ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2846 good D KOG2464 Cell cycle control, cell division, chromosome partitioning Serine/threonine kinase (haspin family)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2846 1001553 999469 -695
(695 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGL021w [D] KOG2464 Serine/threonine kinase (haspin family) 194 5e-49
YBL009w [D] KOG2464 Serine/threonine kinase (haspin family) 164 4e-40
ECU03g0890 [D] KOG2464 Serine/threonine kinase (haspin family) 63 1e-09
CE07824_2 [D] KOG2464 Serine/threonine kinase (haspin family) 55 5e-07
At1g09450 [D] KOG2464 Serine/threonine kinase (haspin family) 54 6e-07
Hs13994374 [D] KOG2464 Serine/threonine kinase (haspin family) 54 1e-06
>YGL021w [D] KOG2464 Serine/threonine kinase (haspin family)
Length = 760
Score = 194 bits (492), Expect = 5e-49
Identities = 193/725 (26%), Positives = 300/725 (40%), Gaps = 140/725 (19%)
Query: 8 MDFETSFDEYSIGESAKRFIALEVSDHEDDYNSSVDSFHESNIGFVADVDTERVSQSAAV 67
MDFETSF+E+ KRFIALEVSD++DD ++ + + DT +S+A+
Sbjct: 26 MDFETSFEEFV---EDKRFIALEVSDNDDDCDTDLTA------------DTADELESSAI 70
Query: 68 APTLEH---ASITTGQEETGKGDSVSVASTSGIEPPLATSNGNSAGNIRPHKDEKKRWSF 124
E ++TTG + K TSN KKRWS
Sbjct: 71 LKMRESDASLNVTTGNNTSRK----------------TTSNS------------KKRWSL 102
Query: 125 ISTNSS-----SKKRWSTLSFVSDTKSNKXXXXX--------XXXXXXXXXXXXXXXXXX 171
+S +S+ SKKRWS LS ++S+K
Sbjct: 103 LSNHSAVSSSKSKKRWSVLSSSFTSESHKDRESRNVLQQKRKSLQSYSSLDTVASNSSIS 162
Query: 172 XXNKLKRSSTGASLRSMFNKIALKDEDKENSGVMLAHKRGQSTTLASSFTVSAKAQPTPS 231
+ LKRSSTG SLR +F KI + D+ + + K T+ + A
Sbjct: 163 ASSSLKRSSTGLSLRQLFTKIGINDDISQPGIGIPQGKENLPPTMGKKNSSIASTSSENR 222
Query: 232 ARIPLKPINQNNKRE----QRFSTIPMSPXXXXXXXXXXXXXXXXGTRWKFWKR-KQDCP 286
R PLKP+ ++KR Q+ + + ++W+FWKR K P
Sbjct: 223 LRTPLKPLVNHSKRPTSQPQQQQPLYNASLSSRRSSISSTVSSSSSSKWRFWKRNKNQTP 282
Query: 287 ------------------QDSRFMQDSNISMRNKSSLSDLRKSIFQNSMMGQSEPT---- 324
+DS + +++K+S SD K+IF ++ +S T
Sbjct: 283 ALLQPDHHSLKTFPAVNRRDSMTPVEPRNMVKHKTSFSDFHKTIFSSNTYSESSDTISSM 342
Query: 325 ----QDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRRN-----------SSIASND 369
++ +RN ++ +SND
Sbjct: 343 EITLKNKASSSSLSLNVLKKRNSQSSLKHKSSHASLQKFKRNKGKSSMIAPSTATNSSND 402
Query: 370 SSAP----------QISLPIPDQVSRDKIRTKLRHXXXXXXXXXXXXXXXXXXAETDEYD 419
S +ISLP+PDQVSRDKI+ KLR+ +++D
