ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2762 good L KOG1978 Replication, recombination and repair DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2762 974391 971623 -923
(923 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL082w [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2... 649 0.0
7303075 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2... 417 e-116
Hs4505913 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pm... 416 e-116
SPAC19G12.02c [L] KOG1978 DNA mismatch repair protein - MLH2/PMS... 264 5e-70
CE19915 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2... 235 2e-61
At4g02460 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pm... 232 2e-60
Hs4505911 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pm... 171 6e-42
Hs4557757 [L] KOG1979 DNA mismatch repair protein - MLH1 family 149 2e-35
At4g09140 [L] KOG1979 DNA mismatch repair protein - MLH1 family 141 5e-33
ECU11g1260 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/P... 140 7e-33
SPBC1703.04 [L] KOG1979 DNA mismatch repair protein - MLH1 family 136 1e-31
Hs4885551 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pm... 132 3e-30
YMR167w [L] KOG1979 DNA mismatch repair protein - MLH1 family 130 9e-30
7304079 [L] KOG1979 DNA mismatch repair protein - MLH1 family 129 2e-29
Hs22046611 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/P... 116 2e-25
CE18978 [L] KOG1979 DNA mismatch repair protein - MLH1 family 100 8e-21
Hs7657337 [L] KOG1977 DNA mismatch repair protein - MLH3 family 95 6e-19
At4g35520 [L] KOG1977 DNA mismatch repair protein - MLH3 family 94 7e-19
Hs22046253 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/P... 93 2e-18
YLR035c [R] KOG0017 FOG: Transposon-encoded proteins with TYA re... 92 3e-18
ECU05g0300 [L] KOG1979 DNA mismatch repair protein - MLH1 family 86 2e-16
YPL164c [L] KOG1977 DNA mismatch repair protein - MLH3 family 83 2e-15
Hs4885553 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pm... 70 1e-11
>YNL082w [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 904
Score = 649 bits (1674), Expect = 0.0
Identities = 386/933 (41%), Positives = 540/933 (57%), Gaps = 75/933 (8%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I I + D+H+ITSGQVI DL +A+KEL++NS+DA A++IEIIFK+YG+ESIEC+DNG G
Sbjct: 35 IHQINDIDVHRITSGQVITDLTTAVKELVDNSIDANANQIEIIFKDYGLESIECSDNGDG 94
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPKAYKI 122
I + + + KH TSKI+ F+DV+KV + GFRGEA++SLC + K+ + TTT PKA K+
Sbjct: 95 IDPSNYEFLALKHYTSKIAKFQDVAKVQTLGFRGEALSSLCGIAKLSVITTTSPPKADKL 154
Query: 123 VFNHSG-TCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAIIQ 181
++ G +K SRN GTTVLVS LF LPVR+K+F K +KRQF + + +IQ YAII
Sbjct: 155 EYDMVGHITSKTTTSRNKGTTVLVSQLFHNLPVRQKEFSKTFKRQFTKCLTVIQGYAIIN 214
Query: 182 TNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHTS 241
+K SV N+ P GKK LILS++ S + +N+ SVFG+ +GL +D+ LDL+ ++
Sbjct: 215 AAIKFSVWNITPKGKKNLILSTMRNSSMRKNISSVFGAGGMRGLEEVDLVLDLNPFKNRM 274
Query: 242 ILPENQKEENAS-EFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINETY 300
+ + ++++++ G IS SFGCGR SKDRQ++Y+NKRPV+Y + K NE Y
Sbjct: 275 LGKYTDDPDFLDLDYKIRVKGYISQNSFGCGRNSKDRQFIYVNKRPVEYSTLLKCCNEVY 334
Query: 301 QSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQLFFQKQGFVV 360
++FNNVQ+P+ L+ + +D+NVTPDKR + LH E V+D + +L ++ +Q +
Sbjct: 335 KTFNNVQFPAVFLNLELPMSLIDVNVTPDKRVILLHNERAVIDIFKTTLSDYYNRQELAL 394
Query: 361 PKSETTSDNPFGPKRIKVEPL-DASTLHNSENSKIISNGNHLRHPTIIKDEVHELPRLIS 419
PK + KR+K E D ST H S+N + H
Sbjct: 395 PKRMCSQSEQQAQKRLKTEVFDDRSTTHESDN-----------------ENYH------- 430
Query: 420 PLRSPTLAKMKGESEQSELKSSTVETEDLDDGFDDKLHNHRESVHKDEISANNHLDYVAE 479
T +S + S+T G DK N E + + N D +
Sbjct: 431 -----TARSESNQSNHAHFNSTT--------GVIDK-SNGTELTSVMDGNYTNVTDVIGS 476
Query: 480 DVNTGPH---LLNPHEKEGDTKRLFVDSDLENTIESESNVISKELDESEDVDIDKNNLKV 536
+ +L+ TK+L +I+++S +S D++ NN
Sbjct: 477 ECEVSVDSSVVLDEGNSSTPTKKL-------PSIKTDSQNLS---------DLNLNNFS- 519
Query: 537 TPKGNHIQLGDFLHRRMSNVDIEKSPVEVDELVVQIDNNISTIPASQDRDNKLVFHPHTS 596
P+ +I D + S + + PV D ID A + + LVF +
Sbjct: 520 NPEFQNITSPD---KARSLEKVVEEPVYFD-----IDGEKFQEKAVLSQADGLVFVDNEC 571
Query: 597 HSGNDSCRHSHNHSPNES---DYSDDDFENGTDIVFKNTVENESDLEQIKKQIEGSSSES 653
H + C H ++ D +D + + ++ + I K S S+
Sbjct: 572 HEHTNDCCHQERRGSTDTEQDDEADSIYAEIEPVEINVRTPLKNSRKSISKDNYRSLSDG 631
Query: 654 LSLHQINNLVTSVRASLKIEAEKS---QKVVCAIEIDKAIKHERLVNEIASIDDKEKAEH 710
L+ + + + S K E S +++ I K+ E ++ ++D E+ E
Sbjct: 632 LTHRKFEDEILEYNLSTKNFKEISKNGKQMSSIISKRKSEAQENIIKNKDELEDFEQGEK 691
Query: 711 LLTLTVSKNDFQNMTIVGQFNLGFIIVTRCKEGAFDLFIVDQHASDEKYNFEMLQKNTVF 770
LTLTVSKNDF+ M +VGQFNLGFIIVTR + +DLFIVDQHASDEKYNFE LQ TVF
Sbjct: 692 YLTLTVSKNDFKKMEVVGQFNLGFIIVTRKVDNKYDLFIVDQHASDEKYNFETLQAVTVF 751
Query: 771 KSQSLLSLKTLELSVIDELLVMEYKDVFSKNGFKLSIDQEEEPGQRIKLVSFPVSKNTMF 830
KSQ L+ + +ELSVIDEL+V++ VF KNGFKL ID+EEE G R+KL+S P SK T+F
Sbjct: 752 KSQKLIIPQPVELSVIDELVVLDNLPVFEKNGFKLKIDEEEEFGSRVKLLSLPTSKQTLF 811
Query: 831 TEYDFHELIQLIREHEGHDMSNIRCSKIRSMFAMRACRSSIMIGKPLSMRTMKKVVNNLS 890
DF+ELI LI+E G NIRCSKIRSMFAMRACRSSIMIGKPL+ +TM +VV+NLS
Sbjct: 812 DLGDFNELIHLIKEDGGLRRDNIRCSKIRSMFAMRACRSSIMIGKPLNKKTMTRVVHNLS 871
Query: 891 DLEKPWNCPHGRPTLRHLMELKDWDSFCDDYMI 923
+L+KPWNCPHGRPT+RHLMEL+DW SF DY I
Sbjct: 872 ELDKPWNCPHGRPTMRHLMELRDWSSFSKDYEI 904
>7303075 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 899
Score = 417 bits (1071), Expect = e-116
Identities = 292/946 (30%), Positives = 472/946 (49%), Gaps = 126/946 (13%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+AI +HKI SGQV++ L A+KEL+ENS+DA A +EI K+ G++S+E +DNG G
Sbjct: 27 IKAIGKDTVHKICSGQVVLSLAVAVKELVENSIDAGATLVEIKLKDQGLQSVEVSDNGSG 86
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPK-AYK 121
