ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3377 good B KOG0355 Chromatin structure and dynamics DNA topoisomerase type II
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3377 1184534 1188838 1435
(1435 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL088w [B] KOG0355 DNA topoisomerase type II 1835 0.0
SPBC1A4.03c [B] KOG0355 DNA topoisomerase type II 1212 0.0
ECU04g0350 [B] KOG0355 DNA topoisomerase type II 1097 0.0
At3g23890 [B] KOG0355 DNA topoisomerase type II 1061 0.0
Hs19913408 [B] KOG0355 DNA topoisomerase type II 1041 0.0
Hs19913406 [B] KOG0355 DNA topoisomerase type II 1034 0.0
CE06184 [B] KOG0355 DNA topoisomerase type II 1018 0.0
7298585 [B] KOG0355 DNA topoisomerase type II 1014 0.0
CE25068 [B] KOG0355 DNA topoisomerase type II 715 0.0
CE07645 [B] KOG0355 DNA topoisomerase type II 541 e-153
CE17740 [B] KOG0355 DNA topoisomerase type II 512 e-144
CE24315 [B] KOG0355 DNA topoisomerase type II 256 2e-67
CE18656 [B] KOG0355 DNA topoisomerase type II 206 3e-52
CE01933 [B] KOG0355 DNA topoisomerase type II 132 5e-30
At3g10270 [B] KOG0355 DNA topoisomerase type II 105 4e-22
At5g04130 [B] KOG0355 DNA topoisomerase type II 100 2e-20
At3g10690 [B] KOG0355 DNA topoisomerase type II 79 4e-14
At2g13720 [B] KOG0355 DNA topoisomerase type II 55 8e-07
>YNL088w [B] KOG0355 DNA topoisomerase type II
Length = 1428
Score = 1835 bits (4752), Expect = 0.0
Identities = 915/1308 (69%), Positives = 1049/1308 (79%), Gaps = 33/1308 (2%)
Query: 2 TQSKTVSERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFK 61
T+ + S++YQKISQLEHILKRPDTYIGSVE QE QWI+DE TDCMIEK V IVPGLFK
Sbjct: 3 TEPVSASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTIVPGLFK 62
Query: 62 IFDEILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFG 121
IFDEILVNAADNKVRDPSMK+IDV I+ EE+TIEVKNDGKGIP+EIH+KE IYIPE+IFG
Sbjct: 63 IFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPIEIHNKENIYIPEMIFG 122
Query: 122 HLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHP 181
HLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETAD + G KY+Q WENNMS CHP
Sbjct: 123 HLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADLNVGQKYVQKWENNMSICHP 182
Query: 182 PKITSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKAL 241
PKITSYKKGPSYTKV FKPDL RFGM +LD+DI+GVMRRRVYDINGSVRD+NV LNGK+L
Sbjct: 183 PKITSYKKGPSYTKVTFKPDLTRFGMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSL 242
Query: 242 KIRNFKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVSE 301
KIRNFKNYVELYLKSLEK + E + IPTILYERIN+RWEVAFAVS+
Sbjct: 243 KIRNFKNYVELYLKSLEK------KRQLDNGEDGAAKSDIPTILYERINNRWEVAFAVSD 296
Query: 302 NSFQQISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKK-TIKPFQIKNNMFIFINCL 360
SFQQISFVNSIATT GGTHVNY+TDQI+KK+S+ LKK+KK ++K FQIKNNMFIFINCL
Sbjct: 297 ISFQQISFVNSIATTMGGTHVNYITDQIVKKISEILKKKKKKSVKSFQIKNNMFIFINCL 356
Query: 361 IENPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQLKKTD 420
IENPAFTSQTKEQLTTRVKDFGS+CE+P E+INKIMKTDLAT++FEIAD N LKK+D
Sbjct: 357 IENPAFTSQTKEQLTTRVKDFGSRCEIPLEYINKIMKTDLATRMFEIADANEENALKKSD 416
Query: 421 GSRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRG 480
G+RK+RIT YPKLEDAN AGTKEGYKCTLVLTEGD RDYYGC+PLRG
Sbjct: 417 GTRKSRITNYPKLEDANKAGTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRG 476
Query: 481 KMLNVREATPDQISKNAEIQAIKKIMGLQHKKRYEDTTTLRYGHIMIMTDQDHDGSHIKG 540
KMLNVREA+ DQI KNAEIQAIKKIMGLQH+K+YEDT +LRYGH+MIMTDQDHDGSHIKG
Sbjct: 477 KMLNVREASADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKG 536
Query: 541 LIINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWREEESHKYT 600
LIINFLESSFPGLLDI GFL ++P K TI+FYNMPDYEKWREEESHK+T
Sbjct: 537 LIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYEKWREEESHKFT 596
Query: 601 WKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWLKL 660
WKQKYYKGLGTS QE REYFS LD+HLK FH+LQG+D IDLAFSKKKADDRKEWL+
Sbjct: 597 WKQKYYKGLGTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQ 656
Query: 661 YEPGTVLDPKLTEIPISDFINKELILFSLADNIRSIPSVLDGLKPGQRKVIYACFKRNLK 720
YEPGTVLDP L EIPISDFINKELILFSLADNIRSIP+VLDG KPGQRKV+Y CFK+NLK
Sbjct: 657 YEPGTVLDPTLKEIPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLK 716
Query: 721 SEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLKPNGAFGTRATGGKD 780
SE+KVAQL YVSE T YHHGEQSL QTI+GLAQ+FVGSNNIYLL PNGAFGTRATGGKD
Sbjct: 717 SELKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKD 776
Query: 781 SAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVIPMVLVNGTEGIGTG 840
+AA RYI+TELNKLTRKIF+ DDPL YIQ+DE+TVEPEWYLP++PM+LVNG EGIGTG
Sbjct: 777 AAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTG 836
Query: 841 WSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQKYRTYGRIEQIDEN 900
WST IPPFNP++I+ N++ LM EE+EQM PW+RGW G++E+I+P +YR YGRIEQI +N
Sbjct: 837 WSTYIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQIGDN 896
Query: 901 TLEITELPPKTWTSVIKEHLLLGLSGNDKVKPWIKDIQEQHGATIKFIITLTSDEMEKTR 960
LEITELP +TWTS IKE+LLLGLSGNDK+KPWIKD++EQH IKFIITL+ +EM KTR
Sbjct: 897 VLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDNIKFIITLSPEEMAKTR 956
Query: 961 KIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYYTRLTYYQKRKDYIGERL 1020
KIGFYERFKL+S +SL NMVAFDP GKIKKY+ V +ILS+FYY RL YYQKRKD++ ERL
Sbjct: 957 KIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERL 1016
Query: 1021 KWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGFPRINKEGKPTYGKVEEQAQ 1080
+WEVEK S+QVKFI MI+EK+L+V+NKPR + +EL +LGFPR NKEGKP YG ++
Sbjct: 1017 QWEVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYYGSPNDE-- 1074
Query: 1081 IXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKFGNYDYLLGMKIWALTKERYEKLM 1140
V+NGPEE +G Y+YLLGM+IW+LTKERY+KL+
Sbjct: 1075 -IAEQINDVKGATSDEEDEESSHEDTENVINGPEELYGTYEYLLGMRIWSLTKERYQKLL 1133
Query: 1141 KQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKFIQYDEEVRNSIVPD--AATTXXXX 1198
KQ QEK+TELE LLKLSAKD+W DL F Y++F+Q D E R VP+ + T
Sbjct: 1134 KQKQEKETELENLLKLSAKDIWNTDLKAFEVGYQEFLQRDAEARGGNVPNKGSKTKGKGK 1193
Query: 1199 XXXXXXXXXXXSKQPKK---RARKSVKREYVDFERVLIEPRVIEKVKRVPKIKTENNDIV 1255
SK+ KK R K +K E +FER+L+E +++ K K KIK E
Sbjct: 1194 RKLVDDEDYDPSKKNKKSTARKGKKIKLEDKNFERILLEQKLVTKSKAPTKIKKE----- 1248
Query: 1256 KKLSKAKSTKQTTPEVKEDPEPTASHASTIFAKKADSVSKEPEEDNDE 1303
K S +T E +E+ P+++ +S+IF K +ED DE
Sbjct: 1249 ----KTPSVSETKTE-EEENAPSSTSSSSIFDIK--------KEDKDE 1283
>SPBC1A4.03c [B] KOG0355 DNA topoisomerase type II
Length = 1485
Score = 1212 bits (3137), Expect = 0.0
Identities = 635/1300 (48%), Positives = 830/1300 (63%), Gaps = 68/1300 (5%)
Query: 4 SKTVSERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIF 63
+ VS +YQ+++ EH+L+RPDTYIGS+E S+ W+ D + + K V VPGL+KIF
Sbjct: 71 NSNVSTQYQRLTPREHVLRRPDTYIGSIEPTTSEMWVFDSEKNKLDYKAVTYVPGLYKIF 130
Query: 64 DEILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHL 123
DEI+VNAADNKVRDP+M + V ++ E N I + N+GKGIP+EIHDKE IYIPELIFG+L
Sbjct: 131 DEIIVNAADNKVRDPNMNTLKVTLDPEANVISIYNNGKGIPIEIHDKEKIYIPELIFGNL 190
Query: 124 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHPPK 183
LTSSNYDD++KKVTGGRNGYGAKLCNIFSTEF++ETAD R KY Q W +NMS P
Sbjct: 191 LTSSNYDDNQKKVTGGRNGYGAKLCNIFSTEFVVETADKERMKKYKQTWYDNMSRKSEPV 250
Query: 184 ITSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKALKI 243
