ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1691 good L KOG2310 Replication, recombination and repair DNA repair exonuclease MRE11
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1691 600876 602957 694
(694 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YMR224c [L] KOG2310 DNA repair exonuclease MRE11 726 0.0
SPAC13C5.07 [L] KOG2310 DNA repair exonuclease MRE11 488 e-137
Hs5031921 [L] KOG2310 DNA repair exonuclease MRE11 393 e-109
Hs5031923 [L] KOG2310 DNA repair exonuclease MRE11 392 e-109
At5g54260 [L] KOG2310 DNA repair exonuclease MRE11 367 e-101
7297844 [L] KOG2310 DNA repair exonuclease MRE11 348 2e-95
CE06573 [L] KOG2310 DNA repair exonuclease MRE11 310 4e-84
ECU05g1280 [L] KOG2310 DNA repair exonuclease MRE11 268 2e-71
>YMR224c [L] KOG2310 DNA repair exonuclease MRE11
Length = 692
Score = 726 bits (1873), Expect = 0.0
Identities = 375/700 (53%), Positives = 485/700 (68%), Gaps = 24/700 (3%)
Query: 8 PAVDTIRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGDLFHVNKP 67
P DTIRILITTDNHVGYNEND ITGDDSW+TFHE+M +AK+ NVDMV+Q GDLFHVNKP
Sbjct: 4 PDPDTIRILITTDNHVGYNENDPITGDDSWKTFHEVMMLAKNNNVDMVVQSGDLFHVNKP 63
Query: 68 SKKSMYQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISIPMFSISG 127
SKKS+YQV+K+LR CMGDKPCELELLSDP++ F + +F NVNYEDPN NISIP+F ISG
Sbjct: 64 SKKSLYQVLKTLRLCCMGDKPCELELLSDPSQVFHYDEFTNVNYEDPNFNISIPVFGISG 123
Query: 128 NHDDASGDGLLSPMDILQVSGLVNHFGKVPETDNIEITPLLLKKGNTRLALYGLASVRDE 187
NHDDASGD LL PMDIL +GL+NHFGKV E+D I++ PLL +KG+T+LALYGLA+VRDE
Sbjct: 124 NHDDASGDSLLCPMDILHATGLINHFGKVIESDKIKVVPLLFQKGSTKLALYGLAAVRDE 183
Query: 188 RLFRTFKEGKVRFNVPESQDDDWFNLMCVHQNHTGHTNTAFLPETFLPDFLNLVIWGHEH 247
RLFRTFK+G V F VP ++ +WFNLMCVHQNHTGHTNTAFLPE FLPDFL++VIWGHEH
Sbjct: 184 RLFRTFKDGGVTFEVPTMREGEWFNLMCVHQNHTGHTNTAFLPEQFLPDFLDMVIWGHEH 243
Query: 248 ECIPHLVHNPIKGFDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSLVPIPLKTVRP 307
ECIP+LVHNPIK FD+LQ GSSVATSLC+AE +PK+VF+L+I G P + PIPL+T+R
Sbjct: 244 ECIPNLVHNPIKNFDVLQPGSSVATSLCEAEAQPKYVFILDIKYGEAPKMTPIPLETIRT 303
Query: 308 FIMKDISLRDFPQLKPLDKDSINEFLYSKIEEMIKEALEKDTNITASEVDTEGVL----P 363
F MK ISL+D P L+P DKD+ +++L ++EEMI++A E+ A + + + V P
Sbjct: 304 FKMKSISLQDVPHLRPHDKDATSKYLIEQVEEMIRDANEETKQKLADDGEGDMVAELPKP 363
Query: 364 LVRLRVNYSGDIGSQ--VDYQVENPRRFSNRFVGRVANANNVVQFYKKKTPSASTRKK-- 419
L+RLRV+YS +Q +DYQVENPRRFSNRFVGRVAN NNVVQFYKK++P ++K
Sbjct: 364 LIRLRVDYSAPSNTQSPIDYQVENPRRFSNRFVGRVANGNNVVQFYKKRSPVTRSKKSGI 423
Query: 420 --IKFDPSDTALLSEQEDGDLQVQTLVNDFLNKMKLSLLPELGLNEAIRQFVDKDDKNAL 477