+ E +L+ + K+ TSKI F D+ V +FGFRGEA++SLC + ++I T K K
Sbjct: 87 VEEMNLEGMTAKYHTSKIREFVDLLGVETFGFRGEALSSLCALSDMVIQTRHKSTDVGVK 146
Query: 122 IVFNHSGTCNK-IICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAII 180
+ +H G K C+R GTTVL++NLF TLPVR++DF +N K++F + ++Q+Y ++
Sbjct: 147 VELDHEGRIKKRSPCARGVGTTVLLANLFSTLPVRRRDFTRNIKKEFTKMCQILQAYCLV 206
Query: 181 QTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGL--------------- 225
V+I SN P G KT++L + G ++ N+ ++FG+ L
Sbjct: 207 TKGVRILCSNHTPKGAKTIVLQTHGDQEVMANISAIFGARQAADLVPLKSPFGQGQLTEA 266
Query: 226 ---ASIDVDLDLSNIRHTSILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYI 282
A ++ DL++ I E+ + N ++FQ++ G IS G GR+S+DRQ+ ++
Sbjct: 267 ELRADLESGADLADTTSPQISTEDVERLNQADFQLE--GFISSCRHGAGRSSRDRQFFFV 324
Query: 283 NKRPVDYPKVAKTINETYQSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVL 342
N RP D +AK +NE Y +N Q P L+ +D+N+TPDKR + ++ E +L
Sbjct: 325 NSRPCDPKNIAKVMNEVYHRYNVQQQPFIYLNIITARSDVDVNLTPDKRQLLINNERILL 384
Query: 343 DALRESLQLFFQKQGFVVPKSETTSDNPFGPKRIKVEPLDASTLHNSENSKIISNGNHLR 402
AL++SL F + TT + PK T E+SK +
Sbjct: 385 LALKKSLLDTFGQTPATFQMQNTTIVSMLEPK-----TNSGKTKFPKESSK------DDQ 433
Query: 403 HPTIIKDEV--HELPRLISPL-----------RSPTLAKMKGESEQSELKSSTVETEDLD 449
H + +++V R + L +P++ + SE EL + T++ + +
Sbjct: 434 HEEVSEEDVPTTSTQRFMDVLTQWRRTGDTKGTAPSVPVKRRCSESEELVTRTLKMQKIH 493
Query: 450 DGFDDKLHNHRESVHKDEISANNHLDYVAED---VNTGPHLLNPHEKEGDTKRLFVDSDL 506
+ N + S + E A + +D +D V+ LN E +++ + +
Sbjct: 494 TFLSQESPNEQSSKCEAESDAASDVDMAKKDKTQVSLDNSFLNLKELAKESEAYDLLTKP 553
Query: 507 ENTIESESNVISKELDESEDVDIDKNNLKVTPKGNHIQLGDFLHRRMSNVDIEKSPVEVD 566
+NT + V+ TP + + +F M+ +D ++SP E++
Sbjct: 554 QNTPRIDCKVL-------------------TPIKSRRSIFEFKTDAMA-LDKQESPAELN 593
Query: 567 ELVVQIDNNISTIPASQDRDNKLVFHPHTSHSGNDSCRHSHNHSPNESDYSDDDFENGTD 626
+ D D+ H P ++ D++ E G
Sbjct: 594 SQPPSFTQLSEETDIASDEDD-------------------HIELPTRIEF-DEEMEEGLP 633
Query: 627 IVFKNTVENESDLEQIKKQIEGSSSESLSLHQINNLVTSVRASLKIEAEKSQKVVCAIEI 686
F ++ E + LE+I + SL H+ R L Q++ EI
Sbjct: 634 SNF-SSGEITTSLEEI--------ASSLKAHEQQQRDRRTRTKL-------QRLRFKTEI 677
Query: 687 DKAIKHERLVNEIASIDDKEKAEHLLTLTVSKNDFQNMTIVGQFNLGFIIVTRCKEGAFD 746
+ + AE L + K DF M I+GQFNLGFIIV + D
Sbjct: 678 NP--------------NQNTSAEAELQREIDKEDFARMEIIGQFNLGFIIV----KLEDD 719
Query: 747 LFIVDQHASDEKYNFEMLQKNTVFKSQSLLSLKTLELSVIDELLVMEYKDVFSKNGFKLS 806
LFIVDQHA+DEKYNFE LQ+ T + Q L + LEL+ ++E++++ + DVF KNGFK
Sbjct: 720 LFIVDQHATDEKYNFETLQRTTQLEYQRLAVPQNLELTAVNEMVLLNHIDVFEKNGFKFE 779
Query: 807 IDQEEEPGQRIKLVSFPVSKNTMFTEYDFHELIQLIREHEGHDMSNIRCSKIRSMFAMRA 866
+D E ++++L+ P SK F + D ELI +++ + + + R S++R+MFA RA
Sbjct: 780 VDHEAPATKKVRLLGKPHSKRWEFGKEDIDELIFMLQ--DAPEGTICRPSRVRAMFASRA 837
Query: 867 CRSSIMIGKPLSMR-TMKKVVNNLSDLEKPWNCPHGRPTLRHLMEL 911
CR S+MIG LS TM++++ + ++E+PWNCPHGRPT+RHL+ +
Sbjct: 838 CRKSVMIGTALSRNTTMRRLITQMGEIEQPWNCPHGRPTMRHLINI 883
>Hs4505913 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 862
Score = 416 bits (1070), Expect = e-116
Identities = 289/914 (31%), Positives = 461/914 (49%), Gaps = 77/914 (8%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ I+ +H+I SGQV++ L +A+KEL+ENSLDA A I++ K+YG++ IE +DNG G
Sbjct: 15 IKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCG 74
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPKA-YK 121
+ E++ + + KH TSKI F D+++V +FGFRGEA++SLC + V I+T K +
Sbjct: 75 VEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTR 134
Query: 122 IVFNHSGTC-NKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAII 180
++F+H+G K R GTTV V LF TLPVR K+F +N K+++ + + ++ +Y II
Sbjct: 135 LMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCII 194
Query: 181 QTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHT 240
+++S +N L GK+ ++ + G I N+ SVFG + L V L S+
Sbjct: 195 SAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPF-VQLPPSD---- 249
Query: 241 SILPENQKE-ENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINET 299
S+ E +A I+G IS + G GR+S DRQ+ +IN+RP D KV + +NE
Sbjct: 250 SVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEV 309
Query: 300 YQSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQLFFQKQGFV 359
Y +N QYP VL+ V ++ +D+NVTPDKR + L E+ +L L+ SL F
Sbjct: 310 YHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMF------ 363
Query: 360 VPKSETTSDNPFGPKRIKVEPLDASTLHNSENSKIISNGNHLRHPTIIKDEVHELPRLIS 419
D+ + +PL + E + I + L P + K +
Sbjct: 364 --------DSDVNKLNVSQQPL-----LDVEGNLIKMHAADLEKPMVEKQD--------- 401
Query: 420 PLRSPTLAKMKGESEQSELKSSTVETEDLDDGFDDKLHNHR--ESVHKDEISANNHLDYV 477
+SP+L GE ++ S E L ++K H+ + E L
Sbjct: 402 --QSPSLRT--GEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSS 457
Query: 478 AEDVNTGPHLLNPHEKEGDTKRLFVDSDLENTIESESNVISKELDESEDVDIDKNNLKVT 537
+ +L P ++ + D +E +S S +D SE I +
Sbjct: 458 TSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVD-SEGFSIPDTGSHCS 516
Query: 538 PKGNHIQLGDFLHRRMSNVDIEKSPVEVDELVVQIDNNISTIPASQDRDNKLVFHPHTSH 597
+ GD +VD ++ E D+ +D + + +D K P ++
Sbjct: 517 SEYAASSPGD--RGSQEHVDSQEKAPETDDSFSDVDCHSN----QEDTGCKFRVLPQPTN 570
Query: 598 SGNDSCRHSHNHSPNESDYSDDDFENGTDIVFKNTVENESDLEQIKKQIEGSSSESLSLH 657
+PN + ++ + +DI K + Q+ ++
Sbjct: 571 LA----------TPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVK---------- 610
Query: 658 QINNLVTSVRASLKIEAEKSQKVVCAIEIDKAIKHERLVNEIASIDDKEKAEHLLTLTVS 717
IN V + S+ A++ +++ + + ++ R + + AE L +S
Sbjct: 611 -INKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEIS 669
Query: 718 KNDFQNMTIVGQFNLGFIIVTRCKEGAFDLFIVDQHASDEKYNFEMLQKNTVFKSQSLLS 777
K F M I+GQFNLGFII T+ E D+FIVDQHA+DEKYNFEMLQ++TV + Q L++
Sbjct: 670 KTMFAEMEIIGQFNLGFII-TKLNE---DIFIVDQHATDEKYNFEMLQQHTVLQGQRLIA 725
Query: 778 LKTLELSVIDELLVMEYKDVFSKNGFKLSIDQEEEPGQRIKLVSFPVSKNTMFTEYDFHE 837
+TL L+ ++E +++E ++F KNGF ID+ +R KL+S P SKN F D E
