ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1649 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1649 585093 583675 -473
(473 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL221w [G] KOG2504 Monocarboxylate transporter 397 e-110
YNL125c [G] KOG2504 Monocarboxylate transporter 183 6e-46
Hs20559959 [G] KOG2504 Monocarboxylate transporter 77 4e-14
YOR306c [G] KOG2504 Monocarboxylate transporter 72 1e-12
Hs18699730 [G] KOG2504 Monocarboxylate transporter 72 1e-12
Hs4759112 [G] KOG2504 Monocarboxylate transporter 72 2e-12
YOL119c [G] KOG2504 Monocarboxylate transporter 66 1e-10
Hs5730045 [G] KOG2504 Monocarboxylate transporter 64 6e-10
7292012 [G] KOG2504 Monocarboxylate transporter 61 3e-09
Hs22064599 [G] KOG2504 Monocarboxylate transporter 61 4e-09
Hs7019529 [G] KOG2504 Monocarboxylate transporter 60 5e-09
7302291 [G] KOG2504 Monocarboxylate transporter 59 1e-08
CE21446 [G] KOG2504 Monocarboxylate transporter 59 2e-08
CE20478 [G] KOG2504 Monocarboxylate transporter 59 2e-08
CE04864 [G] KOG2504 Monocarboxylate transporter 57 6e-08
CE02803 [G] KOG2504 Monocarboxylate transporter 57 6e-08
CE12336 [G] KOG2504 Monocarboxylate transporter 54 5e-07
7295260 [G] KOG4686 Predicted sugar transporter 54 7e-07
7295764 [G] KOG2504 Monocarboxylate transporter 53 9e-07
Hs4759118 [G] KOG2504 Monocarboxylate transporter 51 4e-06
CE29573 [G] KOG2504 Monocarboxylate transporter 51 4e-06
7290288 [G] KOG2504 Monocarboxylate transporter 50 1e-05
>YKL221w [G] KOG2504 Monocarboxylate transporter
Length = 473
Score = 397 bits (1021), Expect = e-110
Identities = 202/456 (44%), Positives = 282/456 (61%), Gaps = 8/456 (1%)
Query: 24 SSEDDYN-----KISVPDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGT 78
+ +DD N I VPDGGYGW TWGA SGY++YL++Y+ ++ + G+
Sbjct: 20 NGKDDINGNTSISIEVPDGGYGWFILLAFILYNFSTWGANSGYAIYLAHYLENNTFAGGS 79
Query: 79 DLDYAAIGGLSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYL 138
LDYA+IGGL+F GLF AP+ +L S + ++ LGI+ Q ++LLAAF+ LW++YL
Sbjct: 80 KLDYASIGGLAFSCGLFFAPVITWLYHIFSIQFIIGLGILFQGAALLLAAFSVTLWEIYL 139
Query: 139 TQGVAISFGLGAICFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDGKNV 198
TQGV I FGL I P+ T++ WFR KR VFNL MQ I+ + V
Sbjct: 140 TQGVLIGFGLAFIFIPSVTLIPLWFRNKRSLASGIGTAGSGLGGIVFNLGMQSILQKRGV 199
Query: 199 RWALISQCIICSVLSTIALILVRTRKEEVEKHSEE-PSRVIEWGMFKYPVVWLLIGWVCF 257
+WALI+QCIIC+ LSTIAL+L RT + + +H ++++ + VWLL G+V F
Sbjct: 200 KWALIAQCIICTSLSTIALMLTRTTHQGLRQHKRSYKFELLDYDVLSNFAVWLLFGFVSF 259
Query: 258 TMLGYVIQLYSLFSFTVSLGYTSRQGSIVSSMICLGALLGRPMVGFLSDKFGPVTTAMFC 317
MLGYV+ LYSL FTVSLGYTS+QGS VS M+ +G+LLGRP+VG ++DK+G +T M
Sbjct: 260 AMLGYVVLLYSLSDFTVSLGYTSKQGSYVSCMVSVGSLLGRPIVGHIADKYGSLTVGMIL 319
Query: 318 HLLVGILCYAMWIPCRNYATIIVFALFEGMMMGTIWPLLTSIITRLVGLRKLESVYSVIW 377
HL++ ILC+AMWIPC+N AT I F L G +MGTIWP + SI+TR+VGL+KL + W
Sbjct: 320 HLVMAILCWAMWIPCKNLATAIRFGLLVGSIMGTIWPTIASIVTRIVGLQKLPGTFGSTW 379
Query: 378 MFIGACSIVSPVIGLKLKKDHYKEGENAYIFTXXXXXXXXXXXXXXXXXMRGFLIARDKI 437
+F+ A ++V+P+IGL+L+ N Y T +RGF+IARD+I
Sbjct: 380 IFMAAFALVAPIIGLELRST--DTNGNDYYRTAIFVGFAYFGVSLCQWLLRGFIIARDEI 437
Query: 438 SMKEKTAYDDGELHFRPDLRDALQGTLCWKNLYRKV 473
+++E + D ELH L + +K L R+V
Sbjct: 438 AVREAYSADQNELHLNVKLSHMSKCLFRYKQLPRRV 473
>YNL125c [G] KOG2504 Monocarboxylate transporter
