ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3220 good L KOG0970 Replication, recombination and repair DNA polymerase alpha, catalytic subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3220 1130329 1134618 1430
(1430 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL102w [L] KOG0970 DNA polymerase alpha catalytic subunit 1700 0.0
SPAC3H5.06c [L] KOG0970 DNA polymerase alpha catalytic subunit 872 0.0
Hs8393995 [L] KOG0970 DNA polymerase alpha catalytic subunit 663 0.0
7300763 [L] KOG0970 DNA polymerase alpha catalytic subunit 554 e-157
CE26106 [L] KOG0970 DNA polymerase alpha catalytic subunit 548 e-155
At5g67100 [L] KOG0970 DNA polymerase alpha catalytic subunit 546 e-154
ECU05g0990 [L] KOG0970 DNA polymerase alpha catalytic subunit 268 6e-71
CE09308 [L] KOG0969 DNA polymerase delta catalytic subunit 181 1e-44
ECU09g0430 [L] KOG0969 DNA polymerase delta catalytic subunit 174 9e-43
SPBC336.04 [L] KOG0969 DNA polymerase delta catalytic subunit 173 2e-42
Hs4505933 [L] KOG0969 DNA polymerase delta catalytic subunit 166 3e-40
At5g63960 [L] KOG0969 DNA polymerase delta catalytic subunit 146 2e-34
7294203 [L] KOG0969 DNA polymerase delta catalytic subunit 144 1e-33
YDL102w [L] KOG0969 DNA polymerase delta catalytic subunit 138 6e-32
7304154 [L] KOG0968 DNA polymerase zeta catalytic subunit 110 2e-23
Hs4506483 [L] KOG0968 DNA polymerase zeta catalytic subunit 103 2e-21
SPAC688.10 [L] KOG0968 DNA polymerase zeta catalytic subunit 99 5e-20
At1g67500 [L] KOG0968 DNA polymerase zeta catalytic subunit 94 1e-18
CE27403 [L] KOG0968 DNA polymerase zeta catalytic subunit 91 1e-17
YPL167c [L] KOG0968 DNA polymerase zeta catalytic subunit 87 2e-16
CE24463 [B] KOG1911 Heterochromatin-associated protein HP1 and r... 53 4e-06
>YNL102w [L] KOG0970 DNA polymerase alpha catalytic subunit
Length = 1468
Score = 1700 bits (4403), Expect = 0.0
Identities = 867/1473 (58%), Positives = 1079/1473 (72%), Gaps = 52/1473 (3%)
Query: 2 SNANKLELLKKLQKARNNKSNRDVLDEQLEEENVYDLIDEDQYRSKKRQELLRDDFVEDD 61
S + KLE L+KLQ ARN S D ++ + + +YD IDE +YR++KRQELL DDFV DD
Sbjct: 3 SKSEKLEKLRKLQAARNGTSIDDYEGDESDGDRIYDEIDEKEYRARKRQELLHDDFVVDD 62
Query: 62 DGSGYVDRGVDE-WDQSQEFYSDEDDGVDAKSGKKRNKTSKNNKGKDTISDIIKQQNVKR 120
DG GYVDRGV+E W + SDED G A KR K K K I+D+++ Q+ K
Sbjct: 63 DGVGYVDRGVEEDWREVDNSSSDEDTGNLASKDSKRKKNIKREKDHQ-ITDMLRTQHSKS 121
Query: 121 KMTMPTEKPKKVSLA--EFDDILSEFDAEPLVKKPKLTISRKQPAN-----TTPMNYKHP 173
+ +K +K S+ FDDIL EF++ V+KP + + K N T+
Sbjct: 122 TLLAHAKKSQKKSIPIDNFDDILGEFESGE-VEKPNILLPSKLRENLNSSPTSEFKSSIK 180
Query: 174 QVDTSPLKGKDVVPFKADSVNP----------------IDCDSMEEDHDIESLLNDVASS 217
+V+ + D K ++P + + +D++ LL+DV +S
Sbjct: 181 RVNGNDESSHDAGISKKVKIDPDSSTDKYLEIESSPLKLQSRKLRYANDVQDLLDDVENS 240
Query: 218 P--SMSKQKTYQXXXXX--------------XXXXXXIHFGRKKFKSIATQRQMNISAQT 261
P + +Q Q I R+ +S+ T R++NI +++
Sbjct: 241 PVVATKRQNVLQDTLLANPPSAQSLADEEDDEDSDEDIILKRRTMRSVTTTRRVNIDSRS 300
Query: 262 APLTSSPTYVTAPNTPLS----TSTGSTQATESISGSLRQRIPKEDVVDAETGSFNFFWT 317
P TS +VTAP TP+ T + S Q+ ++ +L + KEDVVD ET +F FW
Sbjct: 301 NPSTS--PFVTAPGTPIGIKGLTPSKSLQSNTDVA-TLAVNVKKEDVVDPETDTFQMFWL 357
Query: 318 DFTEVNSSLILFGKVKTRKNQVVSAMAQINGFNRELYFLPKEGKTASDVHQEIVPLLLDK 377
D+ EVN++LILFGKVK + + VSAM QING REL+FLP+EGKT +D+H+EI+PLL+DK
Sbjct: 358 DYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREGKTPTDIHEEIIPLLMDK 417
Query: 378 YGLQSLRAKPETKKYAFELPGIPHEAEYLKVLLPYDTPKCKSITIPAELEGDTFSHVFGG 437
YGL ++RAKP+ KY+FELP IP E++YLKVLLPY TPK TIP++L DTF HVFGG
Sbjct: 418 YGLDNIRAKPQKMKYSFELPDIPSESDYLKVLLPYQTPKSSRDTIPSDLSSDTFYHVFGG 477
Query: 438 NQNLFESFVVQRKIMGPCWLKISDGDFDAVQGASHCAIEVQIDSPNHISATNEKSSPSLN 497
N N+FESFV+Q +IMGPCWL I DF++++ ASHCA+EV +D P +I+ T K+ P+L
Sbjct: 478 NSNIFESFVIQNRIMGPCWLDIKGADFNSIRNASHCAVEVSVDKPQNITPTTTKTMPNLR 537
Query: 498 CISLSIQTVMNAKENKQEIVAISMAVFKNLSQDSSIPQNLKPNEIVTLVRPPQGSTFPPL 557
C+SLSIQT+MN KENKQEIV+I+++ ++N+S DS IP+N+KP+++ TLVRPPQ ++FP
Sbjct: 538 CLSLSIQTLMNPKENKQEIVSITLSAYRNISLDSPIPENIKPDDLCTLVRPPQSTSFPLG 597
Query: 558 LGPKSKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNI 617
L +K++L G VRLFNNEK +L+CFCA+LKV DPDVIIGHRL+ V LDVLAHR ++LNI
Sbjct: 598 LAALAKQKLPGRVRLFNNEKAMLSCFCAMLKVEDPDVIIGHRLQNVYLDVLAHRMHDLNI 657
Query: 618 PQFSVFGRRLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLCDISNEMGQSLTPKCQNWELN 677
P FS GRRLR+ WP+KFG+ N++M F + D+ +GRL+CDI+NEMGQSLTPKCQ+W+L+
Sbjct: 658 PTFSSIGRRLRRTWPEKFGRGNSNMNHFFISDICSGRLICDIANEMGQSLTPKCQSWDLS 717
Query: 678 EMYQVSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEVAFRIQILSLTKQL 737
EMYQV+C E K L+I+Y NP YQ D + M +AL ENI N +I+AEV++RIQ+L+LTKQL
Sbjct: 718 EMYQVTCEKEHKPLDIDYQNPQYQNDVNSMTMALQENITNCMISAEVSYRIQLLTLTKQL 777
Query: 738 TNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEPQVS 797
TNLAGN W QTLGGTRAGRNEYILLHEF+RN +IVPDKE + + +Q++NE+ + V+
Sbjct: 778 TNLAGNAWAQTLGGTRAGRNEYILLHEFSRNGFIVPDKEGNRSRAQKQRQNEENADAPVN 837
Query: 798 SKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDRNPQDNEELPDVP 857
SKK+KYQGGLVFEPEKGLHKNY+LVMDFNSLYPSIIQEFNICFTTVDRN +D +ELP VP
Sbjct: 838 SKKAKYQGGLVFEPEKGLHKNYVLVMDFNSLYPSIIQEFNICFTTVDRNKEDIDELPSVP 897
Query: 858 SREKSRGVLPRLLANLVQRRREVKNLMKTENDASKKAQYDIRQQALKLTANSMYGCLGYV 917
E +GVLPRLLANLV RRREVK +MKTE D K+ Q DIRQQALKLTANSMYGCLGYV
Sbjct: 898 PSEVDQGVLPRLLANLVDRRREVKKVMKTETDPHKRVQCDIRQQALKLTANSMYGCLGYV 957
Query: 918 NSRFYAKPLAMLVTNKGREILMNTRQLAESLGLTVVYGDTDSVMISTGCDNYMDAIKIGE 977
NSRFYAKPLAMLVTNKGREILMNTRQLAES+ L VVYGDTDSVMI TGCDNY DAIKIG
Sbjct: 958 NSRFYAKPLAMLVTNKGREILMNTRQLAESMNLLVVYGDTDSVMIDTGCDNYADAIKIGL 1017
Query: 978 NFKKLVNERYSLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRRE 1037
FK+LVNERY LLEIDIDN+F V DK N T LEVKGLDMKRRE
Sbjct: 1018 GFKRLVNERYRLLEIDIDNVFKKLLLHAKKKYAALTVNLDKNGNGTTVLEVKGLDMKRRE 1077
Query: 1038 FCPLSKEVSTRVLNILLSDKDSESALQEIYAYMEEIRQKVENNEIRMDKYKINTRLSKDP 1097
FCPLS++VS VLN +LSDKD E ALQE+Y Y+E+IR KVE N IR+DKYKIN +LSKDP
Sbjct: 1078 FCPLSRDVSIHVLNTILSDKDPEEALQEVYDYLEDIRIKVETNNIRIDKYKINMKLSKDP 1137
Query: 1098 KSYPGGKNMPAVQVALRMREAGRVVKAGSVITFVITKGXXXXXXXXXXA-NVAERARALN 1156
K+YPGGKNMPAVQVALRMR+AGRVVKAGSVITFVITK A +VAERA ALN
Sbjct: 1138 KAYPGGKNMPAVQVALRMRKAGRVVKAGSVITFVITKQDEIDNAADTPALSVAERAHALN 1197
Query: 1157 EVMNKKNGLKPDPVYYLGKQIFSPVQRLLERIESFDIIRLSEALGLDSRKYINRGGANGE 1216
EVM K N L PDP YYL KQIF+PV+RLLERI+SF+++RLSEALGLDS+KY R G N
Sbjct: 1198 EVMIKSNNLIPDPQYYLEKQIFAPVERLLERIDSFNVVRLSEALGLDSKKYFRREGGNN- 1256
Query: 1217 LNGRGMDTLQPLETTISDEERFRDSVPLELTCPNCDTKFVYGGIVASKEYRFVYSGIQCS 1276
NG ++ LQPLETTI+D ERF+D+V LEL+CP+CD +F +GGIV+S YR Y+G+QC
Sbjct: 1257 -NGEDINNLQPLETTITDVERFKDTVTLELSCPSCDKRFPFGGIVSSNYYRVSYNGLQCK 1315
Query: 1277 NCNHIMTPIQVTSQLERIIRAHISLYYAGWVACDDSTCGNITRQISVFGKRCLLDGCTGV 1336
+C + TP+Q+TSQ+E IRAHISLYYAGW+ CDDSTCG +TRQ+SVFGKRCL DGCTGV
Sbjct: 1316 HCEQLFTPLQLTSQIEHSIRAHISLYYAGWLQCDDSTCGIVTRQVSVFGKRCLNDGCTGV 1375
Query: 1337 MSYKYSDKQLYNQMLYFQSLFDLQKNKLQTLKPLYHSGDSNAPEKSLSHSEVQALAEQNR 1396
M YKYSDKQLYNQ+LYF SLFD +KNK Q LKP+Y D + P++ L+ S ++AL EQNR
Sbjct: 1376 MRYKYSDKQLYNQLLYFDSLFDCEKNKKQELKPIYLPDDLDYPKEQLTESSIKALTEQNR 1435
Query: 1397 LLFEVSKQVVEKYLSDCGRAYVNMGSIFDFMLS 1429
L E + VV+KYL+DCGR YV+M SIFDFML+
Sbjct: 1436 ELMETGRSVVQKYLNDCGRRYVDMTSIFDFMLN 1468
>SPAC3H5.06c [L] KOG0970 DNA polymerase alpha catalytic subunit
Length = 1405
Score = 872 bits (2253), Expect = 0.0
Identities = 540/1405 (38%), Positives = 789/1405 (55%), Gaps = 125/1405 (8%)
Query: 12 KLQKARNNKSNRDVLDEQLEEENVYDLIDEDQYRSKKRQELLRDDFVEDDDGSGYVDRGV 71
+L+ R R E E E +YD + E++YR RQ L DDFV DD+G+GYVD G
Sbjct: 16 ELRALRQAGKTRASTYESKENEELYDNVSEEEYRKIVRQRLDEDDFVVDDNGAGYVDNGY 75
Query: 72 DEWDQSQEFYSDEDDGVD-AKSGKKRNKTS----------------------------KN 102
DEWDQS YSDEDD + SG+KR K+ KN
Sbjct: 76 DEWDQSH--YSDEDDENEKGSSGRKRKKSKNVLAEPNQQIGAFFKANAIQPASRIANRKN 133
Query: 103 NKGKDTI---------SDIIKQQNVK---RKMTMPTEKPKKVSLAEFDDILSEFDAEPLV 150
N+ +D DI ++ + K R T K + A + ++P
Sbjct: 134 NEKEDEFMAEILGSIDQDIPERLSTKKGNRSHTTSNAKRRSQKAASSISTTNVVSSDPKK 193
Query: 151 KKPKLTISRKQPANTTPMNYKHPQVDTSPLKGKDVVPFKADSVNPIDCDSMEEDHDIESL 210
P+ S QPA++ P+ P + L+ ++ V DS P++ D E ++