Sbjct: 726 PQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDE 785
Query: 838 LIQLIREHEGHDMSNIRCSKIRSMFAMRACRSSIMIGKPLSMRTMKKVVNNLSDLEKPWN 897
LI ++ + G R S+++ MFA RACR S+MIG L+ MKK++ ++ +++ PWN
Sbjct: 786 LIFMLSDSPG---VMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWN 842
Query: 898 CPHGRPTLRHLMEL 911
CPHGRPT+RH+ L
Sbjct: 843 CPHGRPTMRHIANL 856
>SPAC19G12.02c [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 794
Score = 264 bits (674), Expect = 5e-70
Identities = 147/368 (39%), Positives = 226/368 (60%), Gaps = 29/368 (7%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
++ I+ +HKI SGQVI D+ SA+KEL+ENSLD+ A IEI FKNYGI SIE DNG G
Sbjct: 4 VKPIDANTVHKICSGQVITDVASAVKELVENSLDSGATTIEIRFKNYGINSIEVVDNGSG 63
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTT--KGPKAY 120
I D +++G+KH TSKI+ FED+ + +FGFRGEA++SLC +G+VII+T T + PK
Sbjct: 64 IDAGDYESIGKKHFTSKITDFEDLEALQTFGFRGEALSSLCAVGQVIISTATQNEAPKGV 123
Query: 121 KIVFNHSGTC-NKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAI 179
++ +H G+ +K+ GT+V+V++LF TLPVR+K KNYKR+F+++I L+Q+YA
Sbjct: 124 QLNLDHEGSLKDKLTIPFQRGTSVMVNDLFCTLPVRRKLLEKNYKREFSKAISLLQAYAT 183
Query: 180 IQTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRH 239
I TN + V + + K L LS+ D+ N+++VFG+
Sbjct: 184 ISTNKRFMVYHQTKNSGKLLQLSTNSNKDMKLNIMNVFGTKVS----------------- 226
Query: 240 TSILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINET 299
+S++P N I G IS G RAS +RQ ++IN+R V+ PK+A+ I E
Sbjct: 227 SSLIPWNDG---------IIEGYISRPHVGSTRASNERQMLFINRRLVNLPKIARVIQEV 277
Query: 300 YQSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQLFFQKQGFV 359
++ ++ Q P F ++ R+ +D+NV+PDK++V L E+ +++ ++ SLQ + G
Sbjct: 278 FKPYSMAQSPFFAINLRITNGTIDINVSPDKKSVFLSEEDSIIEFIKNSLQNLCESCGHA 337
Query: 360 VPKSETTS 367
+ S + S
Sbjct: 338 ISCSRSQS 345
Score = 194 bits (492), Expect = 7e-49
Identities = 98/230 (42%), Positives = 145/230 (62%), Gaps = 8/230 (3%)
Query: 684 IEIDKAIKHERLVNEIASIDDKEKAEHLLTLTVSKNDFQNMTIVGQFNLGFIIVTRCKEG 743
+ D +K + + I D+ + +HL LTV K DF M +VGQFN GFI+V
Sbjct: 572 VRSDALLKFSNKIGVVHDISDENQEDHL-NLTVHKADFLRMRVVGQFNRGFIVVVHGN-- 628
Query: 744 AFDLFIVDQHASDEKYNFEMLQKNTVFKSQSLLSLKTLELSVIDELLVMEYKDVFSKNGF 803
+LFI+DQHASDEK+N+E L+ N V SQ L+ K L+L+ +E +++++ D+ + GF
Sbjct: 629 --NLFIIDQHASDEKFNYEHLKSNLVINSQDLVLPKRLDLAATEETVLIDHIDLIRRKGF 686
Query: 804 KLSIDQEEEPGQRIKLVSFPVSKNTMFTEYDFHELIQLIREHEGHDMSNIRCSKIRSMFA 863
++ID + G R L+S P SKN +F D E+I ++ EH D + S++ M A
Sbjct: 687 GVAIDLNQRVGNRCTLLSVPTSKNVIFDTSDLLEIISVLSEHPQIDPFS---SRLERMLA 743
Query: 864 MRACRSSIMIGKPLSMRTMKKVVNNLSDLEKPWNCPHGRPTLRHLMELKD 913
+ACRSS+MIG+ L++ M +V +L++L KPWNCPHGRPT+RHL+ LKD
Sbjct: 744 SKACRSSVMIGRALTISEMNTIVRHLAELSKPWNCPHGRPTMRHLLRLKD 793
>CE19915 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 805
Score = 235 bits (600), Expect = 2e-61
Identities = 174/554 (31%), Positives = 279/554 (49%), Gaps = 41/554 (7%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ I ++T+ QV+V L SAI++L++NS+DA + I+I KN G ESIE DNG G
Sbjct: 6 IERISKEVAERLTTAQVVVSLSSAIRQLIDNSIDAGSTIIDIRVKNNGFESIEVQDNGSG 65
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPK-AYK 121
I + D + + H TSK++ F D K+ + GFRGEA+ +LC + V I T + +
Sbjct: 66 IEARNFDALCKPHSTSKLTQFSDFDKLATLGFRGEALNALCTVSSVSIFTRASDTEIGTR 125
Query: 122 IVFNHSGTCNKIIC----SRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSY 177
+ ++HSG IIC +R GTT++V+ LF+TLPVR+K+ ++ KR+F + + +QS+
Sbjct: 126 LTYDHSGN---IICRQSAARELGTTIIVNKLFETLPVRRKELERSQKREFVKLLSTVQSF 182
Query: 178 AIIQTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFG-------SNAGKGLASIDV 230
A++ ++KI +N + K LI + G + I + ++FG S G GL I
Sbjct: 183 ALLCPHIKILCTNNINGKKTNLICTPGGTTSIQDVVANLFGIARKIENSKIGSGLIPIQQ 242
Query: 231 DLDLSNIRHTSILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYP 290
+ I +P EE KI G +S GCGR + DRQ+VYIN RPV+Y
Sbjct: 243 NQPDVEIMTIHSVP---MEEMHFFDLFKIRGFVSSCEHGCGRGTSDRQFVYINNRPVEYS 299
Query: 291 KVAKTINETYQSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQ 350
+V IN+ Y+ FN QYP VL V + +D+NVTPDK+TV L E ++L +R S+
Sbjct: 300 RVCSVINDVYKQFNKKQYPIIVLFIDVPPEKIDVNVTPDKKTVMLEKERHLLAVVRASMM 359
Query: 351 LFFQKQGFVVPKSETTSDNPFGPKRI---KVEPLDASTLHNSENSKIISNGNHLRHPTII 407
+ K + S +T + +RI + ++ +S++S N + T
Sbjct: 360 KTYLK----IVGSHSTVRSSVEDRRIMNLSQQSFSNASFMSSKSSTPDDFNNTTLNSTYP 415
Query: 408 KDEVHELPRLISPL---RSPTLAK-----MKGESEQSELKSSTVETEDLDDGFDDKLHNH 459
+D + L+ RSP K + E S +S T+ L++ F +
Sbjct: 416 EDSLLNTSDLLKQRKENRSPPAKKSCPMIRRTEPFHSVPSTSNSRTQRLEN-FSFTMEPK 474
Query: 460 RESVHKDEISANNHLDYVAEDVNTGPHLLNPHEKEGDTKRLFVDSDLENTIESESNVISK 519
R V K +I + + E++ + NP +K G+ D+E +S+ +
Sbjct: 475 RVEVSK-KIPSKSDKKLTDEELRSAVIEENPLKKAGEI------DDIEILEQSQESQDVN 527
Query: 520 ELDESEDVDIDKNN 533
E S+D +N+
Sbjct: 528 ESQCSQDSQTSQNS 541
Score = 167 bits (423), Expect = 7e-41
Identities = 101/286 (35%), Positives = 152/286 (52%), Gaps = 11/286 (3%)
Query: 635 NESDLEQIKKQIEGSSSESLSLHQINNLVTSVRASLKIEAEKSQKVVCAIEIDKAIKHER 694
NES Q + + S +L + S++ + + K+ + E + +
Sbjct: 527 NESQCSQDSQTSQNSRVSYFTLRPQQKIKFSMKLLREAYSPKTDETDDNTEEAEVSAEKD 586
Query: 695 LVNEIASIDDKEK---AEHLLTLTVSKNDFQNMTIVGQFNLGFIIVTRCKEGAFDLFIVD 751
++NEI + +KE+ AE L+ +++K+DF M I+GQFN GFII C+ LFIVD
Sbjct: 587 VLNEITTKINKEENDDAERQLSRSLTKDDFSKMKIIGQFNHGFII---CRLRGH-LFIVD 642
Query: 752 QHASDEKYNFEMLQKNTVFKSQSLLSLKTLELSVIDELLVMEYKDVFSKNGFKLSIDQEE 811
QHASDEKYNFE LQ + Q L L + EL++ E +F NGF E
Sbjct: 643 QHASDEKYNFERLQSSAKLTKQPLFMPTALGFGAVQELIIRENLPIFHANGFDFEFS-EN 701
Query: 812 EPGQRIKLVSFPVSKNTMFTEYDFHELIQLIREHEGHDMSNIRCSKIRSMFAMRACRSSI 871
+ + L + P N T D E++ ++ ++ +R IR +FA +ACR S+
Sbjct: 702 DGCIKTFLTARPELLNQQLTNSDLEEILAVVSQYPNQMYRPVR---IRKIFASKACRKSV 758
Query: 872 MIGKPLSMRTMKKVVNNLSDLEKPWNCPHGRPTLRHLMELKDWDSF 917
