ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2675 good U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2675 943312 944511 400
(400 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJL036w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 372 e-103
SPAC6F6.12 [U] KOG2273 Membrane coat complex Retromer subunit VP... 134 2e-31
Hs4507145 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 85 2e-16
At5g06140 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 83 6e-16
Hs7706715 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 69 2e-11
Hs22045020 [U] KOG2273 Membrane coat complex Retromer subunit VP... 65 1e-10
SPBC1711.11 [U] KOG2273 Membrane coat complex Retromer subunit V... 65 2e-10
SPCPJ732.01 [U] KOG2273 Membrane coat complex Retromer subunit V... 64 3e-10
Hs4507141 [U] KOG2273 Membrane coat complex Retromer subunit VPS... 56 8e-08
Hs14725602 [U] KOG2273 Membrane coat complex Retromer subunit VP... 56 1e-07
CE07927 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/... 54 4e-07
>YJL036w [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 423
Score = 372 bits (955), Expect = e-103
Identities = 193/404 (47%), Positives = 269/404 (65%), Gaps = 15/404 (3%)
Query: 9 NKESDTKILSVLVSDPQKQKTH---SQTYITYQVSTKI------DGKDEPNCVV---RRY 56
N E ++VSDPQK+ S Y++YQ+STK D + +P ++ RRY
Sbjct: 20 NPEKPPYWFEIIVSDPQKRTGDPGSSSGYVSYQISTKTNNTSFYDNRGDPESIIVVHRRY 79
Query: 57 NDFVLLHQILINDHXXXXXXXXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSE 116
+D +LLH IL+N Y++GDRFS FTQKRC SLQ F+RR+ H +
Sbjct: 80 SDLLLLHDILLNRFPTCIIPPLPDKKVFQYIAGDRFSQRFTQKRCHSLQNFLRRVSLHPD 139
Query: 117 LSKSRILETFLTSTDWDVYRRSLTGQISTS--EVSDVLINAFKHVNRQRDEFVEIKEKSE 174
LS+S++ +TFL S DW+ +R+ L + + EV+D +NAFK V++Q +EF EI+EKS+
Sbjct: 140 LSQSKVFKTFLVSKDWESHRKVLQDSLQPNKDEVTDAFMNAFKTVHKQNEEFTEIREKSD 199
Query: 175 KLDHNLSHLDKLFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDE-KELSNSIKAFNDGTM 233
KLD ++ +DKLFHK VK+ D + E +EL+ +K FN+G
Sbjct: 200 KLDRTVTKIDKLFHKVVKKNDSMSEDYTKLGSNLQELQELVTGENEELAAKLKIFNEGVT 259
Query: 234 QLIDSLNDLNKYVDYEYNVDIKDMINYIEALKQLIRLKDQKQIDYEELSEYLTRSINEKN 293
QL L DL KY+DYEY VD+KD+ +YI++++QLI+LKDQKQIDYEELS+YLTRSI EKN
Sbjct: 260 QLSYGLQDLTKYLDYEYIVDLKDLEHYIDSMRQLIKLKDQKQIDYEELSDYLTRSIKEKN 319
Query: 294 NLLSGYGSGNYFKSKLEELAGINQEMARRDKIAKLETRVQSLTDEVEKSKQVADEFEKEV 353
NL+SGYG N+F +KLEELAGINQE +RR+KI KLE ++ SLT E+E +K+VAD FE+E
Sbjct: 320 NLISGYGGSNFFANKLEELAGINQEASRREKINKLEGKITSLTGELENAKKVADGFEQEC 379
Query: 354 LKEVEQFEQIKTLELKDSLAALAQKHIDFYDDMVEKWSKIEERL 397
LKE++ FE +KT E+K SL +LA HI+FY+ ++E W K+++ L
