ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2284 good F KOG1436 Nucleotide transport and metabolism Dihydroorotate dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2284 804783 803449 -445
(445 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
SPAC57A10.12c [F] KOG1436 Dihydroorotate dehydrogenase 321 2e-87
Hs16753223 [F] KOG1436 Dihydroorotate dehydrogenase 283 3e-76
At5g23300 [F] KOG1436 Dihydroorotate dehydrogenase 263 3e-70
CE14420 [F] KOG1436 Dihydroorotate dehydrogenase 253 3e-67
7299059 [F] KOG1436 Dihydroorotate dehydrogenase 244 2e-64
>SPAC57A10.12c [F] KOG1436 Dihydroorotate dehydrogenase
Length = 443
Score = 321 bits (822), Expect = 2e-87
Identities = 188/419 (44%), Positives = 252/419 (59%), Gaps = 40/419 (9%)
Query: 42 YTVGIAIGSFAGFYFSNSRSAFHEYVLCPMLRLVTPDAEDGHKLGIWFLKNGLAPRLWFD 101
+T G+AI + S+ RS H + P+ T E H++ I G+ P+ D
Sbjct: 47 FTAGVAI-----YDMSDVRSFIHGRIEMPLFHAFTTP-EFSHRVAILAASWGITPK---D 97
Query: 102 N--DDKVLNVNIFGKKLTNPIGCAAGLDKNGDAIDGILSGGFGYIEIGSVTPLPQPGNPR 159
DD L V ++GKK NPIG AAG DK DAI G+L+ GF Y+EIGSVTP PQPGNP+
Sbjct: 98 RVADDPSLAVEVWGKKFCNPIGLAAGFDKQADAISGLLNFGFSYLEIGSVTPKPQPGNPK 157
Query: 160 PRFFRLPLDDAVINRYGFNSSGHDTVVNTLQSRITSFI-------------NSYMFKDNS 206
PR+FRL D +VINRYGFNS GHD ++ +Q R+ +I N D +
Sbjct: 158 PRYFRLKPDLSVINRYGFNSIGHDAILAKIQKRVRKYIAKTSPQLLKQFDANPASCTDPA 217
Query: 207 VENL--SLYKDKLLGVNLGKNKTGDEVQDYLKGVESFQKYADVLVINVSSPNTPGLRSLQ 264
V + SL +K LG+NLGKNK G+E++DY++GV +F +AD+LVINVSSPNTPGLR+LQ
Sbjct: 218 VLGVPRSLIPNKFLGINLGKNKNGNEIEDYVEGVRTFGNFADILVINVSSPNTPGLRNLQ 277
Query: 265 KESILTDLLTQVVAKRDSLVTSGNALGAKTHKPPVLVKVAPDLVXXXXXXXXXXXXXXXV 324
K+S L+ LLT VV++R+ L + PPVLVK+APDL +
Sbjct: 278 KKSALSTLLTAVVSERNKL---------NSPHPPVLVKIAPDLNEEELTDIADVLKKCKI 328
Query: 325 DGIIISNTTIQRPTTLITEDSDLVSQAGGLSGXXXXXXXXXXXXTMAKYTKGSGLVLVGC 384
DG+I+ NTT+QRP TL + + V + GGLSG T+ K+ S + ++GC
Sbjct: 329 DGVIVGNTTVQRPKTL--KSTSHVEETGGLSGPPLKPIALNTLRTLRKHL-SSDIPIIGC 385
Query: 385 GGISSGADAIEFAKAGASMVELYTAYAYKGPGLIAKIKDETTELLKKENKTWSEIIGED 443
GGISSG DAIE+A+AGA+MV++YTA Y GP + KIK E LK K W +IIG++
Sbjct: 386 GGISSGKDAIEYARAGATMVQVYTALGYDGPVIAHKIKQEILAELK--GKRWVDIIGKE 442
>Hs16753223 [F] KOG1436 Dihydroorotate dehydrogenase
Length = 395
