Query: 242 ELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
L S +PF + EL+ +V G + +P + S + ++++ R + ++ KR + ++
Sbjct: 268 TLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKRFLVLNPIKRGTLEQIMK 326
Query: 302 D 302
D
Sbjct: 327 D 327
>Hs13899225 [R] KOG0586 Serine/threonine protein kinase
Length = 688
Score = 101 bits (251), Expect = 2e-21
Identities = 87/302 (28%), Positives = 132/302 (42%), Gaps = 49/302 (16%)
Query: 5 ERQP---TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAIL 61
E QP YRLL IG+G+ V+ + + K + +N Q+L E I+
Sbjct: 51 EEQPHVGNYRLLRTIGKGNSAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIM 110
Query: 62 SQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
L H NIV+ F K TL+L MEY S G++ + H R + E+ Q
Sbjct: 111 KGLNHPNIVKLFEVIETEK--TLYLVMEYASAGEVFDYL--VSHGR--MKEKEARAKFRQ 164
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
I+ A+ CH ++HRDLK N+ L D E N
Sbjct: 165 IVSAVHYCHQKN----------------------IVHRDLKAENLLL---DAEAN----- 194
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCIL 240
IK+ DFG + + T+ G+P Y +PE+ + + Y P DIWSLG IL
Sbjct: 195 -------IKIADFGFSNEFTLGSKL-DTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVIL 246
Query: 241 YELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
Y L S +PF EL+ +V G + +P + S + + I+ R + ++ KR + ++
Sbjct: 247 YTLVSGSLPFDGHNLKELRERVLRGKYR-VPFYMSTDCESILRRFLVLNPAKRCTLEQIM 305
Query: 301 ND 302
D
Sbjct: 306 KD 307
>At3g18750 [R] KOG0584 Serine/threonine protein kinase
Length = 567
Score = 100 bits (250), Expect = 3e-21
Identities = 93/308 (30%), Positives = 146/308 (47%), Gaps = 55/308 (17%)
Query: 5 ERQPTYRLL---EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHM----NAKERQQLISE 57
E PT+R + E IG+G+F +V K E D + +VR + N ER L SE
Sbjct: 20 EVDPTFRYIRYKEVIGKGAFKTVYKAFDEVDGIEVAWNQVRIDDVLQSPNCLER--LYSE 77
Query: 58 CAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWR 117
+L LKH+NI+ F++ D K+ T+ + E + G L R+Y+ + + V + V
Sbjct: 78 VRLLKSLKHNNIIRFYNSWIDDKNKTVNIITELFTSGSL----RHYRKKHRKVNMKAVKN 133
Query: 118 IMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQ 177
QILM L H E P +IHRDLK NIF+ G E
Sbjct: 134 WARQILMGLRYLH-------------GQEPP-------IIHRDLKCDNIFINGNHGE--- 170
Query: 178 NASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLG 237
+K+GD GLA ++ + A + +GTP +M+PE L D+ Y+ L+DI+S G
Sbjct: 171 -----------VKIGDLGLATVMEQA--NAKSVIGTPEFMAPE-LYDENYNELADIYSFG 216
Query: 238 CILYELCSLHVPF-QAKTYTELQGKVKAGYFEP--LPHFYSKNLQDIITRCIQVDFTKRP 294
+ E+ + P+ + K ++ KV +G +P L ++ I +C+ + ++R
Sbjct: 217 MCMLEMVTFDYPYCECKNSAQIYKKVSSG-IKPASLSRVKDPEVKQFIEKCL-LPASERL 274
Query: 295 STWSLLND 302
S LL D
Sbjct: 275 SAKELLLD 282
>YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 705
Score = 100 bits (249), Expect = 4e-21
Identities = 94/361 (26%), Positives = 159/361 (44%), Gaps = 63/361 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHW 75
+G G F ++ ++ + + + K R++L+SE I + H NIV+F
Sbjct: 88 LGEGGFARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDC 147
Query: 76 DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDL 135
D + +++ +E C G L ++++ +RK + E V QI A+ H R
Sbjct: 148 FED--DSNVYILLEICPNGSLMELLK----RRKVLTEPEVRFFTTQICGAIKYMHSRR-- 199
Query: 136 SKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFG 195
VIHRDLK GNIF +D +N +K+GDFG
Sbjct: 200 --------------------VIHRDLKLGNIF---FDSNYN------------LKIGDFG 224
Query: 196 LAKSLQASIEFATTYVGTPYYMSPEVL--RDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
LA L E T GTP Y++PEVL + +S DIWSLG +LY L PFQA+
Sbjct: 225 LAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQAR 284
Query: 254 TYTELQGKVKAGYFE-PLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN----------D 302
+ ++K F P S + +I + +D +RPS +++
Sbjct: 285 DVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFRGTFPPS 344
Query: 303 IQCRICRKALDLEKF--ERHLLNYEHELTQVGEMLEQHATE----MKRDFASAVDQRVRE 356
I + +A + E E+ L+N++ + + +LE +++ KRD+ S++ + +
Sbjct: 345 IPSTVMSEAPNFEDIPEEQSLVNFK-DCMEKSLLLESMSSDKIQRQKRDYISSIKSSIDK 403
Query: 357 I 357
+
Sbjct: 404 L 404
>At5g39440 [T] KOG0583 Serine/threonine protein kinase
Length = 494
Score = 100 bits (249), Expect = 4e-21
Identities = 81/293 (27%), Positives = 132/293 (44%), Gaps = 54/293 (18%)
Query: 8 PTYRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILS 62
P YR+ + +G GSF V+ + A K++ R +++ + K ++++ IL
Sbjct: 17 PNYRIGKTLGHGSFAKVKLALHVATGHKVAIKILNRSKIKNMGIEIKVQREI----KILR 72
Query: 63 QLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
L H +I+ ++ N +++ MEY G+L Y ++ + E+ + QI
Sbjct: 73 FLMHPHIIR--QYEVIETPNDIYVVMEYVKSGELFD----YIVEKGKLQEDEARHLFQQI 126
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
+ + CH +++HRDLKP N+ L D + N
Sbjct: 127 ISGVEYCHRN----------------------MIVHRDLKPENVLL---DSQCN------ 155
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYE 242
IK+ DFGL+ + F T G+P Y +PEV+ +PY P DIWS G ILY
Sbjct: 156 ------IKIVDFGLSNVMHDG-HFLKTSCGSPNYAAPEVISGKPYGPDVDIWSCGVILYA 208
Query: 243 LCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
L +PF + + K+K G + LP+ S +D+I R + VD T R S
Sbjct: 209 LLCGTLPFDDENIPNVFEKIKRGMY-TLPNHLSHFARDLIPRMLMVDPTMRIS 260
>CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 302
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 302
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 350
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 571
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 520
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 518
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 533
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 482
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 720
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE28051 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 559
Score = 100 bits (248), Expect = 5e-21
Identities = 81/267 (30%), Positives = 122/267 (45%), Gaps = 46/267 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + EE+G+G+F VR+ V + K + ++A++ Q+L E I +L+H NI
Sbjct: 12 YDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNI 71
Query: 70 VEFFHWDHDAKSNTLFLYMEY--CSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
V HD+ F Y+ + + G+L + I R++ E + QIL ++
Sbjct: 72 VRL----HDSIQEESFHYLVFDLVTGGELFEDIV----AREFYSEADASHCIQQILESIA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S G ++HRDLKP N+ L
Sbjct: 124 YCH--------------------SNG--IVHRDLKPENLLLAS------------KAKGA 149
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+KL DFGLA + S E + GTP Y+SPEVL+ PYS DIW+ G ILY L +
Sbjct: 150 AVKLADFGLAIEVNDS-EAWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGY 208
Query: 248 VPFQAKTYTELQGKVKAGYFE-PLPHF 273
PF + L ++KAG ++ P P +
Sbjct: 209 PPFWDEDQHRLYAQIKAGAYDYPSPEW 235
>CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1228
Score = 100 bits (248), Expect = 5e-21
Identities = 82/295 (27%), Positives = 131/295 (43%), Gaps = 55/295 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRK---EVRYGHMNAKERQQLISECAILSQLKH 66
+ ++ E+G G+FG V K V D K+ E++ G +E + + E ILS+ K
Sbjct: 34 WNIIGELGDGAFGKVEKAVSRTDPKLFAASKSIEIQEG----EELEDFLVEIEILSECKG 89
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
++ + + + N L + +E+C G + +I H K Y+ + L L
Sbjct: 90 HPVMLGLYSTYFFE-NKLTMLLEFCGGGAVDNIIVELGHVLKEDQIRYIGYYVCDALKWL 148
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
+ VIHRDLK GNI LT Q+
Sbjct: 149 HSQN-------------------------VIHRDLKAGNILLT-------QDGQ------ 170
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL-----RDQPYSPLSDIWSLGCILY 241
++L DFG++ L++ E T++GTPY+M+PEV+ +DQPY +SDIWS G L
Sbjct: 171 --VRLADFGVSAKLKSEREKRDTFIGTPYWMAPEVMACETFKDQPYDCISDIWSFGITLI 228
Query: 242 ELCSLHVPFQAKTYTELQGKVKAGYFEPL--PHFYSKNLQDIITRCIQVDFTKRP 294
E+ P + + KV+ L P ++++ DI+TRC+ D RP
Sbjct: 229 EMAQGEPPHSDVSVMRVIIKVQKSEPPTLLQPSHWTRSFSDILTRCLVKDPRNRP 283
>Hs8923922 [R] KOG0586 Serine/threonine protein kinase
Length = 795
Score = 99.8 bits (247), Expect = 6e-21
Identities = 80/294 (27%), Positives = 131/294 (44%), Gaps = 46/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRL + IG+G+F V+ + + K + +N Q+L E I+ L H NI
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F K TL+L MEY S G++ + H R + E+ QI+ A+ C
Sbjct: 120 VKLFEVIETEK--TLYLVMEYASGGEVFDYL--VAHGR--MKEKEARAKFRQIVSAVQYC 173
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRDLK N+ L G + I
Sbjct: 174 HQ----------------------KYIVHRDLKAENLLLDG---------------DMNI 196
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLHV 248
K+ DFG + + T+ G+P Y +PE+ + + Y P D+WSLG ILY L S +
Sbjct: 197 KIADFGFSNEFTVGNKL-DTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSL 255
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF + EL+ +V G + +P + S + ++++ + + ++ KR S ++ D
Sbjct: 256 PFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKD 308
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 99.8 bits (247), Expect = 6e-21
Identities = 78/302 (25%), Positives = 139/302 (45%), Gaps = 60/302 (19%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + +LE++G GS+GSV K + + +V+ K+V + Q++I E +I+ Q
Sbjct: 24 EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDS 79
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V+++ K+ L++ MEYC G +S +IR + K + E+ + I+ L L
Sbjct: 80 PYVVKYY--GSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLIEDEIATILKSTLKGL 134
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
H+ R IHRD+K GNI L ++
Sbjct: 135 EYLHFMRK----------------------IHRDIKAGNILLN---------------TE 157
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
KL DFG+A L ++ T +GTP++M+PEV+++ Y+ ++DIWSLG E+
Sbjct: 158 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEG 217
Query: 247 HVPFQAKTYTELQGKVKAGYFEPL--------PHFYSKNLQDIITRCIQVDFTKRPSTWS 298
P Y ++ ++A + P P +S + D + +C+ + +R +
Sbjct: 218 KPP-----YADIH-PMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQ 271
Query: 299 LL 300
LL
Sbjct: 272 LL 273
>Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 970
Score = 99.8 bits (247), Expect = 6e-21
Identities = 83/298 (27%), Positives = 134/298 (44%), Gaps = 44/298 (14%)
Query: 5 ERQPTYRLLEEIGRGSFGSVRKVVR-EADNKVMVRKEVRYGHMNAKERQQLISECAILSQ 63
E+ +++ +G+GSF V + + +V ++ + A Q++ +E I Q
Sbjct: 7 EKIEDFKVGNLLGKGSFAGVYRAESIHSGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQ 66
Query: 64 LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
LKH +I+E +++ D SN ++L +E C G+++ RY K++ K E M QI+
Sbjct: 67 LKHPSILELYNYFED--SNYVYLVLEMCHNGEMN---RYLKNRVKPFSENEARHFMHQII 121
Query: 124 MALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVD 183
+ H + ++HRDL N+ LT N N
Sbjct: 122 TGMLYLH----------------------SHGILHRDLTLSNLLLTR-----NMN----- 149
Query: 184 YSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
IK+ DFGLA L+ E T GTP Y+SPE+ + SD+WSLGC+ Y L
Sbjct: 150 -----IKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTL 204
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
PF T KV +E +P F S +D+I + ++ + R S S+L+
Sbjct: 205 LIGRPPFDTDTVKNTLNKVVLADYE-MPTFLSIEAKDLIHQLLRRNPADRLSLSSVLD 261
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 99.8 bits (247), Expect = 6e-21
Identities = 78/302 (25%), Positives = 139/302 (45%), Gaps = 60/302 (19%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + +LE++G GS+GSV K + + +V+ K+V + Q++I E +I+ Q
Sbjct: 24 EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV----ESDLQEIIKEISIMQQCDS 79
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V+++ K+ L++ MEYC G +S +IR + K + E+ + I+ L L
Sbjct: 80 PYVVKYY--GSYFKNTDLWIVMEYCGAGSVSDIIRL---RNKTLIEDEIATILKSTLKGL 134
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
H+ R IHRD+K GNI L ++
Sbjct: 135 EYLHFMRK----------------------IHRDIKAGNILLN---------------TE 157
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
KL DFG+A L ++ T +GTP++M+PEV+++ Y+ ++DIWSLG E+
Sbjct: 158 GHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEG 217
Query: 247 HVPFQAKTYTELQGKVKAGYFEPL--------PHFYSKNLQDIITRCIQVDFTKRPSTWS 298
P Y ++ ++A + P P +S + D + +C+ + +R +
Sbjct: 218 KPP-----YADIH-PMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQ 271
Query: 299 LL 300
LL
Sbjct: 272 LL 273
>Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 628
Score = 99.8 bits (247), Expect = 6e-21
Identities = 83/267 (31%), Positives = 126/267 (47%), Gaps = 56/267 (20%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLI---SECAILSQLKH 66
Y LE +G+G++G V+K RE+ +++ K +R + K+ Q L+ E I+S L H
Sbjct: 53 YEFLETLGKGTYGKVKK-ARESSGRLVAIKSIRKDKI--KDEQDLMHIRREIEIMSSLNH 109
Query: 67 DNIVEFFHWDHDA--KSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+I+ H+ S+ + + MEY S+GDL Y +R+ + E QI+
Sbjct: 110 PHIIAI----HEVFENSSKIVIVMEYASRGDLYD----YISERQQLSEREARHFFRQIVS 161
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
A+ CH R V+HRDLK NI L + N N
Sbjct: 162 AVHYCHQNR----------------------VVHRDLKLENILL-----DANGN------ 188
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYEL 243
IK+ DFGL+ +L +F T+ G+P Y SPE++ +PY+ P D WSLG +LY L
Sbjct: 189 ----IKIADFGLS-NLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYIL 243
Query: 244 CSLHVPFQAKTYTELQGKVKAG-YFEP 269
+PF + L ++ G Y EP
Sbjct: 244 VHGTMPFDGHDHKILVKQISNGAYREP 270
>HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 970
Score = 99.4 bits (246), Expect = 8e-21
Identities = 83/298 (27%), Positives = 133/298 (43%), Gaps = 44/298 (14%)
Query: 5 ERQPTYRLLEEIGRGSFGSVRKVVR-EADNKVMVRKEVRYGHMNAKERQQLISECAILSQ 63
E+ +++ +G+GSF V + +V ++ + A Q++ +E I Q
Sbjct: 7 EKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVKNEVKIHCQ 66
Query: 64 LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
LKH +I+E +++ D SN ++L +E C G+++ RY K++ K E M QI+
Sbjct: 67 LKHPSILELYNYFED--SNYVYLVLEMCHNGEMN---RYLKNRVKPFSENEARHFMHQII 121
Query: 124 MALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVD 183
+ H + ++HRDL N+ LT N N
Sbjct: 122 TGMLYLH----------------------SHGILHRDLTLSNLLLTR-----NMN----- 149
Query: 184 YSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
IK+ DFGLA L+ E T GTP Y+SPE+ + SD+WSLGC+ Y L
Sbjct: 150 -----IKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTL 204
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
PF T KV +E +P F S +D+I + ++ + R S S+L+
Sbjct: 205 LIGRPPFDTDTVKNTLNKVVLADYE-MPTFLSIEAKDLIHQLLRRNPADRLSLSSVLD 261
>7290249 [R] KOG0586 Serine/threonine protein kinase
Length = 1398
Score = 99.4 bits (246), Expect = 8e-21
Identities = 76/285 (26%), Positives = 125/285 (43%), Gaps = 46/285 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + IG+G+F V+ + K + ++ Q++ E I+ +LKH +I
Sbjct: 141 YDIERTIGKGNFAVVKLARHRITKNEVAIKIIDKSQLDQTNLQKVYREVEIMKRLKHPHI 200
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
++ + N +++ EY S+G++ I Y + W QI+ A+ C
Sbjct: 201 IKLYQVMET--KNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFW----QIISAVEYC 254
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H KG ++HRDLK N+ L + N N I
Sbjct: 255 H--------------------KKG--IVHRDLKAENLLL-----DLNMN----------I 277
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
K+ DFG + + E T+ G+P Y +PEV + Y+ P DIWSLG +LY L +
Sbjct: 278 KIADFGFSNHFKPG-ELLATWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGAL 336
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
PF T L+ +V +G F +P F S + +I R + ++ T+R
Sbjct: 337 PFDGSTLQSLRDRVLSGRFR-IPFFMSSECEHLIRRMLVLEPTRR 380
>Hs20545245 [D] KOG0588 Serine/threonine protein kinase
Length = 795
Score = 99.0 bits (245), Expect = 1e-20
Identities = 85/289 (29%), Positives = 131/289 (44%), Gaps = 50/289 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRL + +G+G G V+ V + + K V ++ ++ E AIL ++H ++
Sbjct: 51 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 110
Query: 70 VEFFHWDHDAKSNTLFLYM--EYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
++ HD N +LY+ E+ S G+L Y + + P+E + QI+ AL
Sbjct: 111 LKL----HDVYENKKYLYLVLEHVSGGELFD---YLVKKGRLTPKE-ARKFFRQIVSALD 162
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH Y + HRDLKP N+ L DE N
Sbjct: 163 FCH----------------------SYSICHRDLKPENLLL----DEKNN---------- 186
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPL-SDIWSLGCILYELCSL 246
I++ DFG+A SLQ T G+P+Y PEV++ + Y +D+WS G IL+ L
Sbjct: 187 -IRIADFGMA-SLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVG 244
Query: 247 HVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
+PF +L KVK G F +PHF + Q ++ I+V+ KR S
Sbjct: 245 ALPFDDDNLRQLLEKVKRGVFH-MPHFIPPDCQSLLRGMIEVEPEKRLS 292
>7299437 [R] KOG0586 Serine/threonine protein kinase
Length = 604
Score = 99.0 bits (245), Expect = 1e-20
Identities = 77/294 (26%), Positives = 135/294 (45%), Gaps = 46/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y++++ +G+G+F V+ + + + K + +N RQ+L E I+ +L H NI
Sbjct: 63 YKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNI 122
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + TL+L MEY S G+L Y + + E + Q++ A+ C
Sbjct: 123 VRLLQVIESER--TLYLVMEYVSGGELFN----YLVKNGRMRERDARVLFRQLVSAIEYC 176
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H SK ++HRDLK N+ L ++ +
Sbjct: 177 H--------------------SKS--IVHRDLKAENLLLD---------------QQMKL 199
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
K+ DFG + + + T+ G+P Y +PE+ R + YS P D WSLG +LY L S +
Sbjct: 200 KIADFGFSTTFEPKAPL-ETFCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSL 258
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF EL+ +V G + +P++ S + +I + + ++ T+R S +++ D
Sbjct: 259 PFDGTNLKELRDRVLRGKYR-VPYYVSIECESLIRKFLVLNPTQRTSLSAVMAD 311
>Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 661
Score = 98.6 bits (244), Expect = 1e-20
Identities = 77/265 (29%), Positives = 120/265 (45%), Gaps = 51/265 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLIS---ECAILSQLKH 66
Y L E +G+G++G V++ +V+ K +R + K+ Q ++ E I+S L H
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKI--KDEQDMVHIRREIEIMSSLNH 112
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+I+ + + + + + MEY SKG+L Y +R+ + E QI+ A+
Sbjct: 113 PHIISIYEVFEN--KDKIVIIMEYASKGELYD----YISERRRLSERETRHFFRQIVSAV 166
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
CH V+HRDLK NI L DD N
Sbjct: 167 HYCHKNG----------------------VVHRDLKLENILL---DDNCN---------- 191
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCS 245
IK+ DFGL+ Q +F T+ G+P Y SPE++ +PY P D W+LG +LY L
Sbjct: 192 --IKIADFGLSNLYQKD-KFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVY 248
Query: 246 LHVPFQAKTYTELQGKVKAG-YFEP 269
+PF + L ++ +G Y EP
Sbjct: 249 GTMPFDGFDHKNLIRQISSGEYREP 273
>Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 476
Score = 98.6 bits (244), Expect = 1e-20
Identities = 101/381 (26%), Positives = 165/381 (42%), Gaps = 64/381 (16%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
T+ +E +G G+F V V + K+ K ++ A L +E A+L ++KH+N
Sbjct: 22 TFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSP--AFRDSSLENEIAVLKKIKHEN 79
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
IV D + +L M+ S G+L I +R E+ ++ Q+L A+
Sbjct: 80 IVTLE--DIYESTTHYYLVMQLVSGGELFDRIL----ERGVYTEKDASLVIQQVLSAVKY 133
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNI-FLTGYDDEFNQNASDVDYSKV 187
H ++HRDLKP N+ +LT ++ SK+
Sbjct: 134 LHENG----------------------IVHRDLKPENLLYLTPEEN-----------SKI 160
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+I DFGL+K Q I +T GTP Y++PEVL +PYS D WS+G I Y L +
Sbjct: 161 MIT--DFGLSKMEQNGI--MSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGY 216
Query: 248 VPFQAKTYTELQGKVKAGYFE---PLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQ 304
PF +T ++L K+K GY+E P S++ +D I ++ D +R +
Sbjct: 217 PPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYT--------- 267
Query: 305 CRICRKALDLEKFERHLLNYEHELTQVGEMLEQHATEMK--RDF-ASAVDQRVREILNGT 361
C KAL + + + V ++++ + K + F A+AV +R++
Sbjct: 268 ---CEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAAAVVHHMRKLHMNL 324
Query: 362 SKPAATPLITGTGPVTMPGRT 382
P P + P T T
Sbjct: 325 HSPGVRPEVENRPPETQASET 345
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 98.2 bits (243), Expect = 2e-20
Identities = 79/296 (26%), Positives = 126/296 (41%), Gaps = 50/296 (16%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHW 75
+G G+ GSV K + KV K + + + + ++Q+ E K D IV+++
Sbjct: 220 LGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGM 279
Query: 76 DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDL 135
D +S+++++ MEY L + + + E + +I +L L H +
Sbjct: 280 FTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERK-- 337
Query: 136 SKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFG 195
VIHRD+KP NI L K IKL DFG
Sbjct: 338 --------------------VIHRDIKPQNILLN---------------EKGEIKLCDFG 362
Query: 196 LAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKTY 255
+ S +A A T+ GT +YM+PE ++ QPYS D+WSLG L E+ PF++
Sbjct: 363 V--SGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKI 420
Query: 256 TELQGKVK----AGYFEP-------LPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
T+ ++ F P L +SK + I C++ D +RPS +L
Sbjct: 421 TQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQML 476
>CE03080 [R] KOG0584 Serine/threonine protein kinase
Length = 1851
Score = 98.2 bits (243), Expect = 2e-20
Identities = 85/298 (28%), Positives = 137/298 (45%), Gaps = 50/298 (16%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFF 73
EE+GRGSF +V + + + E++ +N ERQ+ E +L L+H NIV F+
Sbjct: 348 EELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDLQHPNIVRFY 407
Query: 74 -HW---DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+W D K + L E + G L ++ +K RI +++++ +
Sbjct: 408 DYWESADLCGKRKYIVLVTELMTSGTLKMYLKRFK------------RINIKVVLKSWCR 455
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
+ LS L T + VIHRDLK NIF+TG +
Sbjct: 456 QILKGLSFLHT-----------RNPPVIHRDLKCDNIFITGTTGS--------------V 490
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
K+GD GLA S FA + +GTP +M+PE + ++ Y D+++ G L E+ + P
Sbjct: 491 KIGDLGLATLKNKS--FAKSVIGTPEFMAPE-MYEEMYDESVDVYAFGMCLLEMVTGEYP 547
Query: 250 FQ-----AKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
+ A Y ++ VK F +P Y + +++II RCI+V +R + LL D
Sbjct: 548 YSECMNPATIYRKVISGVKPECFSRIPAQYPE-IREIIDRCIRVRREERSTVKQLLVD 604
>At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 225
Score = 98.2 bits (243), Expect = 2e-20
Identities = 67/219 (30%), Positives = 101/219 (45%), Gaps = 41/219 (18%)
Query: 46 MNAKERQQLISECAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKH 105
+N R L +E LS + H NI+ H D + L + +EYC G LS I+ Y
Sbjct: 41 LNRNLRDCLNNELEFLSSVDHPNIIRLLHVSQD--DDFLVMVLEYCDGGTLSSYIQRYGR 98
Query: 106 QRKYVPEEYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGN 165
V E+ R M QI L H +IHRDLKP N
Sbjct: 99 ----VEEDIAKRFMKQIGAGLEIIHDNH----------------------IIHRDLKPEN 132
Query: 166 IFLTGYDDEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQ 225
I + G D+ +++K+ DF LA+ L ++ T G+P+YM+PEVL+ Q
Sbjct: 133 ILIDGSGDD------------LVLKIADFSLARKLHPG-KYLETVCGSPFYMAPEVLQFQ 179
Query: 226 PYSPLSDIWSLGCILYELCSLHVPFQAKTYTELQGKVKA 264
Y+ +D+WS+G IL+EL + PF+ ++ +K+
Sbjct: 180 RYNEKADMWSVGAILFELLHGYPPFRGNNNVQVLRNIKS 218
>Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 97.8 bits (242), Expect = 2e-20
Identities = 79/289 (27%), Positives = 134/289 (46%), Gaps = 47/289 (16%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK--ERQQLISECAILSQLKHDNIVEFF 73
+G+G F ++ +AD K + ++ + K +R+++ E +I L H ++V F
Sbjct: 59 LGKGGFAKCFEI-SDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 117
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
+ D ++ +F+ +E C + L ++ + +RK + E + QI++ H R
Sbjct: 118 GFFED--NDFVFVVLELCRRRSLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRNR 171
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
VIHRDLK GN+FL D++ +K+GD
Sbjct: 172 ----------------------VIHRDLKLGNLFLN----------EDLE-----VKIGD 194
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FGLA ++ E T GTP Y++PEVL + +S D+WS+GCI+Y L PF+
Sbjct: 195 FGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETS 254
Query: 254 TYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
E ++K + +P + +I + +Q D T RP+ LLND
Sbjct: 255 CLKETYLRIKKNEYS-IPKHINPVAASLIQKMLQTDPTARPTINELLND 302
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 97.8 bits (242), Expect = 2e-20
Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 46/244 (18%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + ++ ++G GS+GSV K + V+ K+V + Q++I E +I+ Q K
Sbjct: 60 EEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVD----TDLQEIIKEISIMQQCKS 115
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V+++ K + L++ MEYC G +S ++R +RK + E+ + ++ L L
Sbjct: 116 KYVVKYY--GSYFKHSDLWIVMEYCGAGSISDIMRA---RRKPLSEQEISAVLRDTLKGL 170
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
Y DL K IHRD+K GNI L +
Sbjct: 171 ---QYLHDLKK-------------------IHRDIKAGNILLN---------------TD 193
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
I KL DFG+A L ++ T +GTP++M+PEV+ + Y +DIWSLG E+
Sbjct: 194 GIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEG 253
Query: 247 HVPF 250
P+
Sbjct: 254 RPPY 257
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 97.8 bits (242), Expect = 2e-20
Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 46/244 (18%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + ++ ++G GS+GSV K + V+ K+V + Q++I E +I+ Q K
Sbjct: 32 EEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVD----TDLQEIIKEISIMQQCKS 87
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V+++ K + L++ MEYC G +S ++R +RK + E+ + ++ L L
Sbjct: 88 KYVVKYY--GSYFKHSDLWIVMEYCGAGSISDIMRA---RRKPLSEQEISAVLRDTLKGL 142
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
Y DL K IHRD+K GNI L +
Sbjct: 143 ---QYLHDLKK-------------------IHRDIKAGNILLN---------------TD 165
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
I KL DFG+A L ++ T +GTP++M+PEV+ + Y +DIWSLG E+
Sbjct: 166 GIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEG 225
Query: 247 HVPF 250
P+
Sbjct: 226 RPPY 229
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 97.8 bits (242), Expect = 2e-20
Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 46/244 (18%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + ++ ++G GS+GSV K + V+ K+V + Q++I E +I+ Q K