ITS KK YTK+ FKPDL +FGMDK+DDD+V +++RR+YD+ G+VR+ V LN + + I
Sbjct: 251 ITSLKKPDEYTKITFKPDLAKFGMDKIDDDMVSIIKRRIYDMAGTVRETKVYLNNERISI 310
Query: 244 RNFKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVSENS 303
FK YVE+YL S K PDE EP P ++YE +NDRW+VAFAVS+
Sbjct: 311 SGFKKYVEMYLASDTK-----------PDE---EP---PRVIYEHVNDRWDVAFAVSDGQ 353
Query: 304 FQQISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKKT--IKPFQIKNNMFIFINCLI 361
F+Q+SFVN+I+T GGTHVNYV ++I+ + + +KK+ K +K FQIKN + +F+NC I
Sbjct: 354 FKQVSFVNNISTIRGGTHVNYVANKIVDAIDEVVKKENKKAPVKAFQIKNYVQVFVNCQI 413
Query: 362 ENPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQLKKTDG 421
ENP+F SQTKE LTT+V FGS+C + +F+ I K+ + ++ + A A +QL K DG
Sbjct: 414 ENPSFDSQTKETLTTKVSAFGSQCTLSDKFLKAIKKSSVVEEVLKFATAKADQQLSKGDG 473
Query: 422 SRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGK 481
++RIT KLEDAN AGTKE +KC L+LTEGD RDYYG FPLRGK
Sbjct: 474 GLRSRITGLTKLEDANKAGTKESHKCVLILTEGDSAKSLAVSGLSVVGRDYYGVFPLRGK 533
Query: 482 MLNVREATPDQISKNAEIQAIKKIMGLQHKKRYEDTTTLRYGHIMIMTDQDHDGSHIKGL 541
+LNVREA+ QI N EIQAIKKIMG HKK Y D LRYGH+MIMTDQDHDGSHIKGL
Sbjct: 534 LLNVREASHSQILNNKEIQAIKKIMGFTHKKTYTDVKGLRYGHLMIMTDQDHDGSHIKGL 593
Query: 542 IINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWREEESHKYTW 601
IIN+LESS+P LL IPGFL + +FY +P+YE W+E ++ W
Sbjct: 594 IINYLESSYPSLLQIPGFLIQFITPIIKCTRGN---QVQAFYTLPEYEYWKEANNNGRGW 650
Query: 602 KQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWLKLY 661
K KYYKGLGTS + + YFS LD+H+K FHA+Q D++LI++AF+KKKAD RKEWL+ Y
Sbjct: 651 KIKYYKGLGTSDHDDMKSYFSDLDRHMKYFHAMQEKDAELIEMAFAKKKADVRKEWLRTY 710
Query: 662 EPGTVLDPKLTEIPISDFINKELILFSLADNIRSIPSVLDGLKPGQRKVIYACFKRNLKS 721
PG +D +IPI DFIN+ELI FS+ADNIRSIPSV+DGLKPGQRKV+Y CFKRNL
Sbjct: 711 RPGIYMDYTQPQIPIDDFINRELIQFSMADNIRSIPSVVDGLKPGQRKVVYYCFKRNLVH 770
Query: 722 EIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLKPNGAFGTRATGGKDS 781
E KV++L GYV+ T YHHGE S+ QTIV LAQ+FVGSNNI LL PNG FGTR+ GGK++
Sbjct: 771 ETKVSRLAGYVASETAYHHGEVSMEQTIVNLAQNFVGSNNINLLMPNGQFGTRSEGGKNA 830
Query: 782 AAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVIPMVLVNGTEGIGTGW 841
+A RY+ T L+ L R +FN+ DD LLNY D+ Q +EPE+Y+P++PMVLVNG EGIGTGW
Sbjct: 831 SASRYLNTALSPLARVLFNSNDDQLLNYQNDEGQWIEPEYYVPILPMVLVNGAEGIGTGW 890
Query: 842 STNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQKYRTYGRIEQIDENT 901
ST IP +NP DI N++ ++ GE +E M PWYRG++GS+ K+ P +Y+ G I QI EN
Sbjct: 891 STFIPNYNPKDITANLRHMLNGEPLEIMTPWYRGFRGSITKVAPDRYKISGIINQIGENK 950
Query: 902 LEITELPPKTWTSVIKEHLLLGLSGNDKVKPWIKDIQEQHG-ATIKFIITLTSDEMEKTR 960
+EITELP + WT +KE+L GL G +K++ +I D + HG + F +TLT M++
Sbjct: 951 VEITELPIRFWTQDMKEYLEAGLVGTEKIRKFIVDYESHHGEGNVHFNVTLTEAGMKEAL 1010
Query: 961 KIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYYTRLTYYQKRKDYIGERL 1020
+FKL T + SNM+AFD G+IKKYD V DIL++FY RL YQ+RK+++ L
Sbjct: 1011 NESLEVKFKLSRTQATSNMIAFDASGRIKKYDSVEDILTEFYEVRLRTYQRRKEHMVNEL 1070
Query: 1021 KWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGFPRINKEGKPTYGKVEEQAQ 1080
+ ++ S Q +FI MI+E +L VS K + L EL F I+K K +E +
Sbjct: 1071 EKRFDRFSNQARFIHMIIEGELVVSKKKKKDLIVELKEKKFQPISKPKKGHLVDLEVENA 1130
Query: 1081 IXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKFGNYDYLLGMKIWALTKERYEKLM 1140
+ +E Y+YLL M +W+LT ERY +L+
Sbjct: 1131 LAEEEQSGDV---------------------SQDEDSDAYNYLLSMPLWSLTYERYVELL 1169
Query: 1141 KQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKFIQYDEEVRNSIVPDAATTXXXXXX 1200
K+ E EL+ L+K + K+LW DLD F E N ++ D
Sbjct: 1170 KKKDEVMAELDALIKKTPKELWLHDLDAF-----------EHAWNKVMDDIQREMLEEEQ 1218
Query: 1201 XXXXXXXXXSKQPKKRARKSVKREYVDFERVLIEPRVIEKVKRVPKIKTENNDIVKKLSK 1260
K+P+ ++ + K PR I +K E + K S
Sbjct: 1219 SSRDFVNRTKKKPRGKSTGTRK------------PRAIAGSSSSTAVKKEASS-ESKPST 1265
Query: 1261 AKSTKQTTPEVKEDPEPTASHASTIFAKKADSVSKEPEED 1300
+QT E EP S I + +S EE+
Sbjct: 1266 TNRKQQTLLEFAASKEPEKSSDINIVKTEDNSHGLSVEEN 1305
>ECU04g0350 [B] KOG0355 DNA topoisomerase type II
Length = 1144
Score = 1097 bits (2837), Expect = 0.0
Identities = 584/1193 (48%), Positives = 776/1193 (64%), Gaps = 112/1193 (9%)
Query: 5 KTVSERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIFD 64
KT+ E YQK + +EHIL RPDTYIGSVE + + ++ DE M+ K++ VPGL+KIFD
Sbjct: 2 KTIEETYQKKTPVEHILLRPDTYIGSVEKEAQEMYVWDEENGRMVYKSIEYVPGLYKIFD 61
Query: 65 EILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLL 124
EI+VNAADNK+RDP M I V I+ E N I V N+GKGIPV IH +E +Y+PELIFG+LL
Sbjct: 62 EIIVNAADNKIRDPKMDVIKVSIDPEGNEISVYNNGKGIPVRIHKEENVYVPELIFGNLL 121
Query: 125 TSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHPPKI 184
TSSNY+DDEKKVTGGRNGYGAKLCNIFS EF++ETAD Y Q + +NM P+I
Sbjct: 122 TSSNYNDDEKKVTGGRNGYGAKLCNIFSKEFVVETADCEVKKYYRQRYRDNMGVKEDPEI 181
Query: 185 TSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKALKIR 244
+ Y KG +TK+ FKPDL+RF M +LDDDIV ++R+RVYD+ G V+DV + LN K ++++
Sbjct: 182 SRYTKG-DFTKITFKPDLRRFKMTRLDDDIVALLRKRVYDLAGIVKDVKIFLNEKRIEVK 240
Query: 245 NFKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVSENSF 304
FK YV+LY+ +++++ INDRWE+A SE F
Sbjct: 241 GFKEYVKLYIPPGA------------------------SVVHQVINDRWELALTTSEEQF 276
Query: 305 QQISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKK--TIKPFQIKNNMFIFINCLIE 362
QQ+SFVN I TT GGTHVN+V ++I+ + + ++K++K +++PFQ+++ MF+FIN LI+
Sbjct: 277 QQVSFVNGICTTKGGTHVNHVVERIVDPLVEAIQKKEKGLSVRPFQVRSCMFVFINSLID 336
Query: 363 NPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMK-TDLATKIFEIADENAHKQLKKTDG 421
NPAF SQTKE LT R FGSKCE +F+ I+K T + KI A +QLKKTDG
Sbjct: 337 NPAFDSQTKENLTLRASAFGSKCEPMGDFVKSIIKNTPIVQKITSFAKAKQSQQLKKTDG 396
Query: 422 SRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGK 481
++ +R++ PKLEDAN AGT CTL+LTEGD RD YG FPLRGK
Sbjct: 397 AKTSRLSGIPKLEDANFAGTSRSKDCTLILTEGDSAKTLAVAGLSVVGRDAYGVFPLRGK 456
Query: 482 MLNVREATPDQISKNAEIQAIKKIMGLQHKKRYEDTTTLRYGHIMIMTDQDHDGSHIKGL 541
+LNVREA+ QI +NAEI +IKKI+GLQH K YED ++LRYGH+MIMTDQDHDGSHIKGL
Sbjct: 457 LLNVREASHKQIMENAEISSIKKILGLQHNKVYEDVSSLRYGHVMIMTDQDHDGSHIKGL 516
Query: 542 IINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWREEESHKYTW 601
IINFL+ +P LL IPGFL K + F+ +P+YE++++ E W
Sbjct: 517 IINFLDHFYPSLLKIPGFLQEFITPIIRATK---KGQVRDFFTLPEYEEFKKNEDG---W 570
Query: 602 KQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWLKLY 661
KYYKGLGTST +A++YFS L H+K F L +D +LIDLAF+KKKAD RK WL +
Sbjct: 571 NIKYYKGLGTSTSADAKQYFSNLPVHVKSFTPLAAEDKELIDLAFNKKKADARKTWLLNF 630
Query: 662 EPGTVLDPKLTEIPISDFINKELILFSLADNIRSIPSVLDGLKPGQRKVIYACFKRNLKS 721
PGT LD T+I ISDF+NKELILFS+ADNIRSIPS++DGLKPGQRKVI++CFKRNL+S
Sbjct: 631 APGTFLDQSQTQISISDFVNKELILFSMADNIRSIPSLVDGLKPGQRKVIFSCFKRNLRS 690
Query: 722 EIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLKPNGAFGTRATGGKDS 781
EIKVAQL GYVSE + YHHGEQSL TIV LAQDFVGSNNI LL P G FG+R GGKD+
Sbjct: 691 EIKVAQLVGYVSEQSAYHHGEQSLCSTIVNLAQDFVGSNNINLLLPIGQFGSRLQGGKDA 750
Query: 782 AAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVIPMVLVNGTEGIGTGW 841
A+PRYIFT L+ LTR IFN DD +LNY+ DD ++EPE+Y+P+IPMVLVNG EGIGTGW
Sbjct: 751 ASPRYIFTSLSPLTRMIFNENDDAILNYLNDDNFSIEPEFYVPIIPMVLVNGAEGIGTGW 810
Query: 842 STNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQKYRTYGRIEQIDENT 901
ST+IP FNP+D+V N++R+++GE+ +M P+YR ++G++EKI K++ G E +
Sbjct: 811 STSIPNFNPVDVVENIRRMIRGEDPVEMVPYYRNFRGTIEKIGEGKFQVSGIYE--GDMD 868
