ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2301 good E KOG0068 Amino acid transport and metabolism D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2301 811996 810587 -470
(470 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YER081w [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 778 0.0
YIL074c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 772 0.0
SPCC4G3.01 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isom... 584 e-166
Hs5729974 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 195 1e-49
Hs14744596 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isom... 194 2e-49
7297831 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 190 3e-48
CE08497 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-... 176 5e-44
At1g17740 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 176 7e-44
At4g34200 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 170 4e-42
At3g19480 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isome... 160 4e-39
Hs4557497 [K] KOG0067 Transcription factor CtBP 129 7e-30
Hs4557499 [K] KOG0067 Transcription factor CtBP 125 1e-28
SPAC186.07c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-iso... 123 5e-28
Hs12746590 [K] KOG0067 Transcription factor CtBP 121 3e-27
At5g14780 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 121 3e-27
SPAC186.02c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-iso... 118 2e-26
7299709 [K] KOG0067 Transcription factor CtBP 118 2e-26
At1g79870 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 115 1e-25
7296684 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 106 9e-23
CE28436 [K] KOG0067 Transcription factor CtBP 103 6e-22
7298718 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 103 6e-22
SPACUNK4.10 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-... 102 1e-21
At1g12550 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 101 3e-21
Hs6912396 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 100 5e-21
YNL274c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 97 7e-20
SPBC1773.17c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D... 94 4e-19
At1g72190 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 92 2e-18
YOR388c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 91 3e-18
At1g68010 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 91 3e-18
At2g45630 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-is... 85 2e-16
7298717 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 79 2e-14
At1g01510 [K] KOG0067 Transcription factor CtBP 74 6e-13
Hs20557095 [K] KOG0067 Transcription factor CtBP 69 2e-11
YPL113c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 69 2e-11
YPL275w [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 65 3e-10
YGL185c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isom... 58 3e-08
Hs20545061 [K] KOG0067 Transcription factor CtBP 55 2e-07
>YER081w [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 469
Score = 778 bits (2009), Expect = 0.0
Identities = 386/464 (83%), Positives = 434/464 (93%)
Query: 7 INNLQDSFEAALNLSSSPGAVSTSPTQSFMNTLPHRINAAKQQKALKPFSTGDIKILLLE 66
INNLQ++F+ A+N+S SPGAV TSPTQSFMNT+P R+NA K K LKPFSTGD+KILLLE
Sbjct: 6 INNLQNTFQQAMNMSGSPGAVCTSPTQSFMNTVPQRLNAVKHPKILKPFSTGDMKILLLE 65
Query: 67 NVNQTAIEIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKHAKNLVV 126
NVNQTAI IF +QGYQVEF+KSSLPE ELIEKIKDVHAIGIRSKT+LT +L+HAKNLV
Sbjct: 66 NVNQTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSNVLQHAKNLVC 125
Query: 127 IGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGT 186
IGCFCIGTNQVDLD+A GIAVFNSPFSNSRSVAELVIAEII+LARQLGDRSIELHTGT
Sbjct: 126 IGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQLGDRSIELHTGT 185
Query: 187 WNKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTAKQVSTLN 246
WNKV+A CWEVRGKTLGIIGYGHIGSQLSVLAEA+G++VLYYDIVTIM+LGTA+QVSTL+
Sbjct: 186 WNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVSTLD 245
Query: 247 ELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKI 306
ELLN SDFVT HVPATPET+ +LS PQFAAMKDG+YVINASRGTVVDIP+LIQA++A KI
Sbjct: 246 ELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKI 305
Query: 307 AGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVAT 366
AGAALDVYP+EPAKNG G+F+D LN+WT++LVSLPN+ILTPHIGGSTEEAQSSIGIEVAT
Sbjct: 306 AGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVAT 365
Query: 367 ALTKYINEGNTVGAVNFPEVSLRALDLDQENTVRVLYIHQNVPGVLKTVNNILSNHNIEK 426
AL+KYINEGN+VG+VNFPEV+L++L DQENTVRVLYIHQNVPGVLKTVN+ILSNHNIEK
Sbjct: 366 ALSKYINEGNSVGSVNFPEVALKSLSYDQENTVRVLYIHQNVPGVLKTVNDILSNHNIEK 425
Query: 427 QFSDSNGDIAYLMADISNVNQSDIKQIYDELNETDYKISIRLLY 470
QFSDSNG+IAYLMADIS+V+QSDIK IY++LN+T KISIRLLY
Sbjct: 426 QFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQTSAKISIRLLY 469
>YIL074c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 469
Score = 772 bits (1994), Expect = 0.0
Identities = 384/463 (82%), Positives = 433/463 (92%)
Query: 8 NNLQDSFEAALNLSSSPGAVSTSPTQSFMNTLPHRINAAKQQKALKPFSTGDIKILLLEN 67
+NLQDSF+ A+N S SPGAVSTSPTQSFMNTLP R++ KQ KALKPFSTGD+ ILLLEN
Sbjct: 7 DNLQDSFQRAMNFSGSPGAVSTSPTQSFMNTLPRRVSITKQPKALKPFSTGDMNILLLEN 66
Query: 68 VNQTAIEIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKHAKNLVVI 127
VN TAI+IF QGYQVEFHKSSLPE ELIEKIKDVHAIGIRSKT+LT +IL+HA+NLV I
Sbjct: 67 VNATAIKIFKDQGYQVEFHKSSLPEDELIEKIKDVHAIGIRSKTRLTEKILQHARNLVCI 126
Query: 128 GCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTW 187
GCFCIGTNQVDL +AA GIAVFNSPFSNSRSVAELVI EII+LARQLGDRSIELHTGTW
Sbjct: 127 GCFCIGTNQVDLKYAASKGIAVFNSPFSNSRSVAELVIGEIISLARQLGDRSIELHTGTW 186
Query: 188 NKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTAKQVSTLNE 247
NKV+A CWEVRGKTLGIIGYGHIGSQLSVLAEA+G++VLYYDIVTIM+LGTA+QVSTL+E
Sbjct: 187 NKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIVTIMALGTARQVSTLDE 246
Query: 248 LLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIA 307
LLN SDFVT HVPATPET+ +LS PQFAAMKDG+YVINASRGTVVDIP+LIQA++A KIA
