ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3530 good O KOG3158 Posttranslational modification, protein turnover, chaperones HSP90 co-chaperone p23
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3530 1244547 1243996 -184
(184 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL117w [O] KOG3158 HSP90 co-chaperone p23 154 9e-38
SPAC9E9.13 [O] KOG3158 HSP90 co-chaperone p23 131 6e-31
CE01436 [O] KOG3158 HSP90 co-chaperone p23 77 1e-14
At4g02450 [O] KOG3158 HSP90 co-chaperone p23 71 7e-13
Hs7705459 [R] KOG3187 Protein tyrosine phosphatase-like protein ... 68 6e-12
Hs20549562 [R] KOG3187 Protein tyrosine phosphatase-like protein... 68 6e-12
7299227 [O] KOG3158 HSP90 co-chaperone p23 65 5e-11
HsM5729964 [O] KOG3158 HSP90 co-chaperone p23 63 2e-10
7298067 [R] KOG3187 Protein tyrosine phosphatase-like protein PT... 61 8e-10
Hs18599655 [O] KOG3158 HSP90 co-chaperone p23 53 2e-07
Hs13376886_1 [O] KOG3158 HSP90 co-chaperone p23 49 4e-06
>YKL117w [O] KOG3158 HSP90 co-chaperone p23
Length = 216
Score = 154 bits (388), Expect = 9e-38
Identities = 84/159 (52%), Positives = 103/159 (63%), Gaps = 5/159 (3%)
Query: 3 VHTPEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGIKYH 62
V P+V WAQRSS +D +N + IT++I DC P++ + + +E A SK H D +H
Sbjct: 5 VINPQVAWAQRSSTTDPERNYVLITVSIADCDAPELTIKPSYIELKAQSKPHVGDENVHH 64
Query: 63 --LHIDFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKW 120
LHID YK I E + +VANG++YFL L KKDL EYWPRLTKEK+KY YIKTDFDKW
Sbjct: 65 YQLHIDLYKEIIPEKTMHKVANGQHYFLKLYKKDLESEYWPRLTKEKVKYPYIKTDFDKW 124
Query: 121 VDEDEQEENVAADNDLMS--QFGQ-MGGAGFPGMEQGFN 156
VDEDEQ+E A ND F Q MGGAG G G +
Sbjct: 125 VDEDEQDEVEAEGNDAAQGMDFSQMMGGAGGAGGAGGMD 163
>SPAC9E9.13 [O] KOG3158 HSP90 co-chaperone p23
Length = 186
Score = 131 bits (329), Expect = 6e-31
Identities = 76/166 (45%), Positives = 100/166 (59%), Gaps = 24/166 (14%)
Query: 1 MSVHT--PEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDG 58
MS++T PEVLWAQRS++ D KN +++T+ IPD +PK+ LT L + S ++
Sbjct: 1 MSLNTQIPEVLWAQRSNKDDAEKNVIYLTVLIPDAVDPKINLTPEKLVIDSKSGANAH-- 58
Query: 59 IKYHLHIDFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFD 118
Y + IDF+K ID E S+ V GR F VL KK+L E+WPRLTKEKL+ H+++TDFD
Sbjct: 59 --YAVQIDFFKDIDVEKSKYSVT-GRYIFFVLYKKELQEEFWPRLTKEKLRLHWLRTDFD 115
Query: 119 KWVDEDEQEE-------NVAADNDL----------MSQFGQMGGAG 147
+WVDEDEQE DL SQFG +GGAG
Sbjct: 116 RWVDEDEQEAQPEVSPFGAGGMPDLSALGGMGGMDFSQFGNLGGAG 161
>CE01436 [O] KOG3158 HSP90 co-chaperone p23
Length = 175
Score = 77.0 bits (188), Expect = 1e-14
Identities = 52/160 (32%), Positives = 76/160 (47%), Gaps = 27/160 (16%)
Query: 6 PEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGIKYHLHI 65
P VLWAQR S +++TI + + +++ N L F SK KY +
Sbjct: 5 PTVLWAQRESL-------VYLTIEVDEAKIEELKGEGNKLHFQGSSKTD-----KYEATL 52
Query: 66 DFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKWVDEDE 125
+F+ ID + + ++ R + ++KK +WPRL + K K H++K DF KW DEDE
Sbjct: 53 EFFDEIDPASVKHTGSSTRVVEITVQKKTPA--WWPRLLQNKGKVHWLKVDFGKWKDEDE 110
