ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII1902 good T KOG0789 Signal transduction mechanisms Protein tyrosine phosphatase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII1902 676715 679663 983
(983 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YER075c [T] KOG0789 Protein tyrosine phosphatase 468 e-131
YOR208w [T] KOG0789 Protein tyrosine phosphatase 127 8e-29
Hs18375642 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 87 1e-16
Hs15619018 [T] KOG0789 Protein tyrosine phosphatase 87 1e-16
Hs18375652 [T] KOG0789 Protein tyrosine phosphatase 87 2e-16
Hs7706280 [T] KOG0789 Protein tyrosine phosphatase 86 4e-16
Hs18860898_2 [T] KOG0789 Protein tyrosine phosphatase 85 6e-16
CE02705 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and r... 84 8e-16
SPAC19D5.01 [T] KOG0789 Protein tyrosine phosphatase 83 2e-15
7294551 [T] KOG4228 Protein tyrosine phosphatase 82 3e-15
Hs18104993 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 80 2e-14
Hs18104991 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 80 2e-14
Hs18104989 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 80 2e-14
Hs22052020_2 [T] KOG0789 Protein tyrosine phosphatase 77 1e-13
CE15903 [T] KOG0789 Protein tyrosine phosphatase 74 9e-13
7301780 [T] KOG0789 Protein tyrosine phosphatase 74 1e-12
Hs4506323 [T] KOG0791 Protein tyrosine phosphatase contains fn3 ... 73 2e-12
Hs13677218 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 73 2e-12
Hs13677216 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 73 2e-12
Hs13677214 [T] KOG0791 Protein tyrosine phosphatase contains fn3... 73 2e-12
YDL230w [T] KOG0789 Protein tyrosine phosphatase 71 7e-12
Hs18860904 [T] KOG4228 Protein tyrosine phosphatase 71 9e-12
CE20481 [T] KOG0789 Protein tyrosine phosphatase 71 9e-12
SPAC11E3.09 [T] KOG0791 Protein tyrosine phosphatase contains fn... 70 2e-11
CE09981 [T] KOG0789 Protein tyrosine phosphatase 70 2e-11
Hs18641364 [T] KOG4228 Protein tyrosine phosphatase 67 1e-10
Hs18641362 [T] KOG4228 Protein tyrosine phosphatase 67 1e-10
Hs18641347 [T] KOG4228 Protein tyrosine phosphatase 67 1e-10
CE24794 [T] KOG4228 Protein tyrosine phosphatase 65 4e-10
Hs18375644 [T] KOG0790 Protein tyrosine phosphatase Corkscrew an... 65 5e-10
Hs19743914 [T] KOG0793 Protein tyrosine phosphatase 64 1e-09
Hs19743912 [T] KOG0793 Protein tyrosine phosphatase 64 1e-09
Hs11386149 [T] KOG0793 Protein tyrosine phosphatase 64 1e-09
CE28359 [T] KOG0789 Protein tyrosine phosphatase 59 5e-08
>YER075c [T] KOG0789 Protein tyrosine phosphatase
Length = 928
Score = 468 bits (1204), Expect = e-131
Identities = 325/975 (33%), Positives = 468/975 (47%), Gaps = 196/975 (20%)
Query: 104 PSASEP--SYSTCTPXXXXXXXXXXXXXXXXXXXXIAMKSNSLPAIPTICPKDLRFPKHK 161
P AS P SY T +P + +K + P +P+ PK+ R+ K +
Sbjct: 54 PKASSPLVSYKTSSP--------------------VLLKRATAPVLPSFKPKEQRYNKPQ 93
Query: 162 DCSFISPADLHHYIENMDQNPNEKLIIFDTRPFIEFNKNHIRSAMHLCLPSTLLKRKNFN 221
CS I+ +L IE + P+EK+++ D RPF E K+ I +++H+CLPSTLL+RKNF
Sbjct: 94 GCSLITAVELGKIIETL---PDEKVLLLDVRPFTEHAKSIITNSIHVCLPSTLLRRKNFT 150
Query: 222 LERLIGNLPSPGRETLSEYLLGSDSATANAKVVIYDNVANQTDYAVSLACFGISSKILDH 281
+L+ NL +P +++ L S A N +++IYD+ ANQT+ +VSL C+GI+SK+++
Sbjct: 151 FSKLLDNL-TPSEQSV----LKSKLAIDNLRIIIYDSTANQTESSVSLPCYGIASKLIEF 205
Query: 282 VSDKQKPSVFILAEGFESFNAAYPDDVEVGTMDLEDSYTLDSPSSPHQADNISPVQPQLK 341
++ +K +V IL GF F +PD + T + D + P SP N+
Sbjct: 206 DTNVKK-TVSILMCGFPQFKILFPDHINTNTFN-SDCISSAEPKSPKT--NLM----NSL 257
Query: 342 HSGRSHSHSCSPLKQP--------PQTGNXXXXXXXXX------------XXXXXXXXXX 381
H+ H + +PL P P
Sbjct: 258 HNTAPHMTATTPLSSPQMNLKLKVPDDSRSDHSNFSSSPSPRNVLSDSPMSSSSPISALF 317
Query: 382 XXKLPAPINNQHLPTFKLPQIEHDISDLDNYVKAVEINERSQRNSFLES-ENDLRSFKFP 440
+LPAP N + FK Q E +I L+ Y+ AV I E +R +S + L++F+FP
Sbjct: 318 KFQLPAPQTNIN-QMFKFSQNE-EIMGLETYLSAVNIKEEHERWYNNDSAKKSLQNFQFP 375
Query: 441 ASPSKXXXXXXXXXXXXXXXXXLSPADPSSGHNSSKLNFQVKYDNLYHRFASEEINQVVP 500
+ + N KL FQ++Y+NL + E I+ V+P
Sbjct: 376 KNQNSLEKDT----------------------NKDKLGFQIRYENLSKNYEKEVIDSVIP 413
Query: 501 SWFCQLMDIPKLHFISKFXXXXXXXXXXXXXXXG------------PSSSASIVSTQSRS 548
WF LM IPK+ +S+F PSS +++ S S
Sbjct: 414 EWFQHLMSIPKIELVSQFQKLDFLEKRRLNHSVSFRKKENSFILEKPSSYPEQLTSTSSS 473
Query: 549 TVAGN-----DRCVEDGHYDVD-------------EDDAEENLQSITISSGVEFGTKNRY 590
T+ ++ + H E D++ + ISSGVE G KNRY
Sbjct: 474 TIMPPKFPDVNKVQKRSHSQPIFTQYSKYKSMLSLESDSDSESDDVIISSGVELGAKNRY 533
Query: 591 KDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYINANY 650
KDIFPYEH+RV L S G ++ + + YINANY
Sbjct: 534 KDIFPYEHSRVILKKGLQSSKGIKHSHSTSDGG-----------------ILDNYINANY 576
Query: 651 LVNPFAQLQQSS-----TADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFE 705
L P ++Q+S T + VRYIATQAP+ T+ DFYTCILNN VP++L+LT++FE
Sbjct: 577 LSLPRFSVEQNSSFQTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFE 636
Query: 706 NGVEKCCNFWANGNYDGINVKLLDE------FSTMLQDKPMKAE-------------SNH 746
NG+EKC +W GNY+GI+VKLL++ +T ++ M + SN+
Sbjct: 637 NGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMGTQNSSLYSAGVQGNSSNY 696
Query: 747 EEDMFASKFWRHLKLNKTS-------------DXXXXXXXXXXXLSYNNDRSKFQLLQLQ 793
D + N ++ D L+Y++ ++LLQ+Q
Sbjct: 697 STDNDNDNDNNNNNNNNSNIPVTAAACDDDDDDDDDAILIRQILLTYHDQEKPYELLQIQ 756
Query: 794 IKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTLCT 853
+K+WPDLGTLL P ILQ IN+KN +ID+LFA N Y + PT+LVHCSAGCGRTGTLCT
Sbjct: 757 VKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCT 816
Query: 854 VDSILSNLKKFDTDENPSLYGAFAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTVNQ 913
+DSILSN + F+ F K P L FDPI T+N
Sbjct: 817 IDSILSNFEMFE----------------------MLQKEFVKLKYPAKL-FDPISWTINI 853
Query: 914 FRRQRISMVQNINQFLFIYDCLLFYFTLNLE--TSPTDPEKRN----NWQSMTDENSHLD 967
FR++RISMVQNINQF+FIYDCLLFYF L L+ T TD + N + ++ ++ L+
Sbjct: 854 FRKERISMVQNINQFIFIYDCLLFYFRLRLDDITERTDGDGSNKDNISLSALIEQIEKLE 913