Length = 673
Score = 183 bits (464), Expect = 6e-46
Identities = 115/388 (29%), Positives = 180/388 (45%), Gaps = 18/388 (4%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFGVGL 94
PDGGYGW TWG + + V L+YY+ D Y + DYA I GL+ +G
Sbjct: 207 PDGGYGWVVTFCVFLTMFSTWGCNASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQ 266
Query: 95 FLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICFP 154
L+PL L+ + +L G V + LLA+F TKLWQ+Y+TQG + + I P
Sbjct: 267 LLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVP 326
Query: 155 NTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKII-DGKNVRWALISQCIICSVLS 213
TT++ WF KKR V+ L+ K++ D N RW L I CS+
Sbjct: 327 ATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISV 386
Query: 214 TIALILVRTRKEEVEKHSEEPSRVIEW--GMFKY-----PVVWLLIGWVCFTMLGYVIQL 266
+A+ L++ R + P + E MF P V L+ W F + Y + +
Sbjct: 387 LVAIALLKERNPTPAIGLKSPRAMFEQLKAMFSLKVITKPFVVLIALWFMFALFAYNMMV 446
Query: 267 YSLFSFTVSLGYTSRQGSIVSSMICLGALLGRPMVGFLSDKFGPVTTAMFCHLLVGILCY 326
++L S+ +S G +S S +++++ +GRP++G DKFG + L+ I +
Sbjct: 447 FTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFGRANVTIVLTTLLTIYMF 506
Query: 327 AMWIPCRNYATIIVFALFEGMMMGTIWPLLTSIITRLVGLRKLESVYSVIWMFIGACS-- 384
A WIP + +I F++ G +G + T +I +V + + W F+ C
Sbjct: 507 AFWIPAHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEE----FLPAWAFVNYCGAP 562
Query: 385 --IVSPVI--GLKLKKDHYKEGENAYIF 408
+V VI L ++KD +A IF
Sbjct: 563 FLLVCEVIAQALTVEKDKSNPYLHAQIF 590
>Hs20559959 [G] KOG2504 Monocarboxylate transporter
Length = 426
Score = 77.4 bits (189), Expect = 4e-14
Identities = 74/359 (20%), Positives = 148/359 (40%), Gaps = 14/359 (3%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFGVGL 94
PDGG+GW +G + V+ ++ + + + A+IG V
Sbjct: 8 PDGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIG---IAVQQ 64
Query: 95 FLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICFP 154
F +P+ + L K + V++ G ++ + +LLA+FAT L +YL+ G+ G P
Sbjct: 65 FGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAP 124
Query: 155 NTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDGKNVRWA-LISQCIICSVLS 213
++ +F ++R F Q ++ R + L+ + +++
Sbjct: 125 TLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALSLHLVA 184
Query: 214 TIALILVRTRKEE--VEKHSEEPSRVIEWGMF-KYPVVWLLIGWVCFTMLGYVIQLYSLF 270
AL+ + E+ V + + ++ G F +Y V LI GY I L
Sbjct: 185 CGALLRPPSLAEDPAVGGPRAQLTSLLHHGPFLRYTVALTLIN------TGYFIPYLHLV 238
Query: 271 SFTVSLGYTSRQGSIVSSMICLGALLGRPMVGFLSDKF-GPVTTAMFCHLLVGILCYAMW 329
+ L + + + S++ + L+GR + G+L D GPVT + + + A++
Sbjct: 239 AHLQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSLALF 298
Query: 330 IPCRNYATIIVFALFEGMMMGTIWPLLTSIITRLVGLRKLESVYSVIWMFIGACSIVSP 388
+ ++ A+ G G + PL S++ L+G R++ ++ M ++ P
Sbjct: 299 PVAQAPTALVALAVAYGFTSGALAPLAFSVLPELIGTRRIYCGLGLLQMIESIGGLLGP 357
>YOR306c [G] KOG2504 Monocarboxylate transporter
Length = 521
Score = 72.4 bits (176), Expect = 1e-12
Identities = 81/398 (20%), Positives = 159/398 (39%), Gaps = 34/398 (8%)
Query: 22 TDSSEDDYNKI-SVPDGGY-GWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTD 79
+D ED +I S P+GG+ W +G + V S+ +
Sbjct: 86 SDKEEDSNEEIESFPEGGFKAWVVTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESV- 144