Sbjct: 403 DSCSYSSKNSTLSHRISLPVPDQVSRDKIQNKLRYSTSLLSLNSKSSLPM----NKNDHD 458
Query: 420 ESVLQQMLDLCTVKEILPFTNS---PHLRQLDHY--IYIDSNDYTIYKI----VPLDNDD 470
E++L+Q+L C +K IL P + ++H I + SN + I ++ V L D
Sbjct: 459 ETLLRQILLNCDIKRILNPAKGDVLPLINDVNHLSSIQLTSNVWQIGEVICKKVSLGTID 518
Query: 471 RECKMTRQMRLQELQLTMLMNGTPGFVNVLDVKIIRREDDQTLFLVYHMKNHGKSLNQLI 530
+ + LQEL+ +M + L + +E + L+L K+HG ++ LI
Sbjct: 519 DITWDRKFLSLQELEKLKIMQQKFDGIPQLLKSFVVKEANGGLYLYLLFKDHGTPIS-LI 577
Query: 531 SNEHRKFSVTEIKDIITQCIRILYVAETKFQFEHRLLTLDHVLIDSSKNITLVDYKLSRV 590
S ++ K +I I C I++ E +FEHR LTLD++LID + NIT++D+K SR+
Sbjct: 578 SLKNWK----QILKIFWSCAGIIHGLEKNLKFEHRNLTLDNILIDGNGNITIIDFKCSRL 633
Query: 591 KY-GSQVLFTRLDHPLFFEFRKDYNTVLQW-------LRQSMTV---DSWPLFHPKTNLV 639
+ VL+ RLDHPLFF KD + + ++ + QSM + F P TNL
Sbjct: 634 QTPQDDVLYLRLDHPLFFLNGKDKSKINEYQYQFEFEIYQSMRILLNMDASAFEPMTNLY 693
Query: 640 WVNYV 644
W+ Y+
Sbjct: 694 WLYYL 698
>YBL009w [D] KOG2464 Serine/threonine kinase (haspin family)
Length = 676
Score = 164 bits (415), Expect = 4e-40
Identities = 163/592 (27%), Positives = 241/592 (40%), Gaps = 87/592 (14%)
Query: 177 KRSSTGASLRSMFNKIALKD----EDKEN-SGVMLAHKRGQSTTLASSFTVSAKAQPTPS 231
KRSSTG+SL+ +FNKI + D +KEN S +L+ + S + S K +
Sbjct: 90 KRSSTGSSLKQLFNKININDTAHSSNKENVSQSVLSENKLLSPSKRLSKQGLTKVTNS-K 148
Query: 232 ARIPLKPINQNNK----------REQRFST-----------IPMSPXXXXXXXXXXXXXX 270
R PL+PI+ + R +F +
Sbjct: 149 FRTPLRPISNQSTLSRDEPVKDFRSLKFRSGSDFKCWGDEKTSSHVHSSSVNSVNSFTST 208
Query: 271 XXGTRWKFWKR----------KQDCPQDSRFMQDSNI-SMRNKSSLSDLRKSIFQNSMMG 319
++WKFWK + QD F+Q S++ KSS+S SIF
Sbjct: 209 TSSSKWKFWKNDNLLSRSLSSRSVNDQDPNFVQPKPTNSLQKKSSISSFHNSIFGGGKHT 268
Query: 320 QSE-------PTQDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRRNSSIASND--- 369
+ + P RR + +
Sbjct: 269 EKKRNSGFIMPDHQSTKELNHKHSSSNLSFRSLKHKTSHSSLNKLKVRRKGNTQELNHPI 328
Query: 370 SSAPQISLPIPDQVSRDKIRTKLRHXXXXXXXXXXXXXXXXXXAETDEYDESVLQQMLDL 429
QISLP+PDQVS+DKI+ KL++ T +Y++S+LQQ+L L
Sbjct: 329 KKTCQISLPVPDQVSKDKIQLKLKNSTSLASLSSEVTPI-----NTLDYNDSILQQILQL 383
Query: 430 CTVKEILP----------FTNSPHLRQLDHYIY----IDSNDYTIYKIVPLDNDDRECKM 475
C VK IL FT + QL H + D I K V L +
Sbjct: 384 CDVKYILHDLREAQSLGLFTLNTRSVQLSHNFWQTYHSDMQTSLICKKVCLGALS-DLTT 442
Query: 476 TRQMRLQELQLTMLMNGTPGFVNVLDVKII---RREDDQTLFLVYHMKNHGKSLNQLISN 532