Query: 968 ILHKFIDGKVNELQQ 982
IL F+D K+ EL Q
Sbjct: 914 ILQTFVDDKLKELPQ 928
>YOR208w [T] KOG0789 Protein tyrosine phosphatase
Length = 750
Score = 127 bits (319), Expect = 8e-29
Identities = 117/411 (28%), Positives = 171/411 (41%), Gaps = 95/411 (23%)
Query: 566 EDDAEENLQSITISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXX 625
+D + ++ G++ TKNRY +I PYEH+RVKL HS A E
Sbjct: 390 DDTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSEASTTETKTDKS 449
Query: 626 XXXXXGLPTQDEQEDVW-NTYINANYL----VNPFAQLQQSSTADIKSVRYIATQAPLKE 680
P + N YINANYL +NP +YIATQAPL
Sbjct: 450 YPM---CPVDAKNHSCKPNDYINANYLKLTQINP-------------DFKYIATQAPLPS 493
Query: 681 TISDFYTCILNNNVPIILTLTDEFENGVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPM 740
T+ DF+ I N V +I++L + E + K +W N +Y +KL + + +
Sbjct: 494 TMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICN---- 549
Query: 741 KAESNHEEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYNNDRSK--------FQLLQL 792
R ++ KT+ L +N D + F + QL
Sbjct: 550 ----------INGCVLRVFQVKKTAP-QNDNISQDCDLPHNGDLTSITMAVSEPFIVYQL 598
Query: 793 QIKDWPDLGTLLKPNEILQIINLKNFVI---------------------DSLFAHNVYSP 831
Q K+W D + N+I+++ +KN ++ D+ ++ +
Sbjct: 599 QYKNWLD-SCGVDMNDIIKLHKVKNSLLFNPQSFITSLEKDVCKPDLIDDNNSELHLDTA 657
Query: 832 NYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSPTTK-S 890
N +P +LVHCSAGCGRTG T+D +LS LSPTT S
Sbjct: 658 NSSP-LLVHCSAGCGRTGVFVTLDFLLS-----------------------ILSPTTNHS 693
Query: 891 NSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLLFYFTL 941
N L+F VN+ R+QRISMVQN+ Q++ Y+ LL YF L
Sbjct: 694 NKIDVWNMTQDLIF----IIVNELRKQRISMVQNLTQYIACYEALLNYFAL 740
>Hs18375642 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 593
Score = 87.0 bits (214), Expect = 1e-16
Identities = 95/385 (24%), Positives = 143/385 (36%), Gaps = 113/385 (29%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYK+I P++HTRV L D E V + YI
Sbjct: 276 KNRYKNILPFDHTRVVLHDG-----------------------------DPNEPV-SDYI 305
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NAN ++ F + + +++ KS YIATQ L+ T++DF+ + N +I+ T E E
Sbjct: 306 NANIIMPEF-ETKCNNSKPKKS--YIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER 362
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G KC +W DE++ L++ + N +E R LKL+K
Sbjct: 363 GKSKCVKYWP------------DEYA--LKEYGVMRVRNVKESAAHDYTLRELKLSKVGQ 408
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAH 826
N +R+ + Q + WPD G P +L + + H
Sbjct: 409 G-------------NTERT---VWQYHFRTWPDHGVPSDPGGVLDFLEEVH--------H 444
Query: 827 NVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSP 886
S V+VHCSAG GRTGT +D ++ +++ D +
Sbjct: 445 KQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDID--------------- 489
Query: 887 TTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLLFYF-TLNLET 945
+ T+ R QR MVQ Q+ FIY + Y TL
Sbjct: 490 --------------------VPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRI 529
Query: 946 SPTDPEKRNNWQ------SMTDENS 964
KR + S+ D+ S
Sbjct: 530 EEEQKRKRKGHEYTNIKYSLADQTS 554
>Hs15619018 [T] KOG0789 Protein tyrosine phosphatase
Length = 691
Score = 87.0 bits (214), Expect = 1e-16
Identities = 89/368 (24%), Positives = 137/368 (37%), Gaps = 119/368 (32%)
Query: 577 TISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQD 636
T++ + KNRYKDI PY+++RV+LS L T D
Sbjct: 47 TVAENAKNIKKNRYKDILPYDYSRVELS---------------------------LITSD 79
Query: 637 EQEDVWNTYINANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPI 696
E ++YINAN++ + YIATQ PL T+ DF+ I +V I
Sbjct: 80 ED----SSYINANFIKGVYGPKA-----------YIATQGPLSTTLLDFWRMIWEYSVLI 124
Query: 697 ILTLTDEFENGVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFW 756
I+ E+E G +KC +WA + L+ P S E +
Sbjct: 125 IVMACMEYEMGKKKCERYWA------------EPGEMQLEFGPFSV-SCEAEKRKSDYII 171
Query: 757 RHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLK 816
R LK+ S+ + Q K+WPD P+ I I+ L
Sbjct: 172 RTLKVKFNSETRT-------------------IYQFHYKNWPDHDV---PSSIDPILEL- 208
Query: 817 NFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAF 876
++ Y + + + +HCSAGCGRTG +C +D LK EN S++
Sbjct: 209 ------IWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVF--- 259
Query: 877 AVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLL 936
+ + + R QR S+VQ Q+ +Y+ +L
Sbjct: 260 --------------------------------SLIREMRTQRPSLVQTQEQYELVYNAVL 287
Query: 937 FYFTLNLE 944
F ++
Sbjct: 288 ELFKRQMD 295
>Hs18375652 [T] KOG0789 Protein tyrosine phosphatase
Length = 780
Score = 86.7 bits (213), Expect = 2e-16
Identities = 77/276 (27%), Positives = 106/276 (37%), Gaps = 84/276 (30%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYKDI P++H+RVKL+ + P+QD YI
Sbjct: 61 KNRYKDILPFDHSRVKLTLKT-------------------------PSQDSD------YI 89
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NAN++ + Y+ATQ PL T+ DF+ I NV II+ EFE
Sbjct: 90 NANFIKGVYGPKA-----------YVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM 138
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G +KC +W D I P K S +E F R L
Sbjct: 139 GRKKCERYWPLYGEDPITF------------APFKI-SCEDEQARTDYFIRTL------- 178
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAH 826
L + N+ + L Q +WPD + IL +I+L
Sbjct: 179 ----------LLEFQNESRR--LYQFHYVNWPDHDVPSSFDSILDMISLM---------- 216
Query: 827 NVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLK 862
Y + + +HCSAGCGRTG +C +D + LK
Sbjct: 217 RKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLK 252
>Hs7706280 [T] KOG0789 Protein tyrosine phosphatase
Length = 807
Score = 85.5 bits (210), Expect = 4e-16
Identities = 89/358 (24%), Positives = 134/358 (36%), Gaps = 119/358 (33%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYKDI PY+++RV+LS L T DE ++YI
Sbjct: 57 KNRYKDILPYDYSRVELS---------------------------LITSDED----SSYI 85
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NAN++ + YIATQ PL T+ DF+ I +V II E+E