Query: 80 LDYAAIGGLSFGVGLFLAP----LFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQ 135
+ IG L F + LF+ + ++ + ++++G V + A +TK W
Sbjct: 145 ---STIGWL-FSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWH 200
Query: 136 VYLTQGVAISFGLGAICFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDG 195
L+ + FG G + P ++ A +F K+R VF + ++
Sbjct: 201 FILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSM 260
Query: 196 KN-------VRWALISQCIICSVLSTIALILVRTRKEEVEKHSEEPSRVIEWGMFKY--- 245
K+ W + + + L T+++ILV+ R V ++S++ + + Y
Sbjct: 261 KSDTDPTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYILQ 320
Query: 246 ----------PVVWLLIGWVCFTMLGYVIQLYSLFSFTVSLGYTSRQGSIVSSMICLGAL 295
++ ++G V F+ L L S+ S G ++ + +I + +
Sbjct: 321 CFDAKAFLDMKYLFCVLGTV-FSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGI 379
Query: 296 LGRPMVGFLSDKFGPVTTAMFCHLLVGILCYAMWIPC-RNYATIIVFALFEGMMMGTIWP 354
GR + G+LSDKFG A+ L + I+ + W+P N + V + G G+++
Sbjct: 380 PGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFS 439
Query: 355 LLTSIITRLVGLRKLESVYSVIWMFIGACSIVS-PVIG 391
LL ++ + YS ++ +G ++V P+ G
Sbjct: 440 LLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITG 477
>Hs18699730 [G] KOG2504 Monocarboxylate transporter
Length = 515
Score = 72.4 bits (176), Expect = 1e-12
Identities = 76/393 (19%), Positives = 150/393 (37%), Gaps = 23/393 (5%)
Query: 18 VESLTDSSEDDYNKISVPDGGYGWXXXXXXXXXXXCTWGATSGYSV-YLSYYMT-SDKYE 75
VE ++ + + P+GG+GW +G + V ++S T K +
Sbjct: 48 VELAGPATAEPHEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDD 107
Query: 76 TGTDLDYAAIGGLSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQ 135
A +G LS G+ F P+ + +K ++G V V ++ ++F + +
Sbjct: 108 DKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEP 167
Query: 136 VYLTQGVAISFGLGAICFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDG 195
+YLT G+ + G P+ I+ +F+K+ + L ++ +ID
Sbjct: 168 LYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDS 227
Query: 196 KNVRWALISQCIICSVL----STIALILVRTRKEE---------VEKHSEEPSRVIEWGM 242
+ + L CI VL T + T+ +E K P ++ + +
Sbjct: 228 VGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAI 287
Query: 243 FKYPVVWLLIGWVCFTMLGYVIQLYSLFSFTVSLGYTSRQGSIVSSMICLGALLGRPMVG 302
FK + + + GY + L + +V I + + +GR + G
Sbjct: 288 FKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFG 347
Query: 303 FLSDKFGPVTTAMFCHLL----VGILCYAMWIP-CRNYATIIVFALFEGMMMGTIWPLLT 357
++D + P ++ +L +G++ +M IP C + +I L G+ G ++
Sbjct: 348 RIAD-YVPGVKKVYLQVLSFFFIGLM--SMMIPLCSIFGALIAVCLIMGLFDGCFISIMA 404
Query: 358 SIITRLVGLRKLESVYSVIWMFIGACSIVSPVI 390
I LVG + + + F+ V P I
Sbjct: 405 PIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPI 437
>Hs4759112 [G] KOG2504 Monocarboxylate transporter
Length = 465
Score = 71.6 bits (174), Expect = 2e-12
Identities = 73/373 (19%), Positives = 144/373 (38%), Gaps = 18/373 (4%)
Query: 32 ISVPDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFG 91
+ PDGG+GW ++ SV+ + ++ G D A I +
Sbjct: 13 VKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELI--QEFGIGYS-DTAWISSILLA 69
Query: 92 VGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAI 151
+ PL + + + + V+L+G + ++ ++ A+F + QVYLT GV GL
Sbjct: 70 MLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALN 129
Query: 152 CFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIID------GKNVRWALISQ 205