Sbjct: 247 LLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTVVDIPSLIQAVKANKIA 306
Query: 308 GAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATA 367
GAALDVYP+EPAKNG G+F+D LN+WT++LVSLPN+ILTPHIGGSTEEAQSSIGIEVATA
Sbjct: 307 GAALDVYPHEPAKNGEGSFNDELNSWTSELVSLPNIILTPHIGGSTEEAQSSIGIEVATA 366
Query: 368 LTKYINEGNTVGAVNFPEVSLRALDLDQENTVRVLYIHQNVPGVLKTVNNILSNHNIEKQ 427
L+KYINEGN+VG+VNFPEVSL++LD DQENTVRVLYIH+NVPGVLKTVN+ILS+HNIEKQ
Sbjct: 367 LSKYINEGNSVGSVNFPEVSLKSLDYDQENTVRVLYIHRNVPGVLKTVNDILSDHNIEKQ 426
Query: 428 FSDSNGDIAYLMADISNVNQSDIKQIYDELNETDYKISIRLLY 470
FSDS+G+IAYLMADIS+VNQS+IK IY++LN+T K+SIRLLY
Sbjct: 427 FSDSHGEIAYLMADISSVNQSEIKDIYEKLNQTSAKVSIRLLY 469
>SPCC4G3.01 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 466
Score = 584 bits (1505), Expect = e-166
Identities = 290/457 (63%), Positives = 366/457 (79%), Gaps = 5/457 (1%)
Query: 19 NLSSSPGAVSTSPTQSFMNTLPHRINAAKQQ-----KALKPFSTGDIKILLLENVNQTAI 73
N+ S +S SP + + L + K + LKPF++ DIKILLLENVNQ+A+
Sbjct: 10 NVEDSLNKLSLSPPDNNSSFLSNHFQVRKSYSQAPARTLKPFASEDIKILLLENVNQSAL 69
Query: 74 EIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKHAKNLVVIGCFCIG 133
+GYQVEF K+S+ E +L+EKIK VHAIGIRSKT+LT +L+ A +L+VIGCFCIG
Sbjct: 70 SNLKDEGYQVEFLKTSMSEDDLVEKIKGVHAIGIRSKTRLTRRVLEAADSLIVIGCFCIG 129
Query: 134 TNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAA 193
TNQVDLDFAA+ GIAVFNSP++NSRSVAELVI II+LARQ+GDRS+ELH G WNKVS+
Sbjct: 130 TNQVDLDFAAERGIAVFNSPYANSRSVAELVIGYIISLARQVGDRSLELHRGEWNKVSSG 189
Query: 194 CWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTAKQVSTLNELLNNSD 253
CWE+RGKTLGIIGYGHIGSQLSVLAEA+G++V+YYDI+ IM LG+AKQ+S+L ELL+ +D
Sbjct: 190 CWEIRGKTLGIIGYGHIGSQLSVLAEAMGLHVVYYDILPIMPLGSAKQLSSLPELLHRAD 249
Query: 254 FVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDV 313
FV+ HVPA+PETKN++S +FAAMK+GSY+INASRGTVVDIPAL+ A ++GKIAGAA+DV
Sbjct: 250 FVSLHVPASPETKNMISSKEFAAMKEGSYLINASRGTVVDIPALVDASKSGKIAGAAIDV 309
Query: 314 YPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKYIN 373
YP+EPA NG F D+LN+WT++L N+ILTPHIGGSTEEAQ +IGIEV+ ALT+YIN
Sbjct: 310 YPSEPAGNGKDKFVDSLNSWTSELTHCKNIILTPHIGGSTEEAQYNIGIEVSEALTRYIN 369
Query: 374 EGNTVGAVNFPEVSLRALDLDQENTVRVLYIHQNVPGVLKTVNNILSNHNIEKQFSDSNG 433
EGN++GAVNFPEVSLR+L N RVL++H+NVPGVL+ VN + +HNI+ QFSDS G
Sbjct: 370 EGNSIGAVNFPEVSLRSLTEADRNAARVLFVHRNVPGVLRQVNELFIDHNIKSQFSDSRG 429
Query: 434 DIAYLMADISNVNQSDIKQIYDELNETDYKISIRLLY 470
DIAYL+ADIS+ ++ ++ +L KI+ RLLY
Sbjct: 430 DIAYLVADISDCTPGSLEALHQKLESLPCKINTRLLY 466
>Hs5729974 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 533
Score = 195 bits (496), Expect = 1e-49
Identities = 117/324 (36%), Positives = 176/324 (54%), Gaps = 16/324 (4%)
Query: 61 KILLLENVNQTAIEIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKH 120
K+L+ ++++ +I + G QV K +L + ELI +++D + +RS TK+T +++
Sbjct: 8 KVLISDSLDPCCRKILQEGGLQV-VEKQNLSKEELIAELQDCEGLIVRSATKVTADVINA 66
Query: 121 AKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSI 180
A+ L V+G G + VDL+ A + GI V N+P NS S AEL I+ LARQ+ +
Sbjct: 67 AEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATA 126
Query: 181 ELHTGTWNKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYD--IVTIMSLGT 238
+ G W + E+ GKTLGI+G G IG +++ ++ GM + YD I +S
Sbjct: 127 SMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASF 186
Query: 239 AKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALI 298
Q L E+ DF+T H P P T LL+ FA K G V+N +RG +VD AL+
Sbjct: 187 GVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALL 246
Query: 299 QAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQS 358
+A+++G+ AGAALDV+ EP ++ A LV NVI PH+G ST+EAQS
Sbjct: 247 RALQSGQCAGAALDVFTEEPPRDRA-------------LVDHENVISCPHLGASTKEAQS 293
Query: 359 SIGIEVATALTKYINEGNTVGAVN 382
G E+A + + G VN
Sbjct: 294 RCGEEIAVQFVDMVKGKSLTGVVN 317
>Hs14744596 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 533
Score = 194 bits (494), Expect = 2e-49
Identities = 117/324 (36%), Positives = 175/324 (53%), Gaps = 16/324 (4%)
Query: 61 KILLLENVNQTAIEIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKH 120
K+L+ ++++ +I G QV K +L + ELI +++D + +RS TK+T +++
Sbjct: 8 KVLISDSLDPCCRKILQDGGLQV-VEKQNLSKEELIAELQDCEGLIVRSATKVTADVINA 66
Query: 121 AKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSI 180
A+ L V+G G + VDL+ A + GI V N+P NS S AEL I+ LARQ+ +
Sbjct: 67 AEKLQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQATA 126
Query: 181 ELHTGTWNKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYD--IVTIMSLGT 238
+ G W + E+ GKTLGI+G G IG +++ ++ GM + YD I +S
Sbjct: 127 SMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSASF 186
Query: 239 AKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALI 298
Q L E+ DF+T H P P T LL+ FA K G V+N +RG +VD AL+
Sbjct: 187 GVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALL 246
Query: 299 QAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQS 358
+A+++G+ AGAALDV+ EP ++ A LV NVI PH+G ST+EAQS
Sbjct: 247 RALQSGQCAGAALDVFTEEPPRDRA-------------LVDHENVISCPHLGASTKEAQS 293
Query: 359 SIGIEVATALTKYINEGNTVGAVN 382
G E+A + + G VN
Sbjct: 294 RCGEEIAVQFVDMVKGKSLTGVVN 317
>7297831 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 332
Score = 190 bits (483), Expect = 3e-48
Identities = 107/308 (34%), Positives = 171/308 (54%), Gaps = 14/308 (4%)
Query: 61 KILLLENVNQTAIEIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKH 120
K+L+ + V+++ +E+ + G +V + K LP EL +++K+ A +RS TK+T E+L
Sbjct: 7 KVLVCDAVDKSCVELLEQHGIKVTY-KLKLPVEELCQEVKNFDAAIVRSDTKITAEVLAA 65
Query: 121 AK-NLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRS 179
+L V+G G + +D+ A + V N+P NS S EL I +LAR +
Sbjct: 66 GSGSLKVVGRAGAGVDNIDVPAATAQNVVVLNTPGGNSISACELTCILIGSLARPVVPAG 125
Query: 180 IELHTGTWNKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTA 239
+ G W++ A E+ GKTL ++G G IG ++++ + GM ++ YD +T + A
Sbjct: 126 QSMKEGRWDRKLYAGTELYGKTLAVLGLGRIGREVAIRMKTWGMRIIGYDPITTEAEAKA 185
Query: 240 KQVS--TLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPAL 297
+ TL E+ +D++T H P P T+NL+S A K G V+N +RG ++D A+