D L + G+L+VQTLVND LNKM+LSLLPE+GLNEA+++FVDKD+K AL
Sbjct: 424 NGTSISDRDVEKLFSESGGELEVQTLVNDLLNKMQLSLLPEVGLNEAVKKFVDKDEKTAL 483
Query: 478 KLFIDTEISHEVDILAQNKDVVNTEDVTNLKRLLKEVXXXXXXXXXXXXXXXXXXXXXIL 537
K FI EIS+EV IL+ N++ + T+D +K L+K+V
Sbjct: 484 KEFISHEISNEVGILSTNEEFLRTDDAEEMKALIKQVKRANSVRPTPPKENDETNFAFNG 543
Query: 538 PSLSIVHSEDDENYSHSDDSMATNETRKKNMRSRKTADTASNNGLPAPRRTRSVRKRTHV 597
L S + E + S D ++ + + A+++ P RT + +K
Sbjct: 544 NGLDSFRSSNREVRTGSPDITQSHVDNESRITHISQAESSKPTSKPKRVRTATKKKIPAF 603
Query: 598 DSDNEIDSSQSEVDEDKSAKNVESNGSDDVEFLDEPTSPTIRKIASDENEELAKSATRNK 657
I +++E+ ++ A+ DDV+ +DE I +++DE + K
Sbjct: 604 SDSTVISDAENELGDNNDAQ-------DDVD-IDE---NDIIMVSTDEEDASYGLLNGRK 652
Query: 658 STTKSRQQAKAKSNQR---SKSTRTPKTDALSELLARRSK 694
+ TK+R A K+ R +++RTPKTD L LLA++ K
Sbjct: 653 TKTKTRPAASTKTASRRGKGRASRTPKTDILGSLLAKKRK 692
>SPAC13C5.07 [L] KOG2310 DNA repair exonuclease MRE11
Length = 649
Score = 488 bits (1255), Expect = e-137
Identities = 271/662 (40%), Positives = 411/662 (61%), Gaps = 42/662 (6%)
Query: 5 NSLPAVDTIRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGDLFHV 64
N L +TIRILI++D HVGY E D + G+DS+ +F+EI+ +A++ +VDM++ GGD+FH
Sbjct: 10 NELHNENTIRILISSDPHVGYGEKDPVRGNDSFVSFNEILEIARERDVDMILLGGDIFHD 69
Query: 65 NKPSKKSMYQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISIPMFS 124
NKPS+K++YQ ++SLR C+GDKPCELELLSD + + N+NY DPN+N++IP+FS
Sbjct: 70 NKPSRKALYQALRSLRLNCLGDKPCELELLSDTSLTTGDTAVCNINYLDPNINVAIPVFS 129
Query: 125 ISGNHDDASGDGLLSPMDILQVSGLVNHFGKVPETDNIEITPLLLKKGNTRLALYGLASV 184
I GNHDD SGDG S +DILQV+GLVN+FG+VPE DNI ++P+LL+KG T+LALYG+++V
Sbjct: 130 IHGNHDDPSGDGRYSALDILQVTGLVNYFGRVPENDNIVVSPILLQKGFTKLALYGISNV 189
Query: 185 RDERLFRTFKEGKVRFNVPESQDDDWFNLMCVHQNHTGHTNTAFLPETFLPDFLNLVIWG 244
RDERL+ +F+E KV+F P+ D+WFNL+ VHQNH+ HT T++LPE+F+ DF + V+WG
Sbjct: 190 RDERLYHSFRENKVKFLRPDLYRDEWFNLLTVHQNHSAHTPTSYLPESFIQDFYDFVLWG 249
Query: 245 HEHECIPHLVHNPIKGFDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSLVPIPLKT 304
HEHEC+ +NP + F ++Q GS++ATSL ET PKH +L I+ G L I L+T
Sbjct: 250 HEHECLIDGSYNPTQKFTVVQPGSTIATSLSPGETAPKHCGILNIT-GKDFHLEKIRLRT 308
Query: 305 VRPFIMKDISLRDFPQLKPL--DKDSINEFLYSKIEEMIKEALEK--DTNITASEVDTE- 359
VRPFIMKDI L + + P+ +K + +L SK+EE I EA + + T V+ E
Sbjct: 309 VRPFIMKDIILSEVSSIPPMVENKKEVLTYLISKVEEAITEANAQWYEAQGTVPVVENEK 368
Query: 360 GVLPLVRLRVNYSGDIGSQVDYQVENPRRFSNRFVGRVANANNVVQFYKKKTPSASTRKK 419
LPL+RLRV+Y+G YQ ENP+RFSNRFVGRVANA +VVQFY KK + S R