Sbjct: 194 YIPETVPSTPQPASSLPI----PSSPPAALETEENV----DS-QPMELDEPELPVGSDAP 244
Query: 211 LNDVASSPSMSKQKTYQXXXXXXXXXXXIHFGRKKFKSIATQRQMNISAQTAPLTSSPTY 270
+ DV S +M ++ S AT Q +S T PL+S
Sbjct: 245 IIDVEESIAMKPLMSHDQVDDTASL------------SKATISQQPLSPMT-PLSSELD- 290
Query: 271 VTAPNTPLSTSTGSTQATESISGSLRQRIPKEDVVDAETGSFNFFWTDFTEVNSSLILFG 330
+ + +++ + S S ++ DV + E GS FFW D+TE+ SL LFG
Sbjct: 291 -VSAFSEINSKIKNVDVPASSYSSPISKVSPSDVTE-EDGSLFFFWMDYTEMYGSLCLFG 348
Query: 331 KVKTRKN-QVVSAMAQINGFNRELYFLPKEGKTA----------SDVHQEIVPLLLDKYG 379
KV + Q VS +++G R LYFLP+ ++ DV+ E+ LL K G
Sbjct: 349 KVYDKATKQYVSCFLKVDGIMRSLYFLPRPSSSSVSEDSIAAQTKDVYDEVANLL-SKRG 407
Query: 380 LQSLRAKPETKKYAFELPGIPHEAEYLKVLLPYDTPKCKSITIPAELEGDTFSHVFGGNQ 439
++ +++ KYAFEL +P A+YL+V+ Y P +P +L G +FSHVFG N
Sbjct: 408 VKEWKSRVSKYKYAFELEDVPRTADYLEVIYSYSYP-----ALPTDLTGSSFSHVFGTNT 462
Query: 440 NLFESFVVQRKIMGPCWLKISDGDFDAVQGASHCAIEVQIDSPNHISATNEKS-----SP 494
LFE FV+ R++MGPCWLKI +FDAV+ AS C +E+ SP +IS + EK+ +P
Sbjct: 463 ALFEQFVLSRRVMGPCWLKIQQPNFDAVKNASWCRVEIGCSSPQNISVSFEKNEITSKTP 522
Query: 495 SLNCISLSIQTVMNAKENKQEIVAISMAVFKNLSQDSSIPQNLKPNEIVTLVRPPQGSTF 554
+ +SL+ +T++N ++NKQE+V IS +F+N+ + +P N P+ +L+RP + F
Sbjct: 523 PMTVMSLAFRTLINKEQNKQEVVMISARIFENVDIEKGLPANDMPSYSFSLIRPLK-QIF 581
Query: 555 PPLLGPKSKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYE 614
P K ++ ++ +E +LLN F ++ DPDV GH E + VL R E
Sbjct: 582 PNGF-EKLARQHKSSIFCERSEVSLLNNFLNKVRTYDPDVYFGHDFE-MCYSVLLSRLKE 639
Query: 615 LNIPQFSVFGRRLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLCDISNEMGQSLTPKCQNW 674
I +S GR R WP F N S QF+ + + AGRL+CD+SN+ G+S+ K Q+W
Sbjct: 640 RKIHNWSSIGRLRRSEWPRSF---NRSSQQFVEKQIIAGRLMCDLSNDFGRSMI-KAQSW 695
Query: 675 ELNEMYQVSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEVAFRIQILSLT 734
L+E+ I+R+ + + + +L L ++ A VAF+IQ+L L+
Sbjct: 696 SLSEIVLKELDIKRQDINQEKALQSWTDTAHGLLDYLVHCEIDTFFIAAVAFKIQMLQLS 755
Query: 735 KQLTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPM-E 793
K LTN+AGN W +TL GTRA RNEYILLHEF +N YIVPDK+ + ED + E
Sbjct: 756 KNLTNIAGNSWARTLTGTRAERNEYILLHEFKKNGYIVPDKQQSIRRHAEAFGAEDGLQE 815
Query: 794 PQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDRNPQDNE-- 851
+ KK KY+GGLVFEP+KGL++ ILVMDFNSLYPSIIQE+NICFTTVDR+P +++
Sbjct: 816 ESLGKKKDKYKGGLVFEPQKGLYETCILVMDFNSLYPSIIQEYNICFTTVDRSPSNSDSD 875
Query: 852 -ELPDVPSREKSRGVLPRLLANLVQRRREVKNLMKTENDAS--KKAQYDIRQQALKLTAN 908
++PD PS ++G+ PRL+ANLV+RRR++K L+K +N A+ ++ Q+DI+QQALKLTAN
Sbjct: 876 DQIPDTPSASANQGIFPRLIANLVERRRQIKGLLK-DNSATPTQRLQWDIQQQALKLTAN 934
Query: 909 SMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESLGLTVVYGDTDSVMISTGCDN 968
SMYGCLGY SRFYA+PLA+L+T KGRE LMNT++LA+ +GL V+YGDTDSVM++T +
Sbjct: 935 SMYGCLGYTKSRFYARPLAVLITYKGREALMNTKELADQMGLQVIYGDTDSVMLNTNVTD 994
Query: 969 YMDAIKIGENFKKLVNERYSLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEV 1028
A++IG FK+ VNERYS LEIDIDN++ + D Q K L+V
Sbjct: 995 KNHALRIGNEFKEKVNERYSKLEIDIDNVYQRMLLHAKKKYAA--LQLDSQG--KPNLDV 1050
Query: 1029 KGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYAYMEEIRQKVENNEIRMDKYK 1088
KGLDMKRREFC L+KE S L+ +LS + +E+ ++ I++Y+ + +K+ N + +K+
Sbjct: 1051 KGLDMKRREFCTLAKEASKFCLDQILSGELTETVIENIHSYLMDFSEKMRNGKFPANKFI 1110
Query: 1089 INTRLSKDPKSYPGGKNMPAVQVALRMREAGRVVKAGSVITFVITKGXXXXXXXXXXANV 1148
I RL K+P+ YP GK MP VQVAL+ + G V+ G VI F+I +
Sbjct: 1111 IFNRLGKNPEDYPNGKTMPFVQVALKKKARGENVRVGDVIPFII-------AGSDADGHP 1163
Query: 1149 AERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLERIESFDIIRLSEALGLDSRKYI 1208
A+RA + E+MN + L D YYL QI P++R++ IE + RL+E LGLD+RKY
Sbjct: 1164 ADRAYSPQEIMNTNSTLVIDYNYYLSHQILPPIERVIAPIEGTNRARLAECLGLDARKYY 1223
Query: 1209 NRGGANGELNGRGMDTLQPLETTISDEERFRDSVPLELTCPNCD-TKFVYGGIVASKEYR 1267
+ + Q E+T++D++ F + PL L CP+C+ T F + + KE
Sbjct: 1224 SHETSES-------SAFQRYESTLTDDQCFINVSPLLLKCPSCNATSFSLRSVKSLKETL 1276
Query: 1268 FVYSGIQCSNCNHIMTPIQVTSQLERIIRAHISLYYAGWVACDDSTCGNITRQISVFGKR 1327
+ + ++C +C + + + Q +R I+LYY G + CDDS+CGN TRQ+SV+GKR
Sbjct: 1277 YA-NTVEC-DCGYEYSDFTIILQFSSQLRDFINLYYEGILVCDDSSCGNRTRQMSVYGKR 1334
Query: 1328 CLLDGCTGVMSYKYSDKQLYNQMLY 1352
C C G + ++Y+D+QLYNQ+ +
Sbjct: 1335 CCNKSCRGSVHFEYNDEQLYNQIKF 1359
>Hs8393995 [L] KOG0970 DNA polymerase alpha catalytic subunit
Length = 1462
Score = 663 bits (1710), Expect = 0.0
Identities = 473/1486 (31%), Positives = 739/1486 (48%), Gaps = 120/1486 (8%)
Query: 2 SNANKLELLKKLQKARNNKSNRDVLDEQLEEENVYDLIDEDQYRSKKRQELLRDDFVEDD 61
S + E L++L+KA+ + + +++ VY+ +DE+QY SK Q DD++ DD
Sbjct: 27 SKKGRQEALERLKKAKAGEKYKYEVEDFT---GVYEEVDEEQY-SKLVQARQDDDWIVDD 82
Query: 62 DGSGYVDRGVDEWDQSQEFYSDEDDGVDA----KSGKKRNKTSKNNKGKDTISDIIKQQN 117
DG GYV+ G + +D E DD +DA K GK RNK +N K + K N
Sbjct: 83 DGIGYVEDGREIFDDDLE-----DDALDADEKGKDGKARNKDKRNVKKLA----VTKPNN 133
Query: 118 VKRKMTMPTEKP---KKVSLAE---FDDILSEFDAE-PLVKKPKLTISRKQPANTTPMNY 170
+K K K V L++ DIL + + E P + P + I +K+ + N
Sbjct: 134 IKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNP 193
Query: 171 KHPQVDTSPLKGKDVVPF--KADSVNPIDCDSME---EDHDIESLLNDVASSPSMSKQKT 225
T+ GK P K + P+ E +D +ES + S +
Sbjct: 194 FSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGD 253
Query: 226 YQXXXXXXXXXXXIHFGRKKFKSIATQRQMNISAQTAPLTSSPTYVTAPNTPL------S 279
+ + K ++ A + T S P+
Sbjct: 254 FDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEG 313
Query: 280 TSTGSTQATESISGSLRQRIPKEDVVDAETGSFNFFWTDFTEVNSS----LILFGKVKTR 335
S+ S Q + S L P D E F+F+W D E + + LFGKV
Sbjct: 314 DSSFSVQEVQVDSSHL----PLVKGADEEQ-VFHFYWLDAYEDQYNQPGVVFLFGKVWIE 368
Query: 336 KNQV-VSAMAQINGFNRELYFLPKEGK-------------TASDVHQEIVPLLLDKYGLQ 381
+ VS + R LYFLP+E K + DV++E + KY +
Sbjct: 369 SAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIM 428
Query: 382 SLRAKPETKKYAFELPGIPHEAEYLKVLLPYDTPKCKSITIPAELEGDTFSHVFGGNQNL 441
++KP K YAFE+P +P ++EYL+V + P+ +P +L+G+TFSHVFG N +
Sbjct: 429 KFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQ-----LPQDLKGETFSHVFGTNTSS 483
Query: 442 FESFVVQRKIMGPCWLKISDGDFDAVQGASHCAIEVQIDSPNHISATNEKSSPSLNCISL 501
E F++ RKI GPCWL++ Q S C +E P+ ++ + S P L ++
Sbjct: 484 LELFLMNRKIKGPCWLEVKKSTA-LNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAF 542
Query: 502 SIQTVMNAKENKQEIVAISMAVFKNLSQDSSIPQNLKPNEIVTLVRPPQGSTFPPLLGPK 561
S++T+ NAK ++ EI+A++ V + + D + P+ + +V P+ FP
Sbjct: 543 SMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFC-VVSKPKDCIFPYAFKEV 601
Query: 562 SKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNIPQFS 621
+K+ + V + E+TLL F A + DPD+I+GH + G L+VL R P +S
Sbjct: 602 IEKK-NVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWS 660
Query: 622 VFGRRLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLCDISNEMGQSLTPKCQNWELNEMYQ 681
GR R P G+ F R+ GR++CD+ E+ +C+++ L+E+ Q
Sbjct: 661 KIGRLKRSNMPKLGGRSG-----FGERNATCGRMICDV--EISAKELIRCKSYHLSELVQ 713
Query: 682 VSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEVAFRIQILSLTKQLTNLA 741
ER + + + +Y E SQ+L L +++ ++ + +L L Q+TN+A
Sbjct: 714 QILKTERVVIPMENIQNMYSES-SQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIA 772
Query: 742 GNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEPQVSS--- 798
GN +TL G R+ RNE++LLH F N+YIVPDK+ + Q + ++ ++ +
Sbjct: 773 GNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKK 832
Query: 799 --KKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDR---------NP 847
KK Y GGLV +P+ G + +IL++DFNSLYPSIIQEFNICFTTV R
Sbjct: 833 GRKKGAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTED 892
Query: 848 QDNEELPDVPSREKSRGVLPRLLANLVQRRREVKNLMKTEN-DASKKAQYDIRQQALKLT 906
+ E++P++P G+LPR + LV+RR++VK LMK ++ + QYDIRQ+ALKLT
Sbjct: 893 GEQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLT 952
Query: 907 ANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESLGLTVVYGDTDSVMISTGC 966
ANSMYGCLG+ SRFYAKPLA LVT KGREILM+T+++ + + L V+YGDTDS+MI+T
Sbjct: 953 ANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNS 1012
Query: 967 DNYMDAIKIGENFKKLVNERYSLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTL 1026
N + K+G K VN+ Y LLEIDID +F V N T
Sbjct: 1013 TNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQ 1072
Query: 1027 EVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYAYMEEIRQKVENNEIRMDK 1086