Sbjct: 32 EEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVD----TDLQEIIKEISIMQQCKS 87
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V+++ K + L++ MEYC G +S ++R +RK + E+ + ++ L L
Sbjct: 88 KYVVKYY--GSYFKHSDLWIVMEYCGAGSISDIMRA---RRKPLSEQEISAVLRDTLKGL 142
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
Y DL K IHRD+K GNI L +
Sbjct: 143 ---QYLHDLKK-------------------IHRDIKAGNILLN---------------TD 165
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
I KL DFG+A L ++ T +GTP++M+PEV+ + Y +DIWSLG E+
Sbjct: 166 GIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEG 225
Query: 247 HVPF 250
P+
Sbjct: 226 RPPY 229
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 97.8 bits (242), Expect = 2e-20
Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 46/244 (18%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + ++ ++G GS+GSV K + V+ K+V + Q++I E +I+ Q K
Sbjct: 60 EEVFDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVD----TDLQEIIKEISIMQQCKS 115
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V+++ K + L++ MEYC G +S ++R +RK + E+ + ++ L L
Sbjct: 116 KYVVKYY--GSYFKHSDLWIVMEYCGAGSISDIMRA---RRKPLSEQEISAVLRDTLKGL 170
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
Y DL K IHRD+K GNI L +
Sbjct: 171 ---QYLHDLKK-------------------IHRDIKAGNILLN---------------TD 193
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
I KL DFG+A L ++ T +GTP++M+PEV+ + Y +DIWSLG E+
Sbjct: 194 GIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEG 253
Query: 247 HVPF 250
P+
Sbjct: 254 RPPY 257
>At4g08500 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 97.8 bits (242), Expect = 2e-20
Identities = 83/292 (28%), Positives = 134/292 (45%), Gaps = 53/292 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER---QQLISECAILSQLKHDNIVEF 72
+GRGSFGSV + + D KEV ++ + QQL E +LSQL+H NIV +
Sbjct: 339 LGRGSFGSVYEGI-SGDGDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQLQHQNIVRY 397
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
D + L++++E ++G L ++ +QR + + V QIL L H
Sbjct: 398 RGTAKDGSN--LYIFLELVTQGSLLKL-----YQRYQLRDSVVSLYTRQILDGLKYLH-- 448
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
KG+ IHRD+K NI + + +KL
Sbjct: 449 ------------------DKGF--IHRDIKCANILVD---------------ANGAVKLA 473
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQP---YSPLSDIWSLGCILYELCSLHVP 249
DFGLAK + + GTP++M+PEV+ + Y +DIWSLGC + E+C+ +P
Sbjct: 474 DFGLAKV--SKFNDIKSCKGTPFWMAPEVINRKDSDGYGSPADIWSLGCTVLEMCTGQIP 531
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
+ + ++ G +P S + + I +C++V+ +RP+ LLN
Sbjct: 532 YSDLEPVQALFRIGRGTLPEVPDTLSLDARLFILKCLKVNPEERPTAAELLN 583
>CE28218 [D] KOG0588 Serine/threonine protein kinase
Length = 914
Score = 97.4 bits (241), Expect = 3e-20
Identities = 82/287 (28%), Positives = 128/287 (44%), Gaps = 46/287 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+L + +G+G G V+ + + K V ++ Q++ E AI+ ++H ++
Sbjct: 47 YKLEKTLGKGQTGLVKTGTHCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIEHPHV 106
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ + D L+L +E+ S G+L Y ++ + + + QI+ AL C
Sbjct: 107 LHLY--DVYENKKYLYLLLEHVSGGELFD----YLVRKGRLMSKEARKFFRQIISALDFC 160
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + + HRDLKP N+ L DE N I
Sbjct: 161 H----------------------AHNICHRDLKPENLLL----DERNN-----------I 183
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPL-SDIWSLGCILYELCSLHV 248
K+ DFG+A SLQ T G+P+Y PEV+R + Y +D+WS G ILY L +
Sbjct: 184 KVADFGMA-SLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGAL 242
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
PF L KVK G F +PHF ++Q ++ I+VD KR S
Sbjct: 243 PFDDDNLRNLLEKVKRGVFH-IPHFVPADVQSLLRAMIEVDPGKRYS 288
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 97.4 bits (241), Expect = 3e-20
Identities = 79/293 (26%), Positives = 132/293 (44%), Gaps = 53/293 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER---QQLISECAILSQLKHDNIVEF 72
+G GSFG V ++ KEV + K R QQL E ++LS+L+H NIV++
Sbjct: 406 LGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLRHQNIVQY 465
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
+ + + L++Y+EY S G + ++++ Y + Y QIL L H
Sbjct: 466 Y--GSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIRNYTQ----QILSGLAYLHAK 519
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
+HRD+K NI + + +K+
Sbjct: 520 N----------------------TVHRDIKGANILVDPHGR---------------VKVA 542
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLS-DIWSLGCILYELCSLHVPFQ 251
DFG+AK + A ++ G+PY+M+PEV+++ S L+ DIWSLGC + E+ + P+
Sbjct: 543 DFGMAKHITAQ-SGPLSFKGSPYWMAPEVIKNSNGSNLAVDIWSLGCTVLEMATTKPPW- 600
Query: 252 AKTYTELQGKVKAGYFEPLPHF---YSKNLQDIITRCIQVDFTKRPSTWSLLN 301
Y + K G + LP S+ +D + +C+Q + RP+ LL+
Sbjct: 601 -SQYEGVPAMFKIGNSKELPDIPDHLSEEGKDFVRKCLQRNPANRPTAAQLLD 652
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 97.1 bits (240), Expect = 4e-20
Identities = 65/243 (26%), Positives = 112/243 (45%), Gaps = 44/243 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHM-NAKERQQLISECAILSQLKHDNIVEFFH 74
+G+G F ++ +NKV K + + + +R+++ E + L H ++V+F+H
Sbjct: 88 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYH 147
Query: 75 WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRD 134
+ D ++ +++ +EYCS+ ++ +++ RK + E V + QI+ L H
Sbjct: 148 YFEDKEN--IYILLEYCSRRSMAHILK----ARKVLTEPEVRYYLRQIVSGLKYLHEQE- 200
Query: 135 LSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDF 194
++HRDLK GN F+ + +K+GDF
Sbjct: 201 ---------------------ILHRDLKLGNFFIN---------------EAMELKVGDF 224
Query: 195 GLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKT 254
GLA L+ T GTP Y+SPEVL Q + SDIW+LGC++Y + PF+
Sbjct: 225 GLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTN 284
Query: 255 YTE 257
E
Sbjct: 285 LKE 287
>HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 96.7 bits (239), Expect = 5e-20
Identities = 79/289 (27%), Positives = 133/289 (45%), Gaps = 47/289 (16%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK--ERQQLISECAILSQLKHDNIVEFF 73
+G+G F ++ +AD K + ++ + K +R+++ E +I L H ++V F
Sbjct: 59 LGKGGFAKCFEI-SDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFH 117
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
+ D ++ +F+ +E C + L + + +RK + E + QI++ H R
Sbjct: 118 GFFED--NDFVFVVLELCRRRSLLEPHK----RRKALTEPEARYYLRQIVLGCQYLHRNR 171
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
VIHRDLK GN+FL D++ +K+GD
Sbjct: 172 ----------------------VIHRDLKLGNLFLN----------EDLE-----VKIGD 194
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FGLA ++ E T GTP Y++PEVL + +S D+WS+GCI+Y L PF+
Sbjct: 195 FGLATKVEYDGERKKTLCGTPNYIAPEVLSKKEHSFEVDVWSIGCIMYTLLVGKPPFETS 254
Query: 254 TYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
E ++K + +P + +I + +Q D T RP+ LLND
Sbjct: 255 CLKETYLRIKKNEYS-IPKHINPVAASLIQKMLQTDPTARPTINELLND 302
>Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 607
Score = 96.7 bits (239), Expect = 5e-20
Identities = 71/267 (26%), Positives = 126/267 (46%), Gaps = 48/267 (17%)
Query: 34 KVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSK 93
KV+ + V H +R+++++E + L+H +IV F H DA + +++++E CS+
Sbjct: 52 KVIPQSRVAKPH----QREKILNEIELHRDLQHRHIVRFSHHFEDA--DNIYIFLELCSR 105
Query: 94 GDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKG 153
L+ ++W+ +L + + + LS L+ ++ +G
Sbjct: 106 KSLA----------------HIWKARHTLLEPEVRYYLRQILSGLKYLHQ--------RG 141
Query: 154 YVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGT 213
++HRDLK GN F+T + +K+GDFGLA L+ + T GT
Sbjct: 142 --ILHRDLKLGNFFIT---------------ENMELKVGDFGLAARLEPPEQRKKTICGT 184
Query: 214 PYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHF 273
P Y++PEVL Q + P +D+WSLGC++Y L PF+ E +K ++ LP
Sbjct: 185 PNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHY-TLPAS 243
Query: 274 YSKNLQDIITRCIQVDFTKRPSTWSLL 300
S + ++ ++ RPS +L
Sbjct: 244 LSLPARQLLAAILRASPRDRPSIDQIL 270
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 96.7 bits (239), Expect = 5e-20
Identities = 80/294 (27%), Positives = 135/294 (45%), Gaps = 46/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+LL+ IG+G+F V+ + K + +N Q+L E I+ QL H NI
Sbjct: 122 YKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNI 181
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ + + TL+L +EY S G++ + H R E
Sbjct: 182 VKLYQVMETEQ--TLYLVLEYASGGEVFDYL--VAHGRMKEKEAR--------------- 222
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
+K + I A++ L SK +IHRDLK N+ L D + N I
Sbjct: 223 ------AKFRQIVSAVQY-LHSKN--IIHRDLKAENLLL---DQDMN------------I 258
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
K+ DFG + + + T+ G+P Y +PE+ + Y P D+WSLG ILY L S +
Sbjct: 259 KIADFGFSNTFSLGNKL-DTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSL 317
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF + EL+ +V G + +P + S + ++++ + + ++ +R S +++ D
Sbjct: 318 PFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLVINPQRRSSLDNIMKD 370
>CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 648
Score = 96.7 bits (239), Expect = 5e-20
Identities = 77/288 (26%), Positives = 137/288 (46%), Gaps = 46/288 (15%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK-ERQQLISECAILSQLKHDNIVEFFH 74
+G+G F ++ A +V+ K V + + +R ++ E I +L H NIV+ F+
Sbjct: 44 LGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFN 103
Query: 75 WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRD 134
+ D + +++ +E C++ L ++ + +RK V E QI+ + H D
Sbjct: 104 FFED--NLNVYITLELCARRSLMELHK----RRKAVTEPEARYFTHQIVDGVLYLH---D 154
Query: 135 LSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDF 194
L+ +IHRD+K GN+FL DD +++K+GDF
Sbjct: 155 LN-------------------IIHRDMKLGNLFLN--DD-------------LVVKIGDF 180
Query: 195 GLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKT 254
GLA ++ E T GTP Y++PEVL +S DIW++GCILY L PF++K+
Sbjct: 181 GLATTVNGD-ERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFESKS 239
Query: 255 YTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
E +++ + +P ++ +I + + + T+RP+ + D
Sbjct: 240 LEETYSRIRHNNY-TIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRD 286
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 96.7 bits (239), Expect = 5e-20
Identities = 80/294 (27%), Positives = 135/294 (45%), Gaps = 46/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+LL+ IG+G+F V+ + K + +N Q+L E I+ QL H NI
Sbjct: 170 YKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDHPNI 229
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ + + TL+L +EY S G++ + H R E
Sbjct: 230 VKLYQVMETEQ--TLYLVLEYASGGEVFDYL--VAHGRMKEKEAR--------------- 270
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
+K + I A++ L SK +IHRDLK N+ L D + N I
Sbjct: 271 ------AKFRQIVSAVQY-LHSKN--IIHRDLKAENLLL---DQDMN------------I 306
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
K+ DFG + + + T+ G+P Y +PE+ + Y P D+WSLG ILY L S +
Sbjct: 307 KIADFGFSNTFSLGNKL-DTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSL 365
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF + EL+ +V G + +P + S + ++++ + + ++ +R S +++ D
Sbjct: 366 PFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLVINPQRRSSLDNIMKD 418
>At4g08480 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 773
Score = 96.7 bits (239), Expect = 5e-20
Identities = 79/290 (27%), Positives = 135/290 (46%), Gaps = 53/290 (18%)
Query: 18 RGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER---QQLISECAILSQLKHDNIVEFFH 74
+GSFGSV + + E D KEV ++ + QQL E A+LSQL+H NI+ +
Sbjct: 509 QGSFGSVYEAISE-DGDFFAVKEVSLLDQGSQAQECIQQLEGEIALLSQLEHQNILRYRG 567
Query: 75 WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRD 134
D D + L++++E ++G L ++ R Y+ + + + QIL L H+
Sbjct: 568 TDKDGSN--LYIFLELVTQGSLLELYRRYQ-----IRDSLISLYTKQILDGLKYLHH--- 617
Query: 135 LSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDF 194
KG+ IHRD+K I + + +KL DF
Sbjct: 618 -----------------KGF--IHRDIKCATILVD---------------ANGTVKLADF 643
Query: 195 GLAKSLQASIEFATTYVGTPYYMSPEVLR---DQPYSPLSDIWSLGCILYELCSLHVPFQ 251
GLAK + + + T ++M+PEV+ + Y +DIWSLGC + E+C+ +P+
Sbjct: 644 GLAKV--SKLNDIKSRKETLFWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYS 701
Query: 252 AKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
E +++ G +P S + + I +C++++ +RP+ LLN
Sbjct: 702 DLEPVEALFRIRRGTLPEVPDTLSLDARHFILKCLKLNPEERPTATELLN 751
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 96.7 bits (239), Expect = 5e-20
Identities = 85/328 (25%), Positives = 142/328 (42%), Gaps = 54/328 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ ++ E+G G+FG V K + + K + + + + E ILS++KH NI
Sbjct: 37 WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLE--DEENLSDHMVEIDILSEIKHPNI 94
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
VE + + + + L++ +EYC G L ++ + YV + M + L L +
Sbjct: 95 VELY--EAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLHRN 152
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
VIHRDLK GN+ LT +
Sbjct: 153 K-------------------------VIHRDLKAGNVLLTMEGG---------------V 172
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL-----RDQPYSPLSDIWSLGCILYELC 244
KL DFG++ + +++ T++GTPY+M+PE++ RD PY DIWSLG L EL
Sbjct: 173 KLADFGVSAKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELA 232
Query: 245 SLHVPFQAKTYTELQGKVKAGYFEPL--PHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
+ P + + K++ L P +SK D + + + D RP+T L+
Sbjct: 233 QMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLM-- 290
Query: 303 IQCRICRKALDLEKFERHLLNYEHELTQ 330
Q + LD + + LL Y+ E+ +
Sbjct: 291 -QHAFINRNLDAKPIKDLLLEYKAEVVE 317
>SPAC23A1.06c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 504
Score = 95.9 bits (237), Expect = 9e-20
Identities = 80/302 (26%), Positives = 133/302 (43%), Gaps = 45/302 (14%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y+L+E +G G+F V K + + K +R MN K+RQ + E I+ ++KH N+
Sbjct: 65 YQLIENLGDGAFSQVYKAYSIDRKEHVAVKVIRKYEMNKKQRQGVFKEVNIMRRVKHKNV 124
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V F D + L ME G+L I + Y E I++Q+ A+
Sbjct: 125 VNLF--DFVETEDFYHLVMELAEGGELFHQIVNFT----YFSENLARHIIIQVAEAVKHL 178
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQN-------ASDV 182
H D+ ++HRD+KP N+ + +QN + +
Sbjct: 179 H---DVCG------------------IVHRDIKPENLLFQPIEYLPSQNYTPPSLEPNKL 217
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFA--------TTYVGTPYYMSPEVLRDQPYSPLSDIW 234
D + +G G+ + L A F+ T GT Y +PE++ D+ YS D+W
Sbjct: 218 DEGMFLEGIGAGGIGRILIADFGFSKVVWNSKTATPCGTVGYAAPEIVNDELYSKNVDMW 277
Query: 235 SLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFY---SKNLQDIITRCIQVDFT 291
++GC+L+ + PF + +L KV G FE L ++ S + +D+IT + VD
Sbjct: 278 AMGCVLHTMLCGFPPFFDENIKDLASKVVNGEFEFLSPWWDDISDSAKDLITHLLTVDPR 337
Query: 292 KR 293
+R
Sbjct: 338 ER 339
>Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 358
Score = 95.1 bits (235), Expect = 2e-19
Identities = 71/237 (29%), Positives = 105/237 (43%), Gaps = 44/237 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +IG GS+G V K +++ K+ + ++ + E +L QLKH N+
Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNL 64
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + + L L EYC L ++ RY ++ VPE V I Q L A+ C
Sbjct: 65 VNLL--EVFRRKRRLHLVFEYCDHTVLHELDRY----QRGVPEHLVKSITWQTLQAVNFC 118
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + IHRD+KP NI +T + +I
Sbjct: 119 HK----------------------HNCIHRDVKPENILITKHS---------------VI 141
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL-RDQPYSPLSDIWSLGCILYELCS 245
KL DFG A+ L ++ T YV T +Y SPE+L D Y P D+W++GC+ EL S
Sbjct: 142 KLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLS 198
>At3g01090 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 95.1 bits (235), Expect = 2e-19
Identities = 82/293 (27%), Positives = 129/293 (43%), Gaps = 57/293 (19%)
Query: 8 PTYRLLEEIGRGSFGSVRKVVREADN------KVMVRKEVRYGHMNAKERQQLISECAIL 61
P Y+L +G GSFG V K+ A K++ R++++ M K R+++ IL
Sbjct: 17 PNYKLGRTLGIGSFGRV-KIAEHALTGHKVAIKILNRRKIKNMEMEEKVRREI----KIL 71
Query: 62 SQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
H +I+ + + ++L MEY + G+L Y ++ + E+ Q
Sbjct: 72 RLFMHPHIIRLY--EVIETPTDIYLVMEYVNSGELFD----YIVEKGRLQEDEARNFFQQ 125
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
I+ + CH +V+HRDLKP N+ L
Sbjct: 126 IISGVEYCHRN----------------------MVVHRDLKPENLLLD------------ 151
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCIL 240
SK +K+ DFGL+ ++ F T G+P Y +PEV+ + Y+ P D+WS G IL
Sbjct: 152 ---SKCNVKIADFGLSNIMRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVIL 207
Query: 241 YELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
Y L +PF + L K+K G + LP S +D+I R + VD KR
Sbjct: 208 YALLCGTLPFDDENIPNLFKKIKGGIY-TLPSHLSPGARDLIPRMLVVDPMKR 259
>YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 380
Score = 94.7 bits (234), Expect = 2e-19
Identities = 82/295 (27%), Positives = 140/295 (46%), Gaps = 68/295 (23%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN------KVMVRKEVRYGHMNAKERQQLISECAILSQ 63
++++ +G GSFG V +VR N KV+ +++V + K+ + E +L
Sbjct: 70 FQIMRTLGTGSFGRVH-LVRSVHNGRYYAIKVLKKQQV----VKMKQVEHTNDERRMLKL 124
Query: 64 LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
++H ++ + DA++ +F+ M+Y G+L ++R K QR P +++
Sbjct: 125 VEHPFLIRMWGTFQDARN--IFMVMDYIEGGELFSLLR--KSQR--FPNPVAKFYAAEVI 178
Query: 124 MALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVD 183
+AL H + +I+RDLKP NI L ++N
Sbjct: 179 LALEYLH----------------------AHNIIYRDLKPENILL-------DRNGH--- 206
Query: 184 YSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
IK+ DFG AK +Q T GTP Y++PEV+ +PY+ D WSLG ++YE+
Sbjct: 207 -----IKITDFGFAKEVQT---VTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEM 258
Query: 244 CSLHVPF----QAKTYTE-LQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
+ + PF KTY + LQGKV P ++ ++ D++++ I D T+R
Sbjct: 259 LAGYTPFYDTTPMKTYEKILQGKV------VYPPYFHPDVVDLLSKLITADLTRR 307
>7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 835
Score = 94.7 bits (234), Expect = 2e-19
Identities = 82/279 (29%), Positives = 131/279 (46%), Gaps = 42/279 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVV-READNKVMVRKEVRYGHMNAKERQQLISECAIL---SQLK 65
Y + +G G+F V K R+ V ++ + G + K + L E IL ++L
Sbjct: 9 YSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCITKKGQL--KTQNLLGKEIKILKELTELH 66
Query: 66 HDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMA 125
H+N+V D + + L MEYC+ GDL+ Y + + E+ V +VQ+ A
Sbjct: 67 HENVVALL--DCKESQDCVSLVMEYCNGGDLAD----YLSVKGTLSEDTVRLFLVQLAGA 120
Query: 126 LFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYS 185
+ + L +KG ++HRDLKP NI L+ N + S
Sbjct: 121 M--------------------KALYTKG--IVHRDLKPQNILLS-----HNYGKTLPAPS 153
Query: 186 KVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCS 245
K+ +K+ DFG A+ L A T G+P YM+PEV+ Y +D+WSLG I+Y+ +
Sbjct: 154 KITLKIADFGFARFLNEGA-MAATLCGSPMYMAPEVIMSLQYDSKADLWSLGTIVYQCLT 212
Query: 246 LHVPFQAKTYTELQG--KVKAGYFEPLPHFYSKNLQDII 282
PF A+T EL+ + A +P S +L+D++
Sbjct: 213 GKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLL 251
>7290150 [T] KOG0583 Serine/threonine protein kinase
Length = 582
Score = 94.7 bits (234), Expect = 2e-19
Identities = 80/290 (27%), Positives = 141/290 (48%), Gaps = 55/290 (18%)
Query: 10 YRLLEEIGRGSFGSVR----KVVR-EADNKVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y L +G G+FG V+ ++ R + K++ R++++ + K R+++ + L
Sbjct: 28 YLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQN----LKLF 83
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+H +I++ + + + +F+ MEY S G+L I KH + + E R QI+
Sbjct: 84 RHPHIIKLYQVI--STPSDIFMIMEYVSGGELFDYI--VKHGK--LQEHQARRFFQQIIS 137
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
+ CH ++++HRDLKP N+ L + N +
Sbjct: 138 GVDYCHR----------------------HMIVHRDLKPENLLL-----DHNMH------ 164
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYEL 243
+K+ DFGL+ ++ EF T G+P Y +PEV+ + Y+ P DIWS G ILY L
Sbjct: 165 ----VKIADFGLS-NMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYAL 219
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
+PF + L K+K+G F P+P + +K + +++ + +QVD KR
Sbjct: 220 LCGTLPFDDEHVPTLFRKIKSGIF-PIPEYLNKQVVNLVCQMLQVDPLKR 268
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 94.4 bits (233), Expect = 3e-19
Identities = 80/292 (27%), Positives = 127/292 (43%), Gaps = 49/292 (16%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRY---GHMNAKERQQLISECAILSQLKHDNIVEF 72
+G+G+FG V + + K+V++ +KE L E +L L+H+ IV++
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQY 427
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
+ D TL ++MEY G + ++ Y + V +Y QIL + H
Sbjct: 428 YGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTR----QILEGMSYLHSN 483
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
+++HRD+K NI +A +V KLG
Sbjct: 484 ----------------------MIVHRDIKGANIL--------RDSAGNV-------KLG 506
Query: 193 DFGLAKSLQASIEFAT---TYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
DFG +K LQ T + GTPY+MSPEV+ + Y +D+WSLGC + E+ + P
Sbjct: 507 DFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPP 566
Query: 250 FQAKTYTELQGKVKAGYFEP-LPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ K+ P LP S++ +D + R I V+ +RPS LL
Sbjct: 567 WAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELL 617
>CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 632
Score = 94.4 bits (233), Expect = 3e-19
Identities = 79/299 (26%), Positives = 137/299 (45%), Gaps = 46/299 (15%)
Query: 5 ERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK-ERQQLISECAILSQ 63
ER+ Y + +G+G F ++ ++ ++ K V + + +R ++ E I
Sbjct: 31 ERKTRYEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRN 90
Query: 64 LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
L+H N+V+ +H+ D KSN +++ +E C + L ++ + +RK V E QI+
Sbjct: 91 LQHRNVVKLYHFFED-KSN-VYITLELCPRRSLMELHK----RRKAVTEPEARYFTYQIV 144
Query: 124 MALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVD 183
+ H ++HRDLK GN+FL +DE
Sbjct: 145 EGVLYLH----------------------NLKIVHRDLKLGNLFL---NDELQ------- 172
Query: 184 YSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
+K+GDFGLA + E T GTP Y++PEVL +S D+W++GCILY L
Sbjct: 173 -----VKIGDFGLATTCDND-ERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYIL 226
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
H PF++K+ E ++K + +P S +I + ++RP+ ++ D
Sbjct: 227 LFGHPPFESKSLEETYSRIKNNNY-VIPTSASAAASQLIRVLLDPVPSRRPNARAVCRD 284
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 94.4 bits (233), Expect = 3e-19
Identities = 82/337 (24%), Positives = 148/337 (43%), Gaps = 56/337 (16%)
Query: 11 RLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLK-HDNI 69
R+ IG G+ V++ + +++++ K++ ++RQQL++E L + H+ +
Sbjct: 84 RVFGAIGSGASSVVQRAIHIPNHRILALKKINI--FEREKRQQLLTEIRTLCEAPCHEGL 141
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+F + S + + +EY + G L+ +++ K +PE + + ++L L
Sbjct: 142 VDFHGAFYSPDSGQISIALEYMNGGSLADILKVTKK----IPEPVLSSLFHKLLQGLSYL 197
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H R L +HRD+KP N+ + +
Sbjct: 198 HGVRHL---------------------VHRDIKPANLLINLKGEP--------------- 221
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
K+ DFG++ L+ S+ T+VGT YMSPE +R+ YS +DIWSLG L+E + P
Sbjct: 222 KITDFGISAGLENSMAMCATFVGTVTYMSPERIRNDSYSYPADIWSLGLALFECGTGEFP 281
Query: 250 FQAKTYTELQGKVKAG---YFEPLP----HFYSKNLQDIITRCIQVDFTKRPSTWSLL-N 301
+ A +G V +P P +S I C+Q D RP+ LL +
Sbjct: 282 YIAN-----EGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQKDPDARPTADQLLSH 336
Query: 302 DIQCRICRKALDLEKFERHLLNYEHELTQVGEMLEQH 338
+ ++ +DL F + + + L + +ML H
Sbjct: 337 PFITKHEKERVDLATFVQSIFDPTQRLKDLADMLTIH 373
>At3g29160 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 94.4 bits (233), Expect = 3e-19
Identities = 79/292 (27%), Positives = 129/292 (44%), Gaps = 55/292 (18%)
Query: 8 PTYRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILS 62
P Y+L + +G GSFG V+ K++ R++++ M K R+++ IL
Sbjct: 18 PNYKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREI----KILR 73
Query: 63 QLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
H +I+ ++ ++ +++ MEY G+L Y ++ + E+ QI
Sbjct: 74 LFMHPHIIR--QYEVIETTSDIYVVMEYVKSGELFD----YIVEKGRLQEDEARNFFQQI 127
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
+ + CH +V+HRDLKP N+ L
Sbjct: 128 ISGVEYCHRN----------------------MVVHRDLKPENLLLD------------- 152
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILY 241
S+ IK+ DFGL+ ++ F T G+P Y +PEV+ + Y+ P D+WS G ILY
Sbjct: 153 --SRCNIKIADFGLSNVMRDG-HFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILY 209
Query: 242 ELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
L +PF + L K+K G + LP S +D+I R + VD KR
Sbjct: 210 ALLCGTLPFDDENIPNLFKKIKGGIY-TLPSHLSSEARDLIPRMLIVDPVKR 260
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 94.4 bits (233), Expect = 3e-19
Identities = 80/311 (25%), Positives = 130/311 (41%), Gaps = 56/311 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +E+IG+G+ G+V + + + K++ KE +I+E ++ + KH N+
Sbjct: 430 YTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKEL--IINEILVMRENKHPNV 487
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + D S L++ MEY G L+ ++ + E + + ++L AL
Sbjct: 488 VNYL--DSYLVSEELWVVMEYLPGGSLTDVVT-----ETCMDEGQIAAVCREVLQALEFL 540
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + VIHRD+K NI L G D +
Sbjct: 541 HANQ----------------------VIHRDIKSDNILL-GLDGS--------------V 563
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFG + TT VGTPY+M+PEV+ + Y P D+WSLG + E+ P
Sbjct: 564 KLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPP 623
Query: 250 F------QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDI 303
+ +A GK + + L S QD + +C++V+ +R S LL
Sbjct: 624 YLNENPLKALYLIATNGKPEIKEKDKL----SSAFQDFLDQCLEVEVDRRASALDLLKHP 679
Query: 304 QCRICRKALDL 314
++ R L
Sbjct: 680 FLKLARPLASL 690
>7294217 [D] KOG0588 Serine/threonine protein kinase
Length = 851
Score = 94.4 bits (233), Expect = 3e-19
Identities = 82/285 (28%), Positives = 127/285 (43%), Gaps = 46/285 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRL + +G+G G V+ V K + K + ++ ++ E AI+ + H ++
Sbjct: 18 YRLEKTLGKGQTGLVKLGVHCVIGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHV 77
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ D L+L +E+ S G+L Y + + P+E + QI+ AL C