Sbjct: 369 PPLPLIRLRVDYTG------GYQTENPQRFSNRFVGRVANATDVVQFYLKKKYTRSKRN- 421
Query: 420 IKFDPSDTALLSEQEDGDLQVQTLVNDFLNKMKLSLLPELGLNEAIRQFVDKDDKNALKL 479
D T+ + + + L+V++LVN++L +L LPE L EA+ FV+KDD++A+K
Sbjct: 422 ---DGLYTSAVEDIKINSLRVESLVNEYLKTNRLECLPEDSLGEAVVNFVEKDDRDAIKE 478
Query: 480 FIDTEISHEVDILAQNKDVVNT--EDVTNLKRLLKEVXXXXXXXXXXXXXXXXXXXXXIL 537
++T+++ ++++L + + ++++++ L ++ I
Sbjct: 479 CVETQLNKQINLLVKKRVTEENLEQEISSIINDLPKISTTKRKDYEELPEEVSETSINIA 538
Query: 538 PSLSIVHSEDDENYSHSDDSMATNETR----------KKNMRSRKTADTASNNGLPAPRR 587
++ HS + +++E KK + R+ + + P+R
Sbjct: 539 EHTPVLKHTSSLLDHHSPLATSSSEHEMEATPSPALLKKTNKRRELPSSLTKKNTRTPQR 598
Query: 588 TRSVRKRTHVDSDNEIDSSQSEVDEDKSAKNVESNGSDDVEFLDEPTSPTIRKIASDENE 647
++ V+K + + + KS KN +S + F D P+S T + +E++
Sbjct: 599 SKEVKK---------VPARKLSQSTKKSDKNTQST----LLFYD-PSSTTEAQYLDNEDD 644
Query: 648 EL 649
E+
Sbjct: 645 EI 646
>Hs5031921 [L] KOG2310 DNA repair exonuclease MRE11
Length = 680
Score = 393 bits (1009), Expect = e-109
Identities = 249/685 (36%), Positives = 379/685 (54%), Gaps = 59/685 (8%)
Query: 1 MEELNSLPAVDTIRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGD 60
M ++L +T +IL+ TD H+G+ E D G+D++ T EI+ +A++ VD ++ GGD
Sbjct: 1 MSTADALDDENTFKILVATDIHLGFMEKDAARGNDTFVTLDEILRLAQENEVDFILLGGD 60
Query: 61 LFHVNKPSKKSMYQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISI 120
LFH NKPS+K+++ ++ LR YCMGD+P + E+LSD + F FS FP VNY+D NLNISI
Sbjct: 61 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 120
Query: 121 PMFSISGNHDDASGDGLLSPMDILQVSGLVNHFGKVPETDNIEITPLLLKKGNTRLALYG 180
P+FSI GNHDD +G L +DIL +G VNHFG+ + I+I+P+LL+KG+T++ALYG
Sbjct: 121 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 180
Query: 181 LASVRDERLFRTFKEGKVRFNVPESQDDDWFNLMCVHQNHTGHTNTAFLPETFLPDFLNL 240
L S+ DERL+R F KV P+ ++ WFNL +HQN + H +T F+PE FL DF++L
Sbjct: 181 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 240
Query: 241 VIWGHEHECIPHLVHNPIKGFDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSLVPI 300
VIWGHEHEC N + F I Q GSSV TSL E KHV LL I KG K ++ I
Sbjct: 241 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRI-KGRKMNMHKI 299
Query: 301 PLKTVRPFIMKDISLRDFPQL----KPLDKDSINEFLYSKIEEMIKEALEKDTNITASEV 356
PL TVR F M+DI L + P + P +I F KIEEM++ A E++ + +
Sbjct: 300 PLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENA-ERERLGNSHQP 358
Query: 357 DTEGVLPLVRLRVNYSGDIGSQVDYQVENPRRFSNRFVGRVANANNVVQFYKKKTPSAST 416
+ PLVRLRV+YSG ++ + RFS +FV RVAN +++ F++ + T
Sbjct: 359 EK----PLVRLRVDYSG------GFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKT 408
