ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3855 good W KOG1747 Extracellular structures Protein tyrosine kinase 9/actin monomer-binding protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3855 1362275 1361331 -315
(315 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR080w [W] KOG1747 Protein tyrosine kinase 9/actin monomer-bind... 144 1e-34
SPCC126.06 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-b... 83 6e-16
Hs6005846 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-bi... 77 3e-14
Hs4506275 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-bi... 70 5e-12
7299845 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-bind... 68 2e-11
CE28307 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-bind... 62 1e-09
CE20549 [Z] KOG1735 Actin depolymerizing factor 50 6e-06
CE20548 [Z] KOG1735 Actin depolymerizing factor 50 6e-06
>YGR080w [W] KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein
Length = 332
Score = 144 bits (364), Expect = 1e-34
Identities = 101/302 (33%), Positives = 159/302 (52%), Gaps = 25/302 (8%)
Query: 1 MSNQSGIIADQEVLNAIAELPTR--YASVVAKIEQTDEPVIKLHDTFHDLDALREF---- 54
MS QSGI+A+Q +L+++ E + ++AKI V H R F
Sbjct: 1 MSTQSGIVAEQALLHSLNENLSADGIVIIIAKISPDSTSV-------HQTQVARSFEELV 53
Query: 55 -IDGNEDTPYYIIIHDD--PKSIFIAYTPDYAPIRSKMLYASSKIAFQRQIGANNLKSF- 110
+ E P YI + K F+++ PD +P+RS+MLYAS+K RQ+G+N+L +
Sbjct: 54 QLASQEREPLYIFYKPEGLDKYFFVSFIPDGSPVRSRMLYASTKNTLARQVGSNSLSTEQ 113
Query: 111 -MFTEPGDIDEKSWTDST---AREELMTESELEKLQIDAQQHTMRNSGAVKLVSAHNSTA 166
+ T+ D+ + DS + + +T E +++I+ QQ +R + +VKLVS +++
Sbjct: 114 PLITDAQDLVDLKNFDSARPAGQNKPLTHDEEMQIEINKQQALLRKNTSVKLVSQDSASP 173
Query: 167 NTLGFKVVDTGNIKPLL--EKYNLLVFKIDLGTEEIKIKNKINTSYSAEIIERISSDSPS 224
+L F+V I +L E NL++F+ID E I+I E+ I PS
Sbjct: 174 LSLTFRVNSEKPINEILDSEGKNLIIFQIDPSNETIQIVQSDTCPSVDELY--IDLPGPS 231
Query: 225 YCIFHKSGNYYFILTCPSGSAIKERMVYAANKRAFLISLKDSDDIEIKRTFEIGDSDELD 284
Y IF + + +FI +CPSGS +K+RM+YA+NK F+ LK+ I + EIGD ELD
Sbjct: 232 YTIFRQGDSSFFIYSCPSGSKVKDRMIYASNKNGFINYLKNDQKIAFSKVVEIGDFVELD 291
Query: 285 LS 286
S
Sbjct: 292 KS 293
>SPCC126.06 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein
Length = 328
Score = 82.8 bits (203), Expect = 6e-16
Identities = 71/285 (24%), Positives = 130/285 (44%), Gaps = 14/285 (4%)
Query: 14 LNAIAELPTRYASVVAKIEQTDEP---VIKLHDTFHDLDALREFIDGNEDTPYYIIIHDD 70
L + +P R A + E + + V K D +RE + G+E+ P +++++DD
Sbjct: 17 LEEYSSVPVRAAIISISNENSFDVKTMVEKSESIESDFKKVRECLLGSEE-PAFVLVYDD 75
Query: 71 PKSIF---IAYTPDYAPIRSKMLYASSKIAFQRQIGANNL-KSFMFTEPGDIDEKSWTDS 126
K I+Y P+ A +R KMLYASS+ AF R + L +S+ + P ++D + S
Sbjct: 76 SKKNLLQLISYVPENANVRRKMLYASSRAAFVRCVTLAKLDESYFASTPEELDYQQIMKS 135
Query: 127 TAREELMTESELEKLQIDAQQHTMRNSGAVKLVSAHNSTANTLGFKVVDTGNIKPLLEKY 186
+++E + ++L+ +M++S K A ++ K + + +
Sbjct: 136 LSKQEDQSPLRQDELERKEYNESMQSSVTHKRPLVTRGVAMSIDDKALKALSDLKSSTEN 195
Query: 187 NLLVFKIDLGTEEIKIKNKINTSYSAEIIERISSDSPSYCIFHK----SGNYYFILTCPS 242
NL++ ID E I + + +++ SS P++ + S FI CP
Sbjct: 196 NLVILSID--KEVISLSQEKQNIPPSDVKSFFSSTEPNFAFYSLPKDGSSKILFIYICPM 253
Query: 243 GSAIKERMVYAANKRAFLISLKDSDDIEIKRTFEIGDSDELDLSE 287
+ +K RMVY+++K L S+K I I E D+ ++ E
