ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2876 good U KOG2066 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein VPS41
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2876 1011298 1013886 863
(863 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR080w [U] KOG2066 Vacuolar assembly/sorting protein VPS41 655 0.0
SPAP27G11.05c [U] KOG2066 Vacuolar assembly/sorting protein VPS41 258 3e-68
Hs7657677 [U] KOG2066 Vacuolar assembly/sorting protein VPS41 241 3e-63
Hs18105061 [U] KOG2066 Vacuolar assembly/sorting protein VPS41 222 2e-57
At1g08190 [U] KOG2066 Vacuolar assembly/sorting protein VPS41 202 1e-51
7289410 [U] KOG2066 Vacuolar assembly/sorting protein VPS41 168 3e-41
CE29305_2 [U] KOG2066 Vacuolar assembly/sorting protein VPS41 97 8e-20
>YDR080w [U] KOG2066 Vacuolar assembly/sorting protein VPS41
Length = 992
Score = 655 bits (1689), Expect = 0.0
Identities = 348/879 (39%), Positives = 514/879 (57%), Gaps = 79/879 (8%)
Query: 62 EPPLLTFSRMTQIPKTFFQRDSISACLFSDSLFAFATHSGLLHLTRPDFTTIRTFKCHRS 121
EPPLL ++R++Q+PK FFQRDSIS+CLF D+ FAF THSG+LHLT F I+T KCHRS
Sbjct: 97 EPPLLKYTRISQLPKNFFQRDSISSCLFGDTFFAFGTHSGILHLTTCAFEPIKTIKCHRS 156
Query: 122 SILSVTTDGYYFATGSIDGTVVIGSIEDPQDISGFDFKRPIHAVILDKNYTSTKTFISGG 181
SIL + TDG YFATGSIDGTV+IGS++DPQ+I+ +DFKRPI++V L N+ +++ F+SGG
Sbjct: 157 SILCINTDGKYFATGSIDGTVIIGSMDDPQNITQYDFKRPINSVALHSNFQASRMFVSGG 216
Query: 182 MAGEVILTQRNWLGNRTDTILEKN--------------NGSIVGIYTIDDVVFWMNDTGI 227
MAG+V+L+QRNWLGNR D +L K G I+GIYT+ D++ WM+D GI
Sbjct: 217 MAGDVVLSQRNWLGNRIDIVLNKKKKKKTRKDDLSSDMKGPIMGIYTMGDLILWMDDDGI 276
Query: 228 TFYSTASKAKLLNIPFPPDEQN----RPDLYWPKVTFPETDRIIICWGSHIWQVKISILK 283
TF ++++LLNIPFP N RPDL+ P V F E+DR++I WGS+IW K+S K
Sbjct: 277 TFCDVPTRSQLLNIPFPSRIFNVQDVRPDLFRPHVHFLESDRVVIGWGSNIWLFKVSFTK 336
Query: 284 NPEX------------------XXXXXXXXXXXXXXXRGVPDRKVELEHHVRLNCLVAGA 325
+ RG PD+KVELE H ++ L+ G
Sbjct: 337 DSNSIKSGDSNSQSNNMSHFNPTTNIGSLLSSAASSFRGTPDKKVELECHFTVSMLITGL 396
Query: 326 AAFKDDQYLCLAI-----------------------RQSSSGKLDTPELKIIDILNGEEL 362
A+FKDDQ LCL ++ K + PELKI+D+ NG+E+
Sbjct: 397 ASFKDDQLLCLGFDIDIEEEATIDEDMKEGKNFSKRPENLLAKGNAPELKIVDLFNGDEI 456
Query: 363 HTYQVISKSFQNMSLNDYHLGVHIGDGKSEYYLLSSTDAIITKELSLVDRFNWYVDKKLY 422
+ +VI K+++ +S+NDYHLG HI EYYL+SS DAI +ELSL D F+W++++K Y
Sbjct: 457 YNDEVIMKNYEKLSINDYHLGKHIDKTTPEYYLISSNDAIRVQELSLKDHFDWFMERKQY 516
Query: 423 VKAWEIGNYAVSPMDRLVVGLKYIDLLFSENSWTDASGAIATIF----XXXXXXXXXLSN 478
KAW+IG Y + +R +GLK+++ L ++ W + IF ++
Sbjct: 517 YKAWKIGKYVIGSEERFSIGLKFLNSLVTKKDWGTLVDHLNIIFEETLNSLDSNSYDVTQ 576