+ + L EL+ L+ GT G N+L ++ + E+DQ L L K G L++ +
Sbjct: 443 SNLISLHELKSLRLIQGTSGVANLLQAYVVPSNQCENDQNLILYLFFKYQGTPLSRCSNI 502
Query: 533 EHRKFSVTEIKDIITQCIRILYVAETKFQFEHRLLTLDHVLIDSSKNITLVDYKLSRVKY 592
++ ++ I QC ILYVAE+KFQ EHR LTLDH+LIDS N+TL+D K R
Sbjct: 503 DY-----SQALSIFWQCSSILYVAESKFQLEHRNLTLDHILIDSKGNVTLIDMKCCRFLN 557
Query: 593 --GSQVLFTRLDHPLFFEFRKDYNTVLQWLRQSMTVD--SWPLFHPKTNLVWVNYVVTKL 648
++ +TRLDH FF+ R + L +SM SW F P+TNL+W+ ++ + L
Sbjct: 558 IDNNKASYTRLDHHYFFQGRGTLQFEIYELMRSMLPQPISWATFEPRTNLLWLYHLSSSL 617
Query: 649 QHNCKDPQTPSPLLNKIQSSLEST-------KSRKLWKRHDGQIESCADIVS 693
K L + +E T K K + + I +C D++S
Sbjct: 618 LKMAKKAVVSGALNREENILIELTHLLDPARKHSKTIFKKELVIRTCGDLLS 669
>ECU03g0890 [D] KOG2464 Serine/threonine kinase (haspin family)
Length = 454
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/216 (25%), Positives = 98/216 (44%), Gaps = 38/216 (17%)
Query: 460 IYKIVPLDNDDRECKMTRQMRLQELQLTMLMNGTPGFVNVLDVKIIR------------- 506
+YKIVPL + E ++ +R E + ++G G + DV ++
Sbjct: 204 VYKIVPLGDTPDETSLSSFLR--ESIIFRTISGEDGVCGLKDVFLVAGRYPEEYLKAWDD 261
Query: 507 ----------REDDQTLFLVYHMKNHGKSLNQLISNEHRKFS-VTEIKDIITQCIRILYV 555
+ D+ + V M++ G+SL + KF + E+ I +R+L
Sbjct: 262 YGEEENERPCKYRDEQEYGVIVMEDGGESLESI------KFQKIAEVDAFIRSAVRVLAN 315
Query: 556 AETKFQFEHRLLTLDHVLIDSSKNITLVDYKLSRVKYGSQVLFTRLDHPLFFEFRKDYNT 615
E K++FEHR L ++LI + I L+D+ LSR++ G V+F L+ + F D
Sbjct: 316 LEKKYEFEHRDLHWGNILIREGQ-INLIDFSLSRLRSGGAVIFNDLNSKQWL-FEGDEAV 373
Query: 616 VLQWL----RQSMTVDSWPLFHPKTNLVWVNYVVTK 647
+Q+ + + W F P +N++W+ Y+V K
Sbjct: 374 DIQFRVYRDMRKLCSGCWSRFVPASNVLWLRYLVEK 409
>CE07824_2 [D] KOG2464 Serine/threonine kinase (haspin family)
Length = 356
Score = 54.7 bits (130), Expect = 5e-07
Identities = 39/156 (25%), Positives = 69/156 (44%), Gaps = 26/156 (16%)
Query: 514 FLVYHMKNHGKSLNQLISNEHRKFSVTEIKDIITQCIRILYVAETKFQFEHRLLTLDHVL 573
F+++ N G +L + S E+ II Q + + AE +FEHR L L +VL
Sbjct: 149 FILFVSANGGIALEDFVLE-----SENELFSIIHQLVLSMNAAEAALEFEHRDLHLGNVL 203
Query: 574 IDSSK--------------------NITLVDYKLSRVKYGSQVLFTRLDH-PLFFEFRKD 612
ID + + ++D+ LSR+ G+ ++ L++ P FE + D
Sbjct: 204 IDRNGVKELYYTVHGQKVPLSTHGIKVNIIDFTLSRISKGATTVYWDLENDPAIFEGQDD 263
Query: 613 YNTVLQWLRQSMTVDSWPLFHPKTNLVWVNYVVTKL 648
+ + +W F +TNL+W+ Y+ +L
Sbjct: 264 PQFEVYREMRKNCKSNWKKFSRRTNLMWIVYIANRL 299
