ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII2968 good IT KOG1435 Lipid transport and metabolism Sterol reductase/lamin B receptor
r_klactIII2968 good IT KOG1435 Signal transduction mechanisms Sterol reductase/lamin B receptor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII2968 1042486 1041164 -441
(441 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL280c [IT] KOG1435 Sterol reductase/lamin B receptor 620 e-177
SPBC16G5.18 [IT] KOG1435 Sterol reductase/lamin B receptor 309 5e-84
Hs20537133 [IT] KOG1435 Sterol reductase/lamin B receptor 260 3e-69
Hs4504961 [IT] KOG1435 Sterol reductase/lamin B receptor 260 3e-69
Hs4507547 [IT] KOG1435 Sterol reductase/lamin B receptor 220 4e-57
Hs4503321 [IT] KOG1435 Sterol reductase/lamin B receptor 180 3e-45
SPAC20G4.07c [IT] KOG1435 Sterol reductase/lamin B receptor 165 1e-40
At1g50430 [IT] KOG1435 Sterol reductase/lamin B receptor 153 4e-37
YGL012w [IT] KOG1435 Sterol reductase/lamin B receptor 150 5e-36
At3g52940 [IT] KOG1435 Sterol reductase/lamin B receptor 137 2e-32
CE19655_2 [IT] KOG1435 Sterol reductase/lamin B receptor 90 8e-18
>YNL280c [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 438
Score = 620 bits (1598), Expect = e-177
Identities = 299/437 (68%), Positives = 347/437 (78%), Gaps = 1/437 (0%)
Query: 6 MTALNPKTTHYEFSGPVGALLISVFLPILTVILNQLIRPDYHIVGLFRNFSWIEVWNKVN 65
++ALNP+TT +EF G +GAL IS+ LP+ T+ILNQ+IRPDY I G F+NF +E+WN +
Sbjct: 2 VSALNPRTTEFEFGGLIGALGISIGLPVFTIILNQMIRPDYFIKGFFQNFDIVELWNGIK 61
Query: 66 PLSSYLFNGELWTYYSAWFFSLAVLDVLLPGTKLYGVELRDGSKLPYKINGIAVSMALTL 125
PL YL N ELWT Y W+ LAVLDV+LPG + GV+LRDGSKL YKINGIA+S L L
Sbjct: 62 PLRYYLGNRELWTVYCLWYGILAVLDVILPGRVMKGVQLRDGSKLSYKINGIAMSTTLVL 121
Query: 126 VLAVRYQLTNGEMPELQYLFEHQTDICXXXXXXXXXXACFVYIGSFVPL-WGTNGKGTKE 184
VLA+R++LT+G++PELQYL+E+ +C A + Y+ SF+PL + NG G +E
Sbjct: 122 VLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKKNGNGKRE 181
Query: 185 RILAVGGNSGNILYDWFIGRELNPRIGPLDIKMFAELRPGMLLWFLINLSCLHHSYRESG 244
+ILA+GGNSGNI+YDWFIGRELNPR+GPLDIKMF+ELRPGMLLW LINLSCLHH Y ++G
Sbjct: 182 KILALGGNSGNIIYDWFIGRELNPRLGPLDIKMFSELRPGMLLWLLINLSCLHHHYLKTG 241
Query: 245 KIYDSLLLVNVLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYCLQARY 304
KI D+L+LVN LQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTY LQARY
Sbjct: 242 KINDALVLVNFLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYSLQARY 301
Query: 305 LAVSPIEFGLPHSTLIVIIMLLGYWIFHSANKQKSDFRQGKLPQLKSIQTDKGTKLLCDS 364
L+VSP+E G I+ IM LG+ IFHSANKQKS+FRQGKL LKSIQT +GTKLLCD
Sbjct: 302 LSVSPVELGWVKVVGILAIMFLGFHIFHSANKQKSEFRQGKLENLKSIQTKRGTKLLCDG 361
Query: 365 WWAVSQHINYFGDLLISLSWCLATGFQTPLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVF 424
