ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3846 good U KOG0929 Intracellular trafficking, secretion, and vesicular transport Guanine nucleotide exchange factor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3846 1356426 1359464 1013
(1013 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPR095c [U] KOG0929 Guanine nucleotide exchange factor 235 2e-61
SPAC26F1.01 [U] KOG0929 Guanine nucleotide exchange factor 90 2e-17
At5g19610 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 81 7e-15
YJR031c [U] KOG0928 Pattern-formation protein/guanine nucleotide... 73 2e-12
At1g13980 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 73 2e-12
At5g39500 [U] KOG0928 Pattern-formation protein/guanine nucleoti... 70 2e-11
CE12328 [U] KOG0931 Predicted guanine nucleotide exchange factor... 69 4e-11
At3g60860 [U] KOG0929 Guanine nucleotide exchange factor 69 5e-11
YEL022w [U] KOG0928 Pattern-formation protein/guanine nucleotide... 68 8e-11
Hs5453573 [U] KOG0929 Guanine nucleotide exchange factor 65 4e-10
Hs5453571 [U] KOG0929 Guanine nucleotide exchange factor 65 4e-10
7298092 [U] KOG0929 Guanine nucleotide exchange factor 64 9e-10
At4g38200 [U] KOG0929 Guanine nucleotide exchange factor 64 1e-09
At4g35380 [U] KOG0929 Guanine nucleotide exchange factor 64 1e-09
YDR170c [U] KOG0929 Guanine nucleotide exchange factor 64 2e-09
At1g01960 [U] KOG0929 Guanine nucleotide exchange factor 63 3e-09
Hs14767357 [U] KOG0931 Predicted guanine nucleotide exchange fac... 62 5e-09
Hs7662290 [U] KOG0931 Predicted guanine nucleotide exchange fact... 60 2e-08
Hs8670544 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 59 4e-08
Hs4758964 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 59 4e-08
7302131 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin... 59 4e-08
SPBC211.03c [U] KOG0928 Pattern-formation protein/guanine nucleo... 59 5e-08
SPAC30.01c [U] KOG0929 Guanine nucleotide exchange factor 59 5e-08
7296387 [U] KOG0931 Predicted guanine nucleotide exchange factor... 58 7e-08
SPAC4D7.01c [U] KOG0929 Guanine nucleotide exchange factor 57 1e-07
Hs4758968 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 56 2e-07
CE24576 [U] KOG0929 Guanine nucleotide exchange factor 56 2e-07
CE29066 [U] KOG0932 Guanine nucleotide exchange factor EFA6 56 3e-07
CE19234 [U] KOG0932 Guanine nucleotide exchange factor EFA6 56 3e-07
Hs7019505 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 55 4e-07
Hs14764245 [U] KOG0931 Predicted guanine nucleotide exchange fac... 54 9e-07
Hs8670546 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 53 2e-06
Hs4758966 [U] KOG0930 Guanine nucleotide exchange factor Cytohes... 53 2e-06
Hs4506161 [U] KOG0932 Guanine nucleotide exchange factor EFA6 53 3e-06
CE26942 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin... 53 3e-06
Hs7662396 [U] KOG0932 Guanine nucleotide exchange factor EFA6 52 4e-06
Hs6912706 [U] KOG0932 Guanine nucleotide exchange factor EFA6 52 4e-06
ECU10g1140 [U] KOG0928 Pattern-formation protein/guanine nucleot... 52 6e-06
>YPR095c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1226
Score = 235 bits (600), Expect = 2e-61
Identities = 168/543 (30%), Positives = 272/543 (49%), Gaps = 82/543 (15%)
Query: 384 SRRSNSLVTTLTNIMSLRSVTGLHS--------QRLSLPTXXXXXXXXXXXXXXXXXXXX 435
SRRS+S+V L++ ++LRS + S Q+L
Sbjct: 405 SRRSSSIVNALSSFVNLRSSSLSSSRQQHLQQQQQLQQKLDVSLEDLPPVPAPEFSDSCK 464
Query: 436 XYLMKIVPVYQKYLALVLCAYEDTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPK 495
+L+K+ P Y K++ ++L +D F +CL + F+F N PLD++LR +L+FLELPK
Sbjct: 465 DFLIKLAP-YGKFIGIILTEKDDEFKKNCLNYLLTNCFEFKNDPLDIALRKLLMFLELPK 523
Query: 496 ESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKE 555
E+QQI+R + FS +YY+ + + + E W + +Q+YF+ +SLLMLHTD FNPNNK
Sbjct: 524 ETQQIDRLIMAFSFAYYKAQKSYSKKKGIECPWSNADQVYFIAFSLLMLHTDYFNPNNKS 583
Query: 556 KITKAEFVKLIHSDTECSGKMVPREYIEYLYENITTKEFPT---TVLPPYDVEESINSQE 612
K+TK +FV L+H+D G +P + Y YEN+T KE P ++ P +++SI ++
Sbjct: 584 KMTKHDFVDLVHNDKYSGGNEIPMAVLTYFYENVTAKESPKFNYFLMSPMALDDSILDKD 643