Sbjct: 86 NANFIKGVYGPKA-----------YIATQGPLSTTLLDFWRMIWEYSVLIIGMACMEYEM 134
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G +KC +WA V++ EF + S E + R LK+ S+
Sbjct: 135 GKKKCERYWAE------PVEMQLEFGPF-------SVSCEAEKRKSDYIIRTLKVKFNSE 181
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAH 826
+ Q K+WPD P+ I I+ L ++
Sbjct: 182 TRT-------------------IYQFHYKNWPDHDV---PSSIDPILEL-------IWDV 212
Query: 827 NVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSP 886
Y + + + +HCSAGCGRTG +C +D LK EN S++
Sbjct: 213 RCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVF------------- 259
Query: 887 TTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLLFYFTLNLE 944
+ + + R QR S+VQ Q+ +Y+ +L F ++
Sbjct: 260 ----------------------SLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD 295
>Hs18860898_2 [T] KOG0789 Protein tyrosine phosphatase
Length = 745
Score = 84.7 bits (208), Expect = 6e-16
Identities = 100/385 (25%), Positives = 140/385 (35%), Gaps = 127/385 (32%)
Query: 555 RCVEDGHYDVDEDDAEENLQSITISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCE 614
RC D + + + EN KNRY +I Y+H+RVKL
Sbjct: 157 RCTADMNITAEHSNHPENKH------------KNRYINILAYDHSRVKLRP--------- 195
Query: 615 NXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYINANYLVNPFAQLQQSSTADIKSVRYIAT 674
LP +D + + YINANY+ K+ YIAT
Sbjct: 196 -----------------LPGKDSKH---SDYINANYV-----------DGYNKAKAYIAT 224
Query: 675 QAPLKETISDFYTCILNNNVPIILTLTDEFENGVEKCCNFWANGN---YDGINVKLLDEF 731
Q PLK T DF+ I N II+ +T+ E G KC +W N Y I V L
Sbjct: 225 QGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTL---- 280
Query: 732 STMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQ 791
K K + + F+ R+ K+ K + +++ ++Q
Sbjct: 281 ------KSTKIHACYTVRRFSI---RNTKVKKGQKG-----------NPKGRQNERVVIQ 320
Query: 792 LQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTL 851
WPD+G P L ++ FV S A P P VLVHCSAG GRTGT
Sbjct: 321 YHYTQWPDMGV---PEYALPVL---TFVRRSSAAR---MPETGP-VLVHCSAGVGRTGTY 370
Query: 852 CTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTV 911
+DS+L +K T ++ +
Sbjct: 371 IVIDSMLQQIKDKSTVN--------------------------------------VLGFL 392
Query: 912 NQFRRQRISMVQNINQFLFIYDCLL 936
R QR +VQ Q++FI+D LL
Sbjct: 393 KHIRTQRNYLVQTEEQYIFIHDALL 417
>CE02705 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 668
Score = 84.3 bits (207), Expect = 8e-16
Identities = 91/363 (25%), Positives = 139/363 (38%), Gaps = 80/363 (22%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYK+I P++HTRV L+ D + YI
Sbjct: 295 KNRYKNIVPFDHTRVILT-------------------------------DRPNTPGSDYI 323
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NA+Y+ +Q ++ T + +IATQ L+ TISDF++ + N +I+ T E E
Sbjct: 324 NASYVRFENSQRTKNVTFACEK-SFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER 382
Query: 707 GVEKCCNFW-ANGNYDGIN--VKLLDEFSTMLQ---DKPMKAESNHEE-DMFASKFWRHL 759
EKC +W A N ++ + L +Q +KAE E+ + A
Sbjct: 383 K-EKCARYWPAEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRIAKGLVPEA 441
Query: 760 KLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFV 819
+LN L + ++ QLQ WPD G L P +L + +
Sbjct: 442 ELNGDG-----ISYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDRE 496
Query: 820 IDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVP 879
D A + + ++VHCSAG GRTGT+ +D++L+ +KK P
Sbjct: 497 YDYFNAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKV----------GLLCP 546
Query: 880 LTPNLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLLFYF 939
+ + V R R +VQ Q+ F+Y L FY
Sbjct: 547 M-------------------------DVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYL 581
Query: 940 TLN 942
N
Sbjct: 582 KNN 584
>SPAC19D5.01 [T] KOG0789 Protein tyrosine phosphatase
Length = 711
Score = 82.8 bits (203), Expect = 2e-15
Identities = 94/378 (24%), Positives = 137/378 (35%), Gaps = 136/378 (35%)
Query: 567 DDAEENLQSITISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXX 626
+D++ + + S KNRY DI PY+ TRV+L+ CS
Sbjct: 441 NDSKSDWCCLASSRSTSISRKNRYTDIVPYDKTRVRLAVPKGCS---------------- 484
Query: 627 XXXXGLPTQDEQEDVWNTYINANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFY 686
YINA+++ D+ + +YIA QAP T+ DF+
Sbjct: 485 -----------------DYINASHI-------------DVGNKKYIACQAPKPGTLLDFW 514
Query: 687 TCILNNNVP--IILTLTDEFENGVEKCCNFWANGNYDG--------INVKLLDEFSTMLQ 736
+ +N+ +I+ LT+ +E G EKC +W + I+V+ + F +
Sbjct: 515 EMVWHNSGTNGVIVMLTNLYEAGSEKCSQYWPDNKDHALCLEGGLRISVQKYETFEDLKV 574
Query: 737 DKPM-KAESNHEEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIK 795
+ + + + + + FW H +KT
Sbjct: 575 NTHLFRLDKPNGPPKYIHHFWVHTWFDKTH------------------------------ 604
Query: 796 DWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVD 855
PD+ I II ID + PN P + VHCSAG GRTGT VD
Sbjct: 605 --PDI------ESITGIIRC----IDKV-------PNDGP-MFVHCSAGVGRTGTFIAVD 644
Query: 856 SILSNLKKFDTDENPSLYGAFAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFR 915
IL K +P T NL + D I VN R
Sbjct: 645 QILQVPKNI-------------LPKTTNLEDSK----------------DFIFNCVNSLR 675
Query: 916 RQRISMVQNINQFLFIYD 933
QR+ MVQN QF F+YD
Sbjct: 676 SQRMKMVQNFEQFKFLYD 693
>7294551 [T] KOG4228 Protein tyrosine phosphatase
Length = 1428
Score = 82.4 bits (202), Expect = 3e-15
Identities = 88/354 (24%), Positives = 131/354 (36%), Gaps = 115/354 (32%)
Query: 583 EFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVW 642
E KNRY DI Y+ TRVKL+ GL T D
Sbjct: 882 ENACKNRYPDIKAYDQTRVKLA-----------------------VINGLQTTD------ 912
Query: 643 NTYINANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTD 702
YINAN+++ + ++I Q P++ TI DF+ I ++ II+ LT+
Sbjct: 913 --YINANFVIGYKERK-----------KFICAQGPMESTIDDFWRMIWEQHLEIIVMLTN 959
Query: 703 EFENGVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLN 762
E KC +W +D +F +L KF + K
Sbjct: 960 LEEYNKAKCAKYWPEKVFD------TKQFGDIL-----------------VKFAQERKTG 996
Query: 763 KTSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDS 822