E+KGLD+ RR++C L+K+ V+ +LSD+ ++ ++ I + EI + V N + + +
Sbjct: 1073 ELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQ 1132
Query: 1087 YKINTRLSKDPKSYPGGKNMPAVQVALRMR-EAGRVVKAGSVITFVITKGXXXXXXXXXX 1145
++IN L+KDP+ YP K++P V VAL + + GR VKAG +++VI +
Sbjct: 1133 FEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQ-------DGSN 1185
Query: 1146 ANVAERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLERIESFDIIRLSEALGLDSR 1205
++RA A E + K++ L D YYL +QI V R+ E I+ D + ++ LGLD
Sbjct: 1186 LTASQRAYA-PEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPT 1244
Query: 1206 KYINRGGANGELNGRGMDTLQPLETTISDEERFRDSVPLELTCPNCDTKFVYGGIVASKE 1265
++ E N D L ++DEE++RD + CP C T+ +Y +
Sbjct: 1245 QFRVHHYHKDEEN----DALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSG 1300
Query: 1266 YRFVYSGIQCSNCNHIMTP----IQVTSQLERIIRAHISLYYAGWVACDDSTCGNITRQI 1321
S +CSN + +P +Q++++L IR I YY GW+ C++ TC N TR +
Sbjct: 1301 TDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHL 1360
Query: 1322 SVFGKRC--LLDGC-TGVMSYKYSDKQLYNQMLYFQSLFDLQKNKLQTLKPLYHSGDSNA 1378
+ R L C + +YSDK LY Q+ +++ +FD + L+ L + +
Sbjct: 1361 PLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAE----CALEKLTTDHEKDK 1416
Query: 1379 PEKSLSHSEVQALAEQNRLLFEVSKQVVEKYLSDCGRAYVNMGSIF 1424
+K +V L + +L K E++LS G + VN+ +F
Sbjct: 1417 LKKQFFTPKV--LQDYRKL-----KNTAEQFLSRSGYSEVNLSKLF 1455
>7300763 [L] KOG0970 DNA polymerase alpha catalytic subunit
Length = 1472
Score = 554 bits (1428), Expect = e-157
Identities = 438/1454 (30%), Positives = 703/1454 (48%), Gaps = 156/1454 (10%)
Query: 7 LELLKKLQKARNNKSNRDVLDEQLEEENVYDLIDEDQYRSKKRQELLRDDFVEDDDGSGY 66
+E L++L+ +N D +D+ VYD++DE +Y +K+ QE DD++E+D G+GY
Sbjct: 24 MERLRQLKGTKNKCKVEDQVDD------VYDVVDEREY-AKRAQEKYGDDWIEED-GTGY 75
Query: 67 VDRGVDEWDQSQEFYSDEDDGVDAK--------SGKKRNKTSKNNKGKDTISDIIKQQNV 118
+ D ++ E+ E+D D+K S K+ + K GK +I ++ V
Sbjct: 76 AEDLRDFFEDEDEYSDGEEDRKDSKKKKGVAPNSKKRPRENEKPVTGKASIKNLFSNA-V 134
Query: 119 KRKMTMPTEKPKKVSLAEFDDILSEFDAEP---------LVKKPKLTISRKQPANTTPMN 169
+KM + T LA DIL E EP ++ K++++ ++
Sbjct: 135 PKKMDVKTSVKDDDILA---DILGEIKEEPAATSEKAEKVIAPAKISVTSRKFDAAAAKE 191
Query: 170 YKHPQVDTSPLKGKDVVPFKADSVNPIDCDSMEEDHDIESLLNDVASSPSMSKQKTYQXX 229
Y + ++ ++ ++ +A S N + ++ + + SSP++ K+ +
Sbjct: 192 YMNSFLNNIKVQEQERKKAEASSDNEMLERILKPKAAVPNTKVAFFSSPTIKKEPMPEKT 251
Query: 230 XXXXXXXXXIHFGRKKFKSI----------ATQRQMNIS-AQTAPLTSSPTYVTAPNTPL 278
F + TQ+ +S +TA +S + V + P
Sbjct: 252 PAKKATEDPFSDNEMDFSCLDDDENQFDVEKTQQTEKVSQTKTAAEKTSQSKVAEKSAPK 311
Query: 279 STSTGSTQATES--ISGSLRQ----------------RIPKEDVVDAETGSFNFFWT--- 317
+TGS + +ES IS L ++ + ++ ++W
Sbjct: 312 KETTGSPKESESEDISRLLNNWESICQMDDDFEKSVLTTEQDSTISSDQQLRFWYWEAYE 371
Query: 318 DFTEVNSSLILFGKVKTRKNQVVSAMAQINGFNRELYFLP-------------KEGKTAS 364
D ++ + LFG+ K S ++ NR LY LP K+ T +
Sbjct: 372 DPVKMPGEVFLFGRTADGK----SVCLRVQNINRVLYLLPRQFLLDPISKEPTKQKVTVA 427
Query: 365 DVHQEIVPLLLDKYGLQSLRAKPETKKYAFELPGI--PHEAEYLKVLLPYDTPKCKSITI 422
D+++E + ++ L+ R++ TK +A GI P +YL+V YD K +
Sbjct: 428 DIYKEFDSEVANQLKLEFFRSRKVTKSFAHHAIGIEVPQSCDYLEV--HYDGKKPLP-NL 484
Query: 423 PAELEGDTFSHVFGGNQNLFESFVVQRKIMGPCWLKISDGDFDAVQGASHCAIEVQIDSP 482
A+ + ++ +H+FG N E F++ RKI GPCWL+++ G + S C EV + P
Sbjct: 485 SADKKYNSIAHIFGATTNALERFLLDRKIKGPCWLQVT-GFKVSPTPMSWCNTEVTLTEP 543
Query: 483 NHISATNEKSSPS----LNCISLSIQTVMNAKENKQEIVAISMAVFKNLSQDSSIPQNLK 538
++ +K P+ L +SL+++T MN K ++ EI ISM D PQ
Sbjct: 544 KNVELVQDKGKPAPPPPLTLLSLNVRTSMNPKTSRNEICMISMLTHNRFHIDRPAPQPAF 603
Query: 539 PNEIVTLVRPPQGSTFPPLLGPKSKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGH 598
+ L RP S +P L + K S V ++E+ LL+ F A + D D+I+
Sbjct: 604 NRHMCALTRPAVVS-WPLDLNFEMAKYKSTTVHKHDSERALLSWFLAQYQKIDADLIVTF 662
Query: 599 RLEGVILDVLAHRAYELNIPQFSVFGR-RLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLC 657
L+V+ + L IPQ+S GR RL +++ + +H F GR++C
Sbjct: 663 DSMDCQLNVITDQIVALKIPQWSRMGRLRLSQSFGKRLLEH------------FVGRMVC 710
Query: 658 DISNEMGQSLTPKCQNWELNEMY-QVSCGIERKSLEINY--LNPIYQEDESQMLLALGEN 714
D+ + + + ++++L + QV E + +E+N L +Y++ ES L
Sbjct: 711 DVKRSAEECI--RARSYDLQTLCKQVLKLKESERMEVNADDLLEMYEKGESITKLISLTM 768
Query: 715 IENSIITAEVAFRIQILSLTKQLTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPD 774
+NS + + + I+ L Q+TN+ GN +TL G R+ RNE++LLH F+ +YIVPD
Sbjct: 769 QDNSYLL-RLMCELNIMPLALQITNICGNTMTRTLQGGRSERNEFLLLHAFHEKNYIVPD 827
Query: 775 KET---RQMKQDRQQKNEDPMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPS 831
K+ R D + KK+ Y GGLV EP +GL++ Y+L+MDFNSLYPS
Sbjct: 828 KKPVSKRSGAGDTDATLSGADATMQTKKKAAYAGGLVLEPMRGLYEKYVLLMDFNSLYPS 887
Query: 832 IIQEFNICFTTVDRNPQDNEELPDVPSREKSRGVLPRLLANLVQRRREVKNLMKTENDAS 891
IIQE+NICFTTV + P D +ELP +P + G+LP L LV+ R+EVK LM + +
Sbjct: 888 IIQEYNICFTTVQQ-PVDADELPTLPDSKTEPGILPLQLKRLVESRKEVKKLMAAPDLSP 946
Query: 892 K-KAQYDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESLGL 950
+ + QY IRQ ALKLTANSMYGCLG+ +SRF+A+ LA LVT+KGREIL NT+QL + +
Sbjct: 947 ELQMQYHIRQMALKLTANSMYGCLGFAHSRFFAQHLAALVTHKGREILTNTQQLVQKMNY 1006
Query: 951 TVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERYSLLEIDIDNIFXXXXXXXXXXXX 1010
VVYGDTDS+MI+T +Y KIG N K+ VN+ Y LE+DID +F
Sbjct: 1007 DVVYGDTDSLMINTNITDYDQVYKIGHNIKQSVNKLYKQLELDIDGVFGCLLLLKKKKYA 1066
Query: 1011 XXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYAYM 1070
++ D + N + E KGLD+ RR++ L+ V VL+ +LS+K E L ++A +
Sbjct: 1067 AIKLSKDSKGNLRREQEHKGLDIVRRDWSQLAVMVGKAVLDEVLSEKPLEEKLDAVHAQL 1126
Query: 1071 EEIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRM-REAGRVVKAGSVIT 1129
E+I+ ++ + + + I +L++ P+ Y ++P VQVALRM RE R K G +
Sbjct: 1127 EKIKTQIAEGVVPLPLFVITKQLTRTPQEYANSASLPHVQVALRMNRERNRRYKKGDM-- 1184
Query: 1130 FVITKGXXXXXXXXXXANVAERARALNEVMNKKN-GLKPDPVYYLGKQIFSPVQRLLERI 1188
RA L+E+ ++ L+ D YYLG QI V R++E +
Sbjct: 1185 ---------------------RAYHLDELKTSEDKKLQLDTNYYLGHQIHPVVTRMVEVL 1223
Query: 1189 ESFDIIRLSEALGLDSRKYINRGGANGELNGRGMDTLQPLETTISDEERFRDSVPLELTC 1248
E D R++E LG+D K+ N + L+TT+ + +R P C
Sbjct: 1224 EGTDASRIAECLGMDPTKFRQNAQRTQRENTEQSEGESLLKTTL---QLYRLCEPFRFQC 1280
Query: 1249 PNCDTKFVYGGIV---ASKEYRFVYSGIQCSNCNHIMTPIQ----VTSQLERIIRAHISL 1301
C T+ + S + V QC+ PIQ V +QL+ +R ++
Sbjct: 1281 VTCKTEQLMASAYRPGPSNSHIAVLQ--QCAKSECQTAPIQYLASVRNQLQLSMRQYVQR 1338
Query: 1302 YYAGWVACDDSTCGNITRQISVFGK--RCLLDGC-TGVMSYKYSDKQLYNQMLYFQSLFD 1358
+Y W+ CD C TR S+ K R L C +G + +Y+++ LYNQ+ Y + +FD
Sbjct: 1339 FYKNWLVCDHPDCNFNTRTHSLRKKSHRPLCQKCRSGSLLRQYTERDLYNQLCYLRFMFD 1398
Query: 1359 LQKNKLQ---TLKP 1369
L K LQ TL P
Sbjct: 1399 LGKQTLQQKPTLTP 1412
>CE26106 [L] KOG0970 DNA polymerase alpha catalytic subunit
Length = 1443
Score = 548 bits (1412), Expect = e-155
Identities = 424/1419 (29%), Positives = 707/1419 (48%), Gaps = 141/1419 (9%)
Query: 6 KLELLKKLQKARNNKSNRDVLDEQLEEENVYDLIDEDQYRS--KKRQELLRDDFVEDDDG 63
K + L +++ + +S +L+ E+VYD +D+D+Y KRQ +D+F+ DDDG
Sbjct: 25 KSKELSAIEQLKLARSTGKAYRPELDVEDVYDTVDDDEYEKIVAKRQ---KDNFIVDDDG 81
Query: 64 SGYVDRGVDEWDQSQEFYSDEDDGVDAKSGKKRNKTSKNNKGKDTISDIIKQQNVKRKMT 123
GYVD GVD D ++ Y+ ++ S KK K K +K K + + T
Sbjct: 82 MGYVDNGVDFEDDYEDDYAPSSSK-NSNSSKKGEKKPKKDKKKGGLHAFLS--------T 132
Query: 124 MPTEKP--KKVSLAEFDD------ILSEFDA--EPLVKKPKLTISRKQPANTTPMNYKHP 173
T+KP + V AEFDD +L + + E +KPK T PAN +K
Sbjct: 133 TSTKKPIDESVVKAEFDDDEEVKNMLEQLGSSDEEAEEKPKAT-----PANP----FKRG 183
Query: 174 QVDTSPLKGKDVVP------FKADSVNPIDCD-----SMEEDHDIESLLNDVASSPSMSK 222
+ SP + P K ++ + ++ED D + +SP S
Sbjct: 184 RKFDSPSGSDSLAPRPIAKKAKREATGLAEHKFQRHVKVDEDEDYGIPDDYPVASPVTSP 243
Query: 223 QKTYQXXXXXXXXXXXIHFGRKKFKSIATQRQMNISAQTAPL------TSSPTYVTAPNT 276
KT + I + K + T+ + A T + +
Sbjct: 244 VKTEKMAEVEAPTAPAIQKIEETVK-METEHLEEVEDSLAKFRVIEDWTGGSSSQEDEDV 302
Query: 277 PLSTSTGSTQATESISGSLRQRIPKEDVVDAETGSFNFFWTDFTE----VNSSLILFGKV 332
+ TGS +A ++ G D T + +W D E N ++ LFGKV
Sbjct: 303 KVEVKTGS-EAFYTMGGE-----------DNTTKAIRMYWIDAYEDVHKANGTVYLFGKV 350
Query: 333 KTRKNQVVSAMAQINGFNRELYFLPK-------EGKTASDVHQEIVPLLLDKYGLQSLRA 385
KT N + + R++YF+P+ E + +++H+EI +L +K+ +
Sbjct: 351 KTSGNAWETCSIVVKNICRKVYFMPRTKNLSTGEESSLAELHKEIGDVLRNKFNTHEFKC 410
Query: 386 KPETKKYAFELP---GIPHEAEYLKVLLPYDTPKCKSITIPAELEGDTFSHVFGGNQNLF 442