Sbjct: 78 LGLS--DVYENKKYLYLILEHVSGGELFD---YLVKKGRLTPKE-ARKFFRQIISALDFC 131
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + + HRDLKP N+ L DE N I
Sbjct: 132 H----------------------SHSICHRDLKPENLLL----DEKNN-----------I 154
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPL-SDIWSLGCILYELCSLHV 248
K+ DFG+A SLQ + T G+P+Y PEV+R + Y +D+WS G ILY L +
Sbjct: 155 KIADFGMA-SLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGAL 213
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
PF +L KVK G F +PHF + Q ++ I+V+ +R
Sbjct: 214 PFDDDNLRQLLEKVKRGVFH-IPHFVPPDCQSLLRGMIEVNPDRR 257
>Hs14754789 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 257
Score = 94.0 bits (232), Expect = 4e-19
Identities = 71/233 (30%), Positives = 113/233 (48%), Gaps = 47/233 (20%)
Query: 12 LLEEIGRGSFGSVRKVVREADNKVMVR-KEVRYGHMNAKERQQLISECAILSQLKHDNIV 70
L E +G G++ +V K + D + +V K V +N + L++E IL ++H +IV
Sbjct: 59 LTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIV 118
Query: 71 EF--FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
+ F WD D ++L ME+C+ GDLS+ I H R+ +PE+ V R+ +Q L + +
Sbjct: 119 QLKDFQWDSD----NIYLIMEFCAGGDLSRFI----HTRRILPEK-VARVFMQQLASALQ 169
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
+ R++S H DLKP NI L+ + K
Sbjct: 170 FLHERNIS---------------------HLDLKPQNILLSSLE-------------KPH 195
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILY 241
+KL DFG A+ + E G+P YM+PE++ + Y D+WS+G ILY
Sbjct: 196 LKLADFGFAQHMSPWDE-KHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILY 247
>CE28643 [T] KOG0583 Serine/threonine protein kinase
Length = 564
Score = 94.0 bits (232), Expect = 4e-19
Identities = 82/290 (28%), Positives = 135/290 (46%), Gaps = 55/290 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y L E +G G+FG V+ + E K++ R++++ + K R+++ + LS
Sbjct: 25 YILKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQN----LSLF 80
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+H +I+ + + + +F+ ME+ S G+L I KH R E R QI+
Sbjct: 81 RHPHIIRLYQVI--STPSDIFMIMEHVSGGELFDYI--VKHGRLKTAEAR--RFFQQIIS 134
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
+ CH ++V+HRDLKP N+ L DE N
Sbjct: 135 GVDYCHR----------------------HMVVHRDLKPENLLL----DEQNN------- 161
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYEL 243
+K+ DFGL+ ++ +F T G+P Y +PEV+ + Y+ P D+WS G ILY L
Sbjct: 162 ----VKIADFGLS-NIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYAL 216
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
+PF + L K+K+G F P P F + + +++ + VD KR
Sbjct: 217 LCGTLPFDDEHVPSLFRKIKSGVF-PTPDFLERPIVNLLHHMLCVDPMKR 265
>CE07458 [T] KOG0583 Serine/threonine protein kinase
Length = 562
Score = 94.0 bits (232), Expect = 4e-19
Identities = 82/290 (28%), Positives = 135/290 (46%), Gaps = 55/290 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y L E +G G+FG V+ + E K++ R++++ + K R+++ + LS
Sbjct: 25 YILKETLGVGTFGKVKVGIHETTQYKVAVKILNRQKIKSLDVVGKIRREIQN----LSLF 80
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+H +I+ + + + +F+ ME+ S G+L I KH R E R QI+
Sbjct: 81 RHPHIIRLYQVI--STPSDIFMIMEHVSGGELFDYI--VKHGRLKTAEAR--RFFQQIIS 134
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
+ CH ++V+HRDLKP N+ L DE N
Sbjct: 135 GVDYCHR----------------------HMVVHRDLKPENLLL----DEQNN------- 161
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYEL 243
+K+ DFGL+ ++ +F T G+P Y +PEV+ + Y+ P D+WS G ILY L
Sbjct: 162 ----VKIADFGLS-NIMTDGDFLRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYAL 216
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
+PF + L K+K+G F P P F + + +++ + VD KR
Sbjct: 217 LCGTLPFDDEHVPSLFRKIKSGVF-PTPDFLERPIVNLLHHMLCVDPMKR 265
>7302570 [R] KOG0586 Serine/threonine protein kinase
Length = 702
Score = 94.0 bits (232), Expect = 4e-19
Identities = 79/285 (27%), Positives = 124/285 (42%), Gaps = 46/285 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L + IG+G+F V+ + K + +N + + E AIL L+H +I
Sbjct: 41 YELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHI 100
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ + + ++L EY G++ + + R PE R+ Q++ A+ C
Sbjct: 101 TRLY--EVMESQSMIYLVTEYAPNGEIFDHL--VANGRMKEPEAA--RVFTQLVSAVHYC 154
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H +G V+HRDLK N+ L D + N I
Sbjct: 155 H--------------------RRG--VVHRDLKAENVLL---DKDMN------------I 177
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
KL DFG + + T + G+P Y +PEV + Y P SDIWSLG +LY L +
Sbjct: 178 KLADFGFSNHYEEGATLKT-WCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGAL 236
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
PF KT EL+ +V G F +P F S+ + +I + V+ +R
Sbjct: 237 PFDGKTILELKSRVVLGKFR-IPFFMSQECEQLIRNMLVVEPDRR 280
>CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 795
Score = 94.0 bits (232), Expect = 4e-19
Identities = 76/263 (28%), Positives = 118/263 (43%), Gaps = 47/263 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK-ERQQLISECAILSQLKHDN 68
+ + +++G G++G V ++ + K ++ + +K + ++ E I+S L H N
Sbjct: 75 FEITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPN 134
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I++ + + + + L MEY S G+L Y + +PE RI QI A+
Sbjct: 135 IIQIYEVFEN--KDKIILVMEYSSGGELYD----YVSRCGSLPEAEARRIFRQITSAVLY 188
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH R V HRDLK NI L + N NA
Sbjct: 189 CHKHR----------------------VAHRDLKLENILL-----DQNNNA--------- 212
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLH 247
K+ DFGL+ A TT+ G+P Y SPE++ PY P D WSLG +LY L
Sbjct: 213 -KIADFGLSNYF-ADKNLLTTFCGSPLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGS 270
Query: 248 VPFQAKTYTELQGKVKAG-YFEP 269
+PF + + + ++K G YFEP
Sbjct: 271 MPFDGRDFNRMVRQIKRGAYFEP 293
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 93.6 bits (231), Expect = 5e-19
Identities = 77/300 (25%), Positives = 133/300 (43%), Gaps = 55/300 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ ++ E+G G+FG V K + + + K + + +E + + E IL+ H NI
Sbjct: 34 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVI--DTKSEEELEDYMVEIDILASCDHPNI 91
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ D N L++ +E+C+ G + ++ + + E + + Q L AL
Sbjct: 92 VKLL--DAFYYENNLWILIEFCAGGAVDAVMLELERP---LTESQIQVVCKQTLDALNYL 146
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + +IHRDLK GNI T D I
Sbjct: 147 HDNK----------------------IIHRDLKAGNILFTLDGD---------------I 169
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL-----RDQPYSPLSDIWSLGCILYELC 244
KL DFG++ +I+ +++GTPY+M+PEV+ +D+PY +D+WSLG L E+
Sbjct: 170 KLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMA 229
Query: 245 SLHVPFQAKTYTELQGKVKAGYFEP----LPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ P ++ +K EP P +S N +D + +C++ + R +T LL
Sbjct: 230 EIEPPHH--ELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLL 287
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 93.2 bits (230), Expect = 6e-19
Identities = 79/322 (24%), Positives = 145/322 (44%), Gaps = 63/322 (19%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHW 75
+G G+ GSV K + +K+ K + + + + ++Q+ E + + IV ++
Sbjct: 227 LGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGM 286
Query: 76 DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDL 135
D +++++++ MEY L + + + + E+ + +I +L L H +
Sbjct: 287 FTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKK-- 344
Query: 136 SKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFG 195
VIHRD+KP NI L N+N +KL DFG
Sbjct: 345 --------------------VIHRDIKPQNILL-------NENGQ--------VKLCDFG 369
Query: 196 LAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK-- 253
+ S +A ATT+ GT +YM+PE ++ QPYS SD+WSLG + E+ + P ++
Sbjct: 370 V--SGEAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKM 427
Query: 254 --------------TYT-ELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWS 298
T+T EL+ + ++ +S + + I C++ D +RPS
Sbjct: 428 AANIAPFELLMWILTFTPELKDEPESNI------IWSPSFKSFIDYCLKKDSRERPSPRQ 481
Query: 299 LLNDIQCR-ICRKALDLEKFER 319
++N + +K +++EKF R
Sbjct: 482 MINHPWIKGQMKKNVNMEKFVR 503
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 93.2 bits (230), Expect = 6e-19
Identities = 82/305 (26%), Positives = 134/305 (43%), Gaps = 51/305 (16%)
Query: 2 NRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAIL 61
+R Y + IGRG+FG V K V +++ K V H + ++ + L E L
Sbjct: 10 SRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSD-EDIELLAQEIFFL 68
Query: 62 SQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYV---PEEYVWRI 118
++LK I + + S +++ MEYC G S +++ R YV PEE V I
Sbjct: 69 AELKSPLITNYIATMLEDVS--MWIVMEYCGGGSCSDLLK-----RSYVNGLPEEKVSFI 121
Query: 119 MVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQN 178
+ ++ + L H R IHRD+K NI L
Sbjct: 122 IHEVTLGLKYLHEQRK----------------------IHRDIKAANILLN--------- 150
Query: 179 ASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL--RDQPYSPLSDIWSL 236
+ ++KLGDFG++ ++++++ T+VGTPY+M+PEV+ Y+ +DIWSL
Sbjct: 151 ------EEGMVKLGDFGVSGHIRSTLK-RDTFVGTPYWMAPEVVCCEVDGYNEKADIWSL 203
Query: 237 GCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPST 296
G YEL P ++ + L +S +D + C+ RPS
Sbjct: 204 GITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSA 263
Query: 297 WSLLN 301
++LL+
Sbjct: 264 YNLLS 268
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 93.2 bits (230), Expect = 6e-19
Identities = 80/287 (27%), Positives = 127/287 (43%), Gaps = 46/287 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHM-NAKERQQLISECAILSQLKHDN 68
+ + + +G+G FG V + ++ K + + +K +Q+ E I S L+H N
Sbjct: 118 FEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKN 177
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I+ + HD K ++L +E+ +G+L Q +R K + V +Y+++ M L L K
Sbjct: 178 ILRLYGHFHDEKR--IYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQ-MANALSYLHK 234
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H VIHRD+KP NI L G D E
Sbjct: 235 KH-------------------------VIHRDIKPENILL-GIDGE-------------- 254
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
IKL DFG S+ A TT GT Y+ PE++ + ++ D+WSLG + YE
Sbjct: 255 IKLSDFGW--SVHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAP 312
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
PF+ + K A +P F + +D+I+R +Q + KR S
Sbjct: 313 PFEDMSGHSATYKRIAKVDLKIPSFVPPDARDLISRLLQHNPEKRMS 359
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 93.2 bits (230), Expect = 6e-19
Identities = 77/313 (24%), Positives = 132/313 (41%), Gaps = 52/313 (16%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHW 75
+G+G+FG+V + + + + + K+V+ M + + E +L L H NIV++
Sbjct: 15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYR-- 72
Query: 76 DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDL 135
+++L + +EYC G L + + + +PE V Q+L L H
Sbjct: 73 GSYQTNDSLCIILEYCENGSLRSICKNFGK----IPENLVALYTFQVLQGLLYLH----- 123
Query: 136 SKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFG 195
++G VIHRD+K NI T IKL DFG
Sbjct: 124 ---------------NQG--VIHRDIKGANILTT---------------KDGTIKLADFG 151
Query: 196 LAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKTY 255
+A + A + + VG+PY+M+PEV+ + SDIWS+GC + EL + P+
Sbjct: 152 VATKINALEDHSV--VGSPYWMAPEVIELVGATTASDIWSVGCTVIELLDGNPPYYDLDP 209
Query: 256 TELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPST-------WSLLNDIQCRIC 308
T ++ PLP S + + +C Q D R T W ++N +
Sbjct: 210 TSALFRMVKDEHPPLPSNISSAAKSFLMQCFQKDPNLRIKTRKLLKHPWVIMNQTSSKFS 269
Query: 309 RKALDLEKFERHL 321
+++K+ +
Sbjct: 270 DAIDEVQKYNERV 282
>ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 488
Score = 93.2 bits (230), Expect = 6e-19
Identities = 85/304 (27%), Positives = 139/304 (44%), Gaps = 54/304 (17%)
Query: 5 ERQPTYRLLEEIGRGSFGSVRKVVREADN----KVMVRKEVRYGHMNAKERQQLISECAI 60
E Y L + +GRG++ E+ KV+ K+++ + K ++L SE AI
Sbjct: 35 EYHTKYMLKKLLGRGAYAQCYLAEIESGEQYAMKVVRLKDIK----SRKVHEKLESEIAI 90
Query: 61 LSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV 120
S+L + N+V+ + S +F+ +E C +G L +++ + + E +V R +
Sbjct: 91 HSKLDNPNVVKMYR--SFRSSEYVFMVLELCERGALDALLK----RNGKLKERHVARFVK 144
Query: 121 QILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNAS 180
Q + L H V+HRDLK GN+FL D +FN
Sbjct: 145 QTVEGLIYLH---------------------NSVSVVHRDLKLGNLFL---DSKFN---- 176
Query: 181 DVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL--RDQPYSPLSDIWSLGC 238
+K+GDFGL+ ++ E T GTP Y++PEVL + +S +DIWSLG
Sbjct: 177 --------VKIGDFGLSAVIKDG-EKKVTMCGTPNYIAPEVLFGKASGHSFEADIWSLGV 227
Query: 239 ILYELCSLHVPFQAKTYTELQGKVKA-GYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTW 297
I+Y L PFQ K ++ +K Y P S D+IT+ + + +RP+
Sbjct: 228 IIYTLLVGVPPFQKKNVEDIYKMIKLNNYIFPENCDLSSEAIDLITQILNTNPLERPTLE 287
Query: 298 SLLN 301
+L+
Sbjct: 288 HILS 291
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 93.2 bits (230), Expect = 6e-19
Identities = 85/299 (28%), Positives = 135/299 (44%), Gaps = 53/299 (17%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRY--GHMNAKE-RQQLISECAILSQLK 65
T++ + +G G+FG V K+ KEV+ +KE +QL E +L+QL
Sbjct: 213 TWKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINLLNQLC 272
Query: 66 HDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMA 125
H NIV+++ + TL +Y+EY S G + ++++ Y + V + Y QIL
Sbjct: 273 HPNIVQYY--GSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTR----QILAG 326
Query: 126 LFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYS 185
L H G +HRD+K NI + +
Sbjct: 327 LAYLH----------------------GRNTVHRDIKGANILVDPNGE------------ 352
Query: 186 KVIIKLGDFGLAKSLQASIEFAT--TYVGTPYYMSPEVLRDQP-YSPLSDIWSLGCILYE 242
IKL DFG+AK + A F+T ++ G+PY+M+PEV+ Q Y+ DIWSLGC + E
Sbjct: 353 ---IKLADFGMAKHVTA---FSTMLSFKGSPYWMAPEVVMSQNGYTHAVDIWSLGCTILE 406
Query: 243 LCSLHVPFQAKTYTELQGKVKAGYFEP-LPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ + P+ K+ P +P S + ++ I C+Q + T RP+ LL
Sbjct: 407 MATSKPPWSQFEGVAAIFKIGNSKDTPEIPDHLSNDAKNFIRLCLQRNPTVRPTASQLL 465
>SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 512
Score = 92.8 bits (229), Expect = 8e-19
Identities = 76/289 (26%), Positives = 136/289 (46%), Gaps = 55/289 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQL 64
+ L+ +G GSFG V V + KV+ +K++ ++ K+ + E ILS++
Sbjct: 201 FNFLQTLGTGSFGRVHLVQSNHNRLYYAIKVLEKKKI----VDMKQIEHTCDERYILSRV 256
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+H I + DAK+ LF+ M++ G+L ++R K R PE+ ++++
Sbjct: 257 QHPFITILWGTFQDAKN--LFMVMDFAEGGELFSLLR--KCHR--FPEKVAKFYAAEVIL 310
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
AL H+ + +++RDLKP N+ L D F
Sbjct: 311 ALDYLHHNQ----------------------IVYRDLKPENLLL----DRFGH------- 337
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELC 244
+K+ DFG AK + S T GTP Y++PE++ +PY+ +D WSLG +++E+
Sbjct: 338 ----LKIVDFGFAKRVSTSN--CCTLCGTPDYLAPEIISLKPYNKAADWWSLGILIFEML 391
Query: 245 SLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
+ + PF ++ +L + G P ++S D+++ +Q D T R
Sbjct: 392 AGYPPFYSENPMKLYENILEGKVN-YPSYFSPASIDLLSHLLQRDITCR 439
>Hs4502567_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 360
Score = 92.8 bits (229), Expect = 8e-19
Identities = 82/301 (27%), Positives = 127/301 (41%), Gaps = 43/301 (14%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK---ERQQLISECAILSQ 63
+ Y L E IG+G F VR+ + + K V + + L E +I
Sbjct: 9 EDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHM 68
Query: 64 LKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
LKH +IVE + + L++ E+ DL I E M QIL
Sbjct: 69 LKHPHIVELL--ETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQIL 126
Query: 124 MALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVD 183
AL CH +IHRD+KP + L +N++ V
Sbjct: 127 EALRYCHDNN----------------------IIHRDVKPHCVLLAS-----KENSAPV- 158
Query: 184 YSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
KLG FG+A L S A VGTP++M+PEV++ +PY D+W G IL+ L
Sbjct: 159 ------KLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFIL 212
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFY---SKNLQDIITRCIQVDFTKRPSTWSLL 300
S +PF +G +K G ++ P + S++ +D++ R + +D +R + + L
Sbjct: 213 LSGCLPFYGTKERLFEGIIK-GKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEAL 271
Query: 301 N 301
N
Sbjct: 272 N 272
>Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 357
Score = 92.4 bits (228), Expect = 1e-18
Identities = 81/287 (28%), Positives = 133/287 (46%), Gaps = 45/287 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ E +G G+F V +A K+ K + + KE + +E A+L ++KH+NI
Sbjct: 23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENI 81
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V D N L+L M+ S G+L I ++ + E+ ++ Q+L A++
Sbjct: 82 VALE--DIYESPNHLYLVMQLVSGGELFDRIV----EKGFYTEKDASTLIRQVLDAVYYL 135
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRDLKP N+ D+E SK++I
Sbjct: 136 HR----------------------MGIVHRDLKPENLLYYSQDEE----------SKIMI 163
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
DFGL+K ++ + +T GTP Y++PEVL +PYS D WS+G I Y L + P
Sbjct: 164 S--DFGLSK-MEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPP 220
Query: 250 FQAKTYTELQGKV-KAGYFEPLPHF--YSKNLQDIITRCIQVDFTKR 293
F + ++L ++ KA Y P++ S + +D I ++ D KR
Sbjct: 221 FYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKR 267
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 92.4 bits (228), Expect = 1e-18
Identities = 73/305 (23%), Positives = 129/305 (41%), Gaps = 51/305 (16%)
Query: 1 MNRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAI 60
+ R + Y L E+G+GS+GSV K R+ +V +V + +++ E +
Sbjct: 240 ITREDPTTKYEFLNELGKGSYGSVYK-ARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEM 298
Query: 61 LSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV 120
L Q H N+V + + L++ MEYC G ++ ++ + + Y+ R +
Sbjct: 299 LQQCNHPNVVRYL--GSYQGEDYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREAL 356
Query: 121 QILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNAS 180
+ L+ L +IY +HRD+K GNI LT +
Sbjct: 357 ------------KGLAYLHSIYK-------------VHRDIKGGNILLTEQGE------- 384
Query: 181 DVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCIL 240
+KLGDFG+A L ++ T++GTP++M+PEV+++ Y D+W+LG
Sbjct: 385 --------VKLGDFGVAAQLTRTMSKRNTFIGTPHWMAPEVIQENRYDGKVDVWALGVSA 436
Query: 241 YELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKN-----LQDIITRCIQVDFTKRPS 295
E+ P + + + EP P K D + +C+ + RP+
Sbjct: 437 IEMAEGLPPRSSVHPMRVLFMIS---IEPAPMLEDKEKWSLVFHDFVAKCLTKEPRLRPT 493
Query: 296 TWSLL 300
+L
Sbjct: 494 AAEML 498
>7299322 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 434
Score = 92.4 bits (228), Expect = 1e-18
Identities = 73/280 (26%), Positives = 129/280 (46%), Gaps = 48/280 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK-ERQQLISECAILSQLKHDN 68
+ +++++G+G++G V+ + + + + K ++ + A+ + ++ E I+S + H N
Sbjct: 82 FDIIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPN 141
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I+ + + + + L ME+ + G+L Y +RK + EE RI Q+ A++
Sbjct: 142 IIHIYEVFENREK--MVLVMEFAAGGELYD----YLSERKVLTEEEARRIFRQVATAVYY 195
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH + + HRDLK NI L D++ N
Sbjct: 196 CHKHK----------------------ICHRDLKLENILL---DEKGNA----------- 219
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLH 247
K+ DFGL+ T+ G+P Y SPE++ PY P D WSLG +LY L
Sbjct: 220 -KIADFGLSNVFDDQ-RLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGS 277
Query: 248 VPFQAKTYTELQGKVKAG-YFEP-LPHFYSKNLQDIITRC 285
+PF + L ++ G Y+EP P S ++D++T C
Sbjct: 278 MPFDGSNFKRLVKQISQGDYYEPRKPSRASTLIRDMLTVC 317
>Hs14770402 [R] KOG0586 Serine/threonine protein kinase
Length = 926
Score = 92.0 bits (227), Expect = 1e-18
Identities = 75/285 (26%), Positives = 124/285 (43%), Gaps = 46/285 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +G+G+F V+ + K + ++A +++ E I+ L H +I
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI 79
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
++ + + KS L+L EY G++ + + + W QIL A+ C
Sbjct: 80 IKLYQV-METKS-MLYLVTEYAKNGEIFDYLANHGRLNESEARRKFW----QILSAVDYC 133
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H G ++HRDLK N+ L D+ N I
Sbjct: 134 H----------------------GRKIVHRDLKAENLLL---DNNMN------------I 156
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
K+ DFG ++ E T+ G+P Y +PEV Q Y P DIWS+G +LY L +
Sbjct: 157 KIADFGFGNFFKSG-ELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGAL 215
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
PF T L+ +V G F +P+F S++ + +I R + +D +KR
Sbjct: 216 PFDGPTLPILRQRVLEGRFR-IPYFMSEDCEHLIRRMLVLDPSKR 259
>CE29318 [T] KOG0660 Mitogen-activated protein kinase
Length = 474
Score = 92.0 bits (227), Expect = 1e-18
Identities = 67/239 (28%), Positives = 113/239 (47%), Gaps = 45/239 (18%)
Query: 13 LEEIGRGSFGSVRK---VVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+E +G GSFG+V K V R+ + + K++R + +++ E +L ++HDNI
Sbjct: 121 IEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNI 180
Query: 70 V---EFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+ + + D + +++ E+ + + + + R+ + +E++ I+ QI+ AL
Sbjct: 181 ICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIKFIIYQIIRAL 240
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
H +IHRDLKPGN+ LT D
Sbjct: 241 KYIHSAN----------------------IIHRDLKPGNLALTDDSD------------- 265
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL--RDQPYSPLSDIWSLGCILYEL 243
+ + DFGLA+SL+ T YV T +Y SPEV+ + Y+ L+D+WSLGCI EL
Sbjct: 266 --LMILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKIDSYTNLADMWSLGCIAAEL 322
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 92.0 bits (227), Expect = 1e-18
Identities = 80/296 (27%), Positives = 133/296 (44%), Gaps = 55/296 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRY-GHMNAKER-----QQLISECAILSQLKHDNI 69
IGRG+FG+V + +++ K+V + +KE+ Q+L E +L L H NI
Sbjct: 74 IGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNI 133
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + + TL + +E+ G +S ++ + PE V Q+L+ L
Sbjct: 134 VRYLGTVRE--DETLNILLEFVPGGSISSLLEKFGA----FPESVVRTYTNQLLLGLEYL 187
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + ++HRD+K NI + NQ I
Sbjct: 188 H----------------------NHAIMHRDIKGANILVD------NQGC---------I 210
Query: 190 KLGDFGLAKSLQ--ASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
KL DFG +K + A+I A + GTPY+M+PEV+ +S +DIWS+GC + E+ +
Sbjct: 211 KLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGK 270
Query: 248 VPFQAKTYTELQGKVKAGYFE---PLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
P+ ++ Y E+ G + P+P S + D + +C+Q + RP+ LL
Sbjct: 271 APW-SQQYKEIAAIFHIGTTKSHPPIPDNISSDANDFLLKCLQQEPNLRPTASELL 325
>At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 347
Score = 91.7 bits (226), Expect = 2e-18
Identities = 85/312 (27%), Positives = 136/312 (43%), Gaps = 63/312 (20%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLIS-ECAILSQLKHD- 67
Y L EE+GRG+FG RK V ++ K K + + +E ++ + E I+ QL +
Sbjct: 28 YILGEELGRGNFGLTRKCVEKSTGKTFACKTILKTKLKDEECEEDVKREIRIMKQLSGEP 87
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
NIVEF + D +++ + MEYC G+L I K E+ I+ I+ +
Sbjct: 88 NIVEFKNAYED--KDSVHIVMEYCGGGELYDKILALYDVGKSYSEKEAAGIIRSIVNVVK 145
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CHY V+HRDLKP N LT DD NA+
Sbjct: 146 NCHY----------------------MGVMHRDLKPENFLLTSNDD----NAT------- 172
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+K+ DFG + ++ + G+ YY++PEVL+ Y +DIWS G ILY L
Sbjct: 173 -VKVIDFGCSVFIEEG-KVYQDLAGSDYYIAPEVLQGN-YGKEADIWSAGIILYILLCGK 229
Query: 248 VPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRI 307
PF + ++ ++K+ +++D+++ P W L + +
Sbjct: 230 SPFVKEPEGQMFNEIKS---------------------LEIDYSEEP--WPLRDSRAIHL 266
Query: 308 CRKALDLEKFER 319
++ LD ER
Sbjct: 267 VKRMLDRNPKER 278
>YKL101w [D] KOG0588 Serine/threonine protein kinase
Length = 1518
Score = 91.3 bits (225), Expect = 2e-18
Identities = 68/246 (27%), Positives = 117/246 (46%), Gaps = 47/246 (19%)
Query: 57 ECAILSQLKHDNIVEFFH-WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYV 115
E I+ + H N++ F W++ ++ L+L +EY G+L Y + +PE
Sbjct: 164 EIVIMKLISHTNVMALFEVWENKSE---LYLVLEYVDGGELFD----YLVSKGKLPEREA 216
Query: 116 WRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEF 175
QI+ + CH + + HRDLKP N+ L D+
Sbjct: 217 IHYFKQIVEGVSYCH----------------------SFNICHRDLKPENLLL----DKK 250
Query: 176 NQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIW 234
N+ IK+ DFG+A +L+ + T G+P+Y SPE++ +PY SD+W
Sbjct: 251 NRR----------IKIADFGMA-ALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVW 299
Query: 235 SLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRP 294
S G +L+ L + H+PF +L KV++G ++ +P S +D+I++ + +D KR
Sbjct: 300 SCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKYQ-MPSNLSSEARDLISKILVIDPEKRI 358
Query: 295 STWSLL 300
+T +L
Sbjct: 359 TTQEIL 364
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 91.3 bits (225), Expect = 2e-18
Identities = 76/281 (27%), Positives = 126/281 (44%), Gaps = 49/281 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKE--RQQLISECAILSQLKHDNIVEFF 73
+G+G FG+V + RE +K ++ +V + K QL E I S L+H NI+ +
Sbjct: 138 LGKGKFGNVY-LAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLY 196
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
+ HDA ++L +EY G + + ++ + E+ + +I AL CH R
Sbjct: 197 GYFHDA--TRVYLILEYAPLGTVYRELQ----KLSKFDEQRTANLYNRIANALSYCHSKR 250
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
VIHRD+KP N+ L + +K+ D
Sbjct: 251 ----------------------VIHRDIKPENLLLGSAGE---------------LKIAD 273
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG S+ A TT GT Y+ PE++ + + D+WSLG + YE PF+A
Sbjct: 274 FGW--SVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 331
Query: 254 TYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRP 294
TY E ++ F P F ++ +D+I+R ++ + ++RP
Sbjct: 332 TYQETYKRISRVEF-TFPDFVTEGARDLISRLLKHNPSQRP 371
>Hs5453966 [T] KOG0583 Serine/threonine protein kinase
Length = 552
Score = 91.3 bits (225), Expect = 2e-18
Identities = 82/290 (28%), Positives = 136/290 (46%), Gaps = 55/290 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y L + +G G+FG V+ + K++ R+++R + K ++++ + L
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQN----LKLF 71
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+H +I++ + + F+ MEY S G+L I KH R V E R+ QIL
Sbjct: 72 RHPHIIKLYQVI--STPTDFFMVMEYVSGGELFDYI--CKHGR--VEEMEARRLFQQILS 125