Query: 479 FKISKWGMYILAFIKHDKTDEVVDTIPTSPVLDYNVYTTVLTWYLKKSRYTELLHLLSTW 538
+ +W I I E+ IP P L +VY VL ++L + ++ W
Sbjct: 577 NVLKEWADIIEILITSGNIVEIAPLIPKKPALRKSVYDDVLHYFLANDMINKFHEYITKW 636
Query: 539 SHFLYDTVLITDQIEDALQIKDTP-----------ILRRCLVVIYLASEQYLAAVRQQLI 587
L+ +++E ++ P R LV +YL +Y A+ L
Sbjct: 637 DLKLFSVEDFEEELETRIEAASEPTASSKEEGSNITYRTELVHLYLKENKYTKAIPHLLK 696
Query: 588 LRDAAALDVLLEHNLLSNFVSELKDIVLLPFEGPIDRLNIMKLSQIKNIFQKSIALLVDN 647
+D AL ++ NLL ++ ++ DI+LLP++G I ++ + + +I+ IF K I LL +N
Sbjct: 697 AKDLRALTIIKIQNLLPQYLDQIVDIILLPYKGEISHISKLSIFEIQTIFNKPIDLLFEN 756
Query: 648 RHSIPIEKLIE----ELSGSLQVLLFLFLQECMKI-EPLMMAPYEDNMLELYLIYDKPGL 702
RH+I + ++ E + S + +LF +L + + + M++PYE+ ++ELY YD+ L
Sbjct: 757 RHTISVARIYEIFEHDCPKSFKKILFCYLIKFLDTDDSFMISPYENQLIELYSEYDRQSL 816
Query: 703 LGFLKTKSNYNIDKAIKFCQEENNLHNELIFLWSKIGENRKALSLIIDRLDDPKLAFQFV 762
L FL+ +NYN++ AI+ C + L+NELI+LW KIGE +KALSLIID L +P+LA FV
Sbjct: 817 LPFLQKHNNYNVESAIEVCSSKLGLYNELIYLWGKIGETKKALSLIIDELKNPQLAIDFV 876
Query: 763 KDSLDNELWNFLINYSLDRPKFIKAILDSSELFEDEIATVVDKIPDNIEVEGLKKSLEDI 822
K+ D+ELW F+INYSLD+P F KAIL S+ + V+ + D+++++ L+ ++ I
Sbjct: 877 KNWGDSELWEFMINYSLDKPNFTKAILTCSDETSEIYLKVIRGMSDDLQIDNLQDIIKHI 936
Query: 823 ATNNELKLGVVSSIFKIVDDETKEMVAEFLIIRKKGKIF 861
N L L V +I I++DETK+ EFL IR +GK+F
Sbjct: 937 VQENSLSLEVRDNILVIINDETKKFANEFLKIRSQGKLF 975
>SPAP27G11.05c [U] KOG2066 Vacuolar assembly/sorting protein VPS41
Length = 886
Score = 258 bits (659), Expect = 3e-68
Identities = 203/812 (25%), Positives = 393/812 (48%), Gaps = 76/812 (9%)
Query: 62 EPPLLTFSRMTQIPKTFFQRDSISACLFSDSLFAFATHSGLLHLTRPDFTTIRTFKCHRS 121
E P L + R+T+ + F D+ISAC S F F +H+G +++ + + +R H +
Sbjct: 22 EEPKLIYERITEKFQGCFMNDTISACAISKEHFFFGSHNGAIYIYQKNGILLRKMILHSA 81
Query: 122 SI--LSVTTDGYYFATGSIDGTVVIGSIEDPQDISGFDFKRPIHAVILDKNYT--STKTF 177
S+ LSV + A+ S+DG ++I +I ++ + DFKRP+ +V +D Y+ S++
Sbjct: 82 SVVDLSVDLESENLASCSMDGKMIISNITT-RETTVHDFKRPLLSVAIDPYYSTRSSRQV 140
Query: 178 ISGGMAGEVILTQRNWLGNRTDTILEKNNGSIVGIYTIDDVVFWMNDTGITFYSTASKAK 237
+SGG AG+V+L+++ WLGN+ DT+L+ + G++ I + W +D GIT YST K
Sbjct: 141 LSGGRAGKVVLSEKGWLGNK-DTVLQADCGAVYKISWYTTYIAWASDLGITVYSTEF-GK 198
Query: 238 LLNIPFPPDEQNRPDLYWPKVTFPETDRIIICWGSHIWQVKISILKNPEXXXXXXXXXXX 297
+L PP +++ ++ + R++I W I V I
Sbjct: 199 VLGRLEPPKRLPNDEIFPYQLFWQSESRLVIGWSDQIMIVSIQ----------------- 241
Query: 298 XXXXXRGVPDRKVELEHHVRLNCLVAGAA--AFKDDQYLCLAIRQSSSGKLDT------- 348
+P K+ L+ + ++ +V+G F +A + + + +
Sbjct: 242 RSNVANELP--KISLQALLEIDSIVSGVLMLGFNILTLAYIANVEDFTSAIPSQRIEGCR 299