K K+ + G ++ ++VL P + K +P++L+GDTFS+ F +
Sbjct: 411 KMVEKELIRDESFGYGCGTKSPLMEVLYPAEKGK-----LPSDLKGDTFSNTFNTSVTPL 465
Query: 443 ESFVVQRKIMGPCWLKISDGDFDAVQGASHCAIEVQIDSPNHISATNEKSS----PSLNC 498
E ++++K MGP W+++ + D S+C E ++D + +SS P++
Sbjct: 466 ERLLIEKKFMGPGWIELYNYS-DPKAKTSNCKYEFEVDMEKMRNIKYLESSDAPPPTIKL 524
Query: 499 ISLSIQTVMNAKENKQEIVAISMAVFK--NLSQDSSIPQNLKPNEIVTLVRPPQGSTFPP 556
++L++ T +N +++ EI ISM +L+ S ++LKP +VT +PP GS
Sbjct: 525 LALNVVTTLNDRKDN-EICMISMLFNPKCDLAHPSGDSKDLKPKCLVT--KPPGGSLPYD 581
Query: 557 LLGPKSKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELN 616
+ ++LS V+ NEK LL F A++ ++PD+I+GH L I +L R +L
Sbjct: 582 IQKRLETEKLSKFVKSVANEKALLTLFLAMINEDEPDMIVGHDLSATIA-LLVSRLEKLK 640
Query: 617 IPQFSVFGRRLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLCDISNEMGQSLTPKCQNWEL 676
+P +S R R K G + + L AGR++ D +++ K ++++L
Sbjct: 641 LPNWSRISRLKRSINIGKIGHSKSGQWE-----LTAGRMMLD--SKLAAMELVKSRSFDL 693
Query: 677 NEMYQVSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEVAFRIQILSLTKQ 736
E+ Q G ER+ + N + +Y D ++ + + + +++ + R+ L L Q
Sbjct: 694 TELSQQILGAERREIYANEIPQLYV-DSKDLISLINWSWNDLLLSLRIVVRLNALPLYIQ 752
Query: 737 LTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEPQV 796
++ + G +T+ G RA RNEY+LLH F + D I PDK + +++K E +
Sbjct: 753 ISQIVGGIASRTMMGGRAERNEYLLLHAFEKADLIAPDKYNSS--ESKKKKEESQEGDEK 810
Query: 797 SSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDRNPQDNEELPDV 856
S K++Y GGLV EP+KGL++ IL++DFNSLYPSIIQE+NIC+TT++ + +E+L V
Sbjct: 811 KSGKAQYSGGLVLEPKKGLYETLILLLDFNSLYPSIIQEYNICYTTLEYSKDSDEQL-SV 869
Query: 857 PSREKSRGVLPRLLANLVQRRREVKNLMKTENDASKKAQYDIRQQALKLTANSMYGCLGY 916
P GVLPR + LV+ RR+VK+LMK+E + +KK Q DIRQ ALKLTANSMYGCLG+
Sbjct: 870 PQSTDIEGVLPREIRKLVECRRDVKSLMKSERNEAKKKQMDIRQMALKLTANSMYGCLGF 929
Query: 917 VNSRFYAKPLAMLVTNKGREILMNTRQLAESLGLTVVYGDTDSVMISTGCDNYMDAIKIG 976
SRFYAKPLA LVT KGREILM+++ L E +G +VVYGDTDS+MI+T + + A K+G
Sbjct: 930 QYSRFYAKPLAALVTAKGREILMHSKDLVEKMGYSVVYGDTDSIMINTNSVDLVAAKKLG 989
Query: 977 ENFKKLVNERYSLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRR 1036
KK VN+ + LLE+D+D +F + D + K E+KGLD+ RR
Sbjct: 990 NEIKKAVNKCHRLLELDLDGVFKRMLLLKKKKYAALTINPDTKVEAK---ELKGLDIVRR 1046
Query: 1037 EFCPLSKEVSTRVLN-ILLSDKDSESALQEIYAYMEEIRQKVENNEIRMDKYKINTRLSK 1095
++ L+KE T V++ IL + + + I + EIR K+++ + ++ ++I+ +L++
Sbjct: 1047 DWSQLAKETGTAVVDKILDASLTRDEMVSSIDDLLREIRAKLDSGTVPLEMFQISKQLTR 1106
Query: 1096 DPKSYPGGKNMPAVQVALRMREAGRV-VKAGSVITFVITKGXXXXXXXXXXANVAERARA 1154
+P+ Y K VA R+ ++G+ ++ ++ +VI + N A +
Sbjct: 1107 NPEQYADVKAQCHAAVAQRLNKSGKFNLRHNDIVEYVICEDGTD--------NPATQRAY 1158
Query: 1155 LNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLERIESFDIIRLSEALGLDSRKYINRGGAN 1214
M + + LK D +YYL +QI V RL+E IE D +R++E LGLDS Y R A
Sbjct: 1159 HRTEMAENSALKIDLLYYLAQQIHPVVSRLVEPIEETDAVRIAENLGLDSTNY--RRAAA 1216
Query: 1215 GELNGRGMDTLQPLETTISDEERFRDSVPLELTCP--NCDTKFV----YGGIVASKEYRF 1268
+ + R + E +E + + + CP C V + + + R
Sbjct: 1217 AQASQRAAE-----EDCAWHQENYDLCEGIHVICPLDGCGHSNVIRETFDCVTDASSPRL 1271
Query: 1269 VYSGIQCSNCNHIMT----PIQVTSQLERIIRAHISLYYAGWVACDDSTCGNITRQISV- 1323
++SG C+ C + +Q++R + ++ ++ CD+ TC TR ++
Sbjct: 1272 LFSG--CAQCQGSWDLQEHQAVIGNQVDRQMSEFVARHHLAAFKCDEPTCEFKTRVQTMK 1329
Query: 1324 ---FGKRCLLDGCTGVMSYKYSDKQLYNQMLYFQSLFDL 1359
G C+ TGV+ +Y+ KQL++Q ++F+++ D+
Sbjct: 1330 WCREGLECIRCS-TGVLRREYTSKQLFDQQMFFRTILDV 1367
>At5g67100 [L] KOG0970 DNA polymerase alpha catalytic subunit
Length = 1492
Score = 546 bits (1406), Expect = e-154
Identities = 447/1490 (30%), Positives = 712/1490 (47%), Gaps = 200/1490 (13%)
Query: 2 SNANKLELLKKLQKARNNKSNRDVLDEQLEEENVYDLIDEDQYRS--KKRQELLRDDFVE 59
S + LE LK +++ ++ D +L++ ++D +D+++Y + +R+E R VE
Sbjct: 21 SRKDTLERLKAIRQGGIRSASGGGYDIRLQKP-IFDTVDDEEYDALVSRRREEARGFVVE 79
Query: 60 DDDGS--GYVDRGVDE-WDQSQ--EFYSDEDDGVDAKSGKKRNKTSKNNKGKD-TISDII 113
D +G GY+D G +E W + E + DDG G+ + K KGK+ T +
Sbjct: 80 DGEGGDLGYLDEGEEEDWSKPSGPESTDESDDG-----GRFSGRLKKKKKGKEQTQQPQV 134
Query: 114 KQQN--VKRKMTMPTE-------------KPKKVSLAEFDDILSEFDAE--PLVKKPKLT 156
K+ N +K T+ E K K+ A+++ IL E A+ P K
Sbjct: 135 KKVNPALKAAATITGEGRLSSMFTSSSFKKVKETDKAQYEGILDEIIAQVTPDESDRKKH 194
Query: 157 ISRKQPANTTPMNYKHPQV----DTSPLKGKDVVP--FKADSVNPIDCDSMEEDHDIESL 210
RK P +K+ ++ + +K + P ++ DSV+ +D + M+E+ ES
Sbjct: 195 TRRKLPGTVPVTIFKNKKLFSVASSMGMKESEPTPSTYEGDSVS-MDNELMKEEDMKES- 252
Query: 211 LNDVASSPSMSKQKTYQXXXXXXXXXXXIHFGRKKFKSIATQRQMNISAQTAPLTSSPTY 270
+V S +M G K + T+ + + + ++
Sbjct: 253 --EVIPSETME----------LLGSDIVKEDGSNKIRK--TEVKSELGVKEVFTLNATID 298
Query: 271 VTAPNTPLSTSTGSTQATESIS-------GSLRQRIPKEDVVDAETGSFNFFWTD----- 318
+ ++ LS + G +A + GS + + D+ DA+ GS FF D
Sbjct: 299 MKEKDSALSATAGWKEAMGKVGTENGALLGSSSEGKTEFDL-DAD-GSLRFFILDAYEEA 356
Query: 319 FTEVNSSLILFGKVKTRKNQVVSAMAQINGFNRELYFLPKEG------------------ 360
F ++ LFGKVK + S + R +Y +P +
Sbjct: 357 FGASMGTIYLFGKVKMG-DTYKSCCVVVKNIQRCVYAIPNDSIFPSHELIMLEQEVKDSR 415
Query: 361 -----------KTASDVHQEIVPLLLDKYGLQSLRAKPETKKYAFELPGIPHEAEY-LKV 408
+ AS + EI LL + + + P + YAFE P +P +Y LK+
Sbjct: 416 LSPESFRGKLHEMASKLKNEIAQELL-QLNVSNFSMAPVKRNYAFERPDVPAGEQYVLKI 474
Query: 409 LLPYDTPKCKSITIPAELEGDTFSHVFGGNQNLFESFVVQRKIMGPCWLKISD-GDFDAV 467
+ K +P +L+G++FS + G + + E F+++RKIMGPCWLKIS
Sbjct: 475 NYSF-----KDRPLPEDLKGESFSALLGSHTSALEHFILKRKIMGPCWLKISSFSTCSPS 529
Query: 468 QGASHCAIEVQIDSPNHIS--ATNEKS-SPSLNCISLSIQTVMNAKENKQEIVAISMAVF 524
+G S C EV + SP I+ + EK P +++++T++N K+N EIV+ S+ F
Sbjct: 530 EGVSWCKFEVTVQSPKDITILVSEEKVVHPPAVVTAINLKTIVNEKQNISEIVSASVLCF 589
Query: 525 KNLSQDSSIPQNLKPNEIV----TLVRPPQGSTFP----PLLGPKSKKELSGNVRLFNNE 576
N D +P + + T+VR P+G+ +P + ++ K + + N+E
Sbjct: 590 HNAKIDVPMPAPERKRSGILSHFTVVRNPEGTGYPIGWKKEVSDRNSKNGCNVLSIENSE 649
Query: 577 KTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNIPQ--FSVFGRRLRKAWPDK 634
+ LLN L D D+++GH + G LDVL RA + +S GR R P
Sbjct: 650 RALLNRLFLELNKLDSDILVGHNISGFDLDVLLQRAQACKVQSSMWSKIGRLKRSFMPKL 709
Query: 635 FGKHN-NSMTQFIVRDLFAGRLLCDISNEMGQSLTPKCQNWELNEMYQVSCGIERKSLEI 693
G N S + AGRLLCD ++ K ++ L ++ + +RK +
Sbjct: 710 KGNSNYGSGATPGLMSCIAGRLLCD--TDLCSRDLLKEVSYSLTDLSKTQLNRDRKEIAP 767
Query: 694 NYLNPIYQEDESQM-LLALGENIENSIITAEVAFRIQILSLTKQLTNLAGNGWRQTLGGT 752
N + ++Q ++ + L+ GE ++ ++ E+ F + +L LT QLTN++GN W +TL G
Sbjct: 768 NDIPKMFQSSKTLVELIECGET--DAWLSMELMFHLSVLPLTLQLTNISGNLWGKTLQGA 825
Query: 753 RAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNE---------------------DP 791
RA R EY LLH F+ +I+PDK +++MK+ + K DP
Sbjct: 826 RAQRIEYYLLHTFHSKKFILPDKISQRMKEIKSSKRRMDYAPEDRNVDELDADLTLENDP 885
Query: 792 MEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDRNPQDNE 851
+ + K Y GGLV EP++GL+ Y+L++DFNSLYPSIIQE+NICFTT+ P+ +
Sbjct: 886 SKGSKTKKGPAYAGGLVLEPKRGLYDKYVLLLDFNSLYPSIIQEYNICFTTI---PRSED 942
Query: 852 ELPDVPSREKSRGVLPRLLANLVQRRREVKNLMKTENDASKKAQYDIRQQALKLTANSMY 911
+P +PS ++ G+LP+L+ +LV R+ VK MK E K + DIRQQALKLTANSMY
Sbjct: 943 GVPRLPS-SQTPGILPKLMEHLVSIRKSVKLKMKKET-GLKYWELDIRQQALKLTANSMY 1000
Query: 912 GCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAES-LGLTVVYGDTDSVMISTGCDNYM 970
GCLG+ NSRFYAKPLA L+T +GR+IL T L ++ L L V+YGDTDS+MI +G D+
Sbjct: 1001 GCLGFSNSRFYAKPLAELITLQGRDILQRTVDLVQNHLNLEVIYGDTDSIMIHSGLDDIE 1060
Query: 971 DAIKIGENFKKLVNERYSLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKG 1030
+ I + VN++Y L+ID D I+ + F K +E KG
Sbjct: 1061 EVKAIKSKVIQEVNKKYRCLKIDCDGIYKRMLLLRKKKYAAVKLQF-KDGKPCEDIERKG 1119
Query: 1031 LDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYAYMEEIRQKVENNEIRMDKYKIN 1090
+DM RR++ LSKE+ L+ +L E ++ I+ + +I++++ N ++ ++KY I
Sbjct: 1120 VDMVRRDWSLLSKEIGDLCLSKILYGGSCEDVVEAIHNELMKIKEEMRNGQVALEKYVIT 1179
Query: 1091 TRLSKDPKSYPGGKNMPAVQVALRMREAG--RVVKAGSVITFVITKGXXXXXXXXXXANV 1148
L+K P +YP K+ P VQVALRMR+ G A + ++I A +
Sbjct: 1180 KTLTKPPAAYPDSKSQPHVQVALRMRQRGYKEGFNAKDTVPYIICY-EQGNASSASSAGI 1238
Query: 1149 AERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLERIESFDIIRLSEALGLDSRKYI 1208
AERAR +EV ++ + D YYL +QI V RL I+ RL+E LGLD KY
Sbjct: 1239 AERARHPDEVKSEGSRWLVDIDYYLAQQIHPVVSRLCAEIQGTSPERLAECLGLDPSKYR 1298
Query: 1209 NRGGANGELNGRGMDTLQPLETTISDEERFRDSVP----------LELTCPNCDTKFVYG 1258
