ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1509 good U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1509 531707 530172 -512
(512 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YMR004w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 495 e-140
Hs20540054 [U] KOG2273 Membrane coat complex Retromer subunit VP... 113 6e-25
SPAC3A11.06 [U] KOG2273 Membrane coat complex Retromer subunit V... 101 2e-21
YJL036w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 66 1e-10
Hs4507145 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 64 5e-10
Hs16418371 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related pro... 64 7e-10
Hs22045020 [U] KOG2273 Membrane coat complex Retromer subunit VP... 59 2e-08
CE19073 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins 58 3e-08
At5g06140 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 57 5e-08
CE07927 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 55 3e-07
7299654 [U] KOG2527 Sorting nexin SNX11 54 7e-07
7294889 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins 54 7e-07
SPCPJ732.01 [U] KOG2273 Membrane coat complex Retromer subunit V... 53 1e-06
Hs7706715 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 52 2e-06
7295807 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 51 4e-06
Hs4507143 [U] KOG2527 Sorting nexin SNX11 50 6e-06
Hs20070247_1 [ZUD] KOG2101 Intermediate filament-like protein so... 50 8e-06
>YMR004w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 511
Score = 495 bits (1274), Expect = e-140
Identities = 239/448 (53%), Positives = 326/448 (72%), Gaps = 13/448 (2%)
Query: 77 NDVL----WD--RPNIGST--TQETDIRG----VNRFQATDTPQYAANDEYKNWVESVRK 124
NDVL WD R +G+T +Q +I +++ A D + + +W +VRK
Sbjct: 63 NDVLEESIWDDSRNPLGATGMSQTPNIAANETVIDKNDARDQNIEESEADLLDWTNNVRK 122
Query: 125 TYFPLAEDIVSVEEIPEREGLVFKHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDV 184
TY PL DI+ +EEIPEREGL+FKH NYLVKHL LP+T PS++RTVVRRYSDF WL+++
Sbjct: 123 TYRPLDADIIIIEEIPEREGLLFKHANYLVKHLIALPSTSPSEERTVVRRYSDFLWLREI 182
Query: 185 LLRKYPFRMVPELPPKKIGSQNADPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLTV 244
LL++YPFRM+PELPPK+IGSQNAD LFL KRR GLSRFINLVMKHP L +DDLVLTFLTV
Sbjct: 183 LLKRYPFRMIPELPPKRIGSQNADQLFLKKRRIGLSRFINLVMKHPKLSNDDLVLTFLTV 242
Query: 245 PTDLSGWRKQAHYDTTDEFTDKHISSSFMNLWRKEFSEQWNKADERIDIALDTWVKVTVL 304
TDL+ WRKQA YDT++EF DK IS FM +W+KEF+EQWN+A ID +++ W ++T+L
Sbjct: 243 RTDLTSWRKQATYDTSNEFADKKISQEFMKMWKKEFAEQWNQAASCIDTSMELWYRITLL 302
Query: 305 IERYEKRMKQVAHERKLLGQILNAIPDTTEALYP-QSTATVSQINEGVGLIVEHLNSCAD 363
