ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3125 check: MH T KOG3519 Signal transduction mechanisms Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3125 1098631 1100901 757
(757 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YAL041w [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and re... 773 0.0
SPAC16E8.09 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 an... 254 4e-67
Hs19882229_1 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 a... 95 3e-19
Hs4507501 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and ... 93 1e-18
7302592 [R] KOG3518 Putative guanine nucleotide exchange factor 93 1e-18
Hs18562992_1 [R] KOG3518 Putative guanine nucleotide exchange fa... 88 4e-17
Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor 88 6e-17
Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor 88 6e-17
Hs15011981 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 87 9e-17
Hs15011979 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 87 9e-17
Hs6912704 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and ... 86 2e-16
7295440 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and re... 83 1e-15
7295439 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and re... 83 1e-15
Hs7662108 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and ... 82 3e-15
Hs20548486 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 82 3e-15
7293570 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 78 6e-14
Hs4504797_2 [T] KOG4305 RhoGEF GTPase 74 8e-13
Hs4507871 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 72 4e-12
Hs11128045_2 [T] KOG4305 RhoGEF GTPase 70 9e-12
Hs6005922_1 [T] KOG4240 Multidomain protein contains SPEC repeat... 70 1e-11
CE08100 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and re... 70 2e-11
HsM7262391 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 69 3e-11
Hs21614496 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 69 3e-11
CE27826 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 67 8e-11
Hs20544361 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 67 1e-10
Hs21245128 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exch... 67 1e-10
CE03042 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchang... 65 4e-10
Hs4758358 [T] KOG4424 Predicted Rho/Rac guanine nucleotide excha... 65 5e-10
Hs20550422 [F] KOG2070 Guanine nucleotide exchange factor 65 5e-10
CE18658 [R] KOG3518 Putative guanine nucleotide exchange factor 64 7e-10
7295262 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchang... 64 7e-10
Hs22047180 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exch... 64 9e-10
Hs5902140_1 [T] KOG0689 Guanine nucleotide exchange factor for R... 64 1e-09
Hs20547239 [T] KOG4240 Multidomain protein contains SPEC repeats... 63 1e-09
Hs4504335 [T] KOG4240 Multidomain protein contains SPEC repeats ... 63 2e-09
Hs22067448 [T] KOG0689 Guanine nucleotide exchange factor for Rh... 63 2e-09
Hs19923310 [T] KOG4240 Multidomain protein contains SPEC repeats... 63 2e-09
CE29398 [T] KOG0689 Guanine nucleotide exchange factor for Rho a... 63 2e-09
CE19467 [T] KOG0689 Guanine nucleotide exchange factor for Rho a... 63 2e-09
CE19466 [T] KOG0689 Guanine nucleotide exchange factor for Rho a... 63 2e-09
CE19464 [T] KOG4240 Multidomain protein contains SPEC repeats PH... 63 2e-09
Hs21735572 [T] KOG3524 Predicted guanine nucleotide exchange fac... 62 2e-09
7298672 [F] KOG2070 Guanine nucleotide exchange factor 62 3e-09
SPAC1006.06 [T] KOG4305 RhoGEF GTPase 62 4e-09
HsM7662064 [T] KOG3522 Predicted guanine nucleotide exchange factor 61 6e-09
Hs21361458 [T] KOG3522 Predicted guanine nucleotide exchange factor 61 6e-09
Hs7108367 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 61 7e-09
7292538 [T] KOG4305 RhoGEF GTPase 61 7e-09
7302235 [T] KOG0689 Guanine nucleotide exchange factor for Rho a... 60 9e-09
Hs9506401 [T] KOG4305 RhoGEF GTPase 60 1e-08
7300304 [T] KOG3522 Predicted guanine nucleotide exchange factor 60 1e-08
7295209 [T] KOG0689 Guanine nucleotide exchange factor for Rho a... 60 1e-08
Hs22052726 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 60 2e-08
7292022 [T] KOG4240 Multidomain protein contains SPEC repeats PH... 59 2e-08
Hs7662310 [T] KOG3531 Rho guanine nucleotide exchange factor CDEP 59 4e-08
Hs19311008 [T] KOG0689 Guanine nucleotide exchange factor for Rh... 59 4e-08
Hs21361487 [T] KOG3523 Putative guanine nucleotide exchange fact... 57 8e-08
Hs19923327 [T] KOG4305 RhoGEF GTPase 57 1e-07
Hs14670377 [T] KOG3520 Predicted guanine nucleotide exchange factor 57 1e-07
7295184 [T] KOG3524 Predicted guanine nucleotide exchange factor... 56 2e-07
YGR070w [T] KOG4305 RhoGEF GTPase 55 5e-07
SPBC29A3.17 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 an... 55 5e-07
Hs15011972 [T] KOG3520 Predicted guanine nucleotide exchange factor 54 7e-07
CE19465 [T] KOG4240 Multidomain protein contains SPEC repeats PH... 54 1e-06
Hs5031633 [T] KOG3531 Rho guanine nucleotide exchange factor CDEP 53 2e-06
CE18264 [T] KOG3524 Predicted guanine nucleotide exchange factor... 53 2e-06
CE01671 [T] KOG3524 Predicted guanine nucleotide exchange factor... 53 2e-06
Hs4885633 [T] KOG3523 Putative guanine nucleotide exchange facto... 52 4e-06
YLR371w [T] KOG4305 RhoGEF GTPase 51 6e-06
Hs20533821 [T] KOG3521 Predicted guanine nucleotide exchange factor 51 8e-06
Hs7662042 [T] KOG3522 Predicted guanine nucleotide exchange factor 50 1e-05
>YAL041w [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 854
Score = 773 bits (1996), Expect = 0.0
Identities = 423/846 (50%), Positives = 554/846 (65%), Gaps = 106/846 (12%)
Query: 5 PSVSNVSLTSVRSNSTHLLMNKKVTAQESLYHMCLMIKKRLEFLPQLQPYLNLAHSSSEI 64
PS +++S+ +MNK VT Q+SL+H+C I+KRLE LPQL+P+L LA+ SSE+
Sbjct: 20 PSATSISIPMQN------VMNKPVTEQDSLFHICANIRKRLEVLPQLKPFLQLAYQSSEV 73
Query: 65 LAEXXXXXXXXXXXXXXXXXXXXXXYEGSSAQSTNGRLXXXXXXXXXXXXXATSFGEDSE 124
L+E SS + R S+ +S
Sbjct: 74 LSERQSLLLSQKQHQELLKSNGAN--RDSSDLAPTLRSSSISTATSLMSMEGISY-TNSN 130
Query: 125 HSQSFNMEDTLLTFSVGITPISVDCDPVTQLSKLFQQGSPLCIIFNAVRPQSKLTVVSSD 184
S + NMEDTLLTFS+GI PI++DCDPVTQLS+LFQQG+PLCI+FN+V+PQ KL V++SD
Sbjct: 131 PSATPNMEDTLLTFSMGILPITMDCDPVTQLSQLFQQGAPLCILFNSVKPQFKLPVIASD 190
Query: 185 DIKICKKSIYDFILGLKQHFAFNDEELFTISDVFSNSTDHFLKVLDVVNTLLNAAPEVFP 244
D+K+CKKSIYDFILG K+HFAFNDEELFTISDVF+NST +KVL+VV TL+N++P +FP
Sbjct: 191 DLKVCKKSIYDFILGCKKHFAFNDEELFTISDVFANSTSQLVKVLEVVETLMNSSPTIFP 250
Query: 245 QIDMSTQL---------ESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRKQLLDN 295
+ Q+ + Q+ +K EY KI+KEF+ TERKYVHDLE+L+KYR+QLLD+
Sbjct: 251 SKSKTQQIMNAENQHRHQPQQSSKKHNEYVKIIKEFVATERKYVHDLEILDKYRQQLLDS 310
Query: 296 QIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWS 355
+I SEELYMLFPNL D IDFQRRFL+SLE+N V KQRIGALFMHSK+FFKLYEPWS
Sbjct: 311 NLITSEELYMLFPNLGDAIDFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEPWS 370
Query: 356 IGQNAAIDFISSSFNKMN-PNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES 414
IGQNAAI+F+SS+ +KM S F+I NK+ELQSFL KPVQRLCRYPLL+K+LL +
Sbjct: 371 IGQNAAIEFLSSTLHKMRVDESQRFIINNKLELQSFLYKPVQRLCRYPLLVKELLAESSD 430
Query: 415 D--SKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDR 472
D +KELE AL I+K+IAR+INENQRRTEN++VVK+LYGRVVNWKGYRI+KFGELLYFD+
Sbjct: 431 DNNTKELEAALDISKNIARSINENQRRTENHQVVKKLYGRVVNWKGYRISKFGELLYFDK 490
Query: 473 ISISTSN-SNEPEKDFEVYLFEKIILLFSEVXXXXXX----------------------- 508
+ IST+N S+EPE++FEVYLFEKII+LFSEV
Sbjct: 491 VFISTTNSSSEPEREFEVYLFEKIIILFSEVVTKKSASSLILKKKSSTSASISASNITDN 550
Query: 509 --------------XXXXXXXXXXXXXXXXXXXXXTNMNDFTKNTG-------------K 541
TN +D N K
Sbjct: 551 NGSPHHSYHKRHSNSSSSNNIHLSSSSAAAIIHSSTNSSDNNSNNSSSSSLFKLSANEPK 610
Query: 542 LDLRGRIMIVNLTQVAPIDNYSLNIIWESAKEKGNFILKFKNEETRNNWESCLHQLLRQI 601
LDLRGRIMI+NL Q+ P +N SLNI WES KE+GNF+LKFKNEETR+NW SCL QL+ +
Sbjct: 611 LDLRGRIMIMNLNQIIPQNNRSLNITWESIKEQGNFLLKFKNEETRDNWSSCLQQLIHDL 670
Query: 602 RSESYK--------SVNTNSDMSSFSSPV-----------QYSHNSVASIGSTLTRQISE 642
++E +K + ++ + SS SP + +H+S+AS S+ +++S+
Sbjct: 671 KNEQFKARHHSSTSTTSSTAKSSSMMSPTTTMNTPNHHNSRQTHDSMASFSSSHMKRVSD 730
Query: 643 VLPKSHMSNARQSFASEYRSISESYKNSIPDTMLLLRVSFNN--------DFYTVLVSLD 694
VLPK +++ SF SE +SISE++KNSIP++ +L R+S+NN + +T+LV
Sbjct: 731 VLPKRRTTSS--SFESEIKSISENFKNSIPESSILFRISYNNNSNNTSSSEIFTLLVEKV 788
Query: 695 CSAEDLLLAIKRKLA-----HLGVITKVKYQDEDGDFVMLESDDDWYVVKDMLKESNERL 749
+ +DL++AI K++ ++ ITK+KYQDEDGDFV+L SD+DW V K+ML E+NE+
Sbjct: 789 WNFDDLIMAINSKISNTHNNNISPITKIKYQDEDGDFVVLGSDEDWNVAKEMLAENNEKF 848
Query: 750 LNVWAY 755
LN+ Y
Sbjct: 849 LNIRLY 854
>SPAC16E8.09 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 872
Score = 254 bits (648), Expect = 4e-67
Identities = 169/535 (31%), Positives = 271/535 (50%), Gaps = 60/535 (11%)
Query: 122 DSEHSQSFNMEDTLLTFSVGITPISVDCDPVTQLSKLFQQGSPLCIIFNAVRPQSKLTV- 180
DS H ++ N +L F I D DPVT++ + G PLC +FN + + KL V
Sbjct: 82 DSIHREALNSSFKILEFK----DIEFD-DPVTEIWLFCRLGYPLCALFNCLPVKQKLEVN 136
Query: 181 --VSSDDIKICKKSIYDFILGLKQHFAFNDEELFTISDVFSNSTDHFLKVLDVVNTLLNA 238
VS ++ +CK S+Y F+L K D LF+IS+++ ST ++ L + LL
Sbjct: 137 SSVSLENTNVCKASLYRFMLMCKNELGLTDAALFSISEIYKPSTAPLVRALQTIELLLK- 195
Query: 239 APEVFPQIDMSTQLESQRLAKPQTEYD--------------KIVKEFIETERKYVHDLEV 284
+ ++S +S P T+ + ++ E ETE KY+ DLE
Sbjct: 196 ------KYEVSNTTKSSSTPSPSTDDNVPTGTLNSLIASGRRVTAELYETELKYIQDLEY 249
Query: 285 LNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHS 344
L+ Y L QI++ + + +F NLN+I+DFQRRFLV LE+N +P ++QR+GALF+
Sbjct: 250 LSNYMVILQQKQILSQDTILSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQRLGALFIAL 309
Query: 345 KYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLL 404
+ F +Y+ + A I + N++ + ++ EL + L+KP+QR+C+YPLL
Sbjct: 310 EEGFSVYQVFCTNFPNAQQLIIDNQNQLLKVAN--LLEPSYELPALLIKPIQRICKYPLL 367
Query: 405 LKDLLQHAESD---SKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRI 461
L LL+ S +EL+ + +A +NE +R EN + L RV++WKGY +
Sbjct: 368 LNQLLKGTPSGYQYEEELKQGMACVVRVANQVNETRRIHENRNAIIELEQRVIDWKGYSL 427
Query: 462 AKFGELLYFDRISISTSNSNEPEKDFEVYLFEKIILLFSEVXXXXXXXXXXXXXXXXXXX 521
FG+LL +D +++ + + E+++ VYLFEKI+L E+
Sbjct: 428 QYFGQLLVWDVVNVCKA---DIEREYHVYLFEKILLCCKEM------------------S 466
Query: 522 XXXXXXXXTNMNDFTKNTGKLDLRGRIMIVNLTQVAP---IDNYSLNIIWESAKEKGNFI 578
+MN TK L L+GRI+ N+T V P + +Y++ I W + +FI
Sbjct: 467 TLKRQARSISMNKKTKRLDSLQLKGRILTSNITTVVPNHHMGSYAIQIFWRGDPQHESFI 526
Query: 579 LKFKNEETRNNWESCLHQLLRQIRSESYKSVNTNSDMSSFSSPVQYSHNSVASIG 633
LK +NEE+ W S L++LL + S K + S S+ ++PV +S S G
Sbjct: 527 LKLRNEESHKLWMSVLNRLLWKNEHGSPKDI--RSAASTPANPVYNRSSSQTSKG 579
>Hs19882229_1 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 387
Score = 95.1 bits (235), Expect = 3e-19
Identities = 69/251 (27%), Positives = 124/251 (48%), Gaps = 24/251 (9%)
Query: 267 IVKEFIETERKYVHDLEVL-----NKYRKQLLDN--QIINSEELYMLFPNLNDIIDFQRR 319
