ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1873 good B KOG4652 Chromatin structure and dynamics HORMA domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1873 666694 668436 581
(581 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YIL072w [B] KOG4652 HORMA domain 386 e-107
At1g67370 [B] KOG4652 HORMA domain 88 4e-17
Hs18549128 [B] KOG4652 HORMA domain 77 6e-14
Hs22068642 [B] KOG4652 HORMA domain 60 1e-08
At4g32200_1 [B] KOG4652 HORMA domain 57 8e-08
Hs22057577 [B] KOG4652 HORMA domain 51 6e-06
>YIL072w [B] KOG4652 HORMA domain
Length = 605
Score = 386 bits (992), Expect = e-107
Identities = 248/616 (40%), Positives = 348/616 (56%), Gaps = 46/616 (7%)
Query: 1 MSTIQKVREKNEVSTKNVISQDQSQKLVQTMITMCFGCLAFLRGLFPDDNFVDQKFVPEK 60
MS Q V+ K E TK I+ +QSQKL+QTM+TM FGCLAFLRGLFPDD FVDQ+FVPEK
Sbjct: 1 MSNKQLVKPKTE--TKTEITTEQSQKLLQTMLTMSFGCLAFLRGLFPDDIFVDQRFVPEK 58
Query: 61 CTKDYDKNSAS---SIRIKTLVRDKSDEANLFLDWLENGVFQTLRKGYLKAISLGVFIDE 117
K+Y+K + S SI+IKTL+R KS +A+L LDWLE GVF+++R LKA+SLG+F+++
Sbjct: 59 VEKNYNKQNTSQNNSIKIKTLIRGKSAQADLLLDWLEKGVFKSIRLKCLKALSLGIFLED 118
Query: 118 SNPNDLIETYLFSFDYSHDS-ITININGQADK------------VSLLDSRKMVQQLMRR 164
P DL+E Y+FSFDY ++ + IN+N +K +SLLDSR+MVQQLMRR
Sbjct: 119 --PTDLLENYIFSFDYDEENNVNINVNLSGNKKGSKNADPENETISLLDSRRMVQQLMRR 176
Query: 165 FIIITQSLDPLPEKRFLTMRLLFNDLAPKEYQPQLFKDATKDPKTIITVPQENGLDTFSV 224
FIIITQSL+PLP+K+FLTMRL+FND ++YQP+LFKDAT D + + VP D V
Sbjct: 177 FIIITQSLEPLPQKKFLTMRLMFNDNVDEDYQPELFKDATFDKRATLKVPTNLDNDAIDV 236
Query: 225 GSLNTSVHKVGIKVLSLADNTIQEQLASGITTQLDPFDLL---NDNIELPQDTPFNSQVN 281
G+LNT HKV + VLS A +++ E+ + ++DPFDL+ + +L + P Q
Sbjct: 237 GTLNTKHHKVALSVLSAATSSM-EKAGNTNFIRVDPFDLILQQQEENKLEESVPTKPQNF 295
Query: 282 EPSQTTTMLQKYLRSSPANFHPTQAIPGDLTLNQNDTNFQGTVSQKLKHIR-CLRCKKMV 340
SQTT +L L SS A+ PTQ + + V + ++ C C+K +
Sbjct: 296 VTSQTTNVLGNLLNSSQASIQPTQFVSNNPVTGICSCECGLEVPKAATVLKTCKSCRKTL 355
Query: 341 PAVCYGNHAGSSIPVCIECLNNNRIDMNSVTMQRFIMTRKIYRYMA-KKPDFPKSISEFY 399
+CYGN SSI C C+ +D Q +M RK++R++ KK FP SI+E
Sbjct: 356 HGICYGNFLHSSIEKCFTCIFGPSLDTKWSKFQDLMMIRKVFRFLVRKKKGFPASITELI 415
Query: 400 SIFYG-DSATDFDKQRIDDALSVLLMDEVFVVEPDVRVSSTGTQLRSSGYINVDSNSIFY 458
F + + K+R+ AL V +DE ++ + S T + SS + VD I
Sbjct: 416 DSFINVEDQNNEVKERVAFALFVFFLDETLCLDNGGKPSQTIRYVTSS--VLVDVKGIVI 473
Query: 459 P---KGTLPKGTCAWTFVLRASKARPFYTEPYAKTEAQLQKLLEQCENTFKNLKKLSVDD 515
P K W F + KA FY E + Q++ L+ N + + ++
Sbjct: 474 PNTRKQLNVNHEYKWHFTTSSPKAESFYQEVLPNSRKQVESWLQDITN-LRKVYSEALSP 532
Query: 516 SLTLHELSINDT--TNSMGYQGKSKKRVHSDNENDYISPEKSYLDTQNCHAD-------- 565
S TL EL +N + T G+ ++R D +Y+ +KS + A
Sbjct: 533 SSTLQELDLNSSLPTQDPIISGQKRRRYDLD---EYLEEDKSSVVNDTIKAKDFDESVPA 589