Sbjct: 380 LKEIDHFESVKTAEIKKSLGSLADHHIEFYERILEAWEKVDDSL 423
>SPAC6F6.12 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 401
Score = 134 bits (338), Expect = 2e-31
Identities = 96/405 (23%), Positives = 193/405 (46%), Gaps = 14/405 (3%)
Query: 1 MSESGTLTNKESD-TKILSVLVSDPQKQKTHSQ-TYITYQVSTKIDGK--DEPNCVVRR- 55
MS+S L ++ T L LV++P+K+ S+ T+++Y + TK + C VRR
Sbjct: 1 MSDSVNLDEPSTNSTHFLQCLVTEPRKELQGSRDTHVSYLIITKTNLSIFTRAECKVRRR 60
Query: 56 YNDFVLLHQILINDHXXXXXXXXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHS 115
++DFV L +IL + Y+ G RFS +F +R + L ++ R H
Sbjct: 61 FSDFVKLQEILSRMNEDCVVPPLPAKHKLEYIKGGRFSDNFINRRAKLLNRYITRCALHP 120
Query: 116 ELSKSRILETFLTSTDWDVYRR-----SLTGQISTSEVSDVLINAFKHVNRQRDEFVEIK 170
L +S FL + +W+ Y R L E+SD L+NAF + + EF +
Sbjct: 121 VLHQSPHFIAFLENPNWNNYVRFFIQPKLNNTSKLDEISDSLLNAFSKLKEEPTEFDIQR 180
Query: 171 EKSEKLDHNLSHLDKLFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNSIKAFND 230
+ ++ +S+L+ K ++ + ++ L I++ +
Sbjct: 181 DHVQQFMFGISNLEGSIQKLLRLEKALESDYEDVSIQFDRLASL---DQALDVPIESIQN 237
Query: 231 GTMQLIDSLNDLNKYVDYEYNVDIKDMINYIEALKQLIRLKDQKQIDYEELSEYLTRSIN 290
Q +L + + + IKD+ +Y +LK+L++ +DQKQ D E L EY +
Sbjct: 238 ALQQTGTEYANLTEKLTLLLDT-IKDVESYAHSLKELLKRRDQKQQDVEALQEYSAKLSL 296
Query: 291 EKNNLLSGYGSGNYFKSKLEELAGINQEMARRDKIAKLETRVQSLTDEVEKSKQVADEFE 350
E++ + SG +G L++L GI+ R ++ +++ +Q++ ++++ V D F
Sbjct: 297 ERDKISSGGSNGFSLSKTLDDLRGIDHNDTRLKRLEHVQSELQAVEQAIQEASAVHDAFN 356
Query: 351 KEVLKEVEQFEQIKTLELKDSLAALAQKHIDFYDDMVEKWSKIEE 395
+ V +E + F+ ++ E+ +++ A H++F+ ++ + W ++++
Sbjct: 357 QRVREESKLFDSVRQSEMLSAISDYANVHVEFFTNIRDLWIRVKQ 401
>Hs4507145 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 450
Score = 84.7 bits (208), Expect = 2e-16
Identities = 88/405 (21%), Positives = 166/405 (40%), Gaps = 21/405 (5%)
Query: 6 TLTNKESDTKILSVLVSDPQKQKTHS-----QTYITYQVSTK----IDGKDE-PNCVVRR 55
T+T+ K + + VS+ +K+ + +TY Y + T+ DG+ + + RR
Sbjct: 47 TMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRR 106
Query: 56 YNDFVLLHQILINDHXXXXXX---XXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLL 112
Y++F LL L+ + + LS D F ++R L+ F+ R+
Sbjct: 107 YSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIA 166
Query: 113 SHSELSKSRILETFLTST-DWDVYRRSLTGQISTSEVSDVLINAFKHVNRQRDEFVEIKE 171
SH L + +I FLT +W Q+ L NA V F ++K
Sbjct: 167 SHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKAL-NATFRVKNPDKRFTDLKH 225
Query: 172 KSEKLDHNLSHLDKLFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNSIKAFNDG 231
S++L +SHL ++ + D + EKE+ + +++