>At1g09450 [D] KOG2464 Serine/threonine kinase (haspin family)
Length = 570
Score = 54.3 bits (129), Expect = 6e-07
Identities = 54/248 (21%), Positives = 102/248 (40%), Gaps = 66/248 (26%)
Query: 459 TIYKIVPLDNDDR---ECKMTRQMRLQELQLTMLMNGT-----------PGFVNVLDVKI 504
++ KIVP+D D R E + L+E+ L+ +N P ++ D+K+
Sbjct: 278 SVCKIVPIDGDFRVNGEVQKRADELLEEVILSWTLNQLRECETTAQNLCPTYIKTQDIKL 337
Query: 505 IRREDDQTL-------------------------FLVYHMKNHGKSLNQLISNEHRKFSV 539
+ D L ++++ +++ GK L + +
Sbjct: 338 CQGPYDPILIKAWEEWDAKHGSENDHPDFPEKQCYVMFVLEHGGKDLESFVL-----LNF 392
Query: 540 TEIKDIITQCIRILYVAETKFQFEHRLLTLDHVLIDSSKN-------------------- 579
E + ++ Q L VAE F+FEHR L ++L+ + +
Sbjct: 393 DEARSLLVQATAGLAVAEAAFEFEHRDLHWGNILLSRNNSDTLPFILEGKQVCIKTFGVQ 452
Query: 580 ITLVDYKLSRVKYGSQVLFTRL--DHPLFFEFRKDYNTVLQWLRQSMTVDSWPLFHPKTN 637
I+++D+ LSR+ G ++LF L D LF + D + +++T D W +TN
Sbjct: 453 ISIIDFTLSRINTGEKILFLDLTSDPYLFKGPKGDKQSETYRKMKAVTEDYWEGSFARTN 512
Query: 638 LVWVNYVV 645
++W+ Y+V
Sbjct: 513 VLWLIYLV 520
>Hs13994374 [D] KOG2464 Serine/threonine kinase (haspin family)
Length = 798
Score = 53.5 bits (127), Expect = 1e-06
Identities = 44/163 (26%), Positives = 75/163 (45%), Gaps = 27/163 (16%)
Query: 508 EDDQTLFLVYHMKNHGKSLNQLISNEHRKFSVTEIKDIITQCIRILYVAETKFQFEHRLL 567
+DDQ LF+V + G L Q+ + + S+ K I+ Q L VAE +FEHR L
Sbjct: 595 KDDQ-LFIVLEFEFGGIDLEQMRT---KLSSLATAKSILHQLTASLAVAEASLRFEHRDL 650
Query: 568 TLDHVLIDSSK--------------------NITLVDYKLSRVKYGSQVLF--TRLDHPL 605
+VL+ + ++++DY LSR++ V+F +D L
Sbjct: 651 HWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDL 710
Query: 606 FFEFRKDYNTVLQWLRQSMTVDSWPLFHPKTNLVWVNYVVTKL 648
F DY + L + + W +HP +N++W++Y+ K+
Sbjct: 711 FTG-DGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKM 752
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,963,108
Number of Sequences: 60738
Number of extensions: 1322868
Number of successful extensions: 4517
Number of sequences better than 1.0e-05: 6
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 4487
Number of HSP's gapped (non-prelim): 10
length of query: 695
length of database: 30,389,216
effective HSP length: 113
effective length of query: 582
effective length of database: 23,525,822
effective search space: 13692028404
effective search space used: 13692028404
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)