Query: 613 K-----ALNMIPET-YSPIKIIKSQWLAQRPFLI-------------------------- 640
A+ + + YSPI +IK + + +
Sbjct: 644 AFDTNFAITLSSNSMYSPIDMIKRGSIIPKEASLSPIFYPLTNSISASGIAPSTAASCPP 703
Query: 641 ----------LG----NKNNPATYQ----YSLTPAALPTGTMXXXXXXXXXFAIEDIDPY 682
LG N N PA+ +S P++ +G +DI+ Y
Sbjct: 704 STSGTINGANLGTANSNSNRPASNSISSYFSYNPSSSSSGN--------ATLVQDDINVY 755
Query: 683 HYLINDSLTSITLRNFID-FEPSECLKTS-TEIDTYGAKKLLSLRKEIKGGYLKFNKTQL 740
++IND+L + L + + LK + + + +K S+ + KGGYL+F+K+Q
Sbjct: 756 SHIINDTLNEVNLFPEVSKYWNKNALKANLLRNEEHKYEKYYSIMNDTKGGYLRFHKSQ- 814
Query: 741 LSKFKDINFEILDEDS-----DLQKGYLKVLKMGEI-EMKVSTRKFSLVGNVVKNHWKTK 794
L+K NFEIL+++S + Y K+L+MG I + + +RKFS+V N K HWK +
Sbjct: 815 LNKLNLPNFEILNDNSRSGCKNSDYKYCKILQMGAIMNLGMPSRKFSIV-NSAKIHWKKE 873
Query: 795 FAILTTSFLFFFDSMSWLDPKIELDELTKTSNYIIDLSQPLSSL--YEMEYCNNLFLTEN 852
FAILT+ L D M W++P++ D + T+NYIID S + ++ N LF
Sbjct: 874 FAILTSLGLLICDKMDWINPQMMKDPKSGTTNYIIDFKSGFSFVPGSTIDVYNGLFADRE 933
Query: 853 KNT 855
+++
Sbjct: 934 RDS 936
Score = 69.3 bits (168), Expect = 3e-11
Identities = 43/153 (28%), Positives = 79/153 (51%), Gaps = 14/153 (9%)
Query: 875 NRTEALAWKNSIYFSGSIDGCEIEIAGLRNTFVVQRRTSVEDKILKLKSNHEQNMSKWYS 934
N+ E W +SI + DGC +EI + NT +R+ ++ ++ +L+S K
Sbjct: 1056 NKYERDNWIDSINLFSAYDGCYVEIGSIANTICNKRKLTILQRMERLRSIKSAKWEKLKK 1115
Query: 935 LHSQLNIYLDTVPLSTKTRSNLIDHVNGIIKRIEMVSYQNERLDIYVKLLKLVF--GLEP 992
S L + VP+STKT++++I+ + + R++ + Y+ +R +++V ++K V E
Sbjct: 1116 FESTLMLMGKCVPISTKTKTDMINRIRQLAVRMDWLIYEIKRSELFVSIIKEVTRKQAEK 1175
Query: 993 NPSEYNRYE------------ANSIEESFLFNQ 1013
N E+ + E + IEESFLFN+
Sbjct: 1176 NILEHGKGEEEGQGNNDDSDGIDDIEESFLFNE 1208
>SPAC26F1.01 [U] KOG0929 Guanine nucleotide exchange factor
Length = 657
Score = 90.1 bits (222), Expect = 2e-17
Identities = 138/604 (22%), Positives = 236/604 (38%), Gaps = 120/604 (19%)
Query: 446 QKYLALVLCAYEDTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLK 505
+++ +L + L CL++++ +F LD++LR L LP E+QQI+R L
Sbjct: 19 KQFTPAILSQGTSSLLKLCLRKYLSV-VNFKCISLDMALRKFLAVYVLPNETQQIDRVLS 77
Query: 506 CFSVSYYRQHCNAERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKL 565
FS Y+ HCN + ++S+ + Y LT+SL++LHTD FN +N++K+T+AEF+
Sbjct: 78 TFSDQYF--HCNPDLYDSSD-------ECYILTFSLMILHTDFFNIHNRQKMTRAEFISN 128
Query: 566 IHSDTECSGKMVPREYIEYLYENITTKEFPTTVLPPYDVEESINSQEKALNMIPETYSPI 625
+ T + E +E Y+NIT F VE + + + S
Sbjct: 129 TNLPT------ILPEILECFYDNITYTPF-------VHVEH--------IGCVVTSPSNE 167
Query: 626 KIIKSQWLAQRPFLILGNKNNPATYQYSLTPAALPTGTMXXXXXXXXXFAIEDIDPYHYL 685
K SQ L F L +N AT + H
Sbjct: 168 KPSLSQRLGDSQFR-LTKRNTFAT------------------------------ESDHQA 196
Query: 686 INDSLTS--ITLRNFIDFEPSECLKTSTEIDTYGAKKLLSLRKEIKGGYLKFNKTQLLSK 743
+ + LT I L + +D + + ++TS E T A L ++ + +L+ + +
Sbjct: 197 LQEQLTGFRINLDSILDLKKIDSVRTSIESPTRTADDL--YKEFARAPFLQIVSHRSQPQ 254
Query: 744 FKDINFEILDEDSDLQKGYL--KVLKMGEIEMKVSTRKFSLVGNVVKNHWKTKFAILTTS 801
+FE E + KV K+G + RK L+ N + ILT+S
Sbjct: 255 AFSYHFEPSAESESTNPAIINVKVFKLGILIQNEKVRKDRLLSN------REVGVILTSS 308
Query: 802 FLFFFDSMSWLDPKIELDELTKTS-----------------NYIIDLSQPLSSLYEMEYC 844
L FF ++ W+ ++ E K S +YII LS ++
Sbjct: 309 QLMFFKNVYWISGLLDQLEDFKRSHSFSPCYFSPHLTSLSADYIIPLSDLVAYGDGSRIE 368
Query: 845 NNL--FLTENKNTDPNVLSIVNQSQKRDIMFRNR------TEALAWKNSIYFSGSID-GC 895
N L F + KN +V S+ N + D + + T LA + + S D
Sbjct: 369 NELYSFSVKQKNQRTHVFSVTNVDELNDWLVKINFVSTFATAGLAPRERLPCVESSDKSI 428
Query: 896 EIEIAGLRNTFVVQRRTS--------------------VEDKILKLKSNHEQNMSKWYSL 935
+ ++ L + + S V+++I KL+ Q SK
Sbjct: 429 KASVSVLPDIYEDSDAMSKASKETRSEVLECSKVRVYIVQNRIYKLEEALRQGESKMTVQ 488
Query: 936 HSQLNIYLDTVPLSTKTRSNLIDHVNGIIKRIEMVSYQNERLDIYVKLLKLVFGLEPNPS 995
L P+ ++TR L N + K + + ++ I +K LK ++ +
Sbjct: 489 RRNAANILHLEPIQSRTRIRLARCSNTLKKNMLAQMIEIQKFKISIKFLKEDLEMDSHLQ 548
Query: 996 EYNR 999
+Y R
Sbjct: 549 DYLR 552
>At5g19610 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1375
Score = 81.3 bits (199), Expect = 7e-15
Identities = 49/137 (35%), Positives = 77/137 (55%), Gaps = 11/137 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D LS L+ F F+F+ LD +LRT L LP ESQ+IER ++ FS +Y Q
Sbjct: 553 DELHLSVLRSFTHT-FEFTGMNLDTALRTFLESFRLPGESQKIERMIEAFSERFYDQ--- 608