Query: 902 LEITELPPKTWTSVIKEHLLLGLSGNDKVKPWI-KDIQEQH-GATIKFIITLTSDEMEKT 959
LEITELP TWT KE L V+ + +D +E H T+ F + L+
Sbjct: 869 LEITELPVGTWTLNYKEFL------ESLVQAGVARDFKEYHTEKTVSFTVKLSKP----- 917
Query: 960 RKIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYYTRLTYYQKRKDYIGER 1019
KL ST++++NMV FD +IKKY ++IL +FY RL YY RK+ + +
Sbjct: 918 -----VSNLKLNSTITVNNMVCFDENLRIKKYATPQEILKEFYGVRLRYYLIRKENMLKV 972
Query: 1020 LKWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGFPRINKEGKPTYGKVEEQA 1079
++ E+EKL +V+FI + +L +S + + + +L S G+ R +
Sbjct: 973 MREELEKLENKVRFIKEVSMGELVISRRRKGEVIFDLESRGYARAD-------------- 1018
Query: 1080 QIXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKFGNYDYLLGMKIWALTKERYEKL 1139
+Y+YLL M I +LT ER E+L
Sbjct: 1019 ---------------------------------------DYEYLLSMSILSLTVERIERL 1039
Query: 1140 MKQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKFI-----QYDEEVRNSI 1187
+ ++ +E +L+ + K+LW DL+ F + Y + +YD+E+ I
Sbjct: 1040 SNEHAKRLSEYNQLMGKTPKELWLEDLEVFEKEYLRIAENEAREYDDELNGCI 1092
>At3g23890 [B] KOG0355 DNA topoisomerase type II
Length = 1473
Score = 1061 bits (2745), Expect = 0.0
Identities = 588/1318 (44%), Positives = 804/1318 (60%), Gaps = 70/1318 (5%)
Query: 5 KTVSERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIFD 64
KT+ E YQK SQLEHIL RPDTYIGS+E W++++ D M+++ V VPGL+KIFD
Sbjct: 29 KTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYEK--DEMVQRPVTYVPGLYKIFD 86
Query: 65 EILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLL 124
EILVNAADNK RD M + VVI+ E+N I V N G G+PVEIH +EGIY+PE+IFGHLL
Sbjct: 87 EILVNAADNKQRDAKMDSVQVVIDVEQNLISVCNSGAGVPVEIHQEEGIYVPEMIFGHLL 146
Query: 125 TSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHPPKI 184
TSSNYDD+ KK TGGRNGYGAKL NIFSTEFI+ETAD R KY Q +ENNM P I
Sbjct: 147 TSSNYDDNVKKTTGGRNGYGAKLTNIFSTEFIIETADGKRLKKYKQVFENNMGKKSEPVI 206
Query: 185 TSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSV-RDVNVSLNGKALKI 243
T K ++TKV FKPDL++F M +L+DD+V +M +RV+DI G + + V V LNGK + +
Sbjct: 207 TKCNKSENWTKVTFKPDLKKFNMTELEDDVVALMSKRVFDIAGCLGKSVKVELNGKQIPV 266
Query: 244 RNFKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVSENS 303
++F +YV+LYL + K S ++P+ T E++NDRWEV ++SE
Sbjct: 267 KSFTDYVDLYLSAANK---------SRTEDPLPRLT-------EKVNDRWEVCVSLSEGQ 310
Query: 304 FQQISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKKT--IKPFQIKNNMFIFINCLI 361
FQQ+SFVNSIAT GGTHV+YVT QI + + K+ K +K +KN++++F+N LI
Sbjct: 311 FQQVSFVNSIATIKGGTHVDYVTSQITNHIVAAVNKKNKNANVKAHNVKNHLWVFVNALI 370
Query: 362 ENPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQLKKTDG 421
+NPAF SQTKE LT R FGSKCE+ +F+ K+ K+ + + AD +K LKK+DG
Sbjct: 371 DNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVGKSGVVENLLSWADFKQNKDLKKSDG 430
Query: 422 SRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGK 481
++ R+ KL+DA AG K CTL+LTEGD +Y G FPLRGK
Sbjct: 431 AKTGRVL-VEKLDDAAEAGGKNSRLCTLILTEGDSAKSLALAGRSVLGNNYCGVFPLRGK 489
Query: 482 MLNVREATPDQISKNAEIQAIKKIMGLQHKKRYEDTTTLRYGHIMIMTDQDHDGSHIKGL 541
+LNVREA+ QI+ N EI+ +KKI+GL+ +YE+ +LRYG +MIMTDQDHDGSHIKGL
Sbjct: 490 LLNVREASTTQITNNKEIENLKKILGLKQNMKYENVNSLRYGQMMIMTDQDHDGSHIKGL 549
Query: 542 IINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWREEESHKYT- 600
+INF+ S +P LL +P FL KK +SFY+MP+YE+W+E T
Sbjct: 550 LINFIHSFWPSLLQVPSFLVEFITPIVKATRKGTKK-VLSFYSMPEYEEWKESLKGNATG 608
Query: 601 WKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWLKL 660
W KYYKGLGTST +E +EYFS L H K F D + I+LAFSKKK + RK WL
Sbjct: 609 WDIKYYKGLGTSTAEEGKEYFSNLGLHKKDFVWEDEQDGEAIELAFSKKKIEARKNWLSS 668
Query: 661 YEPGTVLDPKLTEIPISDFINKELILFSLADNIRSIPSVLDGLKPGQRKVIYACFKRNLK 720
Y PG LD + ++ SDF+NKELILFS+AD RSIPS++DGLKPGQRK+++ FK+ +
Sbjct: 669 YVPGNHLDQRQPKVTYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFVAFKKIAR 728
Query: 721 SEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLKPNGAFGTRATGGKD 780
E+KVAQL GYVS + YHHGEQSL I+G+AQD+VGSNNI LL PNG FGTR +GGKD
Sbjct: 729 KEMKVAQLVGYVSLLSAYHHGEQSLASAIIGMAQDYVGSNNINLLLPNGQFGTRTSGGKD 788
Query: 781 SAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVIPMVLVNGTEGIGTG 840
SA+ RYIFT+L+ +TR +F DD LL+Y+ +D Q +EP WY+P+IP VLVNG EGIGTG
Sbjct: 789 SASARYIFTKLSPVTRILFPKDDDLLLDYLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTG 848
Query: 841 WSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQK----YRTYGRIEQ 896
WST IP +NP +IV NV+RL+ GE M M PWYRG++G++EK ++ Y G E+
Sbjct: 849 WSTFIPNYNPREIVANVRRLLNGESMVPMDPWYRGFKGTIEKTASKEGGCTYTITGLYEE 908
Query: 897 IDENTLEITELPPKTWTSVIKEHLLLGLSGNDKVKPWIKDIQEQHG-ATIKFIITLTSDE 955
+DE T+ ITELP + W K L D P+ +D++ + ++ F + L+ +
Sbjct: 909 VDETTIRITELPIRRWNDDYKN--FLQSLKTDNGAPFFQDVKAYNDEKSVDFDLILSEEN 966
Query: 956 MEKTRKIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYYTRLTYYQKRKDY 1015
M R+ GF ++FKL +T++ SNM FD +G IKKY IL +F+ R YY+KRK+
Sbjct: 967 MLAARQEGFLKKFKLTTTIATSNMHLFDKKGVIKKYVTPEQILEEFFDLRFEYYEKRKET 1026
Query: 1016 IGERLKWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGFPRINKEGKPT---- 1071
+ + ++ E+ KL + +FI+ ++ ++ V+ + + + E+L GF ++ +
Sbjct: 1027 VVKNMEIELLKLENKARFILAVLSGEIIVNKRKKADIVEDLRQKGFTPFPRKAESVEAAI 1086
Query: 1072 YGKVEEQAQIXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKFGNYDYLLGMKIWAL 1131
G V++ A + G E YDYLL M I +L
Sbjct: 1087 AGAVDDDA-------------AEEPEEILVDPESSSSYIPGSE-----YDYLLAMAIASL 1128
Query: 1132 TKERYEKLMKQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKFIQYDEEVRNSIVPDA 1191
T E+ E+L+ + + + K + K LW DL+ + EK D +V+ +I
Sbjct: 1129 TIEKVEELLADRDKMIIAVADMKKTTPKSLWLSDLESLDKELEKLDLKDAQVQQAIEAAQ 1188
Query: 1192 ATTXXXXXXXXXXXXXXXSK-QPKKRARKSVKREYVD--FERVLIEPRVIEKVKRVPKIK 1248
K PKK +K+ + E + + + + V E VK PK +
Sbjct: 1189 KKIRAKSGAAVKVKRQAPKKPAPKKTTKKASESETTEASYSAMDTDNNVAEVVK--PKAR 1246
Query: 1249 TENNDIVKKLSKAKSTK------QTTPEVKEDPEPTASHASTIFAKKADSVSKEPEED 1300
KK S++++T+ T V E +P + KKA + +KE EED
Sbjct: 1247 ---QGAKKKASESETTEASHSAMDTDNNVAEVVKPKGRQGA---KKKAPAAAKEVEED 1298
>Hs19913408 [B] KOG0355 DNA topoisomerase type II
Length = 1621
Score = 1041 bits (2691), Expect = 0.0
Identities = 562/1198 (46%), Positives = 754/1198 (62%), Gaps = 63/1198 (5%)
Query: 6 TVSERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIFDE 65
+V YQK +QLEHIL RPDTYIGSVE W++DE M + V VPGL+KIFDE
Sbjct: 45 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDE 103
Query: 66 ILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLLT 125
ILVNAADNK RD +M I V I+ E N I + N+GKGIPV H E +Y+P LIFG LLT
Sbjct: 104 ILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLT 163
Query: 126 SSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHPPKIT 185
SSNYDDDEKKVTGGRNGYGAKLCNIFST+F +ETA H + Q W NNM KI
Sbjct: 164 SSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIK 223
Query: 186 SYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKALKIRN 245
+ G YT + F+PDL +F M+KLD DIV +M RR YD+ GS R V V NGK L +
Sbjct: 224 HFD-GEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNG 282
Query: 246 FKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVSENSFQ 305
F++YV+LY+K + + E +++E N+RW+V +SE FQ
Sbjct: 283 FRSYVDLYVK-----------------DKLDETGVALKVIHELANERWDVCLTLSEKGFQ 325
Query: 306 QISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKK---TIKPFQIKNNMFIFINCLIE 362
QISFVNSIATT GG HV+YV DQ++ K+ + +KK+ K ++KPFQ+KN++++FINCLIE
