ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3568 good E KOG1383 Amino acid transport and metabolism Glutamate decarboxylase/sphingosine phosphate lyase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3568 1256193 1257893 567
(567 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YMR250w [E] KOG1383 Glutamate decarboxylase/sphingosine phosphat... 691 0.0
At5g17330 [E] KOG1383 Glutamate decarboxylase/sphingosine phosph... 306 7e-83
At2g02000 [E] KOG1383 Glutamate decarboxylase/sphingosine phosph... 298 1e-80
At1g65960 [E] KOG1383 Glutamate decarboxylase/sphingosine phosph... 297 3e-80
At3g17760 [E] KOG1383 Glutamate decarboxylase/sphingosine phosph... 296 4e-80
At2g02010 [E] KOG1383 Glutamate decarboxylase/sphingosine phosph... 296 6e-80
At3g17720 [E] KOG1383 Glutamate decarboxylase/sphingosine phosph... 106 1e-22
YDR294c [E] KOG1383 Glutamate decarboxylase/sphingosine phosphat... 94 7e-19
7302829 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphat... 91 4e-18
CE20348 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphat... 81 4e-15
CE06695 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphat... 80 6e-15
CE26034 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphat... 79 1e-14
At1g27980 [E] KOG1383 Glutamate decarboxylase/sphingosine phosph... 78 3e-14
Hs10190653 [E] KOG1383 Glutamate decarboxylase/sphingosine phosp... 69 1e-11
Hs20471012 [E] KOG1383 Glutamate decarboxylase/sphingosine phosp... 69 2e-11
>YMR250w [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 585
Score = 691 bits (1784), Expect = 0.0
Identities = 330/529 (62%), Positives = 415/529 (78%), Gaps = 9/529 (1%)
Query: 47 DKFAVPKKGLHSEHVYNLVKNELKLDGNPVLNLASFVNTFTDQFAQKLIDENLNKNLADN 106
+K++VPKKGL ++ Y L+ NEL LDGNP LNLASFVNTFT A+KLIDENL KNLADN
Sbjct: 58 NKYSVPKKGLPADLSYQLIHNELTLDGNPHLNLASFVNTFTTDQARKLIDENLTKNLADN 117
Query: 107 DEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCATTGSSEAIMLGGLAMKRQWEKKMRAA 166
DEYPQLI + +RCISMLA+LW ++ D + P+GCATTGSSEAIMLGGLAMK++WE +M+ A
Sbjct: 118 DEYPQLIELTQRCISMLAQLWHANPDEE-PIGCATTGSSEAIMLGGLAMKKRWEHRMKNA 176
Query: 167 NKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIGIF 226
K KPNIIMSSACQVALEKF RYF+VECRLVPV + L+P LWDYV+ENTIG F
Sbjct: 177 GKDASKPNIIMSSACQVALEKFTRYFEVECRLVPVSHRSHHMLDPESLWDYVDENTIGCF 236
Query: 227 VILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQMES 286
VILGTTYTGHLEN+E+VA+VL IEA+HPDWSN DIPIH DGASGGFI+PF F + M++
Sbjct: 237 VILGTTYTGHLENVEKVADVLSQIEAKHPDWSNTDIPIHADGASGGFIIPFGFEKEHMKA 296
Query: 287 YGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEETFN 346
YG+ RWGFNHPRVVS+NTSGHKFGLTTPGLGW++W+++ L ELRFKLKYLGG+EETF
Sbjct: 297 YGMERWGFNHPRVVSMNTSGHKFGLTTPGLGWVLWRDESLLADELRFKLKYLGGVEETFG 356
Query: 347 LNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVARAFAWKLLQDPDMRDVFEVVSCLH 406
LNFSRPGFQV+HQY+N ++LG GY +F S+FVARAF+++LL + FE+VS +H
Sbjct: 357 LNFSRPGFQVVHQYFNFVSLGHSGYRTQFQNSLFVARAFSFELLNSSKLPGCFEIVSSIH 416
Query: 407 ENLDNSSIAESLDDYWKNPHDYKPGIPLCAFKLSEKFKSEHPEIPQSIISTLLRQKGWII 466