Query: 417 RKKIKFDPSDTALLSEQEDG-DLQVQTLVNDFL----NKMKLSLLPELGLNEAIRQFVDK 471
++I F L+++ +G L+V+ LV + ++LSLL E G+ EA+++FVDK
Sbjct: 409 GEEINFG----KLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDK 464
Query: 472 DDKNALKLFIDTEI--------SHEVDILAQNKDVVNTEDVTNLKRLLKEVXXXXXXXXX 523
++K+A++ + ++ +D L D E+V + ++
Sbjct: 465 EEKDAIEELVKYQLEKTQRFLKERHIDALEDKID----EEVRRFRETRQKNTNEEDDEVR 520
Query: 524 XXXXXXXXXXXXILPSLSIVHSED-------DENYSHSDDSM--ATNE--TRKKNMRSRK 572
S S ++D ++ + SDDS+ ATN+ R + R +
Sbjct: 521 EAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGR 580
Query: 573 TADTASNNGLPAPRRTRSVRKRTHVDSDNEIDSSQSEVDEDKSAKNVESNGSDDVEFLDE 632
++AS G R +S R++ S N + SEV +E + SD E +
Sbjct: 581 GQNSASRGGSQRGRAFKSTRQQ---PSRNVTTKNYSEV--------IEVDESDVEEDIFP 629
Query: 633 PTSPTIRKIASDENEELAKSATRNK 657
TS T ++ +S + ++ + +K
Sbjct: 630 TTSKTDQRWSSTSSSKIMSQSQVSK 654
>Hs5031923 [L] KOG2310 DNA repair exonuclease MRE11
Length = 708
Score = 392 bits (1008), Expect = e-109
Identities = 250/702 (35%), Positives = 385/702 (54%), Gaps = 65/702 (9%)
Query: 1 MEELNSLPAVDTIRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGD 60
M ++L +T +IL+ TD H+G+ E D + G+D++ T EI+ +A++ VD ++ GGD
Sbjct: 1 MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGD 60
Query: 61 LFHVNKPSKKSMYQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISI 120
LFH NKPS+K+++ ++ LR YCMGD+P + E+LSD + F FS FP VNY+D NLNISI
Sbjct: 61 LFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISI 120
Query: 121 PMFSISGNHDDASGDGLLSPMDILQVSGLVNHFGKVPETDNIEITPLLLKKGNTRLALYG 180
P+FSI GNHDD +G L +DIL +G VNHFG+ + I+I+P+LL+KG+T++ALYG
Sbjct: 121 PVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYG 180
Query: 181 LASVRDERLFRTFKEGKVRFNVPESQDDDWFNLMCVHQNHTGHTNTAFLPETFLPDFLNL 240
L S+ DERL+R F KV P+ ++ WFNL +HQN + H +T F+PE FL DF++L
Sbjct: 181 LGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDL 240
Query: 241 VIWGHEHECIPHLVHNPIKGFDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSLVPI 300
VIWGHEHEC N + F I Q GSSV TSL E KHV LL I KG K ++ I
Sbjct: 241 VIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRI-KGRKMNMHKI 299
Query: 301 PLKTVRPFIMKDISLRDFPQL----KPLDKDSINEFLYSKIEEMIKEALEKDTNITASEV 356
PL TVR F M+DI L + P + P +I F KIEEM++ A E++ + +
Sbjct: 300 PLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENA-ERERLGNSHQP 358
Query: 357 DTEGVLPLVRLRVNYSGDIGSQVDYQVENPRRFSNRFVGRVANANNVVQFYKKKTPSAST 416
+ PLVRLRV+YSG ++ + RFS +FV RVAN +++ F++ + T
