ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2160 check: MH L KOG0287 Replication, recombination and repair Postreplication repair protein RAD18
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2160 767130 765850 -427
(427 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YCR066w [L] KOG0287 Postreplication repair protein RAD18 278 9e-75
SPBC1734.06 [L] KOG0287 Postreplication repair protein RAD18 153 4e-37
Hs14550405 [L] KOG0287 Postreplication repair protein RAD18 86 8e-17
At2g32950_1 [T] KOG0297 TNF receptor-associated factor 64 4e-10
Hs6552321 [LK] KOG4362 Transcriptional regulator BRCA1 60 6e-09
Hs6552313 [LK] KOG4362 Transcriptional regulator BRCA1 59 1e-08
Hs6552311 [LK] KOG4362 Transcriptional regulator BRCA1 59 1e-08
Hs6552309 [LK] KOG4362 Transcriptional regulator BRCA1 59 1e-08
Hs6552299 [LK] KOG4362 Transcriptional regulator BRCA1 59 1e-08
Hs6552315 [LK] KOG4362 Transcriptional regulator BRCA1 59 1e-08
Hs6552319 [LK] KOG4362 Transcriptional regulator BRCA1 58 2e-08
Hs6552317 [LK] KOG4362 Transcriptional regulator BRCA1 58 2e-08
Hs6552307 [LK] KOG4362 Transcriptional regulator BRCA1 58 2e-08
YOL054w [O] KOG2177 Predicted E3 ubiquitin ligase 57 5e-08
SPAC144.05 [L] KOG0298 DEAD box-containing helicase-like transcr... 53 8e-07
Hs13376134_2 [O] KOG4159 Predicted E3 ubiquitin ligase 53 1e-06
CE26718 [O] KOG1813 Predicted E3 ubiquitin ligase 52 1e-06
Hs4504867 [T] KOG3872 FOG: FHA domain 52 2e-06
7295191 [O] KOG4159 Predicted E3 ubiquitin ligase 52 2e-06
At1g18660 [O] KOG4159 Predicted E3 ubiquitin ligase 51 4e-06
CE00312 [O] KOG2177 Predicted E3 ubiquitin ligase 50 6e-06
Hs20162564 [O] KOG2177 Predicted E3 ubiquitin ligase 50 8e-06
At4g03510 [O] KOG0823 Predicted E3 ubiquitin ligase 50 8e-06
7290897 [T] KOG0297 TNF receptor-associated factor 50 8e-06
>YCR066w [L] KOG0287 Postreplication repair protein RAD18
Length = 487
Score = 278 bits (712), Expect = 9e-75
Identities = 166/416 (39%), Positives = 227/416 (53%), Gaps = 44/416 (10%)
Query: 9 ISNPRDFLHTSVPQLTDLDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPL 68
I+ DF TS+P L LD+LLRCHICKDFLK VLTPCGH+FCS+CIR +L + CPL
Sbjct: 5 ITTASDFTTTSIPSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQPNCPL 64
Query: 69 CLSDLTESMLQKEFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEII-----------I 117
CL + ES+L+ EFLV EI SY LR SL L I +NE + I
Sbjct: 65 CLFEFRESLLRSEFLVSEIIQSYTSLRSSLLDALRIPKPTPVPENEEVPGPENSSWIELI 124
Query: 118 SDEADTSVG----------------TKRGTPDSPSLSSVSTKKRKHDGITTLLMKKKTDH 161
S+ SV KR D LSS KR + +KKK+
Sbjct: 125 SESESDSVNAADDDLQIVATSERKLAKRSMTDILPLSS-KPSKRNFAMFRSERIKKKS-- 181
Query: 162 PQRQEKKAQCPICSKHLPLSELEGSHIDECLNKGSSLERSDSFEILDERTPSPSMESSHQ 221
+ E+ AQCPIC + PL LE +H+DECL SL + +P +SS +
Sbjct: 182 -KPNEQMAQCPICQQFYPLKALEKTHLDECLTL-QSLGKKPKISTTFPTESNPHNKSSSR 239