++ + D L SDEE + + P L+L CP C
Sbjct: 1299 SKSN-----DATSSDPSTSLLFATSDEESKKPATPETEESDSTFWLKLHCPKC------- 1346
Query: 1259 GIVASKEYRFVYSGIQCSNCNHIMTPIQVTSQLERIIRAHISLYYAGWVACDDSTCGNIT 1318
Q + I++P + +Q++R I +S+YY G + C+D +C + T
Sbjct: 1347 ---------------QQEDSTGIISPAMIANQVKRQIDGFVSMYYKGIMVCEDESCKHTT 1391
Query: 1319 R--QISVFGKR-----C-LLDGCTGVMSYKYSDKQLYNQMLYFQSLFDLQ 1360
R + G+R C C G + KY++ LY Q+ YF + D Q
Sbjct: 1392 RSPNFRLLGERERGTVCPNYPNCNGTLLRKYTEADLYKQLSYFCHILDTQ 1441
>ECU05g0990 [L] KOG0970 DNA polymerase alpha catalytic subunit
Length = 956
Score = 268 bits (684), Expect = 6e-71
Identities = 172/530 (32%), Positives = 278/530 (52%), Gaps = 74/530 (13%)
Query: 711 LGENIENSIITAEVAFRI----QILSLTKQLTNLAGNGWRQTLGGTRAGRNEYILLHEFN 766
LG + I +E +I + L L+K+++ ++G +TL RA R EY LLHE
Sbjct: 327 LGYQLRRLISESEAILQIFQATEALDLSKEMSEVSGYILNRTLQNLRAERIEYTLLHELY 386
Query: 767 RNDYIVPDKETRQMKQDRQQKNEDPMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFN 826
++ P P VS ++ KY GGLV P+ G +++ +L++DFN
Sbjct: 387 ARGFLFP--------------------PTVSRREVKYSGGLVLPPQTGFYEDLVLLLDFN 426
Query: 827 SLYPSIIQEFNICFTTV---DRNPQDN---EELPDV--PSREKSRGVLPRLLANLVQRRR 878
SLYPSIIQEFN+CF+T+ DR+ N E+L + ++ RG LPR+L V+RR+
Sbjct: 427 SLYPSIIQEFNVCFSTIGMFDRSISGNMSSEQLVRLTEDAKNSERGFLPRILEGFVRRRK 486
Query: 879 EVKNLMKTENDASKKAQYDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREIL 938
VK+L+K + DIRQ+ALKLTANS+YGCLG+V SRF +A +T+KGR++L
Sbjct: 487 AVKDLLKQGGTPEETKALDIRQKALKLTANSIYGCLGFVGSRFCNYTMAAYITSKGRDLL 546
Query: 939 MNTRQLAE-SLGLTVVYGDTDSVMISTGC----DNYMDAIKIGENFKKLVNERYSLLEID 993
+ +++AE G+ ++YGDTDSVM+ TG NY A+++ + +N RY +EI+
Sbjct: 547 LEAKRIAEGECGVRIIYGDTDSVMVHTGLAGKKSNYTKALELSRRLQDAINSRYKKIEIE 606
Query: 994 IDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNIL 1053
+D +F +T D K +E KGLD+ R++FC +S+++ VL +L
Sbjct: 607 VDKVFKKLLLYKKKRYAGLYMTDD----GKGRIEYKGLDLVRKDFCEVSRKICRIVLELL 662
Query: 1054 LSDKDSESALQEIY-----------------AYMEEIRQKVENNE-IRMDKYKINTRLSK 1095
L+D + + Y A +E+R+ + E I ++ I+ LSK
Sbjct: 663 LADCEDPETYRRFYEGEPKMVLNDGSIKIREAVYDELRKVSSDLEGIPAREFVIHNTLSK 722
Query: 1096 DPKSYPGGKNMPAVQVALRMREAGRVVKAGSVITFVITKGXXXXXXXXXXANVAERARAL 1155
P+SY +P V +ALR++E G + G V+ +VI KG + +A+
Sbjct: 723 APESYDACAALPHVSLALRLKERGMKFEQGDVVCYVIGKG--------------DPGQAI 768
Query: 1156 NE-VMNKKNGLKPDPVYYLGKQIFSPVQRLLERIESFDIIRLSEALGLDS 1204
++ + D YY+ QI P+ R++ ++ F ++ + G++S
Sbjct: 769 HKRAYHPDEDFAIDYGYYISSQILPPLLRVVGIVKGFHAGKIGKIFGVES 818
>CE09308 [L] KOG0969 DNA polymerase delta catalytic subunit
Length = 1081
Score = 181 bits (458), Expect = 1e-44
Identities = 178/785 (22%), Positives = 336/785 (42%), Gaps = 81/785 (10%)
Query: 433 HVFGGNQNLFESFVVQRKIMGPCWLKISDGDFDAVQGA---SHCAIEVQIDSPN---HIS 486
+++ N N+ F+ + I+G W++I G + + S C IEV + N H S
Sbjct: 211 NLYESNINVIVMFLAKTNIVGCGWIEIPAGKCRILSNSEKSSRCQIEVTVPVKNLIVHES 270
Query: 487 ATNEKSSPSLNCISLSIQTVMNAKENKQEIVAISMAVFKNLSQDSSIPQNLKPNEIVTLV 546
+ +SL I+ + + E + + NL + + N V
Sbjct: 271 DGEWAGIAPIRTLSLDIECI-GRRGVFPEAIKDPIIQIANLVKIEGEAEPFVRNCFVL-- 327
Query: 547 RPPQGSTFPPLLGPKSKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILD 606
T P++G N+ NEK LL + ++ DPD+I G+ + L
Sbjct: 328 -----GTCAPVVG--------SNIIQCVNEKVLLEKWAEFVREVDPDIITGYNILNFDLP 374
Query: 607 VLAHRAYELNIPQFSVFGRRLRKAWPDKFGK-HNNSMTQFIVRDL-FAGRLLCDISNEMG 664
+ RA L++PQ S GR+ K + + M + + + GR++ D+ +
Sbjct: 375 YILDRAKVLSLPQVSHLGRQKEKGSVVRDAAISSKQMGSRVNKSIDIHGRIIFDVLQVVL 434
Query: 665 QSLTPKCQNWELNEMYQVSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEV 724
+ K +++ LN + +++ +E N + + + DE ++++ + +
Sbjct: 435 RDY--KLRSYTLNSVSYQFLSEQKEDVEHNIIPDLQRGDEQTRRRLAQYCLKDAYLPLRL 492
Query: 725 AFRIQILSLTKQLTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDR 784
++ + ++ + G L + + ++L +N++ +P E
Sbjct: 493 LDKLMSIINYIEMARVTGVPMNFLLTKGQQIKILSMMLRRCKQNNFFLPVIEAN------ 546
Query: 785 QQKNEDPMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVD 844
S Y+G V +P +G + I +DF SLYPSI+ N+C+TT+
Sbjct: 547 ------------SGDGEGYEGATVIDPIRGFYNEPIATLDFASLYPSIMIAHNLCYTTLL 594
Query: 845 RNPQ--DNEELPDVPS------REKSRGVLPRLLANLVQRRREVKNLMKTENDASKKAQY 896
++PQ +NE+ PS + K RG+LP +L +++ R+ KN MK E D K+ Y
Sbjct: 595 KSPQGVENEDYIRTPSGQYFATKSKRRGLLPEILEDILAARKRAKNDMKNEKDEFKRMVY 654
Query: 897 DIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESL-------- 948
+ RQ ALK++ANS+YG G + ++ VT GR+++ T+ E +
Sbjct: 655 NGRQLALKISANSVYGFTGATVGKLPCLEISQSVTAFGRKMIDMTKLEVERIYKKGALDG 714
Query: 949 ----GLTVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERYS-LLEIDIDNIFXXXXX 1003
V+YGDTDSVM+ G + A++IG + K V++ ++ ++++ + ++
Sbjct: 715 KCPADAKVIYGDTDSVMVKFGVETVAQAMEIGLDAAKEVSKIFTPPIKLEFEKVYSPYLL 774
Query: 1004 XXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESAL 1063
T +++ ++ KGL+ RR+ CPL +V L LL ++D +SAL
Sbjct: 775 INKKRYAGLYFTKPDVHDK---MDCKGLETVRRDNCPLVAKVLGVCLEKLLIERDQQSAL 831
Query: 1064 QEIYAYMEEIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRMREAGRVVK 1123
+ + + N+I + I+ L+K Y + + ++ R+AG +
Sbjct: 832 D----FAKRTISDLLCNKIDISLLIISKELTKSGDKYQAKQAHVELAARMKKRDAGSAPR 887
Query: 1124 AGSVITFVITKGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQR 1183
G + +V NV RA + +N + D +YL Q+ P+ R
Sbjct: 888 LGDRVPYVFV---------AAAKNVPAYERAEDPTFVLQNNIPLDTKHYLTNQLAKPLAR 938
Query: 1184 LLERI 1188
+ E I
Sbjct: 939 IFEPI 943
>ECU09g0430 [L] KOG0969 DNA polymerase delta catalytic subunit
Length = 974
Score = 174 bits (441), Expect = 9e-43
Identities = 163/714 (22%), Positives = 304/714 (41%), Gaps = 73/714 (10%)
Query: 564 KELSG----NVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNIPQ 619
KE +G NV + EK LL + DPDVI+G+ ++G + + R L I
Sbjct: 241 KETTGIPGVNVHWYETEKELLESWKKYFMELDPDVIVGYNVKGFDIPYILSRGEILGIES 300
Query: 620 FSVFGRRLRKAWPDKFGKHNNSMTQFIVRDL-FAGRLLCDISNEMGQSLTPKCQNWELNE 678
FSV GR +KA +N ++ GRL+ D+ + + K +++ LN
Sbjct: 301 FSVLGRSRKKARTRDTTMSSNMFGSITTTEVEIDGRLIIDMMVVIRRDF--KLRSYSLNS 358
Query: 679 MYQVSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEVAFRIQILSLTKQLT 738
+ +++ + + + + +++ + ++++ + + +L +L+
Sbjct: 359 VSIHFLKEQKEDVPYSSIGELQSKNKDTRRRIASYCLRDTVLPLRLFNTLNVLINYTELS 418
Query: 739 NLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEPQVSS 798
+ G A + ++ ++ D+++PD DP E
Sbjct: 419 RVTGTPIEYFFTRGMAIKIFTLVYRAASKEDFMIPDI--------------DPFE----- 459
Query: 799 KKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDRNPQ----DNEELP 854
++GG V EP KG + + VMDF+SLYPSI+ N+C+TT+ Q + P
Sbjct: 460 SNKTFEGGFVIEPRKGFYNKPVSVMDFSSLYPSIMISHNLCYTTLLTKEQYRILGGTKTP 519
Query: 855 D---VPSREKSRGVLPRLLANLVQRRREVKNLMKTENDASKKAQYDIRQQALKLTANSMY 911
S E+ +G+LPR+L +L+ R+ +K ++ E D++ +A + RQ A KL ANS+Y
Sbjct: 520 TGNYFCSAERKKGLLPRILTDLLTSRKRIKEELEREKDSALRACLNGRQLAFKLCANSLY 579
Query: 912 GCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAE-----SLGLT----VVYGDTDSVMI 962
G G + ++ VT GRE+++ T++L E G T V+YGDTDSVM+
Sbjct: 580 GFTGASRGKLPCFEISQSVTGFGREMIILTKKLIEENFSRKNGYTHDSVVIYGDTDSVMV 639
Query: 963 STGCDNYMDAIKIGENFKKLVNERY-SLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNN 1021
+ K+ + + + ++ + ++ + ++ + + N
Sbjct: 640 DFDEQDIEKVFKMSKEISEFITSKFVKPVSLEFEKVY--YPYLLINKKRYAGLLYSNPEN 697
Query: 1022 EKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYAYMEEIRQKVENNE 1081
+ ++ +G++ RR+ C L KEV VL ++L K+ E A Q ++++ + +
Sbjct: 698 -PSKIDTRGIETVRRDNCRLVKEVVETVLEMILYQKNVEKAKQ----FVKDAVRDLYLGR 752
Query: 1082 IRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRMREAGRVVKAGSVITFVITKGXXXXXX 1141
+ I+ L+K Y + + LR R+ G + +VI +
Sbjct: 753 TDLSLLVISKSLTKAGDKYESKQAHVQLAEKLRKRDESTAPVLGDRVPYVIVR------- 805
Query: 1142 XXXXANVAERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLERIESFDIIRLSEALG 1201
A ++ + V +N L D YY+ +QI P+ R+ E I + + E
Sbjct: 806 --KEKGAAAHEKSEDPVYVLENNLPIDTEYYISQQISKPLSRIFEPI----MDNVQELFR 859
Query: 1202 LDSRKYINRGGANGELNGRGMDTLQPLETTISDEERFRDSVPLELTCPNCDTKF 1255
D + G G +N L+P +T + R + C NC F
Sbjct: 860 GDHTRIAASTGLKGPMN----TFLKPTDTCVGCRAEGR------IICINCVKDF 903
>SPBC336.04 [L] KOG0969 DNA polymerase delta catalytic subunit
Length = 1086
Score = 173 bits (439), Expect = 2e-42