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
S I+ + ++ L YSL+ML+TD NP + K+T+ EF++ ++ +G +
Sbjct: 609 -----QSSDIFASKDTVHILCYSLIMLNTDQHNPQVRRKMTEDEFIR--NNRAINAGNDL 661
Query: 578 PREYIEYLYENITTKEF 594
P+EY+ L+++I T F
Sbjct: 662 PKEYLSELFQSIATNAF 678
>YJR031c [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1408
Score = 73.2 bits (178), Expect = 2e-12
Identities = 52/166 (31%), Positives = 86/166 (51%), Gaps = 26/166 (15%)
Query: 446 QKYLALVLCAYEDTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLK 505
+K + L+LC + T S L++F+D FDF +D ++R +L LP ESQQIER ++
Sbjct: 590 KKTIGLLLCDPKKT---SLLKEFIDL-FDFKGLRVDEAIRILLTKFRLPGESQQIERIVE 645
Query: 506 CFSVSYYRQHCNAERIENSEP-----------------IWKDIEQLYFLTYSLLMLHTDS 548
FS Y N +++E + + D + ++ L+YS++ML+TDS
Sbjct: 646 AFSSKYSADQSN-DKVELEDKKAGKNGSESMTEDDIIHVQPDADSVFVLSYSIIMLNTDS 704
Query: 549 FNPNNKEKITKAEFVKLIHSDTEC-SGKMVPREYIEYLYENITTKE 593
NP K+ +T ++ + C +GK PR Y+ +Y +I KE
Sbjct: 705 HNPQVKDHMTFDDYSNNLRG---CYNGKDFPRWYLHKIYTSIKVKE 747
>At1g13980 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1451
Score = 73.2 bits (178), Expect = 2e-12
Identities = 48/140 (34%), Positives = 73/140 (51%), Gaps = 12/140 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D F + L +F FDF LD +LR L LP ESQ+I+R L+ FS YY Q
Sbjct: 621 DEFCVQVLNEFAGT-FDFQYMNLDTALRLFLETFRLPGESQKIQRVLEAFSERYYMQ--- 676
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
S I + + L+YS++ML+TD N K+K+T+ +F++ ++ G +
Sbjct: 677 ------SPEILANKDAALVLSYSIIMLNTDQHNVQVKKKMTEEDFIR--NNRHINGGNDL 728
Query: 578 PREYIEYLYENITTKEFPTT 597
PRE++ L+ +I E TT
Sbjct: 729 PREFLSELFHSICNNEIRTT 748
>At5g39500 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1443
Score = 70.1 bits (170), Expect = 2e-11
Identities = 45/136 (33%), Positives = 71/136 (52%), Gaps = 12/136 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D F + L +F K FDF N L +LR + +L E+Q+I R L+ FS YY
Sbjct: 621 DQFCIQVLHEFA-KTFDFQNMNLATALRLFVGTFKLSGEAQKIHRVLEAFSERYY----- 674
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
E S I D + + L YS+++L+TD N K ++T+ +F++ ++ T G +
Sbjct: 675 ----EQSPHILIDKDAAFVLAYSIILLNTDQHNAQVKTRMTEEDFIR--NNRTINGGADL 728
Query: 578 PREYIEYLYENITTKE 593
PREY+ +Y +I E
Sbjct: 729 PREYLSEIYHSIRHSE 744
>CE12328 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 614
Score = 68.9 bits (167), Expect = 4e-11
Identities = 37/135 (27%), Positives = 78/135 (57%), Gaps = 9/135 (6%)
Query: 463 SCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIE 522
S + ++ D +D++LR + F LPKE+++I+R ++ F++ Y + N +R
Sbjct: 261 SLVLKYFTALIDIRGLEVDVALRKAMQFFILPKEAEKIDRIIQAFALHYSKS--NPKRTS 318
Query: 523 NSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKM----VP 578
+ W + ++ L+++++ML+TD +PN K+++T+A+FVK + + SG+ +
Sbjct: 319 HYRGGW---DTIHLLSFAIIMLNTDLHSPNVKQRMTQADFVKNLRGQDKISGEKNGEDID 375
Query: 579 REYIEYLYENITTKE 593
R+ +E +Y+ I E
Sbjct: 376 RKTLEGIYDRIKKDE 390
>At3g60860 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1793
Score = 68.6 bits (166), Expect = 5e-11
Identities = 42/132 (31%), Positives = 72/132 (53%), Gaps = 12/132 (9%)
Query: 462 LSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERI 521
L + ++D FDF D ++RT L LP E+Q+I+R ++ F+ Y + CN +
Sbjct: 679 LKVMHAYVDS-FDFRGMEFDEAIRTFLEGFRLPGEAQKIDRIMEKFAERYCK--CNPK-- 733
Query: 522 ENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREY 581
++ + Y L YS++ML+TD+ NP K K++ +F++ ++ GK +P +Y
Sbjct: 734 -----VFTSADSAYVLAYSVIMLNTDAHNPMVKNKMSADDFIR--NNRGIDDGKDLPADY 786
Query: 582 IEYLYENITTKE 593
+ LYE IT E
Sbjct: 787 MRSLYERITKHE 798
>YEL022w [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1459
Score = 67.8 bits (164), Expect = 8e-11
Identities = 49/154 (31%), Positives = 87/154 (55%), Gaps = 12/154 (7%)
Query: 446 QKYLALVLCAYEDTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLK 505
+K + L+LC + +S L +++ + FDFS +D ++R +L LP ESQQIER ++
Sbjct: 608 KKTIGLLLCHPDK---VSLLNEYI-RLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIE 663
Query: 506 CFSVSY-YRQHCNAERI-ENSE----PIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITK 559