Sbjct: 186 AGIEKMTLEEIWPLADYITVHTPLIPATRNLISAETLAKCKQGVKVVNVARGGIIDEQAV 245
Query: 298 IQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQ 357
+ + +GK+AGAA DVYP EP K+ T L+S P V+ TPH+G ST EAQ
Sbjct: 246 LDGLESGKVAGAAFDVYPEEPPKSAV----------TKALISHPKVVATPHLGASTSEAQ 295
Query: 358 SSIGIEVA 365
+ +EVA
Sbjct: 296 VRVAVEVA 303
>CE08497 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 322
Score = 176 bits (447), Expect = 5e-44
Identities = 105/329 (31%), Positives = 179/329 (53%), Gaps = 18/329 (5%)
Query: 61 KILLLENVNQTAIEIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILK- 119
K+L+ +++ Q ++I + G +V K+ + EL+ + A+ +RS TK+T E+L
Sbjct: 7 KVLIADDIEQECVDILKQNGIEVTV-KTKQTKDELLVTLPQHDAVIVRSATKITAELLAA 65
Query: 120 HAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRS 179
A L ++G G + +D+ A+ + I V N+P +NSRS AEL I++L+R + +
Sbjct: 66 SAGKLKLVGRAGTGVDNIDVPAASANKILVMNTPQANSRSAAELTCTLILSLSRHVPQAA 125
Query: 180 IELHTGTWNKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTA 239
+ G W + EV G+TL ++G G IGS+++V +A GM V+ +D + A
Sbjct: 126 ASMKAGKWARKDFMGEEVYGRTLAVLGLGRIGSEVAVRLQAFGMKVIGFDPMVTKEQAEA 185
Query: 240 KQVS--TLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPAL 297
K + +L ++ +D++T HVP +T+NL++ A K G +IN +RG +V+ L
Sbjct: 186 KNIELLSLEQIWPQADYITVHVPLIKQTENLINKETLAKCKKGVRIINVARGGIVNEVDL 245
Query: 298 IQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQ 357
++++ AG GAA DV+ EP +L+ P VI TPH+G ST +AQ
Sbjct: 246 VESLNAGHAKGAAFDVFEQEPPT-------------FRELIDHPLVIATPHLGASTIDAQ 292
Query: 358 SSIGIEVATALTKYINEGNTVGAVNFPEV 386
+ E+A + +Y N+G +G +N EV
Sbjct: 293 LRVASEIADNIVQY-NKGTMLGVLNAREV 320
>At1g17740 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 624
Score = 176 bits (446), Expect = 7e-44
Identities = 109/334 (32%), Positives = 182/334 (53%), Gaps = 17/334 (5%)
Query: 61 KILLLENVNQTAIEIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKH 120
+IL+ E + + + + + G V+ PE +L +K+ + A+ +RS TK+T E+ +
Sbjct: 84 RILVTEKLGEAGVNLLREFG-DVDCSYDLSPE-DLKKKVAESDALIVRSGTKVTREVFEA 141
Query: 121 AKN-LVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRS 179
AK L V+G +G + VDL A +HG V N+P +N+ + AE IA + ++AR +
Sbjct: 142 AKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVAQAD 201
Query: 180 IELHTGTWNKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTA 239
+ G W + + GKTL ++G+G +G++++ A+ LGM V+ +D A
Sbjct: 202 ASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADRARA 261
Query: 240 KQVS--TLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPAL 297
V + ++ ++ +DFV+ H+P TP TK + + F+ MK G +IN +RG V+D AL
Sbjct: 262 LGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDEDAL 321
Query: 298 IQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQ 357
++A+ AG +A AALDV+ EP + L+ NV +TPH+G ST+EAQ
Sbjct: 322 VRALDAGIVAQAALDVFCEEPPSK------------DSRLIQHENVTVTPHLGASTKEAQ 369
Query: 358 SSIGIEVATALTKYINEGNTVGAVNFPEVSLRAL 391
+ IE+A A+ + + AVN P V+ L
Sbjct: 370 EGVAIEIAEAVAGALKGELSATAVNAPMVAPEVL 403
>At4g34200 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 603
Score = 170 bits (431), Expect = 4e-42
Identities = 123/377 (32%), Positives = 187/377 (48%), Gaps = 27/377 (7%)
Query: 21 SSSPGAVSTSPTQSFMNTLPHRINAAKQQKALKPFSTGDIK---ILLLENVNQTAIEIFN 77
S P A+S + NTL R+ L STGD IL+ E + I++
Sbjct: 27 SPLPSAISVAFPSRGRNTLQRRL-------VLVSCSTGDGSKPTILVAEKLGDAGIKLLE 79
Query: 78 KQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKHAKN-LVVIGCFCIGTNQ 136
V+ + PE EL KI A+ +RS TK+ E+ + + L V+G +G +
Sbjct: 80 DVA-NVDCSYNMTPE-ELNIKISLCDALIVRSGTKVGREVFESSHGRLKVVGRAGVGIDN 137
Query: 137 VDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAACWE 196
VDL A + G V N+P +N+ + AE IA + +AR + + G W +
Sbjct: 138 VDLSAATEFGCLVVNAPTANTIAAAEHGIALMAAMARNVAQADASVKAGEWKRNKYVGVS 197
Query: 197 VRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTAKQVS--TLNELLNNSDF 254
+ GKTL ++G+G +G++++ A+ LGM V+ +D A V + +E L +DF
Sbjct: 198 LVGKTLAVLGFGKVGTEVARRAKGLGMRVIAHDPYAPADRAHAIGVDLVSFDEALATADF 257
Query: 255 VTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVY 314
++ H+P TP T +L+ FA MK G ++N +RG V+D AL++A+ AG +A AALDV+
Sbjct: 258 ISLHMPLTPTTSKILNDETFAKMKKGVRIVNVARGGVIDEDALVRALDAGIVAQAALDVF 317
Query: 315 PNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKYINE 374
EP + LV V +TPH+G ST EAQ + IE+A A+ +N
Sbjct: 318 TKEPPAK------------DSKLVQHERVTVTPHLGASTMEAQEGVAIEIAEAVVGALNG 365
Query: 375 GNTVGAVNFPEVSLRAL 391
AVN P VS L
Sbjct: 366 ELAATAVNAPMVSAEVL 382
>At3g19480 [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 588
Score = 160 bits (405), Expect = 4e-39
Identities = 119/381 (31%), Positives = 189/381 (49%), Gaps = 23/381 (6%)
Query: 17 ALNLSS---SPGAVSTSPTQSFMNTLPHRINAAKQQKALKPFSTGDIKILLLENVNQTAI 73
+LNLSS S + T+P+ F RI + G IL+ E + Q I
Sbjct: 4 SLNLSSIFSSSSRLVTTPSSVFPIRQRRRIILVTSSSS---GGGGKPTILVTEKLGQAGI 60
Query: 74 EIFNKQGYQVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKHAKN-LVVIGCFCI 132
++ K + SL E L KI A+ +RS TK+ ++ + ++ L V+G +
Sbjct: 61 DLLKKYANVDCSYDLSLEE--LCTKISLCDALIVRSGTKVGRDVFESSRGRLKVVGRAGV 118
Query: 133 GTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSA 192
G + VDL A ++G V N+P +N+ + AE IA + +AR + + G W +
Sbjct: 119 GIDNVDLAAATEYGCLVVNAPTANTVAAAEHGIALLTAMARNIAQADASIKAGKWTRNKY 178
Query: 193 ACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTA--KQVSTLNELLN 250
+ GKTL ++G+G +GS+++ A LGM+V+ +D A ++ + ++
Sbjct: 179 VGVSLVGKTLAVLGFGKVGSEVARRARGLGMHVITHDPYAPADRARAIGVELVSFEVAIS 238
Query: 251 NSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAA 310
+DF++ H+P T T +++ FA MK G ++N +RG V+D AL++A+ +G +A AA
Sbjct: 239 TADFISLHLPLTAATSKMMNDVTFAMMKKGVRIVNVARGGVIDEEALLRALDSGIVAQAA 298
Query: 311 LDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTK 370
LDV+ EP DN LV +V TPH+G ST EAQ + IEVA A+
Sbjct: 299 LDVFTVEP------PVKDN------KLVLHESVTATPHLGASTMEAQEGVSIEVAEAVIG 346
Query: 371 YINEGNTVGAVNFPEVSLRAL 391
+ AVN P V L L
Sbjct: 347 ALRGELAATAVNAPMVPLEVL 367
>Hs4557497 [K] KOG0067 Transcription factor CtBP