+ER+EKR+ Q+ HER +++ + T LYP Q T+ IN + +I +HL + +
Sbjct: 303 LERHEKRIMQMVHERNFFETLVDNFSEVTPKLYPVQQNDTILDINNNLSIIKKHLETTSS 362
Query: 364 VIERENEEVDSGLSVRFKAFIDVIIALKGLFERYKMMAGNNIPQLQRRVEINQERLNTLE 423
+ ++E EE+ LS +FK F D++++L+ LFERYK+MA NN+ +LQR VE+N+E+L +++
Sbjct: 363 ICKQETEEISGTLSPKFKIFTDILLSLRSLFERYKIMAANNVVELQRHVELNKEKLESMK 422
Query: 424 SNPDVKGAEYDRVKQSISRDKRSILDQMNRSWLIRECILEEFTIFHETQFLITDCFQRWI 483
PDV GAEYDR+K+ I +D+RSI++Q NR+WLIR+CILEEFTIF ETQFLIT FQ W
Sbjct: 423 GKPDVSGAEYDRIKKIIQKDRRSIIEQSNRAWLIRQCILEEFTIFQETQFLITRAFQDWA 482
Query: 484 EINLRYTNNNVDNWEKICKKLRDMPLQR 511
++N + ++ WEK+ + DMP+ R
Sbjct: 483 KLNSNHAGLKLNEWEKLVTSIMDMPISR 510
>Hs20540054 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 465
Score = 113 bits (283), Expect = 6e-25
Identities = 97/384 (25%), Positives = 182/384 (47%), Gaps = 23/384 (5%)
Query: 129 LAEDIVSVEEIPEREGLVFKHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRK 188
LA D V VE IPE++GL KH Y V + +V RRY+DF Q++LL K
Sbjct: 72 LARDTVQVELIPEKKGLFLKHVEYEV--------SSQRFKSSVYRRYNDFVVFQEMLLHK 123
Query: 189 YPFRMVPELPPKKIGSQNADPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLTVP-TD 247
+P+RMVP LPPK++ AD F+ RR+ L RF+NLV +HP+ D ++ FL+ +D
Sbjct: 124 FPYRMVPALPPKRM--LGADREFIEARRRALKRFVNLVARHPLFSEDVVLKLFLSFSGSD 181
Query: 248 LSGWRKQAHYDTTDEFTDKHISSSFMNLWRKEFSEQWNKADERIDIALDTWVKVTVLIER 307
+ K++ DEF + +++ + + Q+ + E I +++ K+ ER
Sbjct: 182 VQNKLKESAQCVGDEFLNCKLATRAKDFLPADIQAQFAISRELIRNIYNSFHKLRDRAER 241
Query: 308 YEKRMKQVAHERKLLGQILNAI-PDTT-----EALYPQSTATVSQINEGVGLIVEHLNSC 361
R A + + G+ L+AI DTT AL + ++ Q +G+ + L
Sbjct: 242 IASRAIDNAADLLIFGKELSAIGSDTTPLPSWAALNSSTWGSLKQALKGLSVEFALL--- 298
Query: 362 ADVIERENEEVDSGLSVRFKAFIDVIIALKGLFERY-KMMAGNNIPQLQRRVEINQERLN 420
AD ++ ++ ++ + + F+D++ + K L ER+ K + + L + + ++ ++
Sbjct: 299 ADKAAQQGKQEENDVVEKLNLFLDLLQSYKDLCERHEKGVLHKHQRALHKYSLMKRQMMS 358
Query: 421 TLESNPDVKGAEYDRVKQSISRDKRSILDQMNRSWLIRECILEEFTIFHETQFLITDCFQ 480
N + + E +++ I + +I R++ C+ +E + H L + +
Sbjct: 359 ATAQNREPESVE--QLESRIVEQENAIQTMELRNYFSLYCLHQETQLIHVYLPLTSHILR 416
Query: 481 RWIEINLRYTNNNVDNWEKICKKL 504
++ ++ W + KL
Sbjct: 417 AFVNSQIQGHKEMSKVWNDLRPKL 440
>SPAC3A11.06 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 664
Score = 101 bits (252), Expect = 2e-21
Identities = 87/414 (21%), Positives = 177/414 (42%), Gaps = 24/414 (5%)
Query: 99 NRFQATDTPQYAANDEYKNWVESVRKTYFPLAEDIVSVEEIPEREGLVFKHTNYLVKHLT 158
NR + P +N + ++ + T FP + ++ ++ ++H NY++
Sbjct: 254 NRLSPSTQP-LLSNSRHSSFRLASSSTSFPASLEMNVDIDLEPSGYFFYRHNNYII---- 308