FS +Y Q + +I +N+E + D + ++ L+YS++ML+TD NP KE ++
Sbjct: 664 AFSSAYCENQDYDPSKISDNAEDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKEHMSF 723
Query: 560 AEFVKLIHSDTECSGKMVPREYIEYLYENITTKE 593
++ + C+ K P Y++ +Y +I KE
Sbjct: 724 EDYSGNLKGC--CNHKDFPFWYLDRIYCSIRDKE 755
>Hs5453573 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1785
Score = 65.5 bits (158), Expect = 4e-10
Identities = 38/122 (31%), Positives = 64/122 (52%), Gaps = 9/122 (7%)
Query: 472 EFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDI 531
+ DF + +LRT L LP E+Q+I+R ++ F+ Y CN + ++
Sbjct: 714 QLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIE--CN-----QGQTLFASA 766
Query: 532 EQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENITT 591
+ Y L YS++ML TD +P K K+TK +++K+ + K +P EY+ +YE I
Sbjct: 767 DTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGIND--SKDLPEEYLSSIYEEIEG 824
Query: 592 KE 593
K+
Sbjct: 825 KK 826
>Hs5453571 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1849
Score = 65.5 bits (158), Expect = 4e-10
Identities = 43/161 (26%), Positives = 81/161 (49%), Gaps = 15/161 (9%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D F + ++D+ DFS + +LR L LP E+Q+I+R ++ F+ Y CN
Sbjct: 756 DKFNKEVMYAYVDQH-DFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLE--CN 812
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+ ++ + Y L YS++ML TD +P K K+TK +++K+ + K +
Sbjct: 813 -----QGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGIND--SKDL 865
Query: 578 PREYIEYLY-----ENITTKEFPTTVLPPYDVEESINSQEK 613
P EY+ +Y + I+ KE +P ++++ S+++
Sbjct: 866 PEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQNVASEKQ 906
>7298092 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1643
Score = 64.3 bits (155), Expect = 9e-10
Identities = 41/142 (28%), Positives = 73/142 (50%), Gaps = 21/142 (14%)
Query: 452 VLCAYEDTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSY 511
V+CAY D F DF + +LR +L LP E+Q+I+R ++ F+ Y
Sbjct: 636 VMCAYIDAF-------------DFRQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRY 682
Query: 512 YRQHCNAERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTE 571
CN + +++ + +Y L +S++ML TD +P K K+TK +++K+ ++
Sbjct: 683 CE--CNPKN-----QLFQSADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISD 735
Query: 572 CSGKMVPREYIEYLYENITTKE 593
S +P EY+ +Y+ I+ E
Sbjct: 736 -SKSDLPEEYLSSIYDEISEHE 756
>At4g38200 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1698
Score = 63.9 bits (154), Expect = 1e-09
Identities = 40/136 (29%), Positives = 72/136 (52%), Gaps = 12/136 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
+ F + + ++D FDF ++R L LP E+Q+I+R ++ F+ + + CN
Sbjct: 608 EDFPMKVMHAYVDS-FDFKEMNFGEAIRFFLRGFRLPGEAQKIDRIMEKFAERFCK--CN 664
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+++ Y L YS++ML+TD+ N KEK+TKA+F++ ++ GK +
Sbjct: 665 PNSFSSADTA-------YVLAYSVIMLNTDAHNIMVKEKMTKADFIR--NNRGIDDGKDL 715
Query: 578 PREYIEYLYENITTKE 593
P EY+ LY+ + E
Sbjct: 716 PEEYLGALYDQVVINE 731
>At4g35380 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1711
Score = 63.9 bits (154), Expect = 1e-09
Identities = 41/136 (30%), Positives = 74/136 (54%), Gaps = 12/136 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D L + ++D F+F + ++R L LP E+Q+I+R ++ F+ Y++ CN
Sbjct: 625 DELPLKVMHAYVDS-FNFEKKDFVEAIRFFLRGFRLPGEAQKIDRIMEKFAEHYWK--CN 681
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+++ Y L YS++ML+TD+ N K+K+TKA+FV+ ++ GK +
Sbjct: 682 PGSFTSADTA-------YVLAYSVIMLNTDAHNNMVKDKMTKADFVR--NNRGIDDGKDL 732
Query: 578 PREYIEYLYENITTKE 593
P EY+ LY+ + +E
Sbjct: 733 PEEYLGSLYDRVVKEE 748
>YDR170c [U] KOG0929 Guanine nucleotide exchange factor
Length = 2009
Score = 63.5 bits (153), Expect = 2e-09
Identities = 41/133 (30%), Positives = 74/133 (54%), Gaps = 14/133 (10%)
Query: 462 LSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERI 521
++ + F+D EFDF+ + +LR+ L LP E Q+I+RF+ F AER
Sbjct: 890 IAIMHAFVD-EFDFTGMSIVDALRSFLQSFRLPGEGQKIDRFMLKF----------AERF 938
Query: 522 ENSEP-IWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPRE 580
+ P ++ + Y L+YSL+ML+TD + K K++ EF++ +++ +G+ +PR+
