ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII3894 check: MH TBLD KOG0890 Cell cycle control, cell division, chromosome partitioning Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination
r_klactIII3894 check: MH TBLD KOG0890 Chromatin structure and dynamics Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination
r_klactIII3894 check: MH TBLD KOG0890 Replication, recombination and repair Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination
r_klactIII3894 check: MH TBLD KOG0890 Signal transduction mechanisms Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII3894 1374743 1367883 -2287
(2287 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 2034 0.0
SPBC216.05 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 502 e-141
Hs4502325 [TBLD] KOG0890 Protein kinase of the PI-3 kinase famil... 381 e-105
Hs22041606 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 368 e-101
At5g40820 [TBLD] KOG0890 Protein kinase of the PI-3 kinase famil... 367 e-101
7293222 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 326 2e-88
ECU02g1130 [TBLD] KOG0890 Protein kinase of the PI-3 kinase fami... 231 1e-59
SPCC23B6.03c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in ... 192 5e-48
Hs20336203 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in te... 191 2e-47
Hs20336199 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in te... 191 2e-47
YBL088c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 181 9e-45
YKL203c [L] KOG0891 DNA-dependent protein kinase 178 8e-44
7299977 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 176 3e-43
CE28813 [L] KOG0891 DNA-dependent protein kinase 176 4e-43
CE07705 [L] KOG0891 DNA-dependent protein kinase 176 4e-43
At3g48190 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in tel... 174 1e-42
YJR066w [L] KOG0891 DNA-dependent protein kinase 171 2e-41
CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 171 2e-41
CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family ... 170 3e-41
SPBC216.07c [L] KOG0891 DNA-dependent protein kinase 166 3e-40
SPBC30D10.10c [L] KOG0891 DNA-dependent protein kinase 161 1e-38
7297995 [L] KOG0891 DNA-dependent protein kinase 155 7e-37
Hs4826730 [L] KOG0891 DNA-dependent protein kinase 149 5e-35
Hs18765739 [L] KOG0891 DNA-dependent protein kinase 147 2e-34
Hs14719394 [L] KOG0891 DNA-dependent protein kinase 147 2e-34
At1g50030 [L] KOG0891 DNA-dependent protein kinase 132 6e-30
CE27869 [L] KOG0891 DNA-dependent protein kinase 130 2e-29
CE22176 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telom... 120 3e-26
7290761 [L] KOG0891 DNA-dependent protein kinase 102 7e-21
Hs13654237 [L] KOG0891 DNA-dependent protein kinase 99 8e-20
CE24760 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 65 1e-09