+ + DR Q+ Q W D P+ I++ I N
Sbjct: 997 DYIERTLNVSKNKANVGEEEDRR--QITQYHYLTWKDFMAPEHPHGIIKFIRQIN----- 1049
Query: 823 LFAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTP 882
+VYS P +LVHCSAG GRTGTL +DS++ L++ +++ S+Y
Sbjct: 1050 ----SVYSLQRGP-ILVHCSAGVGRTGTLVALDSLIQQLEE---EDSVSIY--------- 1092
Query: 883 NLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLL 936
TV R QR +VQ++ Q++F+Y LL
Sbjct: 1093 --------------------------NTVCDLRHQRNFLVQSLKQYIFLYRALL 1120
>Hs18104993 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 624
Score = 79.7 bits (195), Expect = 2e-14
Identities = 88/348 (25%), Positives = 126/348 (35%), Gaps = 113/348 (32%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYK+I P++H+RV L +P D YI
Sbjct: 273 KNRYKNILPFDHSRVILQGRD----------------------SNIPGSD--------YI 302
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NANY+ N Q D + YIA+Q L+ T++DF+ N +I+ T E E
Sbjct: 303 NANYIKN------QLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK 356
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G KC +W E P + E D K R L+++
Sbjct: 357 GRNKCVPYW-------------PEVGMQRAYGPYSVTNCGEHDTTEYKL-RTLQVSPLD- 401
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAH 826
N D + ++ Q WPD G +P +L ++ N +SL
Sbjct: 402 --------------NGDLIR-EIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL--- 443
Query: 827 NVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNL--KKFDTDENPSLYGAFAVPLTPNL 884
P+ P ++VHCSAG GRTGT+ +D ++ N+ K D D +
Sbjct: 444 ----PHAGP-IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID--------------- 483
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIY 932
I T+ R QR MVQ Q+ FIY
Sbjct: 484 ----------------------IQKTIQMVRAQRSGMVQTEAQYKFIY 509
>Hs18104991 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 597
Score = 79.7 bits (195), Expect = 2e-14
Identities = 88/348 (25%), Positives = 126/348 (35%), Gaps = 113/348 (32%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYK+I P++H+RV L +P D YI
Sbjct: 275 KNRYKNILPFDHSRVILQGRD----------------------SNIPGSD--------YI 304
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NANY+ N Q D + YIA+Q L+ T++DF+ N +I+ T E E
Sbjct: 305 NANYIKN------QLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK 358
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G KC +W E P + E D K R L+++
Sbjct: 359 GRNKCVPYW-------------PEVGMQRAYGPYSVTNCGEHDTTEYKL-RTLQVSPLD- 403
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAH 826
N D + ++ Q WPD G +P +L ++ N +SL
Sbjct: 404 --------------NGDLIR-EIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL--- 445
Query: 827 NVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNL--KKFDTDENPSLYGAFAVPLTPNL 884
P+ P ++VHCSAG GRTGT+ +D ++ N+ K D D +
Sbjct: 446 ----PHAGP-IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID--------------- 485
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIY 932
I T+ R QR MVQ Q+ FIY
Sbjct: 486 ----------------------IQKTIQMVRAQRSGMVQTEAQYKFIY 511
>Hs18104989 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 595
Score = 79.7 bits (195), Expect = 2e-14
Identities = 88/348 (25%), Positives = 126/348 (35%), Gaps = 113/348 (32%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYK+I P++H+RV L +P D YI
Sbjct: 273 KNRYKNILPFDHSRVILQGRD----------------------SNIPGSD--------YI 302
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NANY+ N Q D + YIA+Q L+ T++DF+ N +I+ T E E
Sbjct: 303 NANYIKN------QLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK 356
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G KC +W E P + E D K R L+++
Sbjct: 357 GRNKCVPYW-------------PEVGMQRAYGPYSVTNCGEHDTTEYKL-RTLQVSPLD- 401
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAH 826
N D + ++ Q WPD G +P +L ++ N +SL
Sbjct: 402 --------------NGDLIR-EIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESL--- 443
Query: 827 NVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNL--KKFDTDENPSLYGAFAVPLTPNL 884
P+ P ++VHCSAG GRTGT+ +D ++ N+ K D D +
Sbjct: 444 ----PHAGP-IIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDID--------------- 483
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIY 932
I T+ R QR MVQ Q+ FIY
Sbjct: 484 ----------------------IQKTIQMVRAQRSGMVQTEAQYKFIY 509
>Hs22052020_2 [T] KOG0789 Protein tyrosine phosphatase
Length = 307
Score = 77.0 bits (188), Expect = 1e-13
Identities = 83/350 (23%), Positives = 123/350 (34%), Gaps = 125/350 (35%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRY+DI PY+ TRV L S YI
Sbjct: 73 KNRYRDILPYDSTRVPLGKSK------------------------------------DYI 96
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NA+Y+ ++ + YIATQ PL TI DF+ +L NN +I +T E E
Sbjct: 97 NASYI-----RIVNCG----EEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEG 147
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G+ KC ++W + +K F L++ + F + ++ ++
Sbjct: 148 GIIKCYHYWPISLKKPLELK---HFRVFLENYQIL-------QYFIIRMFQVVE------ 191
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAH 826
+ + + QLQ WPD GT + ++ I
Sbjct: 192 --------------KSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYAR--------- 228
Query: 827 NVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSP 886
+ T ++VHCSAG GRTG VD + +
Sbjct: 229 ---KSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAI------------------------- 260
Query: 887 TTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLL 936
K+ SF+ I+ V Q R QR MVQ Q+ F YD +L
Sbjct: 261 -VKNCSFN------------IMDIVAQMREQRSGMVQTKEQYHFCYDIVL 297
>CE15903 [T] KOG0789 Protein tyrosine phosphatase
Length = 490
Score = 74.3 bits (181), Expect = 9e-13
Identities = 71/269 (26%), Positives = 98/269 (36%), Gaps = 75/269 (27%)
Query: 671 YIATQAPLKETISDFYTCILNNNVPIILTLTDEFENGVEKCCNFWANGNYDGINVKLLDE 730
YI TQ PL ET+SDF+ I + +L L FE GVEKC ++ G VK
Sbjct: 245 YITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKL--GEVVKFGKY 302