P+ ++ +F K+R + Q + D G + L+
Sbjct: 130 FQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLN 189
Query: 206 CIICSVLSTIALILVRTRKEEVEKHSEEPS-RVIEWGMFKYPVVWLLIGWVCFTMLGYVI 264
C +C+ L ++ + PS R+++ +F+ L +LG +
Sbjct: 190 CCVCAALMRPLVVTA-----QPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFV 244
Query: 265 QLYSLFSFTVSLGYTSRQGSIVSSMICLGALLGRPMVGFLS--DKFGPVTTAMFC-HLLV 321
+ S+ LG + + + +++ + RP GF++ K P + +F +
Sbjct: 245 PPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFF 304
Query: 322 GILCYAMWIPCRNYATIIVFALFEGMMMGTIWPLLTSIITRLVGLRKLESVYSVIWMFIG 381
L +Y ++VF +F G+ G + L ++ +VG K S ++ +
Sbjct: 305 NGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEA 364
Query: 382 ACSIVSPVIGLKL 394
+V P G KL
Sbjct: 365 VAVLVGPPSGGKL 377
>YOL119c [G] KOG2504 Monocarboxylate transporter
Length = 501
Score = 65.9 bits (159), Expect = 1e-10
Identities = 66/298 (22%), Positives = 115/298 (38%), Gaps = 15/298 (5%)
Query: 112 VLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICFPNTTIVAPWFRKKRXXXX 171
++ G V+ + A +WQ L V G G + P VA WF K+R
Sbjct: 167 LMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIAT 226
Query: 172 XXXXXXXXXXXXVFNLSMQKIIDGKNVRWALISQCIICSVLSTIALILVRTRKEEVEKHS 231
VF + ++K+ +WA+ IC A +L R R + V +
Sbjct: 227 SISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLARERTKPVVQPF 286
Query: 232 EEPSRVIEW---GMFKYPVVWLLIGWVCFTMLGYVIQLYSLFSFTVSL-GYTSRQG---S 284
+ + V +W +F + + L G F +G SL S L Y+ +G +
Sbjct: 287 KSKAEVAKWYISSVFNWR--YFLEGKFLFVAIGASFAESSLTSCATYLASYSMTRGNTEN 344
Query: 285 IVSSMICLG---ALLGRPMVGFLSDKF-GPVTTAMFCHLLVGILCYAMWIPC-RNYATII 339
+ +MI +LGR + G+ +DKF G + + + + MW+P N +
Sbjct: 345 VAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGNTKVLW 404
Query: 340 VFALFEGMMMGTIWPLLTSIITRLVGLRKLESVYSVIWMFIGACSI-VSPVIGLKLKK 396
+ G G+I L I ++ Y+ +++ +I V P+ G + K
Sbjct: 405 AYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLIGK 462
>Hs5730045 [G] KOG2504 Monocarboxylate transporter
Length = 613
Score = 63.5 bits (153), Expect = 6e-10
Identities = 67/355 (18%), Positives = 137/355 (37%), Gaps = 33/355 (9%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAA--IGGLSFGV 92
P+GG+GW +G + + S + +K E +++ A +G L+ G+
Sbjct: 169 PEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEK-EKNRQVEFQAAWVGALAMGM 227
Query: 93 GLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAIC 152
F +P+ + + + G V + + ++F + L Y T G+ G
Sbjct: 228 IFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAF 287
Query: 153 FPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDGKNVRWALISQCIICSVL 212
P+ I+ +F+++ +F++S +I + L + S
Sbjct: 288 QPSLVILGHYFQRR----LGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTF 343
Query: 213 STIALILVRTRKEEVEKHSEEPSR----------------VIEWGMFKYPVVWLLIGWVC 256
+ ++L T + + + PS+ +F+ + +
Sbjct: 344 MFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIA 403
Query: 257 FTMLGYVIQLYSLFSFTVSLGYTSRQGSIVSSMICLGAL--LGRPMVGFLSDKFG---PV 311
LGY + L + ++ ++ ++C+GA LGR + G +SD +
Sbjct: 404 AAALGYFVPYVHLMKYVEEEFSEIKETWVL--LVCIGATSGLGRLVSGHISDSIPGLKKI 461
Query: 312 TTAMFCHLLVGILCYAMWIP-CRNYATIIVFALFEGMMMGTIWPLLTSIITRLVG 365
+ LL+G++ +M IP CR++ +IV LF G+ G ++ I LVG
Sbjct: 462 YLQVLSFLLLGLM--SMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVG 514