E+++N S +S+ DYW++P YKPG+PL AFKLS+KF E+PE+PQ+I+S+LLR +GWII
Sbjct: 417 ESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLSKKFHEEYPEVPQAILSSLLRGRGWII 476
Query: 467 PNYPLPESTDGSDKKEVLRVVFRIEMKLDMALLLVQDVFEVVQKLLKSYE----YLNIRT 522
PNYPLP++TDGSD+KEVLRVVFR EMKLD+A LL+ D+ ++ KL+ SYE ++ + +
Sbjct: 477 PNYPLPKATDGSDEKEVLRVVFRSEMKLDLAQLLIVDIESILTKLIHSYEKVCHHIELAS 536
Query: 523 ENDNHAVFKVLSTLSNADVSELEHELTDSQKEKEQHIK----KNYRGTC 567
E + + A S + T + EK+ +K +NYRGTC
Sbjct: 537 EQTPERKSSFIYEMLLALASPQDDIPTPDEIEKKNKLKETTTRNYRGTC 585
>At5g17330 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 502
Score = 306 bits (783), Expect = 7e-83
Identities = 185/472 (39%), Positives = 263/472 (55%), Gaps = 56/472 (11%)
Query: 44 TRIDKFAVPKKGLHSEHVYNLVKNELKLDGNPVLNLASFVNTFTDQFAQKLIDENLNKNL 103
T + +F +P+ + E Y ++ +EL LDGNP LNLASFV T+ + KLI ++NKN
Sbjct: 25 TSLPRFKMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPECDKLIMSSINKNY 84
Query: 104 ADNDEYPQLIHMNERCISMLAKLWQSDTDR-DTPLGCATTGSSEAIMLGGLAMKRQWEKK 162
D DEYP + RC++M+A L+ + + +T +G T GSSEAIML GLA KR+W+ K
Sbjct: 85 VDMDEYPVTTELQNRCVNMIAHLFNAPLEEAETAVGVGTVGSSEAIMLAGLAFKRKWQNK 144
Query: 163 MRAANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENT 222
+A K +KPNI+ + QV EKFARYF+VE + V + +E Y ++P + D V+ENT
Sbjct: 145 RKAEGKPVDKPNIVTGANVQVCWEKFARYFEVELKEVKL-SEGYYVMDPQQAVDMVDENT 203
Query: 223 IGIFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEA 282
I + ILG+T G E+++ + ++L + + W D PIHVD ASGGFI PF + E
Sbjct: 204 ICVAAILGSTLNGEFEDVKLLNDLLVE-KNKETGW---DTPIHVDAASGGFIAPFLYPEL 259
Query: 283 QMESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIE 342
+ W F P V SIN SGHK+GL G+GW++W+N E L EL F + YLG +
Sbjct: 260 E--------WDFRLPLVKSINVSGHKYGLVYAGIGWVIWRNKEDLPEELIFHINYLGADQ 311
Query: 343 ETFNLNFSRPGFQVIHQYYNLLTLGQQGY---YEKFNQSIFVARAFAWKLLQDPDMRDVF 399
TF LNFS+ QVI QYY L+ LG +GY E +++ V R + + + F
Sbjct: 312 PTFTLNFSKGSSQVIAQYYQLIRLGHEGYRNVMENCRENMIVLR-------EGLEKTERF 364
Query: 400 EVVSCLHENLDNSSIAESLDDYWKNPHDYKPGIPLCAFKLSEKFKSEHPEIPQSIISTLL 459
+VS G+PL AF L K S H E IS +L
Sbjct: 365 NIVS------------------------KDEGVPLVAFSL--KDSSCHTEFE---ISDML 395
Query: 460 RQKGWIIPNYPLPESTDGSDKKEVLRVVFRIEMKLDMALLLVQDVFEVVQKL 511
R+ GWI+P Y +P + + VLRVV R + +A LV D+ +V+++L
Sbjct: 396 RRYGWIVPAYTMPPN---AQHITVLRVVIREDFSRTLAERLVIDIEKVMREL 444
>At2g02000 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 500
Score = 298 bits (764), Expect = 1e-80
Identities = 181/467 (38%), Positives = 257/467 (54%), Gaps = 50/467 (10%)
Query: 46 IDKFAVPKKGLHSEHVYNLVKNELKLDGNPVLNLASFVNTFTDQFAQKLIDENLNKNLAD 105
I +F +PK + E Y ++ +ELK DGNP LNLASFV T+ + KL+ E++NKN +
Sbjct: 27 ISRFEIPKNSIPKEAAYQIINDELKFDGNPRLNLASFVTTWMEPECDKLMMESINKNNVE 86
Query: 106 NDEYPQLIHMNERCISMLAKLWQSDT-DRDTPLGCATTGSSEAIMLGGLAMKRQWEKKMR 164
D+YP + RC++M+A+L+ + D + +G T GSSEA+ML GLA KRQW+ K +
Sbjct: 87 MDQYPVTTDLQNRCVNMIARLFNAPLGDGEAAIGVGTVGSSEAVMLAGLAFKRQWQNKRK 146
Query: 165 AANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIG 224
