ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3059 good R KOG0725 General function prediction only Reductases with broad range of substrate specificities
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3059 1077786 1078562 259
(259 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL055c [R] KOG0725 Reductases with broad range of substrate spe... 147 1e-35
SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate ... 77 2e-14
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 69 5e-12
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 68 1e-11
7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 67 2e-11
Hs15277342 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 67 3e-11
Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 67 3e-11
CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 67 3e-11
7292613 [Q] KOG1205 Predicted dehydrogenase 65 1e-10
7296706_2 [R] KOG0725 Reductases with broad range of substrate s... 65 1e-10
CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 64 2e-10
At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP... 64 2e-10
At5g18210 [R] KOG0725 Reductases with broad range of substrate s... 64 3e-10
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 63 5e-10
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 61 2e-09
Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydrox... 60 3e-09
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 60 4e-09
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 59 7e-09
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 59 9e-09
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 58 1e-08
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 58 2e-08
CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 57 2e-08
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 57 3e-08
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 56 6e-08
7296704 [R] KOG0725 Reductases with broad range of substrate spe... 56 6e-08
7294452 [Q] KOG1205 Predicted dehydrogenase 56 6e-08
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 55 8e-08
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 55 8e-08
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 55 8e-08
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 55 1e-07
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 55 1e-07
At5g53100 [Q] KOG1208 Dehydrogenases with different specificitie... 55 1e-07
At5g50690 [Q] KOG1205 Predicted dehydrogenase 55 1e-07
At5g50590 [Q] KOG1205 Predicted dehydrogenase 55 1e-07
At3g03980 [R] KOG0725 Reductases with broad range of substrate s... 55 1e-07
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 55 1e-07
At4g24050 [Q] KOG1208 Dehydrogenases with different specificitie... 55 1e-07
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 54 2e-07
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 54 2e-07
Hs10337605 [R] KOG0725 Reductases with broad range of substrate ... 54 2e-07
At3g47360 [Q] KOG1205 Predicted dehydrogenase 54 2e-07
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 2e-07
7292690 [Q] KOG1205 Predicted dehydrogenase 54 2e-07
7297069 [Q] KOG1205 Predicted dehydrogenase 54 3e-07
YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 53 4e-07
7304181 [Q] KOG1208 Dehydrogenases with different specificities ... 53 5e-07
At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase a... 53 5e-07
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 52 6e-07
7301818 [Q] KOG1205 Predicted dehydrogenase 52 6e-07
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 52 8e-07
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 52 8e-07
Hs5031737 [R] KOG0725 Reductases with broad range of substrate s... 52 1e-06
At5g50130 [Q] KOG1208 Dehydrogenases with different specificitie... 51 1e-06
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 51 2e-06
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 50 2e-06
YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 50 3e-06
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 50 3e-06
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 50 3e-06
CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 50 4e-06
At3g47350 [Q] KOG1205 Predicted dehydrogenase 50 4e-06
Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 49 5e-06
Hs13236542 [Q] KOG1205 Predicted dehydrogenase 49 5e-06
CE06157 [R] KOG1611 Predicted short chain-type dehydrogenase 49 5e-06
7304177 [Q] KOG1208 Dehydrogenases with different specificities ... 49 5e-06
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 49 7e-06
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 49 7e-06
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 49 9e-06
CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase 49 9e-06
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 49 9e-06
>YKL055c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 147 bits (371), Expect = 1e-35
Identities = 94/253 (37%), Positives = 149/253 (58%), Gaps = 26/253 (10%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGIS----- 60
V+IV+GATRGIG I +L G S I +GS +S+ R ++ GQ G+S
Sbjct: 6 VAIVTGATRGIGKAICQKLFQKGLSCIILGSTKESI----ERTAIDRGQLQSGLSYQRQC 61
Query: 61 ---INFKGWPTWVD-TTWSQFICRNGKIETKIESNDLMAGFDK-----KQYRLDLLVNCA 111
I+FK WP W+D ++ + K + + L +K ++Y ++LL+NCA
Sbjct: 62 AIAIDFKKWPHWLDYESYDGIEYFKDRPPLKQKYSTLFDPCNKWSNNERRYYVNLLINCA 121
Query: 112 GITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTK----LHGH--RGKIVNI 165
G+TQ + +++ +++ DIMNVNFMS V++T + +K M+++ + L G R IVNI
Sbjct: 122 GLTQESLSVRTTASQIQDIMNVNFMSPVTMTNICIKYMMKSQRRWPELSGQSARPTIVNI 181
Query: 166 ASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKT 225
+S+L S + VPGT++YSASKAA+ ++ VL+ E++ +I TISPGLV+ TDMI+
Sbjct: 182 SSIL--HSGKMKVPGTSVYSASKAALSRFTEVLAAEMEPRNIRCFTISPGLVKGTDMIQN 239
Query: 226 LDPEIQQKLREKL 238
L E ++ L +
Sbjct: 240 LPVEAKEMLERTI 252
>SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 236
Score = 77.0 bits (188), Expect = 2e-14
Identities = 47/149 (31%), Positives = 85/149 (56%), Gaps = 9/149 (6%)
Query: 104 LDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIV 163
+D +V+ AG+ Q++ ++ + E+ I+ N +S++ L+++A+ + RN R I+
Sbjct: 76 IDTVVHAAGVLQSSLCVRTSEKEIDSIICTNLVSAIKLSKMAILEWFRNKNSERDR-LIL 134
Query: 164 NIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMI 223
NI+S L S +PGT++Y+ASKA + + +VL+ E+ I V ISPG V++
Sbjct: 135 NISSRL----STYALPGTSVYAASKAGLESFTKVLAAEVASKGIRVNAISPGYVDT---- 186
Query: 224 KTLDPEIQQKLREKLPNGELTSVNGIIAA 252
L +I+ +K+P G L S + I+ A
Sbjct: 187 PMLSSQIRAIAEKKVPIGRLASTDEIVDA 215
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 69.3 bits (168), Expect = 5e-12
Identities = 67/261 (25%), Positives = 114/261 (43%), Gaps = 48/261 (18%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V ++SG+++GIG + G ++ G + D V K + + + K
Sbjct: 10 VVLISGSSKGIGQATAVKFAAEGAKIVLNGRSADDVEKTRKLC----------MEVGAKP 59
Query: 66 W---PTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKA 122
W PT D T F+ K+ N ++ F K LD+L+N AG + K
Sbjct: 60 WDLLPTVGDITNEDFV--------KMMVNTVIHNFGK----LDILINNAGTLEVDMTGKE 107
Query: 123 NTNEMADIM----NVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIV 178
D+M N NF S + LTQ A+ +I+ +G IVN+++ L SS I V
Sbjct: 108 GWEMGVDVMDRSWNSNFKSVLMLTQAAMPHLIKT------KGDIVNVSTFL--SSGPIGV 159
Query: 179 PGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVEST----------DMIKTLDP 228
Y+ KAA+ Q +R ++ E + + T++PGLV ++ D + ++
Sbjct: 160 MSMPYYAVPKAALDQMSRSMAHEYMLKGVRLNTVNPGLVSTSFFARLPGVGDDNARKMEN 219
Query: 229 EIQQKLREKLPNGELTSVNGI 249
+Q K E +P G + + +
Sbjct: 220 YVQSK-TEYIPLGRVCQASDV 239