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
A+ CH ++V+HRDLKP N+ L + NA
Sbjct: 126 AVDYCHR----------------------HMVVHRDLKPENVLLDAH-----MNA----- 153
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYEL 243
K+ DFGL+ ++ + EF T G+P Y +PEV+ + Y+ P DIWS G ILY L
Sbjct: 154 -----KIADFGLS-NMMSDGEFLRTSCGSPNYTAPEVISGRLYAGPEVDIWSCGVILYAL 207
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
+PF + L K++ G F +P + ++++ ++ +QVD KR
Sbjct: 208 LCGTLPFDDEHVPTLFKKIRGGVFY-IPEYLNRSVATLLMHMLQVDPLKR 256
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 91.3 bits (225), Expect = 2e-18
Identities = 75/281 (26%), Positives = 126/281 (44%), Gaps = 49/281 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKE--RQQLISECAILSQLKHDNIVEFF 73
+G+G FG+V + RE +K ++ +V + K QL E I S L+H NI+ +
Sbjct: 139 LGKGKFGNVY-LAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLY 197
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
+ HDA ++L +EY G + + ++ + E+ + ++ AL CH R
Sbjct: 198 GYFHDA--TRVYLILEYAPLGTVYRELQ----KLSKFDEQRTATYITELANALSYCHSKR 251
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
VIHRD+KP N+ L + +K+ D
Sbjct: 252 ----------------------VIHRDIKPENLLLGSAGE---------------LKIAD 274
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG S+ A TT GT Y+ PE++ + + D+WSLG + YE PF+A
Sbjct: 275 FGW--SVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEAN 332
Query: 254 TYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRP 294
TY E ++ F P F ++ +D+I+R ++ + ++RP
Sbjct: 333 TYQETYKRISRVEF-TFPDFVTEGARDLISRLLKHNPSQRP 372
>YDR507c [D] KOG0588 Serine/threonine protein kinase
Length = 1142
Score = 90.9 bits (224), Expect = 3e-18
Identities = 86/312 (27%), Positives = 140/312 (44%), Gaps = 67/312 (21%)
Query: 10 YRLLEEIGRGSFGSVR-----KVVREADNKVMVRKEVRYGHMNAKE----------RQQL 54
++L E +G GS G V+ +EA KV+ + G+++ +
Sbjct: 19 WKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGI 78
Query: 55 ISECAILSQLKHDNIVEFFH-WDHDAKSNT-LFLYMEYCSKGDLSQMIRYYKHQRKYVPE 112
E I+ L H N++ + W+ +NT L+L +EY KG+L ++ +R +PE
Sbjct: 79 EREIIIMKLLNHPNVLRLYDVWE----TNTDLYLVLEYAEKGELFNLLV----ERGPLPE 130
Query: 113 EYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYD 172
R QI++ + CH ++HRDLKP N+ L D
Sbjct: 131 HEAIRFFRQIIIGVSYCH----------------------ALGIVHRDLKPENLLL---D 165
Query: 173 DEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPL-S 231
++N IK+ DFG+A +L+ + T G+P+Y +PE++ PY S
Sbjct: 166 HKYN------------IKIADFGMA-ALETEGKLLETSCGSPHYAAPEIVSGIPYQGFAS 212
Query: 232 DIWSLGCILYELCSLHVPFQAK--TYTELQGKVKAGYFE-PLPHFYSKNLQDIITRCIQV 288
D+WS G IL+ L + +PF + L KV+ G FE P S+ QD+I + + V
Sbjct: 213 DVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTV 272
Query: 289 DFTKRPSTWSLL 300
D +R T +L
Sbjct: 273 DPERRIKTRDIL 284
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 90.9 bits (224), Expect = 3e-18
Identities = 78/293 (26%), Positives = 124/293 (41%), Gaps = 47/293 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y E+IG+G+ G+V A + + K++ KE +I+E ++ +LK+ NI
Sbjct: 249 YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKEL--IINEILVMKELKNPNI 306
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V F D + LF+ MEY + G L+ ++ + + E + + + L AL
Sbjct: 307 VNFL--DSYLVGDELFVVMEYLAGGSLTDVVT----ETACMDEAQIAAVCRECLQALEFL 360
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + VIHRD+K N+ L G + +
Sbjct: 361 HANQ----------------------VIHRDIKSDNVLL-GMEGS--------------V 383
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFG + +T VGTPY+M+PEV+ + Y P DIWSLG + E+ P
Sbjct: 384 KLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPP 443
Query: 250 FQAKTYTELQGKVKAGYFEPL--PHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ + + L P S +D + RC+++D KR S LL
Sbjct: 444 YLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELL 496
>CE18169 [T] KOG0603 Ribosomal protein S6 kinase
Length = 797
Score = 90.9 bits (224), Expect = 3e-18
Identities = 75/276 (27%), Positives = 129/276 (46%), Gaps = 47/276 (17%)
Query: 10 YRLLEEIGRGSFGSV---RKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ LL+ +G+GSFG V RKV V K ++ + ++RQ+ E IL+ + H
Sbjct: 104 FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISH 163
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
IV+ H+ + L+L +++ GDL + + E+ V + ++ +AL
Sbjct: 164 PFIVKL-HYAFQTEGK-LYLILDFLRGGDLFTRLS----KEVMFTEDDVKFYLAELTLAL 217
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
E L S G +++RDLKP NI L D D
Sbjct: 218 --------------------EHLHSLG--IVYRDLKPENILL------------DADGH- 242
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
IK+ DFGL+K S + ++ GT YM+PEV+ + +S +D WSLG +++E+ +
Sbjct: 243 --IKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTG 300
Query: 247 HVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDII 282
H+PFQ + + ++ +PHF ++ Q ++
Sbjct: 301 HLPFQGRDRNDTMTQILKAKLS-MPHFLTQEAQSLL 335
Score = 67.8 bits (164), Expect = 3e-11
Identities = 68/290 (23%), Positives = 113/290 (38%), Gaps = 49/290 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +LE+IG G+ V K +A + K V+ +A E ++ L H +
Sbjct: 454 YEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDIL-----LRHSHHQFV 508
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F D +++ E C G+L + +++ E+ V IM +L A+
Sbjct: 509 VKLFDVYED--ETAIYMIEELCEGGELLDKL---VNKKSLGSEKEVAAIMANLLNAVQYL 563
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + V HRDL NI D + + +
Sbjct: 564 HSQQ----------------------VAHRDLTAANILFALKDGDPSS-----------L 590
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
++ DFG AK +A T T +++PEVLR Q Y D+WSLG +L+ + + P
Sbjct: 591 RIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTP 650
Query: 250 F------QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
F + G K P+ S +D++ + + VD +R
Sbjct: 651 FAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRR 700
>CE13014 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 90.9 bits (224), Expect = 3e-18
Identities = 75/276 (27%), Positives = 129/276 (46%), Gaps = 47/276 (17%)
Query: 10 YRLLEEIGRGSFGSV---RKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ LL+ +G+GSFG V RKV V K ++ + ++RQ+ E IL+ + H
Sbjct: 47 FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISH 106
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
IV+ H+ + L+L +++ GDL + + E+ V + ++ +AL
Sbjct: 107 PFIVKL-HYAFQTEGK-LYLILDFLRGGDLFTRLS----KEVMFTEDDVKFYLAELTLAL 160
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
E L S G +++RDLKP NI L D D
Sbjct: 161 --------------------EHLHSLG--IVYRDLKPENILL------------DADGH- 185
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
IK+ DFGL+K S + ++ GT YM+PEV+ + +S +D WSLG +++E+ +
Sbjct: 186 --IKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTG 243
Query: 247 HVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDII 282
H+PFQ + + ++ +PHF ++ Q ++
Sbjct: 244 HLPFQGRDRNDTMTQILKAKLS-MPHFLTQEAQSLL 278
Score = 67.8 bits (164), Expect = 3e-11
Identities = 68/290 (23%), Positives = 113/290 (38%), Gaps = 49/290 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +LE+IG G+ V K +A + K V+ +A E ++ L H +
Sbjct: 397 YEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDIL-----LRHSHHQFV 451
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F D +++ E C G+L + +++ E+ V IM +L A+
Sbjct: 452 VKLFDVYED--ETAIYMIEELCEGGELLDKL---VNKKSLGSEKEVAAIMANLLNAVQYL 506
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + V HRDL NI D + + +
Sbjct: 507 HSQQ----------------------VAHRDLTAANILFALKDGDPSS-----------L 533
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
++ DFG AK +A T T +++PEVLR Q Y D+WSLG +L+ + + P
Sbjct: 534 RIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTP 593
Query: 250 F------QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
F + G K P+ S +D++ + + VD +R
Sbjct: 594 FAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRR 643
>At5g41990 [R] KOG0584 Serine/threonine protein kinase
Length = 608
Score = 90.9 bits (224), Expect = 3e-18
Identities = 85/308 (27%), Positives = 137/308 (43%), Gaps = 55/308 (17%)
Query: 5 ERQPTYRLL---EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQ--QLISECA 59
E+ P+ R + + +GRG+F +V K E D + V + Q +L SE
Sbjct: 66 EKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVH 125
Query: 60 ILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIM 119
+L LKH+NI++ F+ D K+ T+ + E + G L R Y+ + + V + +
Sbjct: 126 LLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSL----RVYRKKHRKVDPKAIKNWA 181
Query: 120 VQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNA 179
QIL L H S+ VIHRDLK NIF+ G E
Sbjct: 182 RQILKGLNYLH--------------------SQNPPVIHRDLKCDNIFVNGNTGE----- 216
Query: 180 SDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCI 239
+K+GD GLA LQ A + +GTP +M+PE L ++ Y+ L DI+S G
Sbjct: 217 ---------VKIGDLGLATVLQQPT--ARSVIGTPEFMAPE-LYEEEYNELVDIYSFGMC 264
Query: 240 LYELCSLHVPF-----QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRP 294
+ E+ + P+ QA+ Y ++ +K + L ++ I +C+ + + RP
Sbjct: 265 MLEMVTCEYPYNECRNQAQIYKKVTSNIKP---QSLGKVDDPQVRQFIEKCL-LPASSRP 320
Query: 295 STWSLLND 302
+ L D
Sbjct: 321 TALELSKD 328
>At4g08470 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 560
Score = 90.9 bits (224), Expect = 3e-18
Identities = 82/293 (27%), Positives = 133/293 (44%), Gaps = 55/293 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER---QQLISECAILSQLKHDNIVEF 72
+GRGS+ SV + + E D KEV + + QQL E A+LSQL+H NIV +
Sbjct: 309 LGRGSYASVYEAISE-DGDFFAVKEVSLLDKGIQAQECIQQLEGEIALLSQLQHQNIVRY 367
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
D L++++E ++G + ++ Y ++Q Y R QIL L H
Sbjct: 368 RGTAKDVSK--LYIFLELVTQGSVQKL--YERYQLSYTVVSLYTR---QILAGLNYLH-- 418
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
KG+V HRD+K N+ + + +KL
Sbjct: 419 ------------------DKGFV--HRDIKCANMLVD---------------ANGTVKLA 443
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLR----DQPYSPLSDIWSLGCILYELCSLHV 248
DFGLA++ + + GT ++M+PEV+ D SP +DIWSLGC + E+C+ +
Sbjct: 444 DFGLAEA--SKFNDIMSCKGTLFWMAPEVINRKDSDGNGSP-ADIWSLGCTVLEMCTGQI 500
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
P+ + K+ G +P S + + I C++V+ +RP+ LL+
Sbjct: 501 PYSDLKPIQAAFKIGRGTLPDVPDTLSLDARHFILTCLKVNPEERPTAAELLH 553
>SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 90.5 bits (223), Expect = 4e-18
Identities = 84/319 (26%), Positives = 128/319 (39%), Gaps = 50/319 (15%)
Query: 13 LEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEF 72
+ +G G GSVRK + K V N ++QL+ E I IV++
Sbjct: 82 MNSLGEGVSGSVRKCRIRGTQMIFAMKTV-LAAPNTALQKQLLRELKINRSCTSPYIVKY 140
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
+ ++ L + MEYC G L + + + Q E + +I +L L H
Sbjct: 141 YGACYNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGRTGERPLGKIAFGVLSGLSYLHDR 200
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
+ +IHRD+KP NI LT SK +KL
Sbjct: 201 K----------------------IIHRDIKPSNILLT---------------SKGQVKLC 223
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQA 252
DFG++ L S+ A T+ GT YYM+PE + Y+ SDIWSLG L E+ PF
Sbjct: 224 DFGVSGELVNSL--AGTFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFPFPP 281
Query: 253 KTYTELQGKVKAGYFEPLPH---------FYSKNLQDIITRCIQVDFTKRPSTWSLLNDI 303
+ Y +P +SK+ Q + C+ D T+RP +L
Sbjct: 282 EGSPPPMPIELLSYIINMPPPLLPQEPGIKWSKSFQHFLCVCLDKDKTRRPGPQKMLTHP 341
Query: 304 QCRICRKA-LDLEKFERHL 321
+ + +D+E+F R +
Sbjct: 342 WVKAFERIHVDMEEFLRQV 360
>CE27297 [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 476
Score = 90.5 bits (223), Expect = 4e-18
Identities = 84/310 (27%), Positives = 142/310 (45%), Gaps = 55/310 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEV------RYGHMNAKERQQLISECAILSQLKHDNI 69
+G+G FG V +++D V+ K++ R AK R + +E ++ +L H NI
Sbjct: 176 LGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRD-IRNEVEVMKKLSHPNI 234
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + W AK + ++ +EY G+ + K+ R + E Q++ A+
Sbjct: 235 VAIYDWITVAKYS--YMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYL 292
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H S G + HRD+KP NI + + + I+
Sbjct: 293 H--------------------SVG--ICHRDIKPENILCSDKAE------------RCIL 318
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQ--PYSPLSDIWSLGCILYELCSLH 247
KL DFG+AK+ S+ T GTP Y +PE++ ++ Y+P DIWSLGC+L+ S +
Sbjct: 319 KLTDFGMAKN---SVNRMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSLGCVLFITFSGY 375
Query: 248 VPFQAKTYTE--LQGKVKAG--YFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND- 302
PF ++ YT+ + +V G F + Q++I + V+ + RPS L++
Sbjct: 376 PPF-SEEYTDMTMDEQVLTGRLIFHAQWRRITVETQNMIKWMLTVEPSNRPSAVELMSTQ 434
Query: 303 -IQCRICRKA 311
++C CR A
Sbjct: 435 WMKCADCRTA 444
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 90.5 bits (223), Expect = 4e-18
Identities = 75/297 (25%), Positives = 130/297 (43%), Gaps = 51/297 (17%)
Query: 12 LLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVE 71
+++ IG+GS G V+ V + + K ++ +++ R+ + E I + N+V
Sbjct: 72 MVKVIGKGSSGVVQLVQHKWTGQFFALKVIQL-NIDEAIRKAIAQELKINQSSQCPNLVT 130
Query: 72 FFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHY 131
+ +D + + L +EY G L+ ++ K +P+ Y+ I Q+L L H+
Sbjct: 131 SYQSFYD--NGAISLILEYMDGGSLADFLKSVKA----IPDSYLSAIFRQVLQGLIYLHH 184
Query: 132 GRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKL 191
R +IHRDLKP N+ + + +K+
Sbjct: 185 DRH---------------------IIHRDLKPSNLLINHRGE---------------VKI 208
Query: 192 GDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPF- 250
DFG++ + + A T+VGT YMSPE + Y SDIWSLG ++ E + P+
Sbjct: 209 TDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYA 268
Query: 251 ---QAKTYTELQGKVKAGYFEPLPHF----YSKNLQDIITRCIQVDFTKRPSTWSLL 300
Q +T+T + ++A +P P +S L I+ C+Q D R S L+
Sbjct: 269 PPNQEETWTSVFELMEAIVDQPPPALPSGNFSPELSSFISTCLQKDPNSRSSAKELM 325
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 90.1 bits (222), Expect = 5e-18
Identities = 79/293 (26%), Positives = 133/293 (44%), Gaps = 46/293 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
++ E IGRG FG V K +V K + ++ E + + E L+ LK +
Sbjct: 23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDS-DSDEVEDVQREIQFLASLKQISN 81
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ ++ + K +L++ ME+C+ G L ++R K + E+Y+ IM ++L+AL KC
Sbjct: 82 ITRYYGSY-LKDTSLWIIMEHCAGGSLRSLLRPGK-----IDEKYIGVIMRELLVAL-KC 134
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
+ + VIHRD+K N+ +T + +
Sbjct: 135 IHKDN---------------------VIHRDIKAANVLITNEGN---------------V 158
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLS-DIWSLGCILYELCSLHV 248
KL DFG+A + + T GTPY+M+PEV+ + Y DIWSLG YE+ + +
Sbjct: 159 KLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNP 218
Query: 249 PF-QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
P+ + +Q +K+ YS +L++ I C+ D +R S LL
Sbjct: 219 PYCDVEALRAMQLIIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLL 271
>YCL024w [T] KOG0583 Serine/threonine protein kinase
Length = 1037
Score = 90.1 bits (222), Expect = 5e-18
Identities = 80/298 (26%), Positives = 132/298 (43%), Gaps = 59/298 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNK----VMVRKEVRYGHMNAKERQQLIS-----ECAI 60
++L E +G GS G V+ E ++ K + + N ++ E I
Sbjct: 21 WKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVI 80
Query: 61 LSQLKHDNIVEFFH-WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIM 119
+ L H N++ + W+ +N L+L +EY KG+L ++ + +PE
Sbjct: 81 MKLLSHPNVLSLYDVWE---TNNNLYLILEYAEKGELFNLLVDHGP----LPEREAINCF 133
Query: 120 VQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNA 179
QI++ + CH ++HRDLKP N+ L D +N
Sbjct: 134 RQIIIGISYCH----------------------ALGIVHRDLKPENLLL---DSFYN--- 165
Query: 180 SDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPL-SDIWSLGC 238
IK+ DFG+A +LQ + T G+P+Y +PE++ PY SD+WS G
Sbjct: 166 ---------IKIADFGMA-ALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGV 215
Query: 239 ILYELCSLHVPFQAK--TYTELQGKVKAGYFE-PLPHFYSKNLQDIITRCIQVDFTKR 293
IL+ L + +PF + +L KV+ G FE P S++ QD+I + + VD +R
Sbjct: 216 ILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQR 273
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 90.1 bits (222), Expect = 5e-18
Identities = 83/307 (27%), Positives = 132/307 (42%), Gaps = 50/307 (16%)
Query: 2 NRNERQPT-YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRY---GHMNAKERQQLISE 57
+R+ R PT +RL + +G+G+FG V + + K+V++ +KE L E
Sbjct: 346 SRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECE 405
Query: 58 CAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWR 117
+L H+ IV+++ D + TL ++MEY G + ++ Y + +Y +
Sbjct: 406 IQLLKNFLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQ 465
Query: 118 IMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQ 177
I+ + HY L S +++HRD+K NI +
Sbjct: 466 ILEGV-------HY-----------------LHSN--MILHRDIKGANILRDSTGN---- 495
Query: 178 NASDVDYSKVIIKLGDFGLAKSLQASIEFAT---TYVGTPYYMSPEVLRDQPYSPLSDIW 234
+KLGDFG +K LQ T + GTPY+MSPEV+ Q Y +DIW
Sbjct: 496 -----------VKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGQGYGRKADIW 544
Query: 235 SLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEP-LPHFYSKNLQDIITRCIQVDFTKR 293
S+ C + E+ + P+ K+ P LP S +D + R I V+ R
Sbjct: 545 SVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKR-IFVEAKLR 603
Query: 294 PSTWSLL 300
PS LL
Sbjct: 604 PSADELL 610
>Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 1030
Score = 90.1 bits (222), Expect = 5e-18
Identities = 64/235 (27%), Positives = 107/235 (45%), Gaps = 44/235 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ +L +G G++G V K + ++++ K+ + N + ++ + E +L LK +NI
Sbjct: 13 FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI 72
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
VE + + L+L EY K M+ + VP E V + Q++ A+ C
Sbjct: 73 VELK--EAFRRRGKLYLVFEYVEKN----MLELLEEMPNGVPPEKVKSYIYQLIKAIHWC 126
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRD+KP N+ ++ D ++
Sbjct: 127 HKND----------------------IVHRDIKPENLLISHND---------------VL 149
Query: 190 KLGDFGLAKSL-QASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
KL DFG A++L + + T YV T +Y SPE+L PY D+WS+GCIL EL
Sbjct: 150 KLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGEL 204
>Hs20545357 [T] KOG0583 Serine/threonine protein kinase
Length = 436
Score = 90.1 bits (222), Expect = 5e-18
Identities = 78/294 (26%), Positives = 130/294 (43%), Gaps = 46/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YR+ EIG G+F V+ + + + K + ++ K ++ L E + + +L H NI
Sbjct: 74 YRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQKTQRLLSREISSMEKLHHPNI 133
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ + L L MEY G+L I + PE + I QI+ A+
Sbjct: 134 IRLYEVVETLSK--LHLVMEYAGGGELFGKIS--TEGKLSEPESKL--IFSQIVSAVKHM 187
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + +IHRDLK N+F T S +
Sbjct: 188 HENQ----------------------IIHRDLKAENVFYT---------------SNTCV 210
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLS-DIWSLGCILYELCSLHV 248
K+GDFG + ++ E T+ G+P Y +PE+ RD+ Y + DIW+LG +LY + + +
Sbjct: 211 KVGDFGFS-TVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTM 269
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF+A+T +L+ + G + PH S+ +I +Q T+R ++ND
Sbjct: 270 PFRAETVAKLKKSILEGTYSVPPH-VSEPCHRLIRGVLQQIPTERYGIDCIMND 322
>CE20258 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 353
Score = 90.1 bits (222), Expect = 5e-18
Identities = 70/235 (29%), Positives = 106/235 (44%), Gaps = 45/235 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L ++G GS+G V K +++ K+ + ++ + E +L QLKH N+
Sbjct: 4 YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQLKHQNL 63
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + ++ L L E C + L ++ + V +E + +I+ Q+L AL C
Sbjct: 64 VGLI--EVFKRNRKLHLVFELCDRTVLHEL----EKNPHGVNDELIKKIIYQLLEALKFC 117
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + IHRD+KP NIFLT D +
Sbjct: 118 H----------------------SHKCIHRDVKPENIFLTRNDQ---------------V 140
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL-RDQPYSPLSDIWSLGCILYEL 243
KLGDFG A+ + + E T YV T +Y SPE+L D Y P DIW++GC+ EL
Sbjct: 141 KLGDFGFARIINTT-EMYTDYVATRWYRSPELLVGDVQYGPPVDIWAVGCVYAEL 194
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 90.1 bits (222), Expect = 5e-18
Identities = 79/303 (26%), Positives = 138/303 (45%), Gaps = 55/303 (18%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYG-HMNAKER-----QQLISECAILS 62
++R + IGRG+FG+V + +++ K+V + +KE+ Q+L E +L
Sbjct: 68 SWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLK 127
Query: 63 QLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
L H NIV + + +TL + +E+ G +S ++ + PE V Q+
Sbjct: 128 NLSHPNIVRYLGTVRE--DDTLNILLEFVPGGSISSLLEKFGP----FPESVVRTYTRQL 181
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
L+ L H + ++HRD+K NI +
Sbjct: 182 LLGLEYLH----------------------NHAIMHRDIKGANILVD------------- 206
Query: 183 DYSKVIIKLGDFGLAKSLQ--ASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCIL 240
+K IKL DFG +K + A++ A + GTPY+M+PEV+ +S +DIWS+GC +
Sbjct: 207 --NKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTV 264
Query: 241 YELCSLHVPFQAKTYTELQGKVKAGYFE---PLPHFYSKNLQDIITRCIQVDFTKRPSTW 297
E+ + P+ ++ Y E+ G + P+P S + +D + +C+Q RP+
Sbjct: 265 IEMVTGKAPW-SQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKCLQEVPNLRPTAS 323
Query: 298 SLL 300
LL
Sbjct: 324 ELL 326
>SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 436
Score = 89.7 bits (221), Expect = 7e-18
Identities = 74/286 (25%), Positives = 134/286 (45%), Gaps = 51/286 (17%)
Query: 6 RQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGH--MNAKERQQLISECAILSQ 63
R ++ L +GRGS+G V V ++ ++ +K+++ + AK +Q +E IL +
Sbjct: 87 RPADFQPLTVLGRGSYGKVLLVKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEE 146
Query: 64 LKHDNIVEFFH--WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
++H I ++ DHD L+L ++Y G+L + +++ +PE+ V +
Sbjct: 147 VRHPFICRLYYAFQDHDR----LYLILQYAPGGELFSHLA----EQRMLPEDVVAFYTAE 198
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
+ +AL H KL +Y RDLKP N L D E +
Sbjct: 199 LTLALIHLH------KLGIVY----------------RDLKPENCLL---DAEGH----- 228
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILY 241
I L DFGL+K + + ++VGT Y +PE+L +QPY D WS+G +++
Sbjct: 229 -------ILLTDFGLSKVAENGAD-CRSFVGTEEYCAPEILLEQPYDHAVDWWSMGILIF 280
Query: 242 ELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQ 287
+L + PF A + + K+ +P + + + +DII + ++
Sbjct: 281 DLLTGSPPFTANNHKRIMEKITRAK-PNIPFYVTSDARDIINKFLK 325
>Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 89.7 bits (221), Expect = 7e-18
Identities = 81/291 (27%), Positives = 131/291 (44%), Gaps = 50/291 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFH- 74
IG G+F V++ + K + + KE + SE I+ L H NIV+
Sbjct: 290 IGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKE-DMVDSEILIIQSLSHPNIVKLHEV 348
Query: 75 WDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRD 134
++ D + ++L +EY GDL I + PE +++ + AL H D
Sbjct: 349 YETDME---IYLILEYVQGGDLFDAII----ESVKFPEPDAALMIMDLCKALVHMH---D 398
Query: 135 LSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDF 194
S ++HRDLKP N+ + +D+ +KL DF
Sbjct: 399 KS-------------------IVHRDLKPENLLVQRNEDK-----------STTLKLADF 428
Query: 195 GLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQA-- 252
GLAK + I T GTP Y++PE+L ++ Y D+W+ G ILY L PF++
Sbjct: 429 GLAKHVVRPI---FTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPE 485
Query: 253 KTYTELQGKVKAGYFEPLPHFY---SKNLQDIITRCIQVDFTKRPSTWSLL 300
+ EL ++ G+FE LP ++ S +D+++R + VD KR + +L
Sbjct: 486 RDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVL 536
>CE16081 [T] KOG0583 Serine/threonine protein kinase
Length = 334
Score = 89.7 bits (221), Expect = 7e-18
Identities = 75/301 (24%), Positives = 134/301 (43%), Gaps = 46/301 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
YRL +E+G G+F V+ V + + + K + M+AK ++ L E + ++ H NI
Sbjct: 49 YRLGKELGAGNFSKVKLGVHQLTKEKVAVKIMDKAKMDAKAQKLLSREIQAMEEMNHPNI 108
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V+ F + + L +EY S G+L Y H+R + E + QI+ A+
Sbjct: 109 VKLF--EVVETLTRVHLVIEYASGGELYT----YVHERGKLTEGDAKPLFAQIVSAVSHM 162
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H ++HRD+K N+ + S +
Sbjct: 163 HSRN----------------------IVHRDIKAENVMFS---------------SPNTV 185
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLHV 248
KL DFG + L + T+ G+P Y +PE+ +D Y+ L D+W+LG +L+ +
Sbjct: 186 KLVDFGFS-CLVDREQMLRTFCGSPPYAAPELFQDTSYAGELVDVWALGVLLFFMLIGVT 244
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRIC 308
PF+A+T +++ + AG ++ +P + S ++I ++ D +R S+ R C
Sbjct: 245 PFKAETVPDMKVLITAGKYQ-IPDYVSLLATELIKSMLKTDTGQRADIDSVKKHFWMRDC 303
Query: 309 R 309
R
Sbjct: 304 R 304
>CE00847 [T] KOG0583 Serine/threonine protein kinase
Length = 622
Score = 89.7 bits (221), Expect = 7e-18
Identities = 79/296 (26%), Positives = 131/296 (43%), Gaps = 47/296 (15%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER-QQLISECAILSQLKHDNIVEF 72
E IG+G+FG+V++ + K + G M + +E L +L H +I
Sbjct: 28 ETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRMKGLGTVNKTRNEIDNLQKLTHPHITRL 87
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
F + + +FL ME S G+L I ++ +P R QI+ + CH
Sbjct: 88 FRVI--STPSDIFLVMELVSGGELFSYIT----RKGALPIRESRRYFQQIISGVSYCH-- 139
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
++++HRDLKP N+ L + N+N IK+
Sbjct: 140 --------------------NHMIVHRDLKPENLLL-----DANKN----------IKIA 164
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLHVPFQ 251
DFGL+ + + +T G+P Y +PE++ ++ Y P D+WS G ILY + +PF
Sbjct: 165 DFGLSNYMTDG-DLLSTACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLPFD 223
Query: 252 AKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRI 307
+ L K+K+G + +P+ K D+I+ +QVD KR ++N RI
Sbjct: 224 DQNVPTLFAKIKSGRY-TVPYSMEKQAADLISTMLQVDPVKRADVKRIVNHSWFRI 278
>At2g26980 [T] KOG0583 Serine/threonine protein kinase
Length = 441
Score = 89.7 bits (221), Expect = 7e-18
Identities = 84/315 (26%), Positives = 137/315 (42%), Gaps = 62/315 (19%)
Query: 1 MNRNE----RQPTYRLLEEIGRGSFGSVRKVVREADN------KVMVRKEVRYGHMNAKE 50
MNR + R Y + IG G+F V K R ++ K++ +++V + K
Sbjct: 1 MNRRQQVKRRVGKYEVGRTIGEGTFAKV-KFARNSETGEPVALKILDKEKV----LKHKM 55
Query: 51 RQQLISECAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYV 110
+Q+ E A + +KH N+V+ + + A +F+ +EY + G+L I +