Length = 440
Score = 129 bits (325), Expect = 7e-30
Identities = 89/270 (32%), Positives = 137/270 (49%), Gaps = 21/270 (7%)
Query: 113 LTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLA 172
LT E L+ K L +I G + +D+ A GIAV N P ++ A+ + I+ L
Sbjct: 81 LTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLY 140
Query: 173 RQLGDRSIELHTGTW-------NKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNV 225
R+ L GT +V++ +RG+TLGIIG G +G +++ A+A G NV
Sbjct: 141 RRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNV 200
Query: 226 LYYDIVTIMSLGTA---KQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSY 282
L+YD + A ++VSTL +LL +SD VT H +L++ M+ G++
Sbjct: 201 LFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAF 260
Query: 283 VINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPN 342
++N +RG +VD AL QA++ G+I GAALDV+ +EP G D PN
Sbjct: 261 LVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKD-----------APN 309
Query: 343 VILTPHIGGSTEEAQSSIGIEVATALTKYI 372
+I TPH +E+A + E A + + I
Sbjct: 310 LICTPHAAWYSEQASIEMREEAAREIRRAI 339
>Hs4557499 [K] KOG0067 Transcription factor CtBP
Length = 445
Score = 125 bits (314), Expect = 1e-28
Identities = 91/271 (33%), Positives = 137/271 (49%), Gaps = 23/271 (8%)
Query: 113 LTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLA 172
LT E L+ K L VI G + VD+ A + GIAV N P + A+ I I+ L
Sbjct: 87 LTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLY 146
Query: 173 RQLGDRSIELHTGTW-------NKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNV 225
R+ L GT +V++ +RG+TLG+IG+G G ++V A+A G +V
Sbjct: 147 RRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSV 206
Query: 226 LYYDIVTI----MSLGTAKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGS 281
++YD SLG ++V TL +LL SD V+ H +L++ M+ G+
Sbjct: 207 IFYDPYLQDGIERSLGV-QRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGA 265
Query: 282 YVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLP 341
+++NA+RG +VD AL QA++ G+I GAALDV+ +EP G D P
Sbjct: 266 FLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKD-----------AP 314
Query: 342 NVILTPHIGGSTEEAQSSIGIEVATALTKYI 372
N+I TPH +E+A + AT + + I
Sbjct: 315 NLICTPHTAWYSEQASLEMREAAATEIRRAI 345
>SPAC186.07c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 332
Score = 123 bits (309), Expect = 5e-28
Identities = 93/303 (30%), Positives = 154/303 (50%), Gaps = 10/303 (3%)
Query: 81 YQVEFHKSSLPE--AELIEKIKDVHAIGIRSKTKLTPEILKH-AKN-LVVIGCFCIGTNQ 136
+++++H+S L + A L EK + + K+ + LK AKN +I C G N
Sbjct: 25 HEIDYHESILNKKTAVLAEKAP---VVCVFVNDKVDADTLKVLAKNGTKLIALRCAGFNN 81
Query: 137 VDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAACWE 196
VDL AA +GI V P + +VAE I +++L R++ + + +N +
Sbjct: 82 VDLKAAADNGITVVRVPAYSPYAVAEYTIGLLLSLNRKIHRAYVRVREDDFNLNGLLGHD 141
Query: 197 VRGKTLGIIGYGHIGSQLS-VLAEALGMNVLYYDIVTIMSLGT-AKQVSTLNELLNNSDF 254
+ GKT+G++G G IG ++ L G VL +DI L Q E+L +DF
Sbjct: 142 LHGKTIGLLGTGRIGGLVAKCLKLGFGCEVLAHDIKPNKELEKFGIQFVEQQEVLAKADF 201
Query: 255 VTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVY 314
+ H P TP+T++L+ A+MK G +IN SRG +VD AL++A+ +G++ G A+DVY
Sbjct: 202 LCLHCPLTPDTEHLVDEKLLASMKKGVKIINTSRGGLVDTKALVKAIESGQVGGCAMDVY 261
Query: 315 PNEPAKNGAGAFSDNL-NTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKYIN 373
E ++ + +T L + PNV++T H T EA S+I ++ + +
Sbjct: 262 EGERRLFYRDLSNEVIKDTTFQQLANFPNVLVTSHQAFFTAEALSAIAHTTLKNVSDFAS 321
Query: 374 EGN 376
+ N
Sbjct: 322 QNN 324
>Hs12746590 [K] KOG0067 Transcription factor CtBP
Length = 985
Score = 121 bits (303), Expect = 3e-27
Identities = 94/292 (32%), Positives = 146/292 (49%), Gaps = 26/292 (8%)
Query: 94 ELIEKIKDVHAIGIRSKTKLT--PEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFN 151
E+ EK+ + A+G +T E L+ K L VI G + V++ A + GIAV N
Sbjct: 607 EIHEKVLN-EAVGAMMYHTITFNREDLEKFKALRVIVRIGSGYDNVNIKAAGELGIAVCN 665
Query: 152 SPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTW-------NKVSAACWEVRGKTLGI 204
P + A+ I I+ L R+ L GT +V++ +RG+TLG+
Sbjct: 666 IPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGL 725
Query: 205 IGYGHIGSQLSVLAEALGMNVLYYDIVTI----MSLGTAKQVSTLNELLNNSDFVTCHVP 260
IG+G G ++V A+A G +V++YD SLG ++V TL +LL SD V+ H
Sbjct: 726 IGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGV-QRVYTLQDLLYQSDCVSLHCN 784
Query: 261 ATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAK 320
+L++ M+ G++++NA+RG +VD AL QA++ G+I GAALDV+ +EP
Sbjct: 785 LNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFS 844
Query: 321 NGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKYI 372
G D PN+I TPH +E+A + AT + + I
Sbjct: 845 FAQGPLKD-----------APNLICTPHTAWYSEQASLEMREAAATEIRRAI 885
>At5g14780 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 384
Score = 121 bits (303), Expect = 3e-27
Identities = 85/289 (29%), Positives = 139/289 (47%), Gaps = 20/289 (6%)
Query: 91 PEAELIEKIKDVHAIGIRS--KTKLTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIA 148
P+ EL + I D+H + +T E +K AKNL ++ IG++ +DL AA G+
Sbjct: 85 PDCELEKHIPDLHVLISTPFHPAYVTAERIKKAKNLKLLLTAGIGSDHIDLQAAAAAGLT 144
Query: 149 VFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAA--CWEVRGKTLGIIG 206
V SN SVAE + I+ L R ++ G WN A +++ GKT+G +G
Sbjct: 145 VAEVTGSNVVSVAEDELMRILILMRNFVPGYNQVVKGEWNVAGIAYRAYDLEGKTIGTVG 204
Query: 207 YGHIGSQLSVLAEALGMNVLYYDIVTIM----SLGTAKQVSTLNELLNNSDFVTCHVPAT 262
G IG L + G N+LY+D + + AK V LNE+L D + ++P T
Sbjct: 205 AGRIGKLLLQRLKPFGCNLLYHDRLQMAPELEKETGAKFVEDLNEMLPKCDVIVINMPLT 264
Query: 263 PETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNG 322
+T+ + + +K G ++N +RG +++ A++ A+ +G I G + DV+ +PA
Sbjct: 265 EKTRGMFNKELIGKLKKGVLIVNNARGAIMERQAVVDAVESGHIGGYSGDVWDPQPAPKD 324
Query: 323 AGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKY 371
+ W +PN +TPH G+T +AQ L +Y
Sbjct: 325 --------HPWR----YMPNQAMTPHTSGTTIDAQLRYAAGTKDMLERY 361
>SPAC186.02c [E] KOG0068 D-3-phosphoglycerate dehydrogenase D-isomer-specific
2-hydroxy acid dehydrogenase superfamily
Length = 332
Score = 118 bits (295), Expect = 2e-26