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/212 (26%), Positives = 97/212 (45%), Gaps = 31/212 (14%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V IV+GA+ GIG+ L G + +G N D + + +I G A ++ +
Sbjct: 8 VIIVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAAD--- 64
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
I ++ + +++ K R+D+LVN AGI + + +
Sbjct: 65 ------------------INSESDVQGIVSATLAKHGRIDVLVNNAGILELGSIENTSLE 106
Query: 126 EMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYS 185
+ +MN N S LT L ++I+ +G IVN++SV G S PG Y+
Sbjct: 107 QFDRVMNTNVRSLYQLTHLVTPELIKT------KGNIVNVSSVNGIRS----FPGVLAYN 156
Query: 186 ASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
SKAA+ Q+ R ++ EL + V +++PG++
Sbjct: 157 VSKAAVDQFTRCVALELAPKGVRVNSVNPGVI 188
>7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 255
Score = 67.4 bits (163), Expect = 2e-11
Identities = 72/246 (29%), Positives = 104/246 (42%), Gaps = 37/246 (15%)
Query: 1 MKQNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGIS 60
M +N VS+V+G G+G + L G SVI + + P K N G
Sbjct: 1 MIKNAVSLVTGGASGLGRATAERLAKQGASVI---------LADLPSSKGNEVAKELGDK 51
Query: 61 INFKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAI 120
+ F VD T K S L DK RLDL VNCAG
Sbjct: 52 VVFVP----VDVT-----------SEKDVSAALQTAKDKFG-RLDLTVNCAGTATAVKTF 95
Query: 121 KANTN------EMADIMNVNFMSSVSLTQLALKQMIRNT-KLHGHRGKIVNIASVLGDSS 173
N N + ++N+N + + ++ +L+ M N G RG IVN ASV
Sbjct: 96 NFNKNVAHRLEDFQRVININTVGTFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDG 155
Query: 174 SNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTLDPEIQQK 233
G A YSASKAA++ ++ +L I + TI+PGL +T M+ L +++
Sbjct: 156 QI----GQAAYSASKAAVVGMTLPIARDLSTQGIRICTIAPGLF-NTPMLAALPEKVRTF 210
Query: 234 LREKLP 239
L + +P
Sbjct: 211 LAKSIP 216
>Hs15277342 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 261
Score = 67.0 bits (162), Expect = 3e-11
Identities = 41/138 (29%), Positives = 74/138 (52%), Gaps = 9/138 (6%)
Query: 106 LLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNI 165
++V+CAGITQ + + ++ ++ VN + +TQ A + ++ N G RG I+NI
Sbjct: 99 VVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSN----GCRGSIINI 154
Query: 166 ASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKT 225
+S++G + G Y+ASKA +I + + EL R I ++ PG + +T M +
Sbjct: 155 SSIVGKVGN----VGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFI-ATPMTQK 209
Query: 226 LDPEIQQKLREKLPNGEL 243
+ ++ K+ E +P G L
Sbjct: 210 VPQKVVDKITEMIPMGHL 227
>Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 179
Score = 66.6 bits (161), Expect = 3e-11
Identities = 49/210 (23%), Positives = 93/210 (43%), Gaps = 34/210 (16%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V V G +RGIG + + GY + I N + + +H F+ ++
Sbjct: 4 VCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVA----- 58
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
+ ++ E + G R++ LVN AGI + ++ T
Sbjct: 59 --------------KEHDVQNTFEEMEKHLG------RVNFLVNAAGINRDGLLVRTKTE 98
Query: 126 EMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYS 185
+M ++ N + S+ + A++ MI+ G IVN+ S++G ++ G ++YS
Sbjct: 99 DMVSQLHTNLLGSMLTCKAAMRTMIQQ-----QGGSIVNVGSIVGLKGNS----GQSVYS 149
Query: 186 ASKAAMIQYNRVLSEELKRLSIDVQTISPG 215
ASK ++ ++R L++E+ R I V ++PG
Sbjct: 150 ASKGGLVGFSRALAKEVARKKIRVNVVAPG 179
>CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 296
Score = 66.6 bits (161), Expect = 3e-11
Identities = 42/148 (28%), Positives = 75/148 (50%), Gaps = 9/148 (6%)
Query: 106 LLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNI 165
+LVNCAGIT+ +K + N+ D+MNVN S ++Q+ + R + G IVN+
Sbjct: 134 VLVNCAGITKDATLLKMSQNQWQDVMNVNLNSVFLMSQM----IARESVAAGSPLSIVNV 189
Query: 166 ASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKT 225
+S++G + G Y+A+K+ +I + + + EL +I V + PG + T M +
Sbjct: 190 SSIVGKIGNF----GQTNYAATKSGVIGFTKSAARELATKNIRVNAVLPGFIR-TPMTEA 244
Query: 226 LDPEIQQKLREKLPNGELTSVNGIIAAM 253
+ P++ + +P L I A+
Sbjct: 245 MPPKVLDAMVSMVPQRRLGETEEIANAV 272
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 65.1 bits (157), Expect = 1e-10
Identities = 63/245 (25%), Positives = 111/245 (44%), Gaps = 34/245 (13%)
Query: 3 QNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISIN 62
QN V++V+GA+ GIGS I +L+L+G +V+ + D V + Q +
Sbjct: 5 QNRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQREL-------------- 50
Query: 63 FKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKA 122
P C G + E+ D + +K +D+LVN AG Q +
Sbjct: 51 ----PAEKRGKLFALYCDVGNESSVNEAFDWII---QKLGAIDVLVNNAGTLQPGYLVDM 103
Query: 123 NTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGD---SSSNIIVP 179
N M ++ N M V TQ A++ M R K GH +V I S+LG +++ + P
Sbjct: 104 NPAVMQQVLQTNIMGIVLCTQRAVRSM-RERKFDGH---VVLINSILGHKTMTATEGVAP 159
Query: 180 GTAMYSASKAAMIQYNRVLSEELKRLS--IDVQTISPGLVESTDMIKTLDPEIQQKLREK 237
+Y SK A+ +E L I + ++SPG+V++ + + I++ ++++
Sbjct: 160 DVNVYPPSKHAVTALAEGYRQEFFGLGTRIKITSVSPGVVDT----EIVPDSIREAIKDR 215
Query: 238 LPNGE 242
+ + E
Sbjct: 216 MLHSE 220
>7296706_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 233
Score = 65.1 bits (157), Expect = 1e-10
Identities = 49/140 (35%), Positives = 76/140 (54%), Gaps = 15/140 (10%)
Query: 100 KQYRLDLLVNCAGITQTTAAIKANTNEMAD-IMNVNFMSSVSLTQLALKQMIRNTKLHGH 158
K R+D+LVN AGI + T +I+A + E D +MN N S LT LA ++++
Sbjct: 57 KHGRIDVLVNNAGILE-TGSIEATSLEQFDRLMNTNVRSLYQLTMLATPELVKT------ 109
Query: 159 RGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVE 218
+G IVN++SV G + PG Y+ SKAA+ Q+ ++ EL + V ++PG++
Sbjct: 110 KGNIVNVSSVCGLRA----FPGVLAYNVSKAAVDQFTACIALELAPKGVRVNAVNPGVI- 164
Query: 219 STDMIKT--LDPEIQQKLRE 236
TD+ K +D E K E
Sbjct: 165 VTDIHKRGGMDEETYAKFLE 184
>CE04339 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 255
Score = 64.3 bits (155), Expect = 2e-10
Identities = 35/138 (25%), Positives = 74/138 (53%), Gaps = 8/138 (5%)
Query: 106 LLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNI 165
+LVNCAGIT+ + +K + ++ VN ++Q +K + N + H I+N+
Sbjct: 92 ILVNCAGITKDSTLLKMKQEQWDSVIKVNLTGVFHVSQAFVKASVDN---NNHPLSIINV 148
Query: 166 ASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKT 225
+S++G + G Y+A+KA +I + + ++EL + ++ V + PG ++ T M +
Sbjct: 149 SSIVGKMGNF----GQTNYAATKAGVIGFTKSAAKELAKKNVRVNAVLPGFIK-TPMTEA 203
Query: 226 LDPEIQQKLREKLPNGEL 243
+ P + ++ + +P G +
Sbjct: 204 MPPTVLAEICKGIPMGRM 221
>At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 308
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/257 (24%), Positives = 112/257 (43%), Gaps = 45/257 (17%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V +++GA+RGIG I + +G V+ N R + AK I
Sbjct: 78 VVVITGASRGIGKAI----------ALALGKAGCKVLVNYARSAKEAEEVAKQI------ 121
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
+ Q I G + + + +M K +D++VN AGIT+ T I+ +
Sbjct: 122 -----EEYGGQAITFGGDVSKATDVDAMMKTALDKWGTIDVVVNNAGITRDTLLIRMKQS 176
Query: 126 EMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYS 185
+ +++ +N TQ G+I+NI+SV+G NI G A Y+
Sbjct: 177 QWDEVIALNLTGVFLCTQ----------------GRIINISSVVG-LIGNI---GQANYA 216
Query: 186 ASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTLDPEIQQKLREKLP---NGE 242
A+K +I +++ + E +I+V + PG + S DM L ++++K+ +P G+
Sbjct: 217 AAKGGVISFSKTAAREGASRNINVNVVCPGFIAS-DMTAELGEDMEKKILGTIPLGRYGK 275
Query: 243 LTSVNGIIAAMGLKNLA 259
V G++ + L A
Sbjct: 276 AEEVAGLVEFLALSPAA 292
>At5g18210 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 63.5 bits (153), Expect = 3e-10
Identities = 66/251 (26%), Positives = 108/251 (42%), Gaps = 26/251 (10%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V+IV+G++RGIG I I++ +V N Q A I+ +
Sbjct: 12 VAIVTGSSRGIGRAI----------AIHLAELGAKIVINYTTRSTEADQVAAEINSSAGT 61
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANT- 124
P + + I +I++ ++ + F+ + +LVN AGI ANT
Sbjct: 62 VPQPIAVVFLADISEPSQIKSLFDAAE--KAFNSPVH---ILVNSAGILNPNYPTIANTP 116