MIGKPL+ R M +++ +L+ L++PWNCPHGRPT+RHL L D F
Sbjct: 759 MIGKPLNQREMTQIIRHLAKLDQPWNCPHGRPTIRHLASLPDRAEF 804
>At4g02460 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 779
Score = 232 bits (592), Expect = 2e-60
Identities = 143/384 (37%), Positives = 206/384 (53%), Gaps = 58/384 (15%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ I IH+I SGQVI+DL SA+KEL+ENSLDA A IEI ++YG + + DNG G
Sbjct: 17 IRPINRNVIHRICSGQVILDLSSAVKELVENSLDAGATSIEINLRDYGEDYFQVIDNGCG 76
Query: 63 ISEDDL-----------DNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIIT 111
IS + D + KH TSK+ F D+ +T++GFRGEA++SLC +G + +
Sbjct: 77 ISPTNFKVCVQILRRTFDVLALKHHTSKLEDFTDLLNLTTYGFRGEALSSLCALGNLTVE 136
Query: 112 TTTKG-PKAYKIVFNHSG--TCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFN 168
T TK P A + F+HSG T K +R GTTV V LF LPVR K+F +N ++++
Sbjct: 137 TRTKNEPVATLLTFDHSGLLTAEKKT-ARQIGTTVTVRKLFSNLPVRSKEFKRNIRKEYG 195
Query: 169 RSIDLIQSYAIIQTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASI 228
+ + L+ +YA+I V+ SN K+++L++ G+ + N+++VFG +
Sbjct: 196 KLVSLLNAYALIAKGVRFVCSNTTGKNPKSVVLNTQGRGSLKDNIITVFGIST------- 248
Query: 229 DVDLDLSNIRHTSILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVD 288
TS+ P G GR DRQY +IN RPVD
Sbjct: 249 ----------FTSLQP------------------------GTGRNLADRQYFFINGRPVD 274
Query: 289 YPKVAKTINETYQSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRES 348
PKV+K +NE Y+ ++ +YP +LDF V DLNVTPDKR V E V+ +LRE
Sbjct: 275 MPKVSKLVNELYKDTSSRKYPVTILDFIVPGGACDLNVTPDKRKVFFSDETSVIGSLREG 334
Query: 349 LQLFFQKQ--GFVVPKSETTSDNP 370
L + ++V + E S+ P
Sbjct: 335 LNEIYSSSNASYIVNRFEENSEQP 358
Score = 175 bits (444), Expect = 3e-43
Identities = 104/263 (39%), Positives = 151/263 (56%), Gaps = 21/263 (7%)
Query: 675 EKSQKVVCAIEIDKAIKHERLVNEIASIDDKEKAEHLLTL-------TVSKNDFQNMTIV 727
EKS+ V A+ ++ ++L + + S +D +E L T + N ++ ++
Sbjct: 505 EKSKFEVRALASRCLVEGDQLDDMVISKEDMTPSERDSELGNRISPGTQADNVERHERVL 564
Query: 728 GQFNLGFIIVTRCKEGAFDLFIVDQHASDEKYNFEMLQKNTVFKSQSLLSLKTLELSVID 787
GQFNLGFII + DLFIVDQHA+DEK+NFE L ++TV Q LL LELS +
Sbjct: 565 GQFNLGFIIAKLER----DLFIVDQHAADEKFNFEHLARSTVLNQQPLLQPLNLELSPEE 620
Query: 788 ELLVMEYKDVFSKNGFKLSIDQEEEPGQRIKLVSFPVSKNTMFTEYDFHELIQLIREHEG 847
E+ V+ + D+ +NGF L + PG+ +L + P SKN F D +LI + ++ G
Sbjct: 621 EVTVLMHMDIIRENGFLLEENPSAPPGKHFRLRAIPYSKNITFGVEDLKDLISTLGDNHG 680
Query: 848 H----------DMSNIRCSKIRSMFAMRACRSSIMIGKPLSMRTMKKVVNNLSDLEKPWN 897
+I S++R+M A RACRSS+MIG PL M+K+V +L+DLE PWN
Sbjct: 681 ECSVASSYKTSKTDSICPSRVRAMLASRACRSSVMIGDPLRKNEMQKIVEHLADLESPWN 740
Query: 898 CPHGRPTLRHLMELKDWDSFCDD 920
CPHGRPT+RHL++L + DD
Sbjct: 741 CPHGRPTMRHLVDLTTLLTLPDD 763
>Hs4505911 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 932
Score = 171 bits (432), Expect = 6e-42
Identities = 235/985 (23%), Positives = 409/985 (40%), Gaps = 141/985 (14%)
Query: 9 ADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVGISEDDL 68
A + ++S Q+I + S +KEL+ENSLDA A +++ +NYG + IE DNG GI D
Sbjct: 7 ATVRLLSSSQIITSVVSVVKELIENSLDAGATSVDVKLENYGFDKIEVRDNGEGIKAVDA 66
Query: 69 DNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPK-AYKIVFNHS 127
+ K+ TSKI+S ED+ +T++GFRGEA+ S+C + +V+ITT T + + V + S
Sbjct: 67 PVMAMKYYTSKINSHEDLENLTTYGFRGEALGSICCIAEVLITTRTAADNFSTQYVLDGS 126
Query: 128 G-TCNKIICSRNTGTTVLVSNLFDTLPVRKKDF--IKNYKRQFNRSIDLIQSYAIIQTNV 184
G ++ GTTV LF LPVRK+ + K K + + DL+ S+ I++ ++
Sbjct: 127 GHILSQKPSHLGQGTTVTALRLFKNLPVRKQFYSTAKKCKDEIKKIQDLLMSFGILKPDL 186
Query: 185 KISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHTSILP 244
+I + K +I SD L+SV G+ + S + S I + LP
Sbjct: 187 RIVFVH-----NKAVIWQKSRVSDHKMALMSVLGTAVMNNMESFQYHSEESQIYLSGFLP 241
Query: 245 ENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINETYQ--- 301
+ + + + ++ +R +++IN RPV + K I Y
Sbjct: 242 KCDADHSFTSL-----------------STPERSFIFINSRPVHQKDILKLIRHHYNLKC 284
Query: 302 -SFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALR-------------- 346
+ YP F L V T +D+N+TPDK V L +E VL AL
Sbjct: 285 LKESTRLYPVFFLKIDVPTADVDVNLTPDKSQVLLQNKESVLIALENLMTTCYGPLPSTN 344
Query: 347 --ESLQLFFQKQGFVVPKSETT---------SDNPFGPKRIKVEPLDASTLHNSENSKII 395
E+ + V+ K+ T S + V P + +HN E+ K
Sbjct: 345 SYENNKTDVSAADIVLSKTAETDVLFNKVESSGKNYSNVDTSVIPFQ-NDMHNDESGK-- 401
Query: 396 SNGNHLRHPTIIKD--------EVHELPR-LISPLRSPTLAKMKGESEQSELKS----ST 442
+ + L H I D E+ + + + + +++ + E+ Q+E S+
Sbjct: 402 NTDDCLNHQISIGDFGYGHCSSEISNIDKNTKNAFQDISMSNVSWENSQTEYSKTCFISS 461
Query: 443 VETEDLDDGFDDKLHNHRESVHKDEISANNHLDYVAEDVNTGPHLLNP-HEKEGDTKRLF 501
V+ ++G +K H +++E N + A++ + G L N E K L
Sbjct: 462 VKHTQSENG--NKDHIDESGENEEEAGLENSSEISADEWSRGNILKNSVGENIEPVKILV 519
Query: 502 VDSDLENTIESESNVISKELDESEDVDIDKNNLKVTPKGNHIQLGDFLHRRMSNVDIEKS 561
+ L + + + I ++++ +ED K+N+ + K + D L R + K
Sbjct: 520 PEKSLPCKVSNNNYPIPEQMNLNEDSCNKKSNV-IDNKSGKVTAYDLLSNR-----VIKK 573
Query: 562 PVEVDELVVQIDNNISTIPASQDRDNKLVFHPHTSHSGNDSCRH--------SHNHSPNE 613
P+ L VQ R L+ +P TS D+ S
Sbjct: 574 PMSASALFVQ-----------DHRPQFLIENPKTSL--EDATLQIEELWKTLSEEEKLKY 620
Query: 614 SDYSDDDFENGTDIVFKNTVENES--DLEQIKKQIEGSSSESLSLHQINNLVTSVRASLK 671
+ + D E + K +E ES L+ +K+I+ +S+ +L+ Q + L TS+ K
Sbjct: 621 EEKATKDLER-YNSQMKRAIEQESQMSLKDGRKKIKPTSAWNLA--QKHKLKTSLSNQPK 677
Query: 672 --------IEAEKSQKVVCAIEIDKAIKHERL-VNEIASIDDKEKAEHLLTLTVSKNDFQ 722
IE +SQ + ++I ++K+ ++ + +D +EK E L + D
Sbjct: 678 LDELLQSQIEKRRSQNIK-MVQIPFSMKNLKINFKKQNKVDLEEKDEPCLIHNLRFPDAW 736
Query: 723 NMTIVGQFNLGFIIVTRCKEGAFDLFIVDQHASDEKYNFEMLQKNTVFKSQSLLSLKTLE 782
MT + + + R +E +++ H K E L+K + ++SL +
Sbjct: 737 LMT--SKTEVMLLNPYRVEEALLFKRLLENH----KLPAEPLEK-PIMLTESLFN----G 785
Query: 783 LSVIDELLVMEYKDVFSKNGFKLSIDQEEEPGQRIKLV-SFPVSKNTMFTE--------- 832
+D L M D LS + G +IKL+ +++N + E
Sbjct: 786 SHYLDVLYKMTADDQRYSGSTYLSDPRLTANGFKIKLIPGVSITENYLEIEGMANCLPFY 845