WWA SQHINYFGD LISLSWCLAT FQTPLT HRQ RDE KCR KYG
Sbjct: 362 WWAKSQHINYFGDWLISLSWCLATWFQTPLTYYYSLYFATLLLHRQQRDEHKCRLKYGEN 421
Query: 425 WEEYERKVPYKIVPYVY 441
WEEYERKVPYKI+PYVY
Sbjct: 422 WEEYERKVPYKIIPYVY 438
>SPBC16G5.18 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 424
Score = 309 bits (792), Expect = 5e-84
Identities = 176/440 (40%), Positives = 246/440 (55%), Gaps = 26/440 (5%)
Query: 8 ALNPKTTHYEFSGPVGALLISVFLPILTVILNQLIRPDYHIVGLFRNFSWIEVWNKVNPL 67
A+ + YEF GP+GAL ++V +++ + + G FS I K PL
Sbjct: 5 AVKKEKFEYEFFGPIGALGVTVLTTVVSFGSFYICNEE----GCPAKFSKISHIFKKTPL 60
Query: 68 SSYLFNGELWTYYSAWFFSLAVLDVLLPGTKLYGVELRD-GSKLPYKINGIAVSMALTLV 126
F+ + Y WF +L +L G G + D G++L YKING + + V
Sbjct: 61 ----FDQKSLILYLLWFSTLTLLWKCTNGKWAKGTPIDDKGTRLLYKINGFNSACLILGV 116
Query: 127 LAVRYQLTNGEMPELQYLFEHQTDICXXXXXXXXXXACFVYIGSFVPLWGTNGKGTKERI 186
+ L +++++++ + F Y+ SF GK +
Sbjct: 117 VCTSIYLLGASC--MEFIWDNFLQLMFAAYVFSVVLCTFCYVQSFF------GK----QQ 164
Query: 187 LAVGGNSGNILYDWFIGRELNPRIGPLDIKMFAELRPGMLLWFLINLSCLHHSYRE-SGK 245
LA GG SGNIL+DWFIGR LNPRIG DIK F ELRPG++LW + +++ H Y G+
Sbjct: 165 LAKGGTSGNILFDWFIGRSLNPRIGNFDIKCFCELRPGLILWVVFDIAFACHQYLVLGGR 224
Query: 246 IYDSLLLVNVLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYCLQARYL 305
I DS++LV + +Y+ D ++NE VLT MDITTDGFG+ML+FGDL VPF Y LQARYL
Sbjct: 225 ITDSMVLVIIFHTWYVLDSLINESAVLTTMDITTDGFGYMLSFGDLVWVPFLYSLQARYL 284
Query: 306 AVSPIEFGLPHSTLIVIIMLLGYWIFHSANKQKSDFRQG----KLPQLKSIQTDKGTKLL 361
A P++ GL + I+ + LGY+IF AN QK+ FR KL LK IQT +GTKLL
Sbjct: 285 AFHPVDLGLVKTLAILCLQFLGYYIFRGANGQKNRFRSNPNDPKLKHLKFIQTKRGTKLL 344
Query: 362 CDSWWAVSQHINYFGDLLISLSWCLATGFQTPLTXXXXXXXXXXXXHRQSRDEEKCRNKY 421
WW +++HINYFGD +++ +WCL GF +P+ HR +RD+ KCR KY
Sbjct: 345 TSGWWGMARHINYFGDWIMAWAWCLPAGFGSPIPYFYVAYFGVLLVHRNARDDHKCRVKY 404
Query: 422 GVFWEEYERKVPYKIVPYVY 441
G WE+Y + V Y+I+PYVY
Sbjct: 405 GEDWEKYCKAVKYRIIPYVY 424
>Hs20537133 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 615
Score = 260 bits (665), Expect = 3e-69
Identities = 163/434 (37%), Positives = 222/434 (50%), Gaps = 35/434 (8%)
Query: 17 EFSGPVGALLISVFLPILTVILNQLIRPDYHIVGLFRNFSWIEVWNKVNPLSSY--LFNG 74
EF G G LI LP+ +L + + + N PL + L+
Sbjct: 208 EFGGVPGVFLIMFGLPVFLFLLLLMCKQKDP-----------SLLNFPPPLPALYELWET 256
Query: 75 ELWTYYSAWFFSLAVLDVLLP-GTKLYGVELRDGSKLPYKINGIAVSMALTLVLAVRYQL 133
++ Y WF + VL LLP G + G L DG +L Y++NG + + V+ L
Sbjct: 257 RVFGVYLLWFL-IQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILTSAVIGT--SL 313
Query: 134 TNGEMPELQYLFEHQTDICXXXXXXXXXXACFVYIGSFVPLWGTNGKGTKERILAVGGNS 193
G E Y++ H + ++Y+ S K + + +S
Sbjct: 314 FQGV--EFHYVYSHFLQFALAATVFCVVLSVYLYMRSL--------KAPRNDLSPA--SS 361