Sbjct: 254 QATVKHRMVYSSSKLGLLDSIKAELGIVIDGKIESNDAADITEKE 298
>Hs6005846 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein
Length = 349
Score = 77.0 bits (188), Expect = 3e-14
Identities = 85/321 (26%), Positives = 148/321 (45%), Gaps = 40/321 (12%)
Query: 1 MSNQSGIIADQEVLNAIAEL---PTRYASVVAKIEQ-----TDEPVIKLHDTFHDLDALR 52
M++Q+GI A +E+ A+ R VV + EQ + EPV + + A+
Sbjct: 1 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDR--AVL 58
Query: 53 EFIDGNEDTPYYIIIHDDPKS------IFIAYTPDYAPIRSKMLYASSKIAFQRQIGANN 106
+D + P Y++ D ++ +F+A++PD +P+R KMLYA+++ +++ G +
Sbjct: 59 PLLDAQQ--PCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGH 116
Query: 107 LKSFMF-TEPGDIDEKSW---TDSTAREELMTESELEKLQIDAQQHTMRNSGAVKLVSAH 162
+K +F T D+ + S A +T +E E QI + S V +
Sbjct: 117 IKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEIS-----VESK 171
Query: 163 NSTANTLGFKVVDTGN--IKPLLEK-YNLLVFKIDLGTEEIKIKNKINTSYSAEIIERIS 219
+ T L F + ++ L +K N + K+DL E I++ + T A++ R+
Sbjct: 172 HQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDV-AQLPSRVP 230
Query: 220 SDSPSYCIF-----HKSG---NYYFILTCPS-GSAIKERMVYAANKRAFLISLKDSDDIE 270
D+ Y F H+ + FI + P +IKERM+Y++ K L S++ +E
Sbjct: 231 RDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLE 290
Query: 271 IKRTFEIGDSDELDLSEFNDE 291
I + EIGD EL DE
Sbjct: 291 IAKKIEIGDGAELTAEFLYDE 311
>Hs4506275 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein
Length = 350
Score = 69.7 bits (169), Expect = 5e-12
Identities = 81/318 (25%), Positives = 145/318 (45%), Gaps = 50/318 (15%)
Query: 1 MSNQSGIIADQEVLNAIAELPT-RYASVVAKIEQTDEPVIKLHDTFHDLDALREFIDG-- 57
MS+Q+GI A ++V A +Y + IE ++ VI + D+ + D
Sbjct: 1 MSHQTGIQASEDVKEIFARARNGKYRLLKISIEN-EQLVIGSYS--QPSDSWDKDYDSFV 57
Query: 58 ----NEDTPYYIIIHDDPKS------IFIAYTPDYAPIRSKMLYASSKIAFQRQIGANNL 107
+ P YI+ D ++ IFIA++PD++ +R KMLYA+++ +++ G ++
Sbjct: 58 LPLLEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI 117
Query: 108 KSFMF-TEPGDI----------DEKSWTDSTAREELMTESELEKLQIDAQQHTMRNS--G 154
K +F T D+ + S TA EE + + ++ ++Q D T + G
Sbjct: 118 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINEVQTDVGVDTKHQTLQG 177
Query: 155 AVKLVSAHNSTANTLGFKVVDTGNIKPLLEKYNLLVFKIDLGTEEIKIKNKINTSYSAEI 214
+S F+ ++ N + L N + +ID+ E I + N NT ++
Sbjct: 178 VAFPISRE-------AFQALEKLNNRQL----NYVQLEIDIKNEIIILANTTNTELK-DL 225
Query: 215 IERISSDSPSYCIF----HKSGNY----YFILTCPSGS-AIKERMVYAANKRAFLISLKD 265
+RI DS Y F G+Y FI + P + +I+ERM+Y++ K L ++
Sbjct: 226 PKRIPKDSARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVER 285
Query: 266 SDDIEIKRTFEIGDSDEL 283
+++ R EI + DEL
Sbjct: 286 QLQMDVIRKIEIDNGDEL 303
>7299845 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein
Length = 343
Score = 67.8 bits (164), Expect = 2e-11
Identities = 76/321 (23%), Positives = 140/321 (42%), Gaps = 41/321 (12%)
Query: 1 MSNQSGIIADQEVLNAIAELPT-RYASVVAKIEQTDEPVIKLHDTFHDLDALREFIDG-- 57
MS+Q+GI A++++ + ++ + IE +T D + + + G
Sbjct: 1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPL 60
Query: 58 -NEDTPYYIIIHDDPKS------IFIAYTPDYAPIRSKMLYASSKIAFQRQIGANNLKSF 110
+D P YI+ D K + I++TPD A IR KM+YAS+K + + G+ +
Sbjct: 61 LEKDVPCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEE 120