Query: 833 --YDFHELIQLIREHEGHDMSNIRCSKIRSMFAMRACRSSIMIGKPLSMRTMKKVVNNLS 890
D E++ I ++ R K+ S A R S + LS ++ ++ +
Sbjct: 846 GVADLKEILNAILNRNAKEVYECRPRKVISYLEGEAVRLSRQLPMYLSKEDIQDIIYRMK 905
Query: 891 DL--EKPWNCPHGRPTLRHLMELKD 913
+ C HGRP HL L +
Sbjct: 906 HQFGNEIKECVHGRPFFHHLTYLPE 930
>Hs4557757 [L] KOG1979 DNA mismatch repair protein - MLH1 family
Length = 756
Score = 149 bits (376), Expect = 2e-35
Identities = 98/351 (27%), Positives = 180/351 (50%), Gaps = 30/351 (8%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ ++ +++I +G+VI +AIKE++EN LDAK+ I++I K G++ I+ DNG G
Sbjct: 8 IRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTG 67
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITT-TTKGPKAYK 121
I ++DLD V ++ TSK+ SFED++ ++++GFRGEA+AS+ + V ITT T G AY+
Sbjct: 68 IRKEDLDIVCERFTTSKLQSFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYR 127
Query: 122 IVFNHSG-TCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAII 180
++ C+ N GT + V +LF + R+K +KN ++ + ++++ Y++
Sbjct: 128 ASYSDGKLKAPPKPCAGNQGTQITVEDLFYNIATRRK-ALKNPSEEYGKILEVVGRYSVH 186
Query: 181 QTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHT 240
+ SV G+ + ++ + N+ S+FG+ + L I
Sbjct: 187 NAGISFSVKK---QGETVADVRTLPNASTVDNIRSIFGNAVSRELIEIGC---------- 233
Query: 241 SILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINETY 300
E+ F K+ G IS ++ K ++IN R V+ + K I Y
Sbjct: 234 --------EDKTLAF--KMNGYISNANYS---VKKCIFLLFINHRLVESTSLRKAIETVY 280
Query: 301 QSF-NNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQ 350
++ +P L + + +D+NV P K V +EE +L+ +++ ++
Sbjct: 281 AAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIE 331
>At4g09140 [L] KOG1979 DNA mismatch repair protein - MLH1 family
Length = 737
Score = 141 bits (355), Expect = 5e-33
Identities = 130/512 (25%), Positives = 238/512 (46%), Gaps = 55/512 (10%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
IQ +E + +++I +G+VI SA+KEL+ENSLDA + I ++ K+ G++ I+ +D+G G
Sbjct: 29 IQRLEESVVNRIAAGEVIQRPVSAVKELVENSLDADSSSISVVVKDGGLKLIQVSDDGHG 88
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGP-KAYK 121
I +DL + ++H TSK++ FED+ ++S GFRGEA+AS+ + V +TT TKG Y+
Sbjct: 89 IRREDLPILCERHTTSKLTKFEDLFSLSSMGFRGEALASMTYVAHVTVTTITKGQIHGYR 148
Query: 122 IVFNHSGTCNKI-ICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAII 180
+ + ++ C+ GT ++V NLF + R+K ++N + + +DL+ AI
Sbjct: 149 VSYRDGVMEHEPKACAAVKGTQIMVENLFYNMIARRKT-LQNSADDYGKIVDLLSRMAIH 207
Query: 181 QTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHT 240
NV S G + S+ ++ SV+G + K L ++V
Sbjct: 208 YNNVSFSCRK---HGAVKADVHSVVSPSRLDSIRSVYGVSVAKNLMKVEV---------- 254
Query: 241 SILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINETY 300
+ + + F ++ G IS ++ A K ++IN R V+ + + I Y
Sbjct: 255 -----SSCDSSGCTFDME--GFISNSNYV---AKKTILVLFINDRLVECSALKRAIEIVY 304
Query: 301 QS-FNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQL-------- 351
+ P + + + +D+N+ P K+ VSL +E +++ ++ +++
Sbjct: 305 AATLPKASKPFVYMSINLPREHVDINIHPTKKEVSLLNQEIIIEMIQSEVEVKLRNANDT 364
Query: 352 -FFQKQGFVVPKSETTSDNPFGPKRIKVEPLDASTLHNSENSKIISNGNHLRHPTIIKDE 410
FQ+Q +S TS P K + ++ + S+ R ++ +
Sbjct: 365 RTFQEQKVEYIQSTLTSQKSDSPVSQKPSGQKTQKVPVNKMVRTDSSDPAGRLHAFLQPK 424
Query: 411 VHELPRLISPLR--SPTLAKMKGESEQSELKSSTVETEDLDDGFDDKLH-NHRESVHK-- 465
LP +S L ++ + + E ++L S ++L G D H E+V
Sbjct: 425 PQSLPDKVSSLSVVRSSVRQRRNPKETADLSS----VQELIAGVDSCCHPGMLETVRNCT 480
Query: 466 -----DEISA----NNHLDYVAEDVNTGPHLL 488
D++ A N HL Y+A VN L+
Sbjct: 481 YVGMADDVFALVQYNTHL-YLANVVNLSKELM 511
>ECU11g1260 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 630
Score = 140 bits (354), Expect = 7e-33
Identities = 80/197 (40%), Positives = 114/197 (57%), Gaps = 15/197 (7%)
Query: 714 LTVSKNDFQNMTIVGQFNLGFIIVTRCKEGAFDLFIVDQHASDEKYNFEMLQKNTVFKSQ 773
++ SK DF + I+GQFN GFII K L VDQHA+DE NFE ++K K Q
Sbjct: 446 ISFSKGDFGRLEIIGQFNNGFIITKLEKNKKTYLVAVDQHAADEIRNFEDIKKTFCLKKQ 505
Query: 774 SLLSLKTLELSVIDELLVMEYKDVFSKNGFKLSIDQEEEPGQRIKLVSFPVSKNTMFTEY 833
S++S L+L+ I+E++V + ++F +NGF + L + PV KN F
Sbjct: 506 SVISPVKLDLTPIEEMVVSDNVELFERNGFVVKDGM---------LETVPVYKNQTFGIR 556
Query: 834 DFHELIQLIREHEGHDMSNIRCSKIRSMFAMRACRSSIMIGKPLSMRTMKKVVNNLSDLE 893
+F EL++ ++ E K RS+ A +ACR+S+MIG LSM MK++V +L+ LE
Sbjct: 557 EFRELLEDVKNEE------YEFRKARSIIASKACRTSVMIGDVLSMADMKRIVKSLASLE 610
Query: 894 KPWNCPHGRPTLRHLME 910
+PW CPHGRPT L E
Sbjct: 611 RPWKCPHGRPTFMVLNE 627
Score = 91.3 bits (225), Expect = 6e-18
Identities = 94/357 (26%), Positives = 157/357 (43%), Gaps = 57/357 (15%)
Query: 13 KITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVGISEDDLDNVG 72
+I + + + + +KEL+EN++D+ I I+ ++I DNG GIS DLD VG
Sbjct: 12 RIRAQRSVQSIYIVVKELIENAIDSGCTWIRILVD----DAITVEDNGCGIS--DLDKVG 65
Query: 73 QKHRTSKIS------SFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPKAYKIVFNH 126
+ TSK S + D + S+GFRG+A++ L ++ + I + ++ A + F+
Sbjct: 66 VEGATSKESMAYYVLGYADRVEKFSYGFRGQALSCLAEVCDLEIISRSEHSFALRKDFST 125
Query: 127 SGTCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAIIQTNVKI 186
+ C+R GTTV V NLF P+R+ KR + LI+SY KI
Sbjct: 126 NAISK---CARERGTTVHVRNLFKNCPLRRPMADSGLKRDLGKICSLIESYRCAN---KI 179
Query: 187 SVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHTSILPEN 246
N K+ ++LS G + S + S AGK + + +DL +LP
Sbjct: 180 ---NFTLFHKRKVLLSCGGYETVREYFESNYPSFAGKCMEVCNGQMDL------FMLPVC 230
Query: 247 QKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINETYQSFNNV 306
KE +Q ++ +RP+ ++ + + +
Sbjct: 231 VKE--------------------------PKQLMFSERRPISNRRILNAVKSEFGLYVEG 264
Query: 307 QYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQLFFQKQGFVVPKS 363
P+FVL V + D+NV+ DK V E +L+ LR + FF + ++ P S
Sbjct: 265 S-PTFVL---VIKGYGDVNVSADKSEVIFADEAGILNLLRSEIGRFFSSEMYLNPAS 317
>SPBC1703.04 [L] KOG1979 DNA mismatch repair protein - MLH1 family
Length = 684