Sbjct: 226 YSDELQSVISHLLRV---RARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHH 282
Query: 232 TMQLIDSLNDLNKYVDYEYNVD-IKDMINYIEALKQLIRLKDQKQIDYEELSEYLTRSIN 290
S++D+ + D E+ D +K+ + Y EAL+ + R + Q D E ++ L
Sbjct: 283 MDVYASSIDDILE--DEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQ 340
Query: 291 EKNNLLSGYGSGNYFKSKLEELAGINQEMARRDKIAKLETRVQSLTDEVEKSKQVADEFE 350
+ L++G K +L G R +I LE ++ +++ EF
Sbjct: 341 QCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFV 400
Query: 351 KEVLKEVEQFEQIKTLELKDSLAALAQKHIDFYDDMVEKWSKIEE 395
K ++E+F++ K +LK++L + A I ++ W+ +E
Sbjct: 401 KNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKE 445
>At5g06140 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 402
Score = 83.2 bits (204), Expect = 6e-16
Identities = 90/416 (21%), Positives = 166/416 (39%), Gaps = 46/416 (11%)
Query: 4 SGTLTNKESDTK--ILSVLVSDPQKQKTHSQTYITYQVSTKI---DGKDEPNCVVRRYND 58
SG++ + S + LSV V+DP K Q YI+Y+V TK + + V+RRY+D
Sbjct: 11 SGSMQSPRSPSSHPYLSVSVTDPVKLGNGVQAYISYRVITKTNLPEYQGPEKIVIRRYSD 70
Query: 59 FVLLHQILINDHXXXXXXXXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSELS 118
FV L L + RFS F + R +L F+ R+ H EL
Sbjct: 71 FVWLRDRLFEKYKGIFIPPLPEKSAVEKF---RFSAEFIEMRRAALDIFVNRIALHPELQ 127
Query: 119 KSRILETFLTSTD--WDVYRRSLTGQIST------------SEVSDVLINAFKHVNRQRD 164
+S L TFL + + D +R T S+VSD ++ K V
Sbjct: 128 QSEDLRTFLQADEETMDRFRFQETSIFKKPADLMQMFRDVQSKVSDAVLGKEKPVEETTA 187
Query: 165 EFVEIKEKSEKLDHNLSHLDKLFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNS 224
++ ++K +L+++L+ K ++ VKR + C+ + +
Sbjct: 188 DYEKLKHYIFELENHLTEAQKHAYRLVKRHRELGQSLLDFGKAVKLLGA--CEGEPTGKA 245
Query: 225 IKAFNDGTMQLIDSLNDLNKYVDYEYNVDIKDMINYIEALKQLIRLKDQKQIDYEELSEY 284
+ L L + V + +KD + Y++++K I + + ELSE
Sbjct: 246 FSDLGTKSELLSIKLQKEAQQVLMNFEEPLKDYVRYVQSIKATIAERGTAFKQHCELSE- 304
Query: 285 LTRSINEKNNLLSGYGSGNYFKSKLEELAGINQEMARRDKIAKLETRVQSLTDEVEKSKQ 344
+KL+E+ + R DK+ + E + + E E++ +
Sbjct: 305 ---------------------TTKLKEINLDKLMLTRSDKVGEAEIEYREIKAESEEATR 343
Query: 345 VADEFEKEVLKEVEQFEQIKTLELKDSLAALAQKHIDFYDDMVEKWSKIEERLESA 400
+ K + E+ +F++ KT E+ + A+ + + + W + +LE++
Sbjct: 344 RFERIVKRMEDEIVRFQEQKTEEMGVAFHQFAKGQARLANSVADAWRSLLPKLEAS 399
>Hs7706715 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 387
Score = 68.6 bits (166), Expect = 2e-11
Identities = 83/404 (20%), Positives = 164/404 (40%), Gaps = 86/404 (21%)
Query: 11 ESDTKILSVLVSDPQKQKTHSQTYITYQVSTKIDGKDEPNC---VVRRYNDFVLLHQILI 67
E D K L + V +P+ T +T+ITY++ TK + + V RRY DF+ L L
Sbjct: 26 EPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLE 85