Identities = 190/793 (23%), Positives = 335/793 (41%), Gaps = 103/793 (12%)
Query: 435 FGGNQNLFESFVVQRKIMGPCWLKI--SDGDFDAVQGASHCAIEVQIDSPNHISATNE-- 490
F N F++ ++G W+ + S F S+C IE I+ + IS E
Sbjct: 228 FESNTQYLLRFMIDCDVVGMNWIHLPASKYQFRYQNRVSNCQIEAWINYKDLISLPAEGQ 287
Query: 491 --KSSPSLNCISLSIQTVMNAKENKQEIVAISMAVFKNLSQDSSIPQNLKPNEIVTLVRP 548
K +P L +S I+ A K + D SI ++ IVT
Sbjct: 288 WSKMAP-LRIMSFDIEC----------------AGRKGVFPDPSIDPVIQIASIVTQYGD 330
Query: 549 PQGSTFPPLLGPKSKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVL 608
+ + V F N+ +L+ + ++ DPDV+IG+ + + L
Sbjct: 331 STPFVRNVFCVDTCSQIVGTQVYEFQNQAEMLSSWSKFVRDVDPDVLIGYNICNFDIPYL 390
Query: 609 AHRAYELNIPQFSVFGR-------RLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLCDISN 661
RA L I F + GR + K S T I GRL D+
Sbjct: 391 LDRAKSLRIHNFPLLGRIHNFFSVAKETTFSSKAYGTRESKTTSI-----PGRLQLDMLQ 445
Query: 662 EMGQSLTPKCQNWELNEMYQVSCGIERKSLEINYLNPIYQED-ESQMLLALGENIENSII 720
M + K +++ LN + G +++ + + + + +S+ LA+ ++++ +
Sbjct: 446 VMQRDF--KLRSYSLNAVCSQFLGEQKEDVHYSIITDLQNGTADSRRRLAI-YCLKDAYL 502
Query: 721 TAEVAFRIQILSLTKQLTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQM 780
+ ++ ++ + G + L + + L + ++D +VP+
Sbjct: 503 PQRLMDKLMCFVNYTEMARVTGVPFNFLLARGQQIKVISQLFRKALQHDLVVPNI----- 557
Query: 781 KQDRQQKNEDPMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICF 840
+V+ +Y+G V EP KG + I +DF+SLYPSI+Q N+C+
Sbjct: 558 --------------RVNGTDEQYEGATVIEPIKGYYDTPIATLDFSSLYPSIMQAHNLCY 603
Query: 841 TTV-DRNPQDNEELPD------VPSREK------SRGVLPRLLANLVQRRREVKNLMKTE 887
TT+ D N + +L P+ + +G+LP +LA+L+ R++ K +K E
Sbjct: 604 TTLLDSNTAELLKLKQDVDYSVTPNGDYFVKPHVRKGLLPIILADLLNARKKAKADLKKE 663
Query: 888 NDASKKAQYDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAE- 946
D KKA D RQ ALK++ANS+YG G N R ++ VT+ GR+++ T+ + E
Sbjct: 664 TDPFKKAVLDGRQLALKVSANSVYGFTGATNGRLPCLAISSSVTSYGRQMIEKTKDVVEK 723
Query: 947 --------SLGLTVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERY-SLLEIDIDNI 997
S V+YGDTDSVM+ G +A+K+GE V++++ + ++++ + +
Sbjct: 724 RYRIENGYSHDAVVIYGDTDSVMVKFGVKTLPEAMKLGEEAANYVSDQFPNPIKLEFEKV 783
Query: 998 FXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDK 1057
+ F + + ++ KG++ RR+ CPL V L +L D+
Sbjct: 784 YFPYLLISKKRYAG---LFWTRTDTYDKMDSKGIETVRRDNCPLVSYVIDTALRKMLIDQ 840
Query: 1058 DSESALQEIYAYMEEIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRM-- 1115
D E A + +++ + N+I M + I LSK + M V++A RM
Sbjct: 841 DVEGA----QLFTKKVISDLLQNKIDMSQLVITKALSKTDYA----AKMAHVELAERMRK 892
Query: 1116 REAGRVVKAGSVITFVITKGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDPVYYLGK 1175
R+AG G + +VI KG R+ + + +N + D YYL
Sbjct: 893 RDAGSAPAIGDRVAYVIIKGAQGDQFY---------MRSEDPIYVLENNIPIDAKYYLEN 943
Query: 1176 QIFSPVQRLLERI 1188
Q+ P+ R+ E I
Sbjct: 944 QLSKPLLRIFEPI 956
>Hs4505933 [L] KOG0969 DNA polymerase delta catalytic subunit
Length = 1107
Score = 166 bits (419), Expect = 3e-40
Identities = 154/655 (23%), Positives = 286/655 (43%), Gaps = 77/655 (11%)
Query: 566 LSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNIPQFSVFGR 625
L V+ + E+ LL + +++ DPDVI G+ ++ L L RA L + F GR
Sbjct: 364 LGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGR 423
Query: 626 --------RLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLCDISNEMGQSLTPKCQNWELN 677
R + G+ + + + GR+ D+ + + K ++ LN
Sbjct: 424 VAGLCSNIRDSSFQSKQTGRRDTKVVSMV------GRVQMDMLQVLLREY--KLRSHTLN 475
Query: 678 EMYQVSCGIERKSLEINYLNPIYQ-EDESQMLLALGENIENSIITAEVAFRIQILSLTKQ 736
+ G +++ ++ + + + D+++ LA+ ++++ + + R+ +L +
Sbjct: 476 AVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRLAV-YCLKDAYLPLRLLERLMVLVNAVE 534
Query: 737 LTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEPQV 796
+ + G L + +R + K Q+ RQ +E + P V
Sbjct: 535 MARVTG----------------VPLSYLLSRGQQV---KVVSQLL--RQAMHEGLLMPVV 573
Query: 797 SSKKSK-YQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDRNPQ------D 849
S+ + Y G V EP KG + I +DF+SLYPSI+ N+C+TT+ R
Sbjct: 574 KSEGGEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLT 633
Query: 850 NEELPDVPSREK------SRGVLPRLLANLVQRRREVKNLMKTENDASKKAQYDIRQQAL 903
++ P+ ++ +G+LP++L NL+ R+ K + E D ++ D RQ AL
Sbjct: 634 EDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLAL 693
Query: 904 KLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAE---------SLGLTVVY 954
K++ANS+YG G + ++ VT GR+++ T+QL E S VVY
Sbjct: 694 KVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVY 753
Query: 955 GDTDSVMISTGCDNYMDAIKIGENFKKLVNERY-SLLEIDIDNIFXXXXXXXXXXXXXXN 1013
GDTDSVM G + +A+ +G V+ + S + ++ + ++
Sbjct: 754 GDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVY--FPYLLISKKRYAG 811
Query: 1014 VTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYAYMEEI 1073
+ F + + ++ KGL+ RR+ CPL + T L LL D+D E A+ A+ +++
Sbjct: 812 LLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAV----AHAQDV 867
Query: 1074 RQKVENNEIRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRMREAGRVVKAGSVITFVIT 1133
+ N I + + I L++ Y G + + +R R+ G G + +VI
Sbjct: 868 ISDLLCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVI- 926
Query: 1134 KGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLERI 1188
VA ++ + + ++ L D YYL +Q+ P+ R+ E I
Sbjct: 927 --------ISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPI 973
>At5g63960 [L] KOG0969 DNA polymerase delta catalytic subunit
Length = 1081
Score = 146 bits (369), Expect = 2e-34
Identities = 113/432 (26%), Positives = 197/432 (45%), Gaps = 40/432 (9%)
Query: 780 MKQDRQQKNEDPMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNIC 839
+++ +Q+ P Q S++ Y+G V E G ++ I +DF SLYPSI+ +N+C
Sbjct: 554 LRKGKQKNLVLPNAKQSGSEQGTYEGATVLEARTGFYEKPIATLDFASLYPSIMMAYNLC 613
Query: 840 FTTVDRNPQD-------NEELPDVPSREK------SRGVLPRLLANLVQRRREVKNLMKT 886
+ T+ P+D E + PS E +G+LP +L L+ R+ K +K
Sbjct: 614 YCTLV-TPEDVRKLNLPPEHVTKTPSGETFVKQTLQKGILPEILEELLTARKRAKADLKE 672
Query: 887 ENDASKKAQYDIRQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAE 946
D +KA D RQ ALK++ANS+YG G + ++ VT+ GR+++ T++L E
Sbjct: 673 AKDPLEKAVLDGRQLALKISANSVYGFTGATVGQLPCLEISSSVTSYGRQMIEQTKKLVE 732
Query: 947 SLGLT---------VVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERY-SLLEIDIDN 996
T V+YGDTDSVM+ G + A+ +G + ++ + ++++ +
Sbjct: 733 DKFTTLGGYQYNAEVIYGDTDSVMVQFGVSDVEAAMTLGREAAEHISGTFIKPIKLEFEK 792
Query: 997 IFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSD 1056
++ T +Q ++ ++ KG++ RR+ C L K + T LN +L D
Sbjct: 793 VYFPYLLINKKRYAGLLWTNPQQFDK---MDTKGIETVRRDNCLLVKNLVTESLNKILID 849
Query: 1057 KDSESALQEIYAYMEEIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRMR 1116
+D A + + + ++ N I + I L+K Y + +R R
Sbjct: 850 RDVPGAAENVKKTISDLLM----NRIDLSLLVITKGLTKTGDDYEVKSAHGELAERMRKR 905
Query: 1117 EAGRVVKAGSVITFVITKGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDPVYYLGKQ 1176
+A G + +VI K A ER+ + + +N + DP YYL Q
Sbjct: 906 DAATAPNVGDRVPYVIIK-------AAKGAKAYERSE--DPIYVLQNNIPIDPNYYLENQ 956
Query: 1177 IFSPVQRLLERI 1188
I P+ R+ E +
Sbjct: 957 ISKPLLRIFEPV 968
>7294203 [L] KOG0969 DNA polymerase delta catalytic subunit
Length = 1092
Score = 144 bits (363), Expect = 1e-33
Identities = 141/660 (21%), Positives = 277/660 (41%), Gaps = 85/660 (12%)
Query: 566 LSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNIPQFSVFGR 625
+ V + E +L+ + A ++ DPD++ G+ + L +RA L + F GR
Sbjct: 348 IGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGR 407
Query: 626 --------RLRKAWPDKFGKHNNSMTQFIVRDLFAGRLLCDISNEMGQSLTPKCQNWELN 677
+ + + G+ N F GR+ D+ + + K +++ LN
Sbjct: 408 IKNIRSVIKEQMLQSKQMGRRENQYVNF------EGRVPFDLLFVLLRDY--KLRSYTLN 459
Query: 678 EMYQVSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEVAFRIQILSLTKQL 737
+ +++ + + + + DE ++++ + + ++ + ++
Sbjct: 460 AVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEM 519
Query: 738 TNLAGNGWRQTLGGTRAGRNEYI--LLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEPQ 795
+ G L TR + + + LL + +I+P ++
Sbjct: 520 ARVTGVPLESLL--TRGQQIKVLSQLLRKAKTKGFIMPSYTSQ----------------- 560
Query: 796 VSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTV-----------D 844
+Y+G V EP++G + + I +DF SLYPSI+ N+C+TT+
Sbjct: 561 --GSDEQYEGATVIEPKRGYYADPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQ 618