Query: 222 PLEEKTSLPSSHLLEVKEKKDITYHNERYLNSGLLQQKENRLPRLDFQSLSMTQLKQKLA 281
+ S E T H ++YLNS ++ + RLP+++F S++ +Q+KQKL+
Sbjct: 240 FKVRTPEVDKSSCGE-------TSHVDKYLNS-MMSAEHQRLPKINFTSMTQSQIKQKLS 291
Query: 282 SLALPSNGTKQQMVARYKHYEMLWNSNFLDSIDPVDENELKRRLSSWEAKHNTDHSSDSN 341
SL L +NGT+Q M+ RY HYEMLWNSNF DS++PVDE ELKR+L SW+ HN + SN
Sbjct: 292 SLGLSTNGTRQNMIKRYNHYEMLWNSNFCDSLEPVDEAELKRQLLSWDVSHNKTPQNSSN 351
Query: 342 ----SITNLLRGNKRTNAISAMIKLFKSDRFDRKGWMRHHTSTFKALKLEAQRSDK 393
S +++ N ++++ +++ FK+D+F+RKGWM F L EA+ K
Sbjct: 352 KGGISKLMIMKSNGKSSSYRKLLENFKNDKFNRKGWMVMFRKDFARLIREAKMKIK 407
>SPBC1734.06 [L] KOG0287 Postreplication repair protein RAD18
Length = 387
Score = 153 bits (387), Expect = 4e-37
Identities = 107/325 (32%), Positives = 169/325 (51%), Gaps = 36/325 (11%)
Query: 10 SNPRDFLHTSVPQLTDLDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLC 69
++P D+ T +P L LDS LRC IC ++ +A ++T C H+FCS CIR YL++ CP C
Sbjct: 7 TDPSDWNQTKIPSLKGLDSSLRCLICHEYFRAPLITSCSHTFCSFCIRDYLREHPMCPAC 66
Query: 70 LSDLTESMLQKEFLVQEICSSYVKLRGSLQKHLTISSQEEE--KDNEIIISDEADTSVGT 127
+ ES L+K +++EI S+ +R +L + L + + + + E +I+ D++ G
Sbjct: 67 RAPEQESRLRKNTILEEILESFKVIRPTLFEFLKVENVPKPVLQAPETVIAQ--DSASGD 124
Query: 128 KRGTPDSPSLSSVSTKKRKHDGITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELEGSH 187
+ D S SS ++ +K T+ KK+ ++E CP CS +P +++ H
Sbjct: 125 EEWEDDLASNSSPASIAKK----TSRDSKKR-----KREDLVHCPACSNLVPHNQI-NQH 174
Query: 188 IDECLNKGSSLERSDSFEILDERTPSPSMESSHQPLEEKTSLPSSHLLEVKEKKD-ITYH 246
+D CLN SS PS SS P + K + S+ LL K D IT
Sbjct: 175 LDSCLNSPSS--------------PS----SSSSPYKNKDNSKSNSLLSFKTDDDSITKR 216
Query: 247 NERYLNSG--LLQQKENRLPRLDFQSLSMTQLKQKLASLALPSNGTKQQMVARYKHYEML 304
R NS L + RLP+L + LS ++++ KL+ + LP++G KQ + R+ + L
Sbjct: 217 RLRSFNSADELPLKDRVRLPKLTYALLSESKIRSKLSEMGLPTDGHKQLLQRRHAKWVTL 276
Query: 305 WNSNFLDSIDPVDENELKRRLSSWE 329
+NSN LD PV + L R+L WE
Sbjct: 277 YNSN-LDQKQPVSKRNLIRQLIDWE 300
>Hs14550405 [L] KOG0287 Postreplication repair protein RAD18
Length = 495
Score = 86.3 bits (212), Expect = 8e-17
Identities = 90/403 (22%), Positives = 166/403 (40%), Gaps = 56/403 (13%)
Query: 26 LDSLLRCHICKDFLKASVLTP-CGHSFCSICIRKYLQKESKCPLCLSDLTESMLQKEFLV 84
+D LLRC IC ++ +++ P C H++CS+CIRK+L +++CP C +TE L+ ++
Sbjct: 19 IDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTVTEPDLKNNRIL 78
Query: 85 QEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEADTSVGTKRGTPDSPSLSSVSTKK 144
E+ VK + HL + E + + + ++ K TP + S S+
Sbjct: 79 DEL----VKSLNFARNHLLQFALESPAKSP---ASSSSKNLAVKVYTPVA-SRQSLKQGS 130
Query: 145 RKHDGITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELEGSHIDECLNKGSSLERSDSF 204
R D M T +E K SK P E S ++
Sbjct: 131 RLMDNFLIREMSGSTSELLIKENK------SKFSPQKE------------ASPAAKTKET 172
Query: 205 EILDERTPSPSMESSHQPLEEKT--------------SLPSSHLLEVKEKKDITYHNERY 250
++E P PS +P T ++P SH+ + + +
Sbjct: 173 RSVEEIAPDPSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKES 232