Identities = 75/233 (32%), Positives = 123/233 (52%), Gaps = 3/233 (1%)
Query: 131 CIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKV 190
C G N V+L A+++ I V + P + +V+E + +++L R++ + + +N V
Sbjct: 76 CGGYNNVNLKAASEYKITVVHVPSYSPFAVSEFTVGLLLSLNRKIHRAYVRVREDDFNIV 135
Query: 191 SAACWEVRGKTLGIIGYGHIGSQLSVLAE-ALGMNVLYYDIVTIMSLGT-AKQVSTLNEL 248
++ GKT+G+IG G IGS ++ + G +VL YDI L Q NE+
Sbjct: 136 GLLGCDIHGKTVGVIGTGKIGSNVAKCFKMGFGCDVLAYDINPDKKLENYGVQFVEQNEV 195
Query: 249 LNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAG 308
L +DF+ H P TP T ++++ A MK G ++N SRG ++D AL+ A+ +G++ G
Sbjct: 196 LKKADFLCLHCPLTPSTTHIVNSDSLALMKKGVTIVNTSRGGLIDTKALVDAIDSGQVGG 255
Query: 309 AALDVYPNEPAKNGAGAFSDNLNTWTTD-LVSLPNVILTPHIGGSTEEAQSSI 360
A+DVY E ++ + T LV+ PNV++T H T EA SI
Sbjct: 256 CAIDVYEGERNLFYKDLSNEVIKDSTFQRLVNFPNVLVTSHQAFFTTEALCSI 308
>7299709 [K] KOG0067 Transcription factor CtBP
Length = 386
Score = 118 bits (295), Expect = 2e-26
Identities = 90/271 (33%), Positives = 136/271 (49%), Gaps = 23/271 (8%)
Query: 113 LTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLA 172
LT E L+ K L +I GT+ +D+ A + GIAV N P VA+ + I+ L
Sbjct: 81 LTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLY 140
Query: 173 RQ---LGD--RSIELHTGTWNKVSAA--CWEVRGKTLGIIGYGHIGSQLSVLAEALGMNV 225
R+ L + R + TG AA C +RG TLG++G G IGS +++ A+A G NV
Sbjct: 141 RRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNV 200
Query: 226 LYYDIVTI----MSLGTAKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGS 281
++YD SLG + V TL +LL SD V+ H +L++ M+ G+
Sbjct: 201 IFYDPYLPDGIDKSLGLTR-VYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGA 259
Query: 282 YVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLP 341
+++N +RG +VD L A++ G+I AALDV+ NEP GA D P
Sbjct: 260 FLVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYNVFQGALKD-----------AP 308
Query: 342 NVILTPHIGGSTEEAQSSIGIEVATALTKYI 372
N+I TPH ++ + + + AT + + I
Sbjct: 309 NLICTPHAAFFSDASATELREMAATEIRRAI 339
>At1g79870 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 313
Score = 115 bits (289), Expect = 1e-25
Identities = 75/246 (30%), Positives = 123/246 (49%), Gaps = 15/246 (6%)
Query: 116 EILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQL 175
+++ NL ++ F +G +++DL + GI V N+P + VA+L I I+ L R+L
Sbjct: 60 QLISDLPNLEIVSSFSVGLDKIDLGKCKEKGIRVTNTPDVLTEDVADLAIGLILALLRRL 119
Query: 176 GDRSIELHTGTWNKVS-AACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIM 234
+ + +G W + + GK++GIIG G IG+ ++ AEA + YY TI
Sbjct: 120 CECDRYVRSGKWKQGEFQLTTKFSGKSVGIIGLGRIGTAIAKRAEAFSCPINYYSR-TIK 178
Query: 235 SLGTAKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDI 294
K T+ +L NSD + P T +T++++ A+ +IN RG VD
Sbjct: 179 PDVAYKYYPTVVDLAQNSDILVVACPLTEQTRHIVDRQVMDALGAKGVLINIGRGPHVDE 238
Query: 295 PALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTE 354
LI+A+ G++ GAALDV+ EP +L L NV+L PH+G T
Sbjct: 239 QELIKALTEGRLGGAALDVFEQEPHV-------------PEELFGLENVVLLPHVGSGTV 285
Query: 355 EAQSSI 360
E ++++
Sbjct: 286 ETRNAM 291
>7296684 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 325
Score = 106 bits (264), Expect = 9e-23
Identities = 82/307 (26%), Positives = 144/307 (46%), Gaps = 30/307 (9%)
Query: 67 NVNQTAIEIFNKQGYQVEFHKSS-LPEAELIEKIKDVHAIGIRSKTKLTPEILKHA-KNL 124
+V+ + +E+ K +H+++ +P +ELI + A+ K+ E+L A L
Sbjct: 13 DVDDSGLELLRKSCQVSTWHETNPVPRSELIRVVAGKDALYCALTDKVDKEVLDAAGPQL 72
Query: 125 VVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHT 184
+ +G + +D++ K GI V +P + + AEL +A ++ R+L + + +++
Sbjct: 73 KCVATISVGYDHIDVEECRKRGIRVGFTPDVLTDATAELTLALLLATNRRLFEANKQVYN 132
Query: 185 GTWNKVSAACWE----VRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTAK 240
G W K A W ++G +G++G+G IG +++ + Y T SL K
Sbjct: 133 GGW-KSWAPMWMCGQGLKGSRVGLLGFGRIGQEIAARIVPFKPTEITY---TTRSL-RPK 187
Query: 241 QVSTLN-------ELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVD 293
+ + +N E+L SD + TPETK + + F MK +IN +RG VVD
Sbjct: 188 EAAAVNARHVDFDEMLRESDLIVVCCALTPETKEIFNATAFQKMKPNCILINTARGGVVD 247
Query: 294 IPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGST 353
AL +A++ +I A LDV EP L+ L NV++ PHIG +
Sbjct: 248 QKALYEALKTKRILAAGLDVTTPEPL------------PIDDPLLKLDNVVILPHIGSAD 295
Query: 354 EEAQSSI 360
E + +
Sbjct: 296 IETRKEM 302
>CE28436 [K] KOG0067 Transcription factor CtBP
Length = 701
Score = 103 bits (257), Expect = 6e-22
Identities = 74/272 (27%), Positives = 128/272 (46%), Gaps = 20/272 (7%)
Query: 112 KLTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITL 171
KL E L+ K L V+ G + +D+ A + GIAV ++P VA+ ++ I+ L
Sbjct: 205 KLEKEDLEKFKVLKVVFRIGYGIDNIDVKAATELGIAVCHAPGDYVEDVADSTLSLILDL 264
Query: 172 -------ARQLGDRSIELHTGTWNKVSAACWEVRGKTLGIIGYGHIGSQLSVLAEALGMN 224
A+ + + + + +VRG LGI+G G +G+ + + A A G++
Sbjct: 265 FRRTYWHAKSYSETRKTIGADQVRENAVGSKKVRGSVLGILGCGRVGTAVGLRARAFGLH 324
Query: 225 VLYYDIVTIMSLGTA---KQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGS 281
+++YD A ++V T++E ++ SD ++ H ET+ +++ K G
Sbjct: 325 IIFYDPFVREGHDKALGFERVYTMDEFMSRSDCISLHCNLGDETRGIINADSLRQCKSGV 384
Query: 282 YVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLP 341
Y++N S +++ L A++ G + GAALDV+ + F N LV P
Sbjct: 385 YIVNTSHAGLINENDLAAALKNGHVKGAALDVHDSV-------RFDPNC---LNPLVGCP 434
Query: 342 NVILTPHIGGSTEEAQSSIGIEVATALTKYIN 373
N+I TPH TE + + I A + K IN
Sbjct: 435 NIINTPHSAWMTEASCKDLRINAAKEIRKAIN 466
>7298718 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 598
Score = 103 bits (257), Expect = 6e-22
Identities = 86/320 (26%), Positives = 148/320 (45%), Gaps = 26/320 (8%)
Query: 50 KALKPFSTGDIKILLLE-NVNQTAIEIFNKQGYQVE-FHKSSLPEAELIEKIKDVHAIGI 107
+ LK +T K+L+ +V IEI +Q ++ ++ E++EKI+ HA+
Sbjct: 268 EGLKMSTTKPFKVLIAHTDVPPEGIEILKEQCEILQVINEPPKNRPEILEKIRGAHAVIW 327
Query: 108 RSKTKLTPEILKHA-KNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIA 166
+ L EIL A L + G N VD+ K GI + ++P + +VA+L +
Sbjct: 328 GGRDILNAEILDAAGPQLKAVSTMSSGINNVDVPELKKRGIPLGSTPAMLTVAVADLTVG 387
Query: 167 EIITLARQLGDRSIELHTGTWNKVSAACW----EVRGKTLGIIGYGHIGSQLSVLAEALG 222