Query: 125 -NEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAM 183
E I VN S + A K++ R G G+I+ + S L ++ ++PG
Sbjct: 117 IEEFDRIFKVNTRGSFLCCKEAAKRLKR-----GGGGRIILLTSSLTEA----LIPGQGA 167
Query: 184 YSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTLDPEIQQKLREKLPNGEL 243
Y+ASKAA+ ++L++ELK L I +SPG V + E + E+ P G L
Sbjct: 168 YTASKAAVEAMVKILAKELKGLGITANCVSPGPVATEMFFDGKSEETVMNIIERSPFGRL 227
Query: 244 TSVNGIIAAMG 254
I + +G
Sbjct: 228 GETKDIASVVG 238
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 62.8 bits (151), Expect = 5e-10
Identities = 60/251 (23%), Positives = 111/251 (43%), Gaps = 36/251 (14%)
Query: 7 SIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKGW 66
++V+G+T GIG +EL G V+ I + D + + IK + I+++F
Sbjct: 53 AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFAS- 111
Query: 67 PTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTNE 126
+ + + +E I N++ ++ +Y LD + N
Sbjct: 112 ----EDIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLD--------------VPDLDNV 153
Query: 127 MADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYSA 186
+ ++N+N +S +TQL L M+ +K G I+NI+S S + VP +YSA
Sbjct: 154 IKKMININILSVCKMTQLVLPGMVERSK-----GAILNISS----GSGMLPVPLLTIYSA 204
Query: 187 SKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTLDPEIQQKLREKLPNGELTSV 246
+K + +++ L EE + + VQ++ P V +T + K P + + E T V
Sbjct: 205 TKTFVDFFSQCLHEEYRSKGVFVQSVLPYFV-ATKLAKIRKPTLDKPSPE-------TFV 256
Query: 247 NGIIAAMGLKN 257
I +GL++
Sbjct: 257 KSAIKTVGLQS 267
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 60.8 bits (146), Expect = 2e-09
Identities = 59/214 (27%), Positives = 96/214 (44%), Gaps = 32/214 (14%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V++V+G++ GIG L G V G N + + + I G+ +
Sbjct: 8 VALVTGSSNGIGRATAILLAREGAKVTITGRNAQRLEETKQEI------LRSGVPEDH-- 59
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAG--ITQTTAAIKAN 123
V + + +G+IE + D+ RLD+LVN AG IT I
Sbjct: 60 ----VLSIIADLATESGQIELMNSTVDIFG-------RLDILVNNAGAAITDLEGHIGVG 108
Query: 124 TNEMA--DIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGT 181
TN M +N S V+LTQ A + +I+ +G+IVN++S+ G + P
Sbjct: 109 TNVSVFDKTMRINLRSVVTLTQKAKEHLIKT------KGEIVNVSSIAGGQHAQ---PEL 159
Query: 182 AMYSASKAAMIQYNRVLSEELKRLSIDVQTISPG 215
Y+ SK+A+ QY R + +L + + V ++SPG
Sbjct: 160 IYYAMSKSALDQYTRSAAIDLIQHGVRVNSVSPG 193
>Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 261
Score = 60.1 bits (144), Expect = 3e-09
Identities = 45/144 (31%), Positives = 75/144 (51%), Gaps = 12/144 (8%)
Query: 103 RLDLLVNCAGI---TQTTAAIKANTNEMAD---IMNVNFMSSVSLTQLALKQMIRNTKLH 156
R+D+ VNCAGI ++T K T+ + D +++VN M + ++ +L +M +N
Sbjct: 84 RVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQ 143
Query: 157 G-HRGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPG 215
G RG I+N ASV G A YSASK ++ ++ +L + I V TI+PG
Sbjct: 144 GGQRGVIINTASVAAFEGQ----VGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPG 199
Query: 216 LVESTDMIKTLDPEIQQKLREKLP 239
L T ++ +L ++ L ++P
Sbjct: 200 LF-GTPLLTSLPEKVCNFLASQVP 222
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 59.7 bits (143), Expect = 4e-09
Identities = 39/129 (30%), Positives = 70/129 (54%), Gaps = 13/129 (10%)
Query: 91 NDLMAGFDKKQYRLDLLVNCAGIT----QTTAAIKANTNEMADIMNVNFMSSVSLTQLAL 146
++L+ +K RLD+LVN AG Q + + + IM +N S V+LTQ A
Sbjct: 75 DELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIMQINMRSVVTLTQKAK 134
Query: 147 KQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLS 206
+ +++ +G+IVN++S+ G + + PG Y+ SK+A+ Q+ R + +L +
Sbjct: 135 EHLVKA------KGEIVNVSSIAGTAHAQ---PGVMYYAMSKSALDQFTRCAAIDLIQYG 185
Query: 207 IDVQTISPG 215
+ V ++SPG
Sbjct: 186 VRVNSVSPG 194
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 58.9 bits (141), Expect = 7e-09
Identities = 53/217 (24%), Positives = 96/217 (43%), Gaps = 25/217 (11%)
Query: 3 QNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISIN 62
+N V +++GAT G+G + +G ++ G N ++ + + +H +
Sbjct: 51 RNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQ----T 106
Query: 63 FKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKA 122
K + D T S I + +++ F +D+LVN AGI+ +
Sbjct: 107 HKPYLVTFDLTDSGAIVA--------AAAEILQCFGY----VDILVNNAGISYRGTIMDT 154
Query: 123 NTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTA 182
+ +M N+ V+LT+ L MI+ +G IV I+S+ G S +P +
Sbjct: 155 TVDVDKRVMETNYFGPVALTKALLPSMIKR-----RQGHIVAISSIQGKMS----IPFRS 205
Query: 183 MYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
Y+ASK A + L E+++ I+V ISPG + +
Sbjct: 206 AYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHT 242
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 58.5 bits (140), Expect = 9e-09
Identities = 50/212 (23%), Positives = 90/212 (41%), Gaps = 36/212 (16%)
Query: 4 NLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINF 63
N V IV+GA+ GIG+ I L G ++ +G N ++ + +K + ++
Sbjct: 5 NKVVIVTGASSGIGAAIAQVLAREGATLALVGRNVANLEATKKSLKGTQAEIV--VADVT 62
Query: 64 KGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKAN 123
K V T ++F R+D+LVN AGI I +
Sbjct: 63 KDADAIVQQTLAKF------------------------GRIDVLVNNAGILGKGGLIDLD 98
Query: 124 TNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAM 183
E ++N N + LT+ L +++ +G +VN++S G G
Sbjct: 99 IEEFDAVLNTNLRGVILLTKAVLPHLLKT------KGAVVNVSSCAGIRP----FAGALS 148
Query: 184 YSASKAAMIQYNRVLSEELKRLSIDVQTISPG 215
Y SKAA+ Q+ ++++ E+ + V +++PG
Sbjct: 149 YGVSKAALDQFTKIVALEMAPQGVRVNSVNPG 180
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 58.2 bits (139), Expect = 1e-08
Identities = 55/216 (25%), Positives = 96/216 (43%), Gaps = 32/216 (14%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V++V+G++ GIG L G V G N D + + + I + +SI
Sbjct: 8 VALVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQEILKSGVPEDHVLSIATD- 66
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGIT----QTTAAIK 121
+ T+ ++L+ +K RLD+LVN AG Q +
Sbjct: 67 ------------------LATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVD 108
Query: 122 ANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGT 181
+ + IM +N S V+LTQ A + +++ +G++VN++S+ + P
Sbjct: 109 QDVSVYDRIMQINMRSVVTLTQKAKEHLVKA------KGEVVNVSSIGAGPQAQ---PTF 159
Query: 182 AMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
Y+ SKAA+ QY R + +L + + V ++SPG V
Sbjct: 160 MYYAMSKAALDQYTRSAAIDLIQYGVRVNSVSPGAV 195
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/137 (29%), Positives = 74/137 (53%), Gaps = 11/137 (8%)
Query: 99 KKQYRLDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTK--LH 156
KK ++D+L+N AG + NT++ D+ + F + A+ +M++ TK L
Sbjct: 82 KKFGKIDILINNAGANVVDGTV--NTDQSIDLYHKTFQINFQ----AVVEMVKKTKKYLI 135
Query: 157 GHRGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGL 216
+G+IVN++S+ + + P Y+A+KAA+ QY R ++ +L + + V ++SPG+
Sbjct: 136 ESKGEIVNVSSIAAGPQAVSMSP---YYAAAKAALNQYTRCVALDLIKQGVRVNSVSPGI 192
Query: 217 VESTDMIKTLDPEIQQK 233
+ + M PE QK
Sbjct: 193 IATNFMGAMGVPEQAQK 209
>CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 258
Score = 57.4 bits (137), Expect = 2e-08
Identities = 45/159 (28%), Positives = 76/159 (47%), Gaps = 15/159 (9%)
Query: 92 DLMAGFDKKQY---RLDLLVNCAGITQTTAAIKANTNEMADI------MNVNFMSSVSLT 142
++ A F K Q RLD LVNCAGI + D ++VN + + ++
Sbjct: 67 EVRAAFAKVQAEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVLGTFNVI 126
Query: 143 QLALKQMIRNTK-LHGHRGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEE 201
+ + M + K +G RG ++N ASV G + YSASK A++ L+ +
Sbjct: 127 RHGVALMGEHEKDANGQRGVVINTASVAAFDGQT----GQSAYSASKGAIVGMTLPLARD 182
Query: 202 LKRLSIDVQTISPGLVESTDMIKTLDPEIQQKLREKLPN 240
I TI+PGL++ T ++ +L +++ L + +PN
Sbjct: 183 FAGDGIRFNTIAPGLMD-TPLLSSLPEKVKSFLAQLIPN 220
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 56.6 bits (135), Expect = 3e-08
