ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1743 good H KOG4132 Coenzyme transport and metabolism Uroporphyrinogen III synthase UROS/HEM4
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1743 621740 620961 -260
(260 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR278w [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4 238 8e-63
SPAC31G5.08 [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4 125 5e-29
Hs4557873 [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4 72 1e-12
7290980 [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4 60 3e-09
>YOR278w [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4
Length = 275
Score = 238 bits (606), Expect = 8e-63
Identities = 133/269 (49%), Positives = 180/269 (66%), Gaps = 15/269 (5%)
Query: 3 KVILLKNKTVPSDPYEQKFAANGFLPIFVPLIRHFHLPEEALQLFKN-RQYLLSLKYIII 61
+V+LLKNKTVP D YE + + F PIFVPLI+H H+ ++ + YL ++ YIII
Sbjct: 8 RVLLLKNKTVPIDKYELECRSKAFEPIFVPLIKHTHVIQDFRNVLNTIPNYLNTINYIII 67
Query: 62 TSQRTVECLNESILPQLTPDEQNILKQKTIYTVGPATSAFLKKSGFLCIRGGVEVGNGAL 121
TSQRTVE LNE+I+P LT +++ L KT+YTVGPAT+ F+++SGF+ ++GG + GNG++
Sbjct: 68 TSQRTVESLNEAIIPTLTSEQKAALLSKTVYTVGPATANFIRRSGFINVKGGEDAGNGSI 127
Query: 122 LADLILQSHINE----SIDHFLFLVGEIRRDVIPNRLNSHGYKVNEVVTYRTENLEDNIG 177
LAD+I+ + LFLVGEIRRD+IP +L+S G KV EVVTY+TE L D
Sbjct: 128 LADIIIDDLSTDIKACPPSELLFLVGEIRRDIIPKKLHSKGIKVREVVTYKTEELSDGFK 187
Query: 178 TFV-ASCESNGDNVSTDRNNTWVVFFSPQGTEEIISFLKER---PG--YKFASIGPTTKQ 231
F+ A E + D V +D WVV FSPQGT+EI +L + PG + ASIGPTTK+
Sbjct: 188 RFIHAMKECDEDEVFSD----WVVVFSPQGTKEITQYLGDSNRLPGSHLRVASIGPTTKK 243
Query: 232 YLLEKGLVPDVVSNKPEPVSLFNAINNYK 260
YL + + DVVS KP+P SL +AI Y+
Sbjct: 244 YLDDNDVTSDVVSPKPDPKSLLDAIELYQ 272
>SPAC31G5.08 [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4
Length = 251
Score = 125 bits (315), Expect = 5e-29
Identities = 89/257 (34%), Positives = 135/257 (51%), Gaps = 16/257 (6%)
Query: 1 MSKVILLKNKTVPSDPYEQKFAANGFLPIFVPLIRHFHLPEEALQLFKNRQYLLSLKYII 60
M +LLK K+ P DPY + F G F+P++RH + EE L+ K + + +I
Sbjct: 1 MKTALLLKTKSQPFDPYVEAFEKYGRDTAFIPVLRHKRVHEEQLR-DKLKNVRKTYCGLI 59
Query: 61 ITSQRTVECLNESILPQLTPDEQNILKQKTIYTVGPATSAFLKKSGFLCIRGGVEVGNGA 120
+TSQR E L+E++ + + Q IL + I+TVGPAT +++ GF G + G G
Sbjct: 60 VTSQRVSETLDEALKQEDETERQKILMETPIFTVGPATDDSIRRLGFQQTH-GKDCGRGE 118
Query: 121 LLADLILQSH-INESIDHFLFLVGEIRRDVIPNRLNSHGYKVNEVVTYRTENLEDNIGTF 179
+LADLI + + + LFLVGE RD+I +L +V+ ++ Y T+ LE N T
Sbjct: 119 VLADLIEEWYTTTKQHKPLLFLVGEKHRDIIQRKLGDD--RVDSLIVYATQELE-NTETQ 175
Query: 180 VASCESNGDNVSTDRNNTWVVFFSPQGTEEIISFLKERPGYKFASIGPTTKQYLLEKGLV 239
+ D + W+V FSP +++ + K A+IGPTT YL + G
Sbjct: 176 IK------DTIRKHPTIDWIVAFSPTSICSLLNTFE----LKIATIGPTTGDYLKKLGTQ 225
Query: 240 PDVVSNKPEPVSLFNAI 256
P+VVS P P SL ++I