Query: 159 PLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNAD-PLFLAKRRK 217
+D S+ R V+RRYSDF WL L++KYPFR VP +P KK S+ + F
Sbjct: 309 ----SDSSNTREVLRRYSDFFWLHSYLMKKYPFRRVPLIPLKKFHSKCFNSKQFFRTPPP 364
Query: 218 GLSRFINLVMKHPVLRSDDLVLTFLTVPTDLSGWRKQAHYDTTDEFTD-KHISSSFMNLW 276
GLS F+N + HP+ +D++V F T P WR++ E + S +
Sbjct: 365 GLSDFVNDLSHHPIFSNDEVVRVFFTEPNVFKNWRRENQKRIDQEIEQFLVVPQSQVPDA 424
Query: 277 RKEFSEQWNKADERIDIALDTWVKVTVLIERYEKRMKQVAHERKLLGQILNAIPDTTEAL 336
+ E+ K + A++ + + + E+ ++ + L N + D+ L
Sbjct: 425 SETVKERLLKLNMSTTTAINNQLNIFRIFEKMIFTLQHFHEDFLRLQNSFNCLLDS--GL 482
Query: 337 YPQSTATVSQINEG--VGLIVEHLNSCADVIERENEEVDSGLSVRFKAFIDVIIALKGLF 394
Y Q + NE + + H + ++ ++N+ V + I ++I+L+ L
Sbjct: 483 YHQVFTSTFAQNESKIMSMASGHFYNIDSLLHQQNDAVKHTFLLGLSKEIKILISLRLLI 542
Query: 395 ERYKMMAGNNIPQLQRRVEINQERLNTLESNPDVKG--------AEYDRVKQSISRDKRS 446
ER + ++ +++ + N E L +N D G + R + S+ K
Sbjct: 543 ERISEVFSTDLTKVRHTIS-NDENLLRETANSDESGRNRTFLNRSSKKRAENSLKSKKEL 601
Query: 447 ILDQMNRSWLIRECILEEFTIFHETQFLITDCFQRWIEINLRYTNNNVDNWEKI 500
L +N+ + I + +E + + F + + + + + +++ ++ W +
Sbjct: 602 YLKNLNQRYQIAHELEQELSYLQDYVFSLGNPYVEYCKQHVKLEEESLKIWHTL 655
>YJL036w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 423
Score = 65.9 bits (159), Expect = 1e-10
Identities = 57/197 (28%), Positives = 84/197 (41%), Gaps = 15/197 (7%)
Query: 164 DPSDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPPKK----IGSQNADPLFLAKRRKGL 219
DP V RRYSD L D+LL ++P ++P LP KK I F KR L
Sbjct: 68 DPESIIVVHRRYSDLLLLHDILLNRFPTCIIPPLPDKKVFQYIAGDRFSQRFTQKRCHSL 127
Query: 220 SRFINLVMKHPVLRSDDLVLTFLTVPTDLSGWRK---QAHYDTTDEFTDKHISSSFMNLW 276
F+ V HP L + TFL V D RK + DE TD +FMN +
Sbjct: 128 QNFLRRVSLHPDLSQSKVFKTFL-VSKDWESHRKVLQDSLQPNKDEVTD-----AFMNAF 181
Query: 277 R--KEFSEQWNKADERIDIALDTWVKVTVLIERYEKRMKQVAHERKLLGQILNAIPDTTE 334
+ + +E++ + E+ D T K+ L + K+ ++ + LG L + +
Sbjct: 182 KTVHKQNEEFTEIREKSDKLDRTVTKIDKLFHKVVKKNDSMSEDYTKLGSNLQELQELVT 241
Query: 335 ALYPQSTATVSQINEGV 351
+ A + NEGV
Sbjct: 242 GENEELAAKLKIFNEGV 258
>Hs4507145 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 450
Score = 63.9 bits (154), Expect = 5e-10
Identities = 47/144 (32%), Positives = 74/144 (50%), Gaps = 15/144 (10%)
Query: 114 EYKNWVESVRKTYFPLAEDIVSVEEIPEREG-----LVFKHTNYLVKHLTPLPNTDPSDD 168
E + V+++ F L + +SV E +R G + +T YL++ + + +TD
Sbjct: 40 EESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRS-VEHTDGQSV 98
Query: 169 RT--VVRRYSDFDWLQDVLLRKYPFRMVPELPPK-------KIGSQNADPLFLAKRRKGL 219
T + RRYS+F+ L+ LL YP +VP LP K K+ + N DP F+ +RR GL