Query: 111 MFTEPGD-----------IDEKSWTDSTAREELMTESELEKLQIDAQQHTMRNSGAVKLV 159
+ D D + T+REE + EL K ++ + +T + +
Sbjct: 121 LHATTLDECTLEGYRRHKQDFAAPAPLTSREEEL--KELRKTEVHTEINTNTRHQTLGGI 178
Query: 160 SAHNSTANTLGFKVVDTGNIKPLLEKYNLLVFKIDLGTEEIKIKNKINTSYSAEIIERIS 219
+ S A + + G K++ L F+IDL E+I + A++ +++
Sbjct: 179 NCPLSEATVAAVQDLVRG-------KHDYLQFRIDLEEEQIHVSRAAKVEL-ADLPKQVP 230
Query: 220 SDSPSYCIF-----HKSG---NYYFILTCPSGS-AIKERMVYAANKRAFLISLKDSDDIE 270
D Y +F H+ +Y F+ + P S +++ERM+Y++ K FL L + +E
Sbjct: 231 EDHARYHLFLFRHTHEGDYFESYVFVYSMPGYSCSVRERMMYSSCKAPFLDELA-ALGVE 289
Query: 271 IKRTFEIGDSDELDLSEFNDE 291
+ + EI EL + DE
Sbjct: 290 VVKKLEIDSGSELTEAFLQDE 310
>CE28307 [W] KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein
Length = 333
Score = 62.0 bits (149), Expect = 1e-09
Identities = 68/305 (22%), Positives = 132/305 (42%), Gaps = 30/305 (9%)
Query: 1 MSNQSGIIADQEVLNAI---AELPTRYASVVAKIEQTDEPVIKLHDTFHDLD----ALRE 53
M+ Q+GI A+ + NA+ + R +V E+ P + T + D L +
Sbjct: 1 MACQTGIRANAALRNALNLGKQAKLRLIKIVVNNEEMT-PNYEFAGTANWRDDWRACLPD 59
Query: 54 FIDGNEDTPYYIIIHDDPKSIFIAYTPDYAPIRSKMLYASSKIAFQRQIGANNLKSFMFT 113
+D E ++ + + I + D AP+R KML A++ F+ + G + ++
Sbjct: 60 CVDAYEPCFILFRLNTITEWVLITFVDDRAPVREKMLLAATCATFKSEFG----QCYIEH 115
Query: 114 EPGDIDEKSWTDSTAREELMTESELEKL-QIDAQQHTMRNSGAVKLVSAHNSTANTLGFK 172
E D K T + L ++EL + +++ + H N+ + AH + G
Sbjct: 116 EKHVTDLKDLTLNAFEAWLKAKTELGPMSEVERELH---NAQQERAAIAHAGPQHMKGVA 172
Query: 173 VVDTGNIKPLL-----EKYNLLVFKIDLGTEEIKIKNKINTSYSAEIIERISSDSPSYCI 227
N + L +K + + +D E IK++ + + +++ ++ D P Y
Sbjct: 173 FPVDRNAEEALRQLASQKLSFVQLSVDTLNEAIKLEGTLESLEPSQLASKVPRDKPRYTF 232
Query: 228 FHKSGNY--------YFILTCPS-GSAIKERMVYAANKRAFLISLKDSDDIEIKRTFEIG 278
++ + FI + PS GS+IKERM+Y++ K FL + ++ + I E+
Sbjct: 233 YNFDHTWEGVPQQCTLFIYSLPSSGSSIKERMLYSSCKGPFLSAAQNQYGVVITNKMEVD 292
Query: 279 DSDEL 283
D+L
Sbjct: 293 ARDDL 297
>CE20549 [Z] KOG1735 Actin depolymerizing factor
Length = 152
Score = 49.7 bits (117), Expect = 6e-06
Identities = 24/51 (47%), Positives = 32/51 (62%)
Query: 72 KSIFIAYTPDYAPIRSKMLYASSKIAFQRQIGANNLKSFMFTEPGDIDEKS 122
K IF+ Y PD AP+R +MLYASS A + +G +L +E D+DEKS
Sbjct: 91 KVIFVQYCPDNAPVRRRMLYASSVRALKASLGLESLFQVQASEMSDLDEKS 141
>CE20548 [Z] KOG1735 Actin depolymerizing factor
Length = 293
Score = 49.7 bits (117), Expect = 6e-06
Identities = 24/51 (47%), Positives = 32/51 (62%)
Query: 72 KSIFIAYTPDYAPIRSKMLYASSKIAFQRQIGANNLKSFMFTEPGDIDEKS 122
K IF+ Y PD AP+R +MLYASS A + +G +L +E D+DEKS
Sbjct: 232 KVIFVQYCPDNAPVRRRMLYASSVRALKASLGLESLFQVQASEMSDLDEKS 282
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.132 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,307,918
Number of Sequences: 60738
Number of extensions: 734511
Number of successful extensions: 1695
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1673
Number of HSP's gapped (non-prelim): 12
length of query: 315
length of database: 30,389,216
effective HSP length: 106
effective length of query: 209
effective length of database: 23,950,988
effective search space: 5005756492
effective search space used: 5005756492
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)