Sbjct: 359 EK----PLVRLRVDYSG------GFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKT 408
Query: 417 RKKIKFDPSDTALLSEQEDG-DLQVQTLVNDFL----NKMKLSLLPELGLNEAIRQFVDK 471
++I F L+++ +G L+V+ LV + ++LSLL E G+ EA+++FVDK
Sbjct: 409 GEEINFG----KLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDK 464
Query: 472 DDKNALKLFIDTEI--------SHEVDILAQNKDVVNTEDVTNLKRLLKEVXXXXXXXXX 523
++K+A++ + ++ +D L D E+V + ++
Sbjct: 465 EEKDAIEELVKYQLEKTQRFLKERHIDALEDKID----EEVRRFRETRQKNTNEEDDEVR 520
Query: 524 XXXXXXXXXXXXILPSLSIVHSED-------DENYSHSDDSM--ATNE--TRKKNMRSRK 572
S S ++D ++ + SDDS+ ATN+ R + R +
Sbjct: 521 EAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGR 580
Query: 573 TADTASNNGLPAPR-------RTRSVRKRTHVDSDNEID------SSQSEVDEDKSAKN- 618
++AS G R TRS +T V + + S++ + + + KN
Sbjct: 581 GQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNY 640
Query: 619 ---VESNGSDDVEFLDEPTSPTIRKIASDENEELAKSATRNK 657
+E + SD E + TS T ++ +S + ++ + +K
Sbjct: 641 SEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSK 682
>At5g54260 [L] KOG2310 DNA repair exonuclease MRE11
Length = 720
Score = 367 bits (941), Expect = e-101
Identities = 246/709 (34%), Positives = 373/709 (51%), Gaps = 54/709 (7%)
Query: 11 DTIRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGDLFHVNKPSKK 70
DT+R+L+ TD H+GY E D I DS++ F EI S+A++ VD ++ GGDLFH NKPS+
Sbjct: 8 DTLRVLVATDCHLGYMEKDEIRRHDSFKAFEEICSIAEEKQVDFLLLGGDLFHENKPSRT 67
Query: 71 SMYQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISIPMFSISGNHD 130
++ + I+ LR +C+ DKP + +++SD F+ + F VNYEDP+ N+ +P+FSI GNHD
Sbjct: 68 TLVKAIEILRRHCLNDKPVQFQVVSDQTVNFQ-NAFGQVNYEDPHFNVGLPVFSIHGNHD 126
Query: 131 DASGDGLLSPMDILQVSGLVNHFGKV----PETDNIEITPLLLKKGNTRLALYGLASVRD 186
D +G LS +DIL LVN+FGK+ I + P+L+KKG+T +ALYGL ++RD
Sbjct: 127 DPAGVDNLSAIDILSACNLVNYFGKMVLGGSGVGQITLYPILMKKGSTTVALYGLGNIRD 186
Query: 187 ERLFRTFK-EGKVRFNVPESQD----DDWFNLMCVHQNHTGHTNTAFLPETFLPDFLNLV 241
ERL R F+ V++ PE Q+ DWFN++ +HQN + E FLP FL+ +
Sbjct: 187 ERLNRMFQTPHAVQWMRPEVQEGCDVSDWFNILVLHQNRVKSNPKNAISEHFLPRFLDFI 246
Query: 242 IWGHEHECIPHLVHNPIKGFDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSLVPIP 301
+WGHEHEC+ GF I Q GSSVATSL D E+KPKHV LLEI KG++ IP
Sbjct: 247 VWGHEHECLIDPQEVSGMGFHITQPGSSVATSLIDGESKPKHVLLLEI-KGNQYRPTKIP 305
Query: 302 LKTVRPFIMKDISLRDFPQLKPLDKDSINEFLYSKIEEMIKEALEKDTNITASEVDTEGV 361
L +VRPF +I L+D + P D++SI E L + +I++A +K N SE+
Sbjct: 306 LTSVRPFEYTEIVLKDESDIDPNDQNSILEHLDKVVRNLIEKASKKAVN--RSEIK---- 359
Query: 362 LPLVRLRVNYSGDIGSQVDYQVENPRRFSNRFVGRVANANNVVQFYKKKTPSASTRKKIK 421