CE24759 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 65 1e-09
YLR240w [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involve... 64 3e-09
CE05832 [T] KOG0905 Phosphoinositide 3-kinase 64 3e-09
At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 invol... 61 2e-08
Hs4507691 [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TR... 60 3e-08
7302249 [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1... 60 4e-08
CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in i... 55 1e-06
YLR305c [T] KOG0902 Phosphatidylinositol 4-kinase 54 4e-06
CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subu... 53 7e-06
>YBR136w [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2368
Score = 2034 bits (5271), Expect = 0.0
Identities = 1092/2387 (45%), Positives = 1530/2387 (63%), Gaps = 128/2387 (5%)
Query: 6 VKYLEELILALKSAGT-VGNGIELD------STLQLDEKNGKLLQTLLKNTQSTNTDEV- 57
VKYL+ELILA+K + V + +++ S+ Q K+ K+L TL++N + + +
Sbjct: 5 VKYLDELILAIKDLNSGVDSKVQIKKVPTDPSSSQEYAKSLKILNTLIRNLKDQRRNNIM 64
Query: 58 ----IFHKSFQALDLFLRCNQHLFSANVKEITM-IEVILNNMVSCSLMHWSNMQYIWLIN 112
IF K+ AL L L N L I+ ++++ ++ S++++ N IW +
Sbjct: 65 KNDTIFSKTVSALALLLEYNPFLLVMKDSNGNFEIQRLIDDFLNISVLNYDNYHRIWFMR 124
Query: 113 KYVSAWLKA----YSFASTSNLQIWFTEQMVQYEKLLVTCLRGKLEKPTFHSLLKKIVIV 168
+ + +W KA Y + L F M YE+ L L GK E F+ LK + I+
Sbjct: 125 RKLGSWCKACVEFYGKPAKFQLTAHFENTMNLYEQALTEVLLGKTELLKFYDTLKGLYIL 184
Query: 169 NGWIMRDG---------LLRNYSYRRWQSQFQKLMRLLAFVLKSTNEPSVEVASI----L 215
W + L + + ++ FQ+L+R++ +V S ++E A I +
Sbjct: 185 LYWFTSEYSTFGNSIAFLDSSLGFTKFDFNFQRLIRIVLYVFDSCELAALEYAEIQLKYI 244
Query: 216 QLLVRYISLSKESLSI----------FRFSFDLIQTLIKDHHQHIS--PTILAKTLLRTL 263
L+V Y+ S ++ +F + + + + + PT +AK +LR
Sbjct: 245 SLVVDYVCNRTISTALDAPALVCCEQLKFVLTTMHHFLDNKYGLLDNDPT-MAKGILRLY 303
Query: 264 YLCIHDESKLAEIKNTFELHEWINTNKNADPLFIR------SIKYVSVKLGFLESMEEFT 317
LCI ++ + + F + +W + +++ F + SI Y +K L +E
Sbjct: 304 SLCISNDFSKCFVDH-FPIDQWADFSQSEHFPFTQLTNKALSIVYFDLKRRSLP-VEALK 361
Query: 318 FSNKQLHWLHQAIENPKLRLVSGNVRNCIADSADIRSF----YDKVKESLL-----NTIK 368
+ NK W++Q+ + L+ V+ + +R ++K + L N +
Sbjct: 362 YDNKFNIWVYQSEPDSSLKNVTSPFDDRYKQLEKLRLLVLKKFNKTERGTLLKYRVNQLS 421
Query: 369 DGDTAKLTHSMHSI---RQLAIKEKFVNNNLVRSPQ------------------------ 401
G + + I ++I+ F NN+ R
Sbjct: 422 PGFFQRAGNDFKLILNEASVSIQTCFKTNNITRLTSWTVILGRLACLESEKFSGTLPNST 481
Query: 402 -------------VEFNASQNMRLSSLNLVPLHKSLAFQLLAKHVIKSIPITDMPEAMLT 448
+E + +R++ KS F++L + + I + E++L+
Sbjct: 482 KDMDNWYVCHLCDIEKTGNPFVRINPNRPEAAGKSEIFRILHSNFLSHPNIDEFSESLLS 541
Query: 449 GVVLILIEVFSRFEPPKLEETSDLIQQSDGYGCLQVFQXXXXXXXXXXXXXXXXXXPYF- 507
G++ L +FS F+PPKL + + I +S ++ Q P F
Sbjct: 542 GILFSLHRIFSHFQPPKLTDGNGQINKS-----FKLVQKCFMNSNRYLRLLSTRIIPLFN 596
Query: 508 ASLGSKYEDINLKFLIIFLQKPKAPYLTETLHMSWINLIINCNSEYFXXXXXXXXXXFNS 567
