ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2632 good A KOG2669 RNA processing and modification Regulator of nuclear mRNA
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2632 924736 925821 362
(362 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR289c [A] KOG2669 Regulator of nuclear mRNA 188 1e-47
SPBC337.03 [A] KOG2669 Regulator of nuclear mRNA 111 2e-24
At5g65180 [A] KOG2669 Regulator of nuclear mRNA 80 5e-15
HsM8922575 [A] KOG2669 Regulator of nuclear mRNA 74 3e-13
Hs21361709 [A] KOG2669 Regulator of nuclear mRNA 74 4e-13
Hs11034845 [A] KOG2669 Regulator of nuclear mRNA 71 3e-12
7298456 [A] KOG2669 Regulator of nuclear mRNA 64 5e-10
Hs18545925 [A] KOG2669 Regulator of nuclear mRNA 59 8e-09
At5g10060 [A] KOG2669 Regulator of nuclear mRNA 58 2e-08
At3g26990 [A] KOG2669 Regulator of nuclear mRNA 55 2e-07
7292210 [A] KOG2669 Regulator of nuclear mRNA 54 4e-07
>YDR289c [A] KOG2669 Regulator of nuclear mRNA
Length = 409
Score = 188 bits (477), Expect = 1e-47
Identities = 98/274 (35%), Positives = 173/274 (62%), Gaps = 11/274 (4%)
Query: 1 MTFSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLV 60
M FS EQF +K+ +L+++Q+SI + SKW+L Y+DA KVA W EY+ + S++T+RKLL
Sbjct: 1 MPFSSEQFTTKLNTLEDSQESISSASKWLLLQYRDAPKVAEMWKEYMLRPSVNTRRKLLG 60
Query: 61 VYLANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVLS 120
+YL N +VQQAK +++ F SFG V L ++ +FP +L+ K+ RVV I ++R + S
Sbjct: 61 LYLMNHVVQQAKGQKIIQFQDSFGKVAAEVLGRINQEFPRDLKKKLSRVVNILKERNIFS 120
Query: 121 ESVLDEIDRRLDVAGKITPSSSTTAQRSKDKVDKRWGQLSSLYDNIEQNQKSGNTLRLRF 180
+ V+++I+R L + +P + + K + +L ++ N+ +++RF
Sbjct: 121 KQVVNDIERSLKT--ESSPVEALVLPQKLKDFAKDYEKLVKMHHNV-------CAMKMRF 171
Query: 181 DKSLEALDPNSVVYAENYNVISKIGSSVKESLTKSIDFRSTLIKELEKLITEQNALVNKE 240
DKS + LDP+S VY EN+ ISKIG+ K+ + +SI R + I +L+ + ++ +++E
Sbjct: 172 DKSSDELDPSSSVYEENFKTISKIGNMAKDIINESILKRESGIHKLQSTLDDEKRHLDEE 231
Query: 241 QDSINEIDSILVDKDPTTIAQSTNSNDADLLPTY 274
Q+ ++EI+ +L KDP+ + + N ++ +++PTY
Sbjct: 232 QNMLSEIEFVLSAKDPSRL--NKNVDEDNIIPTY 263
>SPBC337.03 [A] KOG2669 Regulator of nuclear mRNA
Length = 387
Score = 111 bits (277), Expect = 2e-24
Identities = 73/269 (27%), Positives = 137/269 (50%), Gaps = 14/269 (5%)
Query: 1 MTFSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLV 60
M + + SK+ +L+ETQ+SI + W++ + AD++ W E L++SS + +KLL+
Sbjct: 1 MALTPDTVSSKLATLNETQESITGIAHWVMFHKRYADEIVQIWLEALYESS--SNKKLLL 58
Query: 61 VYLANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVLS 120
+YL N++VQQ++ +++ + + + +++ YA P ++ K+K V +W QR + S
Sbjct: 59 LYLLNEVVQQSRVKKISEYIDAVSPYVVNSVADAYASVPASIKTKIKYVFDVWCQRGIFS 118
Query: 121 ESVLDEIDRRLDVAGKITPSSSTTAQRSKDKVDKRWGQLSSLYDNIEQNQKSGNTLRLRF 180
+ +L + R + A S+ W + L KS ++ +
Sbjct: 119 KEILLSLQERFNNAENSGHSNYYPVG------PPEWAPYTRLMTQTSLYAKSAHSTKTVV 172
Query: 181 DKSLEALDPNSVVYAE---NY-NVISKIGSSVKESLTKSIDFRSTLIKELEKLITEQNAL 236
D ++ Y+E NY ++K S K + I+ RSTLI LE LI EQ L