>7292012 [G] KOG2504 Monocarboxylate transporter
Length = 816
Score = 61.2 bits (147), Expect = 3e-09
Identities = 43/156 (27%), Positives = 66/156 (41%), Gaps = 10/156 (6%)
Query: 19 ESLTDSSEDDYNKISV-------PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTS 71
E D+ EDD ++ SV PDGGYGW G + ++L ++
Sbjct: 49 EDNQDNDEDDDDEESVYGELPPPPDGGYGWVICFASFMCNMIVDGIAYTFGIFLEEFVAY 108
Query: 72 DKYETGTDLDYAAIGGLSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFAT 131
GT A +G L GV L P+ + L K + V + G ++ ++ +L+ F+T
Sbjct: 109 FHEGKGT---VAWVGSLLSGVYLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFST 165
Query: 132 KLWQVYLTQGVAISFGLGAICFPNTTIVAPWFRKKR 167
+ + T G FG G I P V +F KR
Sbjct: 166 NVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKR 201
>Hs22064599 [G] KOG2504 Monocarboxylate transporter
Length = 579
Score = 60.8 bits (146), Expect = 4e-09
Identities = 68/364 (18%), Positives = 143/364 (38%), Gaps = 14/364 (3%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFGVGL 94
PDGG+GW ++G S+ L++ ++ ++ D A I L+ V
Sbjct: 141 PDGGWGWVVAAAAFAINGLSYGLLR--SLGLAFPDLAEHFDRSAQ-DTAWISALALAVQQ 197
Query: 95 FLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICFP 154
+P+ + L + A+ V+++G V+ ++ + +AFA+ L +YL G+ FG + P
Sbjct: 198 AASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAP 257
Query: 155 NTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDGKNVRWALISQCIICSVLST 214
++ +F ++R + ++Q ++D R AL+ I L+
Sbjct: 258 ALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTP 317
Query: 215 I-ALILVRTRKEEVEKHSEEPSRVIEWGMFKYPVVWLLIGWVCFTMLGYVIQLYSLFSFT 273
AL+L + P + +F + GY + L
Sbjct: 318 CGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRAFSIFALGTALVGGGYFVPYVHLAPHA 377
Query: 274 VSLGYTSRQGSIVSSMICLGALLGRPMVGFLSDKFGPVTTAMFCHLLVGILCYAMW---- 329
+ G ++V ++ +G R + G+L+D+ G V + + +W
Sbjct: 378 LDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQ-GWVPLPRLLAVFGALTGLGLWVVGL 436
Query: 330 IPCRN-----YATIIVFALFEGMMMGTIWPLLTSIITRLVGLRKLESVYSVIWMFIGACS 384
+P ++ A+ G+ G+ PL+ ++ LVG+ + ++ M +
Sbjct: 437 VPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVGVGGVVQATGLVMMLMSLGG 496
Query: 385 IVSP 388
++ P
Sbjct: 497 LLGP 500
>Hs7019529 [G] KOG2504 Monocarboxylate transporter
Length = 504
Score = 60.5 bits (145), Expect = 5e-09
Identities = 76/387 (19%), Positives = 148/387 (37%), Gaps = 36/387 (9%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFGVGL 94
PDGG+GW +G SV+ M ++ G D A + + +
Sbjct: 13 PDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRD--FDAGYS-DTAWVSSIMLAMLY 69
Query: 95 FLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICFP 154
P+ + L+ + + V+L G ++ + ++LA+FAT+L ++YLT GV GL P
Sbjct: 70 GTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQP 129
Query: 155 NTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIID------GKNVRWALISQCII 208
+ ++ +F ++R + Q++++ G + L+ C
Sbjct: 130 SLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCA 189
Query: 209 C-SVLSTIALILVRTRKEEV-EKHSEEPS---------RVIEWGMFKYPVVWLLIGWVC- 256
C +V+ R R++ ++ + P ++ E + P LL VC
Sbjct: 190 CGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPWVRPRRRLLDLAVCT 249
Query: 257 -----------FTM-LGYVIQLYSLFSFTVSLGYTSRQGSIVSSMICLGALLGRPMVGFL 304
F M LG + L ++ G + + S++ ++ RP G L