A ++PNI+ + QV LEKFARYF+VE + V + E Y ++P+K + V+ENTI
Sbjct: 147 ALGLPYDRPNIVTGANIQVCLEKFARYFEVELKEVKL-REGYYVMDPDKAVEMVDENTIC 205
Query: 225 IFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQM 284
+ ILG+T TG E+++ + ++L + + W D PIHVD ASGGFI PF + + +
Sbjct: 206 VVAILGSTLTGEFEDVKLLNDLLVE-KNKKTGW---DTPIHVDAASGGFIAPFLYPDLE- 260
Query: 285 ESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEET 344
W F P V SIN SGHK+GL G+GW+VW+ L EL F + YLG + T
Sbjct: 261 -------WDFRLPLVKSINVSGHKYGLVYAGIGWVVWRTKTDLPDELIFHINYLGADQPT 313
Query: 345 FNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVARAFAWKLLQDPDMRDVFEVVSC 404
F LNFS+ QVI QYY L+ LG +GY + R L Q + F +VS
Sbjct: 314 FTLNFSKGSSQVIAQYYQLIRLGFEGYRNVMDN----CRENMMVLRQGLEKTGRFNIVS- 368
Query: 405 LHENLDNSSIAESLDDYWKNPHDYKPGIPLCAFKLSEKFKSEHPEIPQSIISTLLRQKGW 464
EN G+PL AF L + S H E ++ +LR+ GW
Sbjct: 369 -KEN----------------------GVPLVAFSLKDS--SRHNEFE---VAEMLRRFGW 400
Query: 465 IIPNYPLPESTDGSDKKEVLRVVFRIEMKLDMALLLVQDVFEVVQKL 511
I+P Y +P + VLRVV R + +A LV D +V+ +L
Sbjct: 401 IVPAYTMPAD---AQHVTVLRVVIREDFSRTLAERLVADFEKVLHEL 444
>At1g65960 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 494
Score = 297 bits (760), Expect = 3e-80
Identities = 181/470 (38%), Positives = 264/470 (55%), Gaps = 52/470 (11%)
Query: 44 TRIDKFAVPKKGLHSEHVYNLVKNELKLDGNPVLNLASFVNTFTDQFAQKLIDENLNKNL 103
T + K+ + + + + Y ++K+EL LDGNP LNLASFV T+ + KLI +++NKN
Sbjct: 24 TTLPKYEIGENSIPKDAAYQIIKDELMLDGNPRLNLASFVTTWMEPECDKLIMDSINKNY 83
Query: 104 ADNDEYPQLIHMNERCISMLAKLWQSDTDR-DTPLGCATTGSSEAIMLGGLAMKRQWEKK 162
D DEYP + RC++++A+L+ + + +T +G T GSSEAIML GLA KR+W+ K
Sbjct: 84 VDMDEYPVTTELQNRCVNIIARLFNAPLEESETAVGVGTVGSSEAIMLAGLAFKRKWQNK 143
Query: 163 MRAANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYH-LNPNKLWDYVNEN 221
+A K +KPNI+ + QV EKFARYF+VE L V+ GY+ ++P+K + V+EN
Sbjct: 144 RKAEGKPYDKPNIVTGANVQVCWEKFARYFEVE--LKEVNLSEGYYVMDPDKAAEMVDEN 201
Query: 222 TIGIFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTE 281
TI + ILG+T G E+++++ ++L + + W+ PIHVD ASGGFI PF + E
Sbjct: 202 TICVAAILGSTLNGEFEDVKRLNDLLVK-KNEETGWNT---PIHVDAASGGFIAPFIYPE 257
Query: 282 AQMESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGI 341
+ W F P V SIN SGHK+GL G+GW+VW+ E L EL F + YLG
Sbjct: 258 LE--------WDFRLPLVKSINVSGHKYGLVYAGIGWVVWRAAEDLPEELIFHINYLGAD 309
Query: 342 EETFNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVARAFAWKLLQDPDMRDVFEV 401
+ TF LNFS+ Q+I QYY L+ LG +GY M + E
Sbjct: 310 QPTFTLNFSKGSSQIIAQYYQLIRLGFEGYKNV--------------------MENCIEN 349
Query: 402 VSCLHENLDNSSIAESLDDYWKNPHDYKPGIPLCAFKLSEKFKSEHPEIPQSIISTLLRQ 461
+ L E ++ + E + K+ G+P+ AF L K S H E IS +LR+
Sbjct: 350 MVVLKEGIEKT---ERFNIVSKD-----QGVPVVAFSL--KDHSFHNEFE---ISEMLRR 396
Query: 462 KGWIIPNYPLPESTDGSDKKEVLRVVFRIEMKLDMALLLVQDVFEVVQKL 511
GWI+P Y +P + VLRVV R + +A LV D+ +V+ +L
Sbjct: 397 FGWIVPAYTMPAD---AQHITVLRVVIREDFSRTLAERLVADISKVLHEL 443
>At3g17760 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 494
Score = 296 bits (759), Expect = 4e-80
