ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3343 suspect: Pn PT KOG3609 Inorganic ion transport and metabolism Receptor-activated Ca2+-permeable cation channels (STRPC family) r_klactIII3343 suspect: Pn PT KOG3609 Signal transduction mechanisms Receptor-activated Ca2+-permeable cation channels (STRPC family)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= r_klactIII3343 1177574 1175547 -676 
         (676 letters)

Database: KOG eukaryal database 04/03 
           60,738 sequences; 30,389,216 total letters

Searching..................................................done

Color Key for Alignment Scores:   


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

7301861 [PT] KOG3609 Receptor-activated Ca2+-permeable cation ch...    55   4e-07
Hs9966865 [PT] KOG3609 Receptor-activated Ca2+-permeable cation ...    52   2e-06
Hs4507687 [PT] KOG3609 Receptor-activated Ca2+-permeable cation ...    52   3e-06
Hs7706747 [PT] KOG3609 Receptor-activated Ca2+-permeable cation ...    50   9e-06
7290757 [PT] KOG3676 Ca2+-permeable cation channel OSM-9 and rel...    50   9e-06

>7301861 [PT] KOG3609 Receptor-activated Ca2+-permeable cation channels
           (STRPC family)
          Length = 1275

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 64/227 (28%), Positives = 94/227 (41%), Gaps = 45/227 (19%)

Query: 325 PSEHWDIVSYRIL---ACAAPLVWSRLLLY--LESERFVGALLVVLAHMMRESIYFFSLL 379
           P EHW      +L   A AA +V+S L L         +G L V L  M+ + I FF + 
Sbjct: 494 PREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIY 553

Query: 380 ILIMIGFLQGFLGL--------------------DSADGRREIT-WPILSNLFTT----- 413
            L++  F  G   L                    D  D  +  T W   SNLF T     
Sbjct: 554 TLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLF 613

Query: 414 -----ILGDGGFDM--FERFAPPYAAILYYSYCFIVTIILLNILIALYSSAYQKVIDNVT 466
                ++    FD+   + F   +A +++ SY  I  I+LLN+LIA+ S++YQ + +   
Sbjct: 614 WASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERAD 673

Query: 467 DEYLALMAQKTLRYIRAPDEDVYVPPLNLIEICITPIIWMLPKTQGK 513
            E+    +Q  + Y    D     PP NL      P + ML KT G+
Sbjct: 674 TEWKFARSQLWMSYFE--DGGTIPPPFNL-----CPNMKMLRKTLGR 713


>Hs9966865 [PT] KOG3609 Receptor-activated Ca2+-permeable cation channels
           (STRPC family)
          Length = 862

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 45/183 (24%), Positives = 84/183 (45%), Gaps = 25/183 (13%)

Query: 331 IVSYRILACAAPLVWSRLLLYLESERFVGALLVVLAHMMRESIYFFSLLILIMIGFLQGF 390
           I+S  + A A  L +SR+   L +    G L + L   +++   F  + I++ + F+ G 
Sbjct: 538 IISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGM 597

Query: 391 LGLDS--------------ADGRREITWPI--LSNLFTTILGDGGFDMFERFAPPYAAIL 434
             L S               +  + + W I  LS + + +L    +D   +F      +L
Sbjct: 598 FNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLK---YD--HKFIENIGYVL 652

Query: 435 YYSYCFIVTIILLNILIALYSSAYQKVIDNVTDEYLALMAQKTLRYIRAPDEDVYVP-PL 493
           Y  Y   + ++LLN+LIA+ +++YQ++ ++   E+    A+  L Y    DE   +P P 
Sbjct: 653 YGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYF---DEGRTLPAPF 709

Query: 494 NLI 496
           NL+
Sbjct: 710 NLV 712


>Hs4507687 [PT] KOG3609 Receptor-activated Ca2+-permeable cation channels
           (STRPC family)
          Length = 848

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 48/189 (25%), Positives = 85/189 (44%), Gaps = 24/189 (12%)

Query: 324 LPSEHWDIVSYRILACAAPLVWSRLLLYLESERFVGALLVVLAHMMRESIYFFSLLILIM 383
           LPS+   I+S  + A A  L +SR+   L +    G L + L   +++   F  L I++ 
Sbjct: 530 LPSDP-QIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVF 588

Query: 384 IGFLQGFLGLDS--------------ADGRREITWPI--LSNLFTTILGDGGFDMFERFA 427
             F+ G   L S               +  + + W I  LS + + +L    +D   +F 
Sbjct: 589 FAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLK---YD--HKFI 643