++ E + TER YV L L ++ R+ + D+ + + E + +LF N+ DI++ +
Sbjct: 53 VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112
Query: 320 FLVSLEVN-GQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTN 378
FL +LE P + +G +F+ K F +YE + A+ + NK+ P
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVE-LNKI-PTVRA 170
Query: 379 FVI------GNK---MELQSFLLKPVQRLCRYPLLLKDLLQHA---ESDSKELEIALGIA 426
F++ G K + L+ +LL P+QR+C+YPLLLK+L + D ++ AL
Sbjct: 171 FLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAM 230
Query: 427 KSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKD 486
K++ NINE +R+ E E +++L + W+G + L + S N E+
Sbjct: 231 KTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERA 290
Query: 487 FEVYLFEKIIL 497
F +LF+ +++
Sbjct: 291 F--FLFDNLLV 299
>Hs4507501 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF
GTPases
Length = 1591
Score = 93.2 bits (230), Expect = 1e-18
Identities = 73/261 (27%), Positives = 121/261 (45%), Gaps = 38/261 (14%)
Query: 219 SNSTDHFLKVLDVVNTLLNAAPEV-------FPQIDMSTQLESQRLAKPQTEYDKIVKEF 271
S+ TDH K + V + E+ PQ QL + R K++ E
Sbjct: 989 SDETDHSSKSTEQVAAFCRSLHEMNPSDQNPSPQDSTGPQLATMRQLSDADNVRKVICEL 1048
Query: 272 IETERKYVHDLEVL-NKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQV 330
+ETER YV DL L +Y K L + +EL +LF NL ++++FQ FL +LE ++
Sbjct: 1049 LETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRL 1108
Query: 331 PSQKQRI-------------GALFMHSKYFFKLYEPW--------SIGQNAAIDFISSSF 369
+++ G F++ FKLY + + A D +F
Sbjct: 1109 VPDLEKLEKVDQFKKVLFSLGGSFLYYADRFKLYSAFCAIHTKVPKVLVKAKTDTAFKAF 1168
Query: 370 -NKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKE---LEIALGI 425
+ NP + L+S+L+KP+QR+ +YPLLL++L +++S+E L++A+
Sbjct: 1169 LDAQNPKQQH-----SSTLESYLIKPIQRILKYPLLLRELFALTDAESEEHYHLDVAIKT 1223
Query: 426 AKSIARNINENQRRTENYEVV 446
+A +INE Q+ E + V
Sbjct: 1224 MNKVASHINEMQKIHEEFGAV 1244
>7302592 [R] KOG3518 Putative guanine nucleotide exchange factor
Length = 867
Score = 93.2 bits (230), Expect = 1e-18
Identities = 72/273 (26%), Positives = 123/273 (44%), Gaps = 26/273 (9%)
Query: 247 DMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDL-EVLNKYRKQLLDNQIINSEELYM 305
+ +L Q + +K E +++ER +V DL +V+ Y + + + +EL +
Sbjct: 528 ESENELGDQHHPPAMSVLEKTCLEIVDSERSFVEDLGQVIKGYLQDWKERACLRVDELQI 587
Query: 306 LFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFI 365
LF N+ +I +F L L G+ P RI F+ + F +Y + AI +
Sbjct: 588 LFANIEEIYEFNSMLLQRLINTGRDPG---RIARCFIDLRDGFDVYTTYCTSYPEAISLL 644
Query: 366 SSSFNKMNPNS----TNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELEI 421
+ + S T ++ +++ L S+LLKPVQR+ +Y LLL L +H D KE+
Sbjct: 645 TKLLQATHTYSLLASTQKLLQHRLPLGSYLLKPVQRILKYHLLLDSLRKHC--DVKEVVE 702
Query: 422 ALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGEL-------------- 467
A I + +A NI++ +R+ E VK L G + W G + GEL
Sbjct: 703 AHVIMRQVAHNIDQVKRKQEQQSRVKELSGILDGWLGPELTVLGELRQEGLLMEQHNKQR 762
Query: 468 --LYFDRISISTSNSNEPEKDFEVYLFEKIILL 498
L F + I T + F+ Y+ + ++L
Sbjct: 763 LVLLFATMLIITKQKEDGRLQFKTYISQNNLML 795
>Hs18562992_1 [R] KOG3518 Putative guanine nucleotide exchange factor
Length = 490
Score = 88.2 bits (217), Expect = 4e-17
Identities = 62/244 (25%), Positives = 119/244 (48%), Gaps = 18/244 (7%)
Query: 265 DKIVKEFIETERKYVHDLEVLNKYRKQLLDNQI---INSEELYMLFPNLNDIIDFQRRFL 321
D++V+E +ETER YV DL+ + + + +Q + +EE LF N+ DI F L
Sbjct: 115 DRVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELL 174
Query: 322 VSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSF-NKMNPN---ST 377
LE + I F+ F +Y + ++ ++ NK+
Sbjct: 175 QDLE---NCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRER 231
Query: 378 NFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELEI---ALGIAKSIARNIN 434
+ + + L S+LLKPVQR+ +Y LLL ++ H + D++ ++ A+ + +A +IN
Sbjct: 232 QETLKHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHIN 291
Query: 435 ENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEK 494
+ +R+ E+ ++ + + NWKG + +GEL+ I + + ++LF+K
Sbjct: 292 DMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNER-----TLFLFDK 346
Query: 495 IILL 498
++L+
Sbjct: 347 LLLI 350
>Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor
Length = 646
Score = 87.8 bits (216), Expect = 6e-17
Identities = 62/244 (25%), Positives = 126/244 (51%), Gaps = 10/244 (4%)
Query: 264 YDKIVKEFIETERKYVHDLE-VLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLV 322
Y+ +++ +ETE +Y +L+ VL+ Y + L ++ ++S + L NL +I FQ+ +
Sbjct: 94 YNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQ 153
Query: 323 SLEVNGQVPSQKQRIGALFMHSKYFFK-LYEPWSIGQNAAIDFISSSFNKMNP--NSTNF 379
SLE ++P +QR+G F++ K LY + +A++ ++ ++ +
Sbjct: 154 SLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGA 213
Query: 380 VIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAE---SDSKELEIALGIAKSIARNINEN 436
+ L + L KP RL +YP LLK+L +H E +D ++++ ++ K+++ E
Sbjct: 214 SSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEV 273
Query: 437 QRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEKII 496
++R E ++ L + NW+G I G + Y ++ I + S E + + + LF ++
Sbjct: 274 RKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERY-LLLFPNVL 330
Query: 497 LLFS 500
L+ S
Sbjct: 331 LMLS 334
>Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor
Length = 782
Score = 87.8 bits (216), Expect = 6e-17
Identities = 62/244 (25%), Positives = 126/244 (51%), Gaps = 10/244 (4%)
Query: 264 YDKIVKEFIETERKYVHDLE-VLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLV 322
Y+ +++ +ETE +Y +L+ VL+ Y + L ++ ++S + L NL +I FQ+ +
Sbjct: 251 YNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQ 310
Query: 323 SLEVNGQVPSQKQRIGALFMHSKYFFK-LYEPWSIGQNAAIDFISSSFNKMNP--NSTNF 379
SLE ++P +QR+G F++ K LY + +A++ ++ ++ +
Sbjct: 311 SLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGA 370
Query: 380 VIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAE---SDSKELEIALGIAKSIARNINEN 436
+ L + L KP RL +YP LLK+L +H E +D ++++ ++ K+++ E
Sbjct: 371 SSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEV 430
Query: 437 QRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEKII 496
++R E ++ L + NW+G I G + Y ++ I + S E + + + LF ++
Sbjct: 431 RKRKE--LELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERY-LLLFPNVL 487
Query: 497 LLFS 500
L+ S
Sbjct: 488 LMLS 491
>Hs15011981 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 670
Score = 87.0 bits (214), Expect = 9e-17
Identities = 63/218 (28%), Positives = 113/218 (50%), Gaps = 18/218 (8%)
Query: 267 IVKEFIETERKYVHDL-EVLNKYRKQLLDN-QIINSEELYMLFPNLNDIIDFQRRFLVSL 324
++ E + TER Y+ L ++ Y +Q + + E+L +F N+ DI Q+ F+ +L
Sbjct: 288 VINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKAL 347
Query: 325 E--VNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQ-NAAIDFISSSFNKMNPNSTNFVI 381
E N + P + +GA F+ + F++Y + NA ++ S K++ F
Sbjct: 348 EQRFNRERPHLSE-LGACFLEHQADFQIYSEYCNNHPNACVEL--SRLTKLSKYVYFFEA 404
Query: 382 GNKME------LQSFLLKPVQRLCRYPLLLKDLLQHAES---DSKELEIALGIAKSIARN 432
++ L FLL PVQ++C+YPL L +LL++ D K++E AL K++A+
Sbjct: 405 CRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQL 464
Query: 433 INENQRRTENYEVVKRLYGRVVNWKGY-RIAKFGELLY 469
INE +RR EN + + + + +W+G + + EL+Y
Sbjct: 465 INERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIY 502
>Hs15011979 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 690
Score = 87.0 bits (214), Expect = 9e-17
Identities = 63/218 (28%), Positives = 113/218 (50%), Gaps = 18/218 (8%)
Query: 267 IVKEFIETERKYVHDL-EVLNKYRKQLLDN-QIINSEELYMLFPNLNDIIDFQRRFLVSL 324
++ E + TER Y+ L ++ Y +Q + + E+L +F N+ DI Q+ F+ +L
Sbjct: 288 VINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKAL 347
Query: 325 E--VNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQ-NAAIDFISSSFNKMNPNSTNFVI 381
E N + P + +GA F+ + F++Y + NA ++ S K++ F
Sbjct: 348 EQRFNRERPHLSE-LGACFLEHQADFQIYSEYCNNHPNACVEL--SRLTKLSKYVYFFEA 404
Query: 382 GNKME------LQSFLLKPVQRLCRYPLLLKDLLQHAES---DSKELEIALGIAKSIARN 432
++ L FLL PVQ++C+YPL L +LL++ D K++E AL K++A+
Sbjct: 405 CRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQL 464
Query: 433 INENQRRTENYEVVKRLYGRVVNWKGY-RIAKFGELLY 469
INE +RR EN + + + + +W+G + + EL+Y
Sbjct: 465 INERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIY 502
>Hs6912704 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 1077
Score = 86.3 bits (212), Expect = 2e-16
Identities = 76/266 (28%), Positives = 135/266 (50%), Gaps = 39/266 (14%)
Query: 266 KIVKEFIETERKYVHDLEVLNK-YRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSL 324
K+++E ++TE+ YV DL L + Y + L + + +E+ LF +L ++++FQ+ FL +L
Sbjct: 478 KVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETL 537
Query: 325 EVNG----------QVPSQKQRI----GALFMHSKYFFKLYEPW--------SIGQNAAI 362
E +G + PSQ +++ G F++ FKLY + + + A
Sbjct: 538 E-DGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKT 596
Query: 363 DFISSSF-NKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKE--- 418
D +F + NP + L+S+L+KPVQR+ +YPLLLK+L+ + +S+E
Sbjct: 597 DKAFKAFLDARNPTKQH-----SSTLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYH 651
Query: 419 LEIALGIAKSIARNINENQRRTENYEVV--KRLYGRVVNWKGYRIAKFGELLYFDRISIS 476
L AL + +A +INE Q+ E+Y V + + + K GELL +S
Sbjct: 652 LTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWL 711
Query: 477 TS--NSNEPEKDFE--VYLFEKIILL 498
+ + KD E V++F++ ++L
Sbjct: 712 NPFLSLGKARKDLELTVFVFKRAVIL 737
>7295440 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF
GTPases
Length = 2637
Score = 83.2 bits (204), Expect = 1e-15
Identities = 65/228 (28%), Positives = 110/228 (47%), Gaps = 39/228 (17%)
Query: 249 STQLESQRLAKPQTEYDKIVKEFIETERKYVHDLE-VLNKYRKQLLDNQIINSEELYMLF 307
+T L R + K+V E ++TER YV L +L Y + + +++ E+ LF
Sbjct: 1402 TTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALF 1461
Query: 308 PNLNDIIDFQRRFLVSLEVN-------------GQVPSQKQRIGALFMHSKYFFKLYEPW 354
N+++I+ FQR+FL +LE + GQ + IG+ F++ FKLY +
Sbjct: 1462 GNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSF 1521
Query: 355 SI-------------GQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRY 401
G +A +F+++ K +ST L+S+L+KP+QR+ +Y
Sbjct: 1522 CASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSST---------LESYLIKPIQRILKY 1572
Query: 402 PLLLKDLLQHAESDSKE---LEIALGIAKSIARNINENQRRTENYEVV 446
PLLL+ + ++ + E L AL + +A +INE QR E Y +
Sbjct: 1573 PLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAI 1620
>7295439 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF
GTPases
Length = 2630
Score = 83.2 bits (204), Expect = 1e-15
Identities = 65/228 (28%), Positives = 110/228 (47%), Gaps = 39/228 (17%)
Query: 249 STQLESQRLAKPQTEYDKIVKEFIETERKYVHDLE-VLNKYRKQLLDNQIINSEELYMLF 307
+T L R + K+V E ++TER YV L +L Y + + +++ E+ LF
Sbjct: 1395 TTALTPSRQLTDAEKLRKVVMELVDTERTYVKHLNNLLEHYLEPMKRETFLSNAEINALF 1454
Query: 308 PNLNDIIDFQRRFLVSLEVN-------------GQVPSQKQRIGALFMHSKYFFKLYEPW 354
N+++I+ FQR+FL +LE + GQ + IG+ F++ FKLY +