Sbjct: 56 AEQIRREIATMKLIKHPNVVQLY--EVMASKTKIFIILEYVTGGELFDKIVNDGRMK--- 110
Query: 111 PEEYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTG 170
E+ R Q++ A+ CH S+G V HRDLKP N+ L
Sbjct: 111 -EDEARRYFQQLIHAVDYCH--------------------SRG--VYHRDLKPENLLLDS 147
Query: 171 YDDEFNQNASDVDYSKVIIKLGDFGLAKSLQASIE--FATTYVGTPYYMSPEVLRDQPYS 228
Y + +K+ DFGL+ Q + T GTP Y++PEVL D+ Y
Sbjct: 148 YGN---------------LKISDFGLSALSQQVRDDGLLHTSCGTPNYVAPEVLNDRGYD 192
Query: 229 -PLSDIWSLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQ 287
+D+WS G +LY L + ++PF L K+ +G F P + S +ITR +
Sbjct: 193 GATADMWSCGVVLYVLLAGYLPFDDSNLMNLYKKISSGEFN-CPPWLSLGAMKLITRILD 251
Query: 288 VDFTKRPSTWSLLND 302
+ R + + D
Sbjct: 252 PNPMTRVTPQEVFED 266
>At1g29230 [T] KOG0583 Serine/threonine protein kinase
Length = 520
Score = 89.7 bits (221), Expect = 7e-18
Identities = 77/282 (27%), Positives = 126/282 (44%), Gaps = 45/282 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVR-EADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
Y L + +G G+F V ++ +KV ++ + M + + E +IL +++H
Sbjct: 74 YELGKLLGHGTFAKVYLAQNIKSGDKVAIKVIDKEKIMKSGLVAHIKREISILRRVRHPY 133
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
IV F + A + ++ MEY G+L + + +PEE R Q++ ++
Sbjct: 134 IVHLF--EVMATKSKIYFVMEYVGGGELFNTVA-----KGRLPEETARRYFQQLISSVSF 186
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH G V HRDLKP N+ L D++ N SD S V
Sbjct: 187 CH----------------------GRGVYHRDLKPENLLL---DNKGNLKVSDFGLSAVA 221
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPL-SDIWSLGCILYELCSLH 247
+L GL T+ GTP Y++PEVL + Y +D+WS G IL+ L + H
Sbjct: 222 EQLRQDGLCH----------TFCGTPAYIAPEVLTRKGYDAAKADVWSCGVILFVLMAGH 271
Query: 248 VPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVD 289
+PF K + K+ G F P ++S +L ++TR + +
Sbjct: 272 IPFYDKNIMVMYKKIYKGEFR-CPRWFSSDLVRLLTRLLDTN 312
>Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 912
Score = 89.4 bits (220), Expect = 9e-18
Identities = 99/358 (27%), Positives = 149/358 (40%), Gaps = 71/358 (19%)
Query: 14 EEIGRGSFGSV-----RKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
E +G G FG V RK R+ K++ ++R+ K+ QL +E AIL L H
Sbjct: 587 EVLGSGQFGIVYGGKHRKTGRDVAIKII--DKLRFP---TKQESQLRNEVAILQNLHHPG 641
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
+V + +F+ ME GD+ +MI ++ +PE ++ QIL+AL
Sbjct: 642 VVNLECMFETPER--VFVVMEKLH-GDMLEMI--LSSEKGRLPEHITKFLITQILVALRH 696
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H+ ++H DLKP N+ L D F Q
Sbjct: 697 LHFKN----------------------IVHCDLKPENVLLASADP-FPQ----------- 722
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KL DFG A+ + F + VGTP Y++PEVLR++ Y+ D+WS+G I+Y S
Sbjct: 723 VKLCDFGFARIIGEK-SFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTF 781
Query: 249 PFQAKTYTELQGKVKAGYFEPLP-HFYSKNLQDIITRCIQVDFTKRPS------------ 295
PF Q + A + P P S D+I +QV KR S
Sbjct: 782 PFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQD 841
Query: 296 --TWSLLNDIQCRICRKALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVD 351
TW L +++C+I + + E + Y GE Q+ T + AS D
Sbjct: 842 YQTWLDLRELECKIGERYITHESDDLRWEKY------AGEQRLQYPTHLINPSASHSD 893
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 89.4 bits (220), Expect = 9e-18
Identities = 83/307 (27%), Positives = 133/307 (43%), Gaps = 50/307 (16%)
Query: 2 NRNERQPT-YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRY---GHMNAKERQQLISE 57
+R+ R PT +RL + +G+G+FG V + + K+V++ +KE L E
Sbjct: 348 SRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECE 407
Query: 58 CAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWR 117
+L L H+ IV+++ D + TL ++MEY G + ++ Y + V +Y +
Sbjct: 408 IQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQ 467
Query: 118 IMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQ 177
I+ + HY L S +++ RD+K NI +
Sbjct: 468 ILEGV-------HY-----------------LHSN--MIVLRDIKGANILRDSTGN---- 497
Query: 178 NASDVDYSKVIIKLGDFGLAKSLQASIEFAT---TYVGTPYYMSPEVLRDQPYSPLSDIW 234
+KLGDFG +K LQ T + GTPY+MSPEV+ + Y +DIW
Sbjct: 498 -----------VKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIW 546
Query: 235 SLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEP-LPHFYSKNLQDIITRCIQVDFTKR 293
S+ C + E+ + P+ K+ P LP S +D + R I V+ R
Sbjct: 547 SVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKR-IFVEAKLR 605
Query: 294 PSTWSLL 300
PS LL
Sbjct: 606 PSADELL 612
>CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 615
Score = 89.4 bits (220), Expect = 9e-18
Identities = 81/302 (26%), Positives = 137/302 (44%), Gaps = 50/302 (16%)
Query: 4 NERQPTYRLLEEIGRGSFG---SVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAI 60
++ Q Y +G G F RK+ + ++++ V+ + + + R++L E I
Sbjct: 29 DDMQVPYEKGAFLGEGGFAHCFEFRKL--DCNDRLAVKVVPKVILLKSTAREKLTREVEI 86
Query: 61 LSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV 120
QL H NIV+F H+ D S ++ +E CSK L ++ + QR + E +
Sbjct: 87 HRQLSHRNIVQFHHFFED--SQNVYFTLELCSKNSLMELNK----QRGPLTEHEARFYTI 140
Query: 121 QILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNAS 180
Q+ + + L LQ +IHRDLK GN+FL +
Sbjct: 141 QVAEGV------KHLHNLQ----------------IIHRDLKLGNLFLNEH--------- 169
Query: 181 DVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCIL 240
+ +K+GDFGLA + + E T GTP Y++PEVL + ++ DIW++GCIL
Sbjct: 170 ------LQVKIGDFGLATFCEKN-EKKMTRGGTPNYIAPEVLNETGHAFEVDIWAIGCIL 222
Query: 241 YELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
Y L PF+++ E ++K + +P S +I + +RP+ ++L
Sbjct: 223 YVLLFGSPPFESRRVQETYVRIKNNDY-VVPENASPTANRLIRSLLDPVPDRRPTAEAVL 281
Query: 301 ND 302
D
Sbjct: 282 LD 283
>SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 460
Score = 89.0 bits (219), Expect = 1e-17
Identities = 80/303 (26%), Positives = 132/303 (43%), Gaps = 63/303 (20%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNK-----VMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y ++ +G G+F V+ V K ++ ++++ + + E IL L
Sbjct: 167 YEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSSEKRATEMFQREIDILKSL 226
Query: 65 KHDNIV---EFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
H +V E F D + LF+ MEY GDL + + E+ ++ Q
Sbjct: 227 HHPGVVQCHEIFENDDE-----LFIVMEYVEGGDLMDFLI----ANGSIDEQDCKPLLKQ 277
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
+L L H +G V HRD+KP NI +T ++F+
Sbjct: 278 LLETLLHLH--------------------KQG--VTHRDIKPENILIT---NDFH----- 307
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR------DQPYSPLSDIWS 235
+K+ DFGLAK + + F T+ GT Y++PEVL+ D Y DIWS
Sbjct: 308 -------LKISDFGLAKVIHGTGTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWS 360
Query: 236 LGCILYELCSLHVPFQAKTYTELQGKVKAGYF--EP-LPHFYSKNLQDIITRCIQVDFTK 292
LGC+LY + + +PF + + + + G + EP L + S+ D+I R ++++ K
Sbjct: 361 LGCVLYVMLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEK 420
Query: 293 RPS 295
R S
Sbjct: 421 RIS 423
>Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 890
Score = 89.0 bits (219), Expect = 1e-17
Identities = 92/332 (27%), Positives = 137/332 (40%), Gaps = 51/332 (15%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFF 73
E +G G FG V + + K + K+ QL +E AIL L H IV
Sbjct: 580 EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLE 639
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
+ +F+ ME GD+ +MI ++ +PE ++ QIL+AL H+
Sbjct: 640 CMFETPER--VFVVMEKLH-GDMLEMI--LSSEKSRLPERITKFMVTQILVALRNLHFKN 694
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
++H DLKP N+ L + F Q +KL D
Sbjct: 695 ----------------------IVHCDLKPENVLLASAEP-FPQ-----------VKLCD 720
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG A+ + F + VGTP Y++PEVLR + Y+ D+WS+G I+Y S PF
Sbjct: 721 FGFARIIGEK-SFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNED 779
Query: 254 TYTELQGKVKAGYFEPLP-HFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRICRKAL 312
Q + A + P P S D+I +QV KR S L+ + + L
Sbjct: 780 EDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWL 839
Query: 313 DLEKFERHLLNYEHELTQVGEMLEQHATEMKR 344
DL +FE T++GE H ++ R
Sbjct: 840 DLREFE----------TRIGERYITHESDDAR 861
>CE18009 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 384
Score = 89.0 bits (219), Expect = 1e-17
Identities = 73/248 (29%), Positives = 102/248 (40%), Gaps = 53/248 (21%)
Query: 13 LEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEF 72
L IG G++G V K + DN K +R + E + + L+HDNIV
Sbjct: 48 LRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTL 107
Query: 73 F---HWDHDAKSNTLF---------LYM--EYCSKGDLSQMIRYYKHQRKYVPEEYVWRI 118
F + H N +F LYM E+ + DL ++ + +P YV
Sbjct: 108 FDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDR-DLKNLLEMLEPTNSVLPPNYVKSF 166
Query: 119 MVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQN 178
M Q+L AL CH R ++HRDLKP NI ++
Sbjct: 167 MWQLLSALSYCHLRR----------------------IVHRDLKPQNILVS--------- 195
Query: 179 ASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-DQPYSPLSDIWSLG 237
+IK+ DFGLA++ T V T +Y PE+L Q YS D+WSLG
Sbjct: 196 ------DSGVIKIADFGLARNFSFPSRNYTHEVVTLWYRPPEILLGSQRYSTSLDMWSLG 249
Query: 238 CILYELCS 245
CI E+ S
Sbjct: 250 CIFSEIAS 257
>At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 736
Score = 89.0 bits (219), Expect = 1e-17
Identities = 77/296 (26%), Positives = 134/296 (45%), Gaps = 47/296 (15%)
Query: 11 RLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIV 70
+L EE+GRGSF +V + V + + K G NA + E I+ +L+H N++
Sbjct: 469 QLGEEVGRGSFAAVHRGVWNGSDVAI--KVYFDGDYNAMTLTECKKEINIMKKLRHPNVL 526
Query: 71 EFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCH 130
F + + + MEY +G L +++ + + + ++ R+ + + + H
Sbjct: 527 LFMGAVCTEEKSAII--MEYMPRGSLFKILH---NTNQPLDKKRRLRMALDVARGMNYLH 581
Query: 131 YGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIK 190
+ ++HRDLK N+ + D +N +K
Sbjct: 582 --------------------RRNPPIVHRDLKSSNLLV---DKNWN------------VK 606
Query: 191 LGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPF 250
+GDFGL+K A+ + GTP +M+PEVLR +P + D++S G IL+EL + VP+
Sbjct: 607 VGDFGLSKWKNATFLSTKSGKGTPQWMAPEVLRSEPSNEKCDVFSFGVILWELMTTLVPW 666
Query: 251 QAKTYTELQGKVKAGYFE---PLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDI 303
++ G V G+ + LP + + II C Q D KRPS L++ +
Sbjct: 667 DRLNSIQVVGVV--GFMDRRLDLPEGLNPRIASIIQDCWQTDPAKRPSFEELISQM 720
>At2g45490 [D] KOG0580 Serine/threonine protein kinase
Length = 288
Score = 89.0 bits (219), Expect = 1e-17
Identities = 79/283 (27%), Positives = 133/283 (46%), Gaps = 50/283 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER--QQLISECAILSQLKHDNIVEFF 73
+G+G FG V + REA +K +V +V + K + QL E I + L+H NI+ F
Sbjct: 28 LGKGKFGRVY-LAREAKSKYIVALKVIFKEQIEKYKIHHQLRREMEIQTSLRHPNILRLF 86
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
W HD + +FL +EY G+L +++ Q ++ E+ + + AL CH
Sbjct: 87 GWFHD--NERIFLILEYAHGGELYGVLK----QNGHLTEQQAATYIASLSQALAYCH--- 137
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
G VIHRD+KP N+ L D E +K+ D
Sbjct: 138 -------------------GKCVIHRDIKPENLLL---DHEGR------------LKIAD 163
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG S+Q+S + T GT Y++PE++ ++ + D W+LG + YE + PF+A+
Sbjct: 164 FGW--SVQSSNK-RKTMCGTLDYLAPEMVENRDHDYAVDNWTLGILCYEFLYGNPPFEAE 220
Query: 254 TYTELQGKV-KAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
+ + ++ K PL S+ +++I++ + D +KR S
Sbjct: 221 SQKDTFKRILKIDLSFPLTPNVSEEAKNLISQLLVKDPSKRLS 263
>At1g49160 [R] KOG0584 Serine/threonine protein kinase
Length = 557
Score = 89.0 bits (219), Expect = 1e-17
Identities = 77/267 (28%), Positives = 126/267 (46%), Gaps = 47/267 (17%)
Query: 5 ERQPTYRLL---EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER--QQLISECA 59
E PT R + E IG+G+ +V K E D + +VR + ++L SE
Sbjct: 20 EIDPTCRYIRYKEVIGKGASKTVFKGFDEVDGIEVAWNQVRIDDLLQSPDCLERLYSEVR 79
Query: 60 ILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIM 119
+L LKH NI+ F++ D K+ T+ + E + G L Q Y K RK
Sbjct: 80 LLKSLKHKNIIRFYNSWIDDKNKTVNIITELFTSGSLRQ---YRKKHRK----------- 125
Query: 120 VQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNA 179
+ M KC + L+ L+ ++ S+ +IHRD+K NIF+ G E
Sbjct: 126 --VNMKAVKCWARQILTGLKYLH--------SQDPPIIHRDIKCDNIFINGNHGE----- 170
Query: 180 SDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCI 239
+K+GD GLA ++ + A + +GTP +M+PE L D+ Y+ L+DI+S G
Sbjct: 171 ---------VKIGDLGLATVMEQA--NAKSVIGTPEFMAPE-LYDENYNELADIYSFGMC 218
Query: 240 LYELCSLHVPF-QAKTYTELQGKVKAG 265
+ E+ + P+ + + ++ KV +G
Sbjct: 219 MLEMVTFEYPYCECRNSAQIYKKVSSG 245
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 89.0 bits (219), Expect = 1e-17
Identities = 80/303 (26%), Positives = 132/303 (43%), Gaps = 51/303 (16%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLK-HD 67
T+ + E IG+G++G V KV+ + + + K + H +E + +E IL L H
Sbjct: 20 TWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIE---AEYNILKALSDHP 76
Query: 68 NIVEFF--HWDHD-AKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
N+V F+ ++ D + L+L +E CS G ++ +++ + + + + E + I+ + LM
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
L H + IHRD+K NI LT
Sbjct: 137 GLQHLHNNK----------------------TIHRDVKGNNILLT--------------- 159
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-----DQPYSPLSDIWSLGCI 239
++ +KL DFG++ L ++ T VGTP++M+PEV+ D Y D WSLG
Sbjct: 160 TEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGIT 219
Query: 240 LYELCSLHVPFQAKTYTELQGKVKAGYFEPL--PHFYSKNLQDIITRCIQVDFTKRPSTW 297
EL P K+ L P +S D I++C+ D+ KRP+
Sbjct: 220 AIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVS 279
Query: 298 SLL 300
LL
Sbjct: 280 ELL 282
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 89.0 bits (219), Expect = 1e-17
Identities = 80/303 (26%), Positives = 132/303 (43%), Gaps = 51/303 (16%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLK-HD 67
T+ + E IG+G++G V KV+ + + + K + H +E + +E IL L H
Sbjct: 20 TWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIE---AEYNILKALSDHP 76
Query: 68 NIVEFF--HWDHD-AKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
N+V F+ ++ D + L+L +E CS G ++ +++ + + + + E + I+ + LM
Sbjct: 77 NVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALM 136
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
L H + IHRD+K NI LT
Sbjct: 137 GLQHLHNNK----------------------TIHRDVKGNNILLT--------------- 159
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-----DQPYSPLSDIWSLGCI 239
++ +KL DFG++ L ++ T VGTP++M+PEV+ D Y D WSLG
Sbjct: 160 TEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGIT 219
Query: 240 LYELCSLHVPFQAKTYTELQGKVKAGYFEPL--PHFYSKNLQDIITRCIQVDFTKRPSTW 297
EL P K+ L P +S D I++C+ D+ KRP+
Sbjct: 220 AIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVS 279
Query: 298 SLL 300
LL
Sbjct: 280 ELL 282
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 88.6 bits (218), Expect = 1e-17
Identities = 69/249 (27%), Positives = 117/249 (46%), Gaps = 49/249 (19%)
Query: 1 MNRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAI 60
M N Y LE +GRGS+G+V + + + + K + + E + E A+
Sbjct: 1 MENNTASSPYTKLELVGRGSYGAVYRGICNLTKETVAIKILNLD-TDEDEVSDIQKEVAV 59
Query: 61 LSQLKH---DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWR 117
LS+LK +NI+++ H + +N L++ M+YC G + ++ + + E +
Sbjct: 60 LSELKQSDVENIIKY-HGSYLVGTN-LWIIMDYCHGGSVRTLM-----EAGPISEPCISL 112
Query: 118 IMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQ 177
I+ + L AL H+ +IHRD+K NI ++ +
Sbjct: 113 ILRETLQALKFIHHAG----------------------IIHRDIKAANILVSMSGN---- 146
Query: 178 NASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRD-QPYSPLSDIWSL 236
+KL DFG+A L + T++GTPY+M+PEV+RD Q Y+ ++DIWSL
Sbjct: 147 -----------VKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSL 195
Query: 237 GCILYELCS 245
G YE+ +
Sbjct: 196 GITAYEIAT 204
>CE28251 [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 469
Score = 88.6 bits (218), Expect = 1e-17
Identities = 84/310 (27%), Positives = 143/310 (46%), Gaps = 55/310 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEV------RYGHMNAKERQQLISECAILSQLKHDNI 69
+G+G FG V +++D V+ K++ R AK R + +E ++ +L H NI
Sbjct: 175 LGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRD-IQNEVEVMKKLSHPNI 233
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + AK + ++ +EY G+ + K+ + + E Q++ A+
Sbjct: 234 VAIYDCITVAKYS--YMVIEYVGGGEFFSKLVDSKYNQMGLGESLGKYFAFQLIDAVLYL 291
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H S G + HRD+KP NI + + + I+
Sbjct: 292 H--------------------SVG--ICHRDIKPENILCSNKAE------------RCIL 317
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQ--PYSPLSDIWSLGCILYELCSLH 247
KL DFG+AK+ S+ T+ GTP Y +PE++ +Q Y+P DIWSLGC+L+ S +
Sbjct: 318 KLTDFGMAKN---SVNRMKTHCGTPSYCAPEIVANQGVEYTPKVDIWSLGCVLFITFSGY 374
Query: 248 VPFQAKTYTELQ--GKVKAG--YFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND- 302
PF ++ YT+L+ +V G +F H + Q++I + V+ RPS L++
Sbjct: 375 PPF-SEEYTDLKMDEQVLTGRLFFHEQWHRITDETQNMIQWMLTVEPLIRPSAVELMSTQ 433
Query: 303 -IQCRICRKA 311
++C C A
Sbjct: 434 WMKCADCLSA 443
>7302861 [T] KOG0696 Serine/threonine protein kinase
Length = 700
Score = 88.6 bits (218), Expect = 1e-17
Identities = 81/291 (27%), Positives = 123/291 (41%), Gaps = 48/291 (16%)
Query: 6 RQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQL-ISECAILSQL 64
R + ++ IG+GSFG V R +++ K +R + + +L ++E IL+
Sbjct: 367 RAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILALS 426
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+ H LF MEYC GDL ++ Y ++ V Y V++ +
Sbjct: 427 GRPPFLVSMHSCFQTMDR-LFFVMEYCKGGDLMYHMQQYGRFKESVAIFYA----VEVAI 481
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
ALF H RD +I+RDLK NI L G
Sbjct: 482 ALFFLHE-RD---------------------IIYRDLKLDNILLDGEGH----------- 508
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELC 244
+KL DFGL+K + T+ GTP YM+PE++ PYS +D WS G +L+E
Sbjct: 509 ----VKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFM 564
Query: 245 SLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
+ PF+ T + +K P +S DIIT + TK+P+
Sbjct: 565 AGQAPFEGDDETTVFRNIK-DKKAVFPKHFSVEAMDIITSFL----TKKPN 610
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 88.6 bits (218), Expect = 1e-17
Identities = 73/298 (24%), Positives = 127/298 (42%), Gaps = 52/298 (17%)
Query: 7 QPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ + ++ ++G GS+GSV K V + + ++ K V + ++I E +I+ Q
Sbjct: 39 EKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPV----ESDLHEIIKEISIMQQCDS 94
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V ++ K L++ MEYC G +S ++R K K + E+ + I+ L L
Sbjct: 95 PYVVRYY--GSYFKQYDLWICMEYCGAGSVSDIMRLRK---KTLTEDEIATILSDTLQGL 149
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
H R IHRD+K NI L ++
Sbjct: 150 VYLHLRRK----------------------IHRDIKAANILLN---------------TE 172
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
KL DFG+A L ++ T +GTP++M+PEV+ + Y ++DIWSLG E+
Sbjct: 173 GYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEG 232
Query: 247 HVPF----QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
P+ + + K + E P +S D +++C+ + R + LL
Sbjct: 233 KPPYGEIHPMRAIFMIPQKPPPSFRE--PDRWSTEFIDFVSKCLVKEPDDRATATELL 288
>SPCC1322.08 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 580
Score = 88.2 bits (217), Expect = 2e-17
Identities = 78/312 (25%), Positives = 134/312 (42%), Gaps = 62/312 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQ----------QLISECA 59
Y LL+++G G+F +V K + + + K V+ N R ++ E
Sbjct: 124 YTLLQKMGDGAFSNVYKAIHNRTGEKVAIKVVQRAQPNTDPRDPRKRQGVESHNILKEVQ 183
Query: 60 ILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDL-SQMIRYYKHQRKYVPEEYVWRI 118
I+ ++KH NI++ + + +L +E G+L Q++R Y E+ +
Sbjct: 184 IMRRVKHPNIIQLLEFIQTPEY--YYLVLELADGGELFHQIVRL-----TYFSEDLSRHV 236
Query: 119 MVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDD----- 173
+ Q+ A+ H + V+HRD+KP N+ D
Sbjct: 237 ITQVAHAIRYLH---------------------EDCGVVHRDIKPENLLFDSIDFVPSRV 275
Query: 174 ---EFNQNASDVDYSKVI----------IKLGDFGLAKSLQASIEFATTYVGTPYYMSPE 220
+ VD + I I+L DFGL+K + S T GT Y +PE
Sbjct: 276 RKYRAGDDPDKVDEGEFIPGVGAGTIGRIRLADFGLSKVVWDS--HTQTPCGTMGYTAPE 333
Query: 221 VLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFY---SKN 277
++RD+ YS D+W+LGC+LY + PF ++ + L KV G + L ++ SK+
Sbjct: 334 IVRDERYSKGVDMWALGCVLYTILCGFPPFYDESISLLTKKVSRGEYSFLSPWWDDISKS 393
Query: 278 LQDIITRCIQVD 289
+D+I+ + VD
Sbjct: 394 AKDLISHLLTVD 405
>CE21025 [D] KOG0580 Serine/threonine protein kinase
Length = 326
Score = 88.2 bits (217), Expect = 2e-17
Identities = 73/250 (29%), Positives = 119/250 (47%), Gaps = 46/250 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGH--MNAKERQQLISECAILSQLKHDNIVEFF 73
+G+G FG+V + RE K ++ +V + + QL E I L+H NI+ +
Sbjct: 50 LGKGKFGNVF-ISREKKTKRIIALKVLFKTQLLQLGVSHQLKREIEIQYHLRHPNILTLY 108
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
+ HD K +F+ ++Y S+G+L +++ + V E R + Q+ AL CH
Sbjct: 109 GYFHDDKR--VFVILDYASRGELFNVLQSQPGHK--VNEVIAGRFVRQLANALHYCH--- 161
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
SKG VIHRD+KP N+ L SK+ +KL D
Sbjct: 162 -----------------SKG--VIHRDIKPENLLLD---------------SKLNLKLAD 187
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG S+ A T GT Y++PE++ +QP+ DIW++G +L+E+ + PF +
Sbjct: 188 FGW--SVVADHSKRHTLCGTMDYLAPEMVSNQPHDFNVDIWAIGILLFEMLVGYAPFANQ 245
Query: 254 TYTELQGKVK 263
T +L ++K
Sbjct: 246 TGDKLIARIK 255
>CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 357
Score = 88.2 bits (217), Expect = 2e-17
Identities = 85/308 (27%), Positives = 123/308 (39%), Gaps = 70/308 (22%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEV-----------------RYGHMNA---- 48
YRL+EEIG+GS+G V+ E D + K + R NA
Sbjct: 21 YRLMEEIGQGSYGIVKLAYNEEDKNLYALKVLDKMKLLKNFACFRQPPPRRNKENAAPSV 80
Query: 49 -KERQQLI-SECAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQ 106
+ QL+ E AIL +L H N+V+ D N L++ E+ KG + ++
Sbjct: 81 LRNPLQLVQKEIAILKKLSHPNVVKLVEVLDDPNDNYLYMVFEFVEKGSILEI-----PT 135
Query: 107 RKYVPEEYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNI 166
K + E+ W L L HY + ++HRD+KP N+
Sbjct: 136 DKPLDEDTAWSYFRDTLCGLEYLHYQK----------------------IVHRDIKPSNL 173
Query: 167 FLTGYDDEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQP 226
L SD+ +K+ DFG++ + F + GTP +M+PE L +
Sbjct: 174 LL-----------SDIGQ----VKIADFGVSCEFEGIDAFLSGTAGTPAFMAPEALTEGA 218
Query: 227 ---YS-PLSDIWSLGCILYELCSLHVPFQAKTYTELQGKVKAG-YFEPLPHFYSKNLQDI 281
YS DIWSLG LY VPF L K+K P S+ LQDI
Sbjct: 219 NHFYSGRAQDIWSLGITLYAFVIGTVPFVDNYIIALHKKIKNDPIVFPEAPILSEALQDI 278
Query: 282 ITRCIQVD 289
I ++ D
Sbjct: 279 ILGMLKKD 286
>At2g25090 [T] KOG0583 Serine/threonine protein kinase
Length = 469
Score = 88.2 bits (217), Expect = 2e-17
Identities = 78/298 (26%), Positives = 134/298 (44%), Gaps = 56/298 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKE--RQQLISECAILSQLKHD 67
Y + +G G+F V + + K ++ H+ + +Q+ E A++ L+H
Sbjct: 15 YNIGRLLGTGNFAKVYHGTEISTGDDVAIKVIKKDHVFKRRGMMEQIEREIAVMRLLRHP 74
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
N+VE + A +F MEY + G+L +MI + +PE+ + Q++ A+
Sbjct: 75 NVVELR--EVMATKKKIFFVMEYVNGGELFEMI----DRDGKLPEDLARKYFQQLISAVD 128
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH S+G V HRD+KP N+ L G D
Sbjct: 129 FCH--------------------SRG--VFHRDIKPENLLLDGEGD-------------- 152
Query: 188 IIKLGDFGLAKSLQ---------ASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLG 237
+K+ DFGL+ + +S + T GTP Y++PEVLR++ Y ++DIWS G
Sbjct: 153 -LKVTDFGLSALMMPEGLGGRRGSSDDLLHTRCGTPAYVAPEVLRNKGYDGAMADIWSCG 211
Query: 238 CILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
+LY L + +PF + L K+ E P ++S +++++R + D +R S
Sbjct: 212 IVLYALLAGFLPFIDENVMTLYTKIFKAECE-FPPWFSLESKELLSRLLVPDPEQRIS 268
>7299793 [T] KOG0583 Serine/threonine protein kinase
Length = 540
Score = 88.2 bits (217), Expect = 2e-17
Identities = 79/304 (25%), Positives = 137/304 (44%), Gaps = 54/304 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y + + +G GS+G V++ + + K++ ++++R Q + E A+L QL
Sbjct: 145 YIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLR---RIPNGEQNVTREIALLKQL 201
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
KH ++VE ++ + ++L MEYC G L +MI Y +R M
Sbjct: 202 KHRHVVELVDVLYNEEKQKMYLVMEYC-VGGLQEMIDYQPDKR----------------M 244
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
LF+ H + + D +E + VIH+D+KPGN+ L+ +D
Sbjct: 245 PLFQAH-----GYFKQLVDGLEYLHSCR---VIHKDIKPGNLLLS------------LDQ 284
Query: 185 SKVIIKLGDFGLAKSLQ--ASIEFATTYVGTPYYMSPEVLR-DQPYSPLS-DIWSLGCIL 240
+ +K+ DFG+A+ L A + TT G+P + PE+ + ++ DIWS G L
Sbjct: 285 T---LKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIWSSGVTL 341
Query: 241 YELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFY--SKNLQDIITRCIQVDFTKRPSTWS 298
Y L + PF+ L + G +E Y + ++I +Q D +KR S
Sbjct: 342 YNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQE 401
Query: 299 LLND 302
+ +D
Sbjct: 402 IRHD 405
>7297776 [D] KOG0580 Serine/threonine protein kinase
Length = 329
Score = 88.2 bits (217), Expect = 2e-17
Identities = 84/312 (26%), Positives = 133/312 (41%), Gaps = 57/312 (18%)
Query: 16 IGRGSFGSVRKVVREADN------KVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+GRG FG V + RE + KVM ++E+R G + ++Q++ E I S+LKH +I
Sbjct: 59 LGRGKFGRVY-LARERHSHYLVAMKVMFKEELRKGCV----QRQVLREIEIQSRLKHPHI 113
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ W HD + ++L +E S+G+L + +R + R P + Q+ AL C
Sbjct: 114 LRLLTWFHD--ESRIYLALEIASEGELFKHLRGAPNHRFDEPRSA--KYTYQVANALNYC 169
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H VIHRDLKP NI LT DD +
Sbjct: 170 HLNN----------------------VIHRDLKPENILLTSTDD---------------L 192
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFG S T GT Y+ PE++ Y D W LG + YE P
Sbjct: 193 KLADFGW--SAHTPNNKRRTLCGTLDYLPPEMVDGNSYDDSVDQWCLGILCYEFVVGCPP 250
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND--IQCRI 307
F++ + K++ P SK +++I ++ + R + ++ ++ +
Sbjct: 251 FESNSTESTYSKIRRMEIS-YPSHLSKGCKELIGGLLRKESKGRITLVDVMTHYWVKAGM 309
Query: 308 CRKALDLEKFER 319
+ L L+K ER
Sbjct: 310 AERELQLQKRER 321
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 87.8 bits (216), Expect = 3e-17
Identities = 82/295 (27%), Positives = 122/295 (40%), Gaps = 48/295 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L +IG+G+ G V N + K++ KE +I+E ++ KH NI
Sbjct: 620 YANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKEL--IINEILVMKGSKHPNI 677
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V F D L++ MEY G L+ ++ + + E + + + L L