Query: 251 LNSGLLQQKENRLPRLDFQSLSMTQLKQKLASLALPSNGTKQQMVARYKHYEMLWNSNFL 310
L S + K LP+ + LS LK+KL L G KQQ++ R++ + ++N+
Sbjct: 233 LRSSV--HKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQ-C 289
Query: 311 DSIDPVDENELKRRLSSWEAKHNTDHSSDSNSITNLLRGNKRTNAISAMIKLFKSDRFDR 370
D++ P E+ + + + E +S N + ++ I + ++
Sbjct: 290 DALHPKSAAEIVQEIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYR------ 343
Query: 371 KGWMRHHTSTFKALKLEAQRS-DKLAKMKKEELS-QKSDANSE 411
+ H S F+ L +A++ K+A M ++ ++ K D ++E
Sbjct: 344 ----KKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTE 382
>At2g32950_1 [T] KOG0297 TNF receptor-associated factor
Length = 182
Score = 63.9 bits (154), Expect = 4e-10
Identities = 28/63 (44%), Positives = 38/63 (59%)
Query: 25 DLDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTESMLQKEFLV 84
DLD L C IC +K + LT CGHSFC +CI +L+ +S CP C LT + L FL+
Sbjct: 45 DLDKDLLCPICMQIIKDAFLTACGHSFCYMCIITHLRNKSDCPCCSQHLTNNQLYPNFLL 104
Query: 85 QEI 87
++
Sbjct: 105 DKL 107
>Hs6552321 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 719
Score = 60.1 bits (144), Expect = 6e-09
Identities = 59/250 (23%), Positives = 111/250 (43%), Gaps = 36/250 (14%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELE 184
+ P++PSL S + + G L K+ PQ+ + C SE +
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELAACE----FSETD 191
Query: 185 GSHIDECLNKGSSLERSDSFEILDERTP-------SPSMESSHQPLEEKTSLPSSHLLEV 237
++ + ++ S+ + + + + ER P + ES E+ + L S +
Sbjct: 192 VTNTEH--HQPSNNDLNTTEKRAAERHPEKYQGEAASGCESETSVSEDCSGLSSQSDILT 249
Query: 238 KEKKDITYHN 247
+++D HN
Sbjct: 250 TQQRDTMQHN 259
>Hs6552313 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 1496
Score = 59.3 bits (142), Expect = 1e-08
Identities = 64/263 (24%), Positives = 114/263 (43%), Gaps = 47/263 (17%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELE 184
+ P++PSL S + + G L K+ PQ K EL
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQ------------KTSVYIELG 183
Query: 185 GSHIDECLNKGS--SLERSDSFEILDERTPSP-SMESSHQPLEEKTSL---------PSS 232
++ +NK + S+ + +I + T S++S+ + E + PS+
Sbjct: 184 SDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSN 243
Query: 233 HLLEVKEKKDITYHNERYLNSGL 255
+ L EK+ H E+Y S +
Sbjct: 244 NDLNTTEKRAAERHPEKYQGSSV 266
>Hs6552311 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 1598
Score = 59.3 bits (142), Expect = 1e-08
Identities = 64/263 (24%), Positives = 114/263 (43%), Gaps = 47/263 (17%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELE 184
+ P++PSL S + + G L K+ PQ K EL
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQ------------KTSVYIELG 183
Query: 185 GSHIDECLNKGS--SLERSDSFEILDERTPSP-SMESSHQPLEEKTSL---------PSS 232
++ +NK + S+ + +I + T S++S+ + E + PS+
Sbjct: 184 SDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSN 243
Query: 233 HLLEVKEKKDITYHNERYLNSGL 255