Sbjct: 1455 GNIHEIVTFQRQFLQNLEESLDLEPDFNKFEHCGQFRNVLFAIGSAFLYYVNHFKLYSSF 1514
Query: 355 SI-------------GQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRY 401
G +A +F+++ K +ST L+S+L+KP+QR+ +Y
Sbjct: 1515 CASHSKAQKVLHPNEGNHALQEFLAARNPKQQHSST---------LESYLIKPIQRILKY 1565
Query: 402 PLLLKDLLQHAESDSKE---LEIALGIAKSIARNINENQRRTENYEVV 446
PLLL+ + ++ + E L AL + +A +INE QR E Y +
Sbjct: 1566 PLLLQQMRNLTDTRADEHVHLCEALKGMEKVAEHINEMQRIHEEYGAI 1613
>Hs7662108 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 516
Score = 82.0 bits (201), Expect = 3e-15
Identities = 63/219 (28%), Positives = 106/219 (47%), Gaps = 20/219 (9%)
Query: 267 IVKEFIETERKYVHDL-EVLNKYRKQLLDNQ-IINSEELYMLFPNLNDIIDFQRRFLVSL 324
++ E + TER Y+ L ++ Y KQ + + + E+L ++F N+ DI FQ F+ L
Sbjct: 107 VINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDL 166
Query: 325 E--VNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIG 382
E N P + IG F+ + F +Y + N +D M +
Sbjct: 167 EKQYNNDDPHLSE-IGPCFLEHQDGFWIYSEYC---NNHLDACMELSKLMKDSRYQHFFE 222
Query: 383 NKMELQS--------FLLKPVQRLCRYPLLLKDLLQHA---ESDSKELEIALGIAKSIAR 431
LQ FLL PVQ++C+YPL L +LL++ SD + + AL + +++ +
Sbjct: 223 ACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQ 282
Query: 432 NINENQRRTENYEVVKRLYGRVVNWKGYRIA-KFGELLY 469
INE +RR EN + + + V++W+G I + EL+Y
Sbjct: 283 QINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIY 321
>Hs20548486 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 652
Score = 82.0 bits (201), Expect = 3e-15
Identities = 66/263 (25%), Positives = 124/263 (47%), Gaps = 18/263 (6%)
Query: 245 QIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDL-EVLNKYRKQLLDNQ-IINSEE 302
Q + ++Q + Q +++E ++TER Y+ L ++ Y +Q + + +
Sbjct: 222 QDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQ 281
Query: 303 LYMLFPNLNDIIDFQRRFLVSLE--VNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNA 360
L +F N+ DI FQR+FL LE N + P + IG+ F+ ++ F +Y +
Sbjct: 282 LATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSE-IGSCFLQNQEGFAIYSEYCNNHPG 340
Query: 361 AIDFISSSFNKMNPNSTNFVIGNKME------LQSFLLKPVQRLCRYPLLLKDLLQHA-- 412
A ++ K F ++ + FLL PVQ++C+YPL L +LL++
Sbjct: 341 AC-LELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQ 399
Query: 413 -ESDSKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIA-KFGELLYF 470
D ++ A K++A INE +R+ E+ + + R +V W+G I + EL++
Sbjct: 400 EHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHS 459
Query: 471 DRISISTSNSNEPEKDFEVYLFE 493
++ T ++ F +LF+
Sbjct: 460 GELTKITKQGKSQQRTF--FLFD 480
>7293570 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 897
Score = 77.8 bits (190), Expect = 6e-14
Identities = 78/380 (20%), Positives = 161/380 (41%), Gaps = 43/380 (11%)
Query: 265 DKIVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSL 324
D +++E I+TE Y+ L L L+ + N +EL ++FP + +++D +FL L
Sbjct: 277 DYVIRELIDTESNYLDVLTALKTKFMGPLERHL-NQDELRLIFPRIRELVDIHTKFLDKL 335
Query: 325 EVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNK-------MNPNST 377
P+ K ++ +F+ + F +Y + AID+++ K +
Sbjct: 336 R-ESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCER 394
Query: 378 NFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHA---ESDSKELEIALGIAKSIARNIN 434
++ +G K++L+ L P+QR+ +Y LLL L++ D + LE A +++ IN
Sbjct: 395 DYNVG-KLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYIN 453
Query: 435 ENQRRTENYEVVKRLYGRVV------NWKGYRIAKFGELLYFDRISISTSNSNEPEKDFE 488
E +R +++ +++++ + N G + ++G LL + I ++ ++ K
Sbjct: 454 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIK-AHEDQKTKLRY 512
Query: 489 VYLFEKIILLFSEVXXXXXXXXXXXXXXXXXXXXXXXXXXXTNMNDFTKNTGKLDLRGRI 548
++F+KI+++ + N+ D+ R
Sbjct: 513 AFVFDKILIMVKALHIKTGDMQYTYRDSH-------------NLADYRVEQS----HSRR 555
Query: 549 MIVNLTQVAPIDNYSLNIIWESAKEKGNFILKFKNEETRNNWESCLHQLLRQIRSESYKS 608
I T+ Y L + +S K F L K+E R+ W L + + + +S
Sbjct: 556 TIGRDTRF----KYQLLLARKSGKTA--FTLYLKSEHERDKWRKALTEAMESLEPPGCQS 609
Query: 609 VNTNSDMSSFSSPVQYSHNS 628
+ ++ +F +P H S
Sbjct: 610 TDHKMEIYTFDAPTTCRHCS 629
>Hs4504797_2 [T] KOG4305 RhoGEF GTPase
Length = 500
Score = 73.9 bits (180), Expect = 8e-13
Identities = 58/222 (26%), Positives = 110/222 (49%), Gaps = 23/222 (10%)
Query: 246 IDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNK-YRKQLLDNQIINSEELY 304
+DM T E +R + E I TE YV+DL+++ + ++K L++++++ +E+
Sbjct: 7 LDMLTPTERKRQG--------YIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVA 58
Query: 305 MLFPNLNDIIDFQRRFLVSLEVNGQVPSQK---QRIGALFMHSKYFFKLYEPWSIGQNAA 361
M+F N ++I + L +L V ++ +K + IG + + Y + Q
Sbjct: 59 MIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNG 118
Query: 362 IDFISSSFNKMNPNSTNFVIGNKME-------LQSFLLKPVQRLCRYPLLLKDLLQHA-- 412
I ++ P+ FV +M+ L SF+LKP+QR+ RYPL++K++L++
Sbjct: 119 AALIQQKTDEA-PDFKEFVKRLEMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPE 177
Query: 413 -ESDSKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRV 453
D L+ AL A+ + +NE R EN + ++ + V
Sbjct: 178 NHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHV 219
>Hs4507871 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 878
Score = 71.6 bits (174), Expect = 4e-12
Identities = 65/248 (26%), Positives = 117/248 (46%), Gaps = 16/248 (6%)
Query: 262 TEYDK---IVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQR 318
TE DK + E ETE KY LE + K L +++ ++ +F NL D+I
Sbjct: 194 TEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPL-RLVLSPADMAAVFINLEDLIKVHH 252
Query: 319 RFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSI----GQNAAIDFISS--SFNKM 372
FL +++V+ V + +F+ K +Y + QN ++S F +
Sbjct: 253 SFLRAIDVSVMVGGST--LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQK 310
Query: 373 NPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHA--ESDSKELEIALGIAKSIA 430
T V K +LQ L+ P+QR+ +Y LLLK+LL H+ + ++L+ AL + +A
Sbjct: 311 VEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDLA 370
Query: 431 RNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVY 490
INE +R E + + N + ++ +FG + + S N ++D ++
Sbjct: 371 MYINEVKRDKETLRKISEFQSSIENLQ-VKLEEFGRPKIDGELKV-RSIVNHTKQDRYLF 428
Query: 491 LFEKIILL 498
LF+K++++
Sbjct: 429 LFDKVVIV 436
>Hs11128045_2 [T] KOG4305 RhoGEF GTPase
Length = 355
Score = 70.5 bits (171), Expect = 9e-12
Identities = 54/220 (24%), Positives = 105/220 (47%), Gaps = 16/220 (7%)
Query: 247 DMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLE-VLNKYRKQLLDNQIINSEELYM 305
D+ T Q + + + Y + E I+TE +Y+ DL+ V+ ++K++ ++ + E+ +
Sbjct: 3 DLQTLDTMQPIERKRQGY---IHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMAL 59
Query: 306 LFPNLNDIIDFQRRFLVSLEVNGQVPSQK---QRIGALFMHSKYFFKLYEPWSIGQNAAI 362
+F N ++I + L +L V + +K Q IG + + Y + Q
Sbjct: 60 IFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGA 119
Query: 363 DFIS------SSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQH---AE 413
+ + F + + M L SFLLKP+QR+ RYPLL++ +L++ +
Sbjct: 120 ALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESH 179
Query: 414 SDSKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRV 453
+D L++AL A+ + +NE R EN + ++ + V
Sbjct: 180 ADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHV 219
>Hs6005922_1 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine nucleotide
exchange factor domains
Length = 2559
Score = 70.1 bits (170), Expect = 1e-11
Identities = 63/248 (25%), Positives = 125/248 (50%), Gaps = 34/248 (13%)
Query: 267 IVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSE---ELYMLFPNLNDIIDFQRRFLVS 323
+++E +ETER YV DL + + L+ + + + ++F N++ I D+ R F +
Sbjct: 1914 VLQELVETERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLG 1973
Query: 324 -LEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIG----QNAAIDFISSSFNKMNPNSTN 378
LE + P +++G+LF+ + +Y + ++ ++I + F +
Sbjct: 1974 ELEKCLEDP---EKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQR--- 2027
Query: 379 FVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQH---AESDSKELEIALGIAKSIARNINE 435
+G++++L L+KPVQR+ +Y LLLKD L++ A D+ ELE A+ + + R N+
Sbjct: 2028 --LGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCND 2085
Query: 436 NQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSN--EPEKDFEVYLFE 493
GR+ + G +A+ G+LL D ++ ++ ++ ++LFE
Sbjct: 2086 MMN-----------VGRLQGFDGKIVAQ-GKLLLQDTFLVTDQDAGLLPRCRERRIFLFE 2133
Query: 494 KIILLFSE 501
+I+ +FSE
Sbjct: 2134 QIV-IFSE 2140
Score = 62.0 bits (149), Expect = 3e-09
Identities = 71/267 (26%), Positives = 125/267 (46%), Gaps = 32/267 (11%)
Query: 185 DIKIC----KKSIYDFILGLKQHFAFNDEELFTISDVFSNSTDHFLKVLDVVNTLLNAAP 240
+IK C K DF L ++++ ++ L SD SN + L+ LD++ + +
Sbjct: 1157 EIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSD--SNKSSKSLQ-LDIIPASIPGS- 1212
Query: 241 EVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDL-EVLNKYRKQLLDNQ--- 296
EV + E +R + + E+ I+ E I+TE+ YV DL E ++ Y ++
Sbjct: 1213 EVKLRDAAHELNEEKRKSARRKEF--IMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEI 1270
Query: 297 ---IINSEELYMLFPNLNDIIDFQRR-FLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYE 352
I+N E ++F N+ +I +F FL LE Q+P +G F+ F++Y
Sbjct: 1271 PPGIVNKE--LIIFGNMQEIYEFHNNIFLKELEKYEQLPED---VGHCFVTWADKFQMYV 1325
Query: 353 PWSIGQNAAIDFI----SSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDL 408
+ + + I S F+++ G + S+L+KPVQR+ +Y LLLK+L
Sbjct: 1326 TYCKNKPDSTQLILEHAGSYFDEIQQRH-----GLANSISSYLIKPVQRITKYQLLLKEL 1380
Query: 409 LQHAESDSKELEIALGIAKSIARNINE 435
L E E++ L + S+ + N+
Sbjct: 1381 LTCCEEGKGEIKDGLEVMLSVPKRAND 1407
>CE08100 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 677
Score = 69.7 bits (169), Expect = 2e-11
Identities = 83/348 (23%), Positives = 154/348 (43%), Gaps = 55/348 (15%)
Query: 268 VKEFIETERKYVHDLEVLNKY---RKQLLDNQIINSE-ELYMLFPNLNDIIDFQRRFLVS 323
++E + TE+KYV DL +N+ +Q+ D I+N+ LY + + D I+ +
Sbjct: 330 LQELLVTEKKYVSDLREMNEVFLCMRQVRD--IMNAAIRLYKMQTSFVDSIEEAIGDMSR 387
Query: 324 LEVN-GQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNP-NSTNFVI 381
+++ Q+ R+ A+F++ FK+Y ++ G + I + ++ + N
Sbjct: 388 QDISVAQIRDSVMRVCAVFINKCSDFKIYAEYAAGYHLLQHEIKNKKELLSKLEAVNSTR 447
Query: 382 GNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKE---LEIALGIAKSIARNINENQR 438
+S ++KPVQR+ +YPLLLK++ D++E +E AL ++ A +NE QR
Sbjct: 448 EQHCSWESRMIKPVQRIVQYPLLLKNIADALPKDARERVQVEAALQKMQTSAEYVNEMQR 507
Query: 439 RTENY----EVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEK 494
E+Y E V++ ++ K R+ ELL F I + P + + V++F
Sbjct: 508 LHEDYAQYMETVRKANEPMLAEKSLRL-DTRELLVFAHIKW----RDAPAEHYVVFVFHS 562
Query: 495 IILLFSEVXXXXXXXXXXXXXXXXXXXXXXXXXXXTNMNDFTKNTGKLDLRGRIMIVNLT 554
+ILL + + + K+ R++ +N
Sbjct: 563 LILL---------------------------------LPSYARKEIKMKWT-RVLPINEV 588
Query: 555 QVAPIDNYSLNI-IWESAKEKGNFILKFKNEETRNNWESCLHQLLRQI 601
+ + N +LN+ ++ +A E N L N T N E C QL + +
Sbjct: 589 DINEMPNDALNLKLYHAAFEGPNGQLSHSNPNTVYNIECCQSQLKQHL 636
>HsM7262391 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 847
Score = 68.9 bits (167), Expect = 3e-11