Sbjct: 99 LTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGL 158
Query: 220 SRFINLVMKHPVLRSDDLVLTFLT 243
F+ + HP+L D + FLT
Sbjct: 159 ENFLLRIASHPILCRDKIFYLFLT 182
>Hs16418371 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 628
Score = 63.5 bits (153), Expect = 7e-10
Identities = 38/94 (40%), Positives = 50/94 (52%), Gaps = 3/94 (3%)
Query: 171 VVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNADPLFLAKRRKGLSRFINLVMKHP 230
V RRY FDWL L K+P VP LP K+ + + F++KRRKGL ++N + HP
Sbjct: 309 VHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEED-FISKRRKGLIWWMNHMASHP 367
Query: 231 VLRSDDLVLTFLTVP--TDLSGWRKQAHYDTTDE 262
VL D+ FLT P TD W++ DE
Sbjct: 368 VLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDE 401
>Hs22045020 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 333
Score = 58.5 bits (140), Expect = 2e-08
Identities = 69/297 (23%), Positives = 129/297 (43%), Gaps = 37/297 (12%)
Query: 170 TVVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNADPL---FLAKRRKGLSRFINLV 226
+V RRY DFDWL+ L P ++P LP K + D F+ RRK L +F+ +
Sbjct: 24 SVRRRYQDFDWLRSKLEESQPTHLIPPLPEKFVVKGVVDRFSEEFVETRRKALDKFLKRI 83
Query: 227 MKHPVLRSDDLVLTFLTVPTDLSGWRKQA-HYDTTDEFTDKHISSSFMNLWRK-EFSEQW 284
HPVL ++ FLT DL+ ++KQ T + KH++ + R EF+
Sbjct: 84 TDHPVLSFNEHFNIFLTA-KDLNAYKKQGIALLTRMGESVKHVTGGYKLRTRPLEFA--- 139
Query: 285 NKADERIDIALDTWVKVTVLIERYEKRMKQVAHERKLLGQILNAIPDTTEALYPQSTATV 344
I LDT+ I+R +R+ + E + L ++ P +Y +A
Sbjct: 140 -----AIGDYLDTFALKLGTIDRIAQRI--IKEEIEYLVELREYGP-----VYSTWSALE 187
Query: 345 SQINEGVGLIVEHLNSCADVIERENEEVDSGLSVRFKAFIDVIIALKGLFERYKMMAG-- 402
++ E + + + +C+ +E +++ + +I ++K + ++ +
Sbjct: 188 GELAEPLEGVSACIGNCSTALEELTDDMTEDFLPVLREYILYSDSMKSVLKKRDQVQAEY 247
Query: 403 -----------NNIPQLQRRVEINQERLNTLESNPDVKGAEYDRVKQSISRDKRSIL 448
+ P++ VE Q+R+ N D+K A+ +R + + +D R +L
Sbjct: 248 EAKLEAVALRKEDRPKVPADVEKCQDRMECF--NADLK-ADMERWQNNKRQDFRQLL 301
>CE19073 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 361
Score = 58.2 bits (139), Expect = 3e-08
Identities = 38/147 (25%), Positives = 72/147 (48%), Gaps = 9/147 (6%)
Query: 128 PLAEDIVSVEEIPEREGLVFKHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLR 187
P+ + + + P++E + +++ +T ++ + R V RRY FDWL + L
Sbjct: 10 PIQQYYTCIVDKPKKESKLKGLKSFIAYSIT---SSLTNIQRQVSRRYKHFDWLHEQLSA 66
Query: 188 KYPFRMVPELPPKKIGSQNADPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLTVPTD 247
KY +P LP K++ + + L + R+ L ++N + +HPVL ++ L F++ TD
Sbjct: 67 KYVLIPIPPLPEKQVAGRYEEDL-IDHRKHILQLWVNKICRHPVLSQSEVWLHFISC-TD 124
Query: 248 LSGWRKQAHYDTTDEFTDKHISSSFMN 274