Identities = 44/157 (28%), Positives = 78/157 (49%), Gaps = 20/157 (12%)
Query: 76 QFICRNGKIETKIES----------NDLMAGFDKKQY-RLDLLVNCAGITQTTAAIKANT 124
Q I ++G E ++ S D + KQ+ ++D+LVN AG A T
Sbjct: 48 QIILKSGVSEKQVNSVVADVTTEDGQDQIINSTLKQFGKIDVLVNNAGAAIPDAFGTTGT 107
Query: 125 NEMADIMNVNFMSSVSLTQLALKQMIRNTKLH--GHRGKIVNIASVLGDSSSNIIVPGTA 182
++ DI + ++ L A+ +M + K H +G+IVN++S++ + P
Sbjct: 108 DQGIDI----YHKTLKLNLQAVIEMTKKVKPHLVASKGEIVNVSSIVAGPQAQ---PDFL 160
Query: 183 MYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
Y+ +KAA+ QY R + +L + I V ++SPG+VE+
Sbjct: 161 YYAIAKAALDQYTRSTAIDLAKFGIRVNSVSPGMVET 197
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 55.8 bits (133), Expect = 6e-08
Identities = 33/115 (28%), Positives = 58/115 (49%), Gaps = 10/115 (8%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKI 162
R+D L+N AGI + + + ++MNVN S + LT+ AL +I +G +
Sbjct: 81 RIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSLIRLTRAALPHIITT------KGTV 134
Query: 163 VNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
VN++S+ G G Y SK+A+ Q+ + L+ E+ + V + PG++
Sbjct: 135 VNVSSINGPCP----FAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVCPGVI 185
>7296704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 55.8 bits (133), Expect = 6e-08
Identities = 37/122 (30%), Positives = 62/122 (50%), Gaps = 10/122 (8%)
Query: 98 DKKQYRLDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHG 157
++ + +LD+LVN AGI T +M N S LT+L L Q+++
Sbjct: 86 ERYEGKLDVLVNGAGIMPTGTLQSTELACFTHVMEANVRSGFYLTKLLLPQLLQ------ 139
Query: 158 HRGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
+G IVN++SV G + P Y+ SKAA+ Q+ R L+ +L + V ++PG++
Sbjct: 140 CKGSIVNVSSVCGLRA----FPNLVAYNMSKAAVDQFTRSLALDLGPQGVRVNAVNPGVI 195
Query: 218 ES 219
+
Sbjct: 196 RT 197
>7294452 [Q] KOG1205 Predicted dehydrogenase
Length = 266
Score = 55.8 bits (133), Expect = 6e-08
Identities = 56/244 (22%), Positives = 106/244 (42%), Gaps = 40/244 (16%)
Query: 4 NLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINF 63
N V++VSGA+ GIG+ L+ +G V+ + + V K + + L I +
Sbjct: 20 NKVAVVSGASAGIGAACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQQSRLHAIKCDI 79
Query: 64 KGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFD---KKQYRLDLLVNCAGITQTTAAI 120
+ + ++ FD ++ +D+LV+ AGI T
Sbjct: 80 ------------------------TQEDQVLKAFDWTCRQLGGVDVLVSNAGIIGTGELS 115
Query: 121 KANTN-EMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNI--I 177
+ + M + N M +V +++ R+ K G G +V + SV G N+
Sbjct: 116 ERDDGPAMRSTIETNIMGTV----YCVRESFRSMKRRGTEGHVVIVNSVAGYQVPNLGPQ 171
Query: 178 VPGTAMYSASKAAMIQYNRVLSEELKR--LSIDVQTISPGLVESTDMIKTLDPEIQQKLR 235
+P +Y A+K A+ N + +E +R ++ V T+SPG+V++ L +IQ ++
Sbjct: 172 LPSLNIYPATKFALRAMNEIYRQEFQRHKTAVRVSTVSPGIVDTV----ILPEQIQGIIK 227
Query: 236 EKLP 239
+ +P
Sbjct: 228 QHMP 231
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 55.5 bits (132), Expect = 8e-08
Identities = 42/133 (31%), Positives = 69/133 (51%), Gaps = 10/133 (7%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKI 162
R+D+LVN G++Q + + + + ++ +N++ +VSLT+ L MI +GKI
Sbjct: 131 RIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIER-----KQGKI 185
Query: 163 VNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRL-SIDVQTISPGLVESTD 221
V + S+LG I VP + Y ASK A+ + L EL I V I PG V+S
Sbjct: 186 VTVNSILG----IISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPVQSNI 241
Query: 222 MIKTLDPEIQQKL 234
+ +L E+ + +
Sbjct: 242 VENSLAGEVTKTI 254
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 55.5 bits (132), Expect = 8e-08
Identities = 33/114 (28%), Positives = 57/114 (49%), Gaps = 10/114 (8%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKI 162
R+D L+N AGI + + + ++MNVN S + LT+ AL +I +G +
Sbjct: 81 RIDTLINSAGILRAGPVLDSGIEVYDELMNVNVRSLIRLTRAALPHIITT------KGTV 134
Query: 163 VNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGL 216
VN++S+ G P Y SK+A+ Q+ + L+ E+ + V + PG+
Sbjct: 135 VNVSSINGPCP----FPNVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVCPGV 184
Score = 49.7 bits (117), Expect = 4e-06
Identities = 30/110 (27%), Positives = 54/110 (48%), Gaps = 10/110 (9%)
Query: 108 VNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIAS 167
+N AGI + + + ++MNVN S + LT+ AL +I +G +VN++S
Sbjct: 381 INSAGILRAGPVLDSGIEVYDELMNVNVRSLIRLTRAALPHIITT------KGTVVNVSS 434
Query: 168 VLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
+ G G Y SK+A+ Q+ + L+ E+ + V + PG++
Sbjct: 435 INGPCP----FAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVCPGVI 480
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 55.5 bits (132), Expect = 8e-08
Identities = 55/220 (25%), Positives = 99/220 (45%), Gaps = 46/220 (20%)
Query: 8 IVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGIS------I 61
I++G++ GIG G V G N+D + + + +I L G A+ I+
Sbjct: 10 IITGSSNGIGRSAAVIFAKEGAQVTITGRNEDRLEETKQQI-LKAGVPAEKINAVVADVT 68
Query: 62 NFKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIK 121
G ++TT ++F GKI D+LVN AG
Sbjct: 69 EASGQDDIINTTLAKF----GKI--------------------DILVNNAGANLADGT-- 102
Query: 122 ANTNEMADI----MNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNII 177
ANT++ ++ +NF + + +TQ + +I+ +G+IVN++S++ ++
Sbjct: 103 ANTDQPVELYQKTFKLNFQAVIEMTQKTKEHLIKT------KGEIVNVSSIVAGPQAH-- 154
Query: 178 VPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
G Y+ +KAA+ QY R + +L + + V ++SPG V
Sbjct: 155 -SGYPYYACAKAALDQYTRCTAIDLIQHGVRVNSVSPGAV 193
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 55.1 bits (131), Expect = 1e-07
Identities = 58/218 (26%), Positives = 99/218 (44%), Gaps = 32/218 (14%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V+I++G++ GIG L G V G N + + + + I L G +G + G
Sbjct: 8 VAIITGSSNGIGQATARLLASEGAKVTVTGRNAERLEETK-NILLGAG-VPEGNVLVVVG 65
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
D T + ++ N + + DK ++D+LVN AG A K+ N
Sbjct: 66 -----DIT-----------QESVQENLIKSTLDKFG-KIDILVNNAGAGIPDAQGKSGVN 108
Query: 126 EMADIMN----VNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGT 181
+ D + +N S + +TQ A + + +G+IVNI+S+ ++ + P
Sbjct: 109 QSIDTYHKTFELNVQSVIEMTQKARPHLAKT------QGEIVNISSIGAGPAAQVASP-- 160
Query: 182 AMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
YS +KAA+ QY R + +L I V ++SPG V +
Sbjct: 161 -YYSIAKAALDQYTRTAAIDLVPEGIRVNSVSPGAVST 197
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 55.1 bits (131), Expect = 1e-07
Identities = 56/216 (25%), Positives = 99/216 (44%), Gaps = 32/216 (14%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V+I++G++ GIG G V G + + + + + +I A G+S
Sbjct: 8 VAIITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQI------LAAGVS----- 56
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
+ + + + T +++++ K +LD+LVN AG + K T
Sbjct: 57 -----EQNVNSVVA---DVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTA 108
Query: 126 EMAD----IMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGT 181
+ + +N+N S ++LT+ A+ L +G+IVNI+S+ +S P
Sbjct: 109 QSIESYDATLNLNLRSVIALTKKAVPH------LSSTKGEIVNISSI---ASGLHATPDF 159
Query: 182 AMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
YS +KAA+ QY R + +L + I V +ISPGLV
Sbjct: 160 PYYSIAKAAIDQYTRNTAIDLIQHGIRVNSISPGLV 195
>At5g53100 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 364
Score = 55.1 bits (131), Expect = 1e-07
Identities = 64/252 (25%), Positives = 111/252 (43%), Gaps = 41/252 (16%)
Query: 4 NLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINF 63
+L IV+G+T GIGS+ +L +G V+ N + + + + +G+ +N
Sbjct: 44 HLTCIVTGSTSGIGSETARQLAEAGAHVVMAVRNIKAAHELIQQWQTKWSASGEGLPLNI 103
Query: 64 KGWPTWVDTTWSQFICRNGKIETKIESNDLMAGF----DKKQYRLDLLVNCAGITQTTAA 119
+ +E + S D + F + + L +L+N AG+ A
Sbjct: 104 QA------------------MELDLLSLDSVVRFSNAWNARLAPLHVLINNAGMFAMGGA 145