Query: 349 PELKIIDILNGEELHTYQVISKSFQNMSLNDYHLGVHIGDGKSEYYLLSSTDAIITKELS 408
PEL++ID + +EL + ++ + +DYHL + S +++S D + +E +
Sbjct: 300 PELRLIDS-SFKELCGDAIGLANYSRLQPSDYHL-LPDPSSNSHSFVISPNDIVYVRERN 357
Query: 409 LVDRFNWYVDKKLYVKAWEIGNYAVSPMDRLVVGL-------KYIDLLFSENSWTDASGA 461
+D + V K++Y +A + AV + + L KYI L + + +A
Sbjct: 358 QIDHVKYLVSKEMYAEAID----AVKKLPEIPPSLQISELAKKYIFHLLGKGQYKEAGMV 413
Query: 462 IATIFXXXXXXXXXLSNFKISKWGMYILAFIKHDKTDEVVDTIPTSPV-LDYNVYTTVLT 520
I +++ N +++W ++ F ++D +++ D +PT L VY +L
Sbjct: 414 IPSLY-----------NDNLAEWEQWVFVFAENDHLEDIADFLPTGENHLSPLVYEMILA 462
Query: 521 WYLKKSRYTELLHLLSTWSHFLYDTVLITDQ-IEDALQIKDTPILRRCLVVIYLASEQYL 579
YL T L W LY I + ++ + + + L L +YL +
Sbjct: 463 QYLATDERT-FNKKLHEWPTMLYSVSTIRNATLKKFKENQKSSTLTESLAFLYLEDNMPI 521
Query: 580 AAVRQQLILRDAAALDVLLEHNLLSNFVSELKDIVLLPFEGPIDRLNIMKLSQIKNIFQK 639
A L L +D++L+HNL + + ++L+ +G K S K+
Sbjct: 522 DAFHLYLKLHSELCIDLILQHNLYDEARASVLLLMLISSKG--------KSSDTKSAMS- 572
Query: 640 SIALLVDNRHSIPIEKLIEELSGSLQVLLFLFLQECMKIEPLMMAPYEDNMLELYLIYDK 699
++LV + HS P +++I ++ S+ L+ + E + P + Y D L+++ +D+
Sbjct: 573 --SMLVQHVHSFPPQEVIMQIH-SVPQFLYEYFCEFELMYPNSLMEYGDLKLDVFAEFDR 629
Query: 700 PGLLGFLKTKSNYNIDKAIKFCQEENNLHNELIFLWSKIGENRKALSLIIDRLDDPKLAF 759
FL Y++D A + C++ N L +EL+++ ++G N++AL LII+ L D A
Sbjct: 630 KRFFDFLVNTQCYSLDHAAQICKQYNYL-DELVYILGRMGNNKEALMLIINELLDIGRAI 688
Query: 760 QFVKDSLDNELWNFLINYSLDRPKFIKAILDSSELFEDEIATVVDKIPDNIEVEGLKKSL 819
++VK+ D ELW+ LI+YSLD+P+FI +L++ ++ ++ KIP ++ +KKS+
Sbjct: 689 RYVKEQADRELWDDLISYSLDKPEFICTLLENIGT-DENARNLLSKIPPGTKLPHMKKSI 747
Query: 820 EDIATNNELKLGVVSSIFKIVDDETKEMVAEF 851
+ +++ ++ + S +K+ +E+ M ++
Sbjct: 748 SKLLADHQSQVQLYQSCYKLFKNESISMAIKY 779
>Hs7657677 [U] KOG2066 Vacuolar assembly/sorting protein VPS41
Length = 854
Score = 241 bits (616), Expect = 3e-63
Identities = 206/814 (25%), Positives = 367/814 (44%), Gaps = 81/814 (9%)
Query: 61 KEPPLLTFSRMTQIPKTFFQRDSISACLFSDSLFAFATHSGLLHLTRPDFTTIRTFKCHR 120
+E P L + R++ Q+D+ S D A TH G ++L + F
Sbjct: 25 EEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGNITQKFDVSP 84
Query: 121 SSILSVTTD--GYYFATGSIDGTVVIGSIEDPQDISGFDFKRPIHAVILDKNY--TSTKT 176
I ++ D G + S DG V + + ++ F PI + + ++ +S K
Sbjct: 85 VKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHE-TFDCPIKIIAVHPHFVRSSCKQ 143
Query: 177 FISGGMAGEVILTQRNWLGNRTDTILEKNNGSIVGIYTIDDVVFWMNDTGITFYSTASKA 236
F++GG +++L +R+W+ +L + G+I + ++ W N+ G+ + SK
Sbjct: 144 FVTGGK--KLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDIISKQ 201
Query: 237 KLLNIPFPPDEQNRPDLYWPKVTFPETDRIIICWGSHIWQVKISILKNPEXXXXXXXXXX 296