+I AR+ + ++ + W+K W ++R T+G G+G IG ++
Sbjct: 388 LLIAAARRFQEGRRKIDSDKWDK-DHLNWMLGQDIRDSTVGFYGFGGIGQAVAKRLMGFD 446
Query: 223 MNVLYYDIVTIMSLG-----TAKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAM 277
+ + Y +S AK+V LL SDF+ P T ET L + F M
Sbjct: 447 IKRMLYTTRNRVSQDIEERFNAKKVD-FETLLAESDFLIIASPLTKETLGLFNATVFNKM 505
Query: 278 KDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDL 337
K+ + ++N RG +V+ L +A+++ +I A LDV EP + L
Sbjct: 506 KETAVLVNVGRGKIVNQDDLYEALKSNRIFAAGLDVMDPEPLPS------------NDKL 553
Query: 338 VSLPNVILTPHIGGSTEEAQ 357
++L NV++TPH+G +T +
Sbjct: 554 LTLDNVVVTPHVGYATRRTR 573
Score = 63.2 bits (152), Expect = 8e-10
Identities = 52/205 (25%), Positives = 86/205 (41%), Gaps = 8/205 (3%)
Query: 91 PEAELIEKIKDVHAIGIRSKTKLTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVF 150
P EL+ + I +S EIL+ L + G + VD+ K GI +
Sbjct: 43 PALELLRS-RGAETIICQSVPPSRDEILQKVPGLRCVSTMSSGIDFVDIPEFQKRGIPLG 101
Query: 151 NSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAACW----EVRGKTLGIIG 206
++P +VA+L I +I R E+ W K+ W E+R +G G
Sbjct: 102 HTPGVVKNAVADLAIGLMIAAGRHFHAGRTEIERSQW-KIEQINWMMGQEIRDSVIGFFG 160
Query: 207 YGHIGSQLSVLAEALGM-NVLYYDIVTIMSLGTAK-QVSTLNELLNNSDFVTCHVPATPE 264
+G I ++ + + ++Y+ + G K + + +LL SDF+ P T E
Sbjct: 161 FGGISQAIAKRLQCWDVAKIIYHTRTRKENDGDFKAEHVSFEQLLQESDFLVVAAPLTNE 220
Query: 265 TKNLLSGPQFAAMKDGSYVINASRG 289
T+ +G F MK S +N +RG
Sbjct: 221 TREKFNGKAFNLMKRSSVFVNVARG 245
>SPACUNK4.10 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 334
Score = 102 bits (254), Expect = 1e-21
Identities = 64/226 (28%), Positives = 108/226 (47%), Gaps = 14/226 (6%)
Query: 133 GTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSA 192
G VD+ GI V + P + + A++ I ++ R ELH WN
Sbjct: 90 GYETVDVAACTARGIQVSHVPKAVDDATADVGIFLMLGALRGFNQGIFELHKNNWNANCK 149
Query: 193 ACWEVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMSL-GTAKQVSTLNELLNN 251
+ GKTLGI+G G IG ++ A A M ++Y++ + + + ++LL
Sbjct: 150 PSHDPEGKTLGILGLGGIGKTMAKRARAFDMKIVYHNRTPLPEEEAEGAEFVSFDDLLAK 209
Query: 252 SDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAAL 311
SD ++ ++P T++++ P+F MK G ++N +RG V+D AL++A+ G + A L
Sbjct: 210 SDVLSLNLPLNAHTRHIIGKPEFQKMKRGIVIVNTARGAVMDEAALVEALDEGIVYSAGL 269
Query: 312 DVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQ 357
DV+ EP + L+ VIL PH+G ++ E Q
Sbjct: 270 DVFEEEPKIH-------------PGLLENEKVILLPHLGTNSLETQ 302
>At1g12550 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 323
Score = 101 bits (251), Expect = 3e-21
Identities = 71/269 (26%), Positives = 127/269 (46%), Gaps = 17/269 (6%)
Query: 104 AIGIRSKTKLTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAEL 163
A I + +T E+L H +L ++ C +G + +DL + GI + N+ + S VA+
Sbjct: 55 AFVISGRLPVTDELLSHLPSLQILVCTSVGIDHIDLAACKRRGIVITNAGNAFSDDVADC 114
Query: 164 VIAEIITLARQLGDRSIELHTGTWNKVS--AACWEVRGKTLGIIGYGHIGSQLSVLAEAL 221
+ +I++ R++ + +G W K +V GK +GI+G G IGS ++ E+
Sbjct: 115 AVGLLISVLRRIPAADRYVRSGNWAKFGDFQLGSKVSGKRVGIVGLGSIGSFVAKRLESF 174
Query: 222 GMNVLYYDIVTIMSLGTAKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGS 281
G V+ Y+ + + S + L N+D + T ET ++++ +
Sbjct: 175 GC-VISYNSRSQKQSSPYRYYSDILSLAENNDVLVLCCSLTDETHHIVNREVMELLGKDG 233
Query: 282 YVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLP 341
VIN RG ++D +++ + G I GA LDV+ NEPA +L L
Sbjct: 234 VVINVGRGKLIDEKEMVKCLVDGVIGGAGLDVFENEPAV-------------PQELFGLD 280
Query: 342 NVILTPHIGGSTEEAQSSIGIEVATALTK 370
NV+L+PH +T + ++ ++A A K
Sbjct: 281 NVVLSPHFAVATPGSLDNVA-QIALANLK 308
>Hs6912396 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 328
Score = 100 bits (249), Expect = 5e-21
Identities = 81/286 (28%), Positives = 128/286 (44%), Gaps = 19/286 (6%)
Query: 90 LPEAELIEKIKDVHAIGIRSKTKLTPEILKHA-KNLVVIGCFCIGTNQVDLDFAAKHGIA 148
+P EL + H + + IL A NL VI +G + + LD K GI
Sbjct: 40 IPAKELERGVAGAHGLLCLLSDHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIR 99
Query: 149 VFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTG---TWNKVSAACWEVRGKTLGII 205
V +P + + AEL ++ ++T R+L + E+ G +W + + + T+GII
Sbjct: 100 VGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGII 159
Query: 206 GYGHIGSQLSVLAEALGMNVLYYDIVTIMSLGTAK---QVSTLNELLNNSDFVTCHVPAT 262
G G IG ++ + G+ Y A+ + + EL SDF+ T
Sbjct: 160 GLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLT 219
Query: 263 PETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNG 322
P T+ L + F MK+ + IN SRG VV+ L QA+ +GKIA A LDV EP
Sbjct: 220 PATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPT- 278
Query: 323 AGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATAL 368
L++L N ++ PHIG +T ++++ + A L
Sbjct: 279 -----------NHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNL 313
>YNL274c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 350
Score = 96.7 bits (239), Expect = 7e-20
Identities = 75/287 (26%), Positives = 133/287 (46%), Gaps = 25/287 (8%)
Query: 82 QVEFHKSSLPEAELIEKIKDVHAIGIRSKTKLTPEILKHAKNLVVIGCFC-IGTNQVDLD 140
+V+ ++ L + ++I + A +++ + E+ + VV C G +Q+D++
Sbjct: 44 EVKDPQNKLSQVQVITRT----ARSVKNTGRFDEELALALPSSVVAVCHTGAGYDQIDVE 99
Query: 141 FAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAAC-----W 195
K I V N P S + A+ + ++ R G + L G W + AC +
Sbjct: 100 PFKKRHIQVANVPDLVSNATADTHVFLLLGALRNFGIGNRRLIEGNWPEAGPACGSPFGY 159
Query: 196 EVRGKTLGIIGYGHIGSQLSVLAEALGM-NVLYYDIVTIMSLGT-AKQVSTLNELLNNSD 253
+ GKT+GI+G G IG + + G N +Y++ + S + E L SD
Sbjct: 160 DPEGKTVGILGLGRIGRCILERLKPFGFENFIYHNRHQLPSEEEHGCEYVGFEEFLKRSD 219
Query: 254 FVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDV 313
V+ +VP T +L++ MKDG ++N +RG V+D A+ A+R+GKI A LDV
Sbjct: 220 IVSVNVPLNHNTHHLINAETIEKMKDGVVIVNTARGAVIDEQAMTDALRSGKIRSAGLDV 279
Query: 314 YPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSI 360
+ EP + +L+S+ V+ PH+G + E + +
Sbjct: 280 FEYEP-------------KISKELLSMSQVLGLPHMGTHSVETRKKM 313
>SPBC1773.17c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 185
Score = 94.0 bits (232), Expect = 4e-19