LPLVR++V+YSG + NP+RF ++VG+VAN +++ F K AS + + +
Sbjct: 360 LPLVRIKVDYSG-------FMTINPQRFGQKYVGKVANPQDILIFSK-----ASKKGRSE 407
Query: 422 FDPSDTALLSEQEDGDLQVQTLVNDFLNKMKLSLLPELGLNEAIRQFVDKDDKNALKLFI 481
+ D+ L +E ++ LV + + +K+ +LP L+ A+ FV+KDDK A +
Sbjct: 408 ANIDDSERLRPEELNQQNIEALVAE--SNLKMEILPVNDLDVALHNFVNKDDKLAFYSCV 465
Query: 482 DTEISHEVDILAQNKDVVNTEDVTNLKRLLKEVXXXXXXXXXXXXXXXXXXXXXILPSLS 541
+ LA++ D E+ + ++ + + +
Sbjct: 466 QYNLQETRGKLAKDSDAKKFEEDDLILKVGECLEERLKDRSTRPTGSSQFLSTGLTSENL 525
Query: 542 IVHSEDDENYSHSDDSMATNET----RKKNMRSRKTADTASNNGLPAPRRTR------SV 591
S N S SDD T + + R TA+T AP R R S
Sbjct: 526 TKGSSGIANASFSDDEDTTQMSGLAPPTRGRRGSSTANTTRGRA-KAPTRGRGRGKASSA 584
Query: 592 RKRTHVDSDNEIDSSQSEVDEDKSA--KNVESNGSDDVEFLDEPTSPTI------RKIAS 643
K+T +DS SQ SA K+ + G DDV D P+S + + +S
Sbjct: 585 MKQTTLDSSLGFRQSQRSASAAASAAFKSASTIGEDDV---DSPSSEEVEPEDFNKPDSS 641
Query: 644 DENEELAKSATRNKSTTKSRQQAKAKSNQRSKSTRTPKTDALSELLARR 692
E++E K R + T R + + S + + + +L+ LL+ +
Sbjct: 642 SEDDESTKGKGRKRPATTKRGRGRG-SGTSKRGRKNESSSSLNRLLSSK 689
>7297844 [L] KOG2310 DNA repair exonuclease MRE11
Length = 620
Score = 348 bits (893), Expect = 2e-95
Identities = 202/513 (39%), Positives = 302/513 (58%), Gaps = 38/513 (7%)
Query: 9 AVDTIRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGDLFHVNKPS 68
A + IRIL+ TDNH+GY E D + G+DS+ F EI+ +A +VDM++ GGDLFH PS
Sbjct: 11 ADNVIRILVATDNHLGYGEKDAVRGEDSFTAFEEILELAVSEDVDMILLGGDLFHDAVPS 70
Query: 69 KKSMYQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISIPMFSISGN 128
+ ++++ I+ LR Y GD+P LE+LSD +CF + +VNYEDPNLNI+IP+FSI GN
Sbjct: 71 QNALHKCIELLRRYTFGDRPVSLEILSDQGQCFHNAVNQSVNYEDPNLNIAIPVFSIHGN 130
Query: 129 HDDASGDGLLSPMDILQVSGLVNHFGKVPETDNIEITPLLLKKGNTRLALYGLASVRDER 188
HDD SG G LS +D+L SGLVN+FG+ + +EI+P+L++KG ++LALYGL+ + D R
Sbjct: 131 HDDPSGFGRLSSLDLLSTSGLVNYFGRWTDLTQVEISPVLMRKGESQLALYGLSHIHDGR 190
Query: 189 LFRTFKEGKVRFNVPES-----------QDDDWFNLMCVHQNHTGHTNTAFLPETFLPDF 237
L R K+ KV+FN PE+ +++DWF+L+ VHQN +LPE LP F
Sbjct: 191 LARLIKDFKVKFNCPENVANGEDGNESKEEEDWFHLLVVHQNRADRGPKNYLPEDLLPSF 250
Query: 238 LNLVIWGHEHECIPHLVHNPIKGFDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSL 297
L+LVIWGHEH+C N K F + Q GSSV TSL + E K KHV LLEI KG K L
Sbjct: 251 LHLVIWGHEHDCRIEPEENAKKRFYVSQPGSSVPTSLSEGEAKKKHVGLLEIYKG-KFKL 309
Query: 298 VPIPLKTVRPFIMKDISLRDF-PQLKPLDKDS---INEFLYSKIEEMIKEALEKDTNITA 353
P+PL+TVRPF+ + + L D +L ++ D+ + +F ++E MI+ A+ + T
Sbjct: 310 KPLPLETVRPFVYESVVLADHADELGLVEGDASTKVFKFAQERVEAMIERAVAQHTG--- 366