W+ DE+ I +F+N
Sbjct: 125 EKDWKNGKRRAEKDEY----IGGAFLN 147
>At5g06140 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 402
Score = 57.4 bits (137), Expect = 5e-08
Identities = 43/131 (32%), Positives = 60/131 (44%), Gaps = 13/131 (9%)
Query: 134 VSVEEIPEREGLVFKHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPFRM 193
VSV + + V + +Y V T LP ++ V+RRYSDF WL+D L KY
Sbjct: 28 VSVTDPVKLGNGVQAYISYRVITKTNLPEYQ-GPEKIVIRRYSDFVWLRDRLFEKYKGIF 86
Query: 194 VPELPPKK-IGSQNADPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLTVPTDLSGWR 252
+P LP K + F+ RR L F+N + HP L+ + + TFL
Sbjct: 87 IPPLPEKSAVEKFRFSAEFIEMRRAALDIFVNRIALHPELQQSEDLRTFL---------- 136
Query: 253 KQAHYDTTDEF 263
QA +T D F
Sbjct: 137 -QADEETMDRF 146
>CE07927 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 472
Score = 55.1 bits (131), Expect = 3e-07
Identities = 67/314 (21%), Positives = 138/314 (43%), Gaps = 32/314 (10%)
Query: 173 RRYSDFDWLQDVLLRKYPFR--MVPELPPKKIGS-----QNADPLFLAK----RRKGLSR 221
RR+SDF L ++ KY + ++P+ P K I + N+DP + R + L R
Sbjct: 131 RRFSDFLGLHGKIVEKYLAKGIVIPQPPEKSISALTKTKTNSDPAMSREVGIQRARQLER 190
Query: 222 FINLVMKHPVLRSDDLVLTFLTVPTDLSGWRKQAHYDTTDEFTDKHISSSFMNLWRK--- 278
+I +++HP +R+D V FLT+ +DL K F K I +F ++ K
Sbjct: 191 YICRLIQHPRMRNDCDVRDFLTIESDLP---KAVQTAALSSFGVKKIFKNFQVVFSKMAF 247
Query: 279 --EFSEQW-NKADERIDIALDTWVKVTVLIERYEKRMKQVAHERKLLGQILNAIPDTTEA 335
E ++W + ++D + K+ + E + +A + LG+ L+ + E+
Sbjct: 248 HMEEGDRWFEQVQSQVDELDEALRKLYTVTETLVASRRDMATSGEQLGKALSMLAACEES 307
Query: 336 LYPQSTATVSQINEGVGLIVEHLNSCADVIERENEEVDSGLSVRFKAFIDVIIALKGLFE 395
+ ++ + + + + + V ++ E +S S +I +I ALK +F
Sbjct: 308 ---------TSLSRALSSLTDVTENVSAVYGKQAEVDNSKFSESIYEYIMLISALKDVFG 358
Query: 396 RYKMMAGNNIPQLQRRVEINQERLNTLESNPDVKGAEYDRVKQSISRDKRSILDQMNRSW 455
++ A Q+ + +++ ++ + + D++K I D +DQ+ + +
Sbjct: 359 E-RVRAWQQWQDAQQTLARKRDQKTKIDLSAGGRNERSDQLKGEI-EDTVQKMDQLEQHF 416
Query: 456 L-IRECILEEFTIF 468
+ + + I EE F
Sbjct: 417 IELSKAIREEVARF 430
>7299654 [U] KOG2527 Sorting nexin SNX11
Length = 167
Score = 53.5 bits (127), Expect = 7e-07
Identities = 37/103 (35%), Positives = 55/103 (52%), Gaps = 10/103 (9%)
Query: 148 KHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNA 207
++T+Y V+ T LP + +V RRYSDF+WL++ L R +VP LP K Q
Sbjct: 50 RYTDYEVRMRTNLPVFKVKES-SVRRRYSDFEWLRNELERDSKI-VVPPLPGKAWKRQMP 107
Query: 208 --------DPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFL 242
D F+ +RRKGL FIN + HP+ +++ + FL
Sbjct: 108 FRGDEGIFDESFIEERRKGLEAFINKIAGHPLAQNERCLHMFL 150
>7294889 [U] KOG2528 Sorting nexin SNX9/SH3PX1 and related proteins