Query: 68 NDHXXXXXXXXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILETFL 127
H + +RF+ F + R ++L F+ R+ H L+ + + FL
Sbjct: 86 EAHPTLIIPPLPEKFIVKGMV-ERFNDDFIETRRKALHKFLNRIADHPTLTFNEDFKIFL 144
Query: 128 TSTDWDV--YRRSLTGQIS-TSEVSDVLINAFKHVNRQRDEFVEIKEKSEKLDHNLSHLD 184
T+ W++ +++ G +S + + ++ + V + +EF+E+ E ++ +D
Sbjct: 145 TAQAWELSSHKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLID 204
Query: 185 KLFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNSIKAF-------NDGTMQLID 237
K+ + K +E+E + +K + + L+D
Sbjct: 205 KISQRIYK------------------------EEREYFDEMKEYGPIHILWSASEEDLVD 240
Query: 238 SLNDLNKYVDYEYNVDIKDMINYIEALKQLIRLKDQKQIDYEELSEYLTRSINEKNNLLS 297
+L D+ +D K M EAL ++ EY+ S
Sbjct: 241 TLKDVASCIDRCCKATEKRMSGLSEALLPVVH-------------EYVLYS--------- 278
Query: 298 GYGSGNYFKSKLEELAGINQEMARRDKI-AKLETRVQSLT----------DEVEKSKQVA 346
E L G+ M RRD+I A+L+++V+ LT +E+ K +
Sbjct: 279 ------------EMLMGV---MKRRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKV 323
Query: 347 DEFEKEVLKEVEQFEQIKTLELKDSLAALAQKHIDFYDDMVEKW 390
+ + + E+++Q ++K + +A+++I +Y+ + W
Sbjct: 324 ECANNALKADWERWKQNMQNDIKLAFTDMAEENIHYYEQCLATW 367
>Hs22045020 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 333
Score = 65.5 bits (158), Expect = 1e-10
Identities = 71/366 (19%), Positives = 145/366 (39%), Gaps = 49/366 (13%)
Query: 32 QTYITYQVSTK---IDGKDEPNCVVRRYNDFVLLHQILINDHXXXXXXXXXXXXXXNYLS 88
+TYITY+++TK ++ V RRY DF L L +
Sbjct: 2 ETYITYRITTKSTRVEFDLPEYSVRRRYQDFDWLRSKLEESQPTHLIPPLPEKFVVKGVV 61
Query: 89 GDRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILETFLTSTDWDVYRRSLTGQISTSEV 148
DRFS F + R ++L F++R+ H LS + FLT+ D + Y++ ++
Sbjct: 62 -DRFSEEFVETRRKALDKFLKRITDHPVLSFNEHFNIFLTAKDLNAYKKQGIALLTRMGE 120
Query: 149 SDVLINAFKHVNRQRDEFVEIKEKSEKLDHNLSHLDKLFHKSVK-RVDLIXXXXXXXXXX 207
S + + + EF I + + L +D++ + +K ++ +
Sbjct: 121 SVKHVTGGYKLRTRPLEFAAIGDYLDTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVY 180
Query: 208 XXXXXXXCCDEKELSNSIKAFNDGTMQLIDSLNDLNKYVDYEYNVDIKDMINYIEALKQL 267
E EL+ ++ + +L +L + ++ +++ I Y +++K +
Sbjct: 181 STWSAL----EGELAEPLEGVSACIGNCSTALEELTDDMTEDFLPVLREYILYSDSMKSV 236
Query: 268 IRLKDQKQIDYEELSEYLTRSINEKNNLLSGYGSGNYFKSKLEELAGINQEMARRDKIAK 327
++ +DQ Q +YE +KLE +A R++ K
Sbjct: 237 LKKRDQVQAEYE---------------------------AKLEAVA------LRKEDRPK 263
Query: 328 LETRVQSLTDEVEKSKQVADEFEKEVLKEVEQFEQIKTLELKDSLAALAQKHIDFYDDMV 387
+ V+ D +E F ++ ++E+++ K + + L +A K+I +Y+ +
Sbjct: 264 VPADVEKCQDRMEC-------FNADLKADMERWQNNKRQDFRQLLMGMADKNIQYYEKCL 316
Query: 388 EKWSKI 393
W I
Sbjct: 317 MAWESI 322