Identities = 83/413 (20%), Positives = 170/413 (41%), Gaps = 63/413 (15%)
Query: 145 ISVDCDPVTQLSKLFQQGSPLCIIFNAVRPQS----KLTVVSSDDIKICKKSIYDFILGL 200
++ D V L++ + G LC + N +R S ++ + +C K+I F+
Sbjct: 23 VTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTAC 82
Query: 201 KQHFAFNDEELFTISDVFS----------------------------------NSTDHFL 226
+ F ELF D+F N D +
Sbjct: 83 CETFGMRKSELFEAFDLFDVRDFGEVIETLSRLSRTPIALATGIRPFPTEESINDEDIYK 142
Query: 227 KVLDVVN-TLLNAAPEVFPQI-----------DMSTQLESQRLAKPQTEYDKI-VKEFIE 273
+ D+++ TL+ +++ + D+ E+ + P+ + + E +
Sbjct: 143 GLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQ 202
Query: 274 TERKYVHDLEVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQ 333
TE KY LE + KY L + + + E +F N+ +++ R + + + V
Sbjct: 203 TEEKYTETLESIEKYFMAPL-KRFLTAAEFDSVFINIPELVKLHRNLMQEIH-DSIVNKN 260
Query: 334 KQRIGALFMHSKYFFKLYEPWSIGQNAAI---DFISSSFNKMN---PNSTNFVIGNKMEL 387
Q + +F++ K +Y + G +AI D+IS S + + K L
Sbjct: 261 DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNGKFTL 320
Query: 388 QSFLLKPVQRLCRYPLLLKDLLQHA--ESDSKELEIALGIAKSIARNINENQRRTENYEV 445
+ L+ P+QR+ +Y LLL++L++H ++ L++AL K +A+ +NE +R E
Sbjct: 321 RDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLRE 380
Query: 446 VKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEKIILL 498
+K+ + N + FG I I+T + + +++ ++LF+ +++
Sbjct: 381 IKQFQLSIEN-LNQPVLLFGRPQGDGEIRITTLDKH-TKQERHIFLFDLAVIV 431
>Hs21614496 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 847
Score = 68.9 bits (167), Expect = 3e-11
Identities = 83/413 (20%), Positives = 170/413 (41%), Gaps = 63/413 (15%)
Query: 145 ISVDCDPVTQLSKLFQQGSPLCIIFNAVRPQS----KLTVVSSDDIKICKKSIYDFILGL 200
++ D V L++ + G LC + N +R S ++ + +C K+I F+
Sbjct: 23 VTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTAC 82
Query: 201 KQHFAFNDEELFTISDVFS----------------------------------NSTDHFL 226
+ F ELF D+F N D +
Sbjct: 83 CETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESINDEDIYK 142
Query: 227 KVLDVVN-TLLNAAPEVFPQI-----------DMSTQLESQRLAKPQTEYDKI-VKEFIE 273
+ D+++ TL+ +++ + D+ E+ + P+ + + E +
Sbjct: 143 GLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQPKCPENDIRSCCLAEIKQ 202
Query: 274 TERKYVHDLEVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQ 333
TE KY LE + KY L + + + E +F N+ +++ R + + + V
Sbjct: 203 TEEKYTETLESIEKYFMAPL-KRFLTAAEFDSVFINIPELVKLHRNLMQEIH-DSIVNKN 260
Query: 334 KQRIGALFMHSKYFFKLYEPWSIGQNAAI---DFISSSFNKMN---PNSTNFVIGNKMEL 387
Q + +F++ K +Y + G +AI D+IS S + + K L
Sbjct: 261 DQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKSKEDVKLKLEECSKRANNGKFTL 320
Query: 388 QSFLLKPVQRLCRYPLLLKDLLQHA--ESDSKELEIALGIAKSIARNINENQRRTENYEV 445
+ L+ P+QR+ +Y LLL++L++H ++ L++AL K +A+ +NE +R E
Sbjct: 321 RDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLALDAMKDLAQYVNEVKRDNETLRE 380
Query: 446 VKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEKIILL 498
+K+ + N + FG I I+T + + +++ ++LF+ +++
Sbjct: 381 IKQFQLSIEN-LNQPVLLFGRPQGDGEIRITTLDKH-TKQERHIFLFDLAVIV 431
>CE27826 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 935
Score = 67.4 bits (163), Expect = 8e-11
Identities = 109/547 (19%), Positives = 194/547 (34%), Gaps = 122/547 (22%)
Query: 154 QLSKLFQQGSPLCIIFNAVRP----QSKLTVVSSDDIKICKKSIYDFILGLKQHFAFNDE 209
+ + + + G LC + N + P Q K+ + +C +I F + K +F D
Sbjct: 31 EFASVLRDGILLCRLANTLVPNGIDQKKIMRTNQPSPFLCCNNINYFAMFCKTYFNLEDA 90
Query: 210 ELFTISDVF----------------------SNSTDHF---------------------- 225
+LFT D++ S D F
Sbjct: 91 DLFTAEDLYYMNGFQKVLKTLSFLSHTKESLSRGVDPFPDTDNNQEGTSNGSEFEDDVEI 150
Query: 226 -------LKVLDVVNTLLNAAPEVFPQIDMSTQL-------------ESQRLAKPQTEYD 265
++ +D T+ P+ S QL E+ P + +
Sbjct: 151 YQSLHDNIENVDPNRTIYGPITSADPEEQQSEQLYDRIVTNRKPSMNENDLQNTPTLKRN 210
Query: 266 KIVKEFIETERKYVHD--LEVLNKYRKQLLDNQIINSEELYMLFPNLNDI--------ID 315
+ ++E +TE+ YV + ++ + + L II + + ++F N+ +I D
Sbjct: 211 RCIRELYDTEKNYVAQALVTIIKTFYEPL--KGIIPTSDYNIIFGNIEEINVLHTALLAD 268
Query: 316 FQRRFLVSLEVNGQVPSQK--------QRIGALFM--------HSKYFFKLYEPWSIGQN 359
+ V+L ++ P + Q IG +F+ + KY L + +
Sbjct: 269 LEYPVKVALGLSDATPPRPISLNECVPQTIGEVFIKYRDQFLAYGKYCSNLPDSRKLSNE 328
Query: 360 A--AIDFISSSFNKMNPNSTNFVIGN-KMELQSFLLKPVQRLCRYPLLLKDLLQH---AE 413
+FIS + N++ GN K + L P QRL +YPLLLK+L + A
Sbjct: 329 LLKTNEFISRNINELTAQ------GNCKFGMNDLLCVPFQRLTKYPLLLKELQKKTDLAS 382
Query: 414 SDSKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWK---GYRIAKFGELLYF 470
D K LE A+ + + + INE R T +V+ + + + ++ +G +
Sbjct: 383 PDRKSLEEAVEVMEDVCNYINEESRDTNAIKVIDEIEQSITDLSMPLNVKLHDYGRVNLD 442
Query: 471 DRISISTSNSNEPEKDFE--VYLFEKIILLFSEVXXXXXXXXXXXXXXXXXXXXXXXXXX 528
+ ++ S + K + ++LF+K+I+ V
Sbjct: 443 GEVKMAESTLTQAGKPKQRYIFLFDKVIV----VCKAANKVMAAKTTGASARTNTFTYKN 498
Query: 529 XTNMNDFT-KNTGKLDLRGRIMIVNLTQVAPIDNYSLNIIWESAKEKGNFILKFKNEETR 587
M++ T LD++ I TQ I N E FKNE TR
Sbjct: 499 AYVMSELTIDKNASLDVKSGGTITRRTQYVIIMTRDRN----ENNEITQLTFYFKNEATR 554
Query: 588 NNWESCL 594
NNW + L
Sbjct: 555 NNWMTAL 561
>Hs20544361 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 1269
Score = 67.0 bits (162), Expect = 1e-10
Identities = 58/217 (26%), Positives = 98/217 (44%), Gaps = 27/217 (12%)
Query: 242 VFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSE 301
V P +S + QR+ + + K+++E ++TER Y+ DLE+ + + + +
Sbjct: 458 VAPSGSVSAENPEQRMLEKRA---KVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNI 514
Query: 302 ELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFM-HSKYFFKLYEPWSIGQNA 360
+ LF N+ +I ++ L +LE++ V G +F+ H Y+ + +
Sbjct: 515 DFEGLFGNMQMVIKVSKQLLAALEISDAV-------GPVFLGHRDELEGTYKIYCQNHDE 567
Query: 361 AIDFIS-------------SSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKD 407
AI + S + + N + L SFL+KPVQR+ RYPLLL +
Sbjct: 568 AIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLME 627
Query: 408 LLQ---HAESDSKELEIALGIAKSIARNINENQRRTE 441
LL + D L A+ K I NINE +RR +
Sbjct: 628 LLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKD 664
>Hs21245128 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 766
Score = 66.6 bits (161), Expect = 1e-10
Identities = 61/227 (26%), Positives = 108/227 (46%), Gaps = 20/227 (8%)
Query: 239 APEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNK--YRKQL--LD 294
+P Q+D +++ + + KI E + TER YV+ L++L++ Y K L +
Sbjct: 186 SPLELEQLDQHHEMKETN----EQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEAN 241
Query: 295 NQIINSEELYMLFPNLNDIIDFQRRFLV-SLEVNGQVPSQKQRIGALFMHSKYFFKLYEP 353
+E + +F N++ I F +FL+ LE Q RIG + F K+Y
Sbjct: 242 RGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGE 301
Query: 354 WSIGQNAAIDFISSSFNKMNPNSTNFV-------IGNKMELQSFLLKPVQRLCRYPLLLK 406
+ G + A++ + + ++ P + V I + LQ +L+PVQR+ RY +LLK
Sbjct: 302 YVKGFDNAMELVKNMTERI-PQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK 360
Query: 407 DLLQHAESDS---KELEIALGIAKSIARNINENQRRTENYEVVKRLY 450
D L+ DS + + +L I + A + N R+ EN + + +Y
Sbjct: 361 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIY 407
>CE03042 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 875
Score = 65.1 bits (157), Expect = 4e-10
Identities = 60/259 (23%), Positives = 121/259 (46%), Gaps = 19/259 (7%)
Query: 260 PQTEYDK-------IVKEFIETERKYVHDLEVL-NKYRKQLLDNQIINSEELYMLFPNLN 311
P+T+ DK KE +++E++YV L++L + +R +L+ ++I ++++ L N++
Sbjct: 318 PKTDLDKRYQKAWYAAKELVDSEQRYVDKLKLLGDTFRNRLIKEELITNDKITRLLANVS 377
Query: 312 DIIDFQR-RFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFN 370
+ F FL L + + +RI + F K+Y ++ + A
Sbjct: 378 SLYQFHNTHFLPQLLESIRDWHTTKRIANVVRKQAPFLKMYSEYTNNYDRATKLFEELKK 437
Query: 371 KMNPNSTNFVIGNKMELQSF-----LLKPVQRLCRYPLLLKDL---LQHAESDSKELEIA 422
K I + E + L+ PVQR+ RY LLL++ LQ ++ D + +A
Sbjct: 438 KKKFADVVKEIEKQAECEGLPLGHHLICPVQRVMRYQLLLQEYKKHLQPSDVDFDDTTVA 497
Query: 423 LGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNE 482
L + A + NE ++ + + V + ++ N ++ ELL + +S + +
Sbjct: 498 LELVLQAAAHANEMMKKLDRFGKVIEVQEQLGNSISL-VSPGRELLKSGSVQKISSTTEK 556
Query: 483 PEKDFEVYLFEKIILLFSE 501
E+ F ++LF +++L SE
Sbjct: 557 TEERF-IFLFNDLVILASE 574
>Hs4758358 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 961
Score = 64.7 bits (156), Expect = 5e-10
Identities = 61/225 (27%), Positives = 106/225 (47%), Gaps = 26/225 (11%)
Query: 246 IDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNK-YRKQLLDNQIINS---- 300
+ + + ES L Q + I E ++TE+ YV L +L++ + +LL+ S
Sbjct: 357 VPLMERQESVELTVQQKVFH-IANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPA 415
Query: 301 EELYMLFPNLNDIIDFQRRFLV-SLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQN 359
+ ++ +F N+ I F ++FL+ LE + + RIG + F K+Y + +
Sbjct: 416 DVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFD 475
Query: 360 AAIDFISSSFNKMNPNSTNFVI-----------GNKMELQSFLLKPVQRLCRYPLLLKDL 408
A++ + N ST F + GN + LQ +L+PVQR+ RY LLLKD
Sbjct: 476 RAVELV----NTWTERSTQFKVIIHEVQKEEACGN-LTLQHHMLEPVQRIPRYELLLKDY 530
Query: 409 ---LQHAESDSKELEIALGIAKSIARNINENQRRTENYEVVKRLY 450
L H DSK+ + +L + + A + N R+ E + ++Y
Sbjct: 531 LLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVY 575
>Hs20550422 [F] KOG2070 Guanine nucleotide exchange factor
Length = 776
Score = 64.7 bits (156), Expect = 5e-10
Identities = 49/244 (20%), Positives = 117/244 (47%), Gaps = 10/244 (4%)
Query: 264 YDKIVKEFIETERKYVHDLE-VLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLV 322
Y +++ ++TE++Y +L+ +L Y + L N +++ E+ L N ++ FQ+
Sbjct: 242 YTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQ 301
Query: 323 SLEVNGQVPSQKQRIGALFMHSKYFFK-LYEPWSIGQNAAIDFISSSFNKMNPNSTNFVI 381
+LE + P + ++G + FK +Y + +A++ ++ +++ N
Sbjct: 302 ALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGA 361
Query: 382 GNK--MELQSFLLKPVQRLCRYPLLLKDLLQHAES---DSKELEIALGIAKSIARNINEN 436
+ + L + L KP RL +Y LL++L +H E D +++ A+ K++ +
Sbjct: 362 SSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDL 421
Query: 437 QRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEKII 496
++R + ++ L + W+G I G +++ ++ + E E+ + + LF ++
Sbjct: 422 RKRKQ--LELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERY-LMLFSNVL 478
Query: 497 LLFS 500
++ S
Sbjct: 479 IMLS 482
>CE18658 [R] KOG3518 Putative guanine nucleotide exchange factor
Length = 919
Score = 64.3 bits (155), Expect = 7e-10
Identities = 62/279 (22%), Positives = 122/279 (43%), Gaps = 17/279 (6%)
Query: 237 NAAPEVFPQIDMSTQLESQRLAKPQ-TEYDKIVKEFIETERKYVHDLEVLNKYRKQLLDN 295
+A F S+ S L K T D+I E ++TER YV DL N K +D
Sbjct: 196 SAISNTFSLSSQSSARRSALLTKGSLTHLDRIAIELLDTERTYVEDL---NAVIKGYMDF 252
Query: 296 QIINSEELYMLFPNLNDIID-FQRRFLVSLEVNGQVPSQKQ---RIGALFMHSKYFFKLY 351
+ + E+L + ++ + +R F + ++ Q+ + ++ F+ S F+ Y
Sbjct: 253 LVEDREKLKVTLDAISSLFGCIERIFAFNKQLYNQLDAADLDCVKMSRCFVESSGKFEDY 312
Query: 352 EPWSIGQNAAIDFI----SSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKD 407
+ + + + + + ++L ++LLKPVQR+ +Y L L++
Sbjct: 313 IEYCTNYHRMMSTLYHLQQQPLVARALQERQLALNHSLQLSAYLLKPVQRILKYHLFLEN 372