Query: 731 FSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLL 790
T+ + K E+ A W L + T D +
Sbjct: 303 EITLTECK---------EEAIAGTIWNALTVTNTEDASS---------------EPLYMN 338
Query: 791 QLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGT 850
+Q+ WPD L P + +I L +V +P TP + VHCSAG GRT T
Sbjct: 339 HVQVPWWPD---QLAPEDARPMIELYKWV-------KKVNPKETP-ICVHCSAGVGRTAT 387
Query: 851 LCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTT 910
+D Y + PN+ ++
Sbjct: 388 FVGID-----------------YATIRIMENPNIE---------------------MLDI 409
Query: 911 VNQFRRQRISMVQNINQFLFIYDCLLFYF 939
V + R R VQ+ QFLF+Y L+ YF
Sbjct: 410 VREMRAMRFQAVQSHMQFLFLYVVLMEYF 438
>7301780 [T] KOG0789 Protein tyrosine phosphatase
Length = 1285
Score = 73.6 bits (179), Expect = 1e-12
Identities = 76/280 (27%), Positives = 111/280 (39%), Gaps = 83/280 (29%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRY +I Y+H+RV L PT +++++ YI
Sbjct: 493 KNRYLNITAYDHSRVHLH----------------------------PTPGQKKNL--DYI 522
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NAN++ K +I TQ PL +T F+ I V II+ +T+ E
Sbjct: 523 NANFI-----------DGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVER 571
Query: 707 GVEKCCNFWANG---NYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNK 763
G KC +W Y I VKL++E + S + K HLKL K
Sbjct: 572 GRRKCDMYWPKDGVETYGVIQVKLIEE----------EVMSTYTVRTLQIK---HLKLKK 618
Query: 764 TSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSL 823
N ++ + Q +WPD GT P +L NFV S
Sbjct: 619 KK-------------QCNTEKLVY---QYHYTNWPDHGTPDHPLPVL------NFVKKSS 656
Query: 824 FAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKK 863
A +P ++VHCSAG GRTGT +D++L +++
Sbjct: 657 AA----NPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQ 692
>Hs4506323 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1188
Score = 73.2 bits (178), Expect = 2e-12
Identities = 82/351 (23%), Positives = 126/351 (35%), Gaps = 125/351 (35%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRY +I PY+ +RV+L + +E+E YI
Sbjct: 937 KNRYTNILPYDFSRVRLV-----------------------------SMNEEEGA--DYI 965
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NANY+ P Q YIATQ PL ET +DF+ +L II+ LT E
Sbjct: 966 NANYI--PGYNSPQE---------YIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
KC ++W E D ++ S E+D +A RH ++N +
Sbjct: 1015 RRVKCDHYWP-----------FTEEPIAYGDITVEMISEEEQDDWAC---RHFRINYADE 1060
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLG--TLLKPNEILQIINLKNFVIDSLF 824
++ WPD G T ILQ +++
Sbjct: 1061 MQ-------------------DVMHFNYTAWPDHGVPTANAAESILQFVHMV-------- 1093
Query: 825 AHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNL 884
+ +++HCSAG GRTGT +D +L +++ +
Sbjct: 1094 --RQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE------------------- 1132
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCL 935
F I+ V++ R R+SMVQ Q++FI+ C+
Sbjct: 1133 -------------------FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
>Hs13677218 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 405
Score = 73.2 bits (178), Expect = 2e-12
Identities = 82/351 (23%), Positives = 126/351 (35%), Gaps = 125/351 (35%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRY +I PY+ +RV+L + +E+E YI
Sbjct: 154 KNRYTNILPYDFSRVRLV-----------------------------SMNEEEGA--DYI 182
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NANY+ P Q YIATQ PL ET +DF+ +L II+ LT E
Sbjct: 183 NANYI--PGYNSPQE---------YIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 231
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
KC ++W E D ++ S E+D +A RH ++N +
Sbjct: 232 RRVKCDHYWP-----------FTEEPIAYGDITVEMISEEEQDDWAC---RHFRINYADE 277
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLG--TLLKPNEILQIINLKNFVIDSLF 824
++ WPD G T ILQ +++
Sbjct: 278 MQ-------------------DVMHFNYTAWPDHGVPTANAAESILQFVHMV-------- 310
Query: 825 AHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNL 884
+ +++HCSAG GRTGT +D +L +++ +
Sbjct: 311 --RQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE------------------- 349
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCL 935
F I+ V++ R R+SMVQ Q++FI+ C+
Sbjct: 350 -------------------FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 381
>Hs13677216 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 377
Score = 73.2 bits (178), Expect = 2e-12
Identities = 82/351 (23%), Positives = 126/351 (35%), Gaps = 125/351 (35%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRY +I PY+ +RV+L + +E+E YI
Sbjct: 126 KNRYTNILPYDFSRVRLV-----------------------------SMNEEEGA--DYI 154
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NANY+ P Q YIATQ PL ET +DF+ +L II+ LT E
Sbjct: 155 NANYI--PGYNSPQE---------YIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 203
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
KC ++W E D ++ S E+D +A RH ++N +
Sbjct: 204 RRVKCDHYWP-----------FTEEPIAYGDITVEMISEEEQDDWAC---RHFRINYADE 249
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLG--TLLKPNEILQIINLKNFVIDSLF 824
++ WPD G T ILQ +++
Sbjct: 250 MQ-------------------DVMHFNYTAWPDHGVPTANAAESILQFVHMV-------- 282
Query: 825 AHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNL 884
+ +++HCSAG GRTGT +D +L +++ +
Sbjct: 283 --RQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE------------------- 321
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCL 935
F I+ V++ R R+SMVQ Q++FI+ C+
Sbjct: 322 -------------------FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 353
>Hs13677214 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 1216
Score = 73.2 bits (178), Expect = 2e-12
Identities = 82/351 (23%), Positives = 126/351 (35%), Gaps = 125/351 (35%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRY +I PY+ +RV+L + +E+E YI
Sbjct: 965 KNRYTNILPYDFSRVRLV-----------------------------SMNEEEGA--DYI 993