Sbjct: 326 QISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIE 385
Query: 363 NPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQLKKTDGS 422
NP F SQTKE +T + K FGSKC++ +F + I A QL K S
Sbjct: 386 NPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSS 445
Query: 423 RK-NRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGK 481
K ++I PKL+DAN AG K +CTL+LTEGD RD YG FPLRGK
Sbjct: 446 VKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGK 505
Query: 482 MLNVREATPDQISKNAEIQAIKKIMGLQHKKRYEDTT---TLRYGHIMIMTDQDHDGSHI 538
+LNVREA+ QI +NAEI I KI+GLQ+KK Y+D TLRYG IMIMTDQD DGSHI
Sbjct: 506 ILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHI 565
Query: 539 KGLIINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWREEESHK 598
KGL+INF+ ++P LL GFL + K+ +SFY++P++++W++ ++
Sbjct: 566 KGLLINFIHHNWPSLLK-HGFLEEFITPIVKASKN---KQELSFYSIPEFDEWKKHIENQ 621
Query: 599 YTWKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWL 658
WK KYYKGLGTST +EA+EYF+ +++H F +D I LAFSKKK DDRKEWL
Sbjct: 622 KAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWL 681
Query: 659 KLYE-----------PGTVLDPKLTE-IPISDFINKELILFSLADNIRSIPSVLDGLKPG 706
+ P L T+ + +DFINKELILFS +DN RSIPS++DG KPG
Sbjct: 682 TNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPG 741
Query: 707 QRKVIYACFKRNLKSEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLK 766
QRKV++ CFKRN K E+KVAQL G V+E + YHHGEQ+L TIV LAQ+FVGSNNI LL+
Sbjct: 742 QRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQ 801
Query: 767 PNGAFGTRATGGKDSAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVI 826
P G FGTR GGKD+A+PRYIFT L+ L R +F +DD LL ++ DD Q VEPEWY+P+I
Sbjct: 802 PIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPII 861
Query: 827 PMVLVNGTEGIGTGWSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQ 886
PMVL+NG EGIGTGW+ +P ++ +IVNNV+R++ G + M P Y+ ++G+++++
Sbjct: 862 PMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQN 921
Query: 887 KYRTYGRIEQIDENTLEITELPPKTWTSVIKEHLLLG-LSGNDKVKPWIKDIQEQH-GAT 944
+Y G I +D NT+EITELP +TWT V KE +L L+G DK I D +E H T
Sbjct: 922 QYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTT 981
Query: 945 IKFIITLTSDEMEKTRKIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYYT 1004
+KF++ +T +++ + G ++ FKL +T++ ++MV FD G +KKY+ V+DIL +F+
Sbjct: 982 VKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDL 1041
Query: 1005 RLTYYQKRKDYIGERLKWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGFPRI 1064
RL+YY RK+++ L E KL+ Q +FI+ ++ K+++ N+ + L + L+ G+
Sbjct: 1042 RLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGY--- 1098
Query: 1065 NKEGKPTYGKVEEQAQIXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKFGNYDYLL 1124
E P E Q + +GP+ ++Y+L
Sbjct: 1099 --ESDPVKAWKEAQEK---------AAEEDETQNQHDDSSSDSGTPSGPD-----FNYIL 1142
Query: 1125 GMKIWALTKERYEKLMKQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKFIQYDEE 1182
M +W+LTKE+ E+L+KQ K E+ L + S DLW+ DL FVE +K + E
Sbjct: 1143 NMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQERE 1200
>Hs19913406 [B] KOG0355 DNA topoisomerase type II
Length = 1531
Score = 1034 bits (2673), Expect = 0.0
Identities = 572/1276 (44%), Positives = 769/1276 (59%), Gaps = 87/1276 (6%)
Query: 6 TVSERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIFDE 65
+V YQK +QLEHIL RPDTYIGSVE+ Q W++DE + V VPGL+KIFDE
Sbjct: 29 SVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDVGINYRE-VTFVPGLYKIFDE 87
Query: 66 ILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLLT 125
ILVNAADNK RDP M I V I+ E N I + N+GKGIPV H E +Y+P LIFG LLT
Sbjct: 88 ILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLT 147
Query: 126 SSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHPPKIT 185
SSNYDDDEKKVTGGRNGYGAKLCNIFST+F +ETA + Q W +NM ++
Sbjct: 148 SSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELK 207
Query: 186 SYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKALKIRN 245
+ G YT + F+PDL +F M LD DIV +M RR YDI GS +DV V LNG L ++
Sbjct: 208 PFN-GEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKG 266
Query: 246 FKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVSENSFQ 305
F++YV++YLK + + E +++E++N RWEV +SE FQ
Sbjct: 267 FRSYVDMYLK-----------------DKLDETGNSLKVIHEQVNHRWEVCLTMSEKGFQ 309
Query: 306 QISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKK---TIKPFQIKNNMFIFINCLIE 362
QISFVNSIAT+ GG HV+YV DQI+ K+ D +KK+ K +K Q+KN+M+IF+N LIE
Sbjct: 310 QISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALIE 369
Query: 363 NPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQL-KKTDG 421
NP F SQTKE +T + K FGS C++ +FI + + I A QL KK
Sbjct: 370 NPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCSA 429
Query: 422 SRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGK 481
+ NRI PKL+DAN AG + +CTL+LTEGD RD YG FPLRGK
Sbjct: 430 VKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRGK 489
Query: 482 MLNVREATPDQISKNAEIQAIKKIMGLQHKKRYEDTT---TLRYGHIMIMTDQDHDGSHI 538
+LNVREA+ QI +NAEI I KI+GLQ+KK YED TLRYG IMIMTDQD DGSHI
Sbjct: 490 ILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSHI 549
Query: 539 KGLIINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWREEESHK 598
KGL+INF+ ++P LL FL + K+ ++FY++P++E+W+ +
Sbjct: 550 KGLLINFIHHNWPSLLR-HRFLEEFITPIVKVSKN---KQEMAFYSLPEFEEWKSSTPNH 605
Query: 599 YTWKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWL 658
WK KYYKGLGTST +EA+EYF+ + +H +F +D I LAFSKK+ DDRKEWL
Sbjct: 606 KKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWL 665
Query: 659 KLYEPGT------------VLDPKLTEIPISDFINKELILFSLADNIRSIPSVLDGLKPG 706
+ + T + +DFINKELILFS +DN RSIPS++DGLKPG
Sbjct: 666 TNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPG 725
Query: 707 QRKVIYACFKRNLKSEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLK 766
QRKV++ CFKRN K E+KVAQL G V+E + YHHGE SL TI+ LAQ+FVGSNN+ LL+
Sbjct: 726 QRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQ 785
Query: 767 PNGAFGTRATGGKDSAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVI 826
P G FGTR GGKDSA+PRYIFT L+ L R +F DD L ++ DD Q VEPEWY+P+I
Sbjct: 786 PIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPII 845
Query: 827 PMVLVNGTEGIGTGWSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQ 886
PMVL+NG EGIGTGWS IP F+ +IVNN++RLM GEE M P Y+ ++G++E++ P
Sbjct: 846 PMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPN 905
Query: 887 KYRTYGRIEQIDENTLEITELPPKTWTSVIKEHLLLG-LSGNDKVKPWIKDIQEQH-GAT 944
+Y G + ++ T+EI+ELP +TWT KE +L L+G +K P I D +E H T
Sbjct: 906 QYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTT 965
Query: 945 IKFIITLTSDEMEKTRKIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYYT 1004
+KF++ +T +++ + ++G ++ FKL ++++ ++MV FD G +KKYD V DIL DF+
Sbjct: 966 VKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFEL 1025
Query: 1005 RLTYYQKRKDYIGERLKWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGFPRI 1064
RL YY RK+++ L E KL+ Q +FI+ ++ K+ + NKP+ L + L+ G+
Sbjct: 1026 RLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGY--- 1082
Query: 1065 NKEGKPTYGKVEEQAQIXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKFGNYDYLL 1124
+ P E Q ++ +GP ++YLL
Sbjct: 1083 --DSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTD------SGP-----TFNYLL 1129