Score = 283 bits (725), Expect = 3e-76
Identities = 168/384 (43%), Positives = 222/384 (57%), Gaps = 29/384 (7%)
Query: 51 FAGFYFSNSRSAFHEYVLCPMLRLVTPDAEDGHKLGIWFLKNGLAPRLWFDNDDKVLNVN 110
FA + + F+ L P L+ + D E H+L + F GL PR F + D +L V
Sbjct: 24 FASYLMATGDERFYAEHLMPTLQGLL-DPESAHRLAVRFTSLGLLPRARFQDSD-MLEVR 81
Query: 111 IFGKKLTNPIGCAAGLDKNGDAIDGILSGGFGYIEIGSVTPLPQPGNPRPRFFRLPLDDA 170
+ G K NP+G AAG DK+G+A+DG+ GFG++EIGSVTP PQ GNPRPR FRLP D A
Sbjct: 82 VLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQA 141
Query: 171 VINRYGFNSSGHDTVVNTLQSRITSFINSYMFKDNSVENLSLYKDKL-LGVNLGKNKTG- 228
VINRYGFNS G V + L++R + L +D L LGVNLGKNKT
Sbjct: 142 VINRYGFNSHGLSVVEHRLRAR-------------QQKQAKLTEDGLPLGVNLGKNKTSV 188
Query: 229 DEVQDYLKGVESFQKYADVLVINVSSPNTPGLRSLQKESILTDLLTQVVAKRDSLVTSGN 288
D +DY +GV AD LV+NVSSPNT GLRSLQ ++ L LLT+V+ +RD L
Sbjct: 189 DAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGL----- 243
Query: 289 ALGAKTHKPPVLVKVAPDLVXXXXXXXXXXXXXXXVDGIIISNTTIQRPTTLITEDSDLV 348
+ H+P VLVK+APDL +DG+I++NTT+ RP L L
Sbjct: 244 ---RRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGL---QGALR 297
Query: 349 SQAGGLSGXXXXXXXXXXXXTMAKYTKGSGLVLVGCGGISSGADAIEFAKAGASMVELYT 408
S+ GGLSG M T+G + ++G GG+SSG DA+E +AGAS+V+LYT
Sbjct: 298 SETGGLSGKPLRDLSTQTIREMYALTQGR-VPIIGVGGVSSGQDALEKIRAGASLVQLYT 356
Query: 409 AYAYKGPGLIAKIKDETTELLKKE 432
A + GP ++ K+K E LLK++
Sbjct: 357 ALTFWGPPVVGKVKRELEALLKEQ 380
>At5g23300 [F] KOG1436 Dihydroorotate dehydrogenase
Length = 441
Score = 263 bits (673), Expect = 3e-70
Identities = 162/395 (41%), Positives = 220/395 (55%), Gaps = 31/395 (7%)
Query: 43 TVGIAIGSFAGFYFSNSRSAFHEYVLCPMLRLVTP-----DAEDGHKLGIWFLKNGLAPR 97
T+G+AI G Y S + A L ++V P DAE HKL + G PR
Sbjct: 58 TIGLAIAG--GAYVSTADEATFCGWLFNATKVVNPFFALLDAEFAHKLAVSAAARGWVPR 115
Query: 98 LWFDNDDKVLNVNIFGKKLTNPIGCAAGLDKNGDAIDGILSGGFGYIEIGSVTPLPQPGN 157
D +L + ++G+K +NPIG AAG DKN +A +G+L GFG++E+GSVTP+PQ GN
Sbjct: 116 EKRP-DPAILGLEVWGRKFSNPIGLAAGFDKNAEATEGLLGMGFGFVEVGSVTPVPQEGN 174
Query: 158 PRPRFFRLPLDDAVINRYGFNSSGHDTVVNTLQSRITSFINSYMFKDNSVENLSLYKD-- 215
P+PR FRL + A+INR GFNS G + + R+ + M + S + S D
Sbjct: 175 PKPRIFRLSQEGAIINRCGFNSEG----IVVVAKRLGAQHGKRMLAETSATSSSPSDDVK 230
Query: 216 -------KLLGVNLGKNKTG-DEVQDYLKGVESFQKYADVLVINVSSPNTPGLRSLQKES 267