Sbjct: 173 DALYKSYLEKQSDYSELLDNYKKQLNKASESCKGNYQACIESRSTLITSLESLIEEQKKL 232
Query: 237 VNKEQDSINEIDSIL--VDKDPTTIAQST 263
+++E++S+ ++SI+ ++ +T A ST
Sbjct: 233 LSEEEESLKSVESIISNLENKESTTATST 261
>At5g65180 [A] KOG2669 Regulator of nuclear mRNA
Length = 439
Score = 80.1 bits (196), Expect = 5e-15
Identities = 76/270 (28%), Positives = 118/270 (43%), Gaps = 31/270 (11%)
Query: 3 FSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLVVY 62
FS E + + L+ TQ SI S+W + +A+ V T W + H + I K LL Y
Sbjct: 5 FSEEILIDNLAKLNSTQQSIQTLSQWCIVHRSEAELVVTTWEKQFHSTQIGQKVPLL--Y 62
Query: 63 LANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVL--- 119
LANDI+Q +K RQ F + F VLP AL+ + + + V R+V IW +R+V
Sbjct: 63 LANDILQNSK-RQGNEFVQEFWKVLPGALKDIVSLGDDYGKGVVSRLVNIWEERRVFGSR 121
Query: 120 SESVLD-----EIDRRLDVAGKITPSSSTTAQRSK------------DKVDKRWGQLSSL 162
S+S+ D E LDV+ K S + + SK +K+ + + +
Sbjct: 122 SKSLKDVMLSEEAPPPLDVSKKRFRGSKSAKRDSKSTKTKLSSGGVSEKIVSAFNLVRAE 181
Query: 163 YDN--IEQNQKSGNTLRLR-FDKSLE-----ALDPNSVVYAENYNVISKIGSSVKESLTK 214
N E N+ R+R +K +E A DP A+ I E L
Sbjct: 182 NSNEETEMNKCKSAVRRIRKMEKDVEDACSTAKDPRKESLAKELEEEENILRQSVEKLKS 241
Query: 215 SIDFRSTLIKELEKLITEQNALVNKEQDSI 244
+ R++L+ L + + EQ + + Q I
Sbjct: 242 VEESRTSLVNHLREALREQESELENLQSQI 271
>HsM8922575 [A] KOG2669 Regulator of nuclear mRNA
Length = 312
Score = 73.9 bits (180), Expect = 3e-13
Identities = 67/258 (25%), Positives = 114/258 (43%), Gaps = 22/258 (8%)
Query: 3 FSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLVVY 62
FS K+ L +Q S+ S W++ K + + T W L K+ RKL +Y
Sbjct: 4 FSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAK--PNRKLTFLY 61
Query: 63 LANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVLSES 122
LAND++Q +K R+ P F K F V+ A + V ++ + + RV+ IW +R V
Sbjct: 62 LANDVIQNSK-RKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYEND 120
Query: 123 VLDEIDRRLDVAGKITPSSSTTAQRSKDKVDKRWGQLSSLYDNIEQNQKSGNTLRLRFDK 182
VL+++ + L G P T Q D+ + SSL E Q L +
Sbjct: 121 VLEQLKQAL--YGDKKPRKRTYEQIKVDENE----NCSSLGSPSEPPQ------TLDLVR 168
Query: 183 SLEALDPNSVVYAENYNVISKIGSSVKE-SLTKSIDFR------STLIKELEKLITEQNA 235
+L+ L+ + A + I+ + V+E SL I + S ++++ L+ + N
Sbjct: 169 ALQDLENAASGDAAVHQRIASLPVDVQEVSLLDKITDKESGERLSKMVEDACMLLADYNG 228
Query: 236 LVNKEQDSINEIDSILVD 253
+ E D ++ +L D
Sbjct: 229 RLAAEVDDRKQLTRMLAD 246
>Hs21361709 [A] KOG2669 Regulator of nuclear mRNA
Length = 312
Score = 73.6 bits (179), Expect = 4e-13
Identities = 67/258 (25%), Positives = 114/258 (43%), Gaps = 22/258 (8%)
Query: 3 FSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLVVY 62
FS K+ L +Q S+ S W++ K + + T W L K+ RKL +Y
Sbjct: 4 FSEAALEKKLSELSNSQQSVQTLSLWLIHHRKHSRPIVTVWERELRKAK--PNRKLTFLY 61
Query: 63 LANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVLSES 122
LAND++Q +K R+ P F K F V+ A + V ++ + + RV+ IW +R V
Sbjct: 62 LANDVIQNSK-RKGPEFTKDFAPVIVEAFKHVSSETDESCKKHLGRVLSIWEERSVYEND 120
Query: 123 VLDEIDRRLDVAGKITPSSSTTAQRSKDKVDKRWGQLSSLYDNIEQNQKSGNTLRLRFDK 182