+ L EK+ H E+Y S +
Sbjct: 244 NDLNTTEKRAAERHPEKYQGSSV 266
>Hs6552309 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 1624
Score = 59.3 bits (142), Expect = 1e-08
Identities = 64/263 (24%), Positives = 114/263 (43%), Gaps = 47/263 (17%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELE 184
+ P++PSL S + + G L K+ PQ K EL
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQ------------KTSVYIELG 183
Query: 185 GSHIDECLNKGS--SLERSDSFEILDERTPSP-SMESSHQPLEEKTSL---------PSS 232
++ +NK + S+ + +I + T S++S+ + E + PS+
Sbjct: 184 SDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSN 243
Query: 233 HLLEVKEKKDITYHNERYLNSGL 255
+ L EK+ H E+Y S +
Sbjct: 244 NDLNTTEKRAAERHPEKYQGSSV 266
>Hs6552299 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 1863
Score = 59.3 bits (142), Expect = 1e-08
Identities = 64/263 (24%), Positives = 114/263 (43%), Gaps = 47/263 (17%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQRQEKKAQCPICSKHLPLSELE 184
+ P++PSL S + + G L K+ PQ K EL
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQ------------KTSVYIELG 183
Query: 185 GSHIDECLNKGS--SLERSDSFEILDERTPSP-SMESSHQPLEEKTSL---------PSS 232
++ +NK + S+ + +I + T S++S+ + E + PS+
Sbjct: 184 SDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSN 243
Query: 233 HLLEVKEKKDITYHNERYLNSGL 255
+ L EK+ H E+Y S +
Sbjct: 244 NDLNTTEKRAAERHPEKYQGSSV 266
>Hs6552315 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 1822
Score = 58.9 bits (141), Expect = 1e-08
Identities = 45/170 (26%), Positives = 79/170 (46%), Gaps = 23/170 (13%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQRQEKKAQCPIC 174
+ P++PSL S + + G L K+ PQ+ + C
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELAAC 185
>Hs6552319 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 759
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/160 (27%), Positives = 77/160 (47%), Gaps = 23/160 (14%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQR 164
+ P++PSL S + + G L K+ PQ+
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQK 175
>Hs6552317 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 721
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/160 (27%), Positives = 77/160 (47%), Gaps = 23/160 (14%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQR 164
+ P++PSL S + + G L K+ PQ+
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQK 175
>Hs6552307 [LK] KOG4362 Transcriptional regulator BRCA1
Length = 680
Score = 58.2 bits (139), Expect = 2e-08
Identities = 44/160 (27%), Positives = 77/160 (47%), Gaps = 23/160 (14%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKE---SKCPLCLSDLTESMLQK-- 80
+ +L C IC + +K V T C H FC C+ K L ++ S+CPLC +D+T+ LQ+
Sbjct: 18 MQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQEST 77
Query: 81 ------EFLVQEICSSYVKLRGSLQKHLTISSQEEEKDNEIIISDEAD--TSVGTK---- 128
E L++ IC+ +L L+ + + ++E ++ + DE S+G +