Query: 1125 GMKIWALTKERYEKLMKQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKFIQYDEEVR 1184
M +W LTKE+ ++L + EK+ EL+ L + S DLW+ DL F+E E +++
Sbjct: 1130 DMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDE 1189
Query: 1185 NSIVPDAATTXXXXXXXXXXXXXXXSKQPKKRARKSVKREYVD-------FERVLIEPRV 1237
+P K K + +K+ E + R+ IE +
Sbjct: 1190 QVGLP--------------------GKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKA 1229
Query: 1238 IEKVKRVPKIKTENND 1253
+ K KIK EN +
Sbjct: 1230 EAEKKNKKKIKNENTE 1245
>CE06184 [B] KOG0355 DNA topoisomerase type II
Length = 1520
Score = 1018 bits (2632), Expect = 0.0
Identities = 568/1331 (42%), Positives = 788/1331 (58%), Gaps = 71/1331 (5%)
Query: 2 TQSKTVSERYQKISQLEHILKRPDTYIGSVE-VQESQQWIHDETTDCMIEKTVNIVPGLF 60
++ + + YQK SQLEHIL RPDTYIGSVE +++ W+++ + ++ ++ VPGL+
Sbjct: 58 SKQMAIEDIYQKKSQLEHILLRPDTYIGSVEHTEKTPMWVYNMEESKLEQRDISYVPGLY 117
Query: 61 KIFDEILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIF 120
KI+DEILVNAADNK RDP M I + IN+E+N I V N+GKGIPV H E +Y+PELIF
Sbjct: 118 KIYDEILVNAADNKQRDPKMNTIKITINKEKNEISVYNNGKGIPVTQHKVEKVYVPELIF 177
Query: 121 GHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCH 180
G LLTSSNY+DDEKKVTGGRNGYGAKLCNIFST+F LET+ + Q W NM+
Sbjct: 178 GTLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTKFTLETSSRDYKSAFKQTWIKNMTRDE 237
Query: 181 PPKITSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKA 240
PKI +TK+ F PDL +F M +LDDDI +M RR YD+ GS + V V LNGK
Sbjct: 238 EPKIVK-STDEDFTKITFSPDLAKFKMKELDDDICHLMARRAYDVAGSSKGVAVFLNGKR 296
Query: 241 LKIRNFKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVS 300
+ I+ F++YV++Y + EP++ I YE++ DRW+VA A+S
Sbjct: 297 IPIKGFEDYVQMYTSQF-----------NNEGEPLK-------IAYEQVGDRWQVALALS 338
Query: 301 ENSFQQISFVNSIATTSGGTHVNYVTDQIIKKVSDRLK----KQKKTIKPFQIKNNMFIF 356
E FQQ+SFVNSIATT GG HV+YV DQ++ K D +K K IKPFQIKN+M++F
Sbjct: 339 EKGFQQVSFVNSIATTKGGRHVDYVADQMVAKFIDSIKRKLTKTSMNIKPFQIKNHMWVF 398
Query: 357 INCLIENPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQL 416
+NCLIENP F SQTKE +T + K FGS C + +F + + L
Sbjct: 399 VNCLIENPTFDSQTKETMTLQQKQFGSTCVLSEKFSKAASSVGITDAVMSWVRFKQMDDL 458
Query: 417 -KKTDGSRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGC 475
KK ++ +++ PKLEDAN AGTK +CTL+LTEGD RD YG
Sbjct: 459 NKKCSKTKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGV 518
Query: 476 FPLRGKMLNVREATPDQISKNAEIQAIKKIMGLQHKKRYE---DTTTLRYGHIMIMTDQD 532
FPLRGK+LNVRE QI+ NAE+ A+ KI+GLQ+KK+YE D TLRYG +M+M DQD
Sbjct: 519 FPLRGKLLNVREGNMKQIADNAEVNAMIKILGLQYKKKYETEDDFKTLRYGKLMVMADQD 578
Query: 533 HDGSHIKGLIINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWR 592
DGSHIKGL+INF+ +P L+ F+ KE +SFY++P+Y +WR
Sbjct: 579 QDGSHIKGLVINFIHHFWPSLIQ-RNFVEEFITPIVKATKG---KEEVSFYSLPEYSEWR 634
Query: 593 EEESHKYTWKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKAD 652
+ ++K KYYKGLGTST +EA+EYF + +H +F DD +D+AFSKKK +
Sbjct: 635 MNTDNWKSYKIKYYKGLGTSTSKEAKEYFLDMVRHRIRFKYNGADDDNAVDMAFSKKKIE 694
Query: 653 DRKEWLKLY--EPGTVLDPKLTE----------IPISDFINKELILFSLADNIRSIPSVL 700
+RK+WL + E L E + DF+N+EL+LFS DN RSIP ++
Sbjct: 695 ERKDWLSKWMREKKDRKQQGLAEEYLYNKDTRFVTFKDFVNRELVLFSNLDNERSIPCLV 754
Query: 701 DGLKPGQRKVIYACFKRNLKSEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSN 760
DG KPGQRKV++ACFKR K E+KVAQL G V+E + YHHGEQSL TIV LAQD+VGSN
Sbjct: 755 DGFKPGQRKVLFACFKRADKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVGSN 814
Query: 761 NIYLLKPNGAFGTRATGGKDSAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPE 820
NI LL P G FGTR GGKDSA+ RYIFT+L+ +TR +F DD +L ++ ++ Q +EPE
Sbjct: 815 NINLLLPIGQFGTRLQGGKDSASARYIFTQLSPVTRTLFPAHDDNVLRFLYEENQRIEPE 874
Query: 821 WYLPVIPMVLVNGTEGIGTGWSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSL 880
WY P+IPMVLVNG +GIGTGWSTNIP +NP ++V N+KRL+ GE + +APWY+ ++G +
Sbjct: 875 WYCPIIPMVLVNGAQGIGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRGKI 934
Query: 881 EKIDPQKYRTYGRIEQIDENTLEITELPPKTWTSVIKEHLLLGL-SGNDKVKPWIKDIQE 939
+IDP ++ YG + +D+NT+EITELP K WT KE +L GL +DK P I D +E
Sbjct: 935 IQIDPSRFACYGEVAVLDDNTIEITELPIKQWTQDYKEKVLEGLMESSDKKSPVIVDYKE 994
Query: 940 QH-GATIKFIITLTSDEM-EKTRKIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDI 997
H T+KF++ L+ ++ E R ++ FKL + ++ + MV FD G ++ Y I
Sbjct: 995 YHTDTTVKFVVKLSPGKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGCLRTYTSPEAI 1054
Query: 998 LSDFYYTRLTYYQKRKDYIGERLKWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELM 1057
+FY +R Y +RK+Y+ L+ + ++L+ Q +FI+ + ++ + NK + + + L+
Sbjct: 1055 TQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILAKINNEIVLENKKKAAIVDVLI 1114
Query: 1058 SLGFPRINKEGKPT-YGKVEEQAQIXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEK 1116
+ F + P K E++ + E K
Sbjct: 1115 KMKF-----DADPVKKWKEEQKLKELRESGEIELDEDDLAAVAVEEDEAISSAAKAVETK 1169
Query: 1117 FGNYDYLLGMKIWALTKERYEKLMKQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKF 1176
+YDYL+GM + L++E KL+K+ +EK E+ + K + +DLW DLD+FV +K
Sbjct: 1170 LSDYDYLVGMALIKLSEEEKNKLIKESEEKMAEVRVIEKKTWQDLWHEDLDNFVSELDK- 1228
Query: 1177 IQYDEEVRNSIVPDAATTXXXXXXXXXXXXXXXSKQPKKRARKSVKREYVDFERVLIEPR 1236
+E R DA+ + PKK V D +R IEP
Sbjct: 1229 ----QEAREKADQDAS---IKNAAKKLAADAKTGRGPKKNVCTEVLPS-KDGQR--IEPM 1278
Query: 1237 VIEKVK-RVPKIKTENNDIVKKLSK----AKSTKQTTPEVKEDPEPTASHASTIFAKKAD 1291
+ K + K+ + VKK K K K+ ++K+ P A T +K+D
Sbjct: 1279 LDAATKAKYEKMSQPKKERVKKEPKEPKEPKKVKKEGQDIKKFMSPAA--PKTAKKEKSD 1336
Query: 1292 SVSKEPEEDND 1302
+ + E++D
Sbjct: 1337 GFNSDMSEESD 1347
>7298585 [B] KOG0355 DNA topoisomerase type II
Length = 1423
Score = 1014 bits (2621), Expect = 0.0
Identities = 577/1333 (43%), Positives = 785/1333 (58%), Gaps = 113/1333 (8%)
Query: 6 TVSERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIFDE 65
++ + YQK SQLEHIL RPD+YIGSVE + W++D + + M++K ++ VPGL+KIFDE
Sbjct: 9 SIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDE 68
Query: 66 ILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLLT 125
ILVNAADNK RD SM I + I+ E N + V N+G+GIPV +H ++ +Y+P +IFGHLLT
Sbjct: 69 ILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLT 128
Query: 126 SSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHPPKIT 185
SSNY+DDEKKVTGGRNGYGAKLCNIFST F +ETA + Q W NNM +I
Sbjct: 129 SSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIK 188
Query: 186 SYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKALKIRN 245
+ G YT++ F PDL +F MD+LD+DIV +M RR YD+ S + V+V LNG L I
Sbjct: 189 DFN-GTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLGI-- 245
Query: 246 FKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVSENSFQ 305
++E N+RWEVA S+ FQ
Sbjct: 246 ---------------------------------------VHEVANERWEVACCPSDRGFQ 266
Query: 306 QISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKK---TIKPFQIKNNMFIFINCLIE 362
Q+SFVNSIAT GG HV++V D +IK++ + LKK+ K IKPFQ++N++++F+NCLIE
Sbjct: 267 QVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKKNKGGINIKPFQVRNHLWVFVNCLIE 326
Query: 363 NPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQLKKTDGS 422
NP F SQTKE +T + K FGSKC + +FIN + K+ + + A A + KT G
Sbjct: 327 NPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGR 386
Query: 423 RKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGKM 482
+ ++I PKLEDAN AG K KCTL+LTEGD RD YG FPLRGK+
Sbjct: 387 KSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKL 446