Sbjct: 939 VDQNPGVFSKADTAYVLSYSLIMLNTDLHSSQIKNKMSLQEFLE--NNEGIDNGRDLPRD 996
Query: 581 YIEYLYENITTKE 593
++E L+ I E
Sbjct: 997 FLEGLFNEIANNE 1009
>At1g01960 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1750
Score = 62.8 bits (151), Expect = 3e-09
Identities = 39/132 (29%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 462 LSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERI 521
L + ++D F+F D ++R L LP E+Q+I+R ++ F+ + + CN +
Sbjct: 670 LKVMHAYVDS-FEFQGMEFDEAIRAFLRGFRLPGEAQKIDRIMEKFAERFCK--CNPKDF 726
Query: 522 ENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREY 581
+++ Y L YS+++L+TD+ NP K K+T F++ ++ GK +P EY
Sbjct: 727 SSADTA-------YVLAYSVILLNTDAHNPMVKSKMTADGFIR--NNRGIDDGKDLPEEY 777
Query: 582 IEYLYENITTKE 593
+ LYE I+ E
Sbjct: 778 LRALYERISRNE 789
>Hs14767357 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 701
Score = 62.0 bits (149), Expect = 5e-09
Identities = 42/151 (27%), Positives = 80/151 (52%), Gaps = 13/151 (8%)
Query: 472 EFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDI 531
E DFS+ LD +LR + + E+Q++ER ++ FS Y CN E ++ + +
Sbjct: 242 EMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCM--CNPEVVQQ----FHNP 295
Query: 532 EQLYFLTYSLLMLHTDSFNPNNK--EKITKAEFVKLIHSDTECSGKMVPREYIEYLYENI 589
+ ++ L +++++L+TD ++PN K K+ +F++ + + G +PRE + +YE I
Sbjct: 296 DTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDD--GADIPRELVVGIYERI 353
Query: 590 TTKEFPTT---VLPPYDVEESINSQEKALNM 617
KE + V VE+SI + L++
Sbjct: 354 QQKELKSNEDHVTYVTKVEKSIVGMKTVLSV 384
>Hs7662290 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 841
Score = 59.7 bits (143), Expect = 2e-08
Identities = 36/127 (28%), Positives = 69/127 (53%), Gaps = 10/127 (7%)
Query: 472 EFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDI 531
E DFS LD +LR + + E+Q++ER ++ FS Y CN + +++
Sbjct: 474 EMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYC--ICNPGVVRQ----FRNP 527
Query: 532 EQLYFLTYSLLMLHTDSFNPNNK--EKITKAEFVKLIHSDTECSGKMVPREYIEYLYENI 589
+ ++ L +++++L+TD ++PN K K+ +F+K + + G+ +PRE + +YE I
Sbjct: 528 DTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDD--GEDIPREMLMGIYERI 585
Query: 590 TTKEFPT 596
+E T
Sbjct: 586 RKRELKT 592
>Hs8670544 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 397
Score = 58.9 bits (141), Expect = 4e-08
Identities = 39/137 (28%), Positives = 71/137 (51%), Gaps = 12/137 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D F + L F++ +F++ L +LR L LP E+Q+I+R ++ F+ Y + CN
Sbjct: 120 DEFNIQVLHAFVELH-EFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQ--CN 176
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+++ + Y L+++++ML+T NPN K+K T F+ + + G +
Sbjct: 177 -------NGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGIND--GGDL 227
Query: 578 PREYIEYLYENITTKEF 594
P E + LYE+I + F
Sbjct: 228 PEELLRNLYESIKNEPF 244
>Hs4758964 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 398
Score = 58.9 bits (141), Expect = 4e-08
Identities = 39/137 (28%), Positives = 71/137 (51%), Gaps = 12/137 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D F + L F++ +F++ L +LR L LP E+Q+I+R ++ F+ Y + CN
Sbjct: 120 DEFNIQVLHAFVELH-EFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQ--CN 176
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+++ + Y L+++++ML+T NPN K+K T F+ + + G +
Sbjct: 177 -------NGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGIND--GGDL 227
Query: 578 PREYIEYLYENITTKEF 594
P E + LYE+I + F
Sbjct: 228 PEELLRNLYESIKNEPF 244
>7302131 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 348
Score = 58.9 bits (141), Expect = 4e-08
Identities = 37/121 (30%), Positives = 66/121 (53%), Gaps = 11/121 (9%)
Query: 474 DFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDIEQ 533
DF+N L +LR L LP E+Q+I+R ++ F+ Y + + I+ + +
Sbjct: 88 DFTNLILVQALRQFLWSFRLPGEAQKIDRMMETFAQRY---------CQLNPDIFTNTDT 138
Query: 534 LYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENITTKE 593
Y L+++++ML+T NP+ K+K T +F+ + +G +PR +E LYE+I T+
Sbjct: 139 CYVLSFAIIMLNTSLHNPSVKDKPTVDQFISMNRGIN--NGGDLPRGLLESLYESIRTEP 196
Query: 594 F 594
F
Sbjct: 197 F 197