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NANY+ P Q YIATQ PL ET +DF+ +L II+ LT E
Sbjct: 994 NANYI--PGYNSPQE---------YIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1042
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
KC ++W E D ++ S E+D +A RH ++N +
Sbjct: 1043 RRVKCDHYWP-----------FTEEPIAYGDITVEMISEEEQDDWAC---RHFRINYADE 1088
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLG--TLLKPNEILQIINLKNFVIDSLF 824
++ WPD G T ILQ +++
Sbjct: 1089 MQ-------------------DVMHFNYTAWPDHGVPTANAAESILQFVHMV-------- 1121
Query: 825 AHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNL 884
+ +++HCSAG GRTGT +D +L +++ +
Sbjct: 1122 --RQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE------------------- 1160
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCL 935
F I+ V++ R R+SMVQ Q++FI+ C+
Sbjct: 1161 -------------------FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1192
>YDL230w [T] KOG0789 Protein tyrosine phosphatase
Length = 335
Score = 71.2 bits (173), Expect = 7e-12
Identities = 94/392 (23%), Positives = 149/392 (37%), Gaps = 90/392 (22%)
Query: 558 EDGHYDVDEDDAEENLQSITISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXX 617
EDG + + S+ +S +NRY +I PYE RV L S
Sbjct: 26 EDGRLREATNGTVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLS---------- 75
Query: 618 XXXXXXXXXXXXXGLPTQDEQEDVWNTYINANYL-VNPFAQLQQSSTADIKSVRYIATQA 676
N YINA+Y+ VN Q I+ YIATQ
Sbjct: 76 ------------------------GNDYINASYVKVNVPGQ-------SIEPGYYIATQG 104
Query: 677 PLKETISDFY-----TCILNNNVPIILTLTDEFENGVEKCCNFWANGNYDGINVKLLDEF 731
P ++T F+ C L+N V +++T E+ EKC +W G D V++ ++
Sbjct: 105 PTRKTWDQFWQMCYHNCPLDNIVIVMVTPLVEYNR--EKCYQYWPRGGVDD-TVRIASKW 161
Query: 732 STMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQ 791
+ +N + + ++K D K +
Sbjct: 162 ES-------PGGANDMTQFPSDLKIEFVNVHKVKDYYTVTDIKLTPTDPLVGPVK-TVHH 213
Query: 792 LQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTL 851
W D+ KP E++ I+ L AH+ + ++VHCSAG GRTGT
Sbjct: 214 FYFDLWKDMN---KPEEVVPIMEL--------CAHSHSLNSRGNPIIVHCSAGVGRTGTF 262
Query: 852 CTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTV 911
+D ++ + F N++ ++ +S AT+ T + + IV
Sbjct: 263 IALDHLMHDTLDF-----------------KNITERSR-HSDRATEEYTRDLIEQIVL-- 302
Query: 912 NQFRRQRISMVQNINQFLFIYDCLLFYFTLNL 943
Q R QR+ MVQ +QFLFIY + +L++
Sbjct: 303 -QLRSQRMKMVQTKDQFLFIYHAAKYLNSLSV 333
>Hs18860904 [T] KOG4228 Protein tyrosine phosphatase
Length = 1452
Score = 70.9 bits (172), Expect = 9e-12
Identities = 79/352 (22%), Positives = 118/352 (33%), Gaps = 127/352 (36%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRY +I Y+H+RV+L Q + D + YI
Sbjct: 926 KNRYGNIIAYDHSRVRL-------------------------------QTIEGDTNSDYI 954
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
N NY+ + YIATQ P++ETI DF+ + + N I+ +T+ E
Sbjct: 955 NGNYIDGYH-----------RPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEV 1003
Query: 707 GVEKCCNFWANGN--YDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKT 764
G KCC +W + Y I V L+ E ++ A R + K
Sbjct: 1004 GRVKCCKYWPDDTEIYKDIKVTLI------------------ETELLAEYVIRTFAVEKR 1045
Query: 765 SDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLF 824
++ Q WPD G +L +
Sbjct: 1046 GVHEIR-----------------EIRQFHFTGWPDHGVPYHATGLLGFVR---------- 1078
Query: 825 AHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNL 884
SP ++VHCSAG GRTG +D +L D E +
Sbjct: 1079 QVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIML------DMAEREGVV----------- 1121
Query: 885 SPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLL 936
I V + R +R++MVQ Q++FI+D +L
Sbjct: 1122 ---------------------DIYNCVRELRSRRVNMVQTEEQYVFIHDAIL 1152
>CE20481 [T] KOG0789 Protein tyrosine phosphatase
Length = 398
Score = 70.9 bits (172), Expect = 9e-12
Identities = 81/354 (22%), Positives = 124/354 (34%), Gaps = 121/354 (34%)
Query: 586 TKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTY 645
TKNRY+D+ + + VKL S C+ Y
Sbjct: 133 TKNRYQDVPCQDQSAVKLDQPSPCN----------------------------------Y 158
Query: 646 INANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFE 705
I+ANY+ P I R+I Q PL +TI +F+ ++ N V I+ L E
Sbjct: 159 IHANYVGCPM----------IPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVE 208
Query: 706 NGVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTS 765
G KC +W + + +K + KPM+ + + M
Sbjct: 209 MGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITML-------------- 254
Query: 766 DXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFA 825
L+Y+ ++ + LQ +WPD G P L + L + + S
Sbjct: 255 -----------NLTYSGGQT-MSVRHLQWTEWPDRGV---PPCKLTSLELLSAIRGS--- 296
Query: 826 HNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLS 885
++VHCSAG GRTGT+ ++ IL +
Sbjct: 297 --------KVPIVVHCSAGIGRTGTIVAIEYILEKI------------------------ 324
Query: 886 PTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLLFYF 939
+ KP P+ V R QR +QN Q+LFI+ +L YF
Sbjct: 325 --------AENKP-----CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF 365
>SPAC11E3.09 [T] KOG0791 Protein tyrosine phosphatase contains fn3 domain
Length = 303
Score = 69.7 bits (169), Expect = 2e-11
Identities = 90/350 (25%), Positives = 136/350 (38%), Gaps = 119/350 (34%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
+NRY +I PYE+TRV+L P E D YI
Sbjct: 52 RNRYSNIVPYENTRVRLD----------------------------PMWKEACD----YI 79
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVP---IILTLTDE 703
NA+ + P + +IATQ P +I F+ + + VP II+ LT
Sbjct: 80 NASIVKIPSGKT------------FIATQGPTSNSIDVFWKMVWQS-VPKSGIIVMLTKL 126
Query: 704 FENGVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNK 763
E KC +W ++ +N+ L +++ K S +E + R +LNK
Sbjct: 127 RERHRLKCDIYWPVELFETLNIGDL----SVILVKVYTLTSLNEVQV------REFELNK 176
Query: 764 TSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSL 823
D K ++L WPD G +++L + I SL
Sbjct: 177 -------------------DGVKKKILHFYYNGWPDFGA----PHTFSLLSLTRY-IKSL 212