>SPBC1711.11 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 390
Score = 65.1 bits (157), Expect = 2e-10
Identities = 64/269 (23%), Positives = 111/269 (40%), Gaps = 26/269 (9%)
Query: 33 TYITYQVSTKID---GKDEPNCVVRRYNDFVLLHQILINDHXXXXXXXXXXXXXXNYLSG 89
T+++Y++ T+ D +D+ V RRY DF +LH IL +D+ + SG
Sbjct: 19 TFVSYEIETESDLPVFEDKKFSVRRRYKDFEMLHNILSHDYNGYAIPPLPRKYTVSSFSG 78
Query: 90 DRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILETFLTSTDWDVYRRSLTGQISTSE-- 147
S F +R +SLQTF+ R +H +S S + FL + W Y + Q ++
Sbjct: 79 GSLSPIFIARRMQSLQTFLDRCSTHPVISNSMHMYQFLENNSWKSYYHNAWMQSENTKSK 138
Query: 148 ---VSDVLINAFKHVNRQRDEFVE-IKEKSEKLDHNLSHLDKLFHKSVKRVDLIXXXXXX 203
VS + ++ ++++ E K+ + D +LS L+K + + V
Sbjct: 139 GNNVSGGIESSIQNLDPYAQSLYETAKQLLQNADTDLSKLEKTCVQYMNSVQNFPTDIPV 198
Query: 204 XXXXXXXXXXXCCDE-KELS-NSIKAFNDGTMQLIDSLNDLNKYVDYEYNVDIKDMINYI 261
E K L NSI N ++I S+ DL +Y+
Sbjct: 199 PSNLSISNLDVVSVEFKRLKRNSIFLINSFHSKVITSIQDLE---------------DYM 243
Query: 262 EALKQLIRLKDQKQIDYEELSEYLTRSIN 290
K LI+ ++QK +E + + + N
Sbjct: 244 VVFKSLIKSREQKVKQFEHFQQIVQSNSN 272
>SPCPJ732.01 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 576
Score = 64.3 bits (155), Expect = 3e-10
Identities = 86/408 (21%), Positives = 166/408 (40%), Gaps = 76/408 (18%)
Query: 19 VLVSDPQKQKTHSQTYITYQVSTKIDGKDEPNC----VVRRYNDFVLLHQILINDHXXXX 74
+ V DP K ++++ Y VST+++ ++P+ V RRYNDF L+Q+L N+H
Sbjct: 204 IQVHDPHTVKEITKSHTVYSVSTRLEEHNQPSVSNVTVQRRYNDFAFLYQLLSNNHPGCI 263
Query: 75 XXXXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILETFLTSTDWDV 134
RF F ++R +L+ +R++ +H L + FL + +D
Sbjct: 264 IPPIPEKQVVG-----RFDDEFIEQRRAALEVMLRKISAHPVLRDDYSFKLFLEAETFDP 318
Query: 135 YRRSLTGQI-----------STSEVSDVLINAF-----KHVNRQRDEFVEIKEKSEKLDH 178
T I STS + D +AF + Q +E K+ + L+
Sbjct: 319 RMTHRTTLIESSSSPLRSGPSTSGLLDSFTSAFHTSGSSKFSEQDPILIEAKDTLDSLE- 377
Query: 179 NLSHLDKLFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNSIKAFNDGTMQLIDS 238
+ L ++H + +D + +++I F + L S
Sbjct: 378 --TQLKSVYHALLLSID---------------------QRIQFASAIHDFGEAVGNL--S 412
Query: 239 LNDLNKYVDYEYNVDIKDMINYIEALKQLIRLKDQKQIDYEELS------EYLTRSINEK 292
L DL + ++ + + L+ +R ++++ + L+ EY+ + K
Sbjct: 413 LVDLEPTLSSKF--------DGLSQLQVELRFVQERKVAQDNLTLGTTLEEYIRYVESAK 464
Query: 293 NNLLSGYGSGNYFKSKLEELAGINQEMARRDKIAKLETR-VQSLTDEVEKSKQVADEFEK 351
N + ++S ++ ++ ++ + K AK + + + L ++ EK + A + EK
Sbjct: 465 NAFTTRQKLWQTWQSSVQAVSRAKTQLEKCKKQAKSQQKSLPYLEEQYEKYRAKAADLEK 524
Query: 352 EVLKEVEQFEQIKTLELKDSLAALAQKHIDFYDDMVEKWSKIEERLES 399
E F + TL LK L++L +D VE W +E +ES
Sbjct: 525 E-------FSESTTL-LKRDLSSLTTSRVDDLKASVETW--LESAIES 562