Query: 194 GNILYDWFIGRELNPRIGPLDIKMFAELRPGMLLWFLINLSCLHHSYRESGKIYDSL--L 251
GN +YD+FIGRELNPRIG D+K F ELRPG++ W +INL L + + SL +
Sbjct: 362 GNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMI 421
Query: 252 LVNVLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYCLQARYLAVSPIE 311
LVN Q Y+ D + NEE +LT MDI DGFGFMLAFGDL VPF Y QA YL P E
Sbjct: 422 LVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNE 481
Query: 312 FGLPHSTLIVIIMLLGYWIFHSANKQKSDFRQG----KLPQLKSIQTDKGTKLLCDSWWA 367
P ++LI+++ L GY IF AN QK+ FR+ KL LK+I T G LL WW
Sbjct: 482 VSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWG 541
Query: 368 VSQHINYFGDLLISLSWCLATGFQTPLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVFWEE 427
+H NY GDL+++L+W L GF L HR++RDE C+ KYGV WE+
Sbjct: 542 FVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEK 601
Query: 428 YERKVPYKIVPYVY 441
Y ++VPY+I PY+Y
Sbjct: 602 YCQRVPYRIFPYIY 615
>Hs4504961 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 615
Score = 260 bits (664), Expect = 3e-69
Identities = 163/434 (37%), Positives = 222/434 (50%), Gaps = 35/434 (8%)
Query: 17 EFSGPVGALLISVFLPILTVILNQLIRPDYHIVGLFRNFSWIEVWNKVNPLSSY--LFNG 74
EF G G LI LP+ +L + + + N PL + L+
Sbjct: 208 EFGGVPGVFLIMFGLPVFLFLLLLMCKQKDP-----------SLLNFPPPLPALYELWET 256
Query: 75 ELWTYYSAWFFSLAVLDVLLP-GTKLYGVELRDGSKLPYKINGIAVSMALTLVLAVRYQL 133
++ Y WF + VL LLP G + G L DG +L Y++NG + + V+ L
Sbjct: 257 RVFGVYLLWFL-IQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYPFILTSAVIGT--SL 313
Query: 134 TNGEMPELQYLFEHQTDICXXXXXXXXXXACFVYIGSFVPLWGTNGKGTKERILAVGGNS 193
G E Y++ H + ++Y+ S K + + +S
Sbjct: 314 FQGV--EFHYVYSHFLQFALAATVFCVVLSVYLYMRSL--------KAPRNDLSPA--SS 361
Query: 194 GNILYDWFIGRELNPRIGPLDIKMFAELRPGMLLWFLINLSCLHHSYRESGKIYDSL--L 251
GN +YD+FIGRELNPRIG D+K F ELRPG++ W +INL L + + SL +
Sbjct: 362 GNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMI 421
Query: 252 LVNVLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYCLQARYLAVSPIE 311
LVN Q Y+ D + NEE +LT MDI DGFGFMLAFGDL VPF Y QA YL P E
Sbjct: 422 LVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNE 481
Query: 312 FGLPHSTLIVIIMLLGYWIFHSANKQKSDFRQG----KLPQLKSIQTDKGTKLLCDSWWA 367
P ++LI+++ L GY IF AN QK+ FR+ KL LK+I T G LL WW
Sbjct: 482 VSWPMASLIIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSSGKNLLVSGWWG 541
Query: 368 VSQHINYFGDLLISLSWCLATGFQTPLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVFWEE 427
+H NY GDL+++L+W L GF L HR++RDE C+ KYGV WE+
Sbjct: 542 FVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEK 601
Query: 428 YERKVPYKIVPYVY 441
Y ++VPY+I PY+Y
Sbjct: 602 YCQRVPYRIFPYIY 615
>Hs4507547 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 589
Score = 220 bits (560), Expect = 4e-57
