ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2790 good TU KOG0998 Intracellular trafficking, secretion, and vesicular transport Synaptic vesicle protein EHS-1 and related EH domain proteins
r_klactIII2790 good TU KOG0998 Signal transduction mechanisms Synaptic vesicle protein EHS-1 and related EH domain proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2790 984117 985256 380
(380 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL084c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related ... 313 2e-85
SPBC11G11.02c [TU] KOG0998 Synaptic vesicle protein EHS-1 and re... 174 3e-43
Hs10864047 [TU] KOG0998 Synaptic vesicle protein EHS-1 and relat... 91 4e-18
Hs4503593 [TU] KOG0998 Synaptic vesicle protein EHS-1 and relate... 83 8e-16
CE02903 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related ... 50 7e-06
7291848 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related ... 49 9e-06
>YNL084c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 349
Score = 313 bits (803), Expect = 2e-85
Identities = 169/377 (44%), Positives = 230/377 (60%), Gaps = 30/377 (7%)
Query: 1 MPKLEQFEIKKYWQIFSGLKPVENKLTHDQVLPILFNSKLDTSILNKIWFLAXXXXXXXX 60
MPKLEQFEIKKYWQIFSGLKP+ENK+ HDQVLPIL+NSKLD+S+LNKIWFLA
Sbjct: 1 MPKLEQFEIKKYWQIFSGLKPIENKVNHDQVLPILYNSKLDSSVLNKIWFLADIDDDDNL 60
Query: 61 XFEEFVICMRMIFDMVNKNIDSVPDELPDWLIPGSKAELVKQRKTERSSGTAEXXXXXXX 120
FEEFVICMR+IFDMVNKNI SVPDELPDWLIPGSK L+K+RK + A+
Sbjct: 61 DFEEFVICMRLIFDMVNKNISSVPDELPDWLIPGSKVNLIKERKKRKQIENAD------- 113
Query: 121 XXXXXXXDDYQKEVDWYISRDDKSQYESIYESAITSRDNSVSYVSLSSAVRSKYINLSSQ 180
+ +VDWY+S DD +QYE IY S D ++++ LS+ + +K+ N+S
Sbjct: 114 -----LPPKKEIKVDWYMSPDDLNQYEKIYNSCAKLTDGTITFNELSTKLSTKFFNISKT 168
Query: 181 DLEKTWRLVNPKLDTSIDKDPALYFIHILRQVNDYACPIPSHLPSALKETFTKTRVSTDL 240
DL K W L+NP+ SID+DP YFIH LRQ ND IP+ LP++L E K ++S DL
Sbjct: 169 DLNKVWSLINPQNLPSIDRDPTFYFIHCLRQRNDLGAEIPASLPNSLAEVCNKKQLSYDL 228
Query: 241 SSKQSEVRRPTLSTSNSSSYQIPKRGGTDFSVTQGTDWEVVRLQRELANIDSELSSAQQQ 300
S Q +R + + + +D S +N+ S S +Q+
Sbjct: 229 RSSQPPTKRKEEANEVDNLRDNGQNSSSDSSG---------------SNVLSNEDSIKQK 273
Query: 301 STSHNDSNDRMKLVKQQLEQFLEYQKN-LVNNSNTSSESVDVGGLRDDIESIEQQVQMLE 359
S D D++ +++QLE L Y+K+ + S+ +++ + DD+++IEQQV++LE
Sbjct: 274 YASLTD--DQVANMREQLEGLLNYKKSEKTQGGSKLSKRINIRSITDDLDNIEQQVEVLE 331
Query: 360 EYLKTKKSELHNLKIEV 376
YL K+ EL L+ E+
Sbjct: 332 NYLNNKRHELQALQAEI 348
>SPBC11G11.02c [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 375
Score = 174 bits (440), Expect = 3e-43
Identities = 109/376 (28%), Positives = 191/376 (49%), Gaps = 10/376 (2%)
Query: 8 EIKKYWQIFSGLKPVENKLTHDQVLPILFNSKLDTSILNKIWFLAXXXXXXXXXFEEFVI 67
E KYW+IF GL P L+ + +L +SKL + L KIW LA F+EF I
Sbjct: 5 EKNKYWEIFRGLNPENGYLSGSKAAGVLRSSKLSSDKLEKIWDLADIDDDGMFDFDEFAI 64