Query: 408 LLQHAESDSKELEI-----ALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIA 462
+L++ S + E+ A + S A IN+ +++ E+ E V +L + WK I
Sbjct: 373 ILKNMPSTTHPEELIQVKRAHEVMTSQAARINDEKKKAEHIERVGQLQSTLQKWKADEIQ 432
Query: 463 KFGELLYFDRISISTSNSNEPEKDFEVYLFEKIILLFSE 501
Y D + +T + ++LFE+++L+ +
Sbjct: 433 ISNLSAYGDLLLEATFRQAGSKTTRLLFLFEEMLLIVKQ 471
>7295262 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 647
Score = 64.3 bits (155), Expect = 7e-10
Identities = 60/229 (26%), Positives = 105/229 (45%), Gaps = 26/229 (11%)
Query: 237 NAAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVL-NKYRKQLLDN 295
N++P P D +L +R A ++E I +E+ Y+ LE+L N + + L +
Sbjct: 53 NSSPIGSPNPDAGKRLGFRRQA---------IQEIISSEKSYLEQLELLMNFFVRPLKEQ 103
Query: 296 QIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWS 355
II+ +LF + I + FL LE N + + F+ FFKLY ++
Sbjct: 104 AIIDCSNHTLLFGQIEMIHNLNGEFLRELEAN------MENVAHAFLKMAPFFKLYSVYA 157
Query: 356 IGQNAAIDFISSSFNKMNPNSTNFVIGNKM------ELQSFLLKPVQRLCRYPLLLKDLL 409
A+ I +K NP F+ + +L S ++ P+QR+ RY LLL+ +L
Sbjct: 158 FDYRGALFIIQDLISK-NPVFRKFLEQTESRPEVQRKLNSLMIVPIQRVPRYKLLLEQVL 216
Query: 410 QH---AESDSKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRVVN 455
+ A++D K L+ ++ ++ A +IN E + + L +VN
Sbjct: 217 LYTSPADADYKLLKESVKEIEATASHINTCVEEQEITQYLIHLQNSLVN 265
>Hs22047180 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 725
Score = 63.9 bits (154), Expect = 9e-10
Identities = 60/244 (24%), Positives = 116/244 (46%), Gaps = 17/244 (6%)
Query: 267 IVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEV 326
I +E + TE YV L +L++ L + I E + +F N++ I F +FL+ E+
Sbjct: 161 IAQELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLP-EL 219
Query: 327 NGQVPSQ---KQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFV--- 380
++ + R+G + F K+Y + + A+ +S+ + + +P + V
Sbjct: 220 KTRITEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVST-WTQRSPLFKDVVHSI 278
Query: 381 ----IGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDS---KELEIALGIAKSIARNI 433
+ + LQ +L+PVQR+ RY LLLKD L+ D+ K+ E +L + + A +
Sbjct: 279 QKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHS 338
Query: 434 NENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFE 493
N R+ E + +Y ++ + + EL+ +I ++ + P+ D ++LF
Sbjct: 339 NAAIRKVEKMHKLLEVYEQLGGEEDI-VNPANELIKEGQIQKLSAKNGTPQ-DRHLFLFN 396
Query: 494 KIIL 497
+IL
Sbjct: 397 SMIL 400
>Hs5902140_1 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 985
Score = 63.5 bits (153), Expect = 1e-09
Identities = 60/259 (23%), Positives = 125/259 (48%), Gaps = 27/259 (10%)
Query: 253 ESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSE---ELYMLFPN 309
E ++ AK ++ E ++TE+ YV DL ++ + + ++ + + + + ++F N
Sbjct: 222 EEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRGKDKIVFGN 281
Query: 310 LNDIIDFQRRF-LVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSS 368
++ I D+ + F L LE + ++ R+ LF+ + +Y W ++I +
Sbjct: 282 IHQIYDWHKDFFLAELE---KCIQEQDRLAQLFIKHERKLHIYV-WYCQNKPRSEYIVAE 337
Query: 369 FNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES---DSKELEIALGI 425
++ I ++ L FL+KP+QR+ +Y LLLKD L+++E + ++E A+ +
Sbjct: 338 YDAYF-EEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVEL 396
Query: 426 AKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISI--STSNSNEP 483
+ + N+ GR+ ++G A+ G+LL D + +
Sbjct: 397 MCLVPKRCNDMMN-----------LGRLQGFEGTLTAQ-GKLLQQDTFYVIELDAGMQSR 444
Query: 484 EKDFEVYLFEKIILLFSEV 502
K+ V+LFE+I+ +FSE+
Sbjct: 445 TKERRVFLFEQIV-IFSEL 462
>Hs20547239 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine
nucleotide exchange factor domains
Length = 1096
Score = 63.2 bits (152), Expect = 1e-09
Identities = 49/182 (26%), Positives = 90/182 (48%), Gaps = 17/182 (9%)
Query: 267 IVKEFIETERKYVHDL---------EVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQ 317
++ E ++TER YV +L E+ N LL + N +++ LF N+ +I F
Sbjct: 638 VMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDV--LFGNMEEIYHFH 695
Query: 318 RR-FLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNS 376
R FL LE P + +G F+ F++YE + + + +
Sbjct: 696 NRIFLRELENYTDCP---ELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQE 752
Query: 377 TNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES--DSKELEIALGIAKSIARNIN 434
+ +K+ L S+LLKPVQR+ +Y LLLK++L+++ + +++L+ AL I + +N
Sbjct: 753 CQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVN 812
Query: 435 EN 436
++
Sbjct: 813 DS 814
>Hs4504335 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine nucleotide
exchange factor domains
Length = 1663
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/195 (27%), Positives = 94/195 (47%), Gaps = 24/195 (12%)
Query: 253 ESQRLAKPQTEYDKIVKEFIETERKYVHDL-EVLNKYRKQLLDNQ------IINSEELYM 305
E +R + + E+ I+ E ++TE+ YV DL E L Y ++ I+N E ++
Sbjct: 1273 EEKRKSARKKEF--IMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKE--HI 1328
Query: 306 LFPNLNDIIDFQRR-FLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQ----NA 360
+F N+ +I DF FL LE Q+P +G F+ F++Y + +
Sbjct: 1329 IFGNIQEIYDFHNNIFLKELEKYEQLPED---VGHCFVTWADKFQMYVTYCKNKPDSNQL 1385
Query: 361 AIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELE 420
++ + F+++ G + S+L+KPVQR+ +Y LLLK+LL E EL+
Sbjct: 1386 ILEHAGTFFDEIQQRH-----GLANSISSYLIKPVQRITKYQLLLKELLTCCEEGKGELK 1440
Query: 421 IALGIAKSIARNINE 435
L + S+ + N+
Sbjct: 1441 DGLEVMLSVPKKAND 1455
>Hs22067448 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 1191
Score = 62.8 bits (151), Expect = 2e-09
Identities = 70/269 (26%), Positives = 125/269 (46%), Gaps = 27/269 (10%)
Query: 238 AAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRKQLLDN-- 295
A P+ P + + + L + Q ++ E + TER+YV LE + LD
Sbjct: 711 ALPQASPTVPPPGSSDPRSLNRLQL----VLAEMVATEREYVRALEYTMENYFPELDRPD 766
Query: 296 --QIINSEELYMLFPNLNDIIDFQRRFLV-SLEVNGQVPSQKQRIGALFMHSKYFFKLYE 352
Q + + + LF NL + DF F + LE + P R+ F+ + F +Y
Sbjct: 767 VPQGLRGQRAH-LFGNLEKLRDFHCHFFLRELEACTRHPP---RVAYAFLRHRVQFGMYA 822
Query: 353 PWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHA 412
+S + + D + SS+ +G+ ++L S+LLKP+QR+ +Y LLL++L +
Sbjct: 823 LYSKNKPRS-DALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARAC 881
Query: 413 ESDSKELEIALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDR 472
++EL AL A+S+ ++ R + + + G VN K + G+L+ D
Sbjct: 882 GGPTQELS-ALREAQSL---VHFQLRHGNDLLAMDAIQGCDVNLK-----EQGQLVRQDE 932
Query: 473 ISISTSNSNEPEKDFEVYLFEKIILLFSE 501
+ T + ++LFE+ +LLFS+
Sbjct: 933 FVVRTGRHKSVRR---IFLFEE-LLLFSK 957
>Hs19923310 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine
nucleotide exchange factor domains
Length = 925
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/215 (25%), Positives = 104/215 (48%), Gaps = 23/215 (10%)
Query: 245 QIDMSTQLESQRLAKPQTEYDK----------IVKEFIETERKYVHDL-EVLNKYRKQLL 293
+I++ + +R + P + D ++ E I+TER YV +L VL YR ++
Sbjct: 467 KIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMD 526
Query: 294 DNQIIN------SEELYMLFPNLNDIIDFQRR-FLVSLEVNGQVPSQKQRIGALFMHSKY 346
+ ++ + + +LF N+ +I +F FL SLE P +R+G F+ K
Sbjct: 527 NPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAP---ERVGPCFLERKD 583
Query: 347 FFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLK 406
F++Y + + + + +++ L S+LLKPVQR+ +Y LLLK
Sbjct: 584 DFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLK 643
Query: 407 DLLQHAE--SDSKELEIALGIAKSIARNINENQRR 439
+LL++++ S L+ AL + +++N++ +
Sbjct: 644 ELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQ 678
>CE29398 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 633
Score = 62.8 bits (151), Expect = 2e-09
Identities = 60/277 (21%), Positives = 130/277 (46%), Gaps = 29/277 (10%)
Query: 238 AAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLE-----VLNKYRKQL 292
A+ V P++ + ++E + + ++ E +ETE+ YV DL + K
Sbjct: 219 ASDAVEPEVALPAKVEKTPEETARFKRSYVLMELVETEQDYVKDLTSVVEGYIGNLNKMD 278
Query: 293 LDNQIINSEELYMLFPNLNDIIDFQR-RFLVSLEVNGQVPSQKQRIGALFM-HSKYFFKL 350
L ++ +++ +F N+ +I++F + FL +E + + GA F+ + + L
Sbjct: 279 LPADLVGKDKI--IFANIVNILEFHKTNFLKEIE---KCSENYEAAGAAFVKYERRLHTL 333
Query: 351 YEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLL- 409
Y + + + ++ + T +G+K+ L L+KPVQR+ +Y LLLKD+L
Sbjct: 334 YVTYCQNKPKSDYLLAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILK 393
Query: 410 --QHAESDSKELEIALGIAKSIARNINENQR--RTENYEVVKRLYGRVVNWKGYRIAKFG 465
+ A+ + L+ AL + + + ++ + R +N++ G++++ G
Sbjct: 394 FTERAKDKTDTLKKALQVMHVVPKACDDMMQVGRLQNFDKSLSAQGKLIHQ--------G 445
Query: 466 ELLYFDRISISTSNSNEPEKDFEVYLFEKIILLFSEV 502
L +IS S + + + KD ++LFE+ ++ +
Sbjct: 446 TL----QISESIAGNVQKPKDRRIFLFEQSAIIADHI 478
>CE19467 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 552
Score = 62.8 bits (151), Expect = 2e-09
Identities = 60/277 (21%), Positives = 130/277 (46%), Gaps = 29/277 (10%)
Query: 238 AAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLE-----VLNKYRKQL 292
A+ V P++ + ++E + + ++ E +ETE+ YV DL + K
Sbjct: 138 ASDAVEPEVALPAKVEKTPEETARFKRSYVLMELVETEQDYVKDLTSVVEGYIGNLNKMD 197
Query: 293 LDNQIINSEELYMLFPNLNDIIDFQR-RFLVSLEVNGQVPSQKQRIGALFM-HSKYFFKL 350
L ++ +++ +F N+ +I++F + FL +E + + GA F+ + + L
Sbjct: 198 LPADLVGKDKI--IFANIVNILEFHKTNFLKEIE---KCSENYEAAGAAFVKYERRLHTL 252
Query: 351 YEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLL- 409
Y + + + ++ + T +G+K+ L L+KPVQR+ +Y LLLKD+L
Sbjct: 253 YVTYCQNKPKSDYLLAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILK 312
Query: 410 --QHAESDSKELEIALGIAKSIARNINENQR--RTENYEVVKRLYGRVVNWKGYRIAKFG 465
+ A+ + L+ AL + + + ++ + R +N++ G++++ G
Sbjct: 313 FTERAKDKTDTLKKALQVMHVVPKACDDMMQVGRLQNFDKSLSAQGKLIHQ--------G 364
Query: 466 ELLYFDRISISTSNSNEPEKDFEVYLFEKIILLFSEV 502
L +IS S + + + KD ++LFE+ ++ +
Sbjct: 365 TL----QISESIAGNVQKPKDRRIFLFEQSAIIADHI 397
>CE19466 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 928
Score = 62.8 bits (151), Expect = 2e-09
Identities = 60/277 (21%), Positives = 130/277 (46%), Gaps = 29/277 (10%)
Query: 238 AAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLE-----VLNKYRKQL 292
A+ V P++ + ++E + + ++ E +ETE+ YV DL + K
Sbjct: 224 ASDAVEPEVALPAKVEKTPEETARFKRSYVLMELVETEQDYVKDLTSVVEGYIGNLNKMD 283
Query: 293 LDNQIINSEELYMLFPNLNDIIDFQR-RFLVSLEVNGQVPSQKQRIGALFM-HSKYFFKL 350
L ++ +++ +F N+ +I++F + FL +E + + GA F+ + + L
Sbjct: 284 LPADLVGKDKI--IFANIVNILEFHKTNFLKEIE---KCSENYEAAGAAFVKYERRLHTL 338
Query: 351 YEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLL- 409
Y + + + ++ + T +G+K+ L L+KPVQR+ +Y LLLKD+L
Sbjct: 339 YVTYCQNKPKSDYLLAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILK 398
Query: 410 --QHAESDSKELEIALGIAKSIARNINENQR--RTENYEVVKRLYGRVVNWKGYRIAKFG 465
+ A+ + L+ AL + + + ++ + R +N++ G++++ G
Sbjct: 399 FTERAKDKTDTLKKALQVMHVVPKACDDMMQVGRLQNFDKSLSAQGKLIHQ--------G 450
Query: 466 ELLYFDRISISTSNSNEPEKDFEVYLFEKIILLFSEV 502
L +IS S + + + KD ++LFE+ ++ +
Sbjct: 451 TL----QISESIAGNVQKPKDRRIFLFEQSAIIADHI 483