Query: 483 LNVREATPDQISKNAEIQAIKKIMGLQHKKRY---EDTTTLRYGHIMIMTDQDHDGSHIK 539
LNVREA Q+S+NAEI + KI+GLQ+KK+Y +D TLRYG +MIMTDQD DGSHIK
Sbjct: 447 LNVREANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLKTLRYGKVMIMTDQDQDGSHIK 506
Query: 540 GLIINFLESSFPGLLDIPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWREEESHKY 599
GL+INF+ +++P LL +P FL K E +SFY++P++E+W+ + ++ +
Sbjct: 507 GLLINFIHTNWPELLRLP-FLEEFITPIVKATK---KNEELSFYSLPEFEEWKNDTANHH 562
Query: 600 TWKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWL- 658
T+ KYYKGLGTST +EA+EYF +D+H F D + I +AFSKK + RK WL
Sbjct: 563 TYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVWLT 622
Query: 659 ----------KLYEPGTVLDPKLTE-IPISDFINKELILFSLADNIRSIPSVLDGLKPGQ 707
+L P L K T+ I +DFIN EL+LFS ADN RSIPS++DGLKPGQ
Sbjct: 623 NHMDEVKRRKELGLPERYLYTKGTKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQ 682
Query: 708 RKVIYACFKRNLKSEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLKP 767
RKV++ CFKRN K E+KVAQL G V+E + YHHGE SL TIV LAQ+FVG+NNI LL+P
Sbjct: 683 RKVMFTCFKRNDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEP 742
Query: 768 NGAFGTRATGGKDSAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVIP 827
G FGTR +GGKD A+ RYIFT ++ LTR I++ LDDPLL+Y DD Q +EP WYLP+IP
Sbjct: 743 RGQFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIP 802
Query: 828 MVLVNGTEGIGTGWSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQK 887
MVLVNG EGIGTGWST I +NP +I+ N+++++ G+E M PWY+ + G +E + +
Sbjct: 803 MVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGR 862
Query: 888 YRTYGRIEQIDENTLEITELPPKTWTSVIKEHLLLGLS-GNDKVKPWIKDIQEQH-GATI 945
Y G I+ + N LEI+ELP WT KE++L LS G +KVK I + +E H T+
Sbjct: 863 YIQTGNIQILSGNRLEISELPVGVWTQNYKENVLEPLSNGTEKVKGIISEYREYHTDTTV 922
Query: 946 KFIITLTSDEMEK--TRKIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYY 1003
+F+I+ E E+ + GFY FKL +T+S + M AFD ++++ DIL ++Y
Sbjct: 923 RFVISFAPGEFERIHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYK 982
Query: 1004 TRLTYYQKRKDYIGERLKWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGF-P 1062
R YY +R+D++ +L + ++LS Q +FI+ EKKL V NK R + +EL+ G+ P
Sbjct: 983 LRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGYRP 1042
Query: 1063 RINKEGKPTYGKVEEQAQIXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKF----- 1117
KE + K+E+ Q PE+ F
Sbjct: 1043 DPVKEWQRRI-KMEDAEQADEEDEEEEEAAPSVSSKAKKEKEV------DPEKAFKKLTD 1095
Query: 1118 -GNYDYLLGMKIWALTKERYEKLMKQMQEKQTELERLLKLSAKDLWEIDLDDFVEHYEKF 1176
+DYLLGM +W LT+E+ +L+KQ K +ELE L K + + LW LDD K
Sbjct: 1096 VKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTPEMLW---LDDLDALESKL 1152
Query: 1177 IQYDEEVRNSIVPDAATTXXXXXXXXXXXXXXXSKQPKKRARKSV------KREYVDFER 1230
+ +E+ R A S K R KS+ + D +
Sbjct: 1153 NEVEEKER-------AEEQGINLKTAKALKGQKSASAKGRKVKSMGGGAGAGDVFPDPDG 1205
Query: 1231 VLIEPRVIEKVKRVPKIKTENNDIVKKLSKAKSTKQTTPEVKEDPEPTASHASTIFAKKA 1290
+E ++ E +I+KK++ A Q E K+ EP K
Sbjct: 1206 EPVEFKITE-------------EIIKKMAAAAKVAQAAKEPKKPKEPKEPKVKK--EPKG 1250
Query: 1291 DSVSKEPEEDNDE 1303
+ EP+ DE
Sbjct: 1251 KQIKAEPDASGDE 1263
>CE25068 [B] KOG0355 DNA topoisomerase type II
Length = 1114
Score = 715 bits (1845), Expect = 0.0
Identities = 443/1170 (37%), Positives = 643/1170 (54%), Gaps = 108/1170 (9%)
Query: 39 WIHDETTDCMIEKTVNIVPGLFKIFDEILVNAADNKVRDPSMKKIDVVINQEENTIEVKN 98
W+ D MI K V PGL KIFDEILVNAADNK RD SM +++V +++E I V N
Sbjct: 8 WLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWN 67
Query: 99 DGKGIPVEIHDKEGIYIPELIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILE 158
+G G+PVEIH EGIY+P L+FG+L TSSNYDD E K GGRNGYGAKLCNIFS EFI+E
Sbjct: 68 NGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVE 127
Query: 159 TADPSRGHKYIQNWENNMSTCHPPKITSY--KKGPSYTKVIFKPDLQRFGMDKLDDDIVG 216
T D ++ Q W +NM C+ ++ + YTKV F PDL+RF +DKL DD++
Sbjct: 128 TVDTRIKRRFRQKWYDNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVID 187
Query: 217 VMRRRVYDINGSV-RDVNVSLNGKALKIRNFKNYVELYLKSLEKIKLNRLRESSTPDEPM 275
++ RRV+++ ++ RDV+V LNG+ + F++YV+++ S
Sbjct: 188 LIGRRVFEVAATLPRDVDVYLNGQKCDVDGFEDYVKMFNDS------------------- 228
Query: 276 QEPTKIPTILYERINDRWEVAFAVSENSFQQ--------ISFVNSIATTSGGTHVNYVTD 327
++L+ RW V A N F + +SFVN+I T GG+HV+YV D
Sbjct: 229 ------SSLLFLHPTPRWHVGVAKRNNFFGESHVVLPKIVSFVNNINTEKGGSHVDYVMD 282
Query: 328 QIIK----KVSDRLKKQKKTIKPFQIKNNMFIFINCLIENPAFTSQTKEQLTTRVKDFGS 383
+I+ V +L K++KP IKNN+ IFINCLIENP+F SQTKE LTT+ K+FGS
Sbjct: 283 KIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGS 342
Query: 384 KCEVPSEFINKIMKTDLATKIFEIADENAHKQLKKTDGSR--KNRITEYPKLEDANMAG- 440
E ++ + + I +I +E + + KK G R + + + KLEDA AG
Sbjct: 343 IFECDAK--KTAEWAEQSGLIEDIVEEVLNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGI 400
Query: 441 TKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGKMLNVREATPDQISKNAEIQ 500
T KCTL+LTEGD R+ YG FPL+GK+LNV + SKN EI
Sbjct: 401 TGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEIS 460
Query: 501 AIKKIMGLQHKKRYEDT-TTLRYGHIMIMTDQDHDGSHIKGLIINFLESSFPGLLDIPGF 559
+ +I+GL+ + T +LRYG ++I+ DQD DGSHIKGLI+NF+ +P L+ GF
Sbjct: 461 NLLRILGLKFEDSNSITRESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGF 520
Query: 560 LXXXXXXXXXXXXSRPKKETISFYNMPDYEKWRE-EESHKYTWKQKYYKGLGTSTQQEAR 618
+ ++ + SF++M +Y KW + EE K WK KYYKGLGTST EAR
Sbjct: 521 I---QSFRTPLLKAKKGDKVRSFFSMNEYRKWADVEEGGK--WKIKYYKGLGTSTSNEAR 575
Query: 619 EYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWLKLYEPG-TVLDPKLTEIPIS 677
EYFS LD H F D I +AF + K+D+RKEW++ E T D + + +S
Sbjct: 576 EYFSDLDHHTVNFKYTGTTDDDAIRMAFDRDKSDERKEWIRRSENEITNEDDEQKKARMS 635
Query: 678 DFINKELILFSLADNIRSIPSVLDGLKPGQRKVIYACFKR-NLKSEIKVAQLGGYVSEHT 736
D + ++L F + I+SIPS++DGLKP QRK+++ + +EIKV+QL G V+
Sbjct: 636 DGV-EDLQRFE-SQRIQSIPSLIDGLKPSQRKILWTLLNNMDESTEIKVSQLAGAVAHRQ 693
Query: 737 GYHHGEQSLYQTIVGLAQDFVGSNNIYLLKPNGAFGTRATGGKDSAAPRYIFTELNKLTR 796
YHHGE+SL +TI+ + Q F GS+N+ LL+P G FGTR GG D+A+ RYIFT L TR
Sbjct: 694 SYHHGEESLVRTIIRMGQTFCGSSNLPLLQPIGQFGTRHEGGNDAASARYIFTALAPTTR 753
Query: 797 KIFNTLDDPLLNYIQDDEQTVEPEWYLPVIPMVLVNGTEGIGTGWSTNIPPFNPMDIVNN 856
+F DD LL ++ VEP P++P++L+NGTEGIGTGWST I NP+DI++
Sbjct: 754 LLFPQADDDLLQKNVEEGMVVEPT-LCPIVPLILINGTEGIGTGWSTKIANRNPIDIIDM 812
Query: 857 VKRLMKGEEME-QMAPWYRGWQGSLEKIDPQKYRTYGRIEQIDEN-------TLEITELP 908
++R + E ++ P+Y ++G LE + P K+ + G+I+ I ++EI ELP
Sbjct: 813 IRRKIDSISTEYEIPPFYEEFRGKLEVVTPTKFISSGKIQLIRPERKNASTFSIEIVELP 872
Query: 909 PKTWTSVIKEHLLLGLSGNDKVKPWIKDIQEQHGATIKFIITL---TSDEMEKTRKIGFY 965
WTS KE LS + P ++ + + F ITL S +
Sbjct: 873 IGIWTSKYKEK----LSKIVETLPVLEFSERHTEKRVHFRITLDRKKSSRFLQKSNSDLL 928
Query: 966 ERFKLVSTVSLSNMVAFDPQGKIKKYDDVRDILSDFYYTRLTYYQKRKDYIGERLKWEVE 1025
FKL ++++ N V FD G++K++ ++ +I ++F+ R Y+KR E + ++
Sbjct: 929 NYFKLRTSLT-ENRVLFDRNGELKEFGNISEIAAEFFEVRRDLYEKRLKIQKEECEAKLI 987
Query: 1026 KLSYQVKFIMMIVEKKLSVSNKPRPVLFEELMSLGFPRINKEGKPTYGKVEEQAQIXXXX 1085
+ Q+ FI M+ + + + R L E+L +GF +V+ A I
Sbjct: 988 YVENQLNFIEMVTNGTIEIRSMGRNQLEEKLQEMGF------------RVDPMATI---- 1031
Query: 1086 XXXXXXXXXXXXXXXXXXXXXXXVVNGPEEKF----GNYDYLLGMKIWALTKERYEKLMK 1141
++N + ++ NY YLL M + LT + ++L +
Sbjct: 1032 ---------------AKNSKKVNLINYEDFQYLNFQANYGYLLEMPVSRLTSDEMKRLEE 1076
Query: 1142 QMQEKQTELERLLKLSAKDLWEIDLDDFVE 1171
+ ++TELE K +W +LD E
Sbjct: 1077 RKSRRRTELEAAESADWKSVWRSELDKLAE 1106
