ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3608 good R KOG1729 General function prediction only FYVE finger containing protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3608 1272215 1273192 326
(326 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR313c [R] KOG1729 FYVE finger containing protein 232 5e-61
SPBC36B7.05c [R] KOG1729 FYVE finger containing protein 97 3e-20
Hs7662048 [V] KOG1841 Smad anchor for receptor activation 64 2e-10
Hs6552339 [V] KOG1841 Smad anchor for receptor activation 63 7e-10
Hs6552337 [V] KOG1841 Smad anchor for receptor activation 61 3e-09
Hs4759060 [V] KOG1841 Smad anchor for receptor activation 61 3e-09
Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and... 60 3e-09
Hs10863893 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosp... 60 3e-09
Hs13376757 [R] KOG1729 FYVE finger containing protein 60 4e-09
Hs13470092 [R] KOG1729 FYVE finger containing protein 60 6e-09
Hs10835109 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosp... 60 6e-09
At3g43230 [S] KOG1843 Uncharacterized conserved protein 57 3e-08
7291295 [V] KOG1841 Smad anchor for receptor activation 56 6e-08
CE24610 [O] KOG0801 Predicted E3 ubiquitin ligase 56 8e-08
At4g33240 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase ... 56 8e-08
At1g20110 [R] KOG1729 FYVE finger containing protein 56 8e-08
YFR019w [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase an... 55 1e-07
CE19557 [R] KOG1819 FYVE finger-containing proteins 55 1e-07
CE01110 [R] KOG1729 FYVE finger containing protein 55 1e-07
Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling p... 55 1e-07
7290174 [R] KOG1729 FYVE finger containing protein 55 1e-07
Hs8922921 [R] KOG1729 FYVE finger containing protein 54 2e-07
At3g14270 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase ... 54 4e-07
7302711 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase an... 54 4e-07
Hs14784247 [R] KOG1811 Predicted Zn2+-binding protein contains F... 53 7e-07
7299446 [R] KOG1811 Predicted Zn2+-binding protein contains FYVE... 53 7e-07
SPBC9B6.03 [R] KOG1729 FYVE finger containing protein 52 9e-07
SPAC19A8.05c [TU] KOG1818 Membrane trafficking and cell signalin... 52 9e-07
Hs11641241 [R] KOG1842 FYVE finger-containing protein 51 3e-06
CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 50 3e-06
YNR006w [TU] KOG1818 Membrane trafficking and cell signaling pro... 50 4e-06
Hs14150005 [O] KOG0801 Predicted E3 ubiquitin ligase 50 4e-06
Hs13375827 [R] KOG1729 FYVE finger containing protein 50 6e-06
CE29111 [R] KOG1842 FYVE finger-containing protein 50 6e-06
CE18979 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase an... 49 8e-06
>YDR313c [R] KOG1729 FYVE finger containing protein
Length = 286
Score = 232 bits (592), Expect = 5e-61
Identities = 125/303 (41%), Positives = 166/303 (54%), Gaps = 33/303 (10%)
Query: 37 ISSQFVNEFGEWEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRV 96
I +N W+ DE C C FSFLVRRHHCRCCGRI+C++C F Y+K RV
Sbjct: 3 IKEDCINNLARWQADEEAHSCFQCKTNFSFLVRRHHCRCCGRIFCSSCTENFVNYNKKRV 62
Query: 97 KVVLKSPAEYEMEPYRTCDSCYENLLQMKLLRTAWGE----IQLPKPPRRIGNSMGXXXX 152
+ K ++ E PYRTC+ CY+NLL + LL ++ Q PP + S
Sbjct: 63 HALQKKNSDVESPPYRTCNECYDNLLHLNLLVSSTNRDVRLSQTSVPPNALALSAPDSNT 122
Query: 153 XXXXXXXXXRPFEFMKNQNVVENVRETESERNSPRNIHAADEDYDRCPICNFDLQVFGSE 212
+ +V ++ SE +S +E+ CPICN DL F E
Sbjct: 123 DEDAE---------ILEDSVDQSGTACRSEESS------QNEEDHFCPICNSDLTQFPDE 167
Query: 213 EAAQQEHVSECIRQAELAQQ--------QHSLIGSPTYQNRMLVYQIPKNATN--IQECP 262
E ++HV +CI++AE AQQ S+ SP +QNRMLVY+I N T+ I+ECP
Sbjct: 168 EET-RKHVEDCIQRAENAQQHTNTSDAADDSVKESPAFQNRMLVYKISPNTTDNAIKECP 226
Query: 263 ICFEEMAPGQKVGRLECLCVFHYHCIKSWFKKKVQKLATVNSATQDSVSMLGKNYCPFHD 322
ICFE M PG+KVGRLECLCVFHY CIK+WF K+ Q A + + + +N+CPFHD
Sbjct: 227 ICFENMEPGEKVGRLECLCVFHYKCIKNWFHKRAQMTAAQKG---NGHAFVKRNFCPFHD 283
Query: 323 AVY 325
AV+
Sbjct: 284 AVF 286
>SPBC36B7.05c [R] KOG1729 FYVE finger containing protein
Length = 279
Score = 97.1 bits (240), Expect = 3e-20
Identities = 73/273 (26%), Positives = 116/273 (41%), Gaps = 64/273 (23%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAE-- 105
W+ D+ QC +CG F++ RRHHCR CG+++C CC+ FA K V V P E
Sbjct: 24 WQLDDESAQCNNCGGPFTWFRRRHHCRWCGKLFCYNCCNSFA---KLPVSSVSVDPTEDL 80
Query: 106 -----YEMEP--------------------YRTCDSCYENLLQMKLLRTAWGEIQLPKPP 140
+ +P R C +C + L ++K E+ LP P
Sbjct: 81 IPQDMFIRDPDFLANDNDDDNDSQDSSWINVRVCVNCRQQLSELK-------ELDLPYPI 133
Query: 141 RRIGNSMGXXXXXXXXXXXXXRPFEFMKNQNVVENVRETESERNSPRNIHAADEDYDRCP 200
N N V+++ S N+ + I D D+ CP
Sbjct: 134 TTCLNDDTTTRS----------------NNQVIQS-----SCGNNLQRIEEPD-DFVECP 171
Query: 201 ICNFDLQVFGSEEAAQQEHVSECIRQAELAQQQHSLIGSPTYQNRMLVYQIPKNATNI-Q 259
+C L F + + ++ HV+ C+ + + ++ + R + Q+ + + + Q
Sbjct: 172 VCYAPLSSFKTL-SERESHVANCL--SNNSSSPRNMTEFLKHARRYISMQLSETSPCLGQ 228
Query: 260 ECPICFEEMAPGQKVGRLE-CLCVFHYHCIKSW 291
EC ICFEE A G +V R+E CLC+FH C + W
Sbjct: 229 ECIICFEEFAAGDRVARIEYCLCIFHLKCYRDW 261
>Hs7662048 [V] KOG1841 Smad anchor for receptor activation
Length = 1539
Score = 64.3 bits (155), Expect = 2e-10
Identities = 25/74 (33%), Positives = 37/74 (49%), Gaps = 13/74 (17%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYE 107
W D C++C +KF+F RRHHCR CG+++C CC++ K +Y
Sbjct: 744 WVPDSEAPNCMNCQVKFTFTKRRHHCRACGKVFCGVCCNR-------------KCKLQYL 790
Query: 108 MEPYRTCDSCYENL 121
+ R C CYE +
Sbjct: 791 EKEARVCVVCYETI 804
>Hs6552339 [V] KOG1841 Smad anchor for receptor activation
Length = 1210
Score = 62.8 bits (151), Expect = 7e-10
Identities = 28/87 (32%), Positives = 41/87 (46%), Gaps = 15/87 (17%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCS---KFAWYDKNRVKVVLKSPA 104
W D C+ C +F+F RRHHCR CG+++CA+CCS K + D+ +V +
Sbjct: 696 WVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARVCV---- 751