Identities = 60/191 (31%), Positives = 98/191 (50%), Gaps = 20/191 (10%)
Query: 199 GKTLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTIMS-----LGTAKQVSTLNELLNNSD 253
GK +GIIG G IG + LG ++Y++ + + LG + + +ELL++SD
Sbjct: 4 GKRVGIIGMGAIGKSFAQKILPLGCEIVYHNRNRLEAEEEKRLGAS--FVSFDELLSSSD 61
Query: 254 FVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDV 313
++ + P TP T +L+S +F MKDG Y+IN +RG +++ A I+A+++GK+A A LDV
Sbjct: 62 VISINCPLTPATHDLISTKEFEKMKDGVYIINTARGAIINEDAFIKAIKSGKVARAGLDV 121
Query: 314 YPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKYIN 373
+ NEP N W + V + PH G T + V ++ +++
Sbjct: 122 FLNEPTPN---------KFW----LECDKVTIQPHCGVYTNFTVAKTEECVLASIETFLD 168
Query: 374 EGNTVGAVNFP 384
G VN P
Sbjct: 169 TGIPTNPVNGP 179
>At1g72190 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 344
Score = 91.7 bits (226), Expect = 2e-18
Identities = 74/301 (24%), Positives = 139/301 (45%), Gaps = 33/301 (10%)
Query: 97 EKIKDVHAIGIRSKTKLTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFS- 155
E IK+ H I + ++ ++ A N+ +I + +G + VD+D A KHGI V P
Sbjct: 61 EVIKNYH-ICVAMTMQMDSNVISRASNIKLIMQYGVGLDGVDIDAATKHGIKVARIPSEG 119
Query: 156 --NSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAACWEVRGKTLGIIGYGHIGSQ 213
N+ S +E+ I ++ L ++ + I L + + + GKT+ I+GYG+IG +
Sbjct: 120 TGNAASCSEMAIYLMLGLLKKQNEMQISLRNRLLGEPTGDT--LLGKTVFILGYGNIGIE 177
Query: 214 LSVLAEALGMNVLYY-----------DIVTIMSLGTAKQVSTLNELLNNSDFVTCHVPAT 262
L+ + G V+ D + G+ + + T +D V +
Sbjct: 178 LAKRLKPFGSRVIATKRFWPASIVDSDSRLVDEKGSHEDIYTF---AGKADIVVVCLRLN 234
Query: 263 PETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNG 322
ET +++ +MK G+ ++N +RG +++ + Q + +G + G +DV +EP
Sbjct: 235 KETAEIVNKEFICSMKKGALLVNIARGGLINYESAFQNLESGHLGGLGIDVAWSEP---- 290
Query: 323 AGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKYINEGNTVGAVN 382
F N ++ NVI+TPH+ G TE + S+ ++ L ++EG + +
Sbjct: 291 ---FDPN-----DPILKFKNVIITPHVAGVTEYSYRSMA-KIVGDLALQLHEGLPLTGIE 341
Query: 383 F 383
F
Sbjct: 342 F 342
>YOR388c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 376
Score = 91.3 bits (225), Expect = 3e-18
Identities = 86/333 (25%), Positives = 147/333 (43%), Gaps = 37/333 (11%)
Query: 69 NQTAIEIF-NKQGYQV--EFHKSSLPEAELIEKIKDVHAIGIRS--KTKLTPEILKHAKN 123
N+ I F +QGY++ K P + + ++KD + ++ + A N
Sbjct: 29 NELGIRNFIEEQGYELVTTIDKDPEPTSTVDRELKDAEIVITTPFFPAYISRNRIAEAPN 88
Query: 124 LVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELH 183
L + +G++ VDL+ A + I V SN SVAE V+A I+ L R +
Sbjct: 89 LKLCVTAGVGSDHVDLEAANERKITVTEVTGSNVVSVAEHVMATILVLIRNYNGGHQQAI 148
Query: 184 TGTWNKVSAAC--WEVRGKTLGIIGYGHIGSQLSVLAEALGMN---VLYYDIV-----TI 233
G W+ A +++ K + +G G IG + VL + N +LYYD I
Sbjct: 149 NGEWDIAGVAKNEYDLEDKIISTVGAGRIGYR--VLERLVAFNPKKLLYYDYQELPAEAI 206
Query: 234 MSLGTA-----------KQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSY 282
L A ++V L +++ SD VT + P +++ L + + MKDG+Y
Sbjct: 207 NRLNEASKLFNGRGDIVQRVEKLEDMVAQSDVVTINCPLHKDSRGLFNKKLISHMKDGAY 266
Query: 283 VINASRGTVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTW-TTDLVSLP 341
++N +RG + + +A+++GK+AG DV+ +PA + W T D
Sbjct: 267 LVNTARGAICVAEDVAEAVKSGKLAGYGGDVWDKQPAPKD--------HPWRTMDNKDHV 318
Query: 342 NVILTPHIGGSTEEAQSSIGIEVATALTKYINE 374
+T HI G++ +AQ V L Y ++
Sbjct: 319 GNAMTVHISGTSLDAQKRYAQGVKNILNSYFSK 351
>At1g68010 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 386
Score = 91.3 bits (225), Expect = 3e-18
Identities = 64/245 (26%), Positives = 116/245 (47%), Gaps = 35/245 (14%)
Query: 132 IGTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVS 191
+G N VD++ A K+GIAV N+P + + AEL + + AR++ + + G +
Sbjct: 95 VGYNNVDVEAANKYGIAVGNTPGVLTETTAELAASLSLAAARRIVEADEFMRGGLYEGWL 154
Query: 192 AACWE---VRGKTLGIIGYGHIGSQLS-VLAEALGMNVLYYDIVTIMSLG---------- 237
+ ++G+T+G+IG G IGS + ++ E MN++Y+D+ L
Sbjct: 155 PHLFVGNLLKGQTVGVIGAGRIGSAYARMMVEGFKMNLIYFDLYQSTRLEKFVTAYGQFL 214
Query: 238 --------TAKQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRG 289
T K+ S++ E+L +D ++ H T +L++ + A MK + ++N SRG
Sbjct: 215 KANGEQPVTWKRASSMEEVLREADLISLHPVLDKTTYHLVNKERLAMMKKEAILVNCSRG 274
Query: 290 TVVDIPALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHI 349
V+D AL++ ++ + LDV+ EP L N I+ PHI
Sbjct: 275 PVIDEAALVEHLKENPMFRVGLDVFEEEPFMK-------------PGLADTKNAIVVPHI 321
Query: 350 GGSTE 354
+++
Sbjct: 322 ASASK 326
>At2g45630 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 327
Score = 85.1 bits (209), Expect = 2e-16
Identities = 70/293 (23%), Positives = 125/293 (41%), Gaps = 46/293 (15%)
Query: 87 KSSLPEAELIEKIKD-VHAIGIRSKTKLTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKH 145
+S LP E + D + AI +T ++++ NL ++ G + VDL +
Sbjct: 42 ESPLPLPEFLAYHSDSISAIIAPVAAPVTADLIRILPNLRLVVTTSAGVDHVDLVECRRR 101
Query: 146 GIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAACWEVRG------ 199
GI+V N+ S S VA+ + +I + R++ + V W ++G
Sbjct: 102 GISVANAGSSFSEDVADTAVGLLIDVFRRISAAN--------RFVKQRFWPLKGDYPLGS 153
Query: 200 ----KTLGIIGYGHIGSQLSVLAEALGMNVLY-------YDIVTIMSLGTAKQVSTLNEL 248
K +GI+G G IGS+++ +A G + Y YD+ + E+
Sbjct: 154 KLGRKRIGIVGLGSIGSKVATRLDAFGCQISYSSRNRKPYDV-------PYHYYMDIEEM 206
Query: 249 LNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAG 308
NSD + +T L++ +A+ ++N +RG ++D +++ +R G+I G
Sbjct: 207 AANSDALIICCELNEKTLRLINKDVLSALGKRGVIVNVARGAIIDEEEMVRCLREGEIGG 266
Query: 309 AALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSIG 361
A LDV+ +EP +L L NV+ +PH T E +G
Sbjct: 267 AGLDVFEDEP-------------NVPKELFELDNVVFSPHSAFMTLEGLEELG 306
>7298717 [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 248
Score = 78.6 bits (192), Expect = 2e-14
Identities = 59/237 (24%), Positives = 108/237 (44%), Gaps = 23/237 (9%)
Query: 133 GTNQVDLDFAAKHGIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNKVSA 192
G + VD+ + I + ++P + +VA+L + +I +R+ + + W
Sbjct: 4 GIDYVDVPEVKRRKIPLGHTPTVLNTAVADLAVGLLIAASRRFHEGRKTIDNDKWENYHL 63
Query: 193 ACW----EVRGKTLGIIGYGHIGSQLSVLAEALGMNVLYYDI-----VTIMSLGTAKQVS 243
W ++R T+G G+G IG ++ ++ + Y I AK+V
Sbjct: 64 N-WLLGQDIRDSTVGFYGFGGIGQAIAKRLSGFDIDKVLYTTRRRVHKEIEEEFNAKKVD 122