Sbjct: 78 RFSQLVEELLKIICA--FQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAK 135
Query: 129 ---RGTPDSPSLSSVSTKKRKHD-GITTLLMKKKTDHPQR 164
+ P++PSL S + + G L K+ PQ+
Sbjct: 136 RLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQK 175
>YOL054w [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 406
Score = 57.0 bits (136), Expect = 5e-08
Identities = 46/157 (29%), Positives = 65/157 (41%), Gaps = 17/157 (10%)
Query: 30 LRCHICKDFLKASVLTPCGHSFCSICIRKYL----QKESKCPLCLSDLTESMLQKEFLVQ 85
L C IC D++ ++TPCGH++C C+ + QKE CP C SD+T L Q
Sbjct: 28 LVCSICHDYMFVPMMTPCGHNYCYGCLNTWFASNTQKELACPQCRSDITTIPALNTTLQQ 87
Query: 86 EICSSYVKLRG----SLQKHLTISSQEEEKDNEIIISDEADTSVGTKRGTPDSPSLSSVS 141
+ KLR S +K LT ++EE N+ E DT S+++
Sbjct: 88 YLSFILEKLRDQNDESFKKLLTTKTKEE---NDYKNDKEKDTLFDKVFKN------SALA 138
Query: 142 TKKRKHDGITTLLMKKKTDHPQRQEKKAQCPICSKHL 178
DGIT P E CP C+ +
Sbjct: 139 VADDSDDGITRCSNCHWELDPDEVEDGNVCPHCNARI 175
>SPAC144.05 [L] KOG0298 DEAD box-containing helicase-like transcription
factor/DNA repair protein
Length = 1375
Score = 53.1 bits (126), Expect = 8e-07
Identities = 18/45 (40%), Positives = 29/45 (64%)
Query: 32 CHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTES 76
C IC+D +K +T CGH +CS C+ +L+ S CP+C + L ++
Sbjct: 1092 CIICRDIIKQGFITTCGHLYCSFCLEAWLKHSSSCPMCKTKLNKN 1136
>Hs13376134_2 [O] KOG4159 Predicted E3 ubiquitin ligase
Length = 375
Score = 52.8 bits (125), Expect = 1e-06
Identities = 23/78 (29%), Positives = 43/78 (54%), Gaps = 4/78 (5%)
Query: 19 SVPQLTDLDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTESML 78
S+P + S L C +C V TPCGH+FC C+ + L +KCPLC L++ +
Sbjct: 70 SLPLASFDASDLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLSQCLA 129
Query: 79 QKEF----LVQEICSSYV 92
+++ +++E+ + ++
Sbjct: 130 SRKYSKNVIMEELIAKFL 147
>CE26718 [O] KOG1813 Predicted E3 ubiquitin ligase
Length = 384
Score = 52.4 bits (124), Expect = 1e-06
Identities = 32/85 (37%), Positives = 46/85 (53%), Gaps = 10/85 (11%)
Query: 32 CHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTESMLQ--KEFLVQEICS 89
C IC + ++T C H FC+ C K QK SKCP+C + TE+++ KE L
Sbjct: 241 CFICGNPFVDPIVTKCKHYFCTGCALKSFQKSSKCPICQQN-TENIMNTAKELL------ 293
Query: 90 SYVKLRGSLQKHLTISSQEEEKDNE 114
+Y+K + QK QEEEKD++
Sbjct: 294 TYLKRKKQQQKQ-EAEKQEEEKDSD 317
>Hs4504867 [T] KOG3872 FOG: FHA domain
Length = 485
Score = 52.0 bits (123), Expect = 2e-06
Identities = 18/48 (37%), Positives = 33/48 (68%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDL 73
L++ L+C IC ++ +V C HSFCS CI ++++++ +CP+C D+
Sbjct: 397 LENELQCIICSEYFIEAVTLNCAHSFCSYCINEWMKRKIECPICRKDI 444
>7295191 [O] KOG4159 Predicted E3 ubiquitin ligase
Length = 593
Score = 51.6 bits (122), Expect = 2e-06
Identities = 19/44 (43%), Positives = 28/44 (63%)
Query: 32 CHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTE 75
C +C L V+TPCGH++C +C+ + + S CPLC+S L E