VL+++ + L G P T Q D+ + SSL E Q L +
Sbjct: 121 VLEQLKQAL--YGDKKPRKRTYEQIKVDENE----NCSSLGSPSEPPQ------TLDLVR 168
Query: 183 SLEALDPNSVVYAENYNVISKIGSSVKE-SLTKSIDFR------STLIKELEKLITEQNA 235
+L+ L+ + A + I+ + V+E SL I + S ++++ L+ + N
Sbjct: 169 ALQDLENAASGDAAVHQRIASLPVEVQEVSLLDKITDKESGERLSKMVEDACMLLADYNG 228
Query: 236 LVNKEQDSINEIDSILVD 253
+ E D ++ +L D
Sbjct: 229 RLAAEIDDRKQLTRMLAD 246
>Hs11034845 [A] KOG2669 Regulator of nuclear mRNA
Length = 326
Score = 70.9 bits (172), Expect = 3e-12
Identities = 63/265 (23%), Positives = 119/265 (44%), Gaps = 20/265 (7%)
Query: 2 TFSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLVV 61
+FS K+ L +Q S+ S W++ K A + + W L K+ + RKL +
Sbjct: 3 SFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVSVWHRELRKAK--SNRKLTFL 60
Query: 62 YLANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVLSE 121
YLAND++Q +K R+ P F + F +VL A V + + ++R++ IW++R V
Sbjct: 61 YLANDVIQNSK-RKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYG- 118
Query: 122 SVLDEIDRRLDVAGKITPSSSTTAQRSKDKVDKRWGQLSSLYDN------IEQNQKSGNT 175
E ++L ++ + + S A K + + + Q+ D+ Q+ +G
Sbjct: 119 ---GEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPL 175
Query: 176 LRLRFDKSLEALDPNSVVYAENYNVISKIGSSVKE-SLTKSIDFR------STLIKELEK 228
L K+L+ L+ + A I+ + V++ SL + I + S + E
Sbjct: 176 LTEELIKALQDLENAASGDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACL 235
Query: 229 LITEQNALVNKEQDSINEIDSILVD 253
L+ E N + E + ++ +LV+
Sbjct: 236 LLAEYNGRLAAELEDRRQLARMLVE 260
>7298456 [A] KOG2669 Regulator of nuclear mRNA
Length = 818
Score = 63.5 bits (153), Expect = 5e-10
Identities = 35/133 (26%), Positives = 68/133 (50%), Gaps = 6/133 (4%)
Query: 2 TFSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLVV 61
TF E F +++++L +TQ+ I S W L + K+ W + + +L++
Sbjct: 4 TFDEELFETRLEALKDTQEGIQQMSNWCLQHRSNHKKIIQCWLNVFKR--VRVDHRLVLF 61
Query: 62 YLANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVLSE 121
YLAND++Q +K ++ F + + L A V + ++ K+ R+ IW QR++ +E
Sbjct: 62 YLANDVIQYSKRKRY-EFVECWATALQRATTMVRDE---RVKDKILRIFKIWEQREIYNE 117
Query: 122 SVLDEIDRRLDVA 134
L ++ L++A
Sbjct: 118 EYLSDLSGLLNIA 130
>Hs18545925 [A] KOG2669 Regulator of nuclear mRNA
Length = 152
Score = 59.3 bits (142), Expect = 8e-09
Identities = 35/114 (30%), Positives = 55/114 (47%), Gaps = 5/114 (4%)
Query: 11 KVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLVVYLANDIVQQ 70
K QS+ T +SI S W + K + W ++L +S+ +L + YLAND++Q
Sbjct: 30 KFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSAYP--HRLNLFYLANDVIQN 87
Query: 71 AKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKVLSESVL 124
K + F +SF +VLP A V + V+R+ IW R V E ++
Sbjct: 88 CKRKNAIIFRESFADVLPEAAALVK---DPSVSKSVERIFKIWEDRNVYPEEMI 138
>At5g10060 [A] KOG2669 Regulator of nuclear mRNA
Length = 414
Score = 58.2 bits (139), Expect = 2e-08
Identities = 67/252 (26%), Positives = 118/252 (46%), Gaps = 53/252 (21%)