++ N+P D RPD+Y + + + +II WG+ VK+ +K
Sbjct: 202 RITNVP-RDDISLRPDMYPCSLCWKDNVTLIIGWGT---SVKVCSVKERHASEM------ 251
Query: 297 XXXXXXRGVPDRKVELEHHVRLNCLVAGAAAFKDDQYLCLAIRQSSSGKLDT-----PEL 351
R +P R VE+ ++G A D Q + L+ + S K + P L
Sbjct: 252 ------RDLPSRYVEIVSQFETEFYISGLAPLCD-QLVVLSYVKEISEKTEREYCARPRL 304
Query: 352 KIIDILNG--EELHTYQVISKSFQNMSLNDYHLGVHIGDGKSEYYLLSSTDAIITKELSL 409
II L+ EE+ + + + FQ DYHL +G+S +Y++S D ++ KE
Sbjct: 305 DIIQPLSETCEEISSDALTVRGFQENECRDYHL--EYSEGESLFYIVSPRDVVVAKERDQ 362
Query: 410 VDRFNWYVDKKLYVKAW---EIGNYAVSPMDRLVVGLKYIDLLFSENSWTDASGAIATIF 466
D +W ++KK Y +A EI + L +GL YI+ L + A+ I
Sbjct: 363 DDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKIL 422
Query: 467 XXXXXXXXXLSNFKISKWGMYILAFIKHDKTDEVVDTIPTS-PVLDYNVYTTVLTWYLKK 525
W + F + + + +P PVL +Y +L +L+
Sbjct: 423 GKNAAL-----------WEYEVYKFKEIGQLKAISPYLPRGDPVLKPLIYEMILHEFLE- 470
Query: 526 SRYTELLHLLSTWSHFLYDTVLITDQIEDALQIKDTP--ILRRCLVVIYLASEQYLAAVR 583
S Y L+ W LY+ +I + D L+ KD+ L + L +Y + Y A+
Sbjct: 471 SDYEGFATLIREWPGDLYNNSVIVQAVRDHLK-KDSQNKTLLKTLAELYTYDKNYGNALE 529
Query: 584 QQLILRDAAALDVLLEHNLLSNFVSELKDIVLLPFEGPIDRLNIMKLSQIKNIFQKSIAL 643
L LR ++ +HNL S+ ++ ++L+ F+ +K++ +
Sbjct: 530 IYLTLRHKDVFQLIHKHNLFSSIKDKI--VLLMDFDS-----------------EKAVDM 570
Query: 644 LVDNRHSIPIEKLIEELSGSLQVLLFLFLQECMKIEPLMMAPYEDNMLELYLIYDKPGLL 703
L+DN I I+K++EEL + L ++L + K + Y + + LY YD+P LL
Sbjct: 571 LLDNEDKISIKKVVEELEDRPE-LQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLL 629
Query: 704 GFLKTKSNYNIDKAIKFCQEENNLHNELIFLWSKIGENRKALSLIIDRLDDPKLAFQFVK 763
FL+ ++ ++KA++ CQ+ N + E ++L S++G +R AL +I++ L D A +F K
Sbjct: 630 PFLRDSTHCPLEKALEICQQRNFVE-ETVYLLSRMGNSRSALKMIMEELHDVDKAIEFAK 688
Query: 764 DSLDNELWNFLINYSLDRPKFIKAILDSSELFEDEIATVVDKIPDNIEVEGLKKSLEDIA 823
+ D ELW LI YS+D+P FI +L++ D I ++ +I + +E+ L+ SL I
Sbjct: 689 EQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPI-LLIHRIKEGMEIPNLRDSLVKIL 747
Query: 824 TNNELKLGVVSSIFKIVDDETKEMVAEFLIIRKK 857
+ L++ + KI +VA+ L + KK
Sbjct: 748 QDYNLQILLREGCKKI-------LVADSLSLLKK 774
>Hs18105061 [U] KOG2066 Vacuolar assembly/sorting protein VPS41
Length = 779
Score = 222 bits (566), Expect = 2e-57
Identities = 185/715 (25%), Positives = 330/715 (45%), Gaps = 78/715 (10%)
Query: 158 FKRPIHAVILDKNY--TSTKTFISGGMAGEVILTQRNWLGNRTDTILEKNNGSIVGIYTI 215
F PI + + ++ +S K F++GG +++L +R+W+ +L + G+I +
Sbjct: 48 FDCPIKIIAVHPHFVRSSCKQFVTGGK--KLLLFERSWMNRWKSAVLHEGEGNIRSVKWR 105
Query: 216 DDVVFWMNDTGITFYSTASKAKLLNIPFPPDEQNRPDLYWPKVTFPETDRIIICWGSHIW 275
++ W N+ G+ + SK ++ N+P D RPD+Y + + + +II WG+