Query: 845 RNPQDNEELPDVPSR------EKSRGVLPRLLANLVQRRREVKNLMKTENDASKKAQYDI 898
N QD +++ P+ E RG+LP +L +L+ R+ KN +K E D K+ D
Sbjct: 619 ENLQD-DQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKVETDPFKRKVLDG 677
Query: 899 RQQALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAES---------LG 949
RQ ALK++ANS+YG G + ++ VT GR ++ T+ ES
Sbjct: 678 RQLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENN 737
Query: 950 LTVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERY-SLLEIDIDNIFXXXXXXXXXX 1008
V+YGDTDSVM++ G ++++G +LV+ ++ ++++ + ++
Sbjct: 738 AVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKR 797
Query: 1009 XXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYA 1068
T + + ++ KG++ RR+ PL + L LL ++D + A+ A
Sbjct: 798 YAGLYFT---RPDTYDKMDCKGIETVRRDNSPLVANLMNSCLQKLLIERDPDGAV----A 850
Query: 1069 YMEEIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRMREAGRVVKAGSVI 1128
Y++++ + N I + I L+K Y + + ++ R+ G K G +
Sbjct: 851 YVKQVIADLLCNRIDISHLVITKELAK--TDYAAKQAHVELAAKMKKRDPGTAPKLGDRV 908
Query: 1129 TFVITKGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLERI 1188
+VI N +A + + +N + D YYL +Q+ P+ R+ E I
Sbjct: 909 PYVIC---------AAAKNTPAYQKAEDPLYVLENSVPIDATYYLEQQLSKPLLRIFEPI 959
>YDL102w [L] KOG0969 DNA polymerase delta catalytic subunit
Length = 1097
Score = 138 bits (348), Expect = 6e-32
Identities = 180/772 (23%), Positives = 320/772 (41%), Gaps = 110/772 (14%)
Query: 451 IMGPCWLKISDGDFDAVQG---ASHCAIEVQIDSPNHISATNE---KSSPSLNCISLSIQ 504
I+G W+ + G + ++ S C +EV I+ N I+ E + L +S I+
Sbjct: 264 IVGMSWITLPKGKYSMIEPNNRVSSCQLEVSINYRNLIAHPAEGDWSHTAPLRIMSFDIE 323
Query: 505 TV----MNAKENKQEIVAISMAVFKNLSQDSSIPQNLKP--NEIVTLVRPPQGSTFPPLL 558
+ + ++ I+ V SI KP + TL +T P+
Sbjct: 324 CAGRIGVFPEPEYDPVIQIANVV--------SIAGAKKPFIRNVFTL------NTCSPIT 369
Query: 559 GPKSKKELSGNVRLFNNEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNIP 618
G + E+ L N ++KV DPDVIIG+ + L +RA L +
Sbjct: 370 GSMIFSHAT-------EEEMLSNWRNFIIKV-DPDVIIGYNTTNFDIPYLLNRAKALKVN 421
Query: 619 QFSVFGRRLRKAWPDKFGKHNNSMTQFIVRDL----FAGRLLCDISNEMGQSLTPKCQNW 674
F FGR K + + S + R+ GRL D+ + + K +++
Sbjct: 422 DFPYFGRL--KTVKQEIKESVFSSKAYGTRETKNVNIDGRLQLDLLQFIQREY--KLRSY 477
Query: 675 ELNEMYQVSCGIERKSLEINYLNPIYQEDESQMLLALGENIENSIITAEVAFRIQILSLT 734
LN + G +++ + + ++ + D ++++ + + ++ L
Sbjct: 478 TLNAVSAHFLGEQKEDVHYSIISDLQNGDSETRRRLAVYCLKDAYLPLRLMEKLMALVNY 537
Query: 735 KQLTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEP 794
++ + G + L + + L + D ++P+ ++ Q ++D
Sbjct: 538 TEMARVTGVPFSYLLARGQQIKVVSQLFRKCLEIDTVIPNMQS--------QASDD---- 585
Query: 795 QVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTT------VDR-NP 847
+Y+G V EP +G + I +DFNSLYPSI+ N+C+TT V+R N
Sbjct: 586 -------QYEGATVIEPIRGYYDVPIATLDFNSLYPSIMMAHNLCYTTLCNKATVERLNL 638
Query: 848 QDNEELPDVPSRE------KSRGVLPRLLANLVQRRREVKNLMKTENDASKKAQYDIRQQ 901
+ +E+ P+ + + RG+LP +L L+ R+ K ++ E D K+ + RQ
Sbjct: 639 KIDEDYVITPNGDYFVTTKRRRGILPIILDELISARKRAKKDLRDEKDPFKRDVLNGRQL 698
Query: 902 ALKLTANSMYGCLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAESL---------GLTV 952
ALK++ANS+YG G + ++ VT GR +++ T+ + V
Sbjct: 699 ALKISANSVYGFTGATVGKLPCLAISSSVTAYGRTMILKTKTAVQEKYCIKNGYKHDAVV 758
Query: 953 VYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERYSLLEIDIDNIFXXXXXXXXXXXXXX 1012
VYGDTDSVM+ G + +A+ +G K V+ +L + I+ F
Sbjct: 759 VYGDTDSVMVKFGTTDLKEAMDLGTEAAKYVS---TLFKHPINLEFEKAYFPYLLINKKR 815
Query: 1013 NVTFDKQNNEK-TTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYAYME 1071
N +K L+ KGL RR+ C L V +VL +L +++ + AL A++
Sbjct: 816 YAGLFWTNPDKFDKLDQKGLASVRRDSCSLVSIVMNKVLKKILIERNVDGAL----AFVR 871
Query: 1072 EIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKN-MPAVQVALRM-REAGRVVKAGSVIT 1129
E + +N + + K I+ L+ P N P +A RM R G G +
Sbjct: 872 ETINDILHNRVDISKLIISKTLA------PNYTNPQPHAVLAERMKRREGVGPNVGDRVD 925
Query: 1130 FVITKGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDPVYYLGKQIFSPV 1181
+VI G N RA + + +N ++ D YYL Q+ +P+
Sbjct: 926 YVIIGG-----------NDKLYNRAEDPLFVLENNIQVDSRYYLTNQLQNPI 966
>7304154 [L] KOG0968 DNA polymerase zeta catalytic subunit
Length = 1869
Score = 110 bits (274), Expect = 2e-23
Identities = 108/442 (24%), Positives = 189/442 (42%), Gaps = 58/442 (13%)
Query: 787 KNEDPMEPQVSSK---KSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTT- 842
KN P+ P V ++ ++ L+ EP+ + + ++V+DF SLYPS+I +N CF+T
Sbjct: 1305 KNLVPLSPSVQARAHMRAPEYLALIMEPQSRFYADPLIVLDFQSLYPSMIIAYNYCFSTC 1364
Query: 843 ---------------------VDRNPQDNEELPDVPS----------REKSRGVLPRLLA 871
V R D+ + RE G+LPR+L
Sbjct: 1365 LGRVEHLGGSSPFEFGASQLRVSRQMLQKLLEHDLVTVSPCGVVFVKREVREGILPRMLT 1424
Query: 872 NLVQRRREVKNLMKTENDASKKAQY-DIRQQALKLTANSMYG-CLGYVNSRFYAKPLAML 929
++ R+ VK MK D+S + RQ LKL AN YG + R + +
Sbjct: 1425 EILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMANVTYGYTAANFSGRMPSVEVGDS 1484
Query: 930 VTNKGREILMNTRQLAES---LGLTVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNE- 985
V +KGRE L +L E+ + VVYGDTDS+ + N +A +IGE K V E
Sbjct: 1485 VVSKGRETLERAIKLVENNEEWKVRVVYGDTDSMFVLVPGRNRAEAFRIGEEIAKAVTEM 1544
Query: 986 RYSLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEV 1045
+++ ++ ++ ++ + E+ E KG++ RR+ CP ++
Sbjct: 1545 NPQPVKLKLEKVY--QPCMLQTKKRYVGYMYETADQEQPVYEAKGIETVRRDGCPAVAKM 1602
Query: 1046 STRVLNILLSDKDSESALQEIYAYMEEIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKN 1105
+VL IL +D + +I AY+ K+ + + I + + Y
Sbjct: 1603 LEKVLRILFETQD----VSKIKAYVCRQFTKLLSGRANLQDL-IFAKEFRGLNGYKPTAC 1657
Query: 1106 MPAVQVALR--MREAGRVVKAGSVITFVITKGXXXXXXXXXXANVAERARALNEVMNKKN 1163
+PA+++ + ++ V + G + F+I G + R+ ++++
Sbjct: 1658 VPALELTRKWMQKDPRHVPRRGERVPFIIVNG-------PPGMQLIRLVRSPHDIL-ANE 1709
Query: 1164 GLKPDPVYYLGKQIFSPVQRLL 1185
G K + +YY+ K I P+ R L
Sbjct: 1710 GHKINAIYYITKAIIPPLNRCL 1731
>Hs4506483 [L] KOG0968 DNA polymerase zeta catalytic subunit
Length = 3052
Score = 103 bits (257), Expect = 2e-21
Identities = 164/782 (20%), Positives = 302/782 (37%), Gaps = 125/782 (15%)
Query: 488 TNEKSSPSLNC---ISLSIQTVMNAK--ENKQEIVAISM--------------------A 522
T++ PSLN +SIQ + AK Q + IS+ A
Sbjct: 2186 TSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICA 2245
Query: 523 VFKNLSQDSSIPQNLKPNEIVTLVRPPQGSTFP-------PLLGPKSKKELSG-NVRLFN 574
+F +S D+ +P K +V + F PLL + ++G V
Sbjct: 2246 LFYCISSDTPLPDTEKTELTGVIVIDKDKTVFSQDIRYQTPLL---IRSGITGLEVTYAA 2302
Query: 575 NEKTLLNCFCALLKVNDPDVIIGHRLEGVILDVLAHRAYELNIPQFSVFGRRLRKAWPDK 634
+EK L + ++K DPD+++G+ ++ L RA L+I + R ++
Sbjct: 2303 DEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENR 2362
Query: 635 FGKHNNSMTQFIVRDL-FAGRLLCDISNEMGQSLTPKCQNWELNEMYQVSCGIERKSLEI 693
F + + + ++ GR+ ++ M + +E VS + + +
Sbjct: 2363 FAAERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFE-----NVSFHVLHQRFPL 2417
Query: 694 NYLNPIYQEDESQMLLALGENIENSIITA----EVAFRIQILSLTKQLTNLAGNGWRQTL 749
+ +++ L + +++ + ++ ++ ++ T ++ L G + L
Sbjct: 2418 FTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVL 2477
Query: 750 GGTRAGRNEYILLHEFNRNDYIVPDKETRQMKQDRQQKNEDPMEPQVSSKKSKYQGGLVF 809
R E ++L +YI +Q Q R PQ L+
Sbjct: 2478 TRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRA--------PQCVP--------LIM 2521
Query: 810 EPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTVDRNPQDNEEL-------------PDV 856
EPE + N +LV+DF SLYPSI+ +N CF+T + ++ + PD+
Sbjct: 2522 EPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDL 2581
Query: 857 -------------------PSREKSRGVLPRLLANLVQRRREVKNLMKT-ENDASKKAQY 896
PS K GVLPR+L +++ R VK MK + D +
Sbjct: 2582 LYQVRHDITVSPNGVAFVKPSVRK--GVLPRMLEEILKTRFMVKQSMKAYKQDRALSRML 2639
Query: 897 DIRQQALKLTANSMYGCLGYVNSRFYAK----PLAMLVTNKGREILMNTRQLAESL---G 949
D RQ LKL AN +G Y ++ F + + + +K RE L +L G
Sbjct: 2640 DARQLGLKLIANVTFG---YTSANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWG 2696
Query: 950 LTVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERYSL-LEIDIDNIFXXXXXXXXXX 1008
VVYGDTDS+ + + KIG+ + V +++ + ++
Sbjct: 2697 ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKR 2756
Query: 1009 XXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDKDSESALQEIYA 1068