Score = 136 bits (343), Expect = 1e-31
Identities = 108/379 (28%), Positives = 182/379 (47%), Gaps = 43/379 (11%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ ++ I+KI +G++I +AIKEL+ENSLDA + I+++ K+ G++ ++ DNG G
Sbjct: 9 IRPLDQLVINKIAAGEIIERPENAIKELIENSLDAGSTSIDVLLKDGGLKLLQITDNGSG 68
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKV-IITTTTKGPKAYK 121
I DDL + Q+ TSKI +F D+ + +FGFRGEA+AS+ + KV ++T + A+K
Sbjct: 69 IQYDDLPYLCQRFSTSKIDNFNDLQHLQTFGFRGEALASISHVAKVTVVTKLSSDIHAWK 128
Query: 122 IVFNHSGTCNKII---------CSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSID 172
F G I C+ GT + +LF + R K +KN +F R +
Sbjct: 129 -AFYVDGALAPISPGMSPAPQPCAGKQGTVITAEDLFYNVRSR-KSALKNGSEEFRRIMI 186
Query: 173 LIQSYAIIQTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDL 232
L+Q YAI V + V + + S + K+D R+ ++G
Sbjct: 187 LVQKYAIHNDQVSFNCKKVGDTVASLSLSSRLSKADKIRH---IYGPRVA---------- 233
Query: 233 DLSNIRHTSILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKV 292
S++R S+ E +S G IS F + K ++IN R V+ ++
Sbjct: 234 --SHLRDFSL-----GEGQSSIVGFSANGFISNADF---QDKKSNLILFINNRLVESVEL 283
Query: 293 AKTINETYQSFNNVQYPSFV-LDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQL 351
+ ETY + + FV L + + LD+NV P KR V Y++ + ++ + L
Sbjct: 284 RHALEETYAKYLHKGASYFVYLSLNMSPEQLDVNVHPSKRIVHFLYDQEIATSICDKL-- 341
Query: 352 FFQKQGFVVPKSETTSDNP 370
G ++ +++T P
Sbjct: 342 -----GEILERTDTERSYP 355
>Hs4885551 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 389
Score = 132 bits (331), Expect = 3e-30
Identities = 71/167 (42%), Positives = 105/167 (62%), Gaps = 3/167 (1%)
Query: 3 IQAIENADIHKITSGQVIVDLR-SAIKELLENSLDAKADKIEIIFKNYGIESIECADNGV 61
I+ I+ +H+I SG V+ LR +A+KEL+ENSLDA A +++ K+YG++ IE + NG
Sbjct: 163 IKPIDRKSVHQICSGPVVPSLRPNAVKELVENSLDAGATNVDLKLKDYGVDLIEVSGNGC 222
Query: 62 GISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPK-AY 120
G+ E++ + KH T KI F D+++V +FGFRGEA++SLC + V I+T K
Sbjct: 223 GVEEENFEGFTLKHHTCKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCRVSAKVGT 282
Query: 121 KIVFNHSG-TCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQ 166
++VF+H G K R G TV V LF TLPV K+F +N K++
Sbjct: 283 RLVFDHYGKIIQKTPYPRPRGMTVSVKQLFSTLPVHHKEFQRNIKKK 329
>YMR167w [L] KOG1979 DNA mismatch repair protein - MLH1 family
Length = 769
Score = 130 bits (327), Expect = 9e-30
Identities = 90/351 (25%), Positives = 177/351 (49%), Gaps = 29/351 (8%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+A++ + ++KI +G++I+ +A+KE++ENS+DA A I+I+ K GI+ ++ DNG G
Sbjct: 5 IKALDASVVNKIAAGEIIISPVNALKEMMENSIDANATMIDILVKEGGIKVLQITDNGSG 64
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPK-AYK 121
I++ DL + ++ TSK+ FED+S++ ++GFRGEA+AS+ + +V +TT K + A++
Sbjct: 65 INKADLPILCERFTTSKLQKFEDLSQIQTYGFRGEALASISHVARVTVTTKVKEDRCAWR 124
Query: 122 IVFNHSGTCN--KIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAI 179
+ + K + ++ GTT+LV +LF +P R + ++++ ++++ +D++ YAI
Sbjct: 125 VSYAEGKMLESPKPVAGKD-GTTILVEDLFFNIPSRLR-ALRSHNDEYSKILDVVGRYAI 182
Query: 180 IQTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRH 239
++ S S + S D R + + K +AS + +S +
Sbjct: 183 HSKDIGFSCKKFGDSNYSLSVKPSYTVQDRIRTVFN-------KSVASNLITFHISKVED 235
Query: 240 TSILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINET 299
++ + K N + K I +IN R V + + +N
Sbjct: 236 LNLESVDGKVCNLNFISKKSISPI----------------FFINNRLVTCDLLRRALNSV 279
Query: 300 YQSF-NNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESL 349
Y ++ P L + +D+NV P KR V ++ +++ + L
Sbjct: 280 YSNYLPKGNRPFIYLGIVIDPAAVDVNVHPTKREVRFLSQDEIIEKIANQL 330
>7304079 [L] KOG1979 DNA mismatch repair protein - MLH1 family
Length = 664
Score = 129 bits (324), Expect = 2e-29
Identities = 90/351 (25%), Positives = 179/351 (50%), Gaps = 30/351 (8%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ ++ +++I +G++I +A+KELLENSLDA++ I++ K G++ ++ DNG G
Sbjct: 10 IRKLDEVVVNRIAAGEIIQRPANALKELLENSLDAQSTHIQVQVKAGGLKLLQIQDNGTG 69
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPK-AYK 121
I +DL V ++ TSK++ FED+S++ +FGFRGEA+AS+ + + I T T K YK
Sbjct: 70 IRREDLAIVCERFTTSKLTRFEDLSQIATFGFRGEALASISHVAHLSIQTKTAKEKCGYK 129
Query: 122 IVFNHSGTCNK-IICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAII 180
+ + C+ N GT + + +LF +P R++ +++ +F R +++ YA+
Sbjct: 130 ATYADGKLQGQPKPCAGNQGTIICIEDLFYNMPQRRQ-ALRSPAEEFQRLSEVLARYAVH 188
Query: 181 QTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHT 240
V ++ G L + S + N+ ++G+ K L
Sbjct: 189 NPRVGFTLRK---QGDAQPALRTPVASSRSENIRIIYGAAISKELL-------------- 231
Query: 241 SILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTINETY 300
E + +F+ + I+ V++ A K + ++IN+R V+ + +++ Y
Sbjct: 232 ----EFSHRDEVYKFEAECL--ITQVNYS---AKKCQMLLFINQRLVESTALRTSVDSIY 282
Query: 301 QSF-NNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQ 350
++ +P + + + LD+NV P K V Y+E ++D++++ ++
Sbjct: 283 ATYLPRGHHPFVYMSLTLPPQNLDVNVHPTKHEVHFLYQEEIVDSIKQQVE 333
>Hs22046611 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 199
Score = 116 bits (290), Expect = 2e-25
Identities = 61/139 (43%), Positives = 89/139 (63%), Gaps = 2/139 (1%)
Query: 30 LLENSLDAKADKIEIIFKNYGIESIECADNGVGISEDDLDNVGQKHRTSKISSFEDVSKV 89
++ENSLDA A I++ K+YG++ IE + NG G+ E++ + + KH TSKI F D+++V
Sbjct: 1 MVENSLDAGATNIDLKLKDYGMDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLTRV 60
Query: 90 TSFGFRGEAIASLCQMGKVIITTTTKGPK-AYKIVFNHSG-TCNKIICSRNTGTTVLVSN 147
+FGFRGEA++SLC + V I+T K ++VF+H G K GTTV V
Sbjct: 61 ETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHDGKIIQKTPYPHPRGTTVSVKQ 120
Query: 148 LFDTLPVRKKDFIKNYKRQ 166
LF TLPVR K+F +N K++
Sbjct: 121 LFSTLPVRHKEFQRNIKKK 139
>CE18978 [L] KOG1979 DNA mismatch repair protein - MLH1 family
Length = 779
Score = 100 bits (250), Expect = 8e-21
Identities = 91/353 (25%), Positives = 166/353 (46%), Gaps = 36/353 (10%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