Query: 120 IKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLG-----DSSS 174
K + + M VN ++ L+ L L +IR R +I+N+ SV+ D +
Sbjct: 146 QKFSEDGYEQHMQVNHLAPALLSLLLLPSLIR-----ASRSRIINVNSVMHYVGFVDPND 200
Query: 175 NIIVPG------TAMYSASKAAMIQYNRVLSEELK-RLSIDVQTISPGLVESTDMIKTLD 227
V G + YS+SK A + +N VL ++L I V +SPG+V+ T++ + L
Sbjct: 201 MNFVSGKRKFSSLSAYSSSKLAQVMFNNVLLKKLPLETGISVVCLSPGVVQ-TNITRDL- 258
Query: 228 PEIQQKLREKLP 239
P + Q L LP
Sbjct: 259 PRLVQDLYSALP 270
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 55.1 bits (131), Expect = 1e-07
Identities = 43/120 (35%), Positives = 64/120 (52%), Gaps = 16/120 (13%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADIM---NVNFMSSVSLTQLALKQMIRNTKLHGHR 159
RLD LVN AGI + A + +E++D++ N NF V T A+ + + +
Sbjct: 125 RLDHLVNNAGIAE--AKFFEDYSEISDVLPIVNTNFWGPVYATHFAIPHLKKT------K 176
Query: 160 GKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
GKI+ +AS G S VP ++Y+ASKAAMI + L EL + V + PGL+E+
Sbjct: 177 GKIIAVASPAGWSG----VPRMSIYAASKAAMINFYETLRIEL-HPEVGVTIVFPGLIEN 231
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 55.1 bits (131), Expect = 1e-07
Identities = 43/120 (35%), Positives = 64/120 (52%), Gaps = 16/120 (13%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADIM---NVNFMSSVSLTQLALKQMIRNTKLHGHR 159
RLD LVN AGI + A + +E++D++ N NF V T A+ + + +
Sbjct: 125 RLDHLVNNAGIAE--AKFFEDYSEISDVLPIVNTNFWGPVYATHFAIPHLKKT------K 176
Query: 160 GKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
GKI+ +AS G S VP ++Y+ASKAAMI + L EL + V + PGL+E+
Sbjct: 177 GKIIAVASPAGWSG----VPRMSIYAASKAAMINFYETLRIEL-HPEVGVTIVFPGLIEN 231
>At3g03980 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 55.1 bits (131), Expect = 1e-07
Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 28/254 (11%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V+IV+G++RGIG I L G ++ N S + R+ F I KG
Sbjct: 18 VAIVTGSSRGIGRAIAIHLAELGARIVI---NYTSKAADAERVASEINDFPVREEITGKG 74
Query: 66 WPTWVDTTWSQFICRNGKIETKI-ESNDLMAGFDKKQYRLD----LLVNCAGITQTTAAI 120
V ++ + E + + + FD + + +LVN AGI
Sbjct: 75 PRAIV-------------VQANVSEPSQVKSMFDAAESAFEAPVHILVNSAGILDPKYPT 121
Query: 121 KANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPG 180
A+T+ + + F + L K+ K G G+I+ + S S + + PG
Sbjct: 122 IADTS--VEDFDHTFSVNTKGAFLCSKEAANRLK-QGGGGRIILLTS----SQTRSLKPG 174
Query: 181 TAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTLDPEIQQKLREKLPN 240
Y+ASKAA+ ++L++ELK I ++PG + + PE+ +K+ + P
Sbjct: 175 FGAYAASKAAVETMVKILAKELKGTGITANCVAPGPIATEMFFDGKTPELVEKIAAESPF 234
Query: 241 GELTSVNGIIAAMG 254
G + ++ +G
Sbjct: 235 GRVGEAKDVVPLVG 248
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 54.7 bits (130), Expect = 1e-07
Identities = 61/242 (25%), Positives = 103/242 (42%), Gaps = 35/242 (14%)
Query: 7 SIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKGW 66
++++GA GIG EL G +V+ I + + I+ G+ K I +F
Sbjct: 51 AVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFT-- 108
Query: 67 PTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTT--AAIKANT 124
K + + +AG + + +LVN G+ +
Sbjct: 109 ----------------KDDIYEHIKEKLAGLE-----IGILVNNVGMLPNLLPSHFLNAP 147
Query: 125 NEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMY 184
+E+ +++ N S V +TQL LK M K G I+NI+S + + P +MY
Sbjct: 148 DEIQSLIHCNITSVVKMTQLILKHMESRQK-----GLILNISSGI----ALFPWPLYSMY 198
Query: 185 SASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTLDPEIQQKLREKLPNGELT 244
SASKA + +++ L EE K + +Q ++P V ST M K L+ + K ++ L
Sbjct: 199 SASKAFVCAFSKALQEEYKAKEVIIQVLTPYAV-STAMTKYLNTNVITKTADEFVKESLN 257
Query: 245 SV 246
V
Sbjct: 258 YV 259
>At4g24050 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 54.7 bits (130), Expect = 1e-07
Identities = 52/232 (22%), Positives = 101/232 (43%), Gaps = 37/232 (15%)
Query: 3 QNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISIN 62
+++ ++++GAT GIG++ L G +I+ N + + + RI +
Sbjct: 33 RSITAVITGATSGIGAETARVLAKRGARLIFPARNVKAAEEAKERIVSEFPE-------- 84
Query: 63 FKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKA 122
++ + + + + +A F+ L+LL+N AG AI
Sbjct: 85 ------------TEIVVMKLDLSSIASVRNFVADFESLDLPLNLLINNAGKLAHEHAISE 132
Query: 123 NTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIAS-VLGDSSSNII---- 177
+ EM N++ LT L L +MI+ + G +G+IVN+ S + G S ++I
Sbjct: 133 DGIEMT--FATNYLGHFLLTNLLLNKMIQTAEETGVQGRIVNVTSGIHGWFSGDLIEYLR 190
Query: 178 --------VPGTAMYSASKAAMIQYNRVLSEELKRL--SIDVQTISPGLVES 219
T Y+ SK A + + + LS L+++ ++ V + PG+V +
Sbjct: 191 LISQPKCQFDATRAYALSKLANVLHTKELSSRLQKIGANVTVNCVHPGVVRT 242
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 54.3 bits (129), Expect = 2e-07
Identities = 33/119 (27%), Positives = 66/119 (54%), Gaps = 15/119 (12%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADI----MNVNFMSSVSLTQLALKQMIRNTKLHGH 158
++D+LVN AG T +NT++ ++ +NF + V +TQ + +I+
Sbjct: 86 KIDILVNNAGALLTDGT--SNTDQAVELYQKTFKLNFQAVVEMTQKTKEYLIKT------ 137
Query: 159 RGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
+G+IVN++S++ + P + Y+ +KAA+ QY R + +L + + V ++SPG++
Sbjct: 138 KGEIVNVSSIVAGPQAQ---PASPYYACAKAALDQYTRCTAIDLIQHGVRVNSVSPGVI 193
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 54.3 bits (129), Expect = 2e-07
Identities = 54/214 (25%), Positives = 90/214 (41%), Gaps = 32/214 (14%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V++V+G++ GIG G V G N + + + + I L G A+ +
Sbjct: 223 VALVTGSSNGIGRAAALLFAQQGAKVTITGRNAERLEETRQAI-LKSGVPAENV------ 275
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGIT----QTTAAIK 121
+ + T DL+ G +K RLD+LVN AG Q I
Sbjct: 276 ------------LAIAADLATDQGQTDLINGTLQKFGRLDILVNNAGAAVNDPQGRMGID 323
Query: 122 ANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGT 181
+ +N S V+L Q A + +I+ +G+I+N++S+ G + P
Sbjct: 324 QQIEDFDKTFQINMRSVVTLVQKAKEHLIKT------KGEIINVSSIGGGPHAQ---PDM 374
Query: 182 AMYSASKAAMIQYNRVLSEELKRLSIDVQTISPG 215
Y SKAA+ Q+ R + L + + V ++SPG
Sbjct: 375 MYYGMSKAALDQFTRSTAITLIQHGVRVNSVSPG 408
>Hs10337605 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 53.9 bits (128), Expect = 2e-07
Identities = 55/237 (23%), Positives = 108/237 (45%), Gaps = 33/237 (13%)
Query: 4 NLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINF 63
N V++V+ +T GIG I L G V+ +V + ++ +G+S+
Sbjct: 14 NKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQ------GEGLSV-- 65
Query: 64 KGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKAN 123
+ +C GK E + L+A K +D+LV+ A + ++
Sbjct: 66 -----------TGTVCHVGKAEDR---ERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDV 111
Query: 124 TNEMAD-IMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTA 182
T E+ D +++N + +T+ + +M + G +V ++S+ S S PG +
Sbjct: 112 TEEVWDKTLDINVKAPALMTKAVVPEMEKRGG-----GSVVIVSSIAAFSPS----PGFS 162
Query: 183 MYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVE-STDMIKTLDPEIQQKLREKL 238
Y+ SK A++ + L+ EL +I V ++PGL++ S + +D E ++ ++E L
Sbjct: 163 PYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 219
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 53.9 bits (128), Expect = 2e-07
Identities = 42/121 (34%), Positives = 68/121 (55%), Gaps = 13/121 (10%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMAD-IMNVNFMSSVSLTQLALKQMIRNTKLHGHRGK 161
+LD L+N AG+ QT + A+ IM++NF + +T A+ + ++ +GK
Sbjct: 125 KLDHLINNAGVFQTVLFEDFTQIQDANPIMDINFWGTTYITYFAIPHLRKS------KGK 178
Query: 162 IVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTD 221
IV I S S+NI +P ++Y+ASKAA++++ L EL I + + PG+V STD
Sbjct: 179 IVAITS----GSANIPLPLASIYAASKAALLRFFETLRIELSP-DIKITIVLPGVV-STD 232
Query: 222 M 222
M
Sbjct: 233 M 233
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 53.9 bits (128), Expect = 2e-07
Identities = 54/213 (25%), Positives = 94/213 (43%), Gaps = 33/213 (15%)