Length = 531
Score = 53.5 bits (127), Expect = 7e-07
Identities = 35/104 (33%), Positives = 53/104 (50%), Gaps = 6/104 (5%)
Query: 140 PEREGLVFKHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPP 199
P++E ++ LTP N + +V RRY FDWL + L+ K+ VP LP
Sbjct: 192 PKKESKFKGMKTFIAYQLTPSFN-----NISVSRRYKHFDWLHERLVDKFCLIPVPPLPD 246
Query: 200 KKIGSQNADPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLT 243
K+I S + F+ RR L F++ V +HPV+ ++ FLT
Sbjct: 247 KQI-SGRYEEQFVEHRRVQLQEFVDWVCRHPVISKCEVWYHFLT 289
>SPCPJ732.01 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 576
Score = 53.1 bits (126), Expect = 1e-06
Identities = 54/201 (26%), Positives = 85/201 (41%), Gaps = 24/201 (11%)
Query: 149 HTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNAD 208
HT Y V N + TV RRY+DF +L +L +P ++P +P K++ + D
Sbjct: 219 HTVYSVSTRLEEHNQPSVSNVTVQRRYNDFAFLYQLLSNNHPGCIIPPIPEKQVVGR-FD 277
Query: 209 PLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLTVPTDLSGWRKQAHYDTTDEFTDKHI 268
F+ +RR L + + HPVLR D FL T + H T E + +
Sbjct: 278 DEFIEQRRAALEVMLRKISAHPVLRDDYSFKLFLEAETFDP---RMTHRTTLIESSSSPL 334
Query: 269 SS---------SFMNLWRKEFSEQWNKADERIDIALDTWVKVTVLIERYEKRMKQVAHER 319
S SF + + S ++++ D + A DT ++ E ++K V H
Sbjct: 335 RSGPSTSGLLDSFTSAFHTSGSSKFSEQDPILIEAKDT-------LDSLETQLKSVYHAL 387
Query: 320 KL----LGQILNAIPDTTEAL 336
L Q +AI D EA+
Sbjct: 388 LLSIDQRIQFASAIHDFGEAV 408
>Hs7706715 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 387
Score = 52.0 bits (123), Expect = 2e-06
Identities = 33/93 (35%), Positives = 48/93 (51%), Gaps = 4/93 (4%)
Query: 166 SDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGS---QNADPLFLAKRRKGLSRF 222
S + V RRY DF WL+ L +P ++P LP K I + + F+ RRK L +F
Sbjct: 65 SSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIETRRKALHKF 124
Query: 223 INLVMKHPVLRSDDLVLTFLTVPT-DLSGWRKQ 254
+N + HP L ++ FLT +LS +KQ
Sbjct: 125 LNRIADHPTLTFNEDFKIFLTAQAWELSSHKKQ 157
>7295807 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 458
Score = 51.2 bits (121), Expect = 4e-06
Identities = 95/391 (24%), Positives = 157/391 (39%), Gaps = 63/391 (16%)
Query: 152 YLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPF--RMVPELPPK--------K 201
Y V T +P S+ T+ RR+SDF + D+L+ KY R++P P K K
Sbjct: 95 YKVTTKTNIPKFKRSEFSTL-RRFSDFLGIHDLLVGKYMRLGRIIPPAPSKNIIGSTKVK 153
Query: 202 IGSQNADP------LFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFLTVPTDLSGWRKQA 255
I Q ++P ++ RR L RF++ +HPVLR D + FL +L
Sbjct: 154 ISPQQSEPGTPMTQEWVEIRRAALERFVHRTAQHPVLRVDLDFMNFLESDQEL------- 206