Query: 105 EYEMEPYRTCDSCYENLLQMKLLRTAW 131
C S N+ Q + R W
Sbjct: 752 --------ICHSVLMNVAQPREQRRVW 770
>Hs6552337 [V] KOG1841 Smad anchor for receptor activation
Length = 762
Score = 60.8 bits (146), Expect = 3e-09
Identities = 22/54 (40%), Positives = 32/54 (58%), Gaps = 3/54 (5%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCS---KFAWYDKNRVKV 98
W D C+ C +F+F RRHHCR CG+++CA+CCS K + D+ +V
Sbjct: 696 WVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARV 749
>Hs4759060 [V] KOG1841 Smad anchor for receptor activation
Length = 1323
Score = 60.8 bits (146), Expect = 3e-09
Identities = 22/54 (40%), Positives = 32/54 (58%), Gaps = 3/54 (5%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCS---KFAWYDKNRVKV 98
W D C+ C +F+F RRHHCR CG+++CA+CCS K + D+ +V
Sbjct: 594 WVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFCASCCSLKCKLLYMDRKEARV 647
>Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 1513
Score = 60.5 bits (145), Expect = 3e-09
Identities = 29/74 (39%), Positives = 39/74 (52%), Gaps = 11/74 (14%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYE 107
W KDE C C ++FS RRHHCR CG+++C CS+F + R+K+
Sbjct: 1438 WVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQK-CSRFQ-SEIKRLKI--------- 1486
Query: 108 MEPYRTCDSCYENL 121
P R C +CY NL
Sbjct: 1487 SSPVRVCQNCYYNL 1500
>Hs10863893 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 1195
Score = 60.5 bits (145), Expect = 3e-09
Identities = 32/96 (33%), Positives = 45/96 (46%), Gaps = 13/96 (13%)
Query: 44 EFGEWEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSP 103
E W D + C +C +F RRHHCR CG ++CA CC + L P
Sbjct: 1107 EVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCC-----------HLKLPIP 1155
Query: 104 AEYEMEPYRTCDSCYENLLQMKLLRTAWGEIQLPKP 139
+ +P C+SCYE+ +Q+ R + QL KP
Sbjct: 1156 DQQLYDPVLVCNSCYEH-IQVSRARELMSQ-QLKKP 1189
>Hs13376757 [R] KOG1729 FYVE finger containing protein
Length = 310
Score = 60.1 bits (144), Expect = 4e-09
Identities = 31/76 (40%), Positives = 39/76 (50%), Gaps = 13/76 (17%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYE 107
W KD+ T C C +FS R+HHCR CG I+C TC S ++ L S
Sbjct: 241 WLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSN---------ELALPS----Y 287
Query: 108 MEPYRTCDSCYENLLQ 123
+P R CDSC+ LLQ
Sbjct: 288 PKPVRVCDSCHTLLLQ 303
>Hs13470092 [R] KOG1729 FYVE finger containing protein
Length = 1478
Score = 59.7 bits (143), Expect = 6e-09
Identities = 28/74 (37%), Positives = 39/74 (51%), Gaps = 13/74 (17%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYE 107
W D CL C +FS++VRRHHCR CGRI+C CC+ + V+ K + E
Sbjct: 1170 WLGDTEANHCLDCKREFSWMVRRHHCRICGRIFCYYCCNNY---------VLSKHGGKKE 1220
Query: 108 MEPYRTCDSCYENL 121
R C +C++ L
Sbjct: 1221 ----RCCRACFQKL 1230
>Hs10835109 [IU] KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase
myotubularin MTM1
Length = 1198