Sbjct: 678 VNFI--DSYVLKGDLWVIMEYMEGGSLTDVVTHC-----ILTEGQIGAVCRETLSGL--- 727
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
E L SKG V+HRD+K NI L+ D I
Sbjct: 728 -----------------EFLHSKG--VLHRDIKSDNILLSMEGD---------------I 753
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
KL DFG + TT VGTPY+M+PEV+ + Y P DIWSLG ++ E+ P
Sbjct: 754 KLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPP 813
Query: 250 FQAKTYTELQGKVKAGYFEPL--PHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
+ +T + L P S +L+ + C+ V+ R S LL+D
Sbjct: 814 YLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHD 868
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 87.8 bits (216), Expect = 3e-17
Identities = 84/306 (27%), Positives = 133/306 (43%), Gaps = 56/306 (18%)
Query: 2 NRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRY-GHMNAKERQQLISECAI 60
N+++ + + L EIG GSFG+V +++ K++ Y G + ++ Q ++ E
Sbjct: 19 NKHDPEKIFEDLREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRF 78
Query: 61 LSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV 120
L QL H N +E+ + +T +L MEYC G S +I +K K + E+ + I +
Sbjct: 79 LRQLNHPNTIEY--KGCYLRESTAWLVMEYC-VGSASDIIEVHK---KPLHEDEIAAICL 132
Query: 121 QILMALFKCH-YGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNA 179
+L L H GR IHRD+K GNI LT
Sbjct: 133 GVLSGLSYLHSLGR-----------------------IHRDIKAGNILLT---------- 159
Query: 180 SDVDYSKVIIKLGDFGLAKSLQASIEF-ATTYVGTPYYMSPEV---LRDQPYSPLSDIWS 235
++KL DFG A+I+ A ++VGTPY+M+PEV + + Y D+WS
Sbjct: 160 -----DNGVVKLADFG-----SAAIKCPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWS 209
Query: 236 LGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLP-HFYSKNLQDIITRCIQVDFTKRP 294
LG EL P+ + LP + +S + C++ +RP
Sbjct: 210 LGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPKNDWSDAFCSFVELCLKKMPAERP 269
Query: 295 STWSLL 300
S+ LL
Sbjct: 270 SSAKLL 275
>YFR014c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 446
Score = 87.4 bits (215), Expect = 3e-17
Identities = 81/301 (26%), Positives = 130/301 (42%), Gaps = 61/301 (20%)
Query: 16 IGRGSFGSVRKVVREADN---------KVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+G G+FG VVR+A N K++++K ++ N + + L E IL +L H
Sbjct: 43 LGAGTFG----VVRQAKNTETGEDVAVKILIKKALKG---NKVQLEALYDELDILQRLHH 95
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
NIV F W +S F + +KG ++ + K+ E+ V RI+V+IL A+
Sbjct: 96 PNIVAFKDW---FESKDKFYIITQLAKG--GELFDRILKKGKFTEEDAV-RILVEILSAV 149
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
H ++HRDLKP N+ DE S
Sbjct: 150 KYMHSQN----------------------IVHRDLKPENLLYIDKSDE----------SP 177
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
+++ DFG+AK L++ E G+ Y++PEVL + DIWS+G I Y L
Sbjct: 178 LVV--ADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCG 235
Query: 247 HVPFQAKTYTEL-----QGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
+ F+A+ + G+ + P S + I + + +D +KRP+ LL
Sbjct: 236 YSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELLE 295
Query: 302 D 302
D
Sbjct: 296 D 296
>Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 87.4 bits (215), Expect = 3e-17
Identities = 84/322 (26%), Positives = 141/322 (43%), Gaps = 56/322 (17%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER----QQLISECAILSQLKHDNI 69
EE+G G F V+K ++ K ++ + R + + E +IL +++H N+
Sbjct: 17 EELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNV 76
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ H ++ K++ + L +E + G+L + +++ + EE + QIL ++
Sbjct: 77 ITL-HEVYENKTDVI-LILELVAGGELFDFLA----EKESLTEEEATEFLKQILNGVYYL 130
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H LQ + H DLKP NI L D + K I
Sbjct: 131 H------SLQ----------------IAHFDLKPENIMLL-----------DRNVPKPRI 157
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
K+ DFGLA + EF + GTP +++PE++ +P +D+WS+G I Y L S P
Sbjct: 158 KIIDFGLAHKIDFGNEFKNIF-GTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP 216
Query: 250 FQAKTYTELQGKVKAGYFEPLPHFYSKN---LQDIITRCIQVDFTKRPS-------TWSL 299
F T E V A +E ++S +D I R + D KR + W
Sbjct: 217 FLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276
Query: 300 LNDIQCRICRK--ALDLEKFER 319
D Q + RK A+++EKF++
Sbjct: 277 PKDTQQALSRKASAVNMEKFKK 298
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 87.0 bits (214), Expect = 4e-17
Identities = 85/293 (29%), Positives = 124/293 (42%), Gaps = 52/293 (17%)
Query: 13 LEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER-QQLISECAILSQLKHDNIVE 71
L EIG GSFG+V N+V+ K++ Y E+ Q ++ E L QLKH N +E
Sbjct: 27 LHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIE 86
Query: 72 FFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHY 131
+ K +T +L MEYC G S ++ +K K + E + I L L H
Sbjct: 87 YKGCY--LKEHTAWLVMEYCL-GSASDLLEVHK---KPLQEVEIAAITHGALHGLAYLH- 139
Query: 132 GRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKL 191
+ +IHRD+K GNI LT E Q +KL
Sbjct: 140 ---------------------SHALIHRDIKAGNILLT----EPGQ-----------VKL 163
Query: 192 GDFGLAKSLQASIEFATTYVGTPYYMSPEV---LRDQPYSPLSDIWSLGCILYELCSLHV 248
DFG A A ++VGTPY+M+PEV + + Y DIWSLG EL
Sbjct: 164 ADFGSASMASP----ANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKP 219
Query: 249 P-FQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
P F + L + + ++ + + + C+Q +RP++ LL
Sbjct: 220 PLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELL 272
>CE21213 [UT] KOG0662 Cyclin-dependent kinase CDK5
Length = 292
Score = 87.0 bits (214), Expect = 4e-17
Identities = 65/241 (26%), Positives = 106/241 (43%), Gaps = 44/241 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y +E+IG G++G+V K + +++ K VR + + E IL +LKH N+
Sbjct: 4 YDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILRELKHRNV 63
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V + H N L L EYC + + +++ Y+ + +M+Q+L L C
Sbjct: 64 VRLYDVVH--SENKLTLVFEYCDQ----DLKKFFDSLNGYMDAQTARSLMLQLLRGLSFC 117
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + V+HRDLKP N+ + N N + +
Sbjct: 118 H----------------------AHHVLHRDLKPQNLLI-------NTNGT--------L 140
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL-RDQPYSPLSDIWSLGCILYELCSLHV 248
KL DFGLA++ + + V T +Y P+VL + Y+ D+WS GCI E+ +
Sbjct: 141 KLADFGLARAFGVPVRCFSAEVVTLWYRPPDVLFGAKLYNTSIDMWSAGCIFAEISNAGR 200
Query: 249 P 249
P
Sbjct: 201 P 201
>CE09360 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 2783
Score = 87.0 bits (214), Expect = 4e-17
Identities = 80/302 (26%), Positives = 134/302 (43%), Gaps = 50/302 (16%)
Query: 4 NERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQ 63
N+ Q Y + EE+G+G++G+V + +A K K V+ +++ +I E ++++Q
Sbjct: 189 NDLQAKYIIHEELGKGAYGTVYRATEKATGKTWAAKMVQV--RPGVKKENVIHEISMMNQ 246
Query: 64 LKHDNIVEFFHWDHDA--KSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
L H+ ++ H+A N ++L E+ S G+L + I + EE V M Q
Sbjct: 247 LHHEKLLNL----HEAFDMGNEMWLIEEFVSGGELFEKIL---EDDSLMSEEEVRDYMHQ 299
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
IL+ + H + ++H DLKP NI L +N+++
Sbjct: 300 ILLGVSHMHKNQ----------------------IVHLDLKPENILLKA------KNSNE 331
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILY 241
+K+ DFGLA+ L + GTP + +PEV+ QP +D+W++G I Y
Sbjct: 332 -------LKIIDFGLARKLDPKKSVKLLF-GTPEFCAPEVVNYQPVGLSTDMWTVGVISY 383
Query: 242 ELCSLHVPFQAKTYTELQGKVKAG---YFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWS 298
L S PF + + V A + +P S +D I R + D KR S
Sbjct: 384 VLLSGLSPFLGDSDEDTLANVSASDWDFDDPSWDDVSDLAKDFICRLMIKDKRKRMSVQD 443
Query: 299 LL 300
L
Sbjct: 444 AL 445
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 86.7 bits (213), Expect = 6e-17
Identities = 82/301 (27%), Positives = 135/301 (44%), Gaps = 56/301 (18%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER------QQLISECAILSQLKHD 67
E IG+GSFG+V + ++M K+V +++ + L SE + L L H
Sbjct: 1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHL 1238
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
NIV++ +++ K+N L++EY + G + +IR Y E + + Q+L L
Sbjct: 1239 NIVQYLGFEN--KNNIYSLFLEYVAGGSVGSLIRMYGR----FDEPLIKHLTTQVLKGLA 1292
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
H SKG ++HRD+K N+ L D D
Sbjct: 1293 YLH--------------------SKG--ILHRDMKADNLLL------------DQDG--- 1315
Query: 188 IIKLGDFGLA-KSLQASIEFATTYVGTPYYMSPEVL-RDQPYSPLSDIWSLGCILYELCS 245
I K+ DFG++ KS T GT ++M+PE++ Q YS DIWSLGCI+ E+ +
Sbjct: 1316 ICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA 1375
Query: 246 LHVPFQAKTYTELQGKV-KAGYFEPLPH----FYSKNLQDIITRCIQVDFTKRPSTWSLL 300
P+ K+ K+ P+P S+ ++ + C +++ KRP+ LL
Sbjct: 1376 GKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELL 1435
Query: 301 N 301
+
Sbjct: 1436 S 1436
>YDR477w [T] KOG0583 Serine/threonine protein kinase
Length = 633
Score = 86.7 bits (213), Expect = 6e-17
Identities = 73/295 (24%), Positives = 127/295 (42%), Gaps = 48/295 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLIS-ECAILSQLKHDN 68
Y++++ +G GSFG V+ + + K + + + Q I E + L L+H +
Sbjct: 55 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPH 114
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I++ + D + + + +EY ++ QR + E+ R QI+ A+
Sbjct: 115 IIKLY--DVIKSKDEIIMVIEYAGNELFDYIV-----QRDKMSEQEARRFFQQIISAVEY 167
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH + ++HRDLKP N+ L D+ N
Sbjct: 168 CHRHK----------------------IVHRDLKPENLLL---DEHLN------------ 190
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLH 247
+K+ DFGL+ ++ F T G+P Y +PEV+ + Y+ P D+WS G ILY +
Sbjct: 191 VKIADFGLS-NIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRR 249
Query: 248 VPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
+PF ++ L + G + LP F S +I R + V+ R S ++ D
Sbjct: 250 LPFDDESIPVLFKNISNGVY-TLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQD 303
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 86.7 bits (213), Expect = 6e-17
Identities = 72/287 (25%), Positives = 115/287 (39%), Gaps = 45/287 (15%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFF 73
E IG+GSFG V K + +V+ K + E + E +LSQ + +++
Sbjct: 17 ERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAE-DEIDDIQQEIMVLSQCDSPYVTKYY 75
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
K L++ MEY G +++ + E ++ I+ ++L L H R
Sbjct: 76 --GSFLKGTKLWIIMEYLGGGSALDLMKAGSFE-----EMHIGIILREVLKGLDYLHSER 128
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
L HRD+K N+ L+ D +KL D
Sbjct: 129 KL----------------------HRDIKAANVLLSEQGD---------------VKLAD 151
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG+A L + T+VGTP++M+PEV++ Y +DIWSLG EL P
Sbjct: 152 FGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSEL 211
Query: 254 TYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ + L Y+K+ +D + C+ D RP+ LL
Sbjct: 212 HPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELL 258
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 86.7 bits (213), Expect = 6e-17
Identities = 74/302 (24%), Positives = 130/302 (42%), Gaps = 47/302 (15%)
Query: 2 NRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAIL 61
N ++ + Y+ +E+G+G+ G V + + N+ V + N + +++E +L
Sbjct: 285 NSDDPRERYKTTQEVGKGASGIVF-IAADLQNESQVAVKT-IDMKNQSSKDLILTEIRVL 342
Query: 62 SQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
H N+V F + L++ MEY G L+ ++ + E + + +
Sbjct: 343 KDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVT-----ETVMKERQIACVCRE 397
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
L A+ H +KG +IHRD+K N+ L G D
Sbjct: 398 TLYAISFLH--------------------AKG--IIHRDIKSDNVLL-GMDGS------- 427
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILY 241
+K+ DFG +++ E T VGTPY+M+PEV+ + Y DIWS+G +
Sbjct: 428 -------VKVTDFGFCANIEGD-EKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAI 479
Query: 242 ELCSLHVPFQAKTYTELQGKVKAGYFEPLPHF--YSKNLQDIITRCIQVDFTKRPSTWSL 299
E+ P+ +T + A + + S NLQD + RC+QV+ +R + L
Sbjct: 480 EMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADEL 539
Query: 300 LN 301
L+
Sbjct: 540 LS 541
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 86.3 bits (212), Expect = 7e-17
Identities = 82/368 (22%), Positives = 147/368 (39%), Gaps = 64/368 (17%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
+Y LL ++G GSFG V K ++ K++ + + E +LS N
Sbjct: 8 SYTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDL-ETGIDDITDIEQEVFMLSNCNSSN 66
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
+++++ D TL++ ME+ G +S +++ + + E+ + I+ ++L L
Sbjct: 67 VIQYYGCFVDGY--TLWILMEHMDGGSVSGLLKMGR-----LNEQVISIILREVLYGLNY 119
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H G IHRD+K NI L+ S
Sbjct: 120 LH----------------------GQNKIHRDIKAANILLSS--------------STGN 143
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KL DFG+A L + T+VGTP++M+PEV++ Y +DIWSLG E+ +
Sbjct: 144 VKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQQTSYGLAADIWSLGITAIEMANGIP 203
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQCRIC 308
P + ++ L +S +D ++ C+ ++ R WS +Q
Sbjct: 204 PRATMHPMRVIFEIPQSEPPKLDDHFSPTFRDFVSCCLDLNPNMR---WSAKELLQHPFI 260
Query: 309 RKALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQRVREILNGTSKPAATP 368
+ A ++ L+ E++L F + + E +N T KP P
Sbjct: 261 KSAGTVKDIIPLLVQKENKL-----------------FDDSDQSVLEETINNTLKPFEEP 303
Query: 369 LITGTGPV 376
+ G +
Sbjct: 304 IAEGNADI 311
>SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase
Length = 775
Score = 86.3 bits (212), Expect = 7e-17
Identities = 71/266 (26%), Positives = 117/266 (43%), Gaps = 46/266 (17%)
Query: 29 READNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHWDHDAKSNTLFLYM 88
RE +V+ V + + + ++ ++ E +L ++H N+++ D + LF+ +
Sbjct: 30 RETGQLAVVKPIVGWSELTSSQQARIEGELVLLRLIEHPNVLQLI--DVISAQEQLFVVV 87
Query: 89 EYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEP 148
EY G+L + + +++W QIL L CH KL
Sbjct: 88 EYMPGGELFDCMLRKGSFTEQDTAKFLW----QILCGLEYCH------KLH--------- 128
Query: 149 LKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFAT 208
+ HRDLKP N++L + IK+G+FG+A S+Q +
Sbjct: 129 -------ICHRDLKPENLYLDAHGS---------------IKIGEFGMA-SIQQPGKLLQ 165
Query: 209 TYVGTPYYMSPEVLRDQPYSPL-SDIWSLGCILYELCSLHVPFQAKTYTELQGKVKAGYF 267
T G+P+Y SPE++ + Y SDIWS G I + L + +PF L KV G F
Sbjct: 166 TSCGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALLTGKLPFDDDNIRSLLLKVCQGQF 225
Query: 268 EPLPHFYSKNLQDIITRCIQVDFTKR 293
E +P S Q ++ R + VD + R
Sbjct: 226 E-MPSNISPQAQHLLYRMLDVDSSTR 250
>Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 454
Score = 86.3 bits (212), Expect = 7e-17
Identities = 76/293 (25%), Positives = 128/293 (42%), Gaps = 51/293 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER----QQLISECAILSQLK 65
Y + EE+G G F VRK ++ K K ++ +++ R +++ E IL +++
Sbjct: 13 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIR 72
Query: 66 HDNIVEFFHWDHDAKSNT--LFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQIL 123
H NI+ HD N + L +E S G+L + +++ + E+ + + QIL
Sbjct: 73 HPNIITL----HDIFENKTDVVLILELVSGGELFDFLA----EKESLTEDEATQFLKQIL 124
Query: 124 MALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVD 183
+ H R + H DLKP NI L D +
Sbjct: 125 DGVHYLHSKR----------------------IAHFDLKPENIMLL-----------DKN 151
Query: 184 YSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
IKL DFG+A ++A EF + GTP +++PE++ +P +D+WS+G I Y L
Sbjct: 152 VPNPRIKLIDFGIAHKIEAGNEFKNIF-GTPEFVAPEIVNYEPLGLEADMWSIGVITYIL 210
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKN---LQDIITRCIQVDFTKR 293
S PF +T E + A ++ ++S +D I R + D +R
Sbjct: 211 LSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRR 263
>ECU08g1920 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 296
Score = 86.3 bits (212), Expect = 7e-17
Identities = 68/236 (28%), Positives = 104/236 (43%), Gaps = 41/236 (17%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
+++ LE+IG G++G V K N+V+ K++R + N I E +L LKH
Sbjct: 4 SFQKLEKIGEGTYGVVYKARERNTNRVVALKKIRLENENEGIPATTIREILLLKNLKHST 63
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
IVE D +N ++L EY DL + + + + V E +V ++ Q+L A+
Sbjct: 64 IVELS--DVIYNNNKMYLVFEYVEL-DLRRYLDRMSDEGRLVEEGFVRKMSQQLLTAMEY 120
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH + HRDLKP NI + ++
Sbjct: 121 CHSRN----------------------IFHRDLKPQNILVDPKEN--------------- 143
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLS-DIWSLGCILYEL 243
IKL DFGL ++ + TT V T +Y PE+L Y S D+WS CI+ E+
Sbjct: 144 IKLADFGLGRAAGIPLRTYTTEVVTLWYRPPELLLGCKYYDASVDVWSAACIMAEV 199
>CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 422
Score = 86.3 bits (212), Expect = 7e-17
Identities = 75/283 (26%), Positives = 120/283 (41%), Gaps = 46/283 (16%)
Query: 13 LEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKE--RQQLISECAILSQLKHDNIV 70
L IG+GSFG V +V + K+ K + H+ K + + +++ KH +V
Sbjct: 97 LTTIGKGSFGRVYQVRHKETKKIYAMKILSKEHIRKKNEVKHVMAERNVLINNFKHPFLV 156
Query: 71 EFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCH 130
H+ K L+ +++ + G+L ++ KH + Y +I AL H
Sbjct: 157 SL-HFSFQNKEK-LYFVLDHLNGGELFSHLQREKHFSESRSRFYA----AEIACALGYLH 210
Query: 131 YGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIK 190
+I+RDLKP N+ L DD K +
Sbjct: 211 EKN----------------------IIYRDLKPENLLL---DD------------KGYLV 233
Query: 191 LGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPF 250
L DFGL K + +T+ GTP Y++PE++ +PY D W LG +LYE+ PF
Sbjct: 234 LTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKPYDKTVDWWCLGSVLYEMIFGLPPF 293
Query: 251 QAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
+K + E+ K+ L H S ++IT +Q D +KR
Sbjct: 294 YSKDHNEMYDKIINQPLR-LKHNISVPCSELITGLLQKDRSKR 335
>CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 332
Score = 86.3 bits (212), Expect = 7e-17
Identities = 76/246 (30%), Positives = 111/246 (44%), Gaps = 54/246 (21%)
Query: 13 LEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEF 72
LE+IG G++G V K N ++ K++R + + E ++L +L+H N+V
Sbjct: 25 LEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKELQHPNVVGL 84
Query: 73 FHWDHDA---KSNTLFLYMEYCSKGDLSQMIRYYKHQ---RKYVPEEYVWRIMVQILMAL 126
+A + N LFL E+ LS ++ Y Q +Y+P E + QIL A+
Sbjct: 85 -----EAVIMQENRLFLIFEF-----LSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAM 134
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
CH R VIHRDLKP N+ + N A
Sbjct: 135 CFCHQRR----------------------VIHRDLKPQNLLVD------NNGA------- 159
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRD-QPYSPLSDIWSLGCILYELCS 245
IKL DFGLA+++ I T V T +Y +PE+L Q YS D+WS+GCI E+ +
Sbjct: 160 --IKLADFGLARAIGIPIRVYTHEVVTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMAT 217
Query: 246 LHVPFQ 251
FQ
Sbjct: 218 KKPLFQ 223
>At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 438
Score = 86.3 bits (212), Expect = 7e-17
Identities = 84/297 (28%), Positives = 129/297 (43%), Gaps = 51/297 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHW 75
IG+GSFG + K V V++ + + Q E +L +L+H NIV+F
Sbjct: 168 IGKGSFGEIVKAYWRG-TPVAVKRILPSLSDDRLVIQDFRHEVDLLVKLRHPNIVQFLGA 226
Query: 76 DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDL 135
+ K L L EY GDL Q Y K + P V ++ D+
Sbjct: 227 VTERKP--LMLITEYLRGGDLHQ---YLKEKGGLTPTTAV--------------NFALDI 267
Query: 136 SKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFG 195
++ T L ++ V+IHRDLKP N+ L S D+ +K+GDFG
Sbjct: 268 ARGMTY-------LHNEPNVIIHRDLKPRNVLLVN---------SSADH----LKVGDFG 307
Query: 196 LAKSLQAS----IEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQ 251
L+K ++ + T G+ YM+PEV + + Y D++S ILYE+ PF
Sbjct: 308 LSKLIKVQNSHDVYKMTGETGSYRYMAPEVFKHRRYDKKVDVFSFAMILYEMLEGEPPFA 367
Query: 252 AKTYTELQGKVKAGYFEPLPHFYSK----NLQDIITRCIQVDFTKRPSTWSLLNDIQ 304
E V G+ P F SK +L+++I +C D +RPS +L ++
Sbjct: 368 NHEPYEAAKHVSDGH---RPTFRSKGCTPDLRELIVKCWDADMNQRPSFLDILKRLE 421
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 86.3 bits (212), Expect = 7e-17
Identities = 82/308 (26%), Positives = 130/308 (41%), Gaps = 65/308 (21%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLK-HDN 68
+ L+E +G G++G V K ++ K + + E +++ E +L + H N
Sbjct: 32 FELIEVVGNGTYGQVYKGRHTKTGQLAAIKVM---DVTEDEEEEIKLEINVLKKYSNHRN 88
Query: 69 IVEFF----HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
I ++ K + L+L MEYC G ++ +++ K Q + EE++ I +IL
Sbjct: 89 IATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQS--LKEEWIAYICREILR 146
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
L H + VIHRD+K N+ LT NA
Sbjct: 147 GLSYLHSNK----------------------VIHRDIKGQNVLLT-------DNAE---- 173
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-----DQPYSPLSDIWSLGCI 239
+KL DFG++ L +I T++GTPY+M+PEV+ D Y SD+WSLG
Sbjct: 174 ----VKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGIT 229
Query: 240 LYE-------LCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTK 292
E LC LH P +A + + +SK I + D+ +
Sbjct: 230 ALEMAESQPPLCDLH-PMRALFLIPRNSPPRLKSKK-----WSKKFHGFIDTVLVKDYHQ 283
Query: 293 RPSTWSLL 300
RP T +LL
Sbjct: 284 RPYTENLL 291
>YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 397
Score = 85.9 bits (211), Expect = 1e-16
Identities = 75/285 (26%), Positives = 131/285 (45%), Gaps = 48/285 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHM-NAKERQQLISECAILSQLKHDN 68
+++L +G GSFG V + + + K ++ + K+ + E +LS + H
Sbjct: 87 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPF 146
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I+ + DA+ +F+ M+Y G+L ++R K QR P ++ +AL
Sbjct: 147 IIRMWGTFQDAQQ--IFMIMDYIEGGELFSLLR--KSQR--FPNPVAKFYAAEVCLAL-- 198
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
E L SK +I+RDLKP NI L ++N
Sbjct: 199 ------------------EYLHSKD--IIYRDLKPENILL-------DKNGH-------- 223
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
IK+ DFG AK + + T GTP Y++PEV+ +PY+ D WS G ++YE+ + +
Sbjct: 224 IKITDFGFAKYVP---DVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYT 280
Query: 249 PFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
PF + K+ P F++++++D+++R I D ++R
Sbjct: 281 PFYDSNTMKTYEKILNAELR-FPPFFNEDVKDLLSRLITRDLSQR 324
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 85.9 bits (211), Expect = 1e-16
Identities = 77/299 (25%), Positives = 121/299 (39%), Gaps = 45/299 (15%)
Query: 2 NRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAIL 61
+R + + + L+ IG+GSFG V K + +V+ K + E + + E +L
Sbjct: 12 SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAE-DEIEDIQQEITVL 70
Query: 62 SQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
SQ I +F KS L++ MEY G +++ + E Y+ I+ +
Sbjct: 71 SQCDSPYITRYF--GSYLKSTKLWIIMEYLGGGSALDLLKPGP-----LEETYIATILRE 123
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
IL L H R IHRD+K N+ L+ D
Sbjct: 124 ILKGLDYLHSERK----------------------IHRDIKAANVLLSEQGD-------- 153
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILY 241
+KL DFG+A L + T+VGTP++M+PEV++ Y +DIWSLG
Sbjct: 154 -------VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAI 206
Query: 242 ELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
EL P + + L +SK ++ + C+ D RP+ LL
Sbjct: 207 ELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELL 265
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 85.9 bits (211), Expect = 1e-16
Identities = 77/299 (25%), Positives = 121/299 (39%), Gaps = 45/299 (15%)
Query: 2 NRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAIL 61
+R + + + L+ IG+GSFG V K + +V+ K + E + + E +L
Sbjct: 12 SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAE-DEIEDIQQEITVL 70
Query: 62 SQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQ 121
SQ I +F KS L++ MEY G +++ + E Y+ I+ +
Sbjct: 71 SQCDSPYITRYF--GSYLKSTKLWIIMEYLGGGSALDLLKPGP-----LEETYIATILRE 123
Query: 122 ILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASD 181
IL L H R IHRD+K N+ L+ D
Sbjct: 124 ILKGLDYLHSERK----------------------IHRDIKAANVLLSEQGD-------- 153
Query: 182 VDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILY 241
+KL DFG+A L + T+VGTP++M+PEV++ Y +DIWSLG
Sbjct: 154 -------VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAI 206
Query: 242 ELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
EL P + + L +SK ++ + C+ D RP+ LL
Sbjct: 207 ELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELL 265
>7300559 [T] KOG4279 Serine/threonine protein kinase
Length = 1310
Score = 85.9 bits (211), Expect = 1e-16
Identities = 78/298 (26%), Positives = 127/298 (42%), Gaps = 59/298 (19%)
Query: 16 IGRGSFGSVRKVVREADNKVMVR-KEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFH 74
+G+G++G+V R+ +V + KEV N+++ Q L E + SQL+H NIV +
Sbjct: 585 LGKGTYGTVY-AARDKQTQVRIAIKEVP--EKNSQDVQPLHEEIKLHSQLRHRNIVRYLG 641
Query: 75 WDHDAKSNTLF-LYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
N F ++ME G LS ++ E W + +
Sbjct: 642 ---SCSENGFFKIFMEQVPGGSLSDLL------------ETKWGPL-------------K 673
Query: 134 DLSKLQTIYDAMEEPLKSKGYV----VIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
D Y ++ L+ Y+ ++HRD+K N+ + Y ++
Sbjct: 674 DNESTMAFYS--KQILEGLKYLHEQDIVHRDIKGDNVLVNTYSG--------------VV 717
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRD--QPYSPLSDIWSLGCILYELCSLH 247
K+ DFG +K L T+ GT YM+PEV+ + Y P +DIWS GC E+ +
Sbjct: 718 KISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGK 777
Query: 248 VPFQAKTYTELQGKVKAGYFEP---LPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
PF + + K G+++ +P S N ++ I RC + RPS LL D
Sbjct: 778 PPF-IELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLED 834
>7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 459
Score = 85.9 bits (211), Expect = 1e-16
Identities = 90/330 (27%), Positives = 146/330 (43%), Gaps = 61/330 (18%)
Query: 5 ERQPTYRLLEEIGRGSFGSVRKV--VREADNKVM--VRKEVRYG---HMNAKERQQLISE 57
E TY + ++G G++G VR V R M V+K + G N + ++++E
Sbjct: 152 EINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNE 211
Query: 58 CAILSQLKHDNIVEFFHWDHDA--KSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYV 115
I+ L H +V HD K +++++ +E+ GDL I K + + + Y
Sbjct: 212 AKIMKNLSHPCVVRM----HDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYF 267
Query: 116 WRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEF 175
+++ CH + L +G + HRDLKP N+ L D+E
Sbjct: 268 YQM----------CH--------------AVKYLHDRG--ITHRDLKPDNVLLETNDEE- 300
Query: 176 NQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL---RDQPYSPLSD 232
++K+ DFGL+K +Q T GTP Y++PEVL + Y+ D
Sbjct: 301 -----------TLLKVSDFGLSKFVQKD-SVMRTLCGTPLYVAPEVLITGGREAYTKKVD 348
Query: 233 IWSLGCILYELCSLHVPFQAKTYTELQGKVKAG---YFEPLPHFYSKNLQDIITRCIQVD 289