Sbjct: 250 DRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGAL 309
Query: 305 SD--KFGPVTTAMF-CHLLVGILCYAMWIPCRNYATIIVFALFEGMMMGTIWPLLTSIIT 361
+ + P +F LL L R+Y ++ F + G+ G + L ++
Sbjct: 310 AGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLM 369
Query: 362 RLVGLRKLESVYSVIWMFIGACSIVSP 388
VG + S ++ + A ++ P
Sbjct: 370 AAVGAPRFPSALGLVLLVEAAAVLIGP 396
>7302291 [G] KOG2504 Monocarboxylate transporter
Length = 800
Score = 59.3 bits (142), Expect = 1e-08
Identities = 42/148 (28%), Positives = 63/148 (42%), Gaps = 9/148 (6%)
Query: 23 DSSEDDYNKISVPDGGYGWXXXXXXXXXXXCTWGATSGY---SVYLSYYMTSDKYETGTD 79
DSS + +PDGGYGW G + + +V L Y +T
Sbjct: 27 DSSSTEKKTPKMPDGGYGWVVVFASLVVSLIADGLSFSFGLINVELLEYFGESTSKT--- 83
Query: 80 LDYAAIGGLSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLT 139
A I L F V L + P+++ L+ K +K+ +LG VV L++F + + +T
Sbjct: 84 ---AWISSLFFSVPLLMGPIWSNLVDKYGCRKMTILGGVVSAFGFALSSFCNSIEMLMVT 140
Query: 140 QGVAISFGLGAICFPNTTIVAPWFRKKR 167
G+ GLG +A WF KKR
Sbjct: 141 FGIISGLGLGIGYVTAVVSIAFWFDKKR 168
>CE21446 [G] KOG2504 Monocarboxylate transporter
Length = 666
Score = 58.9 bits (141), Expect = 2e-08
Identities = 50/223 (22%), Positives = 88/223 (39%), Gaps = 6/223 (2%)
Query: 7 DIINKEAT-ACSVESLTDSSEDDYNKISVPDGGYGWXXXXXXXXXXXCTWGATSGYSVYL 65
D KE T A + + ++ K++ PDGGYGW G L
Sbjct: 11 DAEKKEVTVAVTAAENFEEQVEEVGKVTPPDGGYGWVVVAASFLVNMAVDGVIYTCGKIL 70
Query: 66 SYYMTSDKYETGTDLDYAAIGGLSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVL 125
+ +D++ G+ A+ + G PL + + + V + G ++ + L
Sbjct: 71 -VPIWADQF--GSTSVAGAVISILTGCYYLAGPLASSFVNVFGIRSVAIAGSILATTAFL 127
Query: 126 LAAFATKLWQVYLTQGVAISFGLGAICFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVF 185
L+ FA+ +W++YL GV G G + P+ I++ +F KKR VF
Sbjct: 128 LSRFASTIWELYLLFGVLGGIGFGCMYLPSIVILSTYFAKKRSVATGIAVCGSGIGTMVF 187
Query: 186 NLSMQKIID--GKNVRWALISQCIICSVLSTIALILVRTRKEE 226
+ + D GK+V ++ I S +L+ + E
Sbjct: 188 STINGPVFDYFGKDVGSFMVYLAAIAISGSLFSLLFAPLKATE 230
>CE20478 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 58.9 bits (141), Expect = 2e-08
Identities = 50/223 (22%), Positives = 88/223 (39%), Gaps = 6/223 (2%)
Query: 7 DIINKEAT-ACSVESLTDSSEDDYNKISVPDGGYGWXXXXXXXXXXXCTWGATSGYSVYL 65
D KE T A + + ++ K++ PDGGYGW G L
Sbjct: 11 DAEKKEVTVAVTAAENFEEQVEEVGKVTPPDGGYGWVVVAASFLVNMAVDGVIYTCGKIL 70
Query: 66 SYYMTSDKYETGTDLDYAAIGGLSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVL 125
+ +D++ G+ A+ + G PL + + + V + G ++ + L
Sbjct: 71 -VPIWADQF--GSTSVAGAVISILTGCYYLAGPLASSFVNVFGIRSVAIAGSILATTAFL 127
Query: 126 LAAFATKLWQVYLTQGVAISFGLGAICFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVF 185
L+ FA+ +W++YL GV G G + P+ I++ +F KKR VF
Sbjct: 128 LSRFASTIWELYLLFGVLGGIGFGCMYLPSIVILSTYFAKKRSVATGIAVCGSGIGTMVF 187
Query: 186 NLSMQKIID--GKNVRWALISQCIICSVLSTIALILVRTRKEE 226
+ + D GK+V ++ I S +L+ + E
Sbjct: 188 STINGPVFDYFGKDVGSFMVYLAAIAISGSLFSLLFAPLKATE 230
>CE04864 [G] KOG2504 Monocarboxylate transporter
Length = 556
Score = 57.0 bits (136), Expect = 6e-08
Identities = 41/170 (24%), Positives = 63/170 (36%), Gaps = 5/170 (2%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTS-DKYETGTDLDYAAIGGLSFGVG 93
PDGG+GW G + + M + T T L + + G + G G
Sbjct: 15 PDGGWGWVVVIGSFFIHVFADGFVYSFGILAEKLMIEFNSNNTMTSLIVSMLTGFTLGAG 74