Query: 68 CMRMIFDMVNKNIDSVPDELPDWLIPGSKAELVKQRKTERSSGTAEXXXXXXXXXXXXXX 127
M++ FD++N +VPD +P+ L+ SK LV R R +
Sbjct: 65 AMKITFDLINGVYKTVPDRVPEALVSTSKKHLVAARDALRGNDDIALLHKVPSLDTDPED 124
Query: 128 DDYQKEVDWYISRDDKSQYESIYESAITSRDNSVSYVSLSSAVRSKYINLSSQDLEKTWR 187
+ DWYIS DK +Y IY S ++ VS+ L+ + + ++K W+
Sbjct: 125 AVLKDGFDWYISPSDKIRYSDIY-SLHCNKHGEVSFNGLAPVFTP--FGVPNSQIQKAWK 181
Query: 188 LVNPKLDTSIDKDPALYFIHILRQVNDYACPIPSHLPSALKETFTKTRVSTDLSSKQSE- 246
LVNP+ +I KD L F+HIL Q ++ IP+ +P +LK +F + + +L S S
Sbjct: 182 LVNPQGTETIQKDQCLVFLHILTQRSN-GFRIPNDVPYSLKASFKRGNIDYNLDSYNSTN 240
Query: 247 --VRRPTLSTSNSSSYQIPKRGGTDFSVTQGTDWEVVRLQRELANIDSELSSAQQQSTSH 304
PT++ S + PK + +DWE++ L+ EL+ +D ++ S Q+++
Sbjct: 241 NYYSSPTMAPSTGGAK--PKSDLDAPRDVRDSDWELISLRNELSKLDEKILSLQRETDDV 298
Query: 305 NDSNDRMKLVKQQLEQFLEYQKNLVNN-SNTSSESVDVGGLRDDIESIEQQVQMLEEYLK 363
N + ++ KL+++ L++ L+Y+ ++ + N + +D++ +EQQ+ +L +L+
Sbjct: 299 NIAQNKSKLIQRDLQKVLDYKLGILQSLKNDGPNGPSASAIDNDLKMLEQQLNVLGRHLE 358
Query: 364 TKKSELHNLKIEVQSL 379
+KS++ L+ ++SL
Sbjct: 359 GRKSQVAKLEERLRSL 374
>Hs10864047 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 864
Score = 90.5 bits (223), Expect = 4e-18
Identities = 92/406 (22%), Positives = 161/406 (38%), Gaps = 51/406 (12%)
Query: 8 EIKKYWQIFSGLKPVENKLTHDQVLPILFNSKLDTSILNKIWFLAXXXXXXXXXFEEFVI 67
E K+ IF L P+ L+ D+V P+L NSKL +L ++W L+ +EF +
Sbjct: 127 EKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAV 186
Query: 68 CMRMIFDMVNKNIDSVPDELPDWLIPGSKAELV----------------KQRKTERSSGT 111
M +++ + K + VP LP LIP SK + ++ S G+
Sbjct: 187 AMHLVYRALEK--EPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGS 244
Query: 112 AEXXXXXXXXXXXXXXDDYQKEVDWYISRDDKSQYESIYESAITSRDNSVSYVSLSSAVR 171
Q V+W + DK +++ I+ D VS +
Sbjct: 245 VSSLNSTGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIF- 303
Query: 172 SKYINLSSQDLEKTWRLVNPKLDTSIDKDP---ALYFIH--ILRQVNDYACPIPSHLPSA 226
+ L+ L W L + + + KD A+YFI + + ++ P +P +
Sbjct: 304 -MHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPS 362
Query: 227 LKET-------------FTKTRVSTDLSSKQSEVRRPTLSTSNSSSYQIPKRGGTDFSVT 273
+ T FT + D+S + ++++R S + + ++
Sbjct: 363 ERGTPGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREK-------EEAIR 415
Query: 274 QGTDWEVVRLQRELANIDSELSSAQQQSTSHNDSNDRMKLVKQQLEQFLEYQKNLVNNSN 333
Q T EV LQ +L D E SS Q+ D+ DR+ + QQ + + ++
Sbjct: 416 QKTS-EVQELQNDL---DRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDV--RQK 469
Query: 334 TSSESVDVGGLRDDIESIEQQVQMLEEYLKTKKSELHNLKIEVQSL 379
E+ + L+ I+S E ++ E+ L KSEL+ L+ E L
Sbjct: 470 CQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQL 515
>Hs4503593 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 896
Score = 82.8 bits (203), Expect = 8e-16
Identities = 91/384 (23%), Positives = 152/384 (38%), Gaps = 65/384 (16%)