IQ + ++++ +G+V+ +AIKEL+ENSLDA A +I + +N G++ ++ +DNG G
Sbjct: 25 IQRLPQDVVNRMAAGEVLARPCNAIKELVENSLDAGATEIMVNMQNGGLKLLQVSDNGKG 84
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPK-AYK 121
I +D V ++ TSK+ FED+ + ++GFRGEA+ASL + KV I + K AY+
Sbjct: 85 IEREDFALVCERFATSKLQKFEDLMHMKTYGFRGEALASLSHVAKVNIVSKRADAKCAYQ 144
Query: 122 IVF-NHSGTCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAII 180
F + T + + GT + ++LF LP R+ + + + D + +AI
Sbjct: 145 ANFLDGKMTADTKPAAGKNGTCITATDLFYNLPTRRNK-MTTHGEEAKMVNDTLLRFAIH 203
Query: 181 QTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHT 240
+ +V ++ +T K D N V + G+ +A + L L
Sbjct: 204 RPDVSFALRQNQAGDFRT-------KGD--GNFRDVVCNLLGRDVADTILPLSL------ 248
Query: 241 SILPENQKEENASEFQVKITGQISM-VSFGCGRASKDRQ------YVYINKRPVDYPKVA 293
N++ + TG IS ++ +++R+ V+IN R V +
Sbjct: 249 ----------NSTRLKFTFTGHISKPIASATAAIAQNRKTSRSFFSVFINGRSVRCDILK 298
Query: 294 KTINETYQSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALR 346
I+E + + L ++ +D+NV P K +V +E +++ +R
Sbjct: 299 HPIDEVLGA-RQLHAQFCALHLQIDETRIDVNVHPTKNSVIFLEKEEIIEEIR 350
>Hs7657337 [L] KOG1977 DNA mismatch repair protein - MLH3 family
Length = 1429
Score = 94.7 bits (234), Expect = 6e-19
Identities = 91/392 (23%), Positives = 170/392 (43%), Gaps = 65/392 (16%)
Query: 13 KITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVGISEDDLDNVG 72
K+ SG I L ++EL NS+DA+A K + N ++ DNG G+ DD++ VG
Sbjct: 12 KLRSGLAISSLGQCVEELALNSIDAEA-KCVAVRVNMETFQVQVIDNGFGMGSDDVEKVG 70
Query: 73 QKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKG--PKAYKIVFNHS--- 127
++ TSK S +D+ +GFRGEA+A++ M + ++ K K + +F
Sbjct: 71 NRYFTSKCHSVQDLENPRFYGFRGEALANIADMASAVEISSKKNRTMKTFVKLFQSGKAL 130
Query: 128 GTCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAIIQTNVKIS 187
C + + GTTV V NLF LPVR+K + + +F + I++ +++ ++ S
Sbjct: 131 KACEADVTRASAGTTVTVYNLFYQLPVRRK--CMDPRLEFEKVRQRIEALSLMHPSISFS 188
Query: 188 VSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRHTSILPENQ 247
+ N + +++L D+ ++G + L I
Sbjct: 189 LRNDVSG---SMVLQLPKTKDVCSRFCQIYGLGKSQKLREISF----------------- 228
Query: 248 KEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDYPKVAKTIN---------- 297
EF+ ++G IS + +K+ Q++++NKR V K+ K I+
Sbjct: 229 ---KYKEFE--LSGYISSEA----HYNKNMQFLFVNKRLVLRTKLHKLIDFLLRKESIIC 279
Query: 298 -----ETYQSFNN--------VQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDA 344
T + N+ Y +V++ + D+ + P K + + +L
Sbjct: 280 KPKNGPTSRQMNSSLRHRSTPELYGIYVINVQCQFCEYDVCMEPAKTLIEFQNWDTLLFC 339
Query: 345 LRESLQLFFQKQGFVVPKS-----ETTSDNPF 371
++E +++F +++ V S E + DN F
Sbjct: 340 IQEGVKMFLKQEKLFVELSGEDIKEFSEDNGF 371
>At4g35520 [L] KOG1977 DNA mismatch repair protein - MLH3 family
Length = 1151
Score = 94.4 bits (233), Expect = 7e-19
Identities = 62/184 (33%), Positives = 102/184 (54%), Gaps = 5/184 (2%)
Query: 12 HKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVGISEDDLDNV 71
H + SG ++ D+ ++EL+ NSLDA A K+ I F S++ D+G G+S DDL +
Sbjct: 13 HSMRSGIIMFDMARVVEELVFNSLDAGATKVSI-FVGVVSCSVKVVDDGSGVSRDDLVLL 71
Query: 72 GQKHRTSKISSFEDVSKVT-SFGFRGEAIASLCQMGKVIITTTTKG-PKAYKIVFNHSGT 129
G+++ TSK F +V + +FGFRGEA+AS+ + + + T G P Y+ V S
Sbjct: 72 GERYATSKFHDFTNVETASETFGFRGEALASISDISLLEVRTKAIGRPNGYRKVMKGSKC 131
Query: 130 CNKIICS--RNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAIIQTNVKIS 187
+ I +++GTTV V +LF + PVR+K + K+ + A++ +NV S
Sbjct: 132 LHLGIDDDRKDSGTTVTVRDLFYSQPVRRKYMQSSPKKVLESIKKCVFRIALVHSNVSFS 191
Query: 188 VSNV 191
V ++
Sbjct: 192 VLDI 195
Score = 62.8 bits (151), Expect = 2e-09
Identities = 57/219 (26%), Positives = 101/219 (46%), Gaps = 25/219 (11%)
Query: 709 EHLLTLTVSKNDFQNMTIVGQFNLGFIIVTRCKEGAFDLFIVDQHASDEKYNFEMLQKNT 768
E L+ +++++ ++ ++ Q + +I + C A IVDQHA+DE+ E L+ T
Sbjct: 906 ESLVPESINRHSLEDAKVLQQVDKKYIPIVACGTVA----IVDQHAADERIRLEELR--T 959
Query: 769 VFKSQSLLSLKTLELSVIDEL---LVMEYKD------------VFSKNGFKLSIDQEEEP 813
F + +LL + L L V+ E+ L+ Y + V FK ++ +
Sbjct: 960 KFINDALL-IFVLTLKVLPEMGYQLLQSYSEQIRDWGWICNITVEGSTSFKKNMSIIQRK 1018
Query: 814 GQRIKLVSFPVSKNTMFTEYDFHELIQLIREHEGHDMSNIRCSKIRSMFAMRACRSSIMI 873
I L + P ++ D E +Q + + +G S I S +R + + +ACR +IM
Sbjct: 1019 PTPITLNAVPCILGVNLSDVDLLEFLQQLADTDGS--STIPPSVLRVLNS-KACRGAIMF 1075
Query: 874 GKPLSMRTMKKVVNNLSDLEKPWNCPHGRPTLRHLMELK 912
G L +++ L + C HGRPT L++LK
Sbjct: 1076 GDSLLPSECSLIIDGLKQTSLCFQCAHGRPTTVPLVDLK 1114
>Hs22046253 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 178
Score = 93.2 bits (230), Expect = 2e-18
Identities = 50/118 (42%), Positives = 72/118 (60%), Gaps = 2/118 (1%)
Query: 51 IESIECADNGVGISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVII 110
++ IE + NG G+ E++ + KH TSKI F D+++V +FGFRGEA++SLC + V I
Sbjct: 1 MDLIEVSGNGCGVEEENFKGLTLKHHTSKIQEFADLTRVETFGFRGEALSSLCALSDVTI 60
Query: 111 TTTTKGPK-AYKIVFNHSG-TCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQ 166
+T K ++VF+H G K GTTV V LF TLPVR K+F +N K++
Sbjct: 61 STCHVSAKVGTRLVFDHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKEFQRNIKKK 118
>YLR035c [R] KOG0017 FOG: Transposon-encoded proteins with TYA reverse
transcriptase integrase domains in various combinations
Length = 695
Score = 92.4 bits (228), Expect = 3e-18
Identities = 145/694 (20%), Positives = 293/694 (41%), Gaps = 66/694 (9%)
Query: 13 KITSGQVIVDLRSAIKELLENSLDAKADK--IEIIFKNYGIESIECADNGVGISEDDLDN 70
KI S I +A++ELL+NS+D+ A K I++ G E I D+G G+ D +
Sbjct: 13 KIVSSSFIYGPVAAVRELLDNSIDSGAKKVFIDVDSTTGGCEYISVKDDGSGVDIIDRPS 72
Query: 71 VGQKHRTSKISSFEDVSKVTSFGFRGEA---IASLC-QMGKVIITTTTKGPKAYK--IVF 124
+ ++ TSK+SS D+S +T+ GFRGEA +++LC Q G + + T T + +V
Sbjct: 73 MCLEYTTSKMSSLGDISILTTLGFRGEALFLLSNLCNQKGSMQVETKTADDVIGEKWLVD 132
Query: 125 NHSGTCN----KIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAII 180