>CE07645 [B] KOG0355 DNA topoisomerase type II
Length = 816
Score = 541 bits (1394), Expect = e-153
Identities = 296/754 (39%), Positives = 442/754 (58%), Gaps = 35/754 (4%)
Query: 417 KKTDGSRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCF 476
+K + +++ PKLEDAN AGTK +CTL+LTEGD RD YG F
Sbjct: 36 QKCPKRKTSKLKGIPKLEDANDAGTKNSQQCTLILTEGDSAKTLAVSGLSVVGRDKYGVF 95
Query: 477 PLRGKMLNVREATPDQISKNAEIQAIKKIMGLQHKKRYE---DTTTLRYGHIMIMTDQDH 533
P R K+LNV + +QI+ +AE+ AI KI+GLQ+ K+YE D TLRYG ++IM + D
Sbjct: 96 PFRRKLLNVCDLNVNQIADSAEVNAIIKILGLQYTKKYETEDDFKTLRYGKLLIMANHDS 155
Query: 534 DGSHIKGLIINFLESSFPGLLD---IPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEK 590
DGS KGL++NF +P L + F+ KE +SFY++P+Y +
Sbjct: 156 DGSQFKGLLLNFFHRFWPALFKRDFVEDFITPIAKATEG-------KEEVSFYSLPEYSE 208
Query: 591 WREEESHKYTWKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKK 650
WR + ++ KYY GLGT T +EA++ FS + +H +F DD + +++AFSKKK
Sbjct: 209 WRMNTDNWKSYTIKYYNGLGTLTSKEAKKCFSDMVRHRIRFKYNGADDDKAVNMAFSKKK 268
Query: 651 ADDRKEWL-KLYEPGT-----------VLDPKLTEIPISDFINKELILFSLADNIRSIPS 698
+ R ++L KL + + + + + + DF N E++ + N+ SIP
Sbjct: 269 IEARTDYLMKLMQDKNQRKQQGLAEECLYNKETRFVTLKDFFNYEIVC---SWNLHSIPC 325
Query: 699 VLDGLKPGQRKVIYACFKRNLKSEIKVAQLGGYVSEHTGYHHGEQSLYQTIVGLAQDFVG 758
++DGLKPGQRKV++ACFKR K E+KVAQL G V+E + YHHGEQSL TIV LAQD+VG
Sbjct: 326 LVDGLKPGQRKVLFACFKRANKREVKVAQLAGAVAEISAYHHGEQSLMGTIVNLAQDYVG 385
Query: 759 SNNIYLLKPNGAFGTRATGGKDSAAPRYIFTELNKLTRKIFNTLDDPLLNYIQDDEQTVE 818
S+NI LL P G FGTR GGKDSA+ R IF +L+++TR +F DD +L ++ ++ Q +E
Sbjct: 386 SHNINLLLPIGQFGTRLQGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYEENQRIE 445
Query: 819 PEWYLPVIPMVLVNGTEGIGTGWSTNIPPFNPMDIVNNVKRLMKGEEMEQMAPWYRGWQG 878
PEWY P+IPMVLVNG +G GTGWSTNIP +NP ++V N+KRL+ GE + +APWY+ ++G
Sbjct: 446 PEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEPQKALAPWYKNFRG 505
Query: 879 SLEKIDPQKYRTYGRIEQIDENTLEITELPPKTWTSVIKEHLLLGL-SGNDKVKPWIKDI 937
+ +IDP ++ YG + +D+NT+EITELP K WT KE +L GL +DK P I D
Sbjct: 506 KIIQIDPSRFACYGEVSVLDDNTIEITELPIKQWTQDYKEKVLEGLMESSDKKSPVIVDY 565
Query: 938 QEQH-GATIKFIITLTSDEM-EKTRKIGFYERFKLVSTVSLSNMVAFDPQGKIKKYDDVR 995
+E H T+KF++ L+ ++ E R ++ FKL + ++ + MV FD G ++ Y
Sbjct: 566 KEYHTDTTVKFVVKLSPGKLRELERGQDLHQVFKLQAVINTTCMVLFDAAGWLRTYTSPE 625
Query: 996 DILSDFYYTRLTYYQKRKDYIGERLKWEVEKLSYQVKFIMMIVEKKLSVSNKPRPVLFEE 1055
I +FY +R Y +RK+Y+ L+ + ++L+ Q +FI+ + K+ + NK + + +
Sbjct: 626 AITQEFYDSRQEKYVQRKEYLLGVLQAQSKRLTNQARFILATINNKIVLENKKKTAIVDV 685
Query: 1056 LMSLGFPRINKEGKPTYGKVEEQAQIXXXXXXXXXXXXXXXXXXXXXXXXXXXVVNGPEE 1115
L+ + F + K++E + V E
Sbjct: 686 LIKMKFDADPVKKWKEDQKLKELRESGEIELDEDDLAAVAVEEGEDISSAAKAV----ET 741
Query: 1116 KFGNYDYLLGMKIWALTKERYEKLMKQMQEKQTE 1149
K +YDYL+G+ + L++E KL+K+ +EK E
Sbjct: 742 KLSDYDYLVGLALIKLSEEEKNKLIKESEEKMAE 775
>CE17740 [B] KOG0355 DNA topoisomerase type II
Length = 654
Score = 512 bits (1319), Expect = e-144
Identities = 275/626 (43%), Positives = 390/626 (61%), Gaps = 35/626 (5%)
Query: 2 TQSKTVSERYQKISQLEHILKRPDTYIGSVEVQESQ-QWIHDETTDCMIEKTVNIVPGLF 60
++ + + YQK SQLEHIL RPD+YIGS+E E + W+++ + ++ ++ VPGLF
Sbjct: 56 SKQMAIVDIYQKKSQLEHILLRPDSYIGSIEHTEKKPMWVYNMEDSKLEQRDISYVPGLF 115
Query: 61 KIFDEILVNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIF 120
KI+DEILVNAADNK RD M I V IN+ +N I V N+GKGIPV H E +++PELIF
Sbjct: 116 KIYDEILVNAADNKQRDRKMNTIRVTINKAKNEISVYNNGKGIPVTQHKVEKVFVPELIF 175
Query: 121 GHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCH 180
G LLTSSN+ ++K + GGRNGYGAKLCNIFST+F ET+ + Q W NNM+
Sbjct: 176 GSLLTSSNFVGNQKAMIGGRNGYGAKLCNIFSTKFTCETSSRVYKSAFKQTWINNMTRDE 235
Query: 181 PPKITSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKA 240
P I +TK+ F PDL +F M +LDDDI +M RR YD+ + + V+V LNG+
Sbjct: 236 EPTIVP-STDEDFTKITFSPDLAKFKMKELDDDICHLMARRAYDVAATCKGVDVILNGEM 294
Query: 241 LKIRNFKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVS 300
+ ++ F++YV++Y + + EP++ +YE+I +RW+VA A+S
Sbjct: 295 ISVKGFEDYVKMYTSQI-----------TFEGEPLK-------TVYEQIGNRWQVALALS 336
Query: 301 ENSFQQISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQ-KKTIKPFQIKNNMFIFINC 359
+ FQQISF N+++TT GG HV++V DQ+I ++ +K++ K + PF I+N++++F+NC
Sbjct: 337 DVGFQQISFANNVSTTKGGRHVDHVVDQMIARLKGSIKQELSKDVDPFMIENHLWVFVNC 396
Query: 360 LIENPAFTSQTKEQLTTRVKDFGSKCEVPSEFINKIMKTDLATKIFEIADENAHKQLKKT 419
LIE P F SQTKE +T R FGS C + +F ++ L +I + + L +
Sbjct: 397 LIEWPTFDSQTKEMMTLRHDRFGSTCALSKKFCKTALQIGLIRQISREIGVDIRENLVQ- 455
Query: 420 DGSRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGDXXXXXXXXXXXXXXRDYYGCFPLR 479
S + I PKLEDA AGTK +CTL++TEGD RD +G FPLR
Sbjct: 456 KASESSPIKCIPKLEDAKEAGTKTSERCTLIVTEGDSAKTLAISGLSVVGRDKFGVFPLR 515
Query: 480 GKMLNVREATPDQISKNAEIQAIKKIMGLQHKKRYE---DTTTLRYGHIMIMTDQDHDGS 536
GK+LNVR+A+ QI++NAE+ A+ KI+GLQ +YE + TLRYG +MIM DQD DGS
Sbjct: 516 GKLLNVRDASVKQIAENAEVNAMIKILGLQRDLKYEFDDEFRTLRYGKLMIMADQDQDGS 575
Query: 537 HIKGLIINFLESSFPGLLD---IPGFLXXXXXXXXXXXXSRPKKETISFYNMPDYEKWRE 593
HIKGLII+FL +P L+ + F+ KE +SFY++P+Y +WR
Sbjct: 576 HIKGLIISFLHHFWPSLIQRNFVEEFITPIVKATKG-------KEEVSFYSLPEYSEWRT 628
Query: 594 EESHKYTWKQKYYKGLGTSTQQEARE 619
+ ++K KYYKGLGTST +EA+E
Sbjct: 629 NTDNWKSYKIKYYKGLGTSTAKEAKE 654
>CE24315 [B] KOG0355 DNA topoisomerase type II
Length = 644
Score = 256 bits (653), Expect = 2e-67
Identities = 128/283 (45%), Positives = 185/283 (65%), Gaps = 35/283 (12%)
Query: 624 LDKHLKKFHALQGDDSQLIDLAFSKKKADDRKEWLKLY--------EPGT----VLDPKL 671
+D+H +F G D+ ID+ FSKKK+++RK+WL + + G + D
Sbjct: 1 MDRHRIRFK-YNGADA--IDMVFSKKKSEERKDWLSKWMREKKDRKQQGLAEEYLYDKDT 57
Query: 672 TEIPISDFINKELILFSLADNIRSIPSVLDGLKPGQRKVIYACFKRNLKSEIKVAQLGGY 731
+ DF+N+EL+LFS DN RSIP ++DG KPGQRKV++ACFKR+ K +KVAQL G
Sbjct: 58 RFVTFKDFVNRELVLFSNLDNERSIPCLVDGFKPGQRKVLFACFKRSDKHGVKVAQLAGG 117
Query: 732 VSEHTGYHHGEQSLYQTIVGLAQDFVGSNNIYLLKPNGAFGTRATGGKDSAAPRYIFTEL 791
V++ + YHHGEQSL TIV LAQD+ GGKDSA+ +YIFT+L
Sbjct: 118 VADMSAYHHGEQSLMTTIVHLAQDY--------------------GGKDSASAQYIFTQL 157
Query: 792 NKLTRKIFNTLDDPLLNYIQDDEQTVEPEWYLPVIPMVLVNGTEGIGTGWSTNIPPFNPM 851
+ +TR +F + DD +L ++ ++ Q +EPEWY P+ PMVLVNG +GI TGW TNIP +NP
Sbjct: 158 SPVTRTLFPSHDDNVLRFLYEENQRIEPEWYCPISPMVLVNGAQGIDTGWRTNIPNYNPR 217
Query: 852 DIVNNVKRLMKGEEMEQMAPWYRGWQGSLEKIDPQKYRTYGRI 894
++V N+KRL+ GE + +APWY+ ++G + +IDP+++ YG +
Sbjct: 218 ELVKNIKRLIAGEPQKALAPWYKNFRGKIIQIDPRRFACYGEV 260
>CE18656 [B] KOG0355 DNA topoisomerase type II
Length = 263
Score = 206 bits (523), Expect = 3e-52
Identities = 114/241 (47%), Positives = 143/241 (59%), Gaps = 31/241 (12%)
Query: 7 VSERYQKISQLEHILKRPDTYIGSVEVQESQ-QWIHDETTDCMIEKTVNIVPGLFKIFDE 65
V + YQK S LEHIL RPD+YIGS+E E + W++
Sbjct: 51 VEDAYQKKSHLEHILLRPDSYIGSIEHNEKKPMWVY------------------------ 86
Query: 66 ILVNAADNKV--RDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHL 123
N D+K+ RDP M I + IN E+N I V N+GKGIPV H E +Y+PELIFG L
Sbjct: 87 ---NMKDSKLEQRDPKMNTIKITINTEKNEISVYNNGKGIPVTQHKVEKVYVPELIFGAL 143
Query: 124 LTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMSTCHPPK 183
LTS NY+DDEKK+TGGRNGYGAKLCN+FST+ LET+ + Q W NNM+ P
Sbjct: 144 LTSYNYNDDEKKLTGGRNGYGAKLCNLFSTKVTLETSSVDYKSAFKQTWINNMTRDEEPT 203
Query: 184 ITSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKALKI 243
I +TK+ F PDL +F +LDDDI +M RR YD+ GS + V VSLNGK + I