>CE19464 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine nucleotide
exchange factor domains
Length = 2488
Score = 62.8 bits (151), Expect = 2e-09
Identities = 60/277 (21%), Positives = 130/277 (46%), Gaps = 29/277 (10%)
Query: 238 AAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLE-----VLNKYRKQL 292
A+ V P++ + ++E + + ++ E +ETE+ YV DL + K
Sbjct: 1784 ASDAVEPEVALPAKVEKTPEETARFKRSYVLMELVETEQDYVKDLTSVVEGYIGNLNKMD 1843
Query: 293 LDNQIINSEELYMLFPNLNDIIDFQR-RFLVSLEVNGQVPSQKQRIGALFM-HSKYFFKL 350
L ++ +++ +F N+ +I++F + FL +E + + GA F+ + + L
Sbjct: 1844 LPADLVGKDKI--IFANIVNILEFHKTNFLKEIE---KCSENYEAAGAAFVKYERRLHTL 1898
Query: 351 YEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLL- 409
Y + + + ++ + T +G+K+ L L+KPVQR+ +Y LLLKD+L
Sbjct: 1899 YVTYCQNKPKSDYLLAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILK 1958
Query: 410 --QHAESDSKELEIALGIAKSIARNINENQR--RTENYEVVKRLYGRVVNWKGYRIAKFG 465
+ A+ + L+ AL + + + ++ + R +N++ G++++ G
Sbjct: 1959 FTERAKDKTDTLKKALQVMHVVPKACDDMMQVGRLQNFDKSLSAQGKLIHQ--------G 2010
Query: 466 ELLYFDRISISTSNSNEPEKDFEVYLFEKIILLFSEV 502
L +IS S + + + KD ++LFE+ ++ +
Sbjct: 2011 TL----QISESIAGNVQKPKDRRIFLFEQSAIIADHI 2043
Score = 53.5 bits (127), Expect = 1e-06
Identities = 48/183 (26%), Positives = 88/183 (47%), Gaps = 23/183 (12%)
Query: 268 VKEFIETERKYVHDLE-VLNKYRK---QLLDNQIINSEE--LYMLFPNLNDIIDFQRRFL 321
++E I++ER Y+ DLE +N Y K Q N I + Y +F N+ I F L
Sbjct: 1210 MRELIQSERDYIKDLERCVNIYVKEFDQAAKNGTIPTLNPLKYEIFGNIEKIFKFHNDKL 1269
Query: 322 VSLEVNGQVPSQKQRIGALFM-HSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFV 380
+ + + +Q + +GA F+ +LY + + + I++ P++ +F
Sbjct: 1270 LHELIKYE--NQPEAVGASFIVWIDLLNELYTEYCVNKEQKNHVIAT------PDAVSFF 1321
Query: 381 IGNKM--------ELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELEIALGIAKSIARN 432
G + E+ S L+KPVQR+ RY LL++ L++ + +L+ A + S+ R
Sbjct: 1322 TGIRERHGLEINNEIASLLIKPVQRITRYRLLIEQLMRSCTDKTNDLKEAYEVVCSVPRK 1381
Query: 433 INE 435
+N+
Sbjct: 1382 VND 1384
>Hs21735572 [T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)
Length = 883
Score = 62.4 bits (150), Expect = 2e-09
Identities = 61/216 (28%), Positives = 98/216 (45%), Gaps = 35/216 (16%)
Query: 249 STQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRKQLLDNQ------IINSEE 302
ST + S++ A+ Q + KE +TE YV+ L + + + L+ + I+ EE
Sbjct: 412 STPVPSKQSARWQ-----VAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEE 466
Query: 303 LYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFM-HSKYFFKLYEPWSIGQNAA 361
+ +F ++ DI D + LE + + IG +F+ +SK K Y P+
Sbjct: 467 IKTIFGSIPDIFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPF------- 519
Query: 362 IDFISSS------FNKMNPNSTNFVIGN-------KMELQSFLLKPVQRLCRYPLLLKDL 408
++F S K P F+ N + L L++PVQRL LLL DL
Sbjct: 520 VNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDL 579
Query: 409 LQHA---ESDSKELEIALGIAKSIARNINENQRRTE 441
+H D LE A+G K + +INE++R+TE
Sbjct: 580 KKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTE 615
>7298672 [F] KOG2070 Guanine nucleotide exchange factor
Length = 687
Score = 62.0 bits (149), Expect = 3e-09
Identities = 54/246 (21%), Positives = 115/246 (45%), Gaps = 21/246 (8%)
Query: 263 EYDKIV-KEFIETERKYVHDLE-VLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRF 320
EY +V K+ +++ER +V +L+ +L + + + QI++ +E L N +I+
Sbjct: 77 EYRSVVLKDLLDSERAHVAELQGLLENFLEPMQQTQILSQDEYAQLMCNFVEIVRTHEDL 136
Query: 321 LVSLEVNGQVPSQKQRIGALFMHSKYFFK-LYEPWSIGQNAAIDFISSSFNKMNP--NST 377
L+ +E R+G LF+ S K +++ + AI + +++
Sbjct: 137 LIQIE------ECNDRVGKLFLTSAPLMKKVHQAYCAAHPKAIVILDKYKDELEKYMERQ 190
Query: 378 NFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES---DSKELEIALGIAKSIARNIN 434
+ L + L KP +RL +Y +L++L +H ES D + + ++ + K IA +
Sbjct: 191 GAATPGLLVLTTGLSKPFRRLDKYSAMLQELERHMESSHPDRGDTQRSVAVYKDIAATCS 250
Query: 435 ENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEK 494
+R+ E ++ L G V W+G ++ G++++ +++ + +D LF +
Sbjct: 251 ATRRQKE--LELQVLTGPVRGWQGQELSTLGDIIHMGSVAVGADH-----RDRYFVLFPQ 303
Query: 495 IILLFS 500
+L S
Sbjct: 304 TLLFLS 309
>SPAC1006.06 [T] KOG4305 RhoGEF GTPase
Length = 1158
Score = 61.6 bits (148), Expect = 4e-09
Identities = 65/257 (25%), Positives = 114/257 (44%), Gaps = 27/257 (10%)
Query: 266 KIVKEFIETERKYVHDLEVLNKYR-KQLLDNQII--NSEELYM--LFPNLNDIIDFQRRF 320
+I+ E I TER +V DLE + + K L + +I N+ + ++ +F N+ I R
Sbjct: 450 EIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQQFIRCVFHNIMQIHAVNSRL 509
Query: 321 LVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPW-SIGQNAAI-DFISSSFNKMNPNSTN 378
+L + IG LF+ + +EP+ G N AI F N N N
Sbjct: 510 SNALNRTQTLQPVVNTIGDLFLD---YVPKFEPFIKYGANQAIAKFEFEREKSTNRNFAN 566
Query: 379 FVI-------GNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELE---IALGIAKS 428
+V K+EL +L KP RL RYPLLL +L++ + D+ + E + + +
Sbjct: 567 YVHEVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDNPDTENIPRVIEMIRE 626
Query: 429 IARNINENQRRTEN----YEVVKRLYGRVVNWKGYRIAKFGELLYFD---RISISTSNSN 481
+N +TEN ++ ++L + + LL F ++ S+ ++
Sbjct: 627 FLTKLNYETGKTENRLSLLQLNEQLSCSPADRAKLTLFDPSRLLIFKGVVKLKASSYSNG 686
Query: 482 EPEKDFEVYLFEKIILL 498
+ E D ++L + +LL
Sbjct: 687 DTENDIHMFLLDNFLLL 703
>HsM7662064 [T] KOG3522 Predicted guanine nucleotide exchange factor
Length = 1510
Score = 61.2 bits (147), Expect = 6e-09
Identities = 54/213 (25%), Positives = 90/213 (41%), Gaps = 28/213 (13%)
Query: 254 SQRLAKPQTEYDK-IVKEFIETERKYVHDLEVLNKYRKQLL---DNQIINSEELY-MLFP 308
S+ +KPQ + K + ++TE+ YV L L + Q L +N ++ L +F
Sbjct: 503 SKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFD 562
Query: 309 NLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHS--------------KYFFKLYEPW 354
+ ++++ +FL + Q +Q++GAL + S F +
Sbjct: 563 QIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAV 622
Query: 355 SIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES 414
+ + A F+ M N K L ++KPVQR+ RY LL+KDLL+H
Sbjct: 623 RVAKEARPAFLKFLEQSMRENK------EKQALSDLMIKPVQRIPRYELLVKDLLKHTPE 676
Query: 415 DSKELEIALGI---AKSIARNINENQRRTENYE 444
D + + L K +A IN+ R E E
Sbjct: 677 DHPDHPLLLEAQRNIKQVAERINKGVRSAEEAE 709
>Hs21361458 [T] KOG3522 Predicted guanine nucleotide exchange factor
Length = 2063
Score = 61.2 bits (147), Expect = 6e-09
Identities = 54/213 (25%), Positives = 90/213 (41%), Gaps = 28/213 (13%)
Query: 254 SQRLAKPQTEYDK-IVKEFIETERKYVHDLEVLNKYRKQLL---DNQIINSEELY-MLFP 308
S+ +KPQ + K + ++TE+ YV L L + Q L +N ++ L +F
Sbjct: 1056 SKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFD 1115
Query: 309 NLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHS--------------KYFFKLYEPW 354
+ ++++ +FL + Q +Q++GAL + S F +
Sbjct: 1116 QIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAV 1175
Query: 355 SIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES 414
+ + A F+ M N K L ++KPVQR+ RY LL+KDLL+H
Sbjct: 1176 RVAKEARPAFLKFLEQSMRENK------EKQALSDLMIKPVQRIPRYELLVKDLLKHTPE 1229
Query: 415 DSKELEIALGI---AKSIARNINENQRRTENYE 444
D + + L K +A IN+ R E E
Sbjct: 1230 DHPDHPLLLEAQRNIKQVAERINKGVRSAEEAE 1262
>Hs7108367 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 845
Score = 60.8 bits (146), Expect = 7e-09
Identities = 62/303 (20%), Positives = 136/303 (44%), Gaps = 19/303 (6%)
Query: 208 DEELFT-ISDVFSNSTDHFLKVLDVVNTLLNAAPEVFPQIDMSTQLESQRLAKPQTEYDK 266
DE++++ +SD ++ + + D V E++ + S E + TEYDK
Sbjct: 138 DEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS---EPVSMPPKMTEYDK 194
Query: 267 ---IVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVS 323
++E +TE KY L + ++ + L + + +++ ++F N+ D++ FL
Sbjct: 195 RCCCLREIQQTEEKYTDTLGSIQQHFLKPLQ-RFLKPQDIEIIFINIEDLLRVHTHFLKE 253
Query: 324 LEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAA---IDFISSSFNKMN---PNST 377
++ P + +F+ K F +Y + +A +D ++++ + +
Sbjct: 254 MKEALGTPGAAN-LYQVFIKYKERFLVYGRYCSQVESASKHLDRVAAAREDVQMKLEECS 312
Query: 378 NFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES--DSKELEIALGIAKSIARNINE 435
+ L+ L+ P+QR+ +Y LLL++L++H + + + L +AL + +A+ +NE
Sbjct: 313 QRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRLALDAMRDLAQCVNE 372
Query: 436 NQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEKDFEVYLFEKI 495
+R E + + N +A +G + I TS + D +L +K
Sbjct: 373 VKRDNETLRQITNFQLSIEN-LDQSLAHYGRPKIDGELKI-TSVERRSKMDRYAFLLDKA 430
Query: 496 ILL 498
+L+
Sbjct: 431 LLI 433
>7292538 [T] KOG4305 RhoGEF GTPase
Length = 1234
Score = 60.8 bits (146), Expect = 7e-09
Identities = 55/220 (25%), Positives = 100/220 (45%), Gaps = 23/220 (10%)
Query: 252 LESQRLAKPQTEYDKIVKEFIETERKYVHDLEV-LNKYRKQLLDNQIINSEELYMLFPNL 310
L ++ K + E +I+ E +ETE KY DL++ L ++ +L ++ E+L +F N
Sbjct: 922 LVCRKCGKKRVERKEIITEIVETEEKYGRDLQIILEEFCHPMLVAGLLTQEQLSAIFLNT 981
Query: 311 NDIIDFQRRFL--------VSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAI 362
D+++ + +SLE G IG +F+ +E + + Q A
Sbjct: 982 EDLLENNQTLAERMRDALDMSLE-QGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQ-AGA 1039
Query: 363 DFISSSFNK--------MNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES 414
+ ++ K + + + +M L SFL+ PVQR+ +YPLLL L + S
Sbjct: 1040 SLLLANLEKEKELLRIFLKVSQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPS 1099
Query: 415 DSKELEIALGIAKSIARNINE-NQRRTENYEVVKRLYGRV 453
+ E+ + I ++N NQ E +V +L+ R+
Sbjct: 1100 HLEGRELLKQAQEKIELHLNHINQ---EAKDVPTKLWRRI 1136
>7302235 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 523
Score = 60.5 bits (145), Expect = 9e-09
Identities = 68/263 (25%), Positives = 114/263 (42%), Gaps = 46/263 (17%)
Query: 267 IVKEFIETERKYVHDL-EVLNKYRKQLLDNQIINSE---ELYMLFPNLNDIIDFQRR-FL 321
I+KE ETE+ YV+++ +L Y +L ++ + + +LF NLN+I F FL
Sbjct: 9 ILKELFETEKIYVNEIASILKGYYDRLKSDESAPASLQGKANVLFGNLNEIYSFHNDVFL 68
Query: 322 VSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAID-------FISSSFNKMNP 374
LE S +R+ F+ KL + D F + +
Sbjct: 69 KDLE---NCISVTERVALCFVKRVRLIKLCKDILKSFTFQRDKFYQLYSFYCQNIQRSEK 125
Query: 375 NSTNFV------------IGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDS--KELE 420
V +G+K+ L ++LLKPVQR+ +Y LLLKDLL ++DS EL+
Sbjct: 126 LRETLVDTHMFFKECQIGLGHKLPLGAYLLKPVQRITKYQLLLKDLLLFTDNDSCRNELK 185
Query: 421 IALGIAKSIARNINENQRRTENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNS 480
AL + + +N++ + + + G +AK GELL D + +
Sbjct: 186 NALDCMLIVLKCVNDSMHQIS-----------ITGFSG-DLAKQGELLMQDSFQVWIESK 233
Query: 481 NE-----PEKDFEVYLFEKIILL 498
+ K ++L++K +LL
Sbjct: 234 KDIRLRMKPKRRHIFLYQKSLLL 256
>Hs9506401 [T] KOG4305 RhoGEF GTPase
Length = 526
Score = 60.1 bits (144), Expect = 1e-08
Identities = 53/222 (23%), Positives = 94/222 (41%), Gaps = 19/222 (8%)
Query: 237 NAAPEVFPQIDMSTQLES------QRLAKPQTEYDKIVKEFIETERKYVHDLEVLNK-YR 289
NAAP + D E+ Q L + + + + E + E + DL++ K Y
Sbjct: 90 NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 149
Query: 290 KQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFK 349
+L I+ +EL +F L+ +I L L + + +G + +
Sbjct: 150 DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLS 209