Query: 126 QEENVAAD-------------NDLMSQFGQMGGAGFPGME 152
+E A N MSQ G GGA F G+E
Sbjct: 111 DDEAEDAGAGIGGGMANGFDLNQYMSQMGGAGGADFGGLE 150
>At4g02450 [O] KOG3158 HSP90 co-chaperone p23
Length = 262
Score = 71.2 bits (173), Expect = 7e-13
Identities = 49/151 (32%), Positives = 78/151 (51%), Gaps = 16/151 (10%)
Query: 3 VHTPEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELT-ENSLEFSALSKYHSKDGIKY 61
+ PEV WA+ T +F+T+ + D + K+ L E +FSA K ++ + Y
Sbjct: 6 IRHPEVKWAE-------TTEKIFLTVVLADTKDTKVNLDPEGVFDFSA--KVGPENHV-Y 55
Query: 62 HLHIDFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKWV 121
L ++ ++ E S+ + R+ F ++ K + E W +L + K HY+K D+DKWV
Sbjct: 56 ELKLELADKVNVEESKINIGE-RSIFCIIEKAEP--ERWNKLLRVKKPPHYVKVDWDKWV 112
Query: 122 DEDEQEENVAADNDL--MSQFGQMGGAGFPG 150
DED++ AAD D+ M G MGG G G
Sbjct: 113 DEDDEGSAGAADMDMAGMEGMGGMGGMGGMG 143
>Hs7705459 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 373
Score = 68.2 bits (165), Expect = 6e-12
Identities = 43/135 (31%), Positives = 68/135 (49%), Gaps = 16/135 (11%)
Query: 3 VHTPEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGI-KY 61
V TP V WAQR E L++ + + D NP + +TEN L F A D + ++
Sbjct: 5 VLTPHVYWAQRHRE-------LYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEF 57
Query: 62 HLH-IDFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKW 120
HL +D KP QR N + ++KK ++W RLTK++ + ++ DFD+W
Sbjct: 58 HLEFLDLVKPEPVYKLTQRQVN-----ITVQKKVS--QWWERLTKQEKRPLFLAPDFDRW 110
Query: 121 VDEDEQEENVAADND 135
+DE + E + A +
Sbjct: 111 LDESDAEMELRAKEE 125
>Hs20549562 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 362
Score = 68.2 bits (165), Expect = 6e-12
Identities = 43/135 (31%), Positives = 68/135 (49%), Gaps = 16/135 (11%)
Query: 3 VHTPEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGI-KY 61
V TP V WAQR E L++ + + D NP + +TEN L F A D + ++
Sbjct: 5 VLTPHVYWAQRHRE-------LYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEF 57
Query: 62 HLH-IDFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKW 120
HL +D KP QR N + ++KK ++W RLTK++ + ++ DFD+W
Sbjct: 58 HLEFLDLVKPEPVYKLTQRQVN-----ITVQKKVS--QWWERLTKQEKRPLFLAPDFDRW 110
Query: 121 VDEDEQEENVAADND 135
+DE + E + A +
Sbjct: 111 LDESDAEMELRAKEE 125
>7299227 [O] KOG3158 HSP90 co-chaperone p23
Length = 184
Score = 65.1 bits (157), Expect = 5e-11
Identities = 44/151 (29%), Positives = 66/151 (43%), Gaps = 12/151 (7%)
Query: 6 PEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGIKYHLHI 65
P V WAQR N+L I +C + + ++TE + F ++ KY + +
Sbjct: 10 PPVSWAQR--------NDLIYVIIDVECKDIEHKVTEKTFTFKGVNVLDPSK--KYEVTL 59
Query: 66 DFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKWVDEDE 125
+F +D E + GR + KK G YW LT +K K H++K +F KW DE +
Sbjct: 60 NFLHEVDPEKVTSKNI-GRCLEFTIPKKAAG-PYWSSLTTDKTKLHFLKANFAKWRDESD 117
Query: 126 QEENVAADNDLMSQFGQMGGAGFPGMEQGFN 156
EE DN + F G + FN
Sbjct: 118 DEEGDQKDNSMFGNFLNSPGGDWNNKFDDFN 148
>HsM5729964 [O] KOG3158 HSP90 co-chaperone p23
Length = 160
Score = 63.2 bits (152), Expect = 2e-10