Sbjct: 215 CVVCSRTLWKPVVTPCGHTYCLVCLDRCMDYNSPCPLCMSPLVE 258
>At1g18660 [O] KOG4159 Predicted E3 ubiquitin ligase
Length = 302
Score = 50.8 bits (120), Expect = 4e-06
Identities = 22/86 (25%), Positives = 41/86 (47%), Gaps = 8/86 (9%)
Query: 32 CHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDLTESMLQKEFLVQEICSSY 91
C +C L TPCGH+FC C+ + + + +KCPLC + + F+ C+
Sbjct: 20 CTVCLKLLYEPATTPCGHTFCRSCLFQSMDRGNKCPLCRTVI--------FMTPRTCAVS 71
Query: 92 VKLRGSLQKHLTISSQEEEKDNEIII 117
V L ++K+ E + + + ++
Sbjct: 72 VTLNNIIEKNFPEEYAERKSEQDTLV 97
>CE00312 [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 160
Score = 50.1 bits (118), Expect = 6e-06
Identities = 25/84 (29%), Positives = 37/84 (43%), Gaps = 8/84 (9%)
Query: 32 CHICKDFLKASVLTPCGHSFCSICIRKYLQKESKCPLCLSDL--------TESMLQKEFL 83
C +C DF + CGHS+C CI +L KCPLC + ES+
Sbjct: 8 CAVCLDFFVEPCIIECGHSYCRFCIESHLNINEKCPLCRAHTGNPIRNRQLESLTMSYVS 67
Query: 84 VQEICSSYVKLRGSLQKHLTISSQ 107
+ I + Y + S QK L + ++
Sbjct: 68 SRNISTEYYERMKSYQKKLLLQNR 91
>Hs20162564 [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 229
Score = 49.7 bits (117), Expect = 8e-06
Identities = 24/67 (35%), Positives = 38/67 (55%), Gaps = 9/67 (13%)
Query: 32 CHICKDFLKASVLTPCGHSFCSICIRKYLQKESK-----CPLCLSDLTESMLQKEFLVQE 86
C IC++ LK +V T CGH FC +C+ ++++K S CPLC +E +L +
Sbjct: 14 CPICQESLKEAVSTNCGHLFCRVCLTQHVEKASASGVFCCPLCRKPCSEEVLGTGY---- 69
Query: 87 ICSSYVK 93
IC ++ K
Sbjct: 70 ICPNHQK 76
>At4g03510 [O] KOG0823 Predicted E3 ubiquitin ligase
Length = 249
Score = 49.7 bits (117), Expect = 8e-06
Identities = 27/71 (38%), Positives = 37/71 (52%), Gaps = 11/71 (15%)
Query: 19 SVPQLTDLDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYL-----------QKESKCP 67
SVP DS C+IC D ++ V+T CGH FC CI K+L Q+ +CP
Sbjct: 35 SVPSDDTDDSNFDCNICLDSVQEPVVTLCGHLFCWPCIHKWLDVQSFSTSDEYQRHRQCP 94
Query: 68 LCLSDLTESML 78
+C S ++ S L
Sbjct: 95 VCKSKVSHSTL 105
>7290897 [T] KOG0297 TNF receptor-associated factor
Length = 475
Score = 49.7 bits (117), Expect = 8e-06
Identities = 20/41 (48%), Positives = 26/41 (62%)
Query: 26 LDSLLRCHICKDFLKASVLTPCGHSFCSICIRKYLQKESKC 66
LDS C IC D+L VLT CGH FC C+ ++QK ++C
Sbjct: 98 LDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQC 138
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.312 0.127 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,677,525
Number of Sequences: 60738
Number of extensions: 1209485
Number of successful extensions: 5217
Number of sequences better than 1.0e-05: 24
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 5176
Number of HSP's gapped (non-prelim): 27
length of query: 427
length of database: 30,389,216
effective HSP length: 109
effective length of query: 318
effective length of database: 23,768,774
effective search space: 7558470132
effective search space used: 7558470132
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)