Query: 7 SIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKGW 66
++V+GAT GIG + EL G +++ I + ++ I+ + K I+ +F
Sbjct: 73 AVVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAADF--- 129
Query: 67 PTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGI--TQTTAAIKANT 124
+ ++ +IE +AG D + +LVN G+ + +
Sbjct: 130 ------------AKGREVYDQIEKE--LAGID-----VGILVNNVGMMYEHPESLDLVSE 170
Query: 125 NEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMY 184
+ + +++ VN S LT+ L QMI K G IVN LG SS +P +Y
Sbjct: 171 DLLWNLLTVNMGSVTMLTRKILPQMIGRRK-----GAIVN----LGSSSELQPLPNMTVY 221
Query: 185 SASKAAMIQYNRVLSEELKRLSIDVQTISPGLV 217
+ASK + +++ L E+ +I VQ + P V
Sbjct: 222 AASKKFVTYFSKALELEVAEHNIHVQLVMPNFV 254
>7292690 [Q] KOG1205 Predicted dehydrogenase
Length = 251
Score = 53.9 bits (128), Expect = 2e-07
Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 28/220 (12%)
Query: 4 NLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINF 63
N V++V+GA+ GIG+ +L+ G V+ + +D + + + + +
Sbjct: 6 NRVAVVTGASSGIGAACCKDLVSKGLVVVGLARREDRLQELKASLPADQA---------- 55
Query: 64 KGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAI--K 121
S+F R + + E D A D D+LVN AGI + I +
Sbjct: 56 -----------SRFHGRKCDVSQEQEVIDAFAWIDATLGGADVLVNNAGIVRLGVGITHE 104
Query: 122 ANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGT 181
N ++ I++ N + T+ A K + R GH I+ + SV G N
Sbjct: 105 GNGADLRAILDTNVLGVSWCTREAFKSLKRRNVNDGH---ILIVNSVAGHRVINNPGITM 161
Query: 182 AMYSASKAAMIQYNRVLSEEL--KRLSIDVQTISPGLVES 219
MYS SK A+ VL +E + + +ISPG V++
Sbjct: 162 GMYSPSKYAVTALTEVLRQEFHNNKTQTKITSISPGAVDT 201
>7297069 [Q] KOG1205 Predicted dehydrogenase
Length = 246
Score = 53.5 bits (127), Expect = 3e-07
Identities = 50/222 (22%), Positives = 97/222 (43%), Gaps = 30/222 (13%)
Query: 3 QNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISIN 62
QN +++V+GA+ GIG+ ++ +G V+ + + + ++K + + N
Sbjct: 5 QNKLAVVTGASGGIGAACARAMIGAGLRVV-------GLARREAKLKELRESLPRELQAN 57
Query: 63 FKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAI-K 121
FI R + + + +++ D+L+N AGIT+ T +
Sbjct: 58 --------------FIPRRCDVSKEDQVQSSFDWIERELEGADVLLNNAGITRETELVTP 103
Query: 122 ANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNII--VP 179
+NT ++ ++++ N M + T ++ N K G G ++ I S+ G N I +P
Sbjct: 104 SNTQKLKEVIDTNVMGVIWCT----REAFNNMKRRGGEGHVLIINSIAGHQVLNFIDVLP 159
Query: 180 GTAMYSASKAAMIQYNRVLSEELKRLS--IDVQTISPGLVES 219
+Y A+K A+ +E + S I V I PG V +
Sbjct: 160 SFNIYPATKFAITAITETYRQEFQLHSNKIRVTGICPGAVNT 201
>YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 308
Score = 53.1 bits (126), Expect = 4e-07
Identities = 45/235 (19%), Positives = 93/235 (39%), Gaps = 43/235 (18%)
Query: 1 MKQNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGIS 60
+ +N ++++G + G+G ++ EL + K I
Sbjct: 35 LSKNATALITGGSSGLGFELAKEL---------------------------SRRINKVIV 67
Query: 61 INFKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAI 120
+ + +PT+ ++ I + E +L ++ +++++N AG+
Sbjct: 68 ADIQSFPTFAQVEYNNIFYYQCDITSLDEIKNLKKAIERDHGNINIIINNAGVAHIKKLE 127
Query: 121 KANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPG 180
E+ ++++N + + + + MI N G I+NIASVLG+ +
Sbjct: 128 HMTNKEVEQLIDINLIGAYRIISTFAEDMIDN-----REGFIINIASVLGE----LTPAR 178
Query: 181 TAMYSASKAAMIQYNRVLSEELKRLS-------IDVQTISPGLVESTDMIKTLDP 228
Y ASK AMI +++ +S + LS I + PG +++ I P
Sbjct: 179 LTSYGASKGAMIGFHKCMSRHFRSLSTECNKTGIKTLLVCPGKIKTNMFIDVPTP 233
>7304181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 331
Score = 52.8 bits (125), Expect = 5e-07
Identities = 53/227 (23%), Positives = 99/227 (43%), Gaps = 36/227 (15%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V IV+GA GIG + E+ G +V N + + I L
Sbjct: 47 VFIVTGANTGIGKETVREIAKRGGTVYMACRNLKKCEEAREEIVL--------------- 91
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
+T CR + ++ +A F ++Q L +L+N AG+ + ++ ++
Sbjct: 92 -----ETKNKYVYCRQCDLASQESIRHFVAAFKREQEHLHVLINNAGVMRCPRSLTSDGI 146
Query: 126 EMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASV--------LGDSSSNII 177
E+ + VN M LT L L + +++ +IVN++S+ GD +S+
Sbjct: 147 ELQ--LGVNHMGHFLLTNLLLDLLKKSSP-----SRIVNVSSLAHTRGEINTGDLNSDKS 199
Query: 178 VPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIK 224
YS SK A + + R L++ L+ ++ + PG+V+ T++I+
Sbjct: 200 YDEGKAYSQSKLANVLFTRELAKRLEGTNVTANALHPGVVD-TEIIR 245
>At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 305
Score = 52.8 bits (125), Expect = 5e-07
Identities = 59/240 (24%), Positives = 108/240 (44%), Gaps = 32/240 (13%)
Query: 1 MKQNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGIS 60
+K L ++V+G GIG + L G V +++ + ++ + +F +G+S
Sbjct: 3 IKPGLSALVTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLS 62
Query: 61 INFKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYR---LDLLVNCAGITQTT 117
+P+ + + G DL+A FDK LD+ +N AGI+
Sbjct: 63 -----FPSAIFVKCD--VTNRG---------DLLAAFDKHLATFGTLDICINNAGISTPL 106
Query: 118 AAIKANTN---EMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSS 174
K +T+ +NV+ ++ V TQLA+K M K G I+N+ S G
Sbjct: 107 RFDKDDTDGSKSWKHTINVDLIAVVEGTQLAIKAMKAKQK----PGVIINMGSAAGLYP- 161
Query: 175 NIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTLDPEIQQKL 234
+P +Y+ASKA ++ + R L+ +R I + + P ++ TD+ + +D I + +
Sbjct: 162 ---MPVDPIYAASKAGVVLFTRSLA-YYRRQGIRINVLCPEFIK-TDLAEAIDASILESI 216
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 52.4 bits (124), Expect = 6e-07
Identities = 64/254 (25%), Positives = 120/254 (47%), Gaps = 44/254 (17%)
Query: 3 QNLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISIN 62
+ + ++V+G ++G+G + +EL + G V + + D++ ++ +L Q AKG +
Sbjct: 17 EGMTALVTGGSKGLGEAVVEELAMLGARV-HTCARDETQLQE----RLREWQ-AKGFEVT 70
Query: 63 FKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKK-QYRLDLLVNCAGITQTTAAIK 121
+C + ++ + LM Q +L++LVN AG T IK
Sbjct: 71 TS-------------VC---DVSSREQREKLMETVSSVFQGKLNILVNNAG----TGIIK 110
Query: 122 ANTNEMAD----IMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNII 177
+T A+ +M N S+ L+Q+A + K G G IV ++SV G ++
Sbjct: 111 PSTEYTAEDYSFLMATNLESAFHLSQIAHPLL----KASG-SGSIVFMSSVAG-----LV 160
Query: 178 VPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES--TDMIKTLDPEIQQKLR 235
G ++Y ASK AM Q R L+ E +I V ++ P ++ + T I + D ++++ +
Sbjct: 161 HTGASIYGASKGAMNQLGRSLACEWASDNIRVNSVCPWVITTPLTSFIFS-DEKLRKAVE 219
Query: 236 EKLPNGELTSVNGI 249
+K P G + N +
Sbjct: 220 DKTPMGRVGEANEV 233
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 52.4 bits (124), Expect = 6e-07
Identities = 36/117 (30%), Positives = 57/117 (47%), Gaps = 9/117 (7%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKI 162
++D+L+N GI+ + +M VN+ SV+LT+ L M++ G I
Sbjct: 134 QVDILINNGGISVRADVASTAVDVDLKVMVVNYFGSVALTKALLPSMVKRGS-----GHI 188
Query: 163 VNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
I+SV G +P A YSASK AM + L E+ +I+V +SPG + +
Sbjct: 189 CFISSVQG----KFAIPQRAAYSASKHAMQAFADSLRAEVANKNINVSCVSPGYIRT 241
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 52.0 bits (123), Expect = 8e-07
Identities = 37/123 (30%), Positives = 62/123 (50%), Gaps = 10/123 (8%)
Query: 104 LDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIV 163
L L+N AG + AI + +++ +M+VNF + + + Q+IR +G IV
Sbjct: 78 LHYLINNAGAPCSAPAIDLDIEDVSKVMDVNFYGVIRMNKAFQHQLIRA------KGTIV 131
Query: 164 NIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMI 223
N+ S++ S + A Y+ASKAA++ Y+ L EL + V +I G V++
Sbjct: 132 NVNSLV----SYVPFAFNAAYNASKAALLAYSNTLRIELAPFGVQVTSIMTGGVQTKIQS 187
Query: 224 KTL 226
K L
Sbjct: 188 KPL 190
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 52.0 bits (123), Expect = 8e-07
Identities = 51/218 (23%), Positives = 97/218 (44%), Gaps = 27/218 (12%)
Query: 7 SIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKGW 66