Sbjct: 106 GHLIAWANNMGVKIFDIISKQRITNVP-RDDISLRPDMYPCSLCWKDNVTLIIGWGT--- 161
Query: 276 QVKISILKNPEXXXXXXXXXXXXXXXXRGVPDRKVELEHHVRLNCLVAGAAAFKDDQYLC 335
VK+ +K R +P R VE+ ++G A D Q +
Sbjct: 162 SVKVCSVKERHASEM------------RDLPSRYVEIVSQFETEFYISGLAPLCD-QLVV 208
Query: 336 LAIRQSSSGKLDT-----PELKIIDILNG--EELHTYQVISKSFQNMSLNDYHLGVHIGD 388
L+ + S K + P L II L+ EE+ + + + FQ DYHL +
Sbjct: 209 LSYVKEISEKTEREYCARPRLDIIQPLSETCEEISSDALTVRGFQENECRDYHL--EYSE 266
Query: 389 GKSEYYLLSSTDAIITKELSLVDRFNWYVDKKLYVKAW---EIGNYAVSPMDRLVVGLKY 445
G+S +Y++S D ++ KE D +W ++KK Y +A EI + L +GL Y
Sbjct: 267 GESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQKNIKRHKILDIGLAY 326
Query: 446 IDLLFSENSWTDASGAIATIFXXXXXXXXXLSNFKISKWGMYILAFIKHDKTDEVVDTIP 505
I+ L + A+ I W + F + + + +P
Sbjct: 327 INHLVERGDYDIAARKCQKILGKNAAL-----------WEYEVYKFKEIGQLKAISPYLP 375
Query: 506 TS-PVLDYNVYTTVLTWYLKKSRYTELLHLLSTWSHFLYDTVLITDQIEDALQIKDTP-- 562
PVL +Y +L +L+ S Y L+ W LY+ +I + D L+ KD+
Sbjct: 376 RGDPVLKPLIYEMILHEFLE-SDYEGFATLIREWPGDLYNNSVIVQAVRDHLK-KDSQNK 433
Query: 563 ILRRCLVVIYLASEQYLAAVRQQLILRDAAALDVLLEHNLLSNFVSELKDIVLLPFEGPI 622
L + L +Y + Y A+ L LR ++ +HNL S+ ++ ++L+ F+
Sbjct: 434 TLLKTLAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKI--VLLMDFDS-- 489
Query: 623 DRLNIMKLSQIKNIFQKSIALLVDNRHSIPIEKLIEELSGSLQVLLFLFLQECMKIEPLM 682
+K++ +L+DN I I+K++EEL + L ++L + K +
Sbjct: 490 ---------------EKAVDMLLDNEDKISIKKVVEELEDRPE-LQHVYLHKLFKRDHHK 533
Query: 683 MAPYEDNMLELYLIYDKPGLLGFLKTKSNYNIDKAIKFCQEENNLHNELIFLWSKIGENR 742
Y + + LY YD+P LL FL+ ++ ++KA++ CQ+ N + E ++L S++G +R
Sbjct: 534 GQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEICQQRNFVE-ETVYLLSRMGNSR 592
Query: 743 KALSLIIDRLDDPKLAFQFVKDSLDNELWNFLINYSLDRPKFIKAILDSSELFEDEIATV 802
AL +I++ L D A +F K+ D ELW LI YS+D+P FI +L++ D I +
Sbjct: 593 SALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPFITGLLNNIGTHVDPI-LL 651
Query: 803 VDKIPDNIEVEGLKKSLEDIATNNELKLGVVSSIFKIVDDETKEMVAEFLIIRKK 857
+ +I + +E+ L+ SL I + L++ + KI +VA+ L + KK
Sbjct: 652 IHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKI-------LVADSLSLLKK 699
>At1g08190 [U] KOG2066 Vacuolar assembly/sorting protein VPS41
Length = 1000
Score = 202 bits (515), Expect = 1e-51
Identities = 193/847 (22%), Positives = 345/847 (39%), Gaps = 141/847 (16%)
Query: 61 KEPPLLTFSRMTQIPKTFFQRDSISACLFSDSLFAFATHSGLLHLTRPDFTTIRTFKCHR 120
+E P L + RM D+ S + + A TH F+ H
Sbjct: 39 EEEPRLKYQRMGGNVPALLSNDAASCIAVAARMIALGTHD--------------EFRAHT 84
Query: 121 SSI--LSVTTDGYYFATGSIDGTVVIGSIEDPQDISGFDFKRPIHAVILDKNYT--STKT 176