Query: 566 KVRRISVSKKTLKSAW 581
K+R+ISVSKKTLKS W
Sbjct: 590 KIRKISVSKKTLKSNW 605
>At1g67370 [B] KOG4652 HORMA domain
Length = 611
Score = 87.8 bits (216), Expect = 4e-17
Identities = 65/240 (27%), Positives = 122/240 (50%), Gaps = 33/240 (13%)
Query: 19 ISQDQSQKLVQTMITMCFGCLAFLRGLFPDDNFVDQKFVPEKCTKDYDKNSASSIRIKTL 78
I++ S L + ++ + ++++RGLFP+ F D K VP A ++IK L
Sbjct: 27 ITEQDSLLLTRNLLRIAIFNISYIRGLFPEKYFND-KSVP-----------ALDMKIKKL 74
Query: 79 VRDKSDEANLFLDWLENGVFQTLRKGYLKAISLGVFIDESNPNDLIETYLFSFDYS---H 135
+ ++ L +DW+E GV+ L++ YLK + I E+ +IE Y FSF YS
Sbjct: 75 MPMDAESRRL-IDWMEKGVYDALQRKYLKTLMFS--ICETVDGPMIEEYSFSFSYSDSDS 131
Query: 136 DSITININGQADK-----------VSLLDSRKMVQQLMRRFIIITQSLDPLPEKRFLTMR 184
+ +NIN +K ++ R +++R + + ++LD +P++R + M+
Sbjct: 132 QDVMMNINRTGNKKNGGIFNSTADITPNQMRSSACKMVRTLVQLMRTLDKMPDERTIVMK 191
Query: 185 LL-FNDLAPKEYQPQLFKDATKDPKTIITVPQENGLDTFSVGSLNTSVHKVGIKVLSLAD 243
LL ++D+ P +Y+P F+ T+D + +N L +G++N+ + +KV S+ D
Sbjct: 192 LLYYDDVTPPDYEPPFFRGCTEDEAQYVWT--KNPL-RMEIGNVNSKHLVLTLKVKSVLD 248
>Hs18549128 [B] KOG4652 HORMA domain
Length = 387
Score = 77.4 bits (189), Expect = 6e-14
Identities = 70/257 (27%), Positives = 128/257 (49%), Gaps = 45/257 (17%)
Query: 11 NEVSTKNVISQDQSQKLVQTMITMCFGCLAFLRGLFPDDNFVDQKFVPEKCTKDY--DKN 68
N++ST++ QS LV+ ++ + C+ +LRG+FP+ + +++ + C K DKN
Sbjct: 18 NKISTEH-----QSLVLVKRLLAVSVSCITYLRGIFPECAY-GTRYLDDLCVKILREDKN 71
Query: 69 SASSIRIKTLVRDKSDEANLFLDWLENGVFQTLRKGYLKAISLGVFIDESNPNDLIETYL 128
S ++ + W+ G + L+K Y V+ + +P + E Y
Sbjct: 72 CPGSTQL--------------VKWML-GCYDALQKKY-------VYTNPEDPQTISECYQ 109
Query: 129 FSFDYSHDSITINI--NGQADKVSLL--DSRKMVQQLMRRFIIITQSLDPLPEKRFLTMR 184
F F Y+++ ++ Q+++ S+L D++K L+R+ I+ Q+L PLP LTM+
Sbjct: 110 FKFKYTNNGPLMDFISKNQSNESSMLSTDTKKASILLIRKIYILMQNLGPLPNDVCLTMK 169
Query: 185 LLFND-LAPKEYQPQLFKDATKDPKTIITVPQENGLDTFSVGSLNTSVHKVGIKVLSLAD 243
L + D + P +YQP FKD D + +I + L +VG ++T H +KV
Sbjct: 170 LFYYDEVTPPDYQPPGFKDG--DCEGVIFEGEPMYL---NVGEVSTPFHIFKVKV----- 219
Query: 244 NTIQEQLASGITTQLDP 260
T +E++ + +T L P
Sbjct: 220 TTERERMENIDSTILSP 236
>Hs22068642 [B] KOG4652 HORMA domain
Length = 219
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/181 (25%), Positives = 80/181 (43%), Gaps = 21/181 (11%)
Query: 106 LKAISLGVFIDESNPNDLIETYLFSFDYSHDSITININGQADKVSLL------DSRKMVQ 159
L+ L ++ D + E Y F F Y+ + T++ + + S D +K
Sbjct: 11 LRMAVLTLYTDPMGSEKVTEMYQFKFKYTKEGATMDFDSHSSSTSFESGTNNEDIKKASV 70
Query: 160 QLMRRFIIITQSLDPLPEKRFLTMRL-LFNDLAPKEYQPQLFKDATKDPKTIITVPQENG 218
L+R+ I+ Q L+PLP LTM+L +N + P +YQP FK+ + N
Sbjct: 71 LLIRKLYILMQDLEPLPNNVVLTMKLHYYNAVTPHDYQPLGFKEGVNSHFLLFDKEPIN- 129