>Hs4507141 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 519
Score = 56.2 bits (134), Expect = 8e-08
Identities = 76/388 (19%), Positives = 149/388 (37%), Gaps = 35/388 (9%)
Query: 17 LSVLVSDPQKQKTHSQTYITYQVSTKID----GKDEPNCVVRRYNDFVLLHQILINDHXX 72
+ + VSDP+K Y+ Y+V+TK K E + V RR++DF+ LH L + +
Sbjct: 142 IEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFS-VKRRFSDFLGLHSKLASKYLH 200
Query: 73 XXXX-------XXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILET 125
D S F +KR +L+ +++R + H L + L
Sbjct: 201 VGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQ 260
Query: 126 FLTSTDWDVYRRSLTGQISTSEVSDVLINAFKHVNRQRDEFVEIKEKSEKLDHNLSHLDK 185
FL S++ + R T +S + + ++ A VN+ + E E+ +LD+
Sbjct: 261 FLESSE--LPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQ 318
Query: 186 LFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNSIKAFNDGTMQLIDSLND--LN 243
K V+ + C KELS + AF L +S + L+
Sbjct: 319 QLRKLHVSVEALF-----------------CHRKELSANTAAFAKSAAMLGNSEDHTALS 361
Query: 244 KYVDYEYNVDIK-DMINYIEALKQLIRLKDQKQIDYEELSEYLTRSINEKNNLLSGYGSG 302
+ + V+ K D ++ +A + DY L + + + +
Sbjct: 362 RALSQLAEVEEKIDQLHQEQAFSDFYMFSELLS-DYIRLIAAVKGVFDHRMKCWQKWEDA 420
Query: 303 NYFKSKLEELAGINQEMARRDKIAKLETRVQSLTDEVEKSKQVADEFEKEVLKEVEQFEQ 362
K E + DKI + + ++ +V++ ++ ++ K + KEV +FE+
Sbjct: 421 QITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEK 480
Query: 363 IKTLELKDSLAALAQKHIDFYDDMVEKW 390
+ + K + + + +++ W
Sbjct: 481 ERVKDFKTVIIKYLESLVQTQQQLIKYW 508
>Hs14725602 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 519
Score = 55.8 bits (133), Expect = 1e-07
Identities = 76/388 (19%), Positives = 149/388 (37%), Gaps = 35/388 (9%)
Query: 17 LSVLVSDPQKQKTHSQTYITYQVSTKID----GKDEPNCVVRRYNDFVLLHQILINDHXX 72
+ + VSDP+K Y+ Y+V+TK K E + V RR++DF+ LH L + +
Sbjct: 142 IEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFS-VKRRFSDFLGLHSKLASKYLH 200
Query: 73 XXXX-------XXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILET 125
D S F +KR +L+ +++R + H L + L
Sbjct: 201 VGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQ 260
Query: 126 FLTSTDWDVYRRSLTGQISTSEVSDVLINAFKHVNRQRDEFVEIKEKSEKLDHNLSHLDK 185
FL S++ + R T +S + + ++ A VN+ + E E+ +LD+
Sbjct: 261 FLESSE--LPRAVNTQALSGAGILRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQ 318
Query: 186 LFHKSVKRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNSIKAFNDGTMQLIDSLND--LN 243
K V+ + C KELS + AF L +S + L+
Sbjct: 319 QLRKLHVSVEALV-----------------CHRKELSANTAAFAKSAAMLGNSEDHTALS 361
Query: 244 KYVDYEYNVDIK-DMINYIEALKQLIRLKDQKQIDYEELSEYLTRSINEKNNLLSGYGSG 302