Query: 350 LYEPWSIGQNAAIDFISSSFNKMNPNSTNFV-------IGNKMELQSFLLKPVQRLCRYP 402
Y+ + Q AA + K + +F+ K++L +FL P RL +YP
Sbjct: 210 SYDSYCSNQVAAKALLDHK--KQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYP 267
Query: 403 LLLKDLLQHAESDS---KELEIALGIAKSIARNINENQRRTE 441
LLL+++L+H +D+ + LE A+ I + I IN +E
Sbjct: 268 LLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE 309
>7300304 [T] KOG3522 Predicted guanine nucleotide exchange factor
Length = 1101
Score = 60.1 bits (144), Expect = 1e-08
Identities = 70/255 (27%), Positives = 118/255 (45%), Gaps = 26/255 (10%)
Query: 267 IVKEFIETERKYVHDLE-VLNKYRKQLLDNQ---IINSEELYMLFPNLNDIIDFQRRFLV 322
+V+E E+ YV L+ V+ KY K L + +I++ + +F + DI++ +FL
Sbjct: 158 VVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLS 217
Query: 323 SLEVNGQVPSQKQRIGALFMHSKYFFKL-----YEPWSIGQNAAIDFISS------SFNK 371
L+ +Q++G FM + F KL Y + N A + I S SF+K
Sbjct: 218 DLKSRLDDWDVQQKVGDAFMDT--FSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSK 275
Query: 372 MNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAE---SDSKELEIALGIAKS 428
+ G K+ L + L+KPVQ+ Y LL + L++H + D+K L+ L +
Sbjct: 276 FLETTAREHKG-KLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHD 334
Query: 429 IARNINENQRR-TEN--YEVVKRLYGRVVNWKGYRIAKFGELLYFDRISISTSNSNEPEK 485
I +IN +R EN E R V+ IA + L FD +S+ + ++
Sbjct: 335 ILVHINCKEREIMENGQREATLRELEGVIEGITDLIAPERQFLLFDLVSMPSGQGARKDR 394
Query: 486 DFEVYLFEKIILLFS 500
F +LF +++L S
Sbjct: 395 GF--FLFNDLLVLTS 407
>7295209 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 594
Score = 60.1 bits (144), Expect = 1e-08
Identities = 66/255 (25%), Positives = 119/255 (45%), Gaps = 29/255 (11%)
Query: 267 IVKEFIETERKYVHDLE-VLNKYRKQLLDNQIINS--EELYMLFPNLNDIIDFQR-RFLV 322
I++E I TER YV L V+ Y +LL I + ++F N+ I +F FL
Sbjct: 43 IMREMIGTERDYVRSLYYVIENYIDELLREDIPQPLRGQRNVIFGNIEKIFEFHNSHFLG 102
Query: 323 SLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIG 382
LE + P ++GA F+ + F LY ++ + + D + S + +
Sbjct: 103 ELERYERNPL---KVGAAFLEMESKFYLYALYNKNKPKS-DTLLSEYGSSFFKPKQMQLQ 158
Query: 383 NKMELQSFLLKPVQRLCRYPLLLKDL-----------LQHAESDSKELEIALGIAKSIAR 431
+K++L S+LLKPVQR+ +Y LLL+ L LQ +D +EL+ A + K R
Sbjct: 159 DKLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAALQEIAADVEELQRAEEMVKFQLR 218
Query: 432 NINE--NQRRTENYEVVKRLYGRVVN------WKGYRIAK-FGELLYFDRISISTSNSNE 482
+ N+ + +V + GR++ W+G K ++ F+ + + +
Sbjct: 219 HGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARRF 278
Query: 483 PE-KDFEVYLFEKII 496
P+ K+ ++Y+++ I
Sbjct: 279 PDHKNLDIYIYKNSI 293
>Hs22052726 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 782
Score = 59.7 bits (143), Expect = 2e-08
Identities = 51/188 (27%), Positives = 90/188 (47%), Gaps = 18/188 (9%)
Query: 268 VKEFIETERKYVHDLEVLNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSL-EV 326
V+E I+TE Y+H L++ + L Q + +L +LF N++DII RFL L E
Sbjct: 35 VRELIDTEVSYLHMLQLCASDIRSRL--QQLPQGDLDVLFSNIDDIIKVNSRFLHDLQET 92
Query: 327 NGQVPSQKQRIGALFMH-SKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIG--- 382
+ Q Q +G +F+ + ++Y+ + + A+ + + + P + G
Sbjct: 93 ASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTY--RKEPELQRHIQGIVE 150
Query: 383 ------NKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKE---LEIALGIAKSIARNI 433
L L+ P+QR+ RYPLLL+ +L++ D+ L+ A+ + + NI
Sbjct: 151 AVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNI 210
Query: 434 NENQRRTE 441
NE + R E
Sbjct: 211 NEYKMRKE 218
>7292022 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine nucleotide
exchange factor domains
Length = 2056
Score = 59.3 bits (142), Expect = 2e-08
Identities = 67/264 (25%), Positives = 117/264 (43%), Gaps = 40/264 (15%)
Query: 253 ESQRLAKPQTEYDKIVKEFIETERKYVHDLEV-----LNKYRK-QLLDNQIINSEELYML 306
E +R + + E+ I+ E ++TER YV+DL L ++R + + + +I E++ +
Sbjct: 1275 EEKRKSARRKEF--IMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDV--I 1330
Query: 307 FPNLNDIIDF-QRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWS----IGQNAA 361
F N+ +I F Q+ FL LE +P +G F+ F +Y + N
Sbjct: 1331 FGNIKEIHHFHQKIFLRELEKYETMPED---VGHCFVTWASKFDMYVHYCKNKPTSNNLL 1387
Query: 362 IDFISSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELEI 421
+ S F ++ + L ++L+KPVQR+ +Y LLLKDLL E E++
Sbjct: 1388 VQHGGSFFEELQRR-----LEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKE 1442
Query: 422 ALGIAKSIARNINENQRRT--ENYEVVKRLYGRVVNWKGYRIAKFGELLYFDRISI-STS 478
L + ++ + N+ + EN +V + K GE++ D T
Sbjct: 1443 GLEVMLNVPKKANDAMHLSLLENCDV--------------SVDKLGEVVLQDAFQAWDTK 1488
Query: 479 NSNEPEKDFEVYLFEKIILLFSEV 502
++ V+LFE +L EV
Sbjct: 1489 QIIRKGRERRVFLFELYLLFAKEV 1512
>Hs7662310 [T] KOG3531 Rho guanine nucleotide exchange factor CDEP
Length = 1054
Score = 58.5 bits (140), Expect = 4e-08
Identities = 53/208 (25%), Positives = 87/208 (41%), Gaps = 18/208 (8%)
Query: 260 PQTEYDKIVKEFIETERKYVHDLEVLNK-YRKQLLDNQIINSEELYMLFPNLNDIIDFQR 318
P E IVKE + TER Y+ DLEV+ +R ++ + + + +LF N++ I +F R
Sbjct: 532 PADEAYFIVKEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHR 591
Query: 319 RFLVSLEVN---------GQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSF 369
FL +E QRIG + + + K + + + + + +
Sbjct: 592 GFLREVEQRLALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKAT 651
Query: 370 N---KMNPNSTNFVIGNK--MELQSFLLKPVQRLCRYPLLLKDLLQH---AESDSKELEI 421
K+ F + + L +FLLKP+QRL Y LLL+ L H D +
Sbjct: 652 KRCKKLEAVYKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHD 711
Query: 422 ALGIAKSIARNINENQRRTENYEVVKRL 449
AL + + R EN + + L
Sbjct: 712 ALKAITEVTTTLQHILIRLENLQKLTEL 739
>Hs19311008 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 474
Score = 58.5 bits (140), Expect = 4e-08
Identities = 66/296 (22%), Positives = 132/296 (44%), Gaps = 31/296 (10%)
Query: 221 STDHFLKVLDVVNTLLNAA-----PEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETE 275
+T L L ++ TLL P + + + E ++ K ++ E +ETE
Sbjct: 7 ATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETE 66
Query: 276 RKYVHDL-EVLNKYRKQLLDNQIINS--EELYMLFPNLNDIIDFQRRFLVSLEVNGQVPS 332
+ YV DL +++ Y + + S ++F N+ I ++ R + L+ +
Sbjct: 67 KMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYF--LQELQRCLK 124
Query: 333 QKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKMELQSFLL 392
+ LF+ + +Y + + + + + S F +G++++L L+
Sbjct: 125 DPDWLAQLFIKHERRLHMYVVYCQNKPKS-EHVVSEFGDSYFEELRQQLGHRLQLNDLLI 183
Query: 393 KPVQRLCRYPLLLKDLLQH---AESDSKELEIALGIAKSIARNINENQRRTENYEVVKRL 449
KPVQR+ +Y LLLKD L++ A D+ +LE A+ + + + N+
Sbjct: 184 KPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCND-----------MMT 232
Query: 450 YGRVVNWKGYRIAKFGELLYFDRISISTSNS----NEPEKDFEVYLFEKIILLFSE 501
GR+ ++G ++ G+LL D ++ + + ++ V+LFE+II +FSE
Sbjct: 233 LGRLRGFEG-KLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQII-IFSE 286
>Hs21361487 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 871
Score = 57.4 bits (137), Expect = 8e-08
Identities = 50/208 (24%), Positives = 94/208 (45%), Gaps = 19/208 (9%)
Query: 254 SQRLAKPQTEYDKIVKEFIETERKYVHDLEVLN---KYRKQLLDNQIINSEELYMLFPNL 310
SQ +++ + + + + E I +E Y+ LE+L K K+L D + E + LF N+
Sbjct: 430 SQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDT--MTKTERHHLFSNI 487
Query: 311 NDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPW------SIGQNAAIDF 364
D+ + ++F + LE Q I + K+ ++P+ + Q +
Sbjct: 488 TDVCEASKKFFIELEARHQNNIFIDDISDIV--EKHTASTFDPYVKYCTNEVYQQRTLQK 545
Query: 365 I---SSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELEI 421
+ + SF ++ + + + SFL+ P+QR+ R PLL+ + Q DS + E+
Sbjct: 546 LLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEV 605
Query: 422 ---ALGIAKSIARNINENQRRTENYEVV 446
AL + R NE R+ E E++
Sbjct: 606 CKRALKEVSKLVRLCNEGARKMERTEMM 633
>Hs19923327 [T] KOG4305 RhoGEF GTPase
Length = 542
Score = 57.0 bits (136), Expect = 1e-07
Identities = 53/215 (24%), Positives = 94/215 (43%), Gaps = 18/215 (8%)
Query: 246 IDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNK-YRKQLLDNQIINSEELY 304
I M L ++ + + + Y E E+ + DL++ K Y +L I++ EEL
Sbjct: 108 ITMKESLTTREIRRQEAIY-----EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELT 162
Query: 305 MLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDF 364
+F +L+ I L + + ++IG + + Y + Q AA
Sbjct: 163 HIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKAL 222
Query: 365 ISSSFNKMNPNSTNFV-------IGNKMELQSFLLKPVQRLCRYPLLLKDLLQHA---ES 414
+ K +P +F+ K++L SFL P RL +YPLLLK++L+H
Sbjct: 223 LDQK--KQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHP 280
Query: 415 DSKELEIALGIAKSIARNINENQRRTENYEVVKRL 449
D + LE A+ I + + +IN + +E + +L
Sbjct: 281 DVQLLEDAILIIQGVLSDINLKKGESECQYYIDKL 315
>Hs14670377 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 1015
Score = 56.6 bits (135), Expect = 1e-07
Identities = 46/211 (21%), Positives = 99/211 (46%), Gaps = 24/211 (11%)
Query: 267 IVKEFIETERKYVHDLEVLNK-YRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLE 325
++ E ++TE +V L+++ K Y + L + +S+ + LFP +D+++ FL L+
Sbjct: 105 VLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLK 164
Query: 326 VNGQVPSQK--------QRIGALFM------HSKYFFKLYEPWSIGQNAAIDFI------ 365
Q ++ Q+IG L + + + + Y + G N A+
Sbjct: 165 ERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQ 224
Query: 366 SSSFNKMNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES---DSKELEIA 422
+ F + NF I ++ +Q +L QR+ +YP+L++ ++Q+ E+ D ++L A
Sbjct: 225 NKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQA 284
Query: 423 LGIAKSIARNINENQRRTENYEVVKRLYGRV 453
L + K I ++ E + ++ + G++
Sbjct: 285 LNLIKDIISQVDAKVSECEKGQRLREIAGKM 315
>7295184 [T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)
Length = 851
Score = 56.2 bits (134), Expect = 2e-07
Identities = 62/236 (26%), Positives = 103/236 (43%), Gaps = 29/236 (12%)
Query: 235 LLNAAPEVFPQIDMSTQLESQRL--AKPQTEYDKIVK---------EFIETERKYVHDLE 283
LL+ + +F +LES +L A+P+ K +F TE YV L+
Sbjct: 345 LLSVSNSLFDCTTSPDKLESDKLLHAEPEASDATPAKKSMRFNHFMDFYTTESNYVGILD 404
Query: 284 -VLNKYRKQL-----LDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRI 337
+LN ++ +L ++ ++N E+ +F N I + + L L + I
Sbjct: 405 TILNLFKNKLEELAETNDPLLNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLI 464
Query: 338 GALFM-HSKYFFKLYEPWSI---GQNAAIDFISSSFNKMNP----NSTNFVIGNKMELQS 389
G + + H K Y P+ + + + + + N T G + LQ
Sbjct: 465 GDIIIQHRDELIKAYPPYVNFFEQMKEQLQYCDREYPRFHAFLKINQTKPECG-RQGLQD 523
Query: 390 FLLKPVQRLCRYPLLLKDLLQHAES---DSKELEIALGIAKSIARNINENQRRTEN 442
+++PVQRL LLL D+L+H S D LE AL K + +INE++RRTE+
Sbjct: 524 LMIRPVQRLPSISLLLNDILKHTTSGNADHGRLEEALKAIKQVTLHINEDKRRTES 579
>YGR070w [T] KOG4305 RhoGEF GTPase
Length = 1155
Score = 54.7 bits (130), Expect = 5e-07
Identities = 49/215 (22%), Positives = 103/215 (47%), Gaps = 16/215 (7%)
Query: 255 QRLAKPQTEYDKIVKEFIETERKYVHDLEVL-NKYRKQLLDNQIINSEE----LYMLFPN 309
+ L+K Q + + + E TE+K+V LE++ + + K+LL+ II S+ + +F +
Sbjct: 456 ESLSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLLETNIIPSDVRINFVKHVFAH 515