Query: 244 TLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRA 303
+ LL SDFV P T +T+ + + F MK + ++N +RG +V+ L +A++A
Sbjct: 123 -FDTLLAESDFVVIASPLTKDTQGVFNATAFNKMKQTAVLVNIARGKIVNQDDLYEALKA 181
Query: 304 GKIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEEAQSSI 360
+I A LDV EP L++L NV++ PHIG +T+ ++ +
Sbjct: 182 NRIFSAGLDVTDPEPLSP------------KDKLLTLDNVVVLPHIGSATKRTRADM 226
>At1g01510 [K] KOG0067 Transcription factor CtBP
Length = 634
Score = 73.6 bits (179), Expect = 6e-13
Identities = 73/299 (24%), Positives = 125/299 (41%), Gaps = 44/299 (14%)
Query: 98 KIKDVHAIGIRSKTKLTPEILKHAKNLVVIGCFCIGTNQVDLDFAAKHGIAVFNSPFSNS 157
KI+ A+ + S L + + +I C VD AA G+ + + S +
Sbjct: 57 KIESATAVLLHSLAYLPRAAQRRLRPHQLILCLGSADRAVDSTLAADLGLRLVHVDTSRA 116
Query: 158 RSVAELVIAEIITLARQLGDRSIELHTGTWNKVSAACW------------EVRGKTLGII 205
+A+ V+A I+ L R+ H + + +SA+ W RG LGI+
Sbjct: 117 EEIADTVMALILGLLRRT-------HLLSRHALSASGWLGSLQPLCRGMRRCRGMVLGIV 169
Query: 206 GYGHIGSQLSVLAEALGMNVLYYDIVT--------IMSLGTAKQVSTLNELLNNSDFVTC 257
G L+ + A M+VLY+D+ A+++ TLN+LL SD ++
Sbjct: 170 GRSVSARYLASRSLAFKMSVLYFDVPEGDEERIRPSRFPRAARRMDTLNDLLAASDVISL 229
Query: 258 HVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVYPNE 317
H T +T +L+ +K G++++N ++D A+ Q + G IAG ALD
Sbjct: 230 HCALTNDTVQILNAECLQHIKPGAFLVNTGSCQLLDDCAVKQLLIDGTIAGCALD----- 284
Query: 318 PAKNGAGAFSDN-LNTWTTDLVSLPNVILTPHIGGSTEEAQSSIGIEVATALTKYINEG 375
GA + W +PNV++ P +EE I + + L + +G
Sbjct: 285 ------GAEGPQWMEAW-----EMPNVLILPRSADYSEEVWMEIREKAISILHSFFLDG 332
>Hs20557095 [K] KOG0067 Transcription factor CtBP
Length = 356
Score = 68.9 bits (167), Expect = 2e-11
Identities = 56/204 (27%), Positives = 93/204 (45%), Gaps = 13/204 (6%)
Query: 146 GIAVFNSPFSNSRSVAELVIAEIITLARQLGDRSIELHTGTWNK-----VSAACWEVRGK 200
GI V N P A+ + +I+ L R+ L GTW + + A VR
Sbjct: 72 GIVVCNIPSGALEETADSTVCDILNLYRRNTWVCQALREGTWVQSMEQILEVALGVVRIH 131
Query: 201 TLGIIGYGHIGSQLSVLAEALGMNVLYYDIVTI----MSLGTAKQVSTLNELLNNSDFVT 256
+G++ +G ++ A+A G +V++YD SLG + V TL +LL S V+
Sbjct: 132 AVGLMSFGRTRQAVAFQAKAFGFSVIFYDPYLQDGIERSLGI-QWVYTLQDLLYQSYCVS 190
Query: 257 CHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALDVYPN 316
H +L++ M+ G++++NA+ G +V AL QA++ G+I D +
Sbjct: 191 SHCSLNEHNHHLINDFTIKQMRQGAFLLNAAPGGLVGEKALAQALKEGRI---TRDSFAQ 247
Query: 317 EPAKNGAGAFSDNLNTWTTDLVSL 340
P K+ TW ++ VSL
Sbjct: 248 GPLKDAPNLICIPHTTWYSEQVSL 271
>YPL113c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 396
Score = 68.6 bits (166), Expect = 2e-11
Identities = 45/151 (29%), Positives = 76/151 (49%), Gaps = 13/151 (8%)
Query: 200 KTLGIIGYGHIGSQL-SVLAEALGMNVLYYDIVTIMSLG----TAKQVSTLNE--LLNNS 252
K + I+G+G IG + S L + M++ YY + AK S L++ N+
Sbjct: 218 KKVLILGFGSIGQNIGSNLHKVFNMSIEYYKRTGPVQKSLLDYNAKYHSDLDDPNTWKNA 277
Query: 253 DFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAALD 312
D + +P+T T N+++ A KDG ++N RGT +D L+ A+ +GK+A LD
Sbjct: 278 DLIILALPSTASTNNIINRKSLAWCKDGVRIVNVGRGTCIDEDVLLDALESGKVASCGLD 337
Query: 313 VYPNEPAKNGAGAFSDNLNTWTTDLVSLPNV 343
V+ NE + + L W D+ +LP++
Sbjct: 338 VFKNEETR----VKQELLRRW--DVTALPHI 362
>YPL275w [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 236
Score = 64.7 bits (156), Expect = 3e-10
Identities = 52/200 (26%), Positives = 90/200 (45%), Gaps = 30/200 (15%)
Query: 195 WEVRGKTLGIIGYGHIGSQLSVLAEALGMN---VLYYDIV-----TIMSLGTA------- 239
+++ K + +G G IG + VL + N +LYYD I L A
Sbjct: 22 YDLEDKIISTVGAGRIGYR--VLERLVAFNPKKLLYYDYQELPAEAINRLNEASKLFNGR 79
Query: 240 ----KQVSTLNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIP 295
++V L +++ SD VT + P +++ L + + MKDG+Y++N +RG +
Sbjct: 80 GDIVQRVEKLEDMVAQSDVVTINCPLHKDSRGLFNKKLISHMKDGAYLVNTARGAICVAE 139
Query: 296 ALIQAMRAGKIAGAALDVYPNEPAKNGAGAFSDNLNTW-TTDLVSLPNVILTPHIGGSTE 354
+ +A+++GK+AG DV+ +PA + W T D +T HI G++
Sbjct: 140 DVAEAVKSGKLAGYGGDVWDKQPAPKD--------HPWRTMDNKDHVGNAMTVHISGTSL 191
Query: 355 EAQSSIGIEVATALTKYINE 374
AQ V L Y ++
Sbjct: 192 HAQKRYAQGVKNILNSYFSK 211
>YGL185c [C] KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific
2-hydroxy acid dehydrogenase superfamily)
Length = 379
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/165 (27%), Positives = 77/165 (46%), Gaps = 19/165 (11%)
Query: 198 RGKTLGIIGYGHIGSQLSV-LAEALGMNVLYYDIVT--IMSLGTAKQVSTLNELLNNSDF 254
RGK I+G G IG Q++ L LGM + Y MS + + L+E + +
Sbjct: 196 RGKKCLILGLGSIGKQVAYKLQYGLGMEIHYCKRSEDCTMSQNESWKFHLLDETIYAKLY 255
Query: 255 ----VTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAGKIAGAA 310
+ +P TP+T++L++ G ++N RG ++D+ A+ A+ G+I
Sbjct: 256 QFHAIVVTLPGTPQTEHLINRKFLEHCNPGLILVNLGRGKILDLRAVSDALVTGRINHLG 315
Query: 311 LDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPHIGGSTEE 355
LDV+ EP + SD L + +TPH+G +T++
Sbjct: 316 LDVFNKEPEIDEKIRSSDRLTS------------ITPHLGSATKD 348
>Hs20545061 [K] KOG0067 Transcription factor CtBP
Length = 200
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/104 (31%), Positives = 52/104 (49%), Gaps = 11/104 (10%)
Query: 245 LNELLNNSDFVTCHVPATPETKNLLSGPQFAAMKDGSYVINASRGTVVDIPALIQAMRAG 304
L LL SD V+ H +L++ M+ G++++NA+ G +VD AL Q ++
Sbjct: 106 LEGLLYQSDCVSLHCNLNEHNHHLVNDFTIKQMRQGAFLVNAAHGGLVDEKALAQVLKED 165
Query: 305 KIAGAALDVYPNEPAKNGAGAFSDNLNTWTTDLVSLPNVILTPH 348
+I GAAL ++ +EP + T L PN+I TPH
Sbjct: 166 RIGGAALGLHESEP-----------FSFAQTPLKDAPNLIFTPH 198
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.132 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,029,484
Number of Sequences: 60738
Number of extensions: 1064194
Number of successful extensions: 3068
Number of sequences better than 1.0e-05: 37
Number of HSP's better than 0.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2958
Number of HSP's gapped (non-prelim): 41
length of query: 470
length of database: 30,389,216
effective HSP length: 110
effective length of query: 360
effective length of database: 23,708,036
effective search space: 8534892960
effective search space used: 8534892960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)