+LGVNLGKNKT D DY++GV + +YAD LVINVSSPNT GLR LQ
Sbjct: 231 PGGKSGPGILGVNLGKNKTSEDAAADYVQGVHNLSQYADYLVINVSSPNTAGLRMLQGRK 290
Query: 268 ILTDLLTQVVAKRDSLVTSGNALGAKTHKPPVLVKVAPDLVXXXXXXXXXXXXXXXVDGI 327
L DL+ +V A RD + PP+LVK+APDL +DG+
Sbjct: 291 QLKDLVKKVQAARDEMQWGDEG------PPPLLVKIAPDLSRGELEDIAAVALALHLDGL 344
Query: 328 IISNTTIQRPTTLITEDSDLVSQAGGLSGXXXXXXXXXXXXTMAKYTKGSGLVLVGCGGI 387
IISNTT+ RP + ++ + ++ GGLSG M T+G + L+GCGG+
Sbjct: 345 IISNTTVSRPDAV--SNNPVATETGGLSGKPLFALSTNMLRDMYTLTRGK-IPLIGCGGV 401
Query: 388 SSGADAIEFAKAGASMVELYTAYAYKGPGLIAKIK 422
SSG DA + +AGA++V+LYT +AY GP LI +IK
Sbjct: 402 SSGEDAYKKIRAGATLVQLYTGFAYGGPALIPQIK 436
>CE14420 [F] KOG1436 Dihydroorotate dehydrogenase
Length = 411
Score = 253 bits (647), Expect = 3e-67
Identities = 173/434 (39%), Positives = 231/434 (52%), Gaps = 39/434 (8%)
Query: 17 NQSQFFVKNGMVPLKAGISGPKLLKYTVGIAIGSFAGFYFSNSRSAFHEYVLCPMLRLVT 76
N Q ++ + + P IS ++ GIA S+ F++ + PM+
Sbjct: 4 NAEQKYIYSKLPP--GAISKSTVIVLATGIA--SYTALELLYGSETFYKKAVMPMVHKFV 59
Query: 77 PDAEDGHKLGIWFLKNGLAPRL-WFDNDDKVLNVNIFGKKLTNPIGCAAGLDKNGDAIDG 135
D ED H+ + GL PR W + L +FG++ NPIG AAG DK+G AI
Sbjct: 60 -DGEDSHRWAVRAASWGLLPRFGWNRKEYPELKCELFGREFKNPIGLAAGFDKDGQAITQ 118
Query: 136 IL-SGGFGYIEIGSVTPLPQPGNPRPRFFRLPLDDAVINRYGFNSSGHDTVVNTLQSRIT 194
+ + GFG IEIGSVTP+PQPGN RPR FRL D+ VINRYGFNS G V ++S
Sbjct: 119 LAKNSGFGLIEIGSVTPIPQPGNNRPRVFRLLEDEGVINRYGFNSDGVGRVHQRVRSARD 178
Query: 195 SFI-NSYMFKDNSVENLSLYKDKLLGVNLGKNK-TGDEVQDYLKGVESFQKYADVLVINV 252
S++ SY + GVNLGKNK T D DY GV F + D LV+NV
Sbjct: 179 SWVPESYAY---------------FGVNLGKNKLTEDAKLDYEIGVNYFAPHCDYLVLNV 223
Query: 253 SSPNTPGLRSLQKESILTDLLTQVVAKRDSLVTSGNALGAKTHKPPVLVKVAPDLVXX-- 310
SSPNTPGLRS+QK+S L LL + V + +P V +K+APDL+
Sbjct: 224 SSPNTPGLRSMQKKSDLEKLL--------AYVHQALEMHKLEKQPQVFLKIAPDLIESEL 275
Query: 311 XXXXXXXXXXXXXVDGIIISNTTIQRPTTLITEDSDLVSQAGGLSGXXXXXXXXXXXXTM 370
+DGII+SNTTI RP L +E+ ++ GGLSG +
Sbjct: 276 KDIAQVVTNKKFAIDGIIVSNTTIARPDYLRSENK---TETGGLSGAPVREISTECVRKI 332
Query: 371 AKYTKGSGLVLVGCGGISSGADAIEFAKAGASMVELYTAYAYKGPGLIAKIKDETTELLK 430
K T G + ++GCGG+ SGADA E +AGAS+V+LY+A+ Y+G +I KIK E ELL+
Sbjct: 333 YKLTNGQ-IPIIGCGGVFSGADAYEKIRAGASLVQLYSAFVYEGFPVIGKIKRELVELLR 391