S ED + LI FLQ K P + E L ++W L + +++ F FNS
Sbjct: 597 ISDSHNSEDEHTATLIKFLQSQKLPVVKENLVIAWTQLTLTTSNDVFDTLLLKLIDIFNS 656
Query: 568 SDFAEHTMMAAQLRYLSKIQGKSPYQLLSPILPVLFKKMGRSLVEKKLGLQRIVQLVDYP 627
D++ MM Q++ ++KI K+PYQLLSPILPVL +++G++LVE+K+G Q +++L+ Y
Sbjct: 657 DDYSLRIMMTLQIKNMAKILKKTPYQLLSPILPVLLRQLGKNLVERKVGFQNLIELLGYS 716
Query: 628 AKTLLENFQRYVVPSALGQYKSDVITEVARIMSGNDXXXXXXXXXXXXDRNSRQIFAVAL 687
+KT+L+ FQRY++P A+ QYKSDV++E+A+IM D +NSRQIFAVAL
Sbjct: 717 SKTILDIFQRYIIPYAIIQYKSDVLSEIAKIMCDGDTSLINQMKVNLLKKNSRQIFAVAL 776
Query: 688 VKHGFFSIETIQTLFLNTAPKFRKNYITLYLPDYKTLAEVLKMSKQILTLDGQITETERC 747
VKHG FS++ ++TLFLN AP F K YIT YLPDYKTLAE+ K+ K +T D +E
Sbjct: 777 VKHGLFSLDILETLFLNRAPTFDKGYITAYLPDYKTLAEITKLYKNSVTKDASDSENANM 836
Query: 748 VLSSLRFLLITNFSKDKRRGTRFKNIEDWNEEMEEQFQQKLEQNVLGIFQVFSNDMHDSD 807
+L SLRFL ITNF KDKR G+++KNI +W ++ E+ FQ+KL+ N+LGIFQVFS+D+HD +
Sbjct: 837 ILCSLRFL-ITNFEKDKRHGSKYKNINNWTDDQEQAFQKKLQDNILGIFQVFSSDIHDVE 895
Query: 808 GKTSYYEKLRVLNGISFLMKYASKKSIISALAQLSICLQTGSEIPEIQHNTLECWHLLIK 867
G+T+YYEKLRV+NGISFL+ YA KKSIISALAQ+SICLQTG + E+++ CWHLL++
Sbjct: 896 GRTTYYEKLRVINGISFLIIYAPKKSIISALAQISICLQTGLGLKEVRYEAFRCWHLLVR 955
Query: 868 LLNEEQITAIINDLFCLILQKWSTFSSSCKLECQAIFDTLLKDRQKLVLEGRPFILLAFL 927
LN+E+++ +I+ L ILQKWS F+ + +I DTL+K++ L+L+ +P+ LA +
Sbjct: 956 HLNDEELSTVIDSLIAFILQKWSEFNGKLRNIVYSILDTLIKEKSDLILKLKPYTTLALV 1015
Query: 928 NNPEFQVLERHPTVARKVLKVISTTNWLKVFTENLGSNNRYVILQTLLELEKYFSTTIHR 987
PE +L R AR V K+ STT+ + +F NL S+N+YVI Q L ++E Y
Sbjct: 1016 GKPELGILARDGQFARMVNKIRSTTDLIPIFANNLKSSNKYVINQNLDDIEVYLRRKQTE 1075
Query: 988 KHVDVVTKH-DDSSHLSTLLGALLDSTYKFRNRDLKICQIAASCISLIGLLDVTKHALPR 1046
+ +D K +S ++ +LGALLD+++KFRN D +C+ A CIS+IG+LDVTKH R
Sbjct: 1076 RSIDFTPKKVGQTSDITLVLGALLDTSHKFRNLDKDLCEKCAKCISMIGVLDVTKHEFKR 1135
Query: 1047 NTNLSEEICDFNNHSQTVKFLISIVNNILVPAFWQSENPTKQLFVALVMQESLKYCGLSS 1106
T E+ D N+ QT+KFLI ++N+ILVPAFWQSENP+KQLFVALV+QESLKYCGLSS
Sbjct: 1136 TTYSENEVYDLNDSVQTIKFLIWVINDILVPAFWQSENPSKQLFVALVIQESLKYCGLSS 1195
Query: 1107 VNWDINRPDDYPVEAKLWSRFNDISKTTLFPLLSSLYLAQSWKEYVPLSYPSFKVKDGYQ 1166
+WD+N + YP EAKLW +FN +SKTT++PLLSSLYLAQSWKEYVPL YPS K+GY+
Sbjct: 1196 ESWDMNHKELYPNEAKLWEKFNSVSKTTIYPLLSSLYLAQSWKEYVPLKYPSNNFKEGYK 1255
Query: 1167 VWIRNLTLDLLKIGTEEDHPLHVFSSLIREDDGTLSNFLLPFITMDIILRANKHNEYSKI 1226
+W++ TLDLLK GT E+HPLHVFSSLIREDDG+LSNFLLP+I++DII++A K Y+ I
Sbjct: 1256 IWVKRFTLDLLKTGTTENHPLHVFSSLIREDDGSLSNFLLPYISLDIIIKAEKGTPYADI 1315
Query: 1227 IENLSIEFEFIFNFDLQQLNHFQIDSLKMAYNTIFRVYEYCKKWVSSFKQDYQAANGTYM 1286
+ + IEF+ IF +L+ +N+ Q+DSL+M Y +IFRV+EYCKKW + FKQ+Y +GT++
Sbjct: 1316 LNGIIIEFDSIFTCNLEGMNNLQVDSLRMCYESIFRVFEYCKKWATEFKQNYSKLHGTFI 1375
Query: 1287 IQEDKVLQVLDRTERFVNTIPSDTLAKKSLETDSFERSALYLEQSYREHGTSSLASTDLL 1346
I++ K +L R + F+ T PSD LA++SLETDSFERSALYLEQ YR++ + LL
Sbjct: 1376 IKDTKTTNMLLRIDEFLRTTPSDLLAQRSLETDSFERSALYLEQCYRQNPHDKNQNGQLL 1435