Score = 59.7 bits (143), Expect = 6e-09
Identities = 27/78 (34%), Positives = 39/78 (49%), Gaps = 11/78 (14%)
Query: 44 EFGEWEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSP 103
E W D C +C F R+HHCR CG ++C++CC++ +V V P
Sbjct: 1112 EMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQ-------KVPV----P 1160
Query: 104 AEYEMEPYRTCDSCYENL 121
++ EP R C SCY +L
Sbjct: 1161 SQQLFEPSRVCKSCYSSL 1178
>At3g43230 [S] KOG1843 Uncharacterized conserved protein
Length = 485
Score = 57.4 bits (137), Expect = 3e-08
Identities = 34/96 (35%), Positives = 46/96 (47%), Gaps = 15/96 (15%)
Query: 47 EWEKDENVTQCLSCGIKFSFLV-RRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAE 105
EW D + C+ C F+ + RHHCR CG I+C C K R + P+
Sbjct: 171 EWLPDSLASTCMQCSTPFTAITCGRHHCRFCGGIFCRNC-------SKGRCLM----PSR 219
Query: 106 Y-EMEPYRTCDSCYENL--LQMKLLRTAWGEIQLPK 138
+ E P R CDSCYE L LQ L+ + +Q+ K
Sbjct: 220 FRERNPQRVCDSCYERLDPLQCVLINSISNAVQVAK 255
>7291295 [V] KOG1841 Smad anchor for receptor activation
Length = 1291
Score = 56.2 bits (134), Expect = 6e-08
Identities = 19/40 (47%), Positives = 26/40 (64%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSK 87
W D QC+ C KF+ + RRHHCR CG++ C+ CCS+
Sbjct: 528 WVPDNMAGQCMQCQQKFTMIKRRHHCRACGKVLCSVCCSQ 567
>CE24610 [O] KOG0801 Predicted E3 ubiquitin ligase
Length = 143
Score = 55.8 bits (133), Expect = 8e-08
Identities = 30/98 (30%), Positives = 50/98 (50%), Gaps = 23/98 (23%)
Query: 198 RCPICNFDLQVFGSEEAAQQEHVSECIRQAELAQQQHSLIGSPTYQNRMLVYQIPKNATN 257
+CP+C+ +V S++A H+ C+ + ++ TY + +L +
Sbjct: 59 KCPVCH---KVVPSDDA--DIHLVMCLTRPKI-----------TYNDDVL-------KDD 95
Query: 258 IQECPICFEEMAPGQKVGRLECLCVFHYHCIKSWFKKK 295
EC IC E++ G K+ RL CLC++H CI WFK+K
Sbjct: 96 KGECSICLEDLEAGHKIARLPCLCIYHKQCIDDWFKRK 133
>At4g33240 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 1757
Score = 55.8 bits (133), Expect = 8e-08
Identities = 27/82 (32%), Positives = 39/82 (46%), Gaps = 7/82 (8%)
Query: 38 SSQFVNEFGEWEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVK 97
SS +F W D++ C C +F+ RRHHCR CGR++CA C + + K
Sbjct: 25 SSNMSRDF--WMPDQSCPVCYECDAQFTVFNRRHHCRLCGRVFCAKCAANSIPSPSDETK 82
Query: 98 VVLKSPAEYEMEPYRTCDSCYE 119
+ E E R C+ CY+
Sbjct: 83 -----DSHEEPERIRVCNYCYK 99
>At1g20110 [R] KOG1729 FYVE finger containing protein
Length = 613
Score = 55.8 bits (133), Expect = 8e-08
Identities = 28/80 (35%), Positives = 37/80 (46%), Gaps = 11/80 (13%)
Query: 44 EFGEWEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSP 103
E W DE V++C SCG F +RRHHCR CG ++C C + R+ +
Sbjct: 448 EKDHWVPDEAVSKCTSCGSDFGAFIRRHHCRNCGDVFCDKC-------TQGRIALT---- 496
Query: 104 AEYEMEPYRTCDSCYENLLQ 123
AE R CD C + Q
Sbjct: 497 AEDNAPQVRVCDRCMAEVSQ 516
>YFR019w [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 2278
Score = 55.5 bits (132), Expect = 1e-07
Identities = 27/78 (34%), Positives = 39/78 (49%), Gaps = 22/78 (28%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCC-----SKFAWYDKNRVKVVLKS 102