Query: 431 KENKTW-SEIIGED 443
K+ + SE IG D
Sbjct: 392 KDGFSHVSEAIGAD 405
>7299059 [F] KOG1436 Dihydroorotate dehydrogenase
Length = 405
Score = 244 bits (623), Expect = 2e-64
Identities = 155/394 (39%), Positives = 219/394 (55%), Gaps = 36/394 (9%)
Query: 56 FSNSRSAFHEYVLCPMLRLVTPDAEDGHKLGIWFLKNGLAPRLWFDNDDKVLNVNIFGKK 115
+ N F +V+ P +RL+ AE H+L + K L P + +DD+ L+ + FG+
Sbjct: 39 YKNQDQLFRTFVM-PAVRLLP--AEASHQLAVLACKYRLCPVSQY-HDDQNLHTSFFGRM 94
Query: 116 LTNPIGCAAGLDKNGDAIDGILSGGFGYIEIGSVTPLPQPGNPRPRFFRLPLDDAVINRY 175
L+NPIG AAG DKN +A+DG+ GFG+IE+G+VTP Q GNP+PR FRL D A+INRY
Sbjct: 95 LSNPIGIAAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAIINRY 154
Query: 176 GFNSSGHDTVVNTLQSRITSFINSYMFKDNSVENLSLYKDKLLGVNLGKNKTG-DEVQDY 234
GFNS GH V+ L+ EN + ++GVNLG+NKT + DY
Sbjct: 155 GFNSDGHQAVLQRLRLL------------RKKENF----NGVVGVNLGRNKTTMSPIADY 198
Query: 235 LKGVESFQKYADVLVINVSSPNTPGLRSLQKESILTDLLTQVVAKRDSLVTSGNALGAKT 294
++GV F AD LVINVSSPNT GLR +Q + L +LL QV + SL + N
Sbjct: 199 VQGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNV----- 253
Query: 295 HKPPVLVKVAPDLVXXXXXXX--XXXXXXXXVDGIIISNTTIQRPTTLITEDSDLVSQAG 352
P+L+K++PDL VDG+I+SNTT+ R E + L + G
Sbjct: 254 ---PILLKLSPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSREN---IEKNKLAEETG 307
Query: 353 GLSGXXXXXXXXXXXXTMAKYTKGSGLVLVGCGGISSGADAIEFAKAGASMVELYTAYAY 412
GLSG M + T G + ++G GG++SG DA E +AGAS V++YTA Y
Sbjct: 308 GLSGPPLKARSTEMIAQMYQLTDGK-IPIIGVGGVASGYDAYEKIEAGASYVQIYTALVY 366
Query: 413 KGPGLIAKIKDETTELLKKENKT-WSEIIGEDIK 445
+GP L+ IK E + L+ + T ++++G + K
Sbjct: 367 EGPALVEDIKAELSALITRLGHTNVADVVGTNSK 400
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.138 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,651,239
Number of Sequences: 60738
Number of extensions: 1095607
Number of successful extensions: 2529
Number of sequences better than 1.0e-05: 5
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2499
Number of HSP's gapped (non-prelim): 5
length of query: 445
length of database: 30,389,216
effective HSP length: 110
effective length of query: 335
effective length of database: 23,708,036
effective search space: 7942192060
effective search space used: 7942192060
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)