Identities = 38/128 (29%), Positives = 66/128 (50%), Gaps = 6/128 (4%)
Query: 19 DTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGIKYHLHIDFYKPIDTENSEQ 78
D ++ +FI + D + + ++ L FS L D K+ ID + ID +S+
Sbjct: 10 DRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLG---GSDNFKHLNEIDLFHCIDPNDSKH 66
Query: 79 RVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKWVD-EDEQEENVAADNDLM 137
+ + R+ LRK + G + WPRLTKE+ K +++ DF+ W D ED+ +E+++ +
Sbjct: 67 KRTD-RSILCCLRKGESG-QSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFS 124
Query: 138 SQFGQMGG 145
MGG
Sbjct: 125 EMMNNMGG 132
>7298067 [R] KOG3187 Protein tyrosine phosphatase-like protein PTPLA
(contains Pro instead of catalytic Arg)
Length = 371
Score = 61.2 bits (147), Expect = 8e-10
Identities = 39/124 (31%), Positives = 62/124 (49%), Gaps = 13/124 (10%)
Query: 5 TPEVLWAQRSSESDDTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGIK-YHL 63
+P V W+Q TK L + +++ D + + S+ FSA H G+ Y
Sbjct: 5 SPFVYWSQ-------TKQTLLLKVDLKDAKGAIADFSPVSVNFSANG--HGARGVNAYKF 55
Query: 64 HIDFYKPIDTENSEQRVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKWVDE 123
+ FY ID EN+ V++ + + L+ + L E+WPRL K H++K DFD+W E
Sbjct: 56 ELHFYALIDDENATFVVSDNK---IELQIRKLEPEWWPRLVATPQKPHWLKIDFDRWRTE 112
Query: 124 DEQE 127
D+ E
Sbjct: 113 DDVE 116
>Hs18599655 [O] KOG3158 HSP90 co-chaperone p23
Length = 160
Score = 53.1 bits (126), Expect = 2e-07
Identities = 36/128 (28%), Positives = 62/128 (48%), Gaps = 6/128 (4%)
Query: 19 DTKNNLFITINIPDCTNPKMELTENSLEFSALSKYHSKDGIKYHLHIDFYKPIDTENSEQ 78
D ++ +F + D + + ++ L FS L D K+ I + ID +S+
Sbjct: 10 DRRDCVFTESCVEDNKDVNVNFEKSKLTFSCLG---GSDNFKHLNEIGLFYSIDPNDSKH 66
Query: 79 RVANGRNYFLVLRKKDLGLEYWPRLTKEKLKYHYIKTDFDKWVD-EDEQEENVAADNDLM 137
+ + R+ LRK + G + WPRLTKE+ K +++ DF+ W D ED +E+ + +
Sbjct: 67 KRTD-RSILCCLRKGESG-QSWPRLTKERAKLNWLSMDFNHWKDWEDGSDEDRSNFDRFS 124
Query: 138 SQFGQMGG 145
MGG
Sbjct: 125 EMMNNMGG 132
>Hs13376886_1 [O] KOG3158 HSP90 co-chaperone p23
Length = 97
Score = 48.9 bits (115), Expect = 4e-06
Identities = 28/99 (28%), Positives = 55/99 (55%), Gaps = 6/99 (6%)
Query: 30 IPDCTNPKMELTENSLEFSALSKYHSKDGIKYHLHIDFYKPIDTENSEQRVANGRNYFLV 89
+ D T+ + + ++ + FS + DG++ + I+FY +++++S+ + + R+
Sbjct: 5 VEDSTDVHVLIEDHRIVFSC----KNADGVELYNEIEFYAKVNSKDSQDK-RSSRSITCF 59
Query: 90 LRKKDLGLEYWPRLTKEKLKYHYIKTDFDKWVDEDEQEE 128
+RK + WPRLTKE +K ++ DFD W D + EE
Sbjct: 60 VRKWKEKVA-WPRLTKEDIKPVWLSVDFDNWRDWEGDEE 97
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,310,165
Number of Sequences: 60738
Number of extensions: 499431
Number of successful extensions: 1124
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1108
Number of HSP's gapped (non-prelim): 12
length of query: 184
length of database: 30,389,216
effective HSP length: 100
effective length of query: 84
effective length of database: 24,315,416
effective search space: 2042494944
effective search space used: 2042494944
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)