Query: 94 LFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICF 153
PL + + K + ++G V V LL+ FAT++W ++ GV + G G +
Sbjct: 75 ----PLASAVCNKYGCRITTIIGAGVAFVGCLLSCFATEIWHFVISVGVIMGIGFGLVYC 130
Query: 154 PNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDGKNVRWALI 203
P IV +F KR VF II R+ +
Sbjct: 131 PAIVIVTMYFESKRSLATGIAVAGAGVGAVVFGPINTFIISNYGWRYVFV 180
>CE02803 [G] KOG2504 Monocarboxylate transporter
Length = 808
Score = 57.0 bits (136), Expect = 6e-08
Identities = 46/205 (22%), Positives = 73/205 (35%), Gaps = 6/205 (2%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFGVGL 94
PDGGYGW G ++ +S + Y ++Y+ L IG L G L
Sbjct: 84 PDGGYGWVIVFAAFMSNLVVDGISTAFSEFKQSY--KERYQESDGLT-VFIGSLIIGTYL 140
Query: 95 FLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICFP 154
+ PL + L K + V++ G ++ ++ ++A + ++ L GV G G I P
Sbjct: 141 LVGPLVSALCNKYEQRYVVMAGGLISGIAFMIAPASPNIYVFMLIYGVMGGLGFGMIYLP 200
Query: 155 NTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNLSMQKIIDG---KNVRWALISQCIICSV 211
+V +F KR + L Q I + W L C
Sbjct: 201 AIVVVGFYFDSKRAMATGISVAGSGVGTFLVPLICQVCIANLGWQKTIWVLAVMIFSCVF 260
Query: 212 LSTIALILVRTRKEEVEKHSEEPSR 236
+ L E+ EP R
Sbjct: 261 YGYLYRPLPMVDLNEIRDQEMEPLR 285
>CE12336 [G] KOG2504 Monocarboxylate transporter
Length = 596
Score = 53.9 bits (128), Expect = 5e-07
Identities = 51/229 (22%), Positives = 90/229 (39%), Gaps = 16/229 (6%)
Query: 10 NKEATACSVESLTDSSEDDYNKISVPDGGYGWXXXXXXXXXXXCTWGA--TSGYSVYLSY 67
+++A A + +D I+ PDGGYGW G T G + ++
Sbjct: 9 DEKAAAHQDPETVEKELEDAGFIAPPDGGYGWAIVAASFLLNMIVDGVIFTVGKILQPAW 68
Query: 68 YMTSDKYETGTDLDYAAIGGLSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLA 127
+ E + + + G F F P+ + L ++V L G ++ + LL+
Sbjct: 69 VHSFGISEASAAMTMSILSGCYF----FAGPIASVLCNVFGCRQVALAGSLIAALGFLLS 124
Query: 128 AFATKLWQVYLTQGVAISFGLGAICFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNL 187
A ++ +Y++ G+ G G + P I++ +F KKR VF L
Sbjct: 125 ISAPNIYVLYVSFGLIAGAGFGMMYLPAIVIISQYFAKKRSVATGIAVCGSGIGTTVFAL 184
Query: 188 SMQKIIDGKNVRWALISQCIICSVLSTI----ALILVR---TRKEEVEK 229
+ D W Q ++ + TI A IL+R K+++EK
Sbjct: 185 LNDVVWDFVGGDW---KQFLVYTAAVTISGLGACILLRPLKPSKDQIEK 230
>7295260 [G] KOG4686 Predicted sugar transporter
Length = 478
Score = 53.5 bits (127), Expect = 7e-07
Identities = 65/295 (22%), Positives = 118/295 (39%), Gaps = 32/295 (10%)
Query: 88 LSFGVGLFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFG 147
L F G + LF L +LL+G ++ +L AF W + L + + FG
Sbjct: 104 LCFVGGFLIDRLFGIRLGTIIYMMILLVGQLIFACGGILDAF----WMMILGRFI---FG 156
Query: 148 LGA--ICFPNTTIVAPWFRKKRXXXXXXXXXXXXXXXXVFNL-SMQKIIDGKNVRW---- 200
+GA + + WF+ K N MQ I + + +
Sbjct: 157 IGAESLAVAQNSYAVLWFKGKELNMVFGLQLSVARFGSTVNFWVMQPIYEYVSNFYKGHT 216
Query: 201 ----ALISQCIICSVLSTIALIL--VRTRKEEVEKHSEEPSRVIE--WGMFKYPVVWLLI 252
L+ + C + T ALIL + R E + + + P+ I +F + + ++
Sbjct: 217 ALGVVLLLATLTCVMSMTCALILGWMDKRAERILQRNNNPAGQIPKLTDVFSFKPPFWMV 276
Query: 253 GWVCFTMLGYVIQLYSLFS-----FTVSLGYTSRQGSIVSSMICLGALLGRPMVGFLSDK 307
+C + Y + ++ + F G + + + V S++ L A + P+ GF+ DK
Sbjct: 277 SIIC---VAYYVAIFPFIALGQNFFVDRFGLSPAEANTVDSLVYLIAAVSSPVFGFIIDK 333
Query: 308 FGPVTTAMFCHLLVGILCYAM--WIPCRNYATIIVFALFEGMMMGTIWPLLTSII 360
G T +F L I +A+ + Y +I+ L M+ ++WPL+ II
Sbjct: 334 LGRNVTWVFTATLTTIGAHALLTFTQLTPYVGMIIMGLSYSMLAASLWPLVALII 388