Query: 354 SEVDTEGVLPLVRLRVNYSGDIGSQVDYQVENPRRFSNRFVGRVANANNVVQFYKKKTPS 413
+ LPL+RLR+ Y+ + + N RF RVAN +VVQF K +
Sbjct: 367 --HPKQPTLPLIRLRLLYTD------ESCMFNAIRFGEMLSTRVANVQDVVQFSKVVKRT 418
Query: 414 ASTRKKIKFDPSDTALLSEQEDGDLQVQTLVNDFLNKMK----LSLLPELGLNEAIRQFV 469
+ + + AL + D +V+ LV+ + + K L L L E + +
Sbjct: 419 KTEAVNLDKEALRRAL---EADNATRVEELVDRYFEEAKSNKPLKLFHSKALAEMTYRLL 475
Query: 470 DKDD----KNALKLFIDTEISHEVDILAQNKDV 498
++ D +N +K + + + H ++ + ++++
Sbjct: 476 EQRDADAAENIVKFYKEKAVDHLMEAMPNDENI 508
>CE06573 [L] KOG2310 DNA repair exonuclease MRE11
Length = 772
Score = 310 bits (795), Expect = 4e-84
Identities = 195/510 (38%), Positives = 286/510 (55%), Gaps = 41/510 (8%)
Query: 11 DTIRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGDLFHVNKPSKK 70
D I+IL+ TD H GY EN D+ TF E++ +A + VDM++ GGDLFH N PS++
Sbjct: 108 DIIKILVATDIHCGYGENKANIHMDAVNTFEEVLQIATEQKVDMILLGGDLFHENNPSRE 167
Query: 71 SMYQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISIPMFSISGNHD 130
++V + LR YC+ P LE LSD + F S F +VNY D NLN+ +P+F+I GNHD
Sbjct: 168 VQHRVTQLLRQYCLNGNPIALEFLSDASVNFNQSVFGHVNYYDQNLNVGLPIFTIHGNHD 227
Query: 131 DASGDGLLSPMDILQVSGLVNHFGKVPETDNIEITPLLLKKGNTRLALYGLASVRDERLF 190
D SG G L+ +D+L SGLVN FGK ++P+LL+KG TRLALYG+ S RD+RL
Sbjct: 228 DLSGKG-LTALDLLHESGLVNLFGKHSNIQEFIVSPILLRKGETRLALYGIGSQRDDRLV 286
Query: 191 RTFKEGKVRFNVPESQDDDWFNLMCVHQN---HTGHTNTA-FLPETFLPDFLNLVIWGHE 246
R FK + F P + +DWFNL +HQN H +T FLPE+ +P F +L+IWGHE
Sbjct: 287 RAFKNNSISFLRPNAGAEDWFNLFVLHQNRPRRAMHRSTGNFLPESLIPQFFDLLIWGHE 346
Query: 247 HECIPHLVHNPIK-----GFDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSLVPIP 301
HEC P + GF ILQ GS+VATSL E K+ FL++I KG K + PIP
Sbjct: 347 HECKPDPQYVASSEAVGDGFYILQPGSTVATSLTPEEALQKNAFLIKI-KGRKFASKPIP 405
Query: 302 LKTVRPFIMKDISLRDFP----------QLKPLDKDSINEF-LYSKIEEMIKEALEKDTN 350
L+TVRP + ++ L P + K D I+E + +KI EMI T
Sbjct: 406 LQTVRPMVCDELLLDKIPPGSRPILKTDRPKHTDGRYIDEIAIEAKINEMI-------TT 458
Query: 351 ITASEVDTEGVLPLVRLRVNYSGDIGSQVDYQVENPRRFSNRFVGRVANANNVVQFYKKK 410
A + LPL+RL+V Y GD ++ N +R R+ VANA ++V F KK
Sbjct: 459 AKAKRRPRQPELPLIRLKVIYDGD---WLNITPANAKRIGLRYENVVANAVDMV-FIKKN 514
Query: 411 TPSASTRKKIKFDPSDTALLSEQ-EDGDLQVQTLVND-FLNKM---KLSLLPELGLNEAI 465
+ + + + + T + E + +QT++ND F+N+ ++++L +G+ A+
Sbjct: 515 NKPKEGKLQTENEKNITEMADEMGQVSATNLQTIINDYFINQPLVDQMTVLKPIGIGRAL 574
Query: 466 RQFVDKDD---KNALKLFIDTEISHEVDIL 492
Q+ ++ + D+ + H++D++
Sbjct: 575 EQYSAIEEGGLATSANRNFDSCLMHQIDVV 604
>ECU05g1280 [L] KOG2310 DNA repair exonuclease MRE11