W KDE+ +C SCG F+ R+HHCR CG+I+C++C +F + K RV
Sbjct: 237 WMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCTLLIDGDRFGCHAKMRV------ 290
Query: 103 PAEYEMEPYRTCDSCYEN 120
C +CYE+
Sbjct: 291 -----------CYNCYEH 297
>CE19557 [R] KOG1819 FYVE finger-containing proteins
Length = 658
Score = 55.5 bits (132), Expect = 1e-07
Identities = 27/61 (44%), Positives = 37/61 (60%), Gaps = 8/61 (13%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATC-CSKFA----WYDKNRVKVVLKS 102
W DE+ QC +C + F+F+ RRHHCR CGRI+C C C+ + YD+ K V+ S
Sbjct: 563 WVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIFCHKCSCNTISIPEHGYDR---KPVVSS 619
Query: 103 P 103
P
Sbjct: 620 P 620
>CE01110 [R] KOG1729 FYVE finger containing protein
Length = 266
Score = 55.5 bits (132), Expect = 1e-07
Identities = 26/75 (34%), Positives = 36/75 (47%), Gaps = 13/75 (17%)
Query: 48 WEKDENVTQCLSCG-IKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEY 106
W D +C+ CG +F+ + RRHHCR CGR+ C C S+ D K
Sbjct: 149 WVPDGEAVKCMVCGKTQFNLVQRRHHCRNCGRVVCGACSSRTFRIDNVHKK--------- 199
Query: 107 EMEPYRTCDSCYENL 121
P R CD C+++L
Sbjct: 200 ---PVRVCDHCFDSL 211
>Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 777
Score = 55.1 bits (131), Expect = 1e-07
Identities = 22/66 (33%), Positives = 35/66 (52%), Gaps = 11/66 (16%)
Query: 56 QCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYEMEPYRTCD 115
+C C ++F + R+HHCR CG+I+C C SK++ K ++ + R C+
Sbjct: 165 ECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIE-----------KEVRVCE 213
Query: 116 SCYENL 121
CYE L
Sbjct: 214 PCYEQL 219
>7290174 [R] KOG1729 FYVE finger containing protein
Length = 316
Score = 55.1 bits (131), Expect = 1e-07
Identities = 27/80 (33%), Positives = 38/80 (46%), Gaps = 13/80 (16%)
Query: 43 NEFGEWEKDENVTQCLSCG-IKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLK 101
N W D + + C+ C +F+F+ RRHHCR CG + CA C +K + K +
Sbjct: 144 NHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKAL-- 201
Query: 102 SPAEYEMEPYRTCDSCYENL 121
R CD+CYE L
Sbjct: 202 ----------RVCDACYERL 211
>Hs8922921 [R] KOG1729 FYVE finger containing protein
Length = 432
Score = 54.3 bits (129), Expect = 2e-07
Identities = 26/77 (33%), Positives = 37/77 (47%), Gaps = 12/77 (15%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYE 107
W D T C+ C +F+ RRHHCR CG+I C C S D LK+
Sbjct: 221 WIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLD------YLKN----- 269
Query: 108 MEPYRTCDSCYENLLQM 124
+P R C+ C++ L ++
Sbjct: 270 -QPARVCEHCFQELQKL 285
>At3g14270 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 1791
Score = 53.5 bits (127), Expect = 4e-07
Identities = 26/74 (35%), Positives = 39/74 (52%), Gaps = 11/74 (14%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSK---FAWYDKNRVKVVLKSPA 104
W D++ C C +F+ + RRHHCR CGR++C C + FA D L++P