Query: 256 HYDTTDEFTDKHISSSFMNLWRKEFSEQWNKADERIDIALDTWV--KVTVL------IER 307
T + + L+ K E NK ++D D W K+T + +++
Sbjct: 207 ---PRSVNTSALSGAGVIRLFNK-VGETVNKITYKMD-ENDPWFDDKITEVESLDANLQK 261
Query: 308 YEKRMKQVAHERKLLGQILNAIPDTTEALYPQSTATVSQINEGVGLIVEHLNSCADVIER 367
MK + R+ L + L +S A +S E GL L++ ADV E+
Sbjct: 262 LHNAMKSLVTSRRELSLL--------TGLVAKSAAMLSTCEEHTGL-SRALSNLADVEEK 312
Query: 368 ----ENEEVDSG---LSVRFKAFIDVIIALKGLF-ERYKMMAGNNIPQLQ---RRVEINQ 416
+E+ +S L+ K ++ + A+K +F ER K Q+Q RR +
Sbjct: 313 IELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFHERVKAFQNWQYAQMQLSKRRENRGR 372
Query: 417 ERLNTLESNPDVKGAEYDRVKQSISRDKRSILDQMNRSWLIRECILEEFTIFHETQFLIT 476
L D E D + + R ++ D + + RE +E F + F +
Sbjct: 373 FELANRADKLDQAQQEVDEWQGKVQRCQQQFDD--ISAEIKRE--MERFELTRVKDFKVN 428
Query: 477 DCFQRWIEINLRYTNNNVDNWEKICKKLRDM 507
++IE + + V WE R++
Sbjct: 429 --IIKYIEDQMAHQQQIVSYWEAFAPFAREI 457
>Hs4507143 [U] KOG2527 Sorting nexin SNX11
Length = 162
Score = 50.4 bits (119), Expect = 6e-06
Identities = 36/103 (34%), Positives = 54/103 (51%), Gaps = 10/103 (9%)
Query: 148 KHTNYLVKHLTPLPNTDPSDDRTVVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNA 207
+ T Y ++ T LP + TV RRYSDF+WL+ L R+ +VP LP K Q
Sbjct: 45 RFTTYEIRVKTNLPIFKLKES-TVRRRYSDFEWLRSELERESKV-VVPPLPGKAFLRQLP 102
Query: 208 --------DPLFLAKRRKGLSRFINLVMKHPVLRSDDLVLTFL 242
D F+ +R++GL +FIN V HP+ +++ + FL
Sbjct: 103 FRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFL 145
>Hs20070247_1 [ZUD] KOG2101 Intermediate filament-like protein sorting nexins and
related proteins containing PX (PhoX) domain(s)
Length = 118
Score = 50.1 bits (118), Expect = 8e-06
Identities = 27/72 (37%), Positives = 44/72 (60%), Gaps = 1/72 (1%)
Query: 171 VVRRYSDFDWLQDVLLRKYPFRMVPELPPKKIGSQNADPLFLAKRRKGLSRFINLVMKHP 230
V RRY++ D L + L +++P M ++P K+I N DP F+ +RR GL+ FI ++++P
Sbjct: 47 VFRRYAEVDKLYNTLKKQFP-AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYP 105
Query: 231 VLRSDDLVLTFL 242
L + V FL
Sbjct: 106 ELYNHPDVRAFL 117
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,786,824
Number of Sequences: 60738
Number of extensions: 1336352
Number of successful extensions: 3602
Number of sequences better than 1.0e-05: 17
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3583
Number of HSP's gapped (non-prelim): 17
length of query: 512
length of database: 30,389,216
effective HSP length: 111
effective length of query: 401
effective length of database: 23,647,298
effective search space: 9482566498
effective search space used: 9482566498
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)