Identities = 175/467 (37%), Positives = 256/467 (54%), Gaps = 50/467 (10%)
Query: 46 IDKFAVPKKGLHSEHVYNLVKNELKLDGNPVLNLASFVNTFTDQFAQKLIDENLNKNLAD 105
+ +F +P + + Y ++ +EL LDGNP LNLASFV T+ + KLI +++NKN D
Sbjct: 26 VPRFKMPDHCMPKDAAYQVINDELMLDGNPRLNLASFVTTWMEPECDKLIMDSVNKNYVD 85
Query: 106 NDEYPQLIHMNERCISMLAKLWQSDTDRD-TPLGCATTGSSEAIMLGGLAMKRQWEKKMR 164
DEYP + RC++M+A L+ + D +GC T GSSEAIML GLA KR+W+ + +
Sbjct: 86 MDEYPVTTELQNRCVNMIANLFHAPVGEDEAAIGCGTVGSSEAIMLAGLAFKRKWQHRRK 145
Query: 165 AANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIG 224
A +KPNI+ + QV EKFARYF+VE + V + ++ Y ++P K + V+ENTI
Sbjct: 146 AQGLPIDKPNIVTGANVQVCWEKFARYFEVELKEVKLSEDY-YVMDPAKAVEMVDENTIC 204
Query: 225 IFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQM 284
+ ILG+T TG E+++Q+ ++L A+ + + PIHVD ASGGFI PF + + +
Sbjct: 205 VAAILGSTLTGEFEDVKQLNDLLAEKNAE----TGWETPIHVDAASGGFIAPFLYPDLE- 259
Query: 285 ESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEET 344
W F P V SIN SGHK+GL G+GW+VW+ + L EL F + YLG + T
Sbjct: 260 -------WDFRLPWVKSINVSGHKYGLVYAGVGWVVWRTKDDLPEELVFHINYLGADQPT 312
Query: 345 FNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVARAFAWKLLQDPDMRDVFEVVSC 404
F LNFS+ Q+I QYY + LG +GY + AR +L + +M F +VS
Sbjct: 313 FTLNFSKGSSQIIAQYYQFIRLGFEGYKNIMENCMDNAR----RLREGIEMTGKFNIVS- 367
Query: 405 LHENLDNSSIAESLDDYWKNPHDYKPGIPLCAFKLSEKFKSEHPEIPQSIISTLLRQKGW 464
G+PL AF L + K EI +S LR+ GW
Sbjct: 368 -----------------------KDIGVPLVAFSLKDSSKHTVFEIAES-----LRKFGW 399
Query: 465 IIPNYPLPESTDGSDKKEVLRVVFRIEMKLDMALLLVQDVFEVVQKL 511
IIP Y +P + VLRVV R + +A L+ + +V++++
Sbjct: 400 IIPAYTMPAD---AQHIAVLRVVIREDFSRGLADRLITHIIQVLKEI 443
>At2g02010 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 493
Score = 296 bits (758), Expect = 6e-80
Identities = 182/467 (38%), Positives = 255/467 (53%), Gaps = 50/467 (10%)
Query: 46 IDKFAVPKKGLHSEHVYNLVKNELKLDGNPVLNLASFVNTFTDQFAQKLIDENLNKNLAD 105
+ +F +P+ + E Y ++ +EL LDGNP LNLASFV T+ + KL+ E++NKN D
Sbjct: 27 LPRFEMPENSIPKEAAYQIINDELMLDGNPRLNLASFVTTWMEPECDKLMMESINKNYVD 86
Query: 106 NDEYPQLIHMNERCISMLAKLWQSDT-DRDTPLGCATTGSSEAIMLGGLAMKRQWEKKMR 164
DEYP + RC++M+A+L+ + D + +G T GSSEAIML GLA KRQW+ K +
Sbjct: 87 MDEYPVTTELQNRCVNMIARLFNAPLGDGEAAVGVGTVGSSEAIMLAGLAFKRQWQNKRK 146
Query: 165 AANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIG 224
A +KPNI+ + QV EKFARYF+VE + V + ++ Y ++P K + V+ENTI
Sbjct: 147 AQGLPYDKPNIVTGANVQVCWEKFARYFEVELKEVNLREDY-YVMDPVKAVEMVDENTIC 205
Query: 225 IFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQM 284
+ ILG+T TG E+++ + ++L Q + D PIHVD ASGGFI PF + E +
Sbjct: 206 VAAILGSTLTGEFEDVKLLNDLLVEKNKQ----TGWDTPIHVDAASGGFIAPFLYPELE- 260
Query: 285 ESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEET 344
W F P V SIN SGHK+GL G+GW+VW+ L EL F + YLG + T
Sbjct: 261 -------WDFRLPLVKSINVSGHKYGLVYAGIGWVVWRTKTDLPDELIFHINYLGADQPT 313
Query: 345 FNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVARAFAWKLLQDPDMRDVFEVVSC 404
F LNFS+ QVI QYY L+ LG +GY + R L Q + F++VS