Sbjct: 36 WMPDQSCRVCYECDCQFTLINRRHHCRHCGRVFCGKCTANSIPFAPSD-------LRTPR 88
Query: 105 EYEMEPYRTCDSCY 118
E + E R C+ C+
Sbjct: 89 E-DWERIRVCNYCF 101
>7302711 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 1809
Score = 53.5 bits (127), Expect = 4e-07
Identities = 18/40 (45%), Positives = 25/40 (62%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSK 87
W D +C C KFS R+HHCR CG+I+C+ CC++
Sbjct: 183 WMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQ 222
>Hs14784247 [R] KOG1811 Predicted Zn2+-binding protein contains FYVE domain
Length = 989
Score = 52.8 bits (125), Expect = 7e-07
Identities = 27/73 (36%), Positives = 39/73 (52%), Gaps = 13/73 (17%)
Query: 47 EWEKDENVTQCLSCGIK-FSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAE 105
+W DE + C+ C + F+ RRHHCR CGR+ C++C +K K+V++ E
Sbjct: 258 QWVPDETESICMVCCREHFTMFNRRHHCRRCGRLVCSSCSTK---------KMVVEGCRE 308
Query: 106 YEMEPYRTCDSCY 118
P R CD CY
Sbjct: 309 ---NPARVCDQCY 318
>7299446 [R] KOG1811 Predicted Zn2+-binding protein contains FYVE domain
Length = 2176
Score = 52.8 bits (125), Expect = 7e-07
Identities = 24/72 (33%), Positives = 38/72 (52%), Gaps = 12/72 (16%)
Query: 47 EWEKDENVTQCLSCG-IKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAE 105
+W +DE + C+ C F+ L+RRHHCR CGR+ C C + +R+++ P
Sbjct: 1434 QWTRDEEASHCMCCRRAAFTMLMRRHHCRRCGRVVCYACST-------HRIRI----PEL 1482
Query: 106 YEMEPYRTCDSC 117
Y+ R C+ C
Sbjct: 1483 YDELEVRICNDC 1494
>SPBC9B6.03 [R] KOG1729 FYVE finger containing protein
Length = 293
Score = 52.4 bits (124), Expect = 9e-07
Identities = 28/80 (35%), Positives = 41/80 (51%), Gaps = 9/80 (11%)
Query: 48 WEKDENVTQCL--SCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAE 105
W+ D +V+ C SC ++F RRHHCR CG I+CA C D+N + + +
Sbjct: 151 WKPDSDVSVCSFPSCSVRFGLFDRRHHCRRCGDIFCALHC------DRN-IPLTMDVKFC 203
Query: 106 YEMEPYRTCDSCYENLLQMK 125
YR+C SC+ L+ K
Sbjct: 204 LAGSLYRSCVSCFYEYLKWK 223
>SPAC19A8.05c [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 610
Score = 52.4 bits (124), Expect = 9e-07
Identities = 25/62 (40%), Positives = 30/62 (48%), Gaps = 11/62 (17%)
Query: 57 CLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYEMEPYRTCDS 116
CL C F+F R+HHCR CG ++C C SK L P +P R CDS
Sbjct: 176 CLRCRTPFTFTNRKHHCRNCGGVFCNQCSSK-----------TLSLPHLGINQPVRVCDS 224
Query: 117 CY 118
CY
Sbjct: 225 CY 226
>Hs11641241 [R] KOG1842 FYVE finger-containing protein
Length = 784
Score = 50.8 bits (120), Expect = 3e-06
Identities = 24/71 (33%), Positives = 33/71 (45%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYE 107
W D++V C CG KFS RRHHCR CG I C C + N++ K
Sbjct: 154 WVNDQDVPFCPDCGNKFSIRNRRHHCRLCGSIMCKKCMELISLPLANKLTSASKESLSTH 213
Query: 108 MEPYRTCDSCY 118
P ++ +S +
Sbjct: 214 TSPSQSPNSVH 224
>CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 931
Score = 50.4 bits (119), Expect = 3e-06
Identities = 26/76 (34%), Positives = 39/76 (51%), Gaps = 11/76 (14%)