Identities = 133/326 (40%), Positives = 179/326 (54%), Gaps = 22/326 (6%)
Query: 101 GVELRDGSKLPYKINGIA--VSMALTLVLAVRYQLTNGEMPELQYLFEHQTDICXXXXXX 158
G EL+D S+L Y ING V AL + L + L G +PE+ +
Sbjct: 221 GQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLL------PLAFVATLT 274
Query: 159 XXXXACFVYIGSFVPLWGTNGKGTKERILAVGGNSGNILYDWFIGRELNPRIGPLDIKMF 218
+ F+Y+ + V LA GGNSGN +YD+F+GRELNPRI D K F
Sbjct: 275 AFIFSLFLYMKAQV---------APVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYF 325
Query: 219 AELRPGMLLWFLINLSCLHHSYRESGKIYDSLLLVNVLQGFYIFDGVLNEEGVLTMMDIT 278
ELRPG++ W LINL+ L G ++ LVN Q Y+ D + +EE VLT MDIT
Sbjct: 326 CELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDIT 385
Query: 279 TDGFGFMLAFGDLSLVPFTYCLQARYLAVSPIEFGLPHSTLIVIIMLLGYWIFHSANKQK 338
DGFGFMLAFGD++ VPFTY LQA++L P GLP +++I +I GY+IF AN QK
Sbjct: 386 HDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQK 445
Query: 339 SDFRQG----KLPQLKSIQTDKGTKLLCDSWWAVSQHINYFGDLLISLSWCLATGFQTPL 394
+ FR+ ++ L++I T G KLL WW + +H NY GDL+++L+W L G L
Sbjct: 446 NTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLL 505
Query: 395 TXXXXXXXXXXXXHRQSRDEEK-CRN 419
HR++RDE CR+
Sbjct: 506 PYFYLLYFTALLVHREARDERSACRS 531
>Hs4503321 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 475
Score = 180 bits (457), Expect = 3e-45
Identities = 123/410 (30%), Positives = 193/410 (47%), Gaps = 45/410 (10%)
Query: 59 EVWNKVNPLS---SYLFNGELWTYYSAWFFSLA--VLDVLLPGTKLYGVELRDGSKLP-- 111
++W K P++ + L+ LW + ++ LPG Y +++G+ P
Sbjct: 84 DIWAKTPPITRKAAQLYT--LWVTFQVLLYTSLPDFCHKFLPG---YVGGIQEGAVTPAG 138
Query: 112 ----YKINGIAVSMALTLVLAVRYQLTNGEMPELQYLFEHQTDICXXXXXXXXXXACFVY 167
Y+ING+ + L+ L + P + +F++ + + F
Sbjct: 139 VVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTI--IFDNWIPLLWCANILGYAVSTFAM 196
Query: 168 I-GSFVPLWGTNGKGTKERILAVGGNSGNILYDWFIGRELNPRIGP-LDIKMFAELRPGM 225
+ G F P + K T GN Y++ +G E NPRIG D K+F RPG+
Sbjct: 197 VKGYFFPTSARDCKFT-----------GNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGI 245
Query: 226 LLWFLINLSCLHHSYRESGKIYDSLLLVNVLQGFYIFDGVLNEEGVLTMMDITTDGFGFM 285
+ W LINLS + ++++LVNVLQ Y+ D NE L +DI D FG+
Sbjct: 246 VAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWY 305
Query: 286 LAFGDLSLVPFTYCLQARYLAVSPIEFGLPHSTLIVIIMLLGYWIFHSANKQKSDFRQ-- 343
L +GD +P+ Y LQ YL P++ PH+ ++++ L+GY+IF AN QK FR+
Sbjct: 306 LGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTD 365
Query: 344 ------GKLPQLKSIQTDKG------TKLLCDSWWAVSQHINYFGDLLISLSWCLATGFQ 391
G+ P++ +KLL +W V++H NY GDL+ SL++CLA G
Sbjct: 366 GRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGG 425
Query: 392 TPLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVFWEEYERKVPYKIVPYVY 441
L HR RDE +C +KYG WE Y VPY+++P ++
Sbjct: 426 HLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF 475
>SPAC20G4.07c [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 453
Score = 165 bits (417), Expect = 1e-40
Identities = 142/469 (30%), Positives = 213/469 (45%), Gaps = 61/469 (13%)
Query: 12 KTTHYEFSGPVGALLISVFLPILTVIL--------NQLIRPDYHIVGLFRNFSWIEVWNK 63
K+ EF G GAL I P L L +Q I+P+ + F+NF
Sbjct: 7 KSAPREFGGAKGALAIMTGFPCLMYYLWACSKFNDSQFIKPESFTIAGFQNF-------- 58
Query: 64 VNPLSSYLFNGELWTYYS---AWFFSL--AVLDVLLPGTKLYGVEL--RDGSKLPYKING 116
L Y++ G T Y+ W F + AV+ + LPG + G+ L R+ +LPY N
Sbjct: 59 FRTLGHYIYVGAYPTRYAFLVFWSFCIVQAVMYLTLPGVRTQGLPLKHRNNERLPYLCNA 118
Query: 117 IAVSMALTLVLAVRYQLTNGEMPELQYLFEHQTDICXXXXXXXXXXACFVYIGSFVPLWG 176
I ++LAV + + ++F T I ++ +FV G
Sbjct: 119 IWSFYTTIVILAVLH---------VTHVFPITTFI-DMFGPLMSVAIITAFVCTFVLYTG 168
Query: 177 TNGKGTKERILAVGGN-SGNILYDWFIGRELNPRIGP-LDIKMFAELRPGMLLWFLINLS 234
T G +R+ SGN +YD F+G LNPR+G LD KMF E+R + F I++
Sbjct: 169 TLLFG--DRLFDKPHRLSGNPIYDAFMGACLNPRLGKLLDFKMFFEVRIPWFILFFISVG 226
Query: 235 CLHHSYRESGKIYDSLLLVNVLQGFYIFDGVLN--EEGVLTMMDITTDGFGFMLAFGDLS 292
Y G + +L V + G Y++ + E+ ++ D+ + FGFML F +++
Sbjct: 227 AAVRQYETYGTVSPQVLFVCL--GHYLYANACSKGEQLIVPTWDMAYEKFGFMLIFWNMA 284
Query: 293 LVPFTYCLQARYL---AVSPIEFGLPHSTLIVIIMLLGYWIFHSANKQKSDFR------- 342
VPFTY YL S + ++T I +++L Y+IF + N QK+ FR
Sbjct: 285 GVPFTYSHCTLYLFSHDPSVYNWSTQYTTGIYVLLLCCYYIFDTCNGQKNHFRNQIYGTE 344
Query: 343 --QGKLPQL--------KSIQTDKGTKLLCDSWWAVSQHINYFGDLLISLSWCLATGFQT 392
+ PQL I+ G LL W+ ++ I+Y D SLSW L TGFQ+
Sbjct: 345 VHRKTFPQLPWLIIKNPTFIRCANGGTLLTSGWYRYARKIHYTADFFQSLSWALITGFQS 404
Query: 393 PLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVFWEEYERKVPYKIVPYVY 441
PL HR SRD +KC+ KYG ++EY R PY +PY++
Sbjct: 405 PLPYFYPCFFFVVLVHRVSRDIKKCKAKYGADFDEYCRICPYLFIPYIF 453
>At1g50430 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 432
Score = 153 bits (387), Expect = 4e-37
Identities = 105/369 (28%), Positives = 171/369 (45%), Gaps = 29/369 (7%)
Query: 88 AVLDVLLPGTKLYGVELRDGSKLPYKINGIAVSMALTLVLAVRYQLTNGEMPELQYLFEH 147
A+L +LLPG ++ G G++ YK NG+A A + LA L + +++H
Sbjct: 78 AILQLLLPGKRVEGPISPAGNRPVYKANGLA---AYFVTLATYLGLWWFGIFNPAIVYDH 134
Query: 148 QTDICXXXXXXXXXXACFVYIGSFVPLWGTNGKGTKERILAVGGNSGNILYDWFIGRELN 207
+I +YI KG + G+ GN++ D++ G EL
Sbjct: 135 LGEIFSALIFGSFIFCVLLYI-----------KGHVAPSSSDSGSCGNLIIDFYWGMELY 183
Query: 208 PRIGP-LDIKMFAELRPGMLLWFLINLSCLHHSYRESGKIYDSLLLVNVLQGFYIFDGVL 266
PRIG DIK+F R GM+ W ++ ++ Y +GK+ DS+L+ +L Y+
Sbjct: 184 PRIGKSFDIKVFTNCRFGMMSWAVLAVTYCIKQYEINGKVSDSMLVNTILMLVYVTKFFW 243
Query: 267 NEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYCLQARYLAVSPIEFGLPHSTLIVIIMLL 326