Query: 428 PPYAAILYYSYCFIVTIILLNILIALYSSAYQKVIDNVTDEYLALMAQKTLRYIRAPDED 487
                +LY  Y   + ++LLN+LIA+ +S+YQ++ D+   E+    ++  L Y    D  
Sbjct: 644 ENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYF--DDGK 701

Query: 488 VYVPPLNLI 496
              PP +L+
Sbjct: 702 TLPPPFSLV 710


>Hs7706747 [PT] KOG3609 Receptor-activated Ca2+-permeable cation channels
           (STRPC family)
          Length = 977

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 72/337 (21%), Positives = 124/337 (36%), Gaps = 35/337 (10%)

Query: 168 ELAMDMHCTIVIGSSGYQRCLKWLWRGWIVQNKLNPETYILSPVVPSCEVSKHFTPERL- 226
           E     +C  ++ S  Y     W  R W V+        +L PV   C +    +P  L 
Sbjct: 299 EFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKSPLGLF 358

Query: 227 -RAPIYQNLLQIIFSLLYLVLFTVVVNQKDSVNVQ----PIGFWESLFYVFTLGHALDEL 281
            R P  + +      L +L L  +     D  ++     P    E +   + LG    E+
Sbjct: 359 IRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEI 418

Query: 282 VKCYHVGWA-YI-GFWNVYHDFMFXXXXXXXXXXXXXXXPWKADLPSEHWD-----IVSY 334
            + +  G   YI  +WN+    M                 + A  P E WD     +V+ 
Sbjct: 419 KQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSALNPRESWDMWHPTLVAE 478

Query: 335 RILACAAPLVWSRLLLYLESERFVGALLVVLAHMMRESIYFFSLLILIMIGFLQGF---- 390
            + A A      RL+    +   +G L + L  M+ + + F  +  L+++ F  G     
Sbjct: 479 ALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLY 538

Query: 391 ------LGLDSADGRREITWPILSNLFTTILG-----DGGFDMF-------ERFAPPYAA 432
                  GL     R E      S LF T+        G  +++         F     A
Sbjct: 539 FYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGA 598

Query: 433 ILYYSYCFIVTIILLNILIALYSSAYQKVIDNVTDEY 469
            ++ +Y  I  ++LLN+LIA+ +++YQ + D+   E+
Sbjct: 599 TMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635


>7290757 [PT] KOG3676 Ca2+-permeable cation channel OSM-9 and related
           channels (OTRPC family)
          Length = 1123

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 40/155 (25%), Positives = 71/155 (45%), Gaps = 7/155 (4%)

Query: 336 ILACAAPLVWSRLLLYLESERFVGALLVVLAHMMRESIYFFSLLILIMI-GFLQGFLGLD 394
           IL  A P  W  L+ +  + R  G  + ++  M+   ++ F ++  I++ GF Q F  L 
Sbjct: 528 ILIFAVPGSWFLLMFFAGAIRLTGPFVTMIYSMITGDMFTFGIIYCIVLCGFSQAFYFLY 587

Query: 395 SADGRREITW-----PILSNLFTTILGDGGF-DMFERFAPPYAAILYYSYCFIVTIILLN 448
               + + T           LF T LGD  + D+ +   P  +  ++  +   V I+LLN
Sbjct: 588 KGHPQVQSTMFNTYTSTWMALFQTTLGDYNYPDLNQTTYPNLSKTVFVIFMIFVPILLLN 647

Query: 449 ILIALYSSAYQKVIDNVTDEYLALMAQKTLRYIRA 483
           +LIA+  + Y  VI+    E++   A+  +   RA
Sbjct: 648 MLIAMMGNTYVTVIEQSEKEWMKQWAKIVVTLERA 682


  Database: KOG eukaryal database 04/03
    Posted date:  Apr 14, 2003  1:07 PM
  Number of letters in database: 30,389,216
  Number of sequences in database:  60,738
  
Lambda     K      H
   0.323    0.139    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,642,489
Number of Sequences: 60738
Number of extensions: 1601388
Number of successful extensions: 4080
Number of sequences better than 1.0e-05: 5
Number of HSP's better than  0.0 without gapping: 0
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4078
Number of HSP's gapped (non-prelim): 5
length of query: 676
length of database: 30,389,216
effective HSP length: 113
effective length of query: 563
effective length of database: 23,525,822
effective search space: 13245037786
effective search space used: 13245037786
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)