>SPBC211.03c [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1462
Score = 58.5 bits (140), Expect = 5e-08
Identities = 42/137 (30%), Positives = 71/137 (51%), Gaps = 15/137 (10%)
Query: 473 FDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDIE 532
FDF + +D +LR +L LP ESQ IER L+ F S+Y N + + + +
Sbjct: 620 FDFKGKRIDEALRLLLQSFRLPGESQLIERVLETF--SHYYMSANPDSMSSK-------D 670
Query: 533 QLYFLTYSLLMLHTDSFNPN--NKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENIT 590
+ L+YS++ML+TD NPN ++ ++T +F + + + G+ R ++ +Y+ I
Sbjct: 671 AAFVLSYSIIMLNTDQHNPNIKSQRRMTLDDFCRNVRGVND--GQDFDRNFLSEIYKAI- 727
Query: 591 TKEFPTTVLPPYDVEES 607
KE V +D E S
Sbjct: 728 -KENEIIVAEEHDTELS 743
>SPAC30.01c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1822
Score = 58.5 bits (140), Expect = 5e-08
Identities = 37/132 (28%), Positives = 70/132 (53%), Gaps = 12/132 (9%)
Query: 462 LSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERI 521
+S + +F+D F N +LR +L LP E+Q+I+R + FS Y +++ +A
Sbjct: 771 ISVMHEFIDC-LSFINLKFVDALRRLLQCFRLPGEAQKIDRIMLKFSERYMKENPSA--- 826
Query: 522 ENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREY 581
+ + + Y L YS+++L+TD +P K K+TK +F+K + G + +Y
Sbjct: 827 ------FANADTAYILAYSIILLNTDLHSPRIKNKMTKEDFIKNNRGIND--GADLDEDY 878
Query: 582 IEYLYENITTKE 593
+ ++Y++I E
Sbjct: 879 LGFVYDDILKNE 890
>7296387 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 1210
Score = 58.2 bits (139), Expect = 7e-08
Identities = 38/139 (27%), Positives = 73/139 (52%), Gaps = 20/139 (14%)
Query: 461 LLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAE- 519
+LSC E D S + +D++LR + +P E+Q+IER ++ FS Y CNA+
Sbjct: 716 VLSCFAM----ELDLSGRQVDVALRKFQAYFRMPGEAQKIERLMEIFSQRYC--ECNADI 769
Query: 520 --RIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNK--EKITKAEFVKLIHSDTECSGK 575
R+ +S+ I + L ++++ML+TD PN K ++ +F+K + +C
Sbjct: 770 VGRLRSSDTI-------FVLAFAIIMLNTDLHTPNLKPERRMRVEDFIKNLRGIDDCHD- 821
Query: 576 MVPREYIEYLYENITTKEF 594
+ ++ + +Y+ + + EF
Sbjct: 822 -IDKDMLMGIYDRVKSDEF 839
>SPAC4D7.01c [U] KOG0929 Guanine nucleotide exchange factor
Length = 1811
Score = 57.0 bits (136), Expect = 1e-07
Identities = 36/132 (27%), Positives = 70/132 (52%), Gaps = 12/132 (9%)
Query: 462 LSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERI 521
++ + F+D F++ P +LR+ L LP E+Q+I+RF+ F+ Y I
Sbjct: 762 IAIMHSFVD-HMSFNDIPFVNALRSFLQKFRLPGEAQKIDRFMLKFAEKY---------I 811
Query: 522 ENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREY 581
+++ ++K+ + Y L YS++ML+TD +P K ++T +F+K ++ G + +
Sbjct: 812 DDNLGVFKNADTAYILAYSIIMLNTDLHSPQVKNRMTCQDFIK--NNRGVDDGANLSDSF 869
Query: 582 IEYLYENITTKE 593
+ +YE I E
Sbjct: 870 LTEVYEEIQKNE 881
>Hs4758968 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 399
Score = 56.2 bits (134), Expect = 2e-07
Identities = 39/137 (28%), Positives = 70/137 (50%), Gaps = 12/137 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D F + LQ F++ +F++ L +LR L LP E+Q+I+R ++ F+ Y CN
Sbjct: 124 DEFNIKVLQAFVELH-EFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCL--CN 180
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+++ + Y L+++++ML+T N N ++K T F+ + E G +
Sbjct: 181 -------PGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINE--GGDL 231
Query: 578 PREYIEYLYENITTKEF 594
P E + LYE+I + F
Sbjct: 232 PEELLRNLYESIKNEPF 248
>CE24576 [U] KOG0929 Guanine nucleotide exchange factor
Length = 1628
Score = 56.2 bits (134), Expect = 2e-07
Identities = 41/136 (30%), Positives = 68/136 (49%), Gaps = 10/136 (7%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D F S + ++D DFS+ + +LR L LP E+Q+I+R + F+ Y CN
Sbjct: 571 DEFNNSVMHAYIDF-LDFSSIDILAALRMFLEKFRLPGEAQKIDRLMLKFASRYL--DCN 627
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+ I+ + Y L +S++ML TD N K K+TK ++ + E G +
Sbjct: 628 PR-----QGIFASADAAYVLAFSIIMLTTDLHNKTVKNKMTKQGYINMNRGINE--GGNI 680
Query: 578 PREYIEYLYENITTKE 593
P E +E ++E+I+ E
Sbjct: 681 PVELLEAIFEDISKNE 696
>CE29066 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 818
Score = 55.8 bits (133), Expect = 3e-07
Identities = 38/117 (32%), Positives = 65/117 (55%), Gaps = 13/117 (11%)