++ + + + KG++ RR+ CP ++ R L +L +D + I
Sbjct: 2757 YV--GYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRD----ISLIKQ 2810
Query: 1069 YMEEIRQKVENNEIRMDKYKINTRLSKDPKSYPGGKNMPAVQVALRMREAGR--VVKAGS 1126
Y++ K+ + + + I + + SY G +PA+++ +M R + G
Sbjct: 2811 YVQRQCMKLLEGKASIQDF-IFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGE 2869
Query: 1127 VITFVITKGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDPVYYLGKQIFSPVQRLLE 1186
+ +VI G + + R EV+ L+ + YY+ KQI P+ R+
Sbjct: 2870 RVPYVIIYG-------TPGVPLIQLVRRPVEVLQDPT-LRLNATYYITKQILPPLARIFS 2921
Query: 1187 RI 1188
I
Sbjct: 2922 LI 2923
>SPAC688.10 [L] KOG0968 DNA polymerase zeta catalytic subunit
Length = 1480
Score = 99.0 bits (245), Expect = 5e-20
Identities = 93/374 (24%), Positives = 157/374 (41%), Gaps = 54/374 (14%)
Query: 791 PMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTT-------- 842
P QV+ + + LV EP+ L+ N ++V+DF SLYPSII +N+C++T
Sbjct: 922 PSAKQVAEQNALEALPLVMEPKSDLYNNPVVVLDFQSLYPSIIIAYNLCYSTCLGPVKIV 981
Query: 843 ---VDRNPQDNEELPDVPSREKS-----------------RGVLPRLLANLVQRRREVKN 882
V + P++ + K+ + +L ++L L++ R VK
Sbjct: 982 NGKVKLGFMFHSSNPNIVNLIKNDVYISPNGYAYVKENVRKSLLAKMLEELIETRNMVKR 1041
Query: 883 LMKTENDASKKAQYDIRQQALKLTANSMYG-CLGYVNSRFYAKPLAMLVTNKGREILMNT 941
MK + + RQ ALKL AN YG + R +A + GREIL +
Sbjct: 1042 GMKDCDSDYVNKVLNSRQLALKLIANVTYGYTSASFSGRMPCSEIADTIVETGREILSYS 1101
Query: 942 RQLAESLGL---TVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERY-SLLEIDIDNI 997
+ +L VVYGDTDS+ + A IG+ + R+ S + + + I
Sbjct: 1102 LEYINTLDFCHAKVVYGDTDSLFVELPGATKEQAFDIGQQLANNITSRFPSPIRLKFEKI 1161
Query: 998 FXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLSDK 1057
+ F+ + + E KG++ RR+ P+ +++ R L IL K
Sbjct: 1162 Y--FPCFLLAKKRYVGFKFESVSQKAPIFEAKGIETVRRDGTPVQQQLLRRCLEILFKTK 1219
Query: 1058 DSESALQEI----YAYME---EIRQKVENNEIRMDKYK-----------INTRLSKDPKS 1099
D + +E Y M + + E+R++KYK ++KDP+
Sbjct: 1220 DLSTVKKEFQNVCYQIMSGNVPVMDFCFSKEVRLEKYKELSTAPPGAVMARRLMTKDPRR 1279
Query: 1100 YPG-GKNMPAVQVA 1112
P G+ +P + +A
Sbjct: 1280 EPQYGERVPYLIIA 1293
>At1g67500 [L] KOG0968 DNA polymerase zeta catalytic subunit
Length = 1894
Score = 94.4 bits (233), Expect = 1e-18
Identities = 97/435 (22%), Positives = 173/435 (39%), Gaps = 60/435 (13%)
Query: 715 IENSIITAEVAFRIQILSLTKQLTNLAGNGWRQTLGGTRAGRNEYILLHEFNRNDYIVPD 774
I + + E+ ++ +++ T +L + G + L R E +LL + +Y+
Sbjct: 1270 IRRANLNLEIMSQLDMINRTSELARVFGIDFFSVLSRGSQYRVESMLLRLAHTQNYLAIS 1329
Query: 775 KETRQMKQDRQQKNEDPMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQ 834
P QV+S+ + LV EPE + + ++V+DF SLYPS+I
Sbjct: 1330 ----------------PGNQQVASQPAMECVPLVMEPESAFYDDPVIVLDFQSLYPSMII 1373
Query: 835 EFNICFTT-------------------VDRNP-QDNEELPDVPSR------EKSRGVLPR 868
+N+CF+T +D + QD ++ P+ E RG+LPR
Sbjct: 1374 AYNLCFSTCLGKLAHLKMNTLGVSSYSLDLDVLQDLNQILQTPNSVMYVPPEVRRGILPR 1433
Query: 869 LLANLVQRRREVKNLMK--TENDASKKAQYDIRQQALKLTANSMYG--CLGYVNSRFYAK 924
LL ++ R VK MK T ++A ++ RQ ALKL AN YG G+ + R
Sbjct: 1434 LLEEILSTRIMVKKAMKKLTPSEAVLHRIFNARQLALKLIANVTYGYTAAGF-SGRMPCA 1492
Query: 925 PLAMLVTNKGREILMNTRQLA---ESLGLTVVYGDTDSVMISTGCDNYMDAIKIGENFKK 981
LA + GR L ++ VVYGDTDS+ + +A +G+
Sbjct: 1493 ELADSIVQCGRSTLEKAISFVNANDNWNARVVYGDTDSMFVLLKGRTVKEAFVVGQEIAS 1552
Query: 982 LVNE-RYSLLEIDIDNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCP 1040
+ E + + ++ ++ +++ N + + KG++ RR+ C
Sbjct: 1553 AITEMNPHPVTLKMEKVY--HPCFLLTKKRYVGYSYESPNQREPIFDAKGIETVRRDTCE 1610
Query: 1041 LSKEVSTRVLNILLSDKDSESALQEIYAYMEEI-------RQKVENNEIRMDKYKINTRL 1093
+ + L + K+ +Y + I + + E+R+ Y
Sbjct: 1611 AVAKTMEQSLRLFFEQKNISKVKSYLYRQWKRILSGRVSLQDFIFAKEVRLGTYSTRDSS 1670
Query: 1094 SKDPKSYPGGKNMPA 1108
P + K+M A
Sbjct: 1671 LLPPAAIVATKSMKA 1685
>CE27403 [L] KOG0968 DNA polymerase zeta catalytic subunit
Length = 1154
Score = 90.9 bits (224), Expect = 1e-17
Identities = 74/293 (25%), Positives = 128/293 (43%), Gaps = 47/293 (16%)
Query: 807 LVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTV-------------DRN------- 846
L+ EP+ ++ + ++V+DF SLYPS++ +N C++T+ RN
Sbjct: 642 LILEPQSKVYFDPVIVLDFQSLYPSMVIAYNYCYSTILGKIGNLVQMNDESRNREEIVLG 701
Query: 847 -----PQDNEELPDVPSRE--------------KSRGVLPRLLANLVQRRREVKNLMKTE 887
P ++ + V +E K GV+P LL ++ R VK+ MK
Sbjct: 702 AIKYHPSKDDIVKLVAYKEVCASPLASMFVKKSKREGVMPLLLREILAARIMVKSAMKRT 761
Query: 888 NDASKKAQYDIRQQALKLTANSMYG-CLGYVNSRFYAKPLAMLVTNKGREILMNTRQLAE 946
+ K D RQ ALKL AN YG + R LA + KGRE L + ++ +
Sbjct: 762 KNKKLKRILDARQLALKLVANVSYGYTAANWSGRMPCAELADAILGKGRETLERSIEMVQ 821
Query: 947 S---LGLTVVYGDTDSVMISTGCDNYMDAIKIGENF-KKLVNERYSLLEIDIDNIFXXXX 1002
G V+YGDTDS+ + + +A +IG + N + + ++ ++
Sbjct: 822 RGDYGGAEVIYGDTDSMFVLVRGASVEEAFEIGRRIVDDVTNSNPDPVVLKLEKVYKGCV 881
Query: 1003 XXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILLS 1055
+ N++ +L+ KG++ RR+ CP+ EV + L ++ S
Sbjct: 882 LETKKRYAG---WMYEHENDEGSLDAKGIETVRRDTCPIVAEVLEKSLGLIFS 931
>YPL167c [L] KOG0968 DNA polymerase zeta catalytic subunit
Length = 1504
Score = 86.7 bits (213), Expect = 2e-16
Identities = 100/439 (22%), Positives = 181/439 (40%), Gaps = 59/439 (13%)
Query: 791 PMEPQVSSKKSKYQGGLVFEPEKGLHKNYILVMDFNSLYPSIIQEFNICFTTV-----DR 845
P + V +K+ LV EPE +K+ ++V+DF SLYPSI+ +N C++T+ +
Sbjct: 942 PGKKDVRKQKALECVPLVMEPESAFYKSPLIVLDFQSLYPSIMIGYNYCYSTMIGRVREI 1001
Query: 846 NPQDNE------ELP---------DVPSREKS---------RGVLPRLLANLVQRRREVK 881
N +N LP DV + L ++L +++ R +K
Sbjct: 1002 NLTENNLGVSKFSLPRNILALLKNDVTIAPNGVVYAKTSVRKSTLSKMLTDILDVRVMIK 1061
Query: 882 NLMKT--ENDASKKAQYDIRQQALKLTANSMYGCLGY-VNSRFYAKPLAMLVTNKGREIL 938
M +++ + K + +Q ALKL AN YG + R LA + GRE L
Sbjct: 1062 KTMNEIGDDNTTLKRLLNNKQLALKLLANVTYGYTSASFSGRMPCSDLADSIVQTGRETL 1121
Query: 939 MNTRQLAE---SLGLTVVYGDTDSVMISTGCDNYMDAIKIGENFKKLVNERY-SLLEIDI 994
+ E + VVYGDTDS+ + ++A IG + V + + +
Sbjct: 1122 EKAIDIIEKDETWNAKVVYGDTDSLFVYLPGKTAIEAFSIGHAMAERVTQNNPKPIFLKF 1181
Query: 995 DNIFXXXXXXXXXXXXXXNVTFDKQNNEKTTLEVKGLDMKRREFCPLSKEVSTRVLNILL 1054
+ ++ +++ + + KG++ RR+ P +++ + + +L
Sbjct: 1182 EKVY--HPSILISKKRYVGFSYESPSQTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLF 1239
Query: 1055 SDKDSESALQEIYAYMEEIRQKVENNEIRMDKY----KINTRLSKDPKSYPGGKNMPAVQ 1110
KD L +I Y++ K++ ++ + ++ K K+ P G AV
Sbjct: 1240 QTKD----LSKIKKYLQNEFFKIQIGKVSAQDFCFAKEVKLGAYKSEKTAPAG----AVV 1291
Query: 1111 VALRMREAGRV-VKAGSVITFVITKGXXXXXXXXXXANVAERARALNEVMNKKNGLKPDP 1169
V R+ E R + I +++ KG + ER + E + +N L+ D
Sbjct: 1292 VKRRINEDHRAEPQYKERIPYLVVKGKQGQL-------LRERCVSPEEFLEGEN-LELDS 1343
Query: 1170 VYYLGKQIFSPVQRLLERI 1188
YY+ K + P+ RL I
Sbjct: 1344 EYYINKILIPPLDRLFNLI 1362
>CE24463 [B] KOG1911 Heterochromatin-associated protein HP1 and related
CHROMO domain proteins
Length = 679
Score = 52.8 bits (125), Expect = 4e-06
Identities = 48/205 (23%), Positives = 92/205 (44%), Gaps = 12/205 (5%)
Query: 14 QKARNNKSNRDVLDEQLEEENVYDLIDEDQYRSKKRQELLR--------DDFVEDDDGSG 65
+K + NK+ R D+ ++++ + + +SKK ++ + +D DD+
Sbjct: 232 KKWKKNKAKRSKRDDSSDDDSEMERRRKKSKKSKKSKKFKKSEKRKRAVNDSSSDDEDEE 291
Query: 66 YVDRGVDEWDQSQEFYSDEDDGVDAKSGKKRNKTSKNNKGKDTISDIIKQQ--NVKRKMT 123
+ + S +D + KS KKR+K SK ++ + +++ VK+
Sbjct: 292 EKPEKRSKKSKKAVIDSSSEDEEEEKSSKKRSKKSKKESDEEQQASDSEEEVVEVKKNSK 351
Query: 124 MPTEKPKKVSLAEFDDILSEFDAEPLVKKPKLTISRKQPANTTPMNYKHPQVDTSPLKGK 183
P + PKK ++ E + S + E +VKK K + K+ A + + + +V+ SP K K
Sbjct: 352 SPKKTPKKTAVKEESEESSGDEEEEVVKKKKSSKINKRKAKESSSD-EEEEVEESP-KKK 409
Query: 184 DVVPFKADSVNPIDCDSMEEDHDIE 208
P K+ + +S EE D E
Sbjct: 410 TKSPRKSSKKSAAKEESEEESSDNE 434
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.133 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,981,629
Number of Sequences: 60738
Number of extensions: 3787281
Number of successful extensions: 13981
Number of sequences better than 1.0e-05: 21
Number of HSP's better than 0.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 13807
Number of HSP's gapped (non-prelim): 53
length of query: 1430
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1311
effective length of database: 23,161,394
effective search space: 30364587534
effective search space used: 30364587534
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)