+ + ++ T+G Y + S DG+VVI S+ + FD+ RP+ A+ LD +YT +K
Sbjct: 85 APVNDINFDTEGEYIGSCSDDGSVVINSLFTDDEKMKFDYHRPMKAISLDPDYTKKQSKR 144
Query: 177 FISGGMAGEVILTQRNWLGNR---TDTILEKNNGSIVGIYTIDDVVFWMNDTGITFYSTA 233
F++GG+AG + + + W GN+ + +L G I + ++ W ND G+ Y TA
Sbjct: 145 FVAGGLAGHLYMNSKKWFGNKDQVCENVLHSGEGPIHSVKWRGSLIAWANDVGVKVYDTA 204
Query: 234 SKAKLLNIPFPPDEQNRPDLYWPKVTFPETDRIIICWGSHIWQVKISILKNPEXXXXXXX 293
++ I P RP+ P + + + ++I WG+ VKI+ +K+ +
Sbjct: 205 KDQRVTFIE-KPRGSPRPEALLPHLVWQDDTLLVIGWGT---SVKIASIKSDQQQTGTFR 260
Query: 294 XXXXXXXXXRGVPDRKVELEHHVRLNCLVAGAAAFKDDQYLCLAI--------------R 339
+V++ + + ++G A F D + I
Sbjct: 261 QIQMSSLT-------QVDIVASFQTSYYISGIAPFGDSLVILAYIPIEGDGEKEFSSTTT 313
Query: 340 QSSSGKLDTPELKIIDILNGEELHTYQVISKSFQNMSLNDYHL------------GVHIG 387
S G PE++I+ N +EL + F++ DY L G
Sbjct: 314 LSRQGNAQRPEIRIVS-WNNDELTMDALPVHGFEHYKAKDYSLAHAPFPGSSYAGGQWAA 372
Query: 388 DGKSEYYLLSSTDAIITKELSLVDRFNWYVDKKLYVKAW---EIGNYAVSPMDRLVVGLK 444
+ YY++S D +I K D NW + + KA E +D+ VG
Sbjct: 373 GDEPLYYIVSPKDVVIAKPRDAEDHINWLLQHGFHEKALAAVEASEGRTELIDK--VGAG 430
Query: 445 YIDLLFSENSWTDASGAIATIFXXXXXXXXXLSNFKISKWGMYILAFIKHDKTDEVVDTI 504
Y+D L E + +A+ + S W ++ F + + +V +
Sbjct: 431 YLDHLIVERKYAEAASLCPKLLRGSA-----------SAWERWVFHFAQLRQLPVLVPYM 479
Query: 505 PT-SPVLDYNVYTTVLTWYLKKSRY-TELLHLLSTWSHFLYDTVLITDQIEDALQ----- 557
PT +P L VY L Y ELL + +W +Y + + IE L
Sbjct: 480 PTDNPRLKDTVYEVALVALATNPSYHKELLSAVKSWPRSVYSALTVISAIEPQLNTSSMT 539
Query: 558 --IKDTPILRRCLVVIYLASEQYLAAVRQQLILRDAAALDVLLEHNLLSNFVSELKDIVL 615
+K+ I+ L +Y+ QY A L D + +++L ++ ++L
Sbjct: 540 DALKEVSIVCHALAELYVIDGQYQKAFSLYADLLKPEVFDFIEKYSLHEAIRGKVVQLML 599
Query: 616 LPFEGPIDRLNIMKLSQIKNIFQKSIALLVDNRHSIPIEKLIEEL---SGSLQVL----- 667
L +++ L + NR IP +++ +L + QVL
Sbjct: 600 LD-------------------CKRATVLFIQNRDLIPPSEVVPQLLKAGKNPQVLKAGKK 640
Query: 668 ------LFLFLQECMKIEPLMMAPYEDNMLELYLIYDKPGLLGFLKTKSNYNIDKAIKFC 721
L+L+L ++ + D +ELY YD LL FL++ +Y ++KA + C
Sbjct: 641 CDSRYYLYLYLHALFEVSHDTGKDFHDMQVELYAEYDTKMLLPFLRSSQHYKLEKAYELC 700
Query: 722 QEENNLHNELIFLWSKIGENRKALSLIIDRLDDPK----LAFQFVKDSLDNELWNFLINY 777
+++ L E +F+ ++G ++AL++II++L D + A +FV D++LW LI
Sbjct: 701 VKKDFL-REQVFVLGRMGNAKQALAVIINKLGDIEEVIVTAVEFVSMQHDDDLWEELIKQ 759
Query: 778 SLDRPKFIKAI----------LDSSE----LFEDEIAT-----VVDKIPDNIEVEGLKKS 818
L++P+ +KA+ LDS + L E + +V+ +P+ +E+ L+
Sbjct: 760 CLNKPEMVKAVFVMQITTQTSLDSGKLVGLLLEHTVGNLDPLYIVNMVPNGLEIPRLRDR 819
Query: 819 LEDIATN 825
L I T+
Sbjct: 820 LVKIVTD 826
>7289410 [U] KOG2066 Vacuolar assembly/sorting protein VPS41
Length = 841