Query: 473 FDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDIE 532
F FS +D +LR L +EL ES ER L+ FS Y +E + I+ ++
Sbjct: 426 FQFSTTRIDAALREFLSRVELRGESSARERLLRVFSARY---------LECNPAIFDSLD 476
Query: 533 QLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENI 589
+++ LT +LL+L++D PN +K+T +F+ I + T C+ K RE ++ L+++I
Sbjct: 477 EVHTLTCALLLLNSDLHGPNMGKKMTARDFITNI-AHTGCTFK---REMLKTLFQSI 529
>CE19234 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 816
Score = 55.8 bits (133), Expect = 3e-07
Identities = 38/117 (32%), Positives = 65/117 (55%), Gaps = 13/117 (11%)
Query: 473 FDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDIE 532
F FS +D +LR L +EL ES ER L+ FS Y +E + I+ ++
Sbjct: 424 FQFSTTRIDAALREFLSRVELRGESSARERLLRVFSARY---------LECNPAIFDSLD 474
Query: 533 QLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENI 589
+++ LT +LL+L++D PN +K+T +F+ I + T C+ K RE ++ L+++I
Sbjct: 475 EVHTLTCALLLLNSDLHGPNMGKKMTARDFITNI-AHTGCTFK---REMLKTLFQSI 527
>Hs7019505 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 394
Score = 55.5 bits (132), Expect = 4e-07
Identities = 38/137 (27%), Positives = 70/137 (50%), Gaps = 12/137 (8%)
Query: 458 DTFLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCN 517
D L LQ F+D +F+N L +LR L LP E+Q+I+R ++ F+ Y CN
Sbjct: 119 DPINLQVLQAFVDCH-EFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCL--CN 175
Query: 518 AERIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMV 577
+++ + Y L++S++ML+T NPN +++ FV + +G +
Sbjct: 176 -------PGVFQSTDTCYVLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGIN--NGSDL 226
Query: 578 PREYIEYLYENITTKEF 594
P + + L+++I ++ F
Sbjct: 227 PEDQLRNLFDSIKSEPF 243
>Hs14764245 [U] KOG0931 Predicted guanine nucleotide exchange factor contains
Sec7 domain
Length = 1488
Score = 54.3 bits (129), Expect = 9e-07
Identities = 33/127 (25%), Positives = 70/127 (54%), Gaps = 10/127 (7%)
Query: 472 EFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDI 531
E DFS+ LD +LR + + E+Q++ER ++ FS Y CN + +++
Sbjct: 825 EMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYC--VCNPALVRQ----FRNP 878
Query: 532 EQLYFLTYSLLMLHTDSFNPNNK--EKITKAEFVKLIHSDTECSGKMVPREYIEYLYENI 589
+ ++ L +++++L+TD ++P+ K K+ +F+K + +G+ +PR+ + +Y+ I
Sbjct: 879 DTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVD--NGEDIPRDLLVGIYQRI 936
Query: 590 TTKEFPT 596
+E T
Sbjct: 937 QGRELRT 943
>Hs8670546 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 400
Score = 53.1 bits (126), Expect = 2e-06
Identities = 38/133 (28%), Positives = 68/133 (50%), Gaps = 12/133 (9%)
Query: 462 LSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERI 521
L+ L F+D +F++ L +LR L LP E+Q+I+R ++ F+ Y CN
Sbjct: 123 LAVLHAFVDLH-EFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCL--CNPG-- 177
Query: 522 ENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREY 581
+++ + Y L+++++ML+T NPN ++K FV + E G +P E
Sbjct: 178 -----VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINE--GGDLPEEL 230
Query: 582 IEYLYENITTKEF 594
+ LY++I + F
Sbjct: 231 LRNLYDSIRNEPF 243
>Hs4758966 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 399
Score = 53.1 bits (126), Expect = 2e-06
Identities = 38/133 (28%), Positives = 68/133 (50%), Gaps = 12/133 (9%)
Query: 462 LSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERI 521
L+ L F+D +F++ L +LR L LP E+Q+I+R ++ F+ Y CN
Sbjct: 123 LAVLHAFVDLH-EFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCL--CNPG-- 177
Query: 522 ENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREY 581
+++ + Y L+++++ML+T NPN ++K FV + E G +P E
Sbjct: 178 -----VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINE--GGDLPEEL 230
Query: 582 IEYLYENITTKEF 594
+ LY++I + F
Sbjct: 231 LRNLYDSIRNEPF 243
>Hs4506161 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 645
Score = 52.8 bits (125), Expect = 3e-06
Identities = 49/182 (26%), Positives = 83/182 (44%), Gaps = 17/182 (9%)
Query: 471 KEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKD 530
K F F+ LD +LR L L L E+Q+ ER L FS Y++ CN E + +
Sbjct: 217 KFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQ--CNPEALSSE------ 268