+ + V+ K D ++ +A + DY L + + + +
Sbjct: 362 RALSQLAEVEEKIDQLHQEQAFADFYMFSELLS-DYIRLIAAVKGVFDHRMKCWQKWEDA 420
Query: 303 NYFKSKLEELAGINQEMARRDKIAKLETRVQSLTDEVEKSKQVADEFEKEVLKEVEQFEQ 362
K E + DKI + + ++ +V++ ++ ++ K + KEV +FE+
Sbjct: 421 QITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEK 480
Query: 363 IKTLELKDSLAALAQKHIDFYDDMVEKW 390
+ + K + + + +++ W
Sbjct: 481 ERVKDFKTVIIKYLESLVQTQQQLIKYW 508
>CE07927 [U] KOG2273 Membrane coat complex Retromer subunit VPS5/SNX1
Sorting nexins and related PX domain-containing proteins
Length = 472
Score = 53.9 bits (128), Expect = 4e-07
Identities = 71/396 (17%), Positives = 154/396 (37%), Gaps = 43/396 (10%)
Query: 19 VLVSDPQKQKTHSQTYITYQVSTKIDG----KDEPNCVVRRYNDFVLLHQILINDHXXXX 74
V + + +K+ YI Y++ T++ G + RR++DF+ LH ++ +
Sbjct: 92 VTMREFEKRGDGMNAYIVYKLETEVSGVVGYTKQHYETWRRFSDFLGLHGKIVEKYLAKG 151
Query: 75 XX-------XXXXXXXXNYLSGDRFSHSFTQKRCRSLQTFMRRLLSHSELSKSRILETFL 127
S S +R R L+ ++ RL+ H + + FL
Sbjct: 152 IVIPQPPEKSISALTKTKTNSDPAMSREVGIQRARQLERYICRLIQHPRMRNDCDVRDFL 211
Query: 128 TSTDWDVYRRSLTGQISTSEVSDVLIN--------AFKHVNRQRDEFVEIKEKSEKLDHN 179
T + D+ + T +S+ V + N AF H+ F +++ + ++LD
Sbjct: 212 T-IESDLPKAVQTAALSSFGVKKIFKNFQVVFSKMAF-HMEEGDRWFEQVQSQVDELDEA 269
Query: 180 LSHLDKLFHKSV-KRVDLIXXXXXXXXXXXXXXXXXCCDEKELSNSIKAFNDGTMQLIDS 238
L L + V R D+ C + LS ++ + D T +
Sbjct: 270 LRKLYTVTETLVASRRDM--ATSGEQLGKALSMLAACEESTSLSRALSSLTDVTENVSAV 327
Query: 239 LNDLNKYVDYEYNVDIKDMINYIEALKQLIRLKDQKQIDYEELSEYLTRSINEKNNLLSG 298
+ + +++ I + I I ALK + + + +++ + L R ++
Sbjct: 328 YGKQAEVDNSKFSESIYEYIMLISALKDVFGERVRAWQQWQDAQQTLARKRDQ------- 380
Query: 299 YGSGNYFKSKLEELAGINQEMARRDKIAKLETRVQSLTDEVEKSKQVADEFEKEVLKEVE 358
K+K++ AG R ++ +L+ ++ ++++ +Q E K + +EV
Sbjct: 381 -------KTKIDLSAG-----GRNERSDQLKGEIEDTVQKMDQLEQHFIELSKAIREEVA 428
Query: 359 QFEQIKTLELKDSLAALAQKHIDFYDDMVEKWSKIE 394
+F+ + ++K L + I + +++ W K E
Sbjct: 429 RFDADRKQDMKKMLVEYMESMIHTHTELLHLWEKFE 464
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.131 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,471,040
Number of Sequences: 60738
Number of extensions: 794733
Number of successful extensions: 3676
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 3645
Number of HSP's gapped (non-prelim): 11
length of query: 400
length of database: 30,389,216
effective HSP length: 109
effective length of query: 291
effective length of database: 23,768,774
effective search space: 6916713234
effective search space used: 6916713234
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)