Score = 168 bits (426), Expect = 3e-41
Identities = 186/814 (22%), Positives = 351/814 (42%), Gaps = 73/814 (8%)
Query: 64 PLLTFSRMTQIPKTFFQRDSISACLFSDSLFAFATHSGLL----HLTRPDFTTIRTFKCH 119
P + R+ K D I+ F T G + H ++ + + H
Sbjct: 24 PKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYSNLSASERH 83
Query: 120 RSSI----LSVTTDGYYFATGSIDGTVVIGSIEDPQDISGFDFKRPIHAVILDKNYTS-T 174
+ + V G Y AT S DG V I + + F + I V L+ + +
Sbjct: 84 THQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPDSKAHI 143
Query: 175 KTFISGGMAGEVILTQRNWLGNRTDTILEKNNGSIVGIYTIDDVVFWMNDTGITFYSTAS 234
K F+ G ++IL +RN L L GS++ I + + W + G+ Y
Sbjct: 144 KRFVVGD--DKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNE 201
Query: 235 KAKLLNIPFPPDEQNRPDLYWPKVTFPETDRIIICWGSHIWQVKISILKNPEXXXXXXXX 294
+ L I + Q R + + + + ++I W + +++ +++
Sbjct: 202 RCSLGLIKWEVPPQERLENFRCHLRWSNKHTLLIGW---VDTIRVCVIRKRNSIEASTG- 257
Query: 295 XXXXXXXXRGVPDRKVELEHHVRLNCLVAGAAAFKDDQYLCLAIRQSSSG--KLDTPELK 352
+P V+ + V G A Q + L R+ S K P L
Sbjct: 258 ---------NLPVYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSSCFKALRPVLC 308
Query: 353 IID--ILNGEELHTYQVISKSFQNMSLNDYHLGVHIGDGKSEYYLLSSTDAIITKELSLV 410
+I+ + N EE+ T + + F+ ++NDY LG I + + +Y+++ D ++ +
Sbjct: 309 VIEYKMNNSEEICTDSLTLRGFEEYTVNDYSLGGIIEENR--FYIVAPKDIVVASLIETD 366
Query: 411 DRFNWYVDKKLYVKAWEIGNYAVSPMDRLVVGLKYIDLLFSENSWTDASGAIATIFXXXX 470
DR W + + +A E+ + + L V YI+ L + + DA+ +
Sbjct: 367 DRIEWLIKHSKFEEAMELISANGGNVPVLSVAKLYINHLLALKKYDDAAKLCLRM----- 421
Query: 471 XXXXXLSNFKISKWGMYILAFIKHDKTDEVVDTIPTSPV--LDYNVYTTVLTWYLKKSRY 528
L N K+ W + F+K + V +PTS LD +VY VL +LK
Sbjct: 422 -----LGNDKVL-WEEEVFKFVKCQQLRSVSAYLPTSDECKLDPHVYEMVLYEFLKFD-V 474
Query: 529 TELLHLLSTWSHFLYDTVLITDQIEDALQIKDTPILRRCLVVIYLASEQYLAAVRQQLIL 588
L+L+ W LYD + + + I D + L L ++Y + +A+R L L
Sbjct: 475 CGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQLLESLALLYSYQGDFESALRMYLKL 534
Query: 589 RDAAALDVLLEHNLLSNFVSELKDIVLLPFEGPIDRLNIMKLSQIKNIFQKSIALLVDNR 648
++ ++ + L + +S+L I+ L Q+ + +L+D +
Sbjct: 535 QNKDVFQLIRRYELY-DVISKL----------------IIPLIQLDR--DCAFEILLDKK 575
Query: 649 HSIPIEKLIEELSGSLQVLLFLFLQECMKIEPLMMAPYEDNMLELYLIYDKPGLLGFLKT 708
I E ++ +L + Q L+ +L +K +P + ++ ++ LY I+D+ LL FLK
Sbjct: 576 -KIKTEIVVHQLEHN-QEYLYWYLDSLLKKDPSNV--FQKKLISLYAIFDRNKLLPFLKR 631
Query: 709 KSNYNIDKAIKFCQEENNLHNELIFLWSKIG--ENRKALSLIIDRLDDPKLAFQFVKDSL 766
+Y+I +A+ C++EN + E+++L +G E +AL++II R+ D ++A +F K+
Sbjct: 632 SKDYDIQEALVICKQEN-FYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHD 690
Query: 767 DNELWNFLINYSLDRPKFIKAILDS-SELFEDEIATVVDKIPDNIEVEGLKKSLEDIATN 825