Query: 219 LDTFSVGSLNTSVHKVGIKVLS-------LADNTIQEQLASGITTQ---LDPFDLLNDNI 268
VG ++T H + +KV++ L +N +E + I Q D + ND+I
Sbjct: 130 ---VQVGFVSTGFHSMKVKVMTEATKVIDLENNLFRENSTTEIAHQGLDCDEEEECNDHI 186
Query: 269 E 269
+
Sbjct: 187 Q 187
>At4g32200_1 [B] KOG4652 HORMA domain
Length = 606
Score = 57.0 bits (136), Expect = 8e-08
Identities = 70/297 (23%), Positives = 121/297 (40%), Gaps = 73/297 (24%)
Query: 13 VSTKNVISQDQSQKLVQTMITMCFGCLAFLRGLFPDDNFVDQKFVPEKCTKDYDKNSASS 72
V +KN ++ QS L ++ ++++RGLFP F D VP A
Sbjct: 3 VVSKN--NEQQSLILTTELLRTAIFNISYIRGLFPVRYFKDMS-VP-----------ALD 48
Query: 73 IRIKTLVRDKSDEANLFLDWLENGVFQTLRKGYLKAISLGVFIDESNPNDLIETYLFSFD 132
+++K L+ ++ L + W+E GV+ L K +LK L +I E+ LIE Y+FSF
Sbjct: 49 LKMKKLMPMDAESRRL-IGWMEKGVYDALHKKHLK--KLIFYICETVDGPLIEEYIFSFS 105
Query: 133 YSHDS-----ITINING-------------------QADKVSLLDSRKMVQQLMRRFIII 168
YS + INI G +++S +D Q R +
Sbjct: 106 YSDSDSQDVRMNINITGINTYGGTLNSTADNSTADMTLNQMSSVD-EDFGQNARRSNAFV 164
Query: 169 TQSLDPL----------------PEKRFLTMRLLFNDLAPKEYQPQLFKDATKDPKTIIT 212
T + +R + M+LL+ + P +YQP F+ +++ +
Sbjct: 165 TYQRFSVYISFHIANYRLCYFFASVQRTILMKLLYYEYVPPDYQPPFFRGCSEEEEAQYV 224
Query: 213 VPQENGLDTFSVGSLNTSVHKVGIKVLSLADNTIQEQLASGITTQLDPFDLLNDNIE 269
P+ +G++N+ H + +KV S+ D DP + NDN++
Sbjct: 225 WPKIP--LRMEIGNVNSQHHVLTVKVKSVLD-------------PYDPCEDENDNMQ 266
>Hs22057577 [B] KOG4652 HORMA domain
Length = 204
Score = 50.8 bits (120), Expect = 6e-06
Identities = 40/158 (25%), Positives = 75/158 (47%), Gaps = 11/158 (6%)
Query: 111 LGVFIDESNPNDLIETYLFSFDYSHDSITINI--NGQADKVSLL--DSRKMVQQLMRRFI 166
L ++ + +P + E Y F F Y+++ ++ Q+++ S+L D+ K L+R+
Sbjct: 4 LAIYTNPEDPQTISECYQFKFKYTNNGPLMDFISESQSNESSMLCTDTEKASTLLIRKIY 63
Query: 167 IITQSLDPLPEKRFLTMRLLFNDLAPKEYQPQLFKDATKDPKTIITVPQENGLDTFSVGS 226
+ Q+L PLP R ++++ P +YQP FKD D + +I E L +VG
Sbjct: 64 TLMQNLGPLPNVCLSMKRFYYDEVTPPDYQPPGFKDG--DCEGVIF---EGELMYLNVGE 118
Query: 227 LNTSVHKVGIKVLSLADNTIQEQLASGITTQLDPFDLL 264
++T KV L + T + ++ T F ++
Sbjct: 119 VSTPFPT--FKVEQLVNKTSELDMSESKTRSGKSFRIM 154
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.133 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,560,915
Number of Sequences: 60738
Number of extensions: 1538794
Number of successful extensions: 4391
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4369
Number of HSP's gapped (non-prelim): 9
length of query: 581
length of database: 30,389,216
effective HSP length: 112
effective length of query: 469
effective length of database: 23,586,560
effective search space: 11062096640
effective search space used: 11062096640
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)