Length = 567
Score = 268 bits (685), Expect = 2e-71
Identities = 177/532 (33%), Positives = 294/532 (54%), Gaps = 84/532 (15%)
Query: 13 IRILITTDNHVGYNENDTITGDDSWQTFHEIMSMAKDYNVDMVIQGGDLFHVNKPSKKSM 72
++ILIT+DNH+GY E+D + DDS+ TF EI+ +A+ VD+V+QGGDLFH N+PS+ +
Sbjct: 1 MKILITSDNHLGYRESDPVLLDDSYDTFEEILGIAQRERVDLVLQGGDLFHENRPSRSCL 60
Query: 73 YQVIKSLRTYCMGDKPCELELLSDPAECFRFSDFPNVNYEDPNLNISIPMFSISGNHDDA 132
+ I R YC+G++ L S+ A +N+ D N+ ISIP+ SI GNHDD
Sbjct: 61 NRTIGLFRRYCIGNERSGLR--SNLA----------LNFHDQNIGISIPVVSIHGNHDDP 108
Query: 133 SGDGLLSPMDILQVSGLVNHFGKVPETDNIEITPLLLKKGNTRLALYGLASVRDERLFRT 192
SG ++SP+DILQ +GLVN+ GK D I++ PLLL+K R+A+YGL ++D RL+R
Sbjct: 109 SGISMVSPIDILQSAGLVNYIGKYNLIDRIDVYPLLLEK-EYRVAIYGLGHIKDRRLYRM 167
Query: 193 FKEGKVRFNVPESQDDDWFNLMCVHQNHTGHTNTAFLPETFLPDFLNLVIWGHEHECIPH 252
F EG++ F+ PE D W+N++ +HQN F + + F +L+++GHEHE +
Sbjct: 168 FCEGRIVFHRPEDY-DSWYNVLILHQNRIPREKEHFSSD-LVEGFFDLIVYGHEHESM-- 223
Query: 253 LVHNPIKG-FDILQAGSSVATSLCDAETKPKHVFLLEISKGSKPSLVPIPLKTVRPFIMK 311
+KG ILQ GS+V TSLC+ E K+ ++L I G + +L + L++VRP ++
Sbjct: 224 ----VVKGDCLILQPGSTVRTSLCEGERHDKYAYILRI--GEECTLEHVKLRSVRPLLLD 277
Query: 312 DISLRDFPQLKPLDKDSINEFLYSKIEEMIKEALEKDT----NITASEVDTEGV------ 361
+ + ++D++ E + +KI MI +K++ ITA +VDT+
Sbjct: 278 TLRIE--------ERDNVEEKVENKIRGMIDLGRKKESLFNKEITAIDVDTKRFKCRGDS 329
Query: 362 --------------------LPLVRLRVNYSGDIGSQVDYQVENPRRFSNRFVGRVANAN 401
+PLV+L++ GD +V + RFS +F G VAN +
Sbjct: 330 NEACGAGPVCKGYQLEEKTRIPLVKLKIELCGD-------EVLDKHRFSAQFKGLVANPS 382
Query: 402 NVVQFYKKKTPSASTRKKIKFDPSDTALLSEQEDGDLQVQTLVNDFLNKMKLSLLPELGL 461
+++ T S TR++ + +T ++E+ +++ ++ L ++ +L LG
Sbjct: 383 DML------TISRKTRRR---EEVETQPMAER----VEISQILRKILGNVEFGVLSRLGF 429
Query: 462 NEAIRQFVDKDDKNALKLFIDTEISHEVDILAQNKDVVNTEDVTNLKRLLKE 513
+E++ +FV K D NA + I V+ + + +V+ + + +KR +E
Sbjct: 430 SESLDEFV-KGDSNAFMGMVRKNIEKVVNAV-DHSSIVDEDVIKAMKRASRE 479
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.132 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,186,881
Number of Sequences: 60738
Number of extensions: 1853486
Number of successful extensions: 7321
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 7270
Number of HSP's gapped (non-prelim): 8
length of query: 694
length of database: 30,389,216
effective HSP length: 113
effective length of query: 581
effective length of database: 23,525,822
effective search space: 13668502582
effective search space used: 13668502582
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)