Sbjct: 314 FTLNFSKGSSQVIAQYYQLIRLGFEGYRNVMDN----CRENMMVLRQGLEKTGRFKIVS- 368
Query: 405 LHENLDNSSIAESLDDYWKNPHDYKPGIPLCAFKLSEKFKSEHPEIPQSIISTLLRQKGW 464
EN G+PL AF L + S H E ++ LR+ GW
Sbjct: 369 -KEN----------------------GVPLVAFSLKDS--SRHNEFE---VAHTLRRFGW 400
Query: 465 IIPNYPLPESTDGSDKKEVLRVVFRIEMKLDMALLLVQDVFEVVQKL 511
I+P Y +P + VLRVV R + +A LV D +V+ +L
Sbjct: 401 IVPAYTMPAD---AQHVTVLRVVIREDFSRTLAERLVADFEKVLHEL 444
>At3g17720 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 194
Score = 106 bits (264), Expect = 1e-22
Identities = 61/166 (36%), Positives = 97/166 (57%), Gaps = 9/166 (5%)
Query: 110 PQLIHMNERCISMLAKLWQSDTDRDTP-LGCATTGSSEAIMLGGLAMKRQWEKKMRAANK 168
P ++ RC++M+A L+ + +D + C SSE+ GLA K +W+ + +A
Sbjct: 27 PTPTSLDNRCVNMIANLFHAPVGQDEAVISCGIVASSES---AGLAFKMKWQHRRKAQGL 83
Query: 169 STEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIGIFVI 228
+KPNI+ QV EKFARYF+VE + V + ++ Y ++P K + V+EN+I + I
Sbjct: 84 PIDKPNIVTGVNVQVCWEKFARYFEVELKEVKLSEDY-YVMDPAKAVEMVDENSICVAAI 142
Query: 229 LGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFI 274
LG+T+TG E ++ + ++L A+ W + PIHVD ASGGFI
Sbjct: 143 LGSTFTGEFEYVKLLNDLLAEKNAK-TAW---ETPIHVDAASGGFI 184
>YDR294c [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 589
Score = 93.6 bits (231), Expect = 7e-19
Identities = 79/321 (24%), Positives = 147/321 (45%), Gaps = 34/321 (10%)
Query: 107 DEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCATTGSSEAIMLGGLAMKRQWEKKMRAA 166
D +P + M +SM+ +++ + +D T G T+G +E+++L L+ K
Sbjct: 200 DVFPAVRKMESEVVSMVLRMFNAPSD--TGCGTTTSGGTESLLLACLSAKMY-----ALH 252
Query: 167 NKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIGIF 226
++ +P II +K A YF ++ R V +D Y ++ K+ ++N+NTI +
Sbjct: 253 HRGITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTT-YQVDLGKVKKFINKNTILLV 311
Query: 227 VILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQMES 286
G ++IE + ++ + + +P+HVD G FIV F ME
Sbjct: 312 GSAPNFPHGIADDIEGLGKIAQKYK----------LPLHVDSCLGSFIVSF------MEK 355
Query: 287 YG---LGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEE 343
G L F P V SI+ HK+G G I+++N + + + + GG+
Sbjct: 356 AGYKNLPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYG 415
Query: 344 TFNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVARAFAWKLLQD--PDMRDV--- 398
+ L SRPG V+ + ++ +G+ GY E + + A F K +Q+ PD+ +
Sbjct: 416 SPTLAGSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFK-KYIQENIPDLNIMGNP 474
Query: 399 -FEVVSCLHENLDNSSIAESL 418
+ V+S + L+ +++ L
Sbjct: 475 RYSVISFSSKTLNIHELSDRL 495
>7302829 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 545
Score = 91.3 bits (225), Expect = 4e-18
Identities = 86/343 (25%), Positives = 143/343 (41%), Gaps = 38/343 (11%)
Query: 51 VPKKGLHSEHVYNLVKNELKL------DGNPVLNLASFVNTFTDQFAQKLIDENLNKNLA 104
+P+KGL E + LV LK DG ++ V + + L+ E K
Sbjct: 103 LPEKGLSKEEILRLVDEHLKTGHYNWRDGR----VSGAVYGYKPDLVE-LVTEVYGKASY 157
Query: 105 DN----DEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCATTGSSEAIMLGGLAMKRQWE 160