Query: 824 FAHNVYSPNY-TPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTP 882
YSP++ T ++VHCSAGCGRTGT + ILS TD++
Sbjct: 213 S----YSPDFETAPIIVHCSAGCGRTGTFMALFEILSQ-----TDDS------------- 250
Query: 883 NLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIY 932
T ++ F D I V+ R QR+ VQ+++Q +F+Y
Sbjct: 251 -----TSTSKFEV---------DNIANIVSSLRSQRMQSVQSVDQLVFLY 286
>CE09981 [T] KOG0789 Protein tyrosine phosphatase
Length = 398
Score = 69.7 bits (169), Expect = 2e-11
Identities = 81/354 (22%), Positives = 124/354 (34%), Gaps = 121/354 (34%)
Query: 586 TKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTY 645
TKNRY+D+ + + VKL S C+ Y
Sbjct: 133 TKNRYQDVPCQDLSAVKLDQPSPCN----------------------------------Y 158
Query: 646 INANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFE 705
I+ANY+ P I R+I Q PL +TI +F+ ++ N V I+ L E
Sbjct: 159 IHANYVGCPM----------IPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVE 208
Query: 706 NGVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTS 765
G KC +W + + +K + KPM+ + + M
Sbjct: 209 MGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITML-------------- 254
Query: 766 DXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFA 825
L+Y+ ++ + LQ +WPD G P L + L + + S
Sbjct: 255 -----------NLTYSGGQT-MSVRHLQWTEWPDRGV---PPCKLTSLELLSAIRGS--- 296
Query: 826 HNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLS 885
++VHCSAG GRTGT+ ++ IL +
Sbjct: 297 --------KVPIVVHCSAGIGRTGTIVAIEYILEKI------------------------ 324
Query: 886 PTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCLLFYF 939
+ KP P+ V R QR +QN Q+LFI+ +L YF
Sbjct: 325 --------AENKP-----CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF 365
>Hs18641364 [T] KOG4228 Protein tyrosine phosphatase
Length = 1256
Score = 67.4 bits (163), Expect = 1e-10
Identities = 72/360 (20%), Positives = 122/360 (33%), Gaps = 98/360 (27%)
Query: 578 ISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDE 637
I + E +KNR ++ PY++ RV L H S E+ D
Sbjct: 912 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD------------DDS 959
Query: 638 QEDVWNTYINANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPII 697
+ + YINA+++++ + K IA Q PLKETI DF+ I V +I
Sbjct: 960 DSEEPSKYINASFIMSYW-----------KPEVMIAAQGPLKETIGDFWQMIFQRKVKVI 1008
Query: 698 LTLTDEFENGVEKCCNFWANG--NYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKF 755
+ LT+ E C +W G Y I V L
Sbjct: 1009 VMLTELKHGDQEICAQYWGEGKQTYGDIEVDL---------------------------- 1040
Query: 756 WRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINL 815
K +D L ++ + + Q Q +W +P E++ +I +
Sbjct: 1041 -------KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQV 1093
Query: 816 KNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGA 875
+ + + + +L+HC G +TG C ++L+ L+ +T+E ++
Sbjct: 1094 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFC---ALLNLLESAETEEVVDIF-- 1148
Query: 876 FAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCL 935
V R+ R MV Q+ F+YD +
Sbjct: 1149 ---------------------------------QVVKALRKARPGMVSTFEQYQFLYDVI 1175
>Hs18641362 [T] KOG4228 Protein tyrosine phosphatase
Length = 1143
Score = 67.4 bits (163), Expect = 1e-10
Identities = 72/360 (20%), Positives = 122/360 (33%), Gaps = 98/360 (27%)
Query: 578 ISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDE 637
I + E +KNR ++ PY++ RV L H S E+ D
Sbjct: 799 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD------------DDS 846
Query: 638 QEDVWNTYINANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPII 697
+ + YINA+++++ + K IA Q PLKETI DF+ I V +I
Sbjct: 847 DSEEPSKYINASFIMSYW-----------KPEVMIAAQGPLKETIGDFWQMIFQRKVKVI 895
Query: 698 LTLTDEFENGVEKCCNFWANG--NYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKF 755
+ LT+ E C +W G Y I V L
Sbjct: 896 VMLTELKHGDQEICAQYWGEGKQTYGDIEVDL---------------------------- 927
Query: 756 WRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINL 815
K +D L ++ + + Q Q +W +P E++ +I +
Sbjct: 928 -------KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQV 980
Query: 816 KNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGA 875
+ + + + +L+HC G +TG C ++L+ L+ +T+E ++
Sbjct: 981 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFC---ALLNLLESAETEEVVDIF-- 1035
Query: 876 FAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCL 935
V R+ R MV Q+ F+YD +
Sbjct: 1036 ---------------------------------QVVKALRKARPGMVSTFEQYQFLYDVI 1062
>Hs18641347 [T] KOG4228 Protein tyrosine phosphatase
Length = 1304
Score = 67.4 bits (163), Expect = 1e-10
Identities = 72/360 (20%), Positives = 122/360 (33%), Gaps = 98/360 (27%)
Query: 578 ISSGVEFGTKNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDE 637
I + E +KNR ++ PY++ RV L H S E+ D
Sbjct: 960 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD------------DDS 1007
Query: 638 QEDVWNTYINANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPII 697
+ + YINA+++++ + K IA Q PLKETI DF+ I V +I
Sbjct: 1008 DSEEPSKYINASFIMSYW-----------KPEVMIAAQGPLKETIGDFWQMIFQRKVKVI 1056
Query: 698 LTLTDEFENGVEKCCNFWANG--NYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKF 755
+ LT+ E C +W G Y I V L
Sbjct: 1057 VMLTELKHGDQEICAQYWGEGKQTYGDIEVDL---------------------------- 1088
Query: 756 WRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINL 815
K +D L ++ + + Q Q +W +P E++ +I +
Sbjct: 1089 -------KDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQV 1141
Query: 816 KNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGTLCTVDSILSNLKKFDTDENPSLYGA 875
+ + + + +L+HC G +TG C ++L+ L+ +T+E ++
Sbjct: 1142 VKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFC---ALLNLLESAETEEVVDIF-- 1196
Query: 876 FAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTTVNQFRRQRISMVQNINQFLFIYDCL 935
V R+ R MV Q+ F+YD +
Sbjct: 1197 ---------------------------------QVVKALRKARPGMVSTFEQYQFLYDVI 1223