E G MDI D GF + +G L VP Y YL P+E G + I++ +L
Sbjct: 244 WEAGYWNTMDIAHDRAGFYICWGCLVWVPSVYTSPGMYLVNHPVELGTQLAIYILVAGIL 303
Query: 327 GYWIFHSANKQKSDFRQ--------GKLPQ--LKSIQTDKG----TKLLCDSWWAVSQHI 372
+I + ++Q+ +FR+ G+ P + S T G + LL WW +++H
Sbjct: 304 CIYINYDCDRQRQEFRRTNGKCLVWGRAPSKIVASYTTTSGETKTSLLLTSGWWGLARHF 363
Query: 373 NYFGDLLISLSWCLATGFQTPLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVFWEEYERKV 432
+Y ++L + W + F L R RD+++CR+KYG +W+ Y KV
Sbjct: 364 HYVPEILSAFFWTVPALFDNFLAYFYVIFLTLLLFDRAKRDDDRCRSKYGKYWKLYCEKV 423
Query: 433 PYKIVPYVY 441
Y+I+P +Y
Sbjct: 424 KYRIIPGIY 432
>YGL012w [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 473
Score = 150 bits (378), Expect = 5e-36
Identities = 129/463 (27%), Positives = 200/463 (42%), Gaps = 50/463 (10%)
Query: 9 LNPKTTHYEFSGPVGALLISVFLPILTVILNQLIRPDYH--IVGLFRNFSWIEVWNKVNP 66
L P YEF G G + + + P+L + + YH + SW+ +
Sbjct: 31 LKPNEIEYEFGGTTGVIGMLIGFPLLMYYM-WICAEFYHGKVALPKAGESWMHFIKHLYQ 89
Query: 67 LSSYLFNGEL----WTYYSAWFFSLAVLDVLLPGTKLYGVELRD--GSKLPYKINGI-AV 119
L L NG WT + ++ + LPG G L G +LPY N + +
Sbjct: 90 L--VLENGIPEKYDWTIFLTFWVFQIIFYYTLPGIWTKGQPLSHLKGKQLPYFCNAMWTL 147
Query: 120 SMALTLVLAVRYQLTNGEMPELQYLFEHQTDICXXXXXXXXXXACFVYIGSFVPLWGTNG 179
+ TLVL + + TN + L + + I + +Y LW
Sbjct: 148 YVTTTLVLVLHF--TN--LFRLYVIIDRFGRIMTCAIISGFAFSIILY------LWTLFI 197
Query: 180 KGTKERILAVGGNSGNILYDWFIGRELNPRIGPLDIKMFAELR-PGMLLWFLINLSCLHH 238
R+ +GN LYD+F+G LNPR G LD+KMF E+R P L+F+ +CL
Sbjct: 198 SHDYHRM------TGNHLYDFFMGAPLNPRWGILDLKMFFEVRLPWFTLYFITLGACL-K 250
Query: 239 SYRESGKIYDSLLLVNVLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTY 298
+ G + L +V + Y EE ++ D+ + FGFML F +++ VP+TY
Sbjct: 251 QWETYGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTY 310
Query: 299 C---LQARYLAVSPIEFGLPHSTLIVIIMLLGYWIFHSANKQKSDFRQGK---------- 345
C L Y S + ++ + +++L Y+ F +AN QK+ FR+
Sbjct: 311 CHCTLYLYYHDPSEYHWSTLYNVSLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTF 370
Query: 346 -------LPQLKSIQTDKGTKLLCDSWWAVSQHINYFGDLLISLSWCLATGFQTPLTXXX 398
L K + T G+ LL D W+ +++ I+Y D SL W L+ GF +
Sbjct: 371 PFLPYQILKNPKYMVTSNGSYLLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFF 430
Query: 399 XXXXXXXXXHRQSRDEEKCRNKYGVFWEEYERKVPYKIVPYVY 441
HR RD+ KC+ KYG W+EY + PY +PYV+
Sbjct: 431 PVFFLVVLIHRAFRDQAKCKRKYGKDWDEYCKHCPYVFIPYVF 473
>At3g52940 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 317
Score = 137 bits (346), Expect = 2e-32
Identities = 101/360 (28%), Positives = 160/360 (44%), Gaps = 62/360 (17%)
Query: 83 WFFSLAVLDVLLPGTKLYGVELRDGSKLPYKINGIAVSMALTLVLAVRYQLTNGEMPELQ 142
+F LAV +LPG + GV L DGS+L Y+ NG+ + L +L + +L G + L
Sbjct: 19 YFVYLAVAGEILPGKVIRGVLLSDGSQLRYRCNGLLALILLVAILGICAKL--GIVSPLV 76