D++LWN LIN P+ + +LD + F A VV KI + L++SL + +
Sbjct: 691 DSDLWNALINEFSKHPEIVTKVLDGIVDYFSP--AVVVGKIKMGQNIPNLRQSLIKMLRH 748
Query: 826 NELKLGVVSSIFKIVDDETKEMVAEFLIIRKKGK 859
L+ ++SS +I ++ E+ +E + +++G+
Sbjct: 749 YNLQGEILSSAQQIQLNDYFEIHSEIVTTQRRGQ 782
>CE29305_2 [U] KOG2066 Vacuolar assembly/sorting protein VPS41
Length = 807
Score = 97.4 bits (241), Expect = 8e-20
Identities = 93/443 (20%), Positives = 192/443 (42%), Gaps = 45/443 (10%)
Query: 393 YYLLSSTDAIITKELSLVDRFNWYVDKKLYVKAWEIGNYAVSPMDRLVVGLKYIDLLFSE 452
Y++L++ I+ D W + KLY +A ++ + + + + K + + E
Sbjct: 290 YFILTTKHIIMAVPYGPEDGIRWRLKYKLYDEALDMAKHNADLLSKTDLSPKKVGRMIIE 349
Query: 453 NSWTDASGAIATIFXXXXXXXXXLSNFKISKWGMYILAFIKHDKTDEVVDTIPT-SPVLD 511
T A + +W + F + + + +P +P LD
Sbjct: 350 GYLTGKRARAAA------SRLPLICGECKEEWEWAVNQFEEVKLCTLLAEVLPDGTPTLD 403
Query: 512 YNVYTTVLTWYLKKSRYTELLHLLSTWSHFLYDTVLITDQIEDALQ----------IKDT 561
Y VL L + + L+ TWS LY T I D+ + +Q + +T
Sbjct: 404 PECYQKVLIACLFNN-VKQFRKLVQTWSPDLYMTSFIIDRTQWRIQQISKSGNLADVDET 462
Query: 562 P-ILRRCLVVIYLASEQYLAAVRQQLILRDAAALDVLLEHNLLSNFVSELKDIVLLPFEG 620
+L L +YL +Y +A++ + +D +V+ +H L ++ +++ + E
Sbjct: 463 ERVLMDALAHLYLYERKYESALKILMSCQDFQIFNVIDKHQLFDLVKDQITELMNINSE- 521
Query: 621 PIDRLNIMKLSQIKNIFQKSIALLVDNRHSIPIEKLIEELSGSLQVLLFLFLQECMKIEP 680
+++ LL+DN S+ ++E++ G L +L + M
Sbjct: 522 ------------------RALRLLLDNADSVEPSFVMEKI-GRQPKLQLAYLTKLMSRNE 562
Query: 681 LMMAPYEDNMLELYLIYDKPGLLGFLKTKSNYNIDKAIKFCQEENNLHNELIFLWSKIGE 740
+ D ++LY YD+ LL FL+ +NYN++KA K C ++ + E I+L +K G
Sbjct: 563 --GTEFADKAVQLYAEYDQKKLLPFLRKNANYNVNKARKLCSDKGYI-EETIYLLAKSGN 619
Query: 741 NRKALSLIIDRLDDPKLAFQFVKDSLDNELWNFLINYSLDRP-KFIKAILDSSELFEDEI 799
+ A+ +++ + + + KD D +LW L+ + P F + I+++S + +
Sbjct: 620 HYDAVKMMVREYRNMEKVIDYCKDQNDPDLWIHLLGVVAEFPAHFSQLIIEASNCLDPLL 679
Query: 800 ATVVDKIPDNIEVEGLKKSLEDI 822
++DK+PD+ ++ L ++L+ +
Sbjct: 680 --IMDKLPDDSDIPNLSEALDKL 700
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.139 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,184,302
Number of Sequences: 60738
Number of extensions: 2093160
Number of successful extensions: 5608
Number of sequences better than 1.0e-05: 7
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 5553
Number of HSP's gapped (non-prelim): 8
length of query: 863
length of database: 30,389,216
effective HSP length: 115
effective length of query: 748
effective length of database: 23,404,346
effective search space: 17506450808
effective search space used: 17506450808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)