>7295764 [G] KOG2504 Monocarboxylate transporter
Length = 1131
Score = 53.1 bits (126), Expect = 9e-07
Identities = 32/133 (24%), Positives = 60/133 (45%), Gaps = 4/133 (3%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFGVGL 94
PDGG+GW T G Y + Y + +G +L +G LS+ V +
Sbjct: 411 PDGGWGWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIEL----LGALSWSVSM 466
Query: 95 FLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICFP 154
L K S + + ++G +V + +L +FAT+ QV + G+ G+ +
Sbjct: 467 VATSFVVSLCRKRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREA 526
Query: 155 NTTIVAPWFRKKR 167
+T ++ +F+++R
Sbjct: 527 STVMLGNYFKRRR 539
>Hs4759118 [G] KOG2504 Monocarboxylate transporter
Length = 523
Score = 50.8 bits (120), Expect = 4e-06
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 3/134 (2%)
Query: 34 VPDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTSDKYETGTDLDYAAIGGLSFGVG 93
VPDGG+GW T+G + V+ + M S E+ + + + I + V
Sbjct: 18 VPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFN-ESNSRISW--IISICVFVL 74
Query: 94 LFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICF 153
F APL L + + V++LG ++ + ++ A+F+ ++ +Y+ G+ G
Sbjct: 75 TFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFL 134
Query: 154 PNTTIVAPWFRKKR 167
P TI++ +F K+R
Sbjct: 135 PTVTILSQYFGKRR 148
>CE29573 [G] KOG2504 Monocarboxylate transporter
Length = 594
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/134 (27%), Positives = 54/134 (39%), Gaps = 5/134 (3%)
Query: 35 PDGGYGWXXXXXXXXXXXCTWGATSGYSVYLSYYMTS-DKYETGTDLDYAAIGGLSFGVG 93
PDGG+GW G + V + M T L + + GL+ G G
Sbjct: 18 PDGGWGWVVVLGSFFVHVFADGFVYSFGVLVETLMEEFHASNTMAALIISLLTGLTLGSG 77
Query: 94 LFLAPLFNYLLIKSSAKKVLLLGIVVQNVSVLLAAFATKLWQVYLTQGVAISFGLGAICF 153
PL + + K + + G V V L+ FAT +W + +T GV + G G +
Sbjct: 78 ----PLASAVCNKYGCRITTITGAGVAFVGCALSYFATAMWHIVITVGVIMGTGFGLMYC 133
Query: 154 PNTTIVAPWFRKKR 167
P IV +F KR
Sbjct: 134 PAIVIVTMYFENKR 147
>7290288 [G] KOG2504 Monocarboxylate transporter
Length = 715
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/137 (24%), Positives = 65/137 (47%), Gaps = 5/137 (3%)
Query: 258 TMLGYVIQLYSLFSFTVSLGYTSRQGSIVSSMICLGALLGRPMVGFLSDKFGPVTTAMFC 317
T +G+ + + ++ +L T S + S I + +GR ++G++SDK P +
Sbjct: 527 TSIGFNVPYLYVVAYAETLKLTKTDASYLISTIGVANTVGRIILGYISDK--PWVNRLLV 584
Query: 318 HLLVGILC---YAMWIPCRNYATIIVFALFEGMMMGTIWPLLTSIITRLVGLRKLESVYS 374
+ + C AM C ++ ++ + G +G L + I+ L+GL KL + +
Sbjct: 585 YNVCLTACGVSTAMVPLCHDFQSLAFYCCVFGFTIGAYVGLTSVILVDLLGLDKLTNAFG 644
Query: 375 VIWMFIGACSIVSPVIG 391
++ +F G S + P IG
Sbjct: 645 LLLLFQGIASFIGPPIG 661
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.326 0.141 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,827,278
Number of Sequences: 60738
Number of extensions: 928331
Number of successful extensions: 2844
Number of sequences better than 1.0e-05: 22
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2792
Number of HSP's gapped (non-prelim): 42
length of query: 473
length of database: 30,389,216
effective HSP length: 110
effective length of query: 363
effective length of database: 23,708,036
effective search space: 8606017068
effective search space used: 8606017068
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)