N D +P + M + M L+ ++ G TTG +E+I++ AMK
Sbjct: 158 TNPLHADLFPGVCKMEAEVVRMACNLFHGNS---ASCGTMTTGGTESIVM---AMKAY-- 209
Query: 161 KKMRAANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNE 220
+ K +PNI++ A +K +YF++ R V VD E Y ++ K +N
Sbjct: 210 RDFAREYKGITRPNIVVPKTVHAAFDKGGQYFNIHVRSVDVDPET-YEVDIKKFKRAINR 268
Query: 221 NTIGIFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFT 280
NTI + G +++IE +A + DIP+HVD G F+V
Sbjct: 269 NTILLVGSAPNFPYGTIDDIEAIAAL----------GVKYDIPVHVDACLGSFVVALV-- 316
Query: 281 EAQMESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGG 340
+ Y L + F V SI+ HK+G G I++ + +Y + + GG
Sbjct: 317 --RNAGYKLRPFDFEVKGVTSISADTHKYGFAPKGSSVILYSDKKYKDHQFTVTTDWPGG 374
Query: 341 IEETFNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVAR 383
+ + +N SR G + + +++ G GY E + + AR
Sbjct: 375 VYGSPTVNGSRAGGIIAACWATMMSFGYDGYLEATKRIVDTAR 417
>CE20348 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 552
Score = 81.3 bits (199), Expect = 4e-15
Identities = 85/366 (23%), Positives = 150/366 (40%), Gaps = 44/366 (12%)
Query: 38 LESV-KDTRIDKF--AVPKKGLHSEHVYNLVK-----NELKLDGNPVLNLASFVNTFTDQ 89
+ES+ KD + +F +P L + + L K N +DG V +TD+
Sbjct: 93 IESIHKDDKDKQFISTLPIAPLSQDSIMELAKKYEDYNTFNIDGGRVSGAV-----YTDR 147
Query: 90 FAQ------KLIDENLNKNLADNDEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCATTG 143
A+ K+ ++ N D +P M I M+ L+ D G T+G
Sbjct: 148 HAEHINLLGKIYEKYAFSNPLHPDVFPGARKMEAELIRMVLNLYNGPEDSS---GSVTSG 204
Query: 144 SSEAIMLGGLAMKRQWEKKMRAANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDT 203
+E+I++ + + RA + E P I+ A +K A + R VPVD+
Sbjct: 205 GTESIIMACFSYRN------RAHSLGIEHPVILACKTAHAAFDKAAHLCGMRLRHVPVDS 258
Query: 204 EHGYHLNPNKLWDYVNENTIGIFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIP 263
++ L ++ ++ N + +G ++ I ++A++ IP
Sbjct: 259 DNRVDLK--EMERLIDSNVCMLVGSAPNFPSGTIDPIPEIAKL----------GKKYGIP 306
Query: 264 IHVDGASGGFIVPFAFTEAQMESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKN 323
+HVD GGF++PF Y + + F +P V SI+ HK+G T G +++++
Sbjct: 307 VHVDACLGGFMIPF----MNDAGYLIPVFDFRNPGVTSISCDTHKYGCTPKGSSIVMYRS 362
Query: 324 DEYLLPELRFKLKYLGGIEETFNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVAR 383
E + + GGI T + SR G + LL+ G+ Y + Q + R
Sbjct: 363 KELHHFQYFSVADWCGGIYATPTIAGSRAGANTAVAWATLLSFGRDEYVRRCAQIVKHTR 422
Query: 384 AFAWKL 389
A K+
Sbjct: 423 MLAEKI 428
>CE06695 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 542
Score = 80.5 bits (197), Expect = 6e-15
Identities = 76/293 (25%), Positives = 133/293 (44%), Gaps = 33/293 (11%)
Query: 84 NTFTDQFAQKLIDENLNKNLADNDEYPQLIH----MNERCISMLAKLWQSDTDRDTPLGC 139
N D+ +++ +E K N +P+L M + M + D++ G
Sbjct: 137 NREDDKDEREMYEEVFGKFAWTNPLWPKLFPGVRIMEAEVVRMCCNMMNGDSET---CGT 193
Query: 140 ATTGSSEAIMLGGLAMKRQWEKKMRAANKSTEKPNIIMSSACQVALEKFARYFDVECRLV 199
+TG S +I+L LA + + K+ K TE +I+ S+ A K A F ++ R +
Sbjct: 194 MSTGGSISILLACLAHRNRLLKR---GEKYTE---MIVPSSVHAAFFKAAECFRIKVRKI 247
Query: 200 PVDTEHGYHLNPNKLWDYVNENTIGIFVILGTTYTGHLENIEQVAEV-LEHIEAQHPDWS 258
PVD + ++ K+ +N+ T + G +++IE + ++ LE+