Query: 48 WEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYE 107
W +D +C C KF+ R+HHCR CG+I+C+T CS+F + R+ +
Sbjct: 860 WVQDVTRQRCDDCEHKFTLADRKHHCRNCGQIFCST-CSRFESH-ITRMNI--------- 908
Query: 108 MEPYRTCDSCYENLLQ 123
P R C C++ L Q
Sbjct: 909 SRPVRVCRKCFQRLQQ 924
>YNR006w [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 622
Score = 50.1 bits (118), Expect = 4e-06
Identities = 24/64 (37%), Positives = 33/64 (51%), Gaps = 11/64 (17%)
Query: 57 CLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEYEMEPYRTCDS 116
C+ C KFS L R+HHCR CG ++C + N + + P EP R CDS
Sbjct: 176 CMICSKKFSLLNRKHHCRSCGGVFCQE-------HSSNSIPL----PDLGIYEPVRVCDS 224
Query: 117 CYEN 120
C+E+
Sbjct: 225 CFED 228
>Hs14150005 [O] KOG0801 Predicted E3 ubiquitin ligase
Length = 227
Score = 50.1 bits (118), Expect = 4e-06
Identities = 18/34 (52%), Positives = 23/34 (66%)
Query: 260 ECPICFEEMAPGQKVGRLECLCVFHYHCIKSWFK 293
EC IC EE+ G + RL CLC++H CI SWF+
Sbjct: 183 ECVICLEELLQGDTIARLPCLCIYHKSCIDSWFE 216
>Hs13375827 [R] KOG1729 FYVE finger containing protein
Length = 249
Score = 49.7 bits (117), Expect = 6e-06
Identities = 27/75 (36%), Positives = 36/75 (48%), Gaps = 13/75 (17%)
Query: 48 WEKDENVTQCLSCG-IKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVVLKSPAEY 106
W D T C+ C KF+ + RRHHCR CG + C C K + +L S +
Sbjct: 149 WVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEK---------RFLLPSQSS- 198
Query: 107 EMEPYRTCDSCYENL 121
+P R CD CY+ L
Sbjct: 199 --KPVRICDFCYDLL 211
>CE29111 [R] KOG1842 FYVE finger-containing protein
Length = 563
Score = 49.7 bits (117), Expect = 6e-06
Identities = 23/64 (35%), Positives = 30/64 (45%), Gaps = 1/64 (1%)
Query: 40 QFVNEFGEWEKDENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCSKFAWYDKNRVKVV 99
+F E W D C C +F RRHHCR CGR+ C + CSKF +D +
Sbjct: 168 EFEREVVPWLDDAEAVCCPLCASRFGLTRRRHHCRLCGRVLCHS-CSKFLSFDTAKTLTS 226
Query: 100 LKSP 103
+P
Sbjct: 227 SSNP 230
>CE18979 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 1375
Score = 49.3 bits (116), Expect = 8e-06
Identities = 18/36 (50%), Positives = 23/36 (63%)
Query: 51 DENVTQCLSCGIKFSFLVRRHHCRCCGRIYCATCCS 86
D +C C +F+ RRHHCR CG+I+CA CCS
Sbjct: 3 DSTGRECYQCEERFTTFRRRHHCRLCGQIFCAKCCS 38
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.134 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,918,930
Number of Sequences: 60738
Number of extensions: 766313
Number of successful extensions: 2432
Number of sequences better than 1.0e-05: 35
Number of HSP's better than 0.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2383
Number of HSP's gapped (non-prelim): 39
length of query: 326
length of database: 30,389,216
effective HSP length: 107
effective length of query: 219
effective length of database: 23,890,250
effective search space: 5231964750
effective search space used: 5231964750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)