Query: 56 RKLLVVYLANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQ 115
+K+ ++YLANDI+Q +K RQ F + F NVLP AL+ + + ++ V RV+ IW +
Sbjct: 3 QKVPLLYLANDILQNSK-RQGNEFVQEFWNVLPKALKDIVSQGDDNGKSAVARVIKIWEE 61
Query: 116 RKVL---SESVLD-----EIDRRLDVAGKITPSSSTTAQRSKDKVDKRWG------QLSS 161
R+V S+S+ D ++ LD++ K S ++ + SK K +++S
Sbjct: 62 RRVFGSRSKSLKDVMLGEDVPLPLDISKKRPRGSKSSKRESKSSRTKLASSGGVAEKIAS 121
Query: 162 LY---------DNIEQNQKSGNTLRLR-FDKSLEALDPNSVVYAENYNVISKIGSSVKES 211
Y + E N+ R+R +K +E + ++S
Sbjct: 122 AYHLVVAENSNEEAEMNKCKSAVKRIRKMEKDVEE--------------ACSTDNPKRKS 167
Query: 212 LTKSIDFRSTLIKE-LEKLITEQ---NALVNKEQDSINEIDS--------ILVDKDPTTI 259
L K ++ L+++ +EKL + Q ++LVN+ +D++ E +S I V K+ T
Sbjct: 168 LAKELEEEEYLLRQCIEKLKSVQGSRSSLVNQLKDALREQESELDNLKAQIQVAKEQTEE 227
Query: 260 AQSTNS--NDAD 269
AQ+ ND D
Sbjct: 228 AQNMQKRLNDED 239
>At3g26990 [A] KOG2669 Regulator of nuclear mRNA
Length = 517
Score = 55.1 bits (131), Expect = 2e-07
Identities = 51/181 (28%), Positives = 82/181 (45%), Gaps = 26/181 (14%)
Query: 2 TFSREQFVSKVQSLDETQDSI----VNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRK 57
+F+ + V K+ L+ +Q SI + S W + A V W H + +++
Sbjct: 4 SFNAQILVEKLAKLNNSQASIESILFSLSHWCIFHMNKAKHVVETWGRQFHCAP--REQR 61
Query: 58 LLVVYLANDIVQQAKHRQVPNFDKSFGNVLPSALEKVYADFPTELRAKVKRVVGIWRQRK 117
L +YLANDI+Q ++ R+ F F VLP AL + + R +R+V IW +RK
Sbjct: 62 LAYLYLANDILQNSR-RKGSEFVGEFWKVLPDALRDMIENGDDFGRKSARRLVNIWEERK 120
Query: 118 VLSE--SVLDEIDRRLDVAGKITPSSSTTAQRSKDKVDKRWGQLSSLYDNIEQNQKSGNT 175
V +L E ++ G+ P + T R G L L ++ Q Q +G+T
Sbjct: 121 VFGSRGQILKE-----ELLGR-QPENGT-----------RNGNLVPLKLSVPQRQVNGST 163
Query: 176 L 176
L
Sbjct: 164 L 164
>7292210 [A] KOG2669 Regulator of nuclear mRNA
Length = 375
Score = 53.9 bits (128), Expect = 4e-07
Identities = 39/147 (26%), Positives = 70/147 (47%), Gaps = 13/147 (8%)
Query: 3 FSREQFVSKVQSLDETQDSIVNTSKWMLTLYKDADKVATAWTEYLHKSSISTKRKLLVVY 62
F+ + K+ L+ +Q SI S W++ K + + W L ++ +KL +Y
Sbjct: 4 FTDSALLKKLAELNSSQQSIQTLSLWLIHHRKHSAAIVRTWQRELE--NVPEPKKLTFMY 61
Query: 63 LANDIVQQAKHRQVPNFDKSF----GNVLPSALEKVYADFPTELRAKVKRVVGIWRQRKV 118
LAND++Q +K ++ P + K + G V EK +D +L + R++ IW +R V
Sbjct: 62 LANDVIQNSK-KKGPEYGKEYSLVLGKVFAHIGEKCNSD---KLLGSLGRILNIWLERGV 117
Query: 119 LSESVLDEIDRRLDVAGKITPSSSTTA 145
+ + RL K P SS+++
Sbjct: 118 YDPKTIADWRSRLH---KEAPGSSSSS 141
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.310 0.126 0.334
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,191,592
Number of Sequences: 60738
Number of extensions: 649945
Number of successful extensions: 2092
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2074
Number of HSP's gapped (non-prelim): 12
length of query: 362
length of database: 30,389,216
effective HSP length: 108
effective length of query: 254
effective length of database: 23,829,512
effective search space: 6052696048
effective search space used: 6052696048
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)