Sbjct: 248 PVDPVT-FKVDLVKMKAAINKRTCMLVGSAPNFPFGTVDDIEAIGQLGLEY--------- 297
Query: 259 NKDIPIHVDGASGGFIVPFAFTEAQMESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGW 318
DIP+HVD GGF++PF E ++ R+ F P V SI+ HK+GL G
Sbjct: 298 --DIPVHVDACLGGFLLPF-LEEDEI------RYDFRVPGVSSISADSHKYGLAPKGSSV 348
Query: 319 IVWKNDEYLLPELRFKLKYLGGIEETFNLNFSRPGFQVIHQYYNLLTLGQQGY 371
++++N E L + + GGI + + SR G + + +L Q+GY
Sbjct: 349 VLYRNKELLHNQYFCDADWQGGIYASATMEGSRAGHNIALCWAAMLYHAQEGY 401
>CE26034 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 554
Score = 79.3 bits (194), Expect = 1e-14
Identities = 66/284 (23%), Positives = 119/284 (41%), Gaps = 24/284 (8%)
Query: 106 NDEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCATTGSSEAIMLGGLAMKRQWEKKMRA 165
+D +P + M + M ++ D G G +EA+ML LA + R+
Sbjct: 118 SDAFPGVRKMEAEILKMTCAMFHGGKDS---CGVVAGGGTEALMLACLAYRN------RS 168
Query: 166 ANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIGI 225
+ + I+ S AL+K A +FD+ + + V +E N + + T I
Sbjct: 169 RARGEWRAEIVAPSTAHPALDKAAAFFDMTIKRIQV-SETDDRANVGAMKRAIGPRTCMI 227
Query: 226 FVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQME 285
TG ++ IE++A++ + IP+HVD GGF++PF +
Sbjct: 228 IASAPNHITGTVDPIEKLAKLAQRYH----------IPLHVDCTLGGFVLPFM----EYA 273
Query: 286 SYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEETF 345
Y + + F P V SI+ H++G L ++++ +L + ++ GG T
Sbjct: 274 DYSVPAFDFRLPGVTSISADLHRYGQCPGRLSVLMYREPAFLRHQFFTNSEWPGGCYATP 333
Query: 346 NLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVARAFAWKL 389
++ R G V + +L G+ GY + I R A++L
Sbjct: 334 TMSGGRDGGAVATAWAMMLRKGRDGYINAAQRIIEATRQLAYRL 377
>At1g27980 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 544
Score = 78.2 bits (191), Expect = 3e-14
Identities = 65/269 (24%), Positives = 122/269 (45%), Gaps = 23/269 (8%)
Query: 107 DEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCA--TTGSSEAIMLGGLAMKRQWEKKMR 164
D + ++ ++M A L S C T+G +E+I+L + + + K
Sbjct: 167 DVFQSVVRFESEVVAMTAALLGSKETASGGQICGNMTSGGTESIVLAVKSSRDYMKYK-- 224
Query: 165 AANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIG 224
K +P +I+ + A +K A+YF ++ VPVD + + + ++N NTI
Sbjct: 225 ---KGITRPEMIIPESGHSAYDKAAQYFKIKLWRVPVDKDFRADVKATRR--HINRNTIM 279
Query: 225 IFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQM 284
I G ++ IE++ ++ + I HVD GGF++PFA +
Sbjct: 280 IVGSAPGFPHGIIDPIEELGQLA----------LSYGICFHVDLCLGGFVLPFA----RK 325
Query: 285 ESYGLGRWGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEET 344
Y + + F+ V SI+ HK+GL G ++++N E + ++ GG+ +
Sbjct: 326 LGYQIPPFDFSVQGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWSGGLYVS 385
Query: 345 FNLNFSRPGFQVIHQYYNLLTLGQQGYYE 373
+ SRPG V + +++LG++GY +
Sbjct: 386 PTIAGSRPGSLVAGAWAAMMSLGEEGYLQ 414
>Hs10190653 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 568
Score = 69.3 bits (168), Expect = 1e-11
Identities = 77/340 (22%), Positives = 133/340 (38%), Gaps = 32/340 (9%)
Query: 50 AVPKKGLHSEHVYNLVKNELKLD-----GNPVLNLASFVNTFTDQFAQKLIDENLNKNLA 104