Query: 11 KYWQIFSGLKPVENKLTHDQVLPILFNSKLDTSILNKIWFLAXXXXXXXXXFEEFVICMR 70
KY IF L PV L+ D+V P+L NSKL IL ++W L+ +EF + M
Sbjct: 131 KYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMF 190
Query: 71 MIFDMVNKNIDSVPDELPDWLIPGSKAELVKQRKTERSSGTAEXXXXXXXXXXXXXXDDY 130
+++ + K + VP LP L+P SK RKT
Sbjct: 191 LVYCALEK--EPVPMSLPPALVPPSK------RKT------------------------- 217
Query: 131 QKEVDWYISRDDKSQYESIYESAITSRDNSVSYVSLSSAVRSKYI--NLSSQDLEKTWRL 188
W +S +K++Y+ I+ D VS + VR ++ L S L W L
Sbjct: 218 -----WVVSPAEKAKYDEIFLKTDKDMDGFVSGLE----VREIFLKTGLPSTLLAHIWSL 268
Query: 189 VNPKLDTSIDKDPALYFIHILRQ-----VNDYACPIPSHLPSALKETFTKTRVSTDLSSK 243
+ K + KD H++ Q ++ P +P + + + K + + +
Sbjct: 269 CDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVAD 328
Query: 244 QSEVRRPTLSTSNSSSYQIPKRGGT--------DFSVTQGTDWEVVRLQRELANIDSELS 295
S ++ L T N+ + + + ++ Q T EV LQ E+ ++ L
Sbjct: 329 FSAIKE--LDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTS-EVQDLQDEVQRENTNLQ 385
Query: 296 SAQQQSTSHNDSNDRMKLVKQQLEQFLEYQKNLVNNSNTSSESVDVGGLRDDIESIEQQV 355
Q Q + D + K QLE+ L+ + + E+ + L+ ++ S E Q+
Sbjct: 386 KLQAQKQQVQELLDELDEQKAQLEEQLKEVR-----KKCAEEAQLISSLKAELTSQESQI 440
Query: 356 QMLEEYLKTKKSELHNLKIEVQSL 379
EE L + EL L+ E L
Sbjct: 441 STYEEELAKAREELSRLQQETAEL 464
>CE02903 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 751
Score = 49.7 bits (117), Expect = 7e-06
Identities = 31/87 (35%), Positives = 42/87 (47%), Gaps = 2/87 (2%)
Query: 11 KYWQIFSGLKPVENKLTHDQVLPILFNSKLDTSILNKIWFLAXXXXXXXXXFEEFVICMR 70
KY IF L PV KL+ V P+L NS LD L +IW L+ E + +
Sbjct: 120 KYDSIFQSLNPVNGKLSGAHVRPVLMNSGLDAHALARIWELSDQDKDGNLDRIEMSVALH 179
Query: 71 MIFDMVNKNIDSVPDELPDWLIPGSKA 97
+++ + D VP +LP LI SKA
Sbjct: 180 LVYRSLQS--DPVPAQLPPNLIHPSKA 204
>7291848 [TU] KOG0998 Synaptic vesicle protein EHS-1 and related EH domain
proteins
Length = 668
Score = 49.3 bits (116), Expect = 9e-06
Identities = 27/78 (34%), Positives = 39/78 (49%), Gaps = 2/78 (2%)
Query: 11 KYWQIFSGLKPVENKLTHDQVLPILFNSKLDTSILNKIWFLAXXXXXXXXXFEEFVICMR 70
KY Q+F L P L ++V +L +SKL SIL IW LA EFV+ M
Sbjct: 136 KYEQLFESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMH 195
Query: 71 MIFDMVNKNIDSVPDELP 88
+++ + K ++P LP
Sbjct: 196 LVYQTLQKR--TIPSVLP 211
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.312 0.129 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,161,823
Number of Sequences: 60738
Number of extensions: 770724
Number of successful extensions: 3183
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3161
Number of HSP's gapped (non-prelim): 18
length of query: 380
length of database: 30,389,216
effective HSP length: 108
effective length of query: 272
effective length of database: 23,829,512
effective search space: 6481627264
effective search space used: 6481627264
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)