Query: 531 IEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENIT 590
+ + LT +L++L+TD N +++T +F+ + + G PRE ++ LY +I
Sbjct: 269 -DGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLND--GGDFPRELLKALYSSIK 325
Query: 591 TKEFPTTVLPPYDVEESINSQEKALNMIPETYSPIKIIKSQWLAQRPFLILGNKNNPATY 650
++ + D EE S + + P+ +I PFL L + A Y
Sbjct: 326 NEKLQWAI----DEEELRRSLSELADPNPKVIK--RISGGSGSGSSPFLDLTPEPGAAVY 379
Query: 651 QY 652
++
Sbjct: 380 KH 381
>CE26942 [U] KOG0930 Guanine nucleotide exchange factor Cytohesin contains
PH and Sec7 domains
Length = 393
Score = 52.8 bits (125), Expect = 3e-06
Identities = 38/135 (28%), Positives = 66/135 (48%), Gaps = 13/135 (9%)
Query: 460 FLLSCLQQFMDKEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAE 519
F L L +F KE + P+ +LR L LP ESQ+I R L+ F AE
Sbjct: 120 FALETLDRFT-KEHKLHDVPIVPALRQYLFSFRLPGESQKINRILEKF----------AE 168
Query: 520 RIENSEPIWKDIEQLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPR 579
N P + + +Q + + YS +M++T NPN K+K + +++++ E +
Sbjct: 169 VYANQNPSYGNADQAHTVAYSCIMVNTLLHNPNVKDKPSLEKYIEMNEQLLEKGA--ITI 226
Query: 580 EYIEYLYENITTKEF 594
E + +YE+++ +F
Sbjct: 227 EQLTEVYESVSVTQF 241
>Hs7662396 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 534
Score = 52.4 bits (124), Expect = 4e-06
Identities = 54/187 (28%), Positives = 88/187 (46%), Gaps = 27/187 (14%)
Query: 471 KEFDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKD 530
K FDF+ LD SLR L E+Q+ ER L FS Y+ +CN + I + + +
Sbjct: 109 KFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHFSNRYF--YCNPDTIASQDGV--- 163
Query: 531 IEQLYFLTYSLLMLHTDSF-NPNNKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENI 589
+ LT ++++L+TD + N +K+T EF+ + E G ++ ++ LY +I
Sbjct: 164 ----HCLTCAIMLLNTDLHGHVNIGKKMTCQEFIANLQGVNE--GVDFSKDLLKALYNSI 217
Query: 590 TTKEFPTTVLPPYDVEE-----SINSQEKALNMIPETYSPIKIIKSQWLAQRPFLILGNK 644
++ V D EE S +++EKA P+T S I PFL + +
Sbjct: 218 KNEKLEWAV----DDEEKKKSPSESTEEKANGTHPKTISRI------GSTTNPFLDIPHD 267
Query: 645 NNPATYQ 651
N A Y+
Sbjct: 268 PNAAVYK 274
>Hs6912706 [U] KOG0932 Guanine nucleotide exchange factor EFA6
Length = 1056
Score = 52.4 bits (124), Expect = 4e-06
Identities = 42/147 (28%), Positives = 73/147 (49%), Gaps = 16/147 (10%)
Query: 473 FDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDIE 532
F F Q LD +LR+ L L L E+Q+ ER L FS ++ HCN I+ ++
Sbjct: 628 FQFGGQSLDRALRSFLQALVLSGETQERERILYQFSRRFH--HCN-------PGIFPSVD 678
Query: 533 QLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVPREYIEYLYENITTK 592
++ LT ++++L+TD N + ++ EF+ ++ + G P+E ++ LY +I ++
Sbjct: 679 SVHTLTCAIMLLNTDLHGQNIGKSMSCQEFITNLNGLRD--GGNFPKELLKALYWSIRSE 736
Query: 593 EFPTTVLPPYDVEESINSQEKALNMIP 619
+ V EE EKA +P
Sbjct: 737 KLEWAV-----DEEDTARPEKAQPSLP 758
>ECU10g1140 [U] KOG0928 Pattern-formation protein/guanine nucleotide exchange
factor
Length = 1063
Score = 51.6 bits (122), Expect = 6e-06
Identities = 37/129 (28%), Positives = 65/129 (49%), Gaps = 12/129 (9%)
Query: 473 FDFSNQPLDLSLRTVLLFLELPKESQQIERFLKCFSVSYYRQHCNAERIENSEPIWKDIE 532
FDF + + LRT LL L E Q I R ++ ++ YY + +A + + E
Sbjct: 362 FDFLDMDILDGLRTYLLSFHLSAEGQIIHRVVEAYADKYYSDNVDACTFMDITRDKRTKE 421
Query: 533 QLYFLTYSLLMLHTDSFNPNNKEKITKAEFVKLIHSDTECSGKMVP----REYIEYLYEN 588
++ L +S L+L+T NPN K K T +++K + + + +P EY+E +Y++
Sbjct: 422 FVFNLAFSFLVLNTKFHNPNVKAKPTFRDYMK------DFTAEEIPPSFSEEYLESMYQS 475
Query: 589 ITTK--EFP 595
+ + EFP
Sbjct: 476 VKKRPLEFP 484
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.132 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,626,559
Number of Sequences: 60738
Number of extensions: 2328146
Number of successful extensions: 7001
Number of sequences better than 1.0e-05: 38
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 6928
Number of HSP's gapped (non-prelim): 64
length of query: 1013
length of database: 30,389,216
effective HSP length: 116
effective length of query: 897
effective length of database: 23,343,608
effective search space: 20939216376
effective search space used: 20939216376
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)