A+P +GL S V +K +D G + S T+ K + N
Sbjct: 115 ALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLV-KAYGDFAWSNPL 173
Query: 105 DNDEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCATTGSSEAIMLGGLAMKRQWEKKMR 164
D +P L + + + L+ D GC T+G +E+I++ A +
Sbjct: 174 HPDIFPGLRKIEAEIVRIACSLFNGGPDS---CGCVTSGGTESILMACKAYRDL------ 224
Query: 165 AANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIG 224
A K + P I+ + A K A YF ++ VP+ ++ + ++ NT
Sbjct: 225 AFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKM--MEVDVRAMRRAISRNTAM 282
Query: 225 IFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQM 284
+ G ++ + +VA++ + IP+HVD GGF++ F +
Sbjct: 283 LVCSTPQFPHGVIDPVPEVAKLAVKYK----------IPLHVDACLGGFLIVFM----EK 328
Query: 285 ESYGLGR-WGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEE 343
Y L + F V SI+ HK+G G +++ + +Y + + GGI
Sbjct: 329 AGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYA 388
Query: 344 TFNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVAR 383
+ + SRPG + L+ G+ GY E Q I AR
Sbjct: 389 SPTIAGSRPGGISAAAWAALMHFGENGYVEATKQIIKTAR 428
>Hs20471012 [E] KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase
Length = 568
Score = 68.6 bits (166), Expect = 2e-11
Identities = 77/340 (22%), Positives = 133/340 (38%), Gaps = 32/340 (9%)
Query: 50 AVPKKGLHSEHVYNLVKNELKLD-----GNPVLNLASFVNTFTDQFAQKLIDENLNKNLA 104
A+P +GL S V +K +D G + S T+ K + N
Sbjct: 115 ALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLV-KAYGDFAWSNPL 173
Query: 105 DNDEYPQLIHMNERCISMLAKLWQSDTDRDTPLGCATTGSSEAIMLGGLAMKRQWEKKMR 164
D +P L + + + L+ D GC T+G +E+I++ A +
Sbjct: 174 HPDIFPGLRKIEAEIVRIACSLFNGGPDS---CGCVTSGGTESILMACKAYRDL------ 224
Query: 165 AANKSTEKPNIIMSSACQVALEKFARYFDVECRLVPVDTEHGYHLNPNKLWDYVNENTIG 224
A K + P I+ + A K A YF ++ VP+ ++ + ++ NT
Sbjct: 225 AFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKM--MEVDVRAMRRAISRNTAM 282
Query: 225 IFVILGTTYTGHLENIEQVAEVLEHIEAQHPDWSNKDIPIHVDGASGGFIVPFAFTEAQM 284
+ G ++ + +VA++ + IP+HVD GGF++ F +
Sbjct: 283 LVCSTPQFPHGVIDPVPEVAKLAVKYK----------IPLHVDACLGGFLIVFM----EK 328
Query: 285 ESYGLGR-WGFNHPRVVSINTSGHKFGLTTPGLGWIVWKNDEYLLPELRFKLKYLGGIEE 343
Y L + F V SI+ HK+G G +++ + +Y + + GGI
Sbjct: 329 AGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYA 388
Query: 344 TFNLNFSRPGFQVIHQYYNLLTLGQQGYYEKFNQSIFVAR 383
+ + SRPG + L+ G+ GY E Q I AR
Sbjct: 389 SPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTAR 428
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,035,750
Number of Sequences: 60738
Number of extensions: 1690787
Number of successful extensions: 4458
Number of sequences better than 1.0e-05: 15
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 4406
Number of HSP's gapped (non-prelim): 19
length of query: 567
length of database: 30,389,216
effective HSP length: 112
effective length of query: 455
effective length of database: 23,586,560
effective search space: 10731884800
effective search space used: 10731884800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)