Sbjct: 226 PNVVSPAPNPESLASSI 242
>Hs4557873 [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4
Length = 265
Score = 71.6 bits (174), Expect = 1e-12
Identities = 75/273 (27%), Positives = 116/273 (42%), Gaps = 38/273 (13%)
Query: 3 KVILLKNKTVPS---DPYEQKFAANGFLPIFVPLI--RHFHLPEEALQLFKNRQYLLSLK 57
KV+LLK+ DPY ++ G +P++ LP + +L Y
Sbjct: 2 KVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDY----G 57
Query: 58 YIIITSQRTVECLNESILPQLTPDE--QNILKQK----TIYTVGPATSAFLKKSGFLCIR 111
+I TS R VE E L Q E + LK+K ++Y VG AT++ + K G
Sbjct: 58 GLIFTSPRAVEAA-ELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGL--DT 114
Query: 112 GGVEVGNGALLADLILQSHINESIDHFLFLVGEIRRDVIPNRLNSHGYKVNEVVTYRT-- 169
G GN LA+ I S LF G ++R+++P L G + + Y+T
Sbjct: 115 EGETCGNAEKLAEYICSRE--SSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVA 172
Query: 170 -ENLEDNIGTFVASCESNGDNVSTDRNNTWVVFFSPQGTEEIISFLKERPG-----YKFA 223
++ N+ ++ + G S + FFSP G + ++E G KFA
Sbjct: 173 HPGIQGNLNSYYSQ---QGVPAS-------ITFFSPSGLTYSLKHIQELSGDNIDQIKFA 222
Query: 224 SIGPTTKQYLLEKGLVPDVVSNKPEPVSLFNAI 256
+IGPTT + L +GL + P P +L I
Sbjct: 223 AIGPTTARALAAQGLPVSCTAESPTPQALATGI 255
>7290980 [H] KOG4132 Uroporphyrinogen III synthase UROS/HEM4
Length = 277
Score = 60.1 bits (144), Expect = 3e-09
Identities = 63/262 (24%), Positives = 103/262 (39%), Gaps = 21/262 (8%)
Query: 4 VILLKNKTVPSDPYEQKFAANGFLPIFVPLIRH-FHLPEEALQLFKNRQYLLSLKY--II 60
VI+ K+++ SD Y + + F P+FVP + F +E +N KY II
Sbjct: 8 VIIFKSESESSDVYAETLEKHDFNPVFVPTLSFGFKNLDELRAKLQNPD-----KYAGII 62
Query: 61 ITSQRTVECLNESILPQLTPDEQNILKQKTIYTVGPATSAFLKKSGFLCIRGGVEVGNGA 120
TS R VE + ES+ P +L Y VG T + G + GN
Sbjct: 63 FTSPRCVEAVAESLNLGELPGGWKMLHN---YAVGEVTHNLALSTLDQLFTHGKQTGNAR 119
Query: 121 LLADLILQSHINESIDHFLFLVGEIRRDVIPNRLNSHGYKVNEVVTYRTENLEDNIGTFV 180
L D I+ + L G + D + ++L +G+ V+ Y T +
Sbjct: 120 ALGDYIVDTFDGSRALPLLLPCGNLATDTLLSKLAENGFSVDACEVYETRCHPELGANVE 179
Query: 181 ASCESNGDNVSTDRNNTWVVFFSPQGTEEIISFLKER----PGYKFASIGPTTKQYLLEK 236
+ E G+++ ++ FFSP G + R +K +IGP+T++ L
Sbjct: 180 RALEIYGESIE------FLAFFSPSGVNCAQQYFTSRQLSMDKWKLVAIGPSTRRALESL 233
Query: 237 GLVPDVVSNKPEPVSLFNAINN 258
G + +P L + N
Sbjct: 234 GQKVYCTAERPTVEHLVKVLLN 255
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.138 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,296,978
Number of Sequences: 60738
Number of extensions: 707617
Number of successful extensions: 1584
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1574
Number of HSP's gapped (non-prelim): 4
length of query: 260
length of database: 30,389,216
effective HSP length: 104
effective length of query: 156
effective length of database: 24,072,464
effective search space: 3755304384
effective search space used: 3755304384
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)