++V+G+T GIG EL G ++ I + + + I +G + I ++F G
Sbjct: 55 AVVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGG 114
Query: 67 PTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTNE 126
D + + + + + N++ + +Y LD KA+
Sbjct: 115 ----DEIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLD-------------CYKADPPF 157
Query: 127 MADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYSA 186
+ +I+ N S +T L L MI RG I+N++S G + ++ ++YS+
Sbjct: 158 LRNIVAANIHSVTHMTALFLPGMISQ-----RRGVIINVSSTAGVIPNPLL----SVYSS 208
Query: 187 SKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIK 224
+KA + +++ L E K I +Q++ PG V +T+M K
Sbjct: 209 TKAFVNKFSDDLQTEYKEHGILIQSVQPGFV-ATNMSK 245
>Hs5031737 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 51.6 bits (122), Expect = 1e-06
Identities = 54/222 (24%), Positives = 97/222 (43%), Gaps = 34/222 (15%)
Query: 4 NLVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINF 63
N V++V+G+T GIG I L G V+ +V + +++ +G+S+
Sbjct: 36 NRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQ------GEGLSV-- 87
Query: 64 KGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKAN 123
+ +C GK E + L+A + +D LV AG+ +
Sbjct: 88 -----------AGIVCHVGKAE---DREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGT 133
Query: 124 TNEMAD-IMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTA 182
+ ++ D I++VN S L L M RG ++ ++S+ ++ N +V
Sbjct: 134 SEQIWDKILSVNVKSPALLLSQLLPYM------ENRRGAVILVSSI---AAYNPVV-ALG 183
Query: 183 MYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIK 224
+Y+ SK A++ R L+ EL I V + PG+++ TD K
Sbjct: 184 VYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIK-TDFSK 224
>At5g50130 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 51.2 bits (121), Expect = 1e-06
Identities = 34/129 (26%), Positives = 66/129 (50%), Gaps = 15/129 (11%)
Query: 104 LDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIV 163
L++L+N AG+ E+ NF+ LT++ +++MI + G G+I+
Sbjct: 116 LNILINNAGVFSPNLEFSEEKIELT--FATNFLGHYLLTEMLIEKMIDTAEKSGIEGRII 173
Query: 164 NIASVLGD-------SSSNIIVP----GTAMYSASKAAMIQYNRVLSEELK--RLSIDVQ 210
N++SV+ + S ++ P GT Y+ SK A I + + LS++LK ++ +
Sbjct: 174 NLSSVIHNWVKPDCFSFPKLLHPIRYNGTRAYAQSKLATILHAKALSKQLKDRNANVTIN 233
Query: 211 TISPGLVES 219
+ PG+V++
Sbjct: 234 AVHPGIVKT 242
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 50.8 bits (120), Expect = 2e-06
Identities = 50/218 (22%), Positives = 97/218 (43%), Gaps = 32/218 (14%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V+I++G++ GIG + G V G +++ + + + + + K
Sbjct: 9 VAIITGSSSGIGRETALLFAKEGAKVTVTGRSEEKLEETKKAL----------LDAGIKE 58
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
S F+ I ++L++ KK R+++LVN AG + A + +
Sbjct: 59 ---------SNFLIVPADITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGID 109
Query: 126 EMAD----IMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGT 181
+ + +M +N S + +TQ + ++ RG+IVN++SV+ + P
Sbjct: 110 QGIETYEQVMKLNVQSVIEMTQKVRPHLAKS------RGEIVNVSSVVALKAGWTRTP-- 161
Query: 182 AMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
Y +KAA+ QY R + L I V T++PG+V++
Sbjct: 162 -YYPLAKAALDQYTRSAAIALISEGIRVNTVNPGIVQT 198
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 50.4 bits (119), Expect = 2e-06
Identities = 62/238 (26%), Positives = 105/238 (44%), Gaps = 36/238 (15%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQP---RIKLNHGQFAKGIS-- 60
V+IV+G++ GIG L G V G N + + +++ ++ + G ++
Sbjct: 9 VAIVTGSSNGIGRATAILLASEGAKVTITGRNAERLEESRQALLKVGVPSGHINSVVADV 68
Query: 61 INFKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAI 120
G +D+T +F GKI I + AG L+V+ G T T+ +
Sbjct: 69 TTGAGQDVLIDSTLKKF----GKINILINN----AG--------ALIVDPEGKTNTSTGV 112
Query: 121 KANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPG 180
+ +NF S V +TQ ++ + NT G+IVN++SV ++ P
Sbjct: 113 ET----CLKTFQLNFQSVVEMTQ-KIRPHLANT-----HGEIVNVSSVGAGPAAENRFP- 161
Query: 181 TAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES--TDMIKTLDPEIQQKLRE 236
YSA+KAA+ QY+R + +L I V + PG V + T + P+ K+ E
Sbjct: 162 --YYSAAKAALDQYSRNTAIDLIPDGIRVNIVQPGFVATGFTTAASGMSPDASAKMYE 217
>YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 900
Score = 50.1 bits (118), Expect = 3e-06
Identities = 40/132 (30%), Positives = 67/132 (50%), Gaps = 10/132 (7%)
Query: 103 RLDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKI 162
R+D+L+N AGI + + K E A +++V+ L++ A M R+ K G+I
Sbjct: 93 RVDVLINNAGILRDVSFAKMTEREFASVVDVHLTGGYKLSRAAWPYM-RSQKF----GRI 147
Query: 163 VNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDM 222
+N AS G + G A YSA+K ++ L++E + +I+V +I+P L S
Sbjct: 148 INTASPAGLFGNF----GQANYSAAKMGLVGLAETLAKEGAKYNINVNSIAP-LARSRMT 202
Query: 223 IKTLDPEIQQKL 234
L P I ++L
Sbjct: 203 ENVLPPHILKQL 214
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 50.1 bits (118), Expect = 3e-06
Identities = 44/170 (25%), Positives = 80/170 (46%), Gaps = 15/170 (8%)
Query: 75 SQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGIT----QTTAAIKANTNEMADI 130
S F+ I T + L++ +K ++++LVN AG + Q A + + +
Sbjct: 59 SNFLIVPADITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGLDQGIDTYEKV 118
Query: 131 MNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYSASKAA 190
+ +N S + +TQ + + RG+IVN++SV +++ P Y +KAA
Sbjct: 119 LKLNVQSVIEMTQKIRPHLAKT------RGEIVNVSSVAALKFAHVRNP---YYPLAKAA 169
Query: 191 MIQYNRVLSEELKRLSIDVQTISPGLVES--TDMIKTLDPEIQQKLREKL 238
+ QY R + +L I V T++PG+V + + L E QK +K+
Sbjct: 170 LDQYTRSAAIDLISQGIRVNTVNPGVVATGFHESCTGLSTEESQKFYDKV 219
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 50.1 bits (118), Expect = 3e-06
Identities = 62/246 (25%), Positives = 113/246 (45%), Gaps = 31/246 (12%)
Query: 5 LVSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFK 64
+ ++V+G ++GIG + +EL G + I+ + D++ ++ R AKG +
Sbjct: 19 MTALVTGGSKGIGEAVVEELATLG-ARIHTCARDETQLQESLR-----KWQAKGFQV--- 69
Query: 65 GWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANT 124
TT + K E +E+ + F+ K L++LVN G ++
Sbjct: 70 -------TTSVCDVSSRDKREKLMETVSTI--FEGK---LNILVNNVGTCIVKPTLQHTA 117
Query: 125 NEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMY 184
+ + M N S+ L+QLA + K G G IV I+SV S + V G ++Y
Sbjct: 118 EDFSFTMATNLESAFHLSQLAHPLL----KASG-SGSIVLISSV----SGVVHVNGASIY 168
Query: 185 SASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDMIKTL-DPEIQQKLREKLPNGEL 243
SK AM Q R L+ E +I ++ P +E+ + ++L + E ++++ + P G +
Sbjct: 169 GVSKGAMNQLGRNLACEWASDNIRTNSVCPWFIETPLVTESLSNEEFRKEVESRPPMGRV 228
Query: 244 TSVNGI 249
VN +
Sbjct: 229 GEVNEV 234
>CE26924 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 368
Score = 49.7 bits (117), Expect = 4e-06
Identities = 39/130 (30%), Positives = 66/130 (50%), Gaps = 14/130 (10%)
Query: 104 LDLLVNCAGITQTTAAIK-ANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKI 162
L +VN AGIT A + NE + N+N + T +A+K++++ RG++
Sbjct: 153 LHAVVNNAGITGKHIADDFLDINEYLKVANINLWGPIRTT-MAVKKLLKKA-----RGRV 206
Query: 163 VNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDM 222
V +AS+ + + +PG YS SK + Y V+ +EL+ I V + PG +T +
Sbjct: 207 VTVASIC----ARVGLPGLGPYSVSKYGVSAYCDVIRQELRPFGISVHVLEPGFF-NTPL 261
Query: 223 I--KTLDPEI 230
I + +D EI
Sbjct: 262 INREKIDAEI 271
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 49.7 bits (117), Expect = 4e-06
Identities = 60/225 (26%), Positives = 98/225 (42%), Gaps = 48/225 (21%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSV-VKNQPRIKLNHGQ--FAKGISIN 62
V +++GA+ GIG + E G + + D + + + +L G G N
Sbjct: 48 VVLITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQLGSGDVIIIPGDVSN 107
Query: 63 FKGWPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKA 122
+ ++D T F GK LD L+N AG+ QT I
Sbjct: 108 VEDCKKFIDETIHHF----GK--------------------LDHLINNAGVPQTV--IFE 141