+ G N K+ C GTTV++ L L R + ++ F+ I LI Y++I
Sbjct: 133 SKGGITNGKRYKVSCP--VGTTVILRKLLGGLRARYLEISSRPRKTFDELIYLINHYSLI 190
Query: 181 QTNVKISVSNVLPSGKKTLILSSIGKSDITRNL-VSVFGSNAGKGLASIDVDLDLSNIRH 239
N++ S L S +K +I + + L + + + LA + + L+ I
Sbjct: 191 HRNIRFYFS--LVSLQKN---GAIERKQMQETLDPKISRARSLSLLARLKKPVPLNFIVE 245
Query: 240 TSILPENQKEENASEFQVKITGQISMVSFGCGRASKDRQYVYINKRPVDY-----PKVAK 294
+ + + ++ N ++ + +++ + +++ +N+R + ++K
Sbjct: 246 ENFVID--EKINLDLILPRMVPESDVINI-----KRRFKFLSVNERALSLNLETGKTISK 298
Query: 295 TINETYQSFNNVQYPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQLFFQ 354
++ Y+ F+ + + ++ TK LD+N+ P+K V + E + + L+L +
Sbjct: 299 LLSSIYRDFSLLDPMVWFINLNCDTKLLDVNIEPEKNDVMIKSFEVIFKKIENKLKLLLE 358
Query: 355 KQ-----GFVVPKSETTSDNPFGPKRIKVEPLDA--------STLHNSENSKIISNGNHL 401
++ + K S N + + DA + + + I + L
Sbjct: 359 ERIGIETNMLGDKHVQPSINEKTSPALVIPTPDAENEISKGCGAVSGKDKTDIPQKNSDL 418
Query: 402 RHPTIIKDEVHELPRLISPLRSPT-LAKMKGESEQSELKSSTVETEDLDDGFDDKLHNHR 460
PT + E +++ SPT ++ K EQ++L S+ + + N R
Sbjct: 419 IVPTFYDEANLENTTIVAATPSPTKFSEDKALDEQTQLTISSYRSSSSGSMASEDSTNWR 478
Query: 461 ESVHKDEISANNHLDYVAEDVNTGPHLLNPHE--KEGDTKRLFVDSDLENTIESESNVIS 518
+ + E+S N+ + N E E + L D+ + N +I+
Sbjct: 479 HN-FQQELSENSEVAGAGSSTLPSSLTYNYIETIPENEDLELSKDASISNPF-----MIT 532
Query: 519 KELDESEDVDIDKNNLKVTPKGNHIQLGDFLHRRMSNVDIEKSPVEVDELVVQIDNNIS- 577
K + ++ + + K T G+ + G R++SN + +K +++ + + +N +
Sbjct: 533 KIRNVNKKLSENLLEAKRTSCGDANKRGMPNERQLSNTE-KKELIKLQQTYGKRNNTVDM 591
Query: 578 TIPASQDRDNKLVFHPHTSHSGNDSCRHSHNHSPNESDYSDDDFENGTDIVFKNTVENES 637
TIP + + ++ SC H P +S ++ N KN +
Sbjct: 592 TIPRNSKK------KVTDNYIKKASCMHKTR--PKLMHFS--EYTNNYVYTLKNEKIVKH 641
Query: 638 DLEQIKKQIEGSSSESLSLHQINNLVTSVRASLK 671
D + K+ S + ++L+ ++RA +K
Sbjct: 642 DSDNFAKETLWLRSRDDATSPSSSLLQALRAHVK 675
>ECU05g0300 [L] KOG1979 DNA mismatch repair protein - MLH1 family
Length = 563
Score = 86.3 bits (212), Expect = 2e-16
Identities = 84/349 (24%), Positives = 160/349 (45%), Gaps = 30/349 (8%)
Query: 1 MGIQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNG 60
M I+ + + I +I++G+VI + +KE +ENSLDA + I I + G+ ++ D+G
Sbjct: 1 MEIKRLPSDVISRISAGEVITRPYNILKETIENSLDANSTHITIKMEQDGL-TLTVEDDG 59
Query: 61 VGISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTK-GPKA 119
GI E D + + +++ TSK++ E++ ++S+GFRGEA++S+ + ++ + + + G
Sbjct: 60 DGIHESDFELLCKQYCTSKLTKEEELFSLSSYGFRGEALSSISRCARIKVRSKRREGEIG 119
Query: 120 YKIVFNHSGTCNKIICSRNTGTTVLVSNLFDTLPVRKKDFIKNYKRQFNRSIDLIQSYAI 179
Y+ V+ + GT V + N+F VR+K F K + + + L+ Y++
Sbjct: 120 YEAVYRDTEMITIKGVGMKDGTIVEIKNIFYNNKVREKHFSKK-REEIREMMWLVGMYSV 178
Query: 180 IQTNVKISVSNVLPSGKKTLILSSIGKSDITRNLVSVFGSNAGKGLASIDVDLDLSNIRH 239
+ + L G+K L + KS + + K R
Sbjct: 179 FNSRISFE----LFYGEK---LQELPKSRVCVGEDGYSNEDRVK--------------RK 217
Query: 240 TSILPENQKEENASEFQVKITGQISMVSFGCGR--ASKDRQYVYINKRPVDYPKVAKTIN 297
+L E K + F ++ + +V F + K +++N R V ++ +++
Sbjct: 218 VGMLNELYKADGKLLF---VSDKEYLVIFSTQQFCLRKGMLVLFVNGRLVVSQEMKESLF 274
Query: 298 ETYQSFNNVQ-YPSFVLDFRVGTKFLDLNVTPDKRTVSLHYEEYVLDAL 345
+ Y+ Q P L+ V +D+NV P KR V EE + L
Sbjct: 275 KVYKDILPPQKQPLIYLELYVEKSMVDVNVHPSKREVLFSNEESMTQRL 323
>YPL164c [L] KOG1977 DNA mismatch repair protein - MLH3 family
Length = 715
Score = 82.8 bits (203), Expect = 2e-15
Identities = 87/410 (21%), Positives = 173/410 (41%), Gaps = 75/410 (18%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ +++ ++ S V L SA++E+++NS+DA A I+++ + S D+G+G
Sbjct: 5 IRKLDSDVSERLKSQACTVSLASAVREIVQNSVDAHATTIDVMIDLPNL-SFAVYDDGIG 63
Query: 63 ISEDDLDNVGQKHRTSKISSFEDVSKVTSFGFRGEAIASLCQMGKVIITTTTKGPKAYKI 122
++ DL+ + ++ TSKI D+ + ++G+RG+A+ S+ + + + + K Y
Sbjct: 64 LTRSDLNILATQNYTSKIRKMNDLVTMKTYGYRGDALYSISNVSNLFVCSKKKD---YNS 120
Query: 123 VFNHSGTCNKIICSRNT------------------GTTVLVSNLFDTLPVRKKDF----- 159
+ ++ S NT GT V+V ++ LPVR++
Sbjct: 121 AWMRKFPSKSVMLSENTILPIDPFWKICPWSRTKSGTVVIVEDMLYNLPVRRRILKEEPP 180
Query: 160 IKNYKRQFNRSIDLIQSYAIIQTNV----KISVSNVLPSGKKTLILSSIGKSDITRNLVS 215
K + + ++ + +I NV K+ ++ + K + +++ L +
Sbjct: 181 FKTFNTIKADMLQILVMHPMISLNVQYTDKLRINTEVLFRSKNITEGLTKHQQMSQVLRN 240
Query: 216 VFGSNAGKGLASIDVDLDLSNIRHTSILPENQKEENASEF-QVKITGQISMVSFGCGRAS 274
VFG +I+P + ++ + +F + +I G IS + G
Sbjct: 241 VFG----------------------AIIPPDMLKKVSLKFNEYQIEGIISKMPVGL---- 274
Query: 275 KDRQYVYINKRP---------VDYPKVAKTINETYQSFNNVQ--------YPSFVLDFRV 317
KD Q++YIN R VD A+ E S + +P F+LD R
Sbjct: 275 KDLQFIYINGRRYADSAFQGYVDSLFQAQDFGEKGMSLLKTKSVGKPYRSHPVFILDVRC 334
Query: 318 GTKFLDLNVTPDKRTVSLHYEEYVLDALRESLQLFFQKQGFVVPKSETTS 367
DL P K+ V + + + ++++ F QG++ P +S
Sbjct: 335 PQTIDDLLQDPAKKIVKPSHIRTIEPLIVKTIRSFLTFQGYLTPDKSDSS 384
>Hs4885553 [L] KOG1978 DNA mismatch repair protein - MLH2/PMS1/Pms2 family
Length = 264
Score = 70.1 bits (170), Expect = 1e-11
Identities = 30/69 (43%), Positives = 50/69 (71%)
Query: 3 IQAIENADIHKITSGQVIVDLRSAIKELLENSLDAKADKIEIIFKNYGIESIECADNGVG 62
I+ I+ +H+I SG V++ L +A+KEL+ENSLDA A I++ K+YG++ IE +DNG G
Sbjct: 186 IKPIDRKSVHQICSGPVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCG 245
Query: 63 ISEDDLDNV 71
+ E++ + +
Sbjct: 246 VEEENFEGL 254
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.133 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,030,574
Number of Sequences: 60738
Number of extensions: 2499808
Number of successful extensions: 7485
Number of sequences better than 1.0e-05: 23
Number of HSP's better than 0.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 7393
Number of HSP's gapped (non-prelim): 41
length of query: 923
length of database: 30,389,216
effective HSP length: 116
effective length of query: 807
effective length of database: 23,343,608
effective search space: 18838291656
effective search space used: 18838291656
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)