IWSLG +L+ S +PF + T ++K G Y P S+ + +I + + VD
Sbjct: 349 IWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVD 408
Query: 290 FTKRPSTWSLLNDIQCRICRKALDLEKFER 319
+RPS +L Q R A L+K +R
Sbjct: 409 PERRPSIDDVL---QSSWLRDAPMLQKAKR 435
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 85.9 bits (211), Expect = 1e-16
Identities = 77/304 (25%), Positives = 132/304 (43%), Gaps = 51/304 (16%)
Query: 9 TYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQL-KHD 67
T+ ++E IG+G++G V KV + D + V+ + +++ +E IL L H
Sbjct: 26 TWEIIETIGKGTYGKVYKVTNKRDGSLAA---VKILDPVSDMDEEIEAEYNILQFLPNHP 82
Query: 68 NIVEFFHWDHDAK---SNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
N+V+F+ + A L+L +E C+ G ++++++ + + E + I+ L+
Sbjct: 83 NVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALL 142
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
L H R +IHRD+K NI LT
Sbjct: 143 GLQHLHNNR----------------------IIHRDVKGNNILLT--------------- 165
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-----DQPYSPLSDIWSLGCI 239
++ +KL DFG++ L ++ T VGTP++M+PEV+ D Y D+WSLG
Sbjct: 166 TEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGIT 225
Query: 240 LYELCSLHVPFQAKTYTELQGKVKAGYFEPL--PHFYSKNLQDIITRCIQVDFTKRPSTW 297
EL P + K+ L P + + I++C+ DF +RPS
Sbjct: 226 AIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVT 285
Query: 298 SLLN 301
LL+
Sbjct: 286 HLLD 289
>Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 378
Score = 85.9 bits (211), Expect = 1e-16
Identities = 69/263 (26%), Positives = 114/263 (43%), Gaps = 45/263 (17%)
Query: 2 NRNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGH-MNAKERQQLISEC-A 59
N + + + L+ IG+GSFG V R+ D KV K ++ +N KE++ +++E
Sbjct: 36 NPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKVYAVKVLQKKIVLNRKEQKHIMAERNV 95
Query: 60 ILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIM 119
+L +KH +V H+ + L+ +++ + G+L ++ + + PE
Sbjct: 96 LLKNVKHPFLVGL-HYSFQT-TEKLYFVLDFVNGGELF----FHLQRERSFPEHRARFYA 149
Query: 120 VQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNA 179
+I AL H +++RDLKP NI +
Sbjct: 150 AEIASALGYLH----------------------SIKIVYRDLKPENILVDSVGH------ 181
Query: 180 SDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCI 239
+ L DFGL K A + TT+ GTP Y++PEV+R QPY D W LG +
Sbjct: 182 ---------VVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAV 232
Query: 240 LYELCSLHVPFQAKTYTELQGKV 262
LYE+ PF + E+ +
Sbjct: 233 LYEMLYGLPPFYCRDVAEMYDNI 255
>SPCC24B10.07 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 569
Score = 85.5 bits (210), Expect = 1e-16
Identities = 68/255 (26%), Positives = 120/255 (46%), Gaps = 46/255 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK-ERQQLISECAILSQLKHDN 68
+ LL+ +G+GSFG V +V + +++ K ++ H+ ++ E ++E +L+Q+ +
Sbjct: 230 FELLKVVGKGSFGKVMQVRKRDTSRIYALKTMKKAHIVSRSEVDHTLAERTVLAQVNNPF 289
Query: 69 IVEF-FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
IV F + K L+L + + + G+L ++ QR+ + Y + + L+
Sbjct: 290 IVPLKFSFQSPGK---LYLVLAFVNGGEL-----FHHLQREGCFDTYRAKFYIAELLVAL 341
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
+C + + VI+RDLKP NI L DY+
Sbjct: 342 ECLHE---------------------FNVIYRDLKPENILL--------------DYTGH 366
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
I L DFGL K A + T+ GTP Y++PE+L Y+ + D W+LG +LYE+ +
Sbjct: 367 IA-LCDFGLCKLNMAKTDRTNTFCGTPEYLAPELLLGHGYTKVVDWWTLGVLLYEMITGL 425
Query: 248 VPFQAKTYTELQGKV 262
PF + E+ K+
Sbjct: 426 PPFYDENINEMYRKI 440
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 85.5 bits (210), Expect = 1e-16
Identities = 73/288 (25%), Positives = 120/288 (41%), Gaps = 45/288 (15%)
Query: 13 LEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEF 72
LE+IG+GSFG V K + KV+ K + E + + E +LSQ + ++
Sbjct: 39 LEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE-DEIEDIQQEITVLSQCDSPYVTKY 97
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
+ K L++ MEY G ++ + + E + I+ +IL L H
Sbjct: 98 Y--GSYLKDTKLWIIMEYLGGGSALDLL-----EPGPLDETQIATILREILKGLDYLHSE 150
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
+ IHRD+K N+ L+ + + +KL
Sbjct: 151 KK----------------------IHRDIKAANVLLSEHGE---------------VKLA 173
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQA 252
DFG+A L + T+VGTP++M+PEV++ Y +DIWSLG EL P
Sbjct: 174 DFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSE 233
Query: 253 KTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
++ + L YSK L++ + C+ + + RP+ LL
Sbjct: 234 LHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELL 281
>Hs13376175 [R] KOG0589 Serine/threonine protein kinase
Length = 463
Score = 85.5 bits (210), Expect = 1e-16
Identities = 55/178 (30%), Positives = 86/178 (47%), Gaps = 25/178 (14%)
Query: 203 SIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKTYTELQGKV 262
S + ATT GTP+YMSPE L+ Q Y SDIWSL CILYE+C ++ F + + K+
Sbjct: 3 SCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKI 62
Query: 263 KAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL------NDIQCRICR------- 309
G LP Y K L I+ + + + RPS +L +Q +CR
Sbjct: 63 VEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILKIPYLDEQLQNLMCRYSEMTLE 122
Query: 310 -KALDLEKFERHLLNYEHE---------LTQVGEMLEQHATEMKRDFASAVDQRVREI 357
K LD +K H++N + L++V +M + +++ A D++ R++
Sbjct: 123 DKNLDCQKEAAHIINAMQKRIHLQTLRALSEVQKMTPRERMRLRK--LQAADEKARKL 178
>At5g25110 [T] KOG0583 Serine/threonine protein kinase
Length = 460
Score = 85.5 bits (210), Expect = 1e-16
Identities = 84/298 (28%), Positives = 133/298 (44%), Gaps = 65/298 (21%)
Query: 10 YRLLEEIGRGSFGSV---------RKVVREADNKVMVRKEVRYGHMNAKERQQLISECAI 60
Y + +G+G+FG V V + NK V++E G M +Q+ E +I
Sbjct: 15 YEMGRLLGKGTFGKVYYGKEITTGESVAIKIINKDQVKRE---GMM-----EQIKREISI 66
Query: 61 LSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV 120
+ ++H NIVE + A +F MEY G+L + K + + E+ +
Sbjct: 67 MRLVRHPNIVELK--EVMATKTKIFFIMEYVKGGEL-----FSKIVKGKLKEDSARKYFQ 119
Query: 121 QILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNAS 180
Q++ A+ CH S+G V HRDLKP N+ + D
Sbjct: 120 QLISAVDFCH--------------------SRG--VSHRDLKPENLLVDENGD------- 150
Query: 181 DVDYSKVIIKLGDFGLAKSLQASIE--FATTYVGTPYYMSPEVLRDQPYSPLS-DIWSLG 237
+K+ DFGL+ + ++ T GTP Y++PEVLR + Y DIWS G
Sbjct: 151 --------LKVSDFGLSALPEQILQDGLLHTQCGTPAYVAPEVLRKKGYDGAKGDIWSCG 202
Query: 238 CILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
ILY L + +PFQ + ++ K+ FE P ++S + +I++ + VD KR S
Sbjct: 203 IILYVLLAGFLPFQDENLMKMYRKIFKSEFE-YPPWFSPESKRLISKLLVVDPNKRIS 259
>At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 601
Score = 85.5 bits (210), Expect = 1e-16
Identities = 88/294 (29%), Positives = 130/294 (43%), Gaps = 53/294 (18%)
Query: 10 YRLLEEIGRGSFG-SVRKVVREADNK---VMVRKEVRYGHMNAKERQQLISECAILSQLK 65
Y L +E+GRG FG + ++ DNK V V+ + A + + E IL L
Sbjct: 148 YELGDEVGRGHFGYTCAAKFKKGDNKGQQVAVKVIPKAKMTTAIAIEDVRREVKILRALS 207
Query: 66 -HDNIVEFF--HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
H+N+ F+ + DHD +++ ME C G+L + R KY EE +M+QI
Sbjct: 208 GHNNLPHFYDAYEDHD----NVYIVMELCEGGEL--LDRILSRGGKYT-EEDAKTVMIQI 260
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
L + CH LQ V+HRDLKP N T +D
Sbjct: 261 LNVVAFCH-------LQG---------------VVHRDLKPENFLFTSKEDTSQ------ 292
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYE 242
+K DFGL+ ++ E VG+ YY++PEVL + YS +DIWS+G I+Y
Sbjct: 293 ------LKAIDFGLSDYVRPD-ERLNDIVGSAYYVAPEVLH-RSYSTEADIWSVGVIVYI 344
Query: 243 LCSLHVPFQAKTYTELQG---KVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
L PF A+T + + K + +P S +D + R + D KR
Sbjct: 345 LLCGSRPFWARTESGIFRAVLKADPSFDDPPWPLLSSEARDFVKRLLNKDPRKR 398
>YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 398
Score = 85.1 bits (209), Expect = 2e-16
Identities = 79/290 (27%), Positives = 130/290 (44%), Gaps = 58/290 (20%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVR-YGHMNAKERQQLISECAILSQLKHDN 68
+++L +G GSFG V + + + K ++ + + K+ + E +LS + H
Sbjct: 88 FQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPF 147
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I+ W S +F+ M+Y G+L ++R K QR P ++ +AL
Sbjct: 148 IIRM--WGTFQDSQQVFMVMDYIEGGELFSLLR--KSQR--FPNPVAKFYAAEVCLAL-- 199
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
E L SK +I+RDLKP NI L ++N
Sbjct: 200 ------------------EYLHSKD--IIYRDLKPENILL-------DKNGH-------- 224
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
IK+ DFG AK + + T GTP Y++PEV+ +PY+ D WS G ++YE+ + +
Sbjct: 225 IKITDFGFAKYVP---DVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYT 281
Query: 249 PF----QAKTYTE-LQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
PF KTY L ++K P F+ + QD++ + I D ++R
Sbjct: 282 PFYNSNTMKTYENILNAELK------FPPFFHPDAQDLLKKLITRDLSER 325
>SPCC74.03c [T] KOG0583 Serine/threonine protein kinase
Length = 576
Score = 85.1 bits (209), Expect = 2e-16
Identities = 77/295 (26%), Positives = 128/295 (43%), Gaps = 48/295 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVR-EADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
Y + E +G GSFG V+ + KV ++ R + ++ E + L L+H +
Sbjct: 34 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPH 93
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I++ + D + + +EY G+L Y ++K + E+ R QI+ A+
Sbjct: 94 IIKLY--DVITTPTDIVMVIEYAG-GELFD----YIVEKKRMTEDEGRRFFQQIICAIEY 146
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH + ++HRDLKP N+ L DD N
Sbjct: 147 CHRHK----------------------IVHRDLKPENLLL---DDNLN------------ 169
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYELCSLH 247
+K+ DFGL+ ++ F T G+P Y +PEV+ + Y+ P D+WS G +LY +
Sbjct: 170 VKIADFGLS-NIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGR 228
Query: 248 VPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLND 302
+PF + L KV + + +P F S Q +I R I D +R + + D
Sbjct: 229 LPFDDEFIPNLFKKVNSCVY-VMPDFLSPGAQSLIRRMIVADPMQRITIQEIRRD 282
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 85.1 bits (209), Expect = 2e-16
Identities = 72/298 (24%), Positives = 130/298 (43%), Gaps = 55/298 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMN------AKERQQLISECAILSQLKHDNI 69
IG GSFG V + + ++M K+V ++ AK L E A+L +L H++I
Sbjct: 103 IGSGSFGQVYLGMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHI 162
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V++ + S+ L +++EY G ++ ++ Y E V + Q L L
Sbjct: 163 VQYL--GSNLNSDHLNIFLEYVPGGSVAGLLTMYGS----FEETLVKNFIKQTLKGL--- 213
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
E L S+G ++HRD+K NI + +K I
Sbjct: 214 -----------------EYLHSRG--IVHRDIKGANILVD---------------NKGKI 239
Query: 190 KLGDFGLAKSLQASIEFATT------YVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
K+ DFG++K L+ + T + G+ ++M+PEV++ ++ +DIWSLGC++ E+
Sbjct: 240 KISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEM 299
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
+ P+ + ++ P S + D + + +D RP+ LL+
Sbjct: 300 LTSKHPYPNCDQMQAIFRIGENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLS 357
>Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 878
Score = 85.1 bits (209), Expect = 2e-16
Identities = 91/314 (28%), Positives = 137/314 (42%), Gaps = 57/314 (18%)
Query: 14 EEIGRGSFGSV-----RKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
E +G G FG V RK R+ KV+ ++R+ K+ QL +E AIL L+H
Sbjct: 555 EVLGSGQFGVVYGGKHRKTGRDVAVKVI--DKLRFP---TKQESQLRNEVAILQSLRHPG 609
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
IV + +F+ ME GD+ +MI ++ +PE ++ QIL+AL
Sbjct: 610 IVNLECMFETPEK--VFVVMEKLH-GDMLEMI--LSSEKGRLPERLTKFLITQILVALRH 664
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
H+ ++H DLKP N+ L D F Q
Sbjct: 665 LHFKN----------------------IVHCDLKPENVLLASADP-FPQ----------- 690
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHV 248
+KL DFG A+ + F + VGTP Y++PEVL +Q Y+ D+WS+G I+Y S
Sbjct: 691 VKLCDFGFARIIGEK-SFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTF 749
Query: 249 PFQAKTYTELQGKVKAGYF----EPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDIQ 304
PF ++ +++ F P H S D+I +QV KR S L+
Sbjct: 750 PFNED--EDINDQIQNAAFMYPASPWSHI-SAGAIDLINNLLQVKMRKRYSVDKSLSHPW 806
Query: 305 CRICRKALDLEKFE 318
+ + LDL + E
Sbjct: 807 LQEYQTWLDLRELE 820
>At3g10540 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 483
Score = 85.1 bits (209), Expect = 2e-16
Identities = 85/299 (28%), Positives = 135/299 (44%), Gaps = 74/299 (24%)
Query: 22 GSVRKVVR--EADN------KVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFF 73
GS KVVR + DN K+M +K + + A + + I +L QL+H IV+ F
Sbjct: 51 GSYSKVVRAKKKDNGTVYALKIMDKKFITKENKTAYVKLERI----VLDQLEHPGIVKLF 106
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMI----RYYKHQRKYVPEEYVWRIMVQILMALFKC 129
D +S L++ +E C G+L I R + + ++ E V
Sbjct: 107 FTFQDTQS--LYMALESCEGGELFDQITRKGRLSEDEARFYSAEVV-------------- 150
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
DA+E + + G +IHRD+KP N+ LT D I
Sbjct: 151 -------------DALEY-IHNMG--LIHRDIKPENLLLT-LDGH--------------I 179
Query: 190 KLGDFGLAKSLQ----------ASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCI 239
K+ DFG K +Q AS + A T+VGT Y+ PEVL P + +D+W+LGC
Sbjct: 180 KIADFGSVKPMQDSQITVLPNAASDDKACTFVGTAAYVPPEVLNSSPATFGNDLWALGCT 239
Query: 240 LYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWS 298
LY++ S PF+ + + ++ A + P+ +S+ +D+I R + D ++RP S
Sbjct: 240 LYQMLSGTSPFKDASEWLIFQRIIARDIK-FPNHFSEAARDLIDRLLDTDPSRRPGAGS 297
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 85.1 bits (209), Expect = 2e-16
Identities = 84/313 (26%), Positives = 141/313 (44%), Gaps = 61/313 (19%)
Query: 3 RNERQPT--YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNA-KERQQ-----L 54
R E P+ +R E IG G+FG V + +++ K+V +A KE+ Q L
Sbjct: 59 RKEEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIREL 118
Query: 55 ISECAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEY 114
E +L L H NIV + + S++L + ME+ G +S ++ + PE
Sbjct: 119 EEEVQLLKNLSHPNIVRYLGTVRE--SDSLNILMEFVPGGSISSLLEKFGS----FPEPV 172
Query: 115 VWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDE 174
+ Q+L+ L E L + G ++HRD+K NI +
Sbjct: 173 IIMYTKQLLLGL--------------------EYLHNNG--IMHRDIKGANILVD----- 205
Query: 175 FNQNASDVDYSKVIIKLGDFGLAKSLQ--ASIEFATTYVGTPYYMSPEVLRDQPYSPLSD 232
+K I+L DFG +K + A++ A + GTPY+M+PEV+ +S +D
Sbjct: 206 ----------NKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGHSFSAD 255
Query: 233 IWSLGCILYELCSLHVPFQAKTYTELQ-----GKVKAGYFEPLPHFYSKNLQDIITRCIQ 287
IWS+GC + E+ + P+ ++ Y + G+ KA P+P S +D + +C+
Sbjct: 256 IWSVGCTVIEMATGKPPW-SEQYQQFAAVLHIGRTKA--HPPIPEDLSPEAKDFLMKCLH 312
Query: 288 VDFTKRPSTWSLL 300
+ + R S LL
Sbjct: 313 KEPSLRLSATELL 325
>At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 345
Score = 85.1 bits (209), Expect = 2e-16
Identities = 78/260 (30%), Positives = 122/260 (46%), Gaps = 43/260 (16%)
Query: 36 MVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGD 95
MVR AK QQ SE A+LS+L H NIV+F K + EY S+G+
Sbjct: 69 MVRIPTHKEETRAKLEQQFKSEVALLSRLFHPNIVQFIA--ACKKPPVYCIITEYMSQGN 126
Query: 96 LSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYV 155
L R Y+ ++ + + ++ ++ L D+S+ E L S+G
Sbjct: 127 L----------RMYLNKKEPYSLSIETVLRL-----ALDISRGM-------EYLHSQG-- 162
Query: 156 VIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPY 215
VIHRDLK N+ L +DE +K+ DFG + L+ A +GT
Sbjct: 163 VIHRDLKSNNLLL---NDEMR------------VKVADFGTS-CLETQCREAKGNMGTYR 206
Query: 216 YMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAKTYTELQGKV-KAGYFEPLPHFY 274
+M+PE+++++PY+ D++S G +L+EL + +PFQ T + V + PLP
Sbjct: 207 WMAPEMIKEKPYTRKVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASC 266
Query: 275 SKNLQDIITRCIQVDFTKRP 294
L +I RC + +KRP
Sbjct: 267 QPALAHLIKRCWSENPSKRP 286
>At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 422
Score = 85.1 bits (209), Expect = 2e-16
Identities = 80/295 (27%), Positives = 129/295 (43%), Gaps = 62/295 (21%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKER---QQLISECAILSQLKHDNIVEF 72
+GRGS GSV + + AD KEV ++ QQ+ A+LSQL+H NIV +
Sbjct: 159 LGRGSLGSVYEGI-SADGDFFAFKEVSLLDQGSQAHEWIQQVEGGIALLSQLQHQNIVRY 217
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
D + L++++E ++G L ++ +QR + + V QIL L H
Sbjct: 218 RGTTKD--ESNLYIFLELVTQGSLRKL-----YQRNQLGDSVVSLYTRQILDGLKYLH-- 268
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
KG+ IHR++K N+ + + +KL
Sbjct: 269 ------------------DKGF--IHRNIKCANVLVD---------------ANGTVKLA 293
Query: 193 DFGLAKSLQASIEFATTYVGTPYY--MSPEVLRDQP----YSPLSDIWSLGCILYELCSL 246
DFGLAK + + TPY+ M+PEV+ + Y +DIWSLGC + E+ +
Sbjct: 294 DFGLAKVM--------SLWRTPYWNWMAPEVILNPKDYDGYGTPADIWSLGCTVLEMLTG 345
Query: 247 HVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
+P+ + G +P S + +D I C++V+ +RP+ LLN
Sbjct: 346 QIPYSDLEIGTALYNIGTGKLPKIPDILSLDARDFILTCLKVNPEERPTAAELLN 400
>Hs5453964 [T] KOG0583 Serine/threonine protein kinase
Length = 550
Score = 84.7 bits (208), Expect = 2e-16
Identities = 82/292 (28%), Positives = 135/292 (46%), Gaps = 55/292 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y L + +G G+FG V+ E K++ R+++R + K R+++ + L
Sbjct: 18 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQN----LKLF 73
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+H +I++ + + + +F+ MEY S G+L I K+ R + E+ R+ QIL
Sbjct: 74 RHPHIIKLYQVI--STPSDIFMVMEYVSGGELFDYI--CKNGR--LDEKESRRLFQQILS 127
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
+ CH ++V+HRDLKP N+ L + NA
Sbjct: 128 GVDYCHR----------------------HMVVHRDLKPENVLLDAH-----MNA----- 155
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYS-PLSDIWSLGCILYEL 243
K+ DFGL+ ++ + EF T G+P Y +PEV+ + Y+ P DIWS G ILY L
Sbjct: 156 -----KIADFGLS-NMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYAL 209
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
+PF L K+ G F P + + ++ ++ +QVD KR S
Sbjct: 210 LCGTLPFDDDHVPTLFKKICDGIFY-TPQYLNPSVISLLKHMLQVDPMKRAS 260
>7297680 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 297
Score = 84.7 bits (208), Expect = 2e-16
Identities = 69/246 (28%), Positives = 107/246 (43%), Gaps = 48/246 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ +E+IG G++G V K +++ K++R + I E ++L +LKH+NI
Sbjct: 4 FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENI 63
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQ---RKYVPEEYVWRIMVQILMAL 126
V D + N ++L E+ LS ++ Y K++ E V + QI A+
Sbjct: 64 VCL--EDVLMEENRIYLIFEF-----LSMDLKKYMDSLPVDKHMESELVRSYLYQITSAI 116
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
CH R V+HRDLKP N+ +
Sbjct: 117 LFCHRRR----------------------VLHRDLKPQNLLID---------------KS 139
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQP-YSPLSDIWSLGCILYELCS 245
+IK+ DFGL +S + T + T +Y +PEVL P YS DIWS+GCI E+ +
Sbjct: 140 GLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMAT 199
Query: 246 LHVPFQ 251
FQ
Sbjct: 200 RKPLFQ 205
>YGL158w [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 512
Score = 84.3 bits (207), Expect = 3e-16
Identities = 83/323 (25%), Positives = 136/323 (41%), Gaps = 62/323 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVV---READNKVMVRKEVRYG-----------HMNAKERQQLI 55
Y+LL +IG G+F V K V + V ++ ++ G + R++++
Sbjct: 121 YKLLNKIGEGAFSRVFKAVGINTDDQAPVAIKAIIKKGISSDAILKGNDRIQGSSRKKVL 180
Query: 56 SECAILSQLKHDN--IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEE 113
+E AI + +N +F + A N +L E + G++ I Q E+
Sbjct: 181 NEVAIHKLVSKNNPHCTKFIAFQESA--NYYYLVTELVTGGEIFDRIV----QLTCFSED 234
Query: 114 YVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLT---- 169
++ Q+ +A+ HY ++HRD+KP N+
Sbjct: 235 LARHVITQVAIAIKHMHY----------------------MGIVHRDVKPENLLFEPIPF 272
Query: 170 -GYD------DEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL 222
G D DEF ++KL DFGLAK L+ + A T GT Y++ EV
Sbjct: 273 YGLDGDMQKEDEFTLGVGGGGIG--LVKLMDFGLAKKLRNNT--AKTPCGTIEYVASEVF 328
Query: 223 RDQPYSPLSDIWSLGCILYELCSLHVPFQAKTYTELQGKVKAGYFEPLPHFY---SKNLQ 279
+ YS D+WS+GC+L+ L + PF K L K+ G +E L ++ S +
Sbjct: 329 TSKRYSMKVDMWSIGCVLFTLLCGYPPFYEKNEKTLLKKISRGDYEFLAPWWDNISSGAK 388
Query: 280 DIITRCIQVDFTKRPSTWSLLND 302
+ +T ++VD KR LND
Sbjct: 389 NAVTHLLEVDPNKRYDIDDFLND 411
>Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 84.3 bits (207), Expect = 3e-16
Identities = 81/287 (28%), Positives = 130/287 (45%), Gaps = 45/287 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +G G+F V + K++ K + + KE + +E A+L ++KH NI
Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHPNI 78
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V D L+L M+ S G+L I ++ + E R++ Q+L A+
Sbjct: 79 VALD--DIYESGGHLYLIMQLVSGGELFDRIV----EKGFYTERDASRLIFQVLDAVKYL 132
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H DL ++HRDLKP N+ D++ SK++I
Sbjct: 133 H---DLG-------------------IVHRDLKPENLLYYSLDED----------SKIMI 160
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
DFGL+K ++ +T GTP Y++PEVL +PYS D WS+G I Y L + P
Sbjct: 161 S--DFGLSK-MEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPP 217
Query: 250 FQAKTYTELQGKV-KAGYFEPLPHF--YSKNLQDIITRCIQVDFTKR 293
F + +L ++ KA Y P++ S + +D I ++ D KR
Sbjct: 218 FYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKR 264
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 84.3 bits (207), Expect = 3e-16
Identities = 73/291 (25%), Positives = 122/291 (41%), Gaps = 52/291 (17%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFF 73
E IGRGSFG V K + +V+ K + E + + E +LSQ + ++F
Sbjct: 36 ERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAE-DEIEDIQQEIQVLSQCDSQYVTKYF 94
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
K + L++ MEY G + + K + E ++ I+ +IL L H R
Sbjct: 95 --GSFLKGSKLWIIMEYLGGGSALDLTKSGK-----LDESHIAVILREILKGLEYLHSER 147
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
IHRD+K N+ ++ + D +K+ D
Sbjct: 148 K----------------------IHRDIKAANVLVSEHGD---------------VKVAD 170
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG+A L +++ T+VG+P++M+PE+++ Y +DIWSLG EL + P
Sbjct: 171 FGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDL 230
Query: 254 TYTELQGKVKAGYFEPLPHF----YSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ + P P +SK ++ + C+ D RPS +LL
Sbjct: 231 HPMRVLFLIPK---NPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLL 278
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 84.3 bits (207), Expect = 3e-16
Identities = 73/291 (25%), Positives = 122/291 (41%), Gaps = 52/291 (17%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFF 73
E IGRGSFG V K + +V+ K + E + + E +LSQ + ++F
Sbjct: 38 ERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAE-DEIEDIQQEIQVLSQCDSQYVTKYF 96
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
K + L++ MEY G + + K + E ++ I+ +IL L H R
Sbjct: 97 --GSFLKGSKLWIIMEYLGGGSALDLTKSGK-----LDESHIAVILREILKGLEYLHSER 149
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
IHRD+K N+ ++ + D +K+ D
Sbjct: 150 K----------------------IHRDIKAANVLVSEHGD---------------VKVAD 172
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG+A L +++ T+VG+P++M+PE+++ Y +DIWSLG EL + P
Sbjct: 173 FGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDL 232
Query: 254 TYTELQGKVKAGYFEPLPHF----YSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ + P P +SK ++ + C+ D RPS +LL
Sbjct: 233 HPMRVLFLIPK---NPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLL 280
>CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 336
Score = 84.3 bits (207), Expect = 3e-16
Identities = 84/311 (27%), Positives = 134/311 (43%), Gaps = 65/311 (20%)
Query: 3 RNERQPTYRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGH----MNAKERQQ 53
R + + Y + IG+G+F SV R+ D KV + +++ E++
Sbjct: 50 RQDIEKQYEIGAIIGKGNFSSVHLTRRKEDGTKCALKVRYQSTLQFSFPSKFFQQVEKRA 109
Query: 54 LISEC-------AILSQLKHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQ 106
+ +C +LS ++HD+I+ D + N F+ E+ GDL + IR K+
Sbjct: 110 MRGKCFFVDNEVEMLSLIQHDHIISII--DAFSTENQYFIVFEHAQYGDLYETIR--KNG 165
Query: 107 RKYVPEEYVWRIMVQILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNI 166
R P+ + I +Q+ AL H V+HRD+KP N+
Sbjct: 166 RIEEPDAAI--ITLQVASALNYLHERN----------------------VVHRDVKPENL 201
Query: 167 FLTGYDDEFNQNASDVDYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQP 226
L D+F+ +KL DFGLA + + GTP Y +PEVLR+
Sbjct: 202 LLV---DKFS------------VKLCDFGLACHILGPLY---RICGTPTYCAPEVLRETG 243
Query: 227 YSPLSDIWSLGCILYELCSLHVPFQAKTYT---ELQGKVKAGYFEPLPHFYSKNLQDIIT 283
YS DIWSLG +LY + + PF+A T +L + K P S +D+++
Sbjct: 244 YSTRCDIWSLGVVLYVMLVGYAPFRAPDQTRLFKLIMQAKPNLDMPEWKGISLKAKDLVS 303
Query: 284 RCIQVDFTKRP 294
R + +RP
Sbjct: 304 RLMNKTEERRP 314
>At3g20410 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 541
Score = 84.3 bits (207), Expect = 3e-16
Identities = 85/297 (28%), Positives = 126/297 (41%), Gaps = 49/297 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAK-ERQQLISECAILSQLK-HD 67
Y L +E+GRG FG + K K + + K ++ + E I+ L
Sbjct: 91 YTLGKELGRGQFGVTYLCTENSTGKKYACKSISKKKLVTKADKDDMRREIQIMQHLSGQP 150
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
NIVEF D K+ + L ME C+ G+L I H E + QI+ +
Sbjct: 151 NIVEFKGAYEDEKA--VNLVMELCAGGELFDRIIAKGHYT----ERAAASVCRQIVNVVK 204
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH+ V+HRDLKP N L+ D+ K
Sbjct: 205 ICHF----------------------MGVLHRDLKPENFLLSSKDE------------KA 230
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
+IK DFGL+ ++ + VG+ YY++PEVLR + Y DIWS G ILY L S
Sbjct: 231 LIKATDFGLSVFIEEGKVYRDI-VGSAYYVAPEVLRRR-YGKEVDIWSAGIILYILLSGV 288
Query: 248 VPFQAKTYTELQGKVKAGYF----EPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
PF A+T + + G+ +P P S + +D++ R + D +R S +L
Sbjct: 289 PPFWAETEKGIFDAILEGHIDFESQPWPSI-SSSAKDLVRRMLTADPKRRISAADVL 344
>7299536 [D] KOG0580 Serine/threonine protein kinase
Length = 411
Score = 84.3 bits (207), Expect = 3e-16
Identities = 72/274 (26%), Positives = 122/274 (44%), Gaps = 49/274 (17%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHM--NAKERQQLISECAILSQLKHDNIVEFF 73
+GRG FG+V + RE +++ +V +V + + Q+ E I S L+H +I+ +
Sbjct: 160 LGRGKFGNVY-LAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLY 218
Query: 74 HWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGR 133
+ HD ++L +EY +G L ++ +R +E +Q L + + R
Sbjct: 219 AYFHD--DVRIYLILEYAPQGTLFNALQAQPMKRF---DERQSATYIQALCSALLYLHER 273
Query: 134 DLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
D +IHRD+KP N+ L K ++K+ D