Query: 143 YLFEHQTDICXXXXXXXXXXACFVYIGSFVPLWGTNGKGTKERILAVGGNSGNILYDWFI 202
D V + +V ++ KG+ + SGN+++DW+
Sbjct: 77 V-----ADRGLELLSATFIFCVLVTLALYVTGRSSSNKGSSLKPHV----SGNLVHDWWF 127
Query: 203 GRELNPRIGPLDIKMFAELRPGMLLWFLINLSCLHHSYRESGKIYDSLLLVNVLQGFYIF 262
G +LNP+ +D+K GM+ W LINLS L S ++ G + S++L +
Sbjct: 128 GIQLNPQFMSIDLKA------GMMGWLLINLSILAKSVQD-GSLSQSMILYQI------- 173
Query: 263 DGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYCLQARYLAVSPIEFGLPHSTLIVI 322
+C +L + +E +P + +
Sbjct: 174 -----------------------------------FCA-GWWLLHNKVELTVPAIVVNCL 197
Query: 323 IMLLGYWIFHSANKQKSDFRQG-KLPQLKSIQTDKGTKLLCDSWWAVSQHINYFGDLLIS 381
+ L+GY +F ANKQK F++ K P G KLL +W +++H NY GDL+++
Sbjct: 198 VFLIGYMVFRGANKQKHIFKKNPKTPIWGKPPVVVGGKLLVSGYWGIARHCNYLGDLMLA 257
Query: 382 LSWCLATGFQTPLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVFWEEYERKVPYKIVPYVY 441
LS+ L G +P+ R+ RDE +C KY W EY R VP++I+PYVY
Sbjct: 258 LSFSLPCGISSPVPYFYPIYLLILLIWRERRDEVRCAEKYKEIWAEYLRLVPWRILPYVY 317
>CE19655_2 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 412
Score = 89.7 bits (221), Expect = 8e-18
Identities = 66/256 (25%), Positives = 108/256 (41%), Gaps = 15/256 (5%)
Query: 200 WFIGRELNPRIGPLDIKMFAELRPGMLLWFLINLSCLHHSYRESGKIYDSLLLVNVLQGF 259
WF G E +P+I +D+K F R ++W L +S ++ G+I SL+ ++ +Q
Sbjct: 158 WF-GIENHPKILDIDLKSFIRTRFTFVIWPLFVISAMYFHKITYGQISTSLVCLSSVQLL 216
Query: 260 YIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYCLQARYLAVSPIEFGLPHSTL 319
YIF NE+ L +D FGF + D L P Y L + G+ + L
Sbjct: 217 YIFQFHWNEDLFLNSLDSKRCDFGFYRIWADFVLGPIIYTSPVTILVATNRSVGVISNCL 276
Query: 320 IVIIMLLGYWIFHSANKQKSDFRQGK-------------LPQLKSIQTDKGTKLLCDS-W 365
+ + ++QK +FR+ K + ++ D T LL S
Sbjct: 277 FCAVAIGSMVFTAKCDRQKYEFRKSKGTLKVGGVDAFFISAKYRTDSGDANTNLLLGSGH 336
Query: 366 WAVSQHINYFGDLLISLSWCLATGFQTPLTXXXXXXXXXXXXHRQSRDEEKCRNKYGVFW 425
W V +H NY + + ++ GF + + R DE +C KYG +W
Sbjct: 337 WGVCRHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAFTDENRCLIKYGQYW 396
Query: 426 EEYERKVPYKIVPYVY 441
+Y KV Y+ +P V+
Sbjct: 397 AQYCSKVKYRFLPGVF 412
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.325 0.143 0.456
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,578,347
Number of Sequences: 60738
Number of extensions: 1114648
Number of successful extensions: 2739
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2692
Number of HSP's gapped (non-prelim): 16
length of query: 441
length of database: 30,389,216
effective HSP length: 109
effective length of query: 332
effective length of database: 23,768,774
effective search space: 7891232968
effective search space used: 7891232968
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)