Sbjct: 204 IVP-STDEDFTKITFSPDLAKFKTKELDDDICHLMARRAYDVAGSCKGVAVSLNGKRIPI 262
Query: 244 R 244
+
Sbjct: 263 K 263
>CE01933 [B] KOG0355 DNA topoisomerase type II
Length = 270
Score = 132 bits (331), Expect = 5e-30
Identities = 66/122 (54%), Positives = 83/122 (67%), Gaps = 1/122 (0%)
Query: 91 ENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNI 150
+N I V N+GKGIPV H E +++PELIFG LLTSSNY++DEKKV GGRNGY AKLCNI
Sbjct: 18 KNEISVYNNGKGIPVTQHKVEKVFVPELIFGTLLTSSNYNNDEKKVAGGRNGYEAKLCNI 77
Query: 151 FSTEFILETADPSRGHKYIQNWENNMSTCHPPKITSYKKGPSYTKVIFKPDLQRFGMDKL 210
FS +F +ET+ + Q W NNM+ PKI + +TK+ F PDL +F M +L
Sbjct: 78 FSNKFTMETSFRDYKSAFKQTWINNMTRDEEPKIVESTE-KDFTKITFSPDLSKFKMKEL 136
Query: 211 DD 212
DD
Sbjct: 137 DD 138
Score = 59.7 bits (143), Expect = 3e-08
Identities = 30/54 (55%), Positives = 37/54 (67%), Gaps = 4/54 (7%)
Query: 299 VSENSFQQISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQ----KKTIKPFQ 348
+SE QQ+SFVNSIATT GG HV+YV DQ++ K D +KK+ IKPFQ
Sbjct: 155 LSEKGSQQVSFVNSIATTKGGRHVDYVADQMVTKFIDSIKKKLTKTSTNIKPFQ 208
>At3g10270 [B] KOG0355 DNA topoisomerase type II
Length = 657
Score = 105 bits (263), Expect = 4e-22
Identities = 133/570 (23%), Positives = 232/570 (40%), Gaps = 83/570 (14%)
Query: 8 SERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIFDEIL 67
SE Q + L+ + KRP YIGS + GL + EIL
Sbjct: 15 SEHIQVLEGLDPVRKRPGMYIGSTGSR-----------------------GLHHLVYEIL 51
Query: 68 VNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLLTSS 127
NA D + + KIDVV++ +++ + + ++G+GIP ++H G E + L
Sbjct: 52 DNAID-EAQAGFASKIDVVLHSDDS-VSISDNGRGIPTDLHPATGKSSLETVLTVLHAGG 109
Query: 128 NYDDDEK--KVTGGRNGYGAKLCNIFST--EFILETADPSRGHKYIQNWENNMSTCH--P 181
+ V+GG +G G + N S E I+ KY + TCH P
Sbjct: 110 KFGGKSSGYSVSGGLHGVGLSVVNALSEALEVIVRRDGMEFQQKYSRGKPVTTLTCHVLP 169
Query: 182 PKITSYKKGPSYTKVIFKPDLQRFGMDKLDDDIVGVMRRRVYDINGSVRDVNVSLNGKA- 240
P+ +G T + F PD + F + ++ I G +R++ LN K
Sbjct: 170 PE----SRGTQGTCIRFWPDKEGFAL------FTTAIQFDHNTIAGRIREL-AFLNPKVT 218
Query: 241 LKIRNFKNYVELYLKSLEKIKLNRLRESSTPDEPMQEPTKIPTILYERINDRWEVAFAVS 300
+ ++ + E + S E L E + ++P L++ + R E+ +
Sbjct: 219 ISLKKEDDDPERDVYS-EYFYAGGLTEYVSWLNTDKKP------LHDVLGFRKEINGSTV 271
Query: 301 ENSFQ---------QISFVNSIATTSGGTHVNYVTDQIIKKVSDRLKKQKK------TIK 345
+ S Q + + NSI T GGTH+ V + + ++ KK K ++
Sbjct: 272 DVSLQWCSDAYSDTMLGYANSIRTIDGGTHIEGVKASLTRTLNSLAKKLKVIKEKDISLS 331
Query: 346 PFQIKNNMFIFINCLIENPAFTSQTKEQLTT---------RVKDFGSK-CEVPSEFINKI 395
++ + ++ + NP F QTK +L V+++ ++ E+ + + I
Sbjct: 332 GEHVREGLTCIVSVKVPNPEFEGQTKTRLGNPEVRKIVDQSVQEYLTEYLELHPDVLESI 391
Query: 396 MKTDLATKIFEIADENAHKQLKKTDGSRKNRITEYPKLEDANMAGTKEGYKCTLVLTEGD 455
+ L +A + A + ++ + + + KL D + E + + EGD
Sbjct: 392 ISKSLNAYKAALAAKRARELVRSKSVLKSSSLPG--KLADCSSTDPAES---EIFIVEGD 446
Query: 456 XXXXXXXXXXXXXXRDYYGCFPLRGKMLNVREATPDQISKNAEIQAIKKIMGLQHKKRYE 515
R + PLRGK+LN+ + KN EIQ + +GL K
Sbjct: 447 SAGGSAKQGRD---RRFQAILPLRGKILNIERKDEAAMYKNEEIQNLILGLGLGVKGEDF 503
Query: 516 DTTTLRYGHIMIMTDQDHDGSHIKGLIINF 545
+ LRY I+I+TD D DG+HI+ L++ F
Sbjct: 504 NKENLRYHKIIILTDADVDGAHIRTLLLTF 533
>At5g04130 [B] KOG0355 DNA topoisomerase type II
Length = 760
Score = 100 bits (248), Expect = 2e-20
Identities = 137/584 (23%), Positives = 235/584 (39%), Gaps = 84/584 (14%)
Query: 8 SERYQKISQLEHILKRPDTYIGSVEVQESQQWIHDETTDCMIEKTVNIVPGLFKIFDEIL 67
SE+ Q + L+ + KRP YIGS + GL + EIL
Sbjct: 91 SEQIQVLEGLDPVRKRPGMYIGSTGSR-----------------------GLHHLVYEIL 127
Query: 68 VNAADNKVRDPSMKKIDVVINQEENTIEVKNDGKGIPVEIHDKEGIYIPELIFGHLLTSS 127
NA D + + K+DVV++ + ++ V ++G+GIP ++H E + L
Sbjct: 128 DNAID-EAQAGYASKVDVVLHAD-GSVSVVDNGRGIPTDLHPATKKSSLETVLTVLHAGG 185
Query: 128 NYDDDEK--KVTGGRNGYGAKLCNIFSTEFILETADPSRGHKYIQNWENNMS----TCHP 181
+ V+GG +G G + N S LE + G ++ QN+ TC
Sbjct: 186 KFGGTSSGYSVSGGLHGVGLSVVNALSEA--LEVSVWRDGMEHKQNYSRGKPITTLTCRV 243
Query: 182 PKITSYKKGPSYTKVIFKPDLQRFGM---------DKLDDDIVGVMRRRVYDI-NGSVRD 231
+ S KG T + F PD + F KLD I + ++ + ++
Sbjct: 244 LPLES--KGTKGTSIRFWPDKEGFACFPLLTTLPKPKLDLMINFPLWNELFSVFTTAIEF 301
Query: 232 VNVSLNGKALKIRNFKNYVELYLKSL----EKIKLNRLRESSTPDEPMQEPTKIPTILYE 287
+ ++ G+ ++ V + LK EK + + + E + +++
Sbjct: 302 DHNTIAGRIRELAFLNPKVTISLKKEDDDPEKTQYSEYSFAGGLTEYVSWLNTDKNPIHD 361
Query: 288 RINDRWEVAFAVSENSFQ---------QISFVNSIATTSGGTHVNYVTDQIIKKVSDRLK 338
+ R E+ A + + Q + + NSI T GGTH+ V + + ++ L
Sbjct: 362 VLGFRREINGATVDVALQWCSDAYSDTMLGYANSIRTIDGGTHIEGVKASLTRTLNT-LA 420
Query: 339 KQKKTIKPFQI-------KNNMFIFINCLIENPAFTSQTKEQL----TTRVKDFGSKCEV 387
K+ KT+K I + + ++ + NP F QTK +L ++ D S E
Sbjct: 421 KKSKTVKEKDISLSGEHVREGLTCIVSVKVPNPEFEGQTKTRLGNPEVRKIVD-QSVQEY 479
Query: 388 PSEFINKIMKTDLATKIFEIADENAHKQLKKTDGSRKNRITEYPKLEDANMAGTKEGYKC 447
+EF+ + D+ I NA+K +R+ + L+ +++ G
Sbjct: 480 LTEFLE--LHPDILESIIS-KSLNAYKAALAAKRARE-LVRSKSVLKSSSLPGKLADCSS 535
Query: 448 T------LVLTEGDXXXXXXXXXXXXXXRDYYGCFPLRGKMLNVREATPDQISKNAEIQA 501
T + + EGD R + PLRGK+LN+ + KN EIQ
Sbjct: 536 TDPEVSEIFIVEGDSAGGSAKQGRD---RRFQAILPLRGKILNIERKDEAAMYKNEEIQN 592
Query: 502 IKKIMGLQHKKRYEDTTTLRYGHIMIMTDQDHDGSHIKGLIINF 545
+ +GL K LRY I+I+TD D DG+HI+ L++ F
Sbjct: 593 LILGLGLGVKGEDFKKENLRYHKIIILTDADVDGAHIRTLLLTF 636
>At3g10690 [B] KOG0355 DNA topoisomerase type II
Length = 917
Score = 79.3 bits (194), Expect = 4e-14
Identities = 69/232 (29%), Positives = 116/232 (49%), Gaps = 21/232 (9%)
Query: 694 RSIPSVLDGLKPGQRKVIYACFKRNLKSEIKVAQLGGYVSEHTG--YHHGEQSLYQTIVG 751
R++P V DGLKP R++++A + + S+ + V E G + HG+ ++Y ++V
Sbjct: 125 RALPDVRDGLKPVHRRILFAMHELGMSSKKPYKKCARVVGEVLGKFHPHGDTAVYDSLVR 184
Query: 752 LAQDFVGSNNIYLLKPNGAFGTRATGGKDSAAPRYIFTELNKLTRKIF-NTLDDPLLNYI 810
+AQ F S L++ +G FG+ AA RY L+ L + + LD ++++
Sbjct: 185 MAQSF--SLRCPLIQGHGNFGS--IDADPPAAMRYTECRLDPLAEAVLLSDLDQDTVDFV 240
Query: 811 QDDEQTVEPEWYLPV-IPMVLVNGTEGIGTGWSTNIPPFNPMDIVNNVKRLMKGEE---- 865
+ + + + LP +P +L+NG GI G +TNIPP N ++V+ + L+ E
Sbjct: 241 ANFDNSQKEPAVLPARLPALLLNGASGIAVGMATNIPPHNLGELVDVLCALIHNPEATLQ 300
Query: 866 --MEQM-APWYRGW---QGSLEKIDPQKYRTYGRIEQIDENTLEITELPPKT 911
+E M AP + G+L +D YRT GR + E+ L PKT
Sbjct: 301 ELLEYMPAPDFPTGGIIMGNLGVLD--AYRT-GRGRVVVRGKAEVELLDPKT 349
>At2g13720 [B] KOG0355 DNA topoisomerase type II
Length = 223
Score = 55.1 bits (131), Expect = 8e-07
Identities = 32/102 (31%), Positives = 57/102 (55%), Gaps = 3/102 (2%)
Query: 593 EEESHKYTWKQKYYKGLGTSTQQEAREYFSGLDKHLKKFHALQGDDSQLIDLAFSKKKAD 652
++ ++ W K+YKG+ +E + S +D++ + F +G ++ L + AF + D
Sbjct: 84 KDRNYLNRWTIKFYKGVWVQVMRE-KNVLSNVDQNKRFFIWDEGSEAAL-ENAFGTSE-D 140
Query: 653 DRKEWLKLYEPGTVLDPKLTEIPISDFINKELILFSLADNIR 694
+K+W++ Y PGT LD K +I SDF+ K+L L+ N R
Sbjct: 141 KQKKWIEKYVPGTFLDSKKQQIMYSDFVTKKLKLYFTTSNQR 182
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.134 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,669,166
Number of Sequences: 60738
Number of extensions: 3525893
Number of successful extensions: 8514
Number of sequences better than 1.0e-05: 18
Number of HSP's better than 0.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 8377
Number of HSP's gapped (non-prelim): 36
length of query: 1435
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1316
effective length of database: 23,161,394
effective search space: 30480394504
effective search space used: 30480394504
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)