Sbjct: 274 D---------------------IIHRDIKPENLLLG---------------HKGVLKIAD 297
Query: 194 FGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQAK 253
FG S+ T GT Y+ PE+++ +P++ D+WSLG + +EL H PF +K
Sbjct: 298 FGW--SVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSK 355
Query: 254 TYTELQGKV-KAGYFEPLPHFYSKNLQDIITRCI 286
Y E K+ K Y LP SK +I++ +
Sbjct: 356 NYDETYKKILKVDY--KLPEHISKAASHLISKLL 387
>Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 556
Score = 84.0 bits (206), Expect = 4e-16
Identities = 80/296 (27%), Positives = 133/296 (44%), Gaps = 51/296 (17%)
Query: 3 RNERQPTYRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLIS-ECAIL 61
R +R ++ + +G GSF +V A ++ K + H+ + + ++ E ++
Sbjct: 75 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 134
Query: 62 SQLKHDNIVE-FFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMV 120
S+L H V+ +F + D K L+ + Y G+L + IR + Y
Sbjct: 135 SRLDHPFFVKLYFTFQDDEK---LYFGLSYAKNGELLKYIRKIGSFDETCTRFYT----A 187
Query: 121 QILMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNAS 180
+I+ AL E L KG +IHRDLKP NI L
Sbjct: 188 EIVSAL--------------------EYLHGKG--IIHRDLKPENILLN----------- 214
Query: 181 DVDYSKVIIKLGDFGLAKSL--QASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGC 238
+ I++ DFG AK L ++ A ++VGT Y+SPE+L ++ SD+W+LGC
Sbjct: 215 ----EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGC 270
Query: 239 ILYELCSLHVPFQA-KTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKR 293
I+Y+L + PF+A Y Q +K Y P + +D++ + + +D TKR
Sbjct: 271 IIYQLVAGLPPFRAGNEYLIFQKIIKLEY--DFPEKFFPKARDLVEKLLVLDATKR 324
>Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase
Length = 735
Score = 84.0 bits (206), Expect = 4e-16
Identities = 79/279 (28%), Positives = 128/279 (45%), Gaps = 53/279 (18%)
Query: 10 YRLLEEIGRGSFGS---VRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
+ LL+ +G+GSFG VRKV R + K ++ + ++R + E IL+ + H
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 121
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMAL 126
+V+ H+ + L+L +++ GDL + + EE V + ++ + L
Sbjct: 122 PFVVK-LHYAFQTEGK-LYLILDFLRGGDLFTRL----SKEVMFTEEDVKFYLAELALGL 175
Query: 127 FKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSK 186
+ L S G +I+RDLKP NI L D+E +
Sbjct: 176 --------------------DHLHSLG--IIYRDLKPENILL---DEEGH---------- 200
Query: 187 VIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSL 246
IKL DFGL+K + A ++ GT YM+PEV+ Q +S +D WS G +++E+ +
Sbjct: 201 --IKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTG 258
Query: 247 HVPFQAKTYTE---LQGKVKAGYFEPLPHFYSKNLQDII 282
+PFQ K E L K K G +P F S Q ++
Sbjct: 259 SLPFQGKDRKETMTLILKAKLG----MPQFLSTEAQSLL 293
Score = 71.6 bits (174), Expect = 2e-12
Identities = 75/286 (26%), Positives = 123/286 (42%), Gaps = 50/286 (17%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + E IG GS+ ++ V +A N K + + E +++ L +H NI
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEIL-----LRYGQHPNI 472
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ D K ++L E G+L I ++K+ E
Sbjct: 473 ITLKDVYDDGKH--VYLVTELMRGGELLDKIL----RQKFFSE----------------- 509
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
R+ S + E L S+G V+HRDLKP NI Y DE + +
Sbjct: 510 ---REASFVLHTIGKTVEYLHSQG--VVHRDLKPSNIL---YVDESG--------NPECL 553
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVP 249
++ DFG AK L+A T T +++PEVL+ Q Y DIWSLG +LY + + + P
Sbjct: 554 RICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTP 613
Query: 250 F---QAKTYTELQGKVKAGYFEPLP---HFYSKNLQDIITRCIQVD 289
F + T E+ ++ +G F + S+ +D++++ + VD
Sbjct: 614 FANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVD 659
>Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 400
Score = 84.0 bits (206), Expect = 4e-16
Identities = 72/252 (28%), Positives = 115/252 (45%), Gaps = 49/252 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKE--RQQLISECAILSQLKHD 67
+ + E+G G+ G V KV +M RK + H+ K R Q+I E +L +
Sbjct: 72 FERISELGAGNGGVVTKVQHRPSGLIMARKLI---HLEIKPAIRNQIIRELQVLHECNSP 128
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
IV F+ + + + ME+ G L Q+++ + K +PEE + ++ + +L
Sbjct: 129 YIVGFYGAFYS--DGEISICMEHMDGGSLDQVLK----EAKRIPEEILGKVSIAVL---- 178
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
R L+ L+ + + ++HRD+KP NI + S+
Sbjct: 179 -----RGLAYLR------------EKHQIMHRDVKPSNILVN---------------SRG 206
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLH 247
IKL DFG++ L S+ A ++VGT YM+PE L+ YS SDIWS+G L EL
Sbjct: 207 EIKLCDFGVSGQLIDSM--ANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGR 264
Query: 248 VPFQAKTYTELQ 259
P EL+
Sbjct: 265 YPIPPPDAKELE 276
>At5g66850 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 84.0 bits (206), Expect = 4e-16
Identities = 83/296 (28%), Positives = 120/296 (40%), Gaps = 55/296 (18%)
Query: 16 IGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQ---QLISECAILSQLKHDNIVEF 72
IGRG+FGSV + KEV + K + QL E +LS L+H NIV++
Sbjct: 11 IGRGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQLEQEIKLLSNLQHPNIVQY 70
Query: 73 FHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
F + + F+Y+EY G +++ IR + + E V IL L H
Sbjct: 71 F--GSETVEDRFFIYLEYVHPGSINKYIRDHCGT---MTESVVRNFTRHILSGLAYLHNK 125
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
+ +HRD+K N+ VD S V+ KL
Sbjct: 126 K----------------------TVHRDIKGANLL--------------VDASGVV-KLA 148
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLS--------DIWSLGCILYELC 244
DFG+AK L + G+PY+M+PEVL S DIWSLGC + E+
Sbjct: 149 DFGMAKHLTGQ-RADLSLKGSPYWMAPEVLMQAVMQKDSNPDLAFAVDIWSLGCTIIEMF 207
Query: 245 SLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLL 300
+ P+ KV P+P S +D + C Q + +RP+ LL
Sbjct: 208 TGKPPWSEFEGAAAMFKVMRD-SPPIPESMSPEGKDFLRLCFQRNPAERPTASMLL 262
>At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 821
Score = 84.0 bits (206), Expect = 4e-16
Identities = 76/293 (25%), Positives = 135/293 (45%), Gaps = 49/293 (16%)
Query: 14 EEIGRGSFGSVRKVVREADN---KVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIV 70
E+IG GSFG+V + + K+++ ++ +A+ + + E AI+ +L+H NIV
Sbjct: 555 EKIGAGSFGTVHRAEWHGSDVAVKILMEQD-----FHAERVNEFLREVAIMKRLRHPNIV 609
Query: 71 EFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCH 130
F + L + EY S+G L +++ + R+ + E
Sbjct: 610 LFM--GAVTQPPNLSIVTEYLSRGSLYRLL-HKSGAREQLDER----------------- 649
Query: 131 YGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIK 190
R LS + M L ++ ++HRDLK N+ + K +K
Sbjct: 650 --RRLSMAYDVAKGMNY-LHNRNPPIVHRDLKSPNLLVD---------------KKYTVK 691
Query: 191 LGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPF 250
+ DFGL++ ++ + + GTP +M+PEVLRD+P + SD++S G IL+EL +L P+
Sbjct: 692 VCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPW 751
Query: 251 QAKTYTELQGKV--KAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
++ V K E +P + + II C + KRPS ++++
Sbjct: 752 GNLNPAQVVAAVGFKCKRLE-IPRNLNPQVAAIIEGCWTNEPWKRPSFATIMD 803
>At4g18700 [T] KOG0583 Serine/threonine protein kinase
Length = 489
Score = 84.0 bits (206), Expect = 4e-16
Identities = 90/367 (24%), Positives = 161/367 (43%), Gaps = 62/367 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y + + +G G+F V N KV+ +++V G + A ++++ +IL ++
Sbjct: 26 YEMGKLLGHGTFAKVYLARNVKTNESVAIKVIDKEKVLKGGLIAHIKREI----SILRRV 81
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
+H NIV+ F + A ++ MEY G+L + K + + EE + Q++
Sbjct: 82 RHPNIVQLF--EVMATKAKIYFVMEYVRGGEL-----FNKVAKGRLKEEVARKYFQQLIS 134
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
A+ CH ++G V HRDLKP N+ L D+ N SD
Sbjct: 135 AVTFCH--------------------ARG--VYHRDLKPENLLL---DENGNLKVSDFGL 169
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLS-DIWSLGCILYEL 243
S V ++ GL T+ GTP Y++PEVL + Y DIWS G IL+ L
Sbjct: 170 SAVSDQIRQDGLFH----------TFCGTPAYVAPEVLARKGYDAAKVDIWSCGVILFVL 219
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLNDI 303
+ ++PF + + K+ G F P ++S L ++++ ++ + KR + ++ +
Sbjct: 220 MAGYLPFHDRNVMAMYKKIYRGEFR-CPRWFSTELTRLLSKLLETNPEKRFTFPEIMENS 278
Query: 304 QCRICRKALDLEKFERHLLNYEHELTQVGEMLEQHATEMKRDFASAVDQ----RVREILN 359
+ K + + L N + + LE + E RD A++ + R +
Sbjct: 279 WFKKGFKHIKFYVEDDKLCNVVDD-----DELESDSVESDRDSAASESEIEYLEPRRRVG 333
Query: 360 GTSKPAA 366
G +PA+
Sbjct: 334 GLPRPAS 340
>At3g53930 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 691
Score = 84.0 bits (206), Expect = 4e-16
Identities = 68/219 (31%), Positives = 98/219 (44%), Gaps = 36/219 (16%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y + +IG GSF V + V+ KE+ +N K ++ L+SE IL ++ H NI
Sbjct: 20 YAVGRQIGSGSFSVVWEGRHLVHGTVVAIKEIAMARLNKKLQESLMSEIIILRKINHPNI 79
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ F D + L +EYC GDLS Y H+ VPE M+Q+
Sbjct: 80 IRFI--DMIEAPGKINLVLEYCKGGDLSM----YIHKHGSVPEATAKHFMLQL------- 126
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQN-ASDVDYSKVI 188
+ LQ + D +IHRDLKP + QN D +
Sbjct: 127 -----AAGLQVLRDNN----------IIHRDLKPQVLSF------LKQNLLLSTDDNDAA 165
Query: 189 IKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY 227
+K+ DFG A+SLQ A T G+P YM+PE+++ Q Y
Sbjct: 166 LKIADFGFARSLQPR-GLAETLCGSPLYMAPEIMQLQKY 203
>Hs4826675 [UT] KOG0662 Cyclin-dependent kinase CDK5
Length = 292
Score = 83.6 bits (205), Expect = 5e-16
Identities = 68/241 (28%), Positives = 102/241 (42%), Gaps = 44/241 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y LE+IG G++G+V K ++++ K VR + + E +L +LKH NI
Sbjct: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
V H K L L E+C + + +Y+ + E V + Q+L L C
Sbjct: 64 VRLHDVLHSDKK--LTLVFEFCDQ----DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H V+HRDLKP N+ + N+N +
Sbjct: 118 HSRN----------------------VLHRDLKPQNLLI-------NRNGE--------L 140
Query: 190 KLGDFGLAKSLQASIEFATTYVGTPYYMSPEVL-RDQPYSPLSDIWSLGCILYELCSLHV 248
KL DFGLA++ + + V T +Y P+VL + YS D+WS GCI EL +
Sbjct: 141 KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR 200
Query: 249 P 249
P
Sbjct: 201 P 201
>Hs16418343 [T] KOG0583 Serine/threonine protein kinase
Length = 268
Score = 83.6 bits (205), Expect = 5e-16
Identities = 75/289 (25%), Positives = 123/289 (41%), Gaps = 46/289 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVV-READNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDN 68
Y+L + IG G++ V++ ++ KV ++ + G ++ L E I+ L H N
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQIVRTLDHKN 69
Query: 69 IVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFK 128
I++ + A + L ME GD+ + +PE + Q++ A+
Sbjct: 70 IIQVYEMLESADGK-ICLVMELAEGGDVFDCVL----NGGPLPESRAKALFRQMVEAIRY 124
Query: 129 CHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVI 188
CH G V HRDLK N L G++
Sbjct: 125 CH----------------------GCGVAHRDLKCENALLQGFN---------------- 146
Query: 189 IKLGDFGLAKSLQASI-EFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSL 246
+KL DFG AK L S E + T+ G+ Y +PEVL+ P+ S D+WS+G +LY +
Sbjct: 147 LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCA 206
Query: 247 HVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPS 295
+PF ++ + + G P S + QD++ R ++ D RPS
Sbjct: 207 SLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQDLLKRLLEPDMILRPS 255
>Hs15277312 [R] KOG0584 Serine/threonine protein kinase
Length = 1231
Score = 83.6 bits (205), Expect = 5e-16
Identities = 78/293 (26%), Positives = 134/293 (45%), Gaps = 51/293 (17%)
Query: 15 EIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVEFF- 73
EIGRGSF +V + + + E++ ++ ERQ+ E +L L+H NIV F+
Sbjct: 167 EIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYD 226
Query: 74 HWDHDAKSNT-LFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYG 132
W + + L E + G L +R ++ + V + R QIL L H+
Sbjct: 227 SWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRV----LQRWSRQILRGL---HF- 278
Query: 133 RDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLG 192
L S+ ++HRDLK N+F+TG +K+G
Sbjct: 279 ----------------LHSRVPPILHRDLKCDNVFITGPTGS--------------VKIG 308
Query: 193 DFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPF-Q 251
D GLA +AS FA + +GTP +M+PE + ++ Y D+++ G + E+ + P+ +
Sbjct: 309 DLGLATLKRAS--FAKSVIGTPEFMAPE-MYEEKYDEAVDVYAFGMCMLEMATSEYPYSE 365
Query: 252 AKTYTELQGKVKAGYFEPLPHFYSK----NLQDIITRCIQVDFTKRPSTWSLL 300
+ ++ KV +G P+ + K +++II CI+ D +R + LL
Sbjct: 366 CQNAAQIYRKVTSG---RKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLL 415
>At5g35410 [T] KOG0583 Serine/threonine protein kinase
Length = 446
Score = 83.6 bits (205), Expect = 5e-16
Identities = 84/308 (27%), Positives = 132/308 (42%), Gaps = 57/308 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQ--QLISECAILSQLKHD 67
Y + IG G+F V K R D V ++ K R Q+ E +I+ ++H
Sbjct: 11 YEVGRTIGEGTFAKV-KFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHP 69
Query: 68 NIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALF 127
NIV + + A + +++ +E+ + G+L I + + +Y Q++ A+
Sbjct: 70 NIVRLY--EVLASPSKIYIVLEFVTGGELFDRIVHKGRLEESESRKY----FQQLVDAVA 123
Query: 128 KCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKV 187
CH KG V HRDLKP N+ L + N N
Sbjct: 124 HCH--------------------CKG--VYHRDLKPENLLL-----DTNGN--------- 147
Query: 188 IIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSL 246
+K+ DFGL+ Q +E T GTP Y++PEVL Q Y +DIWS G IL+ + +
Sbjct: 148 -LKVSDFGLSALPQEGVELLRTTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAG 206
Query: 247 HVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRC--------IQVDFTKRPSTWS 298
++PF L K+ A F P ++S ++ +I R IQ+ K+ W
Sbjct: 207 YLPFSETDLPGLYRKINAAEFS-CPPWFSAEVKFLIHRILDPNPKTRIQIQGIKK-DPWF 264
Query: 299 LLNDIQCR 306
LN + R
Sbjct: 265 RLNYVPIR 272
>At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 488
Score = 83.6 bits (205), Expect = 5e-16
Identities = 77/295 (26%), Positives = 129/295 (43%), Gaps = 59/295 (20%)
Query: 17 GRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLIS-ECAILSQLKHDNIVEFFHW 75
G GS+ V + ++ V K + + + + + E +L QL+H I++ +
Sbjct: 48 GVGSYSKVVRAKKKETGTVYALKIMDKKFITKENKTAYVKLERIVLDQLEHPGIIKLYFT 107
Query: 76 DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHYGRDL 135
D S L++ +E C G+L I K D
Sbjct: 108 FQDTSS--LYMALESCEGGELFDQITR-------------------------KGRLSEDE 140
Query: 136 SKLQT--IYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKLGD 193
++ T + DA+E + S G +IHRD+KP N+ LT S IK+ D
Sbjct: 141 ARFYTAEVVDALEY-IHSMG--LIHRDIKPENLLLT---------------SDGHIKIAD 182
Query: 194 FGLAKSLQ----------ASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYEL 243
FG K +Q AS + A T+VGT Y+ PEVL P + +D+W+LGC LY++
Sbjct: 183 FGSVKPMQDSQITVLPNAASDDKACTFVGTAAYVPPEVLNSSPATFGNDLWALGCTLYQM 242
Query: 244 CSLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWS 298
S PF+ + + ++ A + P+ +S+ +D+I R + + ++RP S
Sbjct: 243 LSGTSPFKDASEWLIFQRIIARDIK-FPNHFSEAARDLIDRLLDTEPSRRPGAGS 296
>7296450 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 769
Score = 83.6 bits (205), Expect = 5e-16
Identities = 70/283 (24%), Positives = 123/283 (42%), Gaps = 52/283 (18%)
Query: 10 YRLLEEIGRGSFGSVRKVV-----READNKVMVRKEVRYGHMNAKERQQLISECAILSQL 64
Y + +G+G F +V K ++ K++ +K ++ + + RQ E I S+L
Sbjct: 14 YEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQ----EVEIHSRL 69
Query: 65 KHDNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILM 124
KH ++++ + + DA N ++L +E G+L RY H + E I+ Q++
Sbjct: 70 KHPSVLQLYTFFQDA--NYVYLVLELAHNGELH---RYMNHIARPFTETEAASILKQVVA 124
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
L H + ++HRD+ N+ L+
Sbjct: 125 GLLYLH----------------------SHNIMHRDISLSNLLLS--------------- 147
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELC 244
++ +K+ DFGLA L+ E T GTP Y+SPEV+ + +D+WS+GC+LY L
Sbjct: 148 REMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLL 207
Query: 245 SLHVPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQ 287
PF+ KV + +P S QD+I + ++
Sbjct: 208 VGRPPFETDAVQSTLNKVVMSEY-IMPAHLSYEAQDLINKLLK 249
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 83.6 bits (205), Expect = 5e-16
Identities = 70/301 (23%), Positives = 127/301 (41%), Gaps = 56/301 (18%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLIS----ECAILSQLKHDNI 69
++IG G+F S + +M K+V Y + E+++++ E ++S L H NI
Sbjct: 24 QQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNI 83
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ + + LF+ E+ + G ++ ++ Y ++ V Y Q+L L
Sbjct: 84 IRMLGATCEKSNYNLFI--EWMAGGSVAHLLSKYGAFKESVVINYT----EQLLRGLSYL 137
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H + +IHRD+K N+ +D + +
Sbjct: 138 HENQ----------------------IIHRDVKGANLL--------------IDSTGQRL 161
Query: 190 KLGDFGLAKSLQA----SIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCS 245
++ DFG A L + + EF +GT +M+PEVLR Q Y D+WS+GC + E+
Sbjct: 162 RIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMAC 221
Query: 246 LHVPFQAKTYTELQGKV------KAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSL 299
P+ A+ ++ + A +P S L+D+ RC+++ RP + L
Sbjct: 222 AKPPWNAEKHSNHLALIFKVIIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSREL 281
Query: 300 L 300
L
Sbjct: 282 L 282
>YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 447
Score = 83.2 bits (204), Expect = 6e-16
Identities = 78/297 (26%), Positives = 131/297 (43%), Gaps = 53/297 (17%)
Query: 16 IGRGSFGSVRKVVREADN-----KVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIV 70
+G GSFG VR+ + + N K++++K ++ ++ + Q L E +IL +L H NIV
Sbjct: 53 LGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNV---QLQMLYEELSILQKLSHPNIV 109
Query: 71 EFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCH 130
F W + ++ + + G+L I R E I+VQIL A+
Sbjct: 110 SFKDWFES--KDKFYIVTQLATGGELFDRIL----SRGKFTEVDAVEIIVQILGAV---- 159
Query: 131 YGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIK 190
E + SK V+HRDLKP N+ Y D+ + +
Sbjct: 160 ----------------EYMHSKN--VVHRDLKPENVL---YVDKSENSP---------LV 189
Query: 191 LGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPF 250
+ DFG+AK L+ + G+ Y++PEVL + DIWS+G I Y L + PF
Sbjct: 190 IADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPF 249
Query: 251 QAKTYTELQGKVKAGYFEPLPHF-----YSKNLQDIITRCIQVDFTKRPSTWSLLND 302
A++ + A + H S +++ I + ++++ RP+ LL+D
Sbjct: 250 IAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDD 306
>YBR160w [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 298
Score = 83.2 bits (204), Expect = 6e-16
Identities = 69/242 (28%), Positives = 114/242 (46%), Gaps = 48/242 (19%)
Query: 10 YRLLEEIGRGSFGSVRKVVR---EADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKH 66
Y+ LE++G G++G V K + +V+ K++R + I E ++L +LK
Sbjct: 8 YKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKD 67
Query: 67 DNIVEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVP--EEYVWRIMVQILM 124
DNIV + H + ++ L+L E+ DL + RY + K P + V + M+Q+
Sbjct: 68 DNIVRLYDIVH-SDAHKLYLVFEFL---DLD-LKRYMEGIPKDQPLGADIVKKFMMQLCK 122
Query: 125 ALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDY 184
+ CH R ++HRDLKP N+ + N++ +
Sbjct: 123 GIAYCHSHR----------------------ILHRDLKPQNLLI-------NKDGN---- 149
Query: 185 SKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEV-LRDQPYSPLSDIWSLGCILYEL 243
+KLGDFGLA++ + T + T +Y +PEV L + YS D WS+GCI E+
Sbjct: 150 ----LKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEM 205
Query: 244 CS 245
C+
Sbjct: 206 CN 207
>SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 340
Score = 83.2 bits (204), Expect = 6e-16
Identities = 81/294 (27%), Positives = 132/294 (44%), Gaps = 53/294 (18%)
Query: 12 LLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNIVE 71
++ +G G+ G+V V N M RK V G ++K ++Q++ E +L + IV
Sbjct: 68 VVRHLGEGNGGAVSLVKHR--NIFMARKTVYVGS-DSKLQKQILRELGVLHHCRSPYIVG 124
Query: 72 FFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCHY 131
F+ N + L MEY G L ++R + +P + + +I+ ++ L
Sbjct: 125 FY--GAFQYKNNISLCMEYMDCGSLDAILR----EGGPIPLDILGKIINSMVKGLIY--- 175
Query: 132 GRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIKL 191
+Y+ + +IHRDLKP N+ + S+ IKL
Sbjct: 176 ---------LYNVLH---------IIHRDLKPSNVVVN---------------SRGEIKL 202
Query: 192 GDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPFQ 251
DFG++ L S+ A T+VGT YMSPE +R Y+ SDIWSLG + EL + +P+
Sbjct: 203 CDFGVSGELVNSV--AQTFVGTSTYMSPERIRGGKYTVKSDIWSLGISIIELATQELPWS 260
Query: 252 AKTYTELQGKVKAGYF----EP--LPHFYSKNLQDIITRCIQVDFTKRPSTWSL 299
+ G + + EP LP + ++L+ + C+ D T R S L
Sbjct: 261 FSNIDDSIGILDLLHCIVQEEPPRLPSSFPEDLRLFVDACLHKDPTLRASPQQL 314
>Hs7661974 [T] KOG0583 Serine/threonine protein kinase
Length = 651
Score = 83.2 bits (204), Expect = 6e-16
Identities = 78/294 (26%), Positives = 132/294 (44%), Gaps = 47/294 (15%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
Y L E IG G F V+ + MV ++ + + ++ +E L L+H +I
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGE-MVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHI 69
Query: 70 VEFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKC 129
+ +H A N +F+ +EYC G+L Y + + EE + QI+ A+
Sbjct: 70 CQLYHVLETA--NKIFMVLEYCPGGELFD----YIISQDRLSEEETRVVFRQIVSAVAYV 123
Query: 130 HYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVII 189
H S+GY HRDLKP N+ DE+++ +
Sbjct: 124 H--------------------SQGYA--HRDLKPENLLF----DEYHK-----------L 146
Query: 190 KLGDFGLAKSLQASIEF-ATTYVGTPYYMSPEVLRDQPY-SPLSDIWSLGCILYELCSLH 247
KL DFGL + + ++ T G+ Y +PE+++ + Y +D+WS+G +LY L
Sbjct: 147 KLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGF 206
Query: 248 VPFQAKTYTELQGKVKAGYFEPLPHFYSKNLQDIITRCIQVDFTKRPSTWSLLN 301
+PF L K+ G ++ +P + S + ++ + +QVD KR S +LLN
Sbjct: 207 LPFDDDNVMALYKKIMRGKYD-VPKWLSPSSILLLQQMLQVDPKKRISMKNLLN 259
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 83.2 bits (204), Expect = 6e-16
Identities = 63/252 (25%), Positives = 108/252 (42%), Gaps = 54/252 (21%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ L+E +G G++G V K K ++ ++N E ++ E +L + H
Sbjct: 21 FELIEVVGNGTYGQVYK---GRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRN 77
Query: 70 VEFFHW-------DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
V ++ K + L+L ME+C G ++ +++ K + EE++ I +I
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGS--LKEEWIAYICREI 135
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
L L+ H + VIHRD+K N+ LT +
Sbjct: 136 LRGLYHLHQSK----------------------VIHRDIKGQNVLLTDSAE--------- 164
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-----DQPYSPLSDIWSLG 237
+KL DFG++ L ++ T++GTPY+M+PEV+ + Y SD+WSLG
Sbjct: 165 ------VKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLG 218
Query: 238 CILYELCSLHVP 249
E+ H P
Sbjct: 219 ITALEMAEGHPP 230
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 83.2 bits (204), Expect = 6e-16
Identities = 63/252 (25%), Positives = 108/252 (42%), Gaps = 54/252 (21%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ L+E +G G++G V K K ++ ++N E ++ E +L + H
Sbjct: 21 FELIEVVGNGTYGQVYK---GRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRN 77
Query: 70 VEFFHW-------DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
V ++ K + L+L ME+C G ++ +++ K + EE++ I +I
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGS--LKEEWIAYICREI 135
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
L L+ H + VIHRD+K N+ LT +
Sbjct: 136 LRGLYHLHQSK----------------------VIHRDIKGQNVLLTDSAE--------- 164
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-----DQPYSPLSDIWSLG 237
+KL DFG++ L ++ T++GTPY+M+PEV+ + Y SD+WSLG
Sbjct: 165 ------VKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLG 218
Query: 238 CILYELCSLHVP 249
E+ H P
Sbjct: 219 ITALEMAEGHPP 230
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 83.2 bits (204), Expect = 6e-16
Identities = 63/252 (25%), Positives = 108/252 (42%), Gaps = 54/252 (21%)
Query: 10 YRLLEEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQLISECAILSQLKHDNI 69
+ L+E +G G++G V K K ++ ++N E ++ E +L + H
Sbjct: 21 FELIEVVGNGTYGQVYK---GRHVKTAQLAAIKIMNINEDEEDEIKLEINMLKKHSHHRN 77
Query: 70 VEFFHW-------DHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQI 122
V ++ K + L+L ME+C G ++ +++ K + EE++ I +I
Sbjct: 78 VATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGS--LKEEWIAYICREI 135
Query: 123 LMALFKCHYGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDV 182
L L+ H + VIHRD+K N+ LT +
Sbjct: 136 LRGLYHLHQSK----------------------VIHRDIKGQNVLLTDSAE--------- 164
Query: 183 DYSKVIIKLGDFGLAKSLQASIEFATTYVGTPYYMSPEVLR-----DQPYSPLSDIWSLG 237
+KL DFG++ L ++ T++GTPY+M+PEV+ + Y SD+WSLG
Sbjct: 165 ------VKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLG 218
Query: 238 CILYELCSLHVP 249
E+ H P
Sbjct: 219 ITALEMAEGHPP 230
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 83.2 bits (204), Expect = 6e-16
Identities = 75/285 (26%), Positives = 120/285 (41%), Gaps = 54/285 (18%)
Query: 14 EEIGRGSFGSVRKVVREADNKVMVRKEVRYGHMNAKERQQ---LISECAILSQLKHDNIV 70
++IG GS G V EA K+ ++ V MN +++Q+ L +E +IL Q +H NIV
Sbjct: 253 KQIGEGSTGVV-----EAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIV 307
Query: 71 EFFHWDHDAKSNTLFLYMEYCSKGDLSQMIRYYKHQRKYVPEEYVWRIMVQILMALFKCH 130
FF + L++ ME+ G L+ ++ + + E + I Q+L AL H
Sbjct: 308 RFF--SSHLVDDELWVVMEFMEGGSLTDIVTATR-----MTEPQIATISRQVLGALDFLH 360
Query: 131 YGRDLSKLQTIYDAMEEPLKSKGYVVIHRDLKPGNIFLTGYDDEFNQNASDVDYSKVIIK 190
+ VIHRD+K +I L +K
Sbjct: 361 ARK----------------------VIHRDIKSDSILLK---------------RDGTVK 383
Query: 191 LGDFGLAKSLQASIEFATTYVGTPYYMSPEVLRDQPYSPLSDIWSLGCILYELCSLHVPF 250
L DFG L + + VGTPY+ + EV+ +PY +DIWS G +L E+ PF
Sbjct: 384 LTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPF 443
Query: 251 QAKTYTELQGKVKAGYFEPLPHF--YSKNLQDIITRCIQVDFTKR 293
+ +++ + S L ++++ CI D KR
Sbjct: 444 FNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKR 488
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,751,918
Number of Sequences: 60738
Number of extensions: 1081489
Number of successful extensions: 8357
Number of sequences better than 1.0e-05: 1395
Number of HSP's better than 0.0 without gapping: 199
Number of HSP's successfully gapped in prelim test: 1196
Number of HSP's that attempted gapping in prelim test: 5127
Number of HSP's gapped (non-prelim): 1725
length of query: 394
length of database: 30,389,216
effective HSP length: 108
effective length of query: 286
effective length of database: 23,829,512
effective search space: 6815240432
effective search space used: 6815240432
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)