Query: 123 NTNEMAD---IMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVP 179
+ ++ D IM++NF S +T A+ + ++ +GKIV I SS+ I+P
Sbjct: 142 DFTQIQDANSIMDINFWGSTYITYFAIPHLRKS------KGKIVVI------SSATAIIP 189
Query: 180 --GTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTDM 222
++YSASKAA++++ L E+ I + PG + STDM
Sbjct: 190 LQAASVYSASKAALVKFFETLRVEISP-DIKITIALPGFI-STDM 232
>Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 309
Score = 49.3 bits (116), Expect = 5e-06
Identities = 58/224 (25%), Positives = 91/224 (39%), Gaps = 49/224 (21%)
Query: 7 SIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKGW 66
++VSGAT GIG +EL G ++I I N++ + AK I+ +K
Sbjct: 49 AVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQV-----------VAKDIADTYK-- 95
Query: 67 PTWVDTTWSQFICRNGKIETKIESNDLMAGFD--------KKQYRLDLLVNCAGITQTTA 118
+ET I D +G + K + +LVN G+
Sbjct: 96 -----------------VETDIIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYP 138
Query: 119 AIKANTNE--MADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNI 176
+E + DI+NVN ++ + + L M+ K G IV I+S S
Sbjct: 139 QYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKK-----GAIVTISS----GSCCK 189
Query: 177 IVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVEST 220
P A +SASKA + ++R L E I VQ++ P V ++
Sbjct: 190 PTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVAAS 233
>Hs13236542 [Q] KOG1205 Predicted dehydrogenase
Length = 181
Score = 49.3 bits (116), Expect = 5e-06
Identities = 37/128 (28%), Positives = 62/128 (47%), Gaps = 7/128 (5%)
Query: 104 LDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIV 163
+D+ +N AG+ + + +T+ D+ NVN ++ T+ A + M GH I+
Sbjct: 12 VDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGH---II 68
Query: 164 NIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQT--ISPGLVESTD 221
NI S+ G + V T YSA+K A+ L +EL+ ++ ISPG+VE+
Sbjct: 69 NINSMSGHRVLPLSV--THFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQF 126
Query: 222 MIKTLDPE 229
K D +
Sbjct: 127 AFKLHDKD 134
>CE06157 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 255
Score = 49.3 bits (116), Expect = 5e-06
Identities = 58/229 (25%), Positives = 99/229 (42%), Gaps = 37/229 (16%)
Query: 9 VSGATRGIG-SKIRDELLLSGYSVIYIGS-NDDSVVKNQPRIKLNHGQFAKGISINFKGW 66
++GA RGIG +R+ L + G + G+ N D + Q K + + ++
Sbjct: 8 ITGANRGIGLGLVRELLKVPGVEALVAGARNIDGAKELQSLAKADARLHLIAVDVS---- 63
Query: 67 PTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKA-NTN 125
+G +E ++S + G L+LL+N AG+ ++ A N
Sbjct: 64 -------------NDGSLENSVKSVSGIVG----DRGLNLLINNAGLIESYGTTSAPNRA 106
Query: 126 EMADIMNVNFMSSVSLTQLALKQM------IRNTKLHGHRGKIVNIASVLGDSSSNIIVP 179
+ ++VN +S++ +Q L + + L R IVNI S + N+
Sbjct: 107 SVLHCIDVNAVSALLASQHFLPLLQKAASHVSGDSLTPDRAAIVNIGSDCASQALNLRGS 166
Query: 180 GTA----MYSASKAAMIQYNRVLSEELKRLSIDV--QTISPGLVESTDM 222
G + Y SK AM+ ++R ++ + KRL I V I PG V+ TDM
Sbjct: 167 GPSNSLLAYKMSKVAMLSFSRSMAADFKRLEIPVLITNIHPGWVQ-TDM 214
>7304177 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 300
Score = 49.3 bits (116), Expect = 5e-06
Identities = 53/222 (23%), Positives = 90/222 (39%), Gaps = 35/222 (15%)
Query: 6 VSIVSGATRGIGSKIRDELLLSGYSVIYIGSNDDSVVKNQPRIKLNHGQFAKGISINFKG 65
V IV+GA GIG + E+ G +Y+ D +N + A+ I
Sbjct: 16 VFIVTGANTGIGKETVLEIAKRG-GTVYMACRD-----------MNRCEKARQDIIR--- 60
Query: 66 WPTWVDTTWSQFICRNGKIETKIESNDLMAGFDKKQYRLDLLVNCAGITQTTAAIKANTN 125
+T R + + AGF K+Q +L +L+N AG+ + +
Sbjct: 61 -----ETNNQNIFSRELDLSSLESIRKFAAGFKKEQDKLHVLINNAGVMHCPRTLTKDGF 115
Query: 126 EMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIVNIASVL--------GDSSSNII 177
EM + VN M LT L L + + +IVN++S++ D +S
Sbjct: 116 EMQ--LGVNHMGHFLLTHLLLDVLKKTAP-----SRIVNVSSLVHTQGFIKTADLNSEKS 168
Query: 178 VPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
YS SK A + + R L++ L+ + ++ PG V++
Sbjct: 169 YSRIGAYSQSKLANVLFTRELAKRLEGTGVTTNSLHPGAVDT 210
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 48.9 bits (115), Expect = 7e-06
Identities = 44/151 (29%), Positives = 75/151 (49%), Gaps = 22/151 (14%)
Query: 104 LDLLVNCAGITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKIV 163
+ +LVN AG+ T+ ++ VN ++ T+ L M +N HGH IV
Sbjct: 114 VSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNN--HGH---IV 168
Query: 164 NIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSI-DVQT-------ISPG 215
+AS G ++ VP Y +SK A + +++ L++EL L I V+T ++ G
Sbjct: 169 TVASAAG----HVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTG 224
Query: 216 LVE--STDMIKTLDPEIQQKLREKLPNGELT 244
++ ST + TL+PE ++ +L +G LT
Sbjct: 225 FIKNPSTSLGPTLEPE---EVVNRLMHGILT 252
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/139 (25%), Positives = 66/139 (47%), Gaps = 14/139 (10%)
Query: 86 TKIESNDLMAGFDKKQY-RLDLLVNCAGI----TQTTAAIKANTNEMADIMNVNFMSSVS 140
T E DL+ ++ ++++L+N AG +Q K + + + +N S V
Sbjct: 68 TTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQLNLQSVVE 127
Query: 141 LTQLALKQMIRNTKLHGHRGKIVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSE 200
+ Q + + RG+IVNI+S+ ++ P + YS++KAA+ QY+R +
Sbjct: 128 MVQKVRPHLAKT------RGEIVNISSIGAGPAAQ---PASPYYSSAKAALDQYSRCAAI 178
Query: 201 ELKRLSIDVQTISPGLVES 219
+L I + + PG V +
Sbjct: 179 DLISEGIRINVVQPGFVST 197
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 48.5 bits (114), Expect = 9e-06
Identities = 31/117 (26%), Positives = 58/117 (49%), Gaps = 10/117 (8%)
Query: 104 LDLLVNCAGITQ-TTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGKI 162
+D+L+N AG+ T I N ++ ++ N + +++T+ L K G I
Sbjct: 86 IDVLINNAGLALGTDKVIDLNIDDAVTMITTNVLGMMAMTRAVLPIFYSKNK-----GDI 140
Query: 163 VNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVES 219
+N+ S+ G S G ++Y ++K+A+ Q+ L +E I + + PGLVE+
Sbjct: 141 LNVGSIAGRES----YVGGSVYCSTKSALAQFTSALRKETIDTRIRIMEVDPGLVET 193
>CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 48.5 bits (114), Expect = 9e-06
Identities = 44/129 (34%), Positives = 63/129 (48%), Gaps = 11/129 (8%)
Query: 104 LDLLVNCAG-ITQTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNT------KLH 156
L+LLVN AG K N A+ +NVN S V LTQ + +I+ + +L
Sbjct: 82 LNLLVNNAGNAVDYPCKAKPNRALFAEQLNVNTTSVVILTQKLMPLLIKASSKVSGDQLS 141
Query: 157 GHRGKIVNIASVLG---DSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTIS 213
R +V I+S L D ++ P Y SKAA+ + R L+ ++K I V +I
Sbjct: 142 ASRAAVVTISSGLASMTDFATGGHAPNAFAYRISKAAINMFGRALANDMKDDHILVASIG 201
Query: 214 PGLVESTDM 222
PG V+ TDM
Sbjct: 202 PGWVK-TDM 209
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 48.5 bits (114), Expect = 9e-06
Identities = 42/136 (30%), Positives = 68/136 (49%), Gaps = 17/136 (12%)
Query: 103 RLDLLVNCAGIT-QTTAAIKANTNEMADIMNVNFMSSVSLTQLALKQMIRNTKLHGHRGK 161
++D L+N AGI ++ + +E ++ N N + L + ++R+ K G
Sbjct: 119 KIDALINNAGIRGNVKLSLDLSEDEWDNVFNTN-LKGPWLVAKYVCVLMRDAK---RGGS 174
Query: 162 IVNIASVLGDSSSNIIVPGTAMYSASKAAMIQYNRVLSEELKRLSIDVQTISPGLVESTD 221
++NI+SV G S IVPG YS SK + +R+++ EL I V +I+PGL +S
Sbjct: 175 VINISSVAGVRS---IVPGGLAYSCSKGGVDTMSRMMAIELGVHKIRVNSIAPGLFKS-- 229
Query: 222 MIKTLDPEIQQKLREK 237
EI Q L +K
Sbjct: 230 -------EITQALMQK 238
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.132 0.364
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,495,286
Number of Sequences: 60738
Number of extensions: 512465
Number of successful extensions: 1993
Number of sequences better than 1.0e-05: 69
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 68
Number of HSP's that attempted gapping in prelim test: 1920
Number of HSP's gapped (non-prelim): 93
length of query: 259
length of database: 30,389,216
effective HSP length: 104
effective length of query: 155
effective length of database: 24,072,464
effective search space: 3731231920
effective search space used: 3731231920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)