Query: 310 LNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPWSIGQNAAIDFISSSF 369
+N+I R FL +L + I +F+ FF + + I ++ +
Sbjct: 516 INEIYSVNREFLKALAQRQSLSPICPGIADIFLQYLPFFDPFLSY-IASRPYAKYLIETQ 574
Query: 370 NKMNPNSTNF--VIGN---KMELQSFLLKPVQRLCRYPLLLKDLLQHAE--SDSKELEIA 422
+NPN F + N + + SFL + V R RY LL+++++ ++ +D +L++
Sbjct: 575 RSVNPNFARFDDEVSNSSLRHGIDSFLSQGVSRPGRYSLLVREIIHFSDPVTDKDDLQML 634
Query: 423 L---GIAKSIARNINENQRRTENYEVVKRLYGRVV 454
+ + K + + I+ ++ VK L +++
Sbjct: 635 MKVQDLLKDLMKRIDRASGAAQDRYDVKVLKQKIL 669
>SPBC29A3.17 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 525
Score = 54.7 bits (130), Expect = 5e-07
Identities = 57/219 (26%), Positives = 99/219 (45%), Gaps = 28/219 (12%)
Query: 249 STQLESQ-RLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRKQLLDNQIINSE-----E 302
ST ES + Q +++EF ++E YVHDL V +Y L +++ SE E
Sbjct: 57 STTTESTIAMRSKQKAIISVLEEFRDSEAAYVHDLHVAQRYYADRLSDRVKKSEWKDVFE 116
Query: 303 LYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQ------KQRIGALFMHSKYFFKLYEPW-- 354
++++ + + + ++ E+N + Q K + LF+ + KL +
Sbjct: 117 IFLVLCKQASLFEIEMHKSLNDEINYILDDQDACLKPKPSVAQLFL--SWLPKLSAVYGR 174
Query: 355 ------SIGQNAAIDFISSSFNK--MNPNSTNFVIGNKMELQSFLLKPVQRLCRYPLLLK 406
+IG+ +SS ++ +S + N L SFL+KPVQR +YPLLL
Sbjct: 175 YCVIQENIGKKVEKWMKNSSISEYLQECDSMAKIESNSWNLDSFLVKPVQRFLKYPLLLN 234
Query: 407 DLLQHAE----SDSKELEIALGIAKSIARNINENQRRTE 441
L + A SD L A ++ ++ +NE +RR +
Sbjct: 235 QLYRSASLGIISDYVLLGEACHKSEIASQRMNELKRRRD 273
>Hs15011972 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 912
Score = 54.3 bits (129), Expect = 7e-07
Identities = 48/203 (23%), Positives = 98/203 (47%), Gaps = 18/203 (8%)
Query: 257 LAKPQTEYDKIVKEFIETERKYVHDLEVLNK-YRKQLLDNQIINSEELYMLFPNLNDIID 315
L K Q + +++ E + TE +V L VL+ + + + + EEL +FP+L+++I+
Sbjct: 410 LPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIE 469
Query: 316 FQRRFLVSLEVNGQVPSQK-QRIGALFM------HSKYFFKLYEPWSIGQNAAIDFISSS 368
FL L Q + IG + + +F K+ + Q+ A++ + +
Sbjct: 470 VHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAK 529
Query: 369 FNKMNPNSTNFVIG-------NKMELQSFLLKPVQRLCRYPLLLKDLLQHAE--SDSKEL 419
K +P FV +++L+ + +QRL +YPLLL+ + Q+ E ++ +++
Sbjct: 530 QRK-DPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKV 588
Query: 420 EIALGIAKSIARNINENQRRTEN 442
E+A + I ++N+ R E+
Sbjct: 589 ELAAECCREILHHVNQAVRDMED 611
>CE19465 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine nucleotide
exchange factor domains
Length = 1638
Score = 53.5 bits (127), Expect = 1e-06
Identities = 48/183 (26%), Positives = 88/183 (47%), Gaps = 23/183 (12%)
Query: 268 VKEFIETERKYVHDLE-VLNKYRK---QLLDNQIINSEE--LYMLFPNLNDIIDFQRRFL 321
++E I++ER Y+ DLE +N Y K Q N I + Y +F N+ I F L
Sbjct: 1210 MRELIQSERDYIKDLERCVNIYVKEFDQAAKNGTIPTLNPLKYEIFGNIEKIFKFHNDKL 1269
Query: 322 VSLEVNGQVPSQKQRIGALFM-HSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFV 380
+ + + +Q + +GA F+ +LY + + + I++ P++ +F
Sbjct: 1270 LHELIKYE--NQPEAVGASFIVWIDLLNELYTEYCVNKEQKNHVIAT------PDAVSFF 1321
Query: 381 IGNKM--------ELQSFLLKPVQRLCRYPLLLKDLLQHAESDSKELEIALGIAKSIARN 432
G + E+ S L+KPVQR+ RY LL++ L++ + +L+ A + S+ R
Sbjct: 1322 TGIRERHGLEINNEIASLLIKPVQRITRYRLLIEQLMRSCTDKTNDLKEAYEVVCSVPRK 1381
Query: 433 INE 435
+N+
Sbjct: 1382 VND 1384
>Hs5031633 [T] KOG3531 Rho guanine nucleotide exchange factor CDEP
Length = 1045
Score = 53.1 bits (126), Expect = 2e-06
Identities = 56/238 (23%), Positives = 104/238 (43%), Gaps = 25/238 (10%)
Query: 231 VVNTLLNAAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRK 290
+++ LLN + P+ D + E +R P + I KE TER Y+ DLEV+ + +
Sbjct: 512 LISPLLN--DQACPRTD--DEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQ 567
Query: 291 QLLDNQIINSEEL-YMLFPNLNDIIDFQRRFLVSLE---------VNGQVPSQKQRIGAL 340
+ + E L ++FPN + F FL +E N Q+ QRIG +
Sbjct: 568 STVSKEDAMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAQI-RDYQRIGDV 626
Query: 341 FMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIGNKME------LQSFLLKP 394
+ + K + A++ + + K + NF +++ L +FLL+P
Sbjct: 627 MLKNIQGMKHLAAHLWKHSEALEALENGI-KSSRRLENFCRDFELQKVCYLPLNTFLLRP 685
Query: 395 VQRLCRYPLLLKDLLQH---AESDSKELEIALGIAKSIARNINENQRRTENYEVVKRL 449
+ RL Y +L+ L +H + +D ++ AL + ++ + EN++ + L
Sbjct: 686 LHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHEL 743
>CE18264 [T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)
Length = 924
Score = 52.8 bits (125), Expect = 2e-06
Identities = 51/239 (21%), Positives = 107/239 (44%), Gaps = 35/239 (14%)
Query: 234 TLLNAAPE-VFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRK-- 290
T LN P+ ++ D+ +S R + ++ E +ETE+ Y+ L+++ K+++
Sbjct: 336 TSLNMTPDYIYSNDDVENSCKSPRQPSKRL---RVCMEMVETEKNYLSLLKLVVKFKEAL 392
Query: 291 --QLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEV------------NGQVPSQKQR 336
++ N+ ++ ++ M+F L+ I++ R L V NG+ K
Sbjct: 393 ECEISHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNEANTLLTVVNGKKNDDKNL 452
Query: 337 -IGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIG----------NKM 385
+++ +K K P I + D I F+K + ++ F +++
Sbjct: 453 DFAQVWIDAKEEMKKAYPQYIN---SYDTIKRLFDKQDRENSKFHTFCKAKESNPEFHRL 509
Query: 386 ELQSFLLKPVQRLCRYPLLLKDLLQHAESDSK-ELEIALGIAKSIARNINENQRRTENY 443
+L ++KPVQRL LLLK++ + ++S K E A + + N+ + + +N+
Sbjct: 510 KLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKNNAEEAAKAIDEVLKTANKTREKNDNF 568
>CE01671 [T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)
Length = 932
Score = 52.8 bits (125), Expect = 2e-06
Identities = 51/239 (21%), Positives = 107/239 (44%), Gaps = 35/239 (14%)
Query: 234 TLLNAAPE-VFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVHDLEVLNKYRK-- 290
T LN P+ ++ D+ +S R + ++ E +ETE+ Y+ L+++ K+++
Sbjct: 336 TSLNMTPDYIYSNDDVENSCKSPRQPSKRL---RVCMEMVETEKNYLSLLKLVVKFKEAL 392
Query: 291 --QLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEV------------NGQVPSQKQR 336
++ N+ ++ ++ M+F L+ I++ R L V NG+ K
Sbjct: 393 ECEISHNEFMSRSDVAMMFGKLDPILELHERIFARLTVMSNEANTLLTVVNGKKNDDKNL 452
Query: 337 -IGALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNFVIG----------NKM 385
+++ +K K P I + D I F+K + ++ F +++
Sbjct: 453 DFAQVWIDAKEEMKKAYPQYIN---SYDTIKRLFDKQDRENSKFHTFCKAKESNPEFHRL 509
Query: 386 ELQSFLLKPVQRLCRYPLLLKDLLQHAESDSK-ELEIALGIAKSIARNINENQRRTENY 443
+L ++KPVQRL LLLK++ + ++S K E A + + N+ + + +N+
Sbjct: 510 KLTDLMVKPVQRLPSVILLLKEMAKKSDSKLKNNAEEAAKAIDEVLKTANKTREKNDNF 568
>Hs4885633 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 519
Score = 51.6 bits (122), Expect = 4e-06
Identities = 55/239 (23%), Positives = 108/239 (45%), Gaps = 26/239 (10%)
Query: 221 STDHFLKVLDVVNTLLNAAPEVFPQIDMSTQLESQRLAKPQTEYDKIVKEFIETERKYVH 280
S++ +L+ L + ++ + + P + ST L S + + ++ E I +E Y+
Sbjct: 58 SSESYLQRLSMASS--GSLWQEIPVVRNSTVLLS--MTHEDQKLQEVKFELIVSEASYLR 113
Query: 281 DLEV-LNKYRKQLLDNQIINSEELYMLFPNLNDIIDFQRRFLVSLEVNGQVPSQKQRI-G 338
L + ++ ++ ++++E LF L D+ D FL LE N + ++
Sbjct: 114 SLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCD 173
Query: 339 ALFMHSKYFFKLYEPWSIGQNAAIDFISSSFNKMNPNSTNF----------VIGNKMELQ 388
+ H+ F ++Y P+ Q + +F + +++NF + ++ L+
Sbjct: 174 VVLNHAPDFRRVYLPYVTNQT----YQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLK 229
Query: 389 SFLLKPVQRLCRYPLLLKDLL---QHAESDSKELEIALGIAKSIARNINEN---QRRTE 441
SFL+ P QR+ R LLL+++L Q S+ E A + + R+ N N RRTE
Sbjct: 230 SFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTE 288
>YLR371w [T] KOG4305 RhoGEF GTPase
Length = 1356
Score = 51.2 bits (121), Expect = 6e-06
Identities = 47/217 (21%), Positives = 101/217 (45%), Gaps = 20/217 (9%)
Query: 255 QRLAKPQTEYDKIVKEFIETERKYVHDLEVL-NKYRKQLLDNQIINSEE----LYMLFPN 309
+ L K + + + + E TE+ +V LE+ + + K L + II+++ + +F +
Sbjct: 651 ENLPKKEIKRQEAIYEVYITEKNFVKSLEITRDTFMKTLAETNIISADIRKNFIKHVFAH 710
Query: 310 LNDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYFFKLYEPW--SIGQNAAIDFISS 367
+NDI RRFL +L + + IG + + F +EP+ + ++
Sbjct: 711 INDIYSVNRRFLKALTDRQRSSPVVRGIGDIVLR---FIPFFEPFVSYVASRPYAKYLIE 767
Query: 368 SFNKMNPNSTNF---VIGNKME--LQSFLLKPVQRLCRYPLLLKDLLQHAE-----SDSK 417
+ +NP F ++ + + + SFL + V R RY LL+K++++ + SD +
Sbjct: 768 TQRSVNPYFARFDDDMMSSSLRHGIDSFLSQGVSRPGRYMLLVKEIMKSTDPEKDKSDYE 827
Query: 418 ELEIALGIAKSIARNINENQRRTENYEVVKRLYGRVV 454
+L A+ + + I++ ++ VK L +++
Sbjct: 828 DLSKAMDALRDFMKRIDQASGAAQDRHDVKLLKQKIL 864
>Hs20533821 [T] KOG3521 Predicted guanine nucleotide exchange factor
Length = 930
Score = 50.8 bits (120), Expect = 8e-06
Identities = 52/220 (23%), Positives = 93/220 (41%), Gaps = 23/220 (10%)
Query: 255 QRLAKPQTEYDKIVKEFIETERKYVHDLEVL-NKYRKQLLDNQ---IINSEELYMLFPNL 310
++L + Q + V E + TE Y+ L V+ N + LL+ Q ++ E LF N+
Sbjct: 328 EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESGLLCEVEAERLFSNI 387
Query: 311 NDIIDFQRRFLVSLEVNGQVPSQKQRIGALFMHSKYF---------FKLYEPWSIGQNAA 361
+I RR S V V + +R AL + FK Y + + +
Sbjct: 388 PEIAQLHRRLWAS--VMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGC 445
Query: 362 IDFISSSFNKMNPNSTNFVIGNK------MELQSFLLKPVQRLCRYPLLLKDLLQHAESD 415
++++ + K ++L L KP QRL +YPLLLK +L+ E
Sbjct: 446 MEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEEP 505
Query: 416 -SKELEIA-LGIAKSIARNINENQRRTENYEVVKRLYGRV 453
+KE +A +G + ++N R+ + + + + R+
Sbjct: 506 RAKEAVVAMIGSVERFIHHVNACMRQRQERQRLAAVVSRI 545
>Hs7662042 [T] KOG3522 Predicted guanine nucleotide exchange factor
Length = 1121
Score = 50.4 bits (119), Expect = 1e-05
Identities = 48/218 (22%), Positives = 102/218 (46%), Gaps = 20/218 (9%)
Query: 257 LAKPQTEYDKIVKEFIETERKYVHDLE-VLNKYRKQL--LDNQIINSEELYMLFPNLNDI 313
L++ Q I+ +++E+ YV L+ +L +Y K L ++ ++++ +L +F + +I
Sbjct: 167 LSQQQVVRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEI 226
Query: 314 IDFQRRFLVSLEVNGQVPSQKQRIGALFMHS---KYFFKLYEPWSIGQNAAIDFISSSFN 370
+ F ++L + IG +F+ S Y + + A+ + +
Sbjct: 227 LQCHSLFQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTC- 285
Query: 371 KMNPNSTNFV------IGNKMELQSFLLKPVQRLCRYPLLLKDLLQHAES---DSKELEI 421
P F+ ++ L S ++KP+QR ++ LLL+D+L++ D L++
Sbjct: 286 ATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQM 345
Query: 422 ALGIAKSIARNINENQR----RTENYEVVKRLYGRVVN 455
AL +++A +NE +R R E ++ K + R +N
Sbjct: 346 ALTELETLAEKLNERKRDADQRCEVKQIAKAINERYLN 383
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.133 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,566,017
Number of Sequences: 60738
Number of extensions: 1595206
Number of successful extensions: 5258
Number of sequences better than 1.0e-05: 71
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 5148
Number of HSP's gapped (non-prelim): 98
length of query: 757
length of database: 30,389,216
effective HSP length: 114
effective length of query: 643
effective length of database: 23,465,084
effective search space: 15088049012
effective search space used: 15088049012
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)