>CE24794 [T] KOG4228 Protein tyrosine phosphatase
Length = 2234
Score = 65.5 bits (158), Expect = 4e-10
Identities = 56/193 (29%), Positives = 79/193 (40%), Gaps = 42/193 (21%)
Query: 671 YIATQAPLKETISDFYTCILNNNVPIILTLTDEFENGVEKCCNFWANGNYDGINVKLLDE 730
YIATQAP ET +DF+ I +N PII L E G E+C ++W
Sbjct: 2037 YIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYW--------------P 2082
Query: 731 FSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYNNDRSKFQLL 790
T +Q + E E DM K + HL+ + SD N R +
Sbjct: 2083 LETGVQVGMLVVEPMAEYDM---KHY-HLREFRISDI--------------NTREVRTVR 2124
Query: 791 QLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSP-NYTPTVLVHCSAGCGRTG 849
Q +WPD+G KP+ ++ V HN Y+ T + VHC +G GRT
Sbjct: 2125 QFHFMEWPDVG---KPHTADHFLDFVTQV------HNTYAQFGCTGPITVHCCSGAGRTA 2175
Query: 850 TLCTVDSILSNLK 862
+ IL ++
Sbjct: 2176 VFIALSIILDRMR 2188
>Hs18375644 [T] KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2
domain enzymes
Length = 460
Score = 65.1 bits (157), Expect = 5e-10
Identities = 60/227 (26%), Positives = 92/227 (40%), Gaps = 63/227 (27%)
Query: 587 KNRYKDIFPYEHTRVKLSHSSICSAGCENXXXXXXXXXXXXXXXGLPTQDEQEDVWNTYI 646
KNRYK+I P++HTRV L D E V + YI
Sbjct: 276 KNRYKNILPFDHTRVVLHDG-----------------------------DPNEPV-SDYI 305
Query: 647 NANYLVNPFAQLQQSSTADIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFEN 706
NAN ++ F + + +++ KS YIATQ L+ T++DF+ + N +I+ T E E
Sbjct: 306 NANIIMPEF-ETKCNNSKPKKS--YIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER 362
Query: 707 GVEKCCNFWANGNYDGINVKLLDEFSTMLQDKPMKAESNHEEDMFASKFWRHLKLNKTSD 766
G KC +W DE++ L++ + N +E R LKL+K
Sbjct: 363 GKSKCVKYWP------------DEYA--LKEYGVMRVRNVKESAAHDYTLRELKLSKVGQ 408
Query: 767 XXXXXXXXXXXLSYNNDRSKFQLLQLQIKDWPDLGTLLKPNEILQII 813
N +R+ + Q + WPD G P +L +
Sbjct: 409 G-------------NTERT---VWQYHFRTWPDHGVPSDPGGVLDFL 439
>Hs19743914 [T] KOG0793 Protein tyrosine phosphatase
Length = 986
Score = 63.9 bits (154), Expect = 1e-09
Identities = 50/202 (24%), Positives = 85/202 (41%), Gaps = 47/202 (23%)
Query: 665 DIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFENGVEKCCNFWANGNYDGIN 724
D ++ YIATQ PL T++DF+ + + +I+ LT ENGV +C ++W
Sbjct: 781 DPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP-------- 832
Query: 725 VKLLDEFSTMLQDKPMKAESNH---EEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYN 781
DE S + + S H E+ + S + ++L+ N+T
Sbjct: 833 ----DEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETR---------------- 872
Query: 782 NDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHC 841
+ Q W D G P+ +++ + V + Y P ++VHC
Sbjct: 873 ------TVTQFHFLSWYDRGV---PSSSRSLLDFRRKV------NKCYRGRSCP-IIVHC 916
Query: 842 SAGCGRTGTLCTVDSILSNLKK 863
S G GR+GT +D +L+ + K
Sbjct: 917 SDGAGRSGTYVLIDMVLNKMAK 938
>Hs19743912 [T] KOG0793 Protein tyrosine phosphatase
Length = 998
Score = 63.9 bits (154), Expect = 1e-09
Identities = 50/202 (24%), Positives = 85/202 (41%), Gaps = 47/202 (23%)
Query: 665 DIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFENGVEKCCNFWANGNYDGIN 724
D ++ YIATQ PL T++DF+ + + +I+ LT ENGV +C ++W
Sbjct: 793 DPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP-------- 844
Query: 725 VKLLDEFSTMLQDKPMKAESNH---EEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYN 781
DE S + + S H E+ + S + ++L+ N+T
Sbjct: 845 ----DEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETR---------------- 884
Query: 782 NDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHC 841
+ Q W D G P+ +++ + V + Y P ++VHC
Sbjct: 885 ------TVTQFHFLSWYDRGV---PSSSRSLLDFRRKV------NKCYRGRSCP-IIVHC 928
Query: 842 SAGCGRTGTLCTVDSILSNLKK 863
S G GR+GT +D +L+ + K
Sbjct: 929 SDGAGRSGTYVLIDMVLNKMAK 950
>Hs11386149 [T] KOG0793 Protein tyrosine phosphatase
Length = 1015
Score = 63.9 bits (154), Expect = 1e-09
Identities = 50/202 (24%), Positives = 85/202 (41%), Gaps = 47/202 (23%)
Query: 665 DIKSVRYIATQAPLKETISDFYTCILNNNVPIILTLTDEFENGVEKCCNFWANGNYDGIN 724
D ++ YIATQ PL T++DF+ + + +I+ LT ENGV +C ++W
Sbjct: 810 DPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP-------- 861
Query: 725 VKLLDEFSTMLQDKPMKAESNH---EEDMFASKFWRHLKLNKTSDXXXXXXXXXXXLSYN 781
DE S + + S H E+ + S + ++L+ N+T
Sbjct: 862 ----DEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETR---------------- 901
Query: 782 NDRSKFQLLQLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHC 841
+ Q W D G P+ +++ + V + Y P ++VHC
Sbjct: 902 ------TVTQFHFLSWYDRGV---PSSSRSLLDFRRKV------NKCYRGRSCP-IIVHC 945
Query: 842 SAGCGRTGTLCTVDSILSNLKK 863
S G GR+GT +D +L+ + K
Sbjct: 946 SDGAGRSGTYVLIDMVLNKMAK 967
>CE28359 [T] KOG0789 Protein tyrosine phosphatase
Length = 456
Score = 58.5 bits (140), Expect = 5e-08
Identities = 41/148 (27%), Positives = 63/148 (41%), Gaps = 42/148 (28%)
Query: 791 QLQIKDWPDLGTLLKPNEILQIINLKNFVIDSLFAHNVYSPNYTPTVLVHCSAGCGRTGT 850
QL ++WPD G ++L +I+L + H SP + +LVHCSAG GRTGT
Sbjct: 249 QLHYREWPDHGCPSGEKQLLNMIDLMENI------HEEVSPQDSSPILVHCSAGVGRTGT 302
Query: 851 LCTVDSILSNLKKFDTDENPSLYGAFAVPLTPNLSPTTKSNSFSATKPPTSLMFDPIVTT 910
+ ++ I +K +T + ++G
Sbjct: 303 IIAINFIREQMKA-ETLHSIDIFG-----------------------------------L 326
Query: 911 VNQFRRQRISMVQNINQFLFIYDCLLFY 938
V R+QR SMVQ +QF F++ C+ Y
Sbjct: 327 VMTLRKQRASMVQTQDQFQFVHRCIASY 354
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.132 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,355,475
Number of Sequences: 60738
Number of extensions: 2276427
Number of successful extensions: 6579
Number of sequences better than 1.0e-05: 34
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 6448
Number of HSP's gapped (non-prelim): 122
length of query: 983
length of database: 30,389,216
effective HSP length: 116
effective length of query: 867
effective length of database: 23,343,608
effective search space: 20238908136
effective search space used: 20238908136
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)