Query: 1347 QCIQNTYAEIGDVDAVGGVLKMFSTGNLTTKIEELQYSKNWKMAQDCFEALGDFKLSANS 1406
+ +Q TY EIGD+D++ GVL+ F+TGNL +KIEELQYS+NWK+AQDCF LG F +
Sbjct: 1436 KNLQITYEEIGDIDSLDGVLRTFATGNLVSKIEELQYSENWKLAQDCFNVLGKFSDDPKT 1495
Query: 1407 TTSSELVKSSNMKMLKSMYSHQLYEELLMKVKVHLPETKGFLVDNDGDLLNMGIEAVSQT 1466
TT +MLKSMY HQLY +++ H + K L + + ++G+EA +
Sbjct: 1496 TT----------RMLKSMYDHQLYSQIISNSSFHSSDGKISLSPDVKEWYSIGLEAANLE 1545
Query: 1467 GNIVELTRWIERVEHIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGAQF 1526
GN+ L W+E++E ++ +D +LL YNIAK L A+S ++YI+ F LIG F
Sbjct: 1546 GNVQTLKNWVEQIESLRNIDDREVLLQYNIAKALIAISNEDPLRTQKYIHNSFRLIGTNF 1605
Query: 1527 TIPSTSTTLLKNREVLQKLHALTDIKLLCSAHTQSEFSNASKALDGRLSHVGSDFSPNHY 1586
S TTLLK + +L KLH+L D+ L SA + E+ + + LD R+ +G+DF PNHY
Sbjct: 1606 ITSSKETTLLKKQNLLMKLHSLYDLSFLSSAKDKFEYKSNTTILDYRMERIGADFVPNHY 1665
Query: 1587 LLSIRKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMNALKYNHHSAELEF 1646
+LS+RK+ + + N+ D+ +F L+QL R RLD+A+E LM+ L+ AELEF
Sbjct: 1666 ILSMRKSFDQLKMNEQADADLGKTFFTLAQLARNNARLDIASESLMHCLERRLPQAELEF 1725
Query: 1647 AEILWKQGEKDMALKTVAEITKRFKDDPSTASSENQDFKEVLLKYTEWLDLSNSSVSEQI 1706
AEILWKQGE D ALK V EI ++++++ S + +D VLLK+TEWLDLSN+S SEQI
Sbjct: 1726 AEILWKQGENDRALKIVQEIHEKYQENSSVNA---RDRAAVLLKFTEWLDLSNNSASEQI 1782
Query: 1707 IKQYNELIRFDKNWDAPFYSMGLYYSKLLEKKKAEGYVSDGSLEYRSITNFLTSFEKGSP 1766
IKQY ++ + D WD P+YS+GLYYS+LLE+KKAEGY+++G EYR+I+ FL +FEK +
Sbjct: 1783 IKQYQDIFQIDSKWDKPYYSIGLYYSRLLERKKAEGYITNGRFEYRAISYFLLAFEKNTA 1842
Query: 1767 NIRQSLPKVVTLWLDTAKXXXXXXXXXXXXXXXR----ICNKIDTAVKNCGIHIWYTVLT 1822
+R++LPKV+T WLD A + IC+ ++ A+++C +IWY VLT
Sbjct: 1843 KVRENLPKVITFWLDIAAASISEAPGNRKEMLSKATEDICSHVEEALQHCPTYIWYFVLT 1902
Query: 1823 QLLSRLMHPHTATIHTIVNILFHMTLEYPSVMLWYISILLNSESLERRNIGKQIVEAFQK 1882
QLLSRL+H H ++ I++IL + +EYPS +LWYI+ L+NS S +R GK I+E +++
Sbjct: 1903 QLLSRLLHSHQSSAQIIMHILLSLAVEYPSHILWYITALVNSNSSKRVLRGKHILEKYRQ 1962
Query: 1883 --KNPRTKLPGTAISLVQSLTRVCIKDVKNTASRSGRSIDSDFKFNLELAPNDMCVPVNI 1940
+NP L +A+ L ++LTRVC++DVK+ SRSG+S++ DFKF++ +AP+ M VPV
Sbjct: 1963 HSQNPHD-LVSSALDLTKALTRVCLQDVKSITSRSGKSLEKDFKFDMNVAPSAMVVPVRK 2021
Query: 1941 NLKKLLPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCKK 2000
NL + P + SM +VSI RF S Y VF+SLKKPK+L +IGSDGNIYGIMCKK
Sbjct: 2022 NLDIISPLESNSMRGYQPFRPVVSIIRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCKK 2081
Query: 2001 EDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSL 2060
EDVRQDNQYMQFA TM FLLSKD+ SRKR+LGI Y VLSLREDCG+LE+VPNVVTLRS+
Sbjct: 2082 EDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSI 2141
Query: 2061 LSMKYESMKIKYSLKSLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWFLDNFPDPITWYN 2120
LS KYES+KIKYSLKSL ++WQ D KL F+ + + KFPP+LYQWFL+NFPDPI W+N
Sbjct: 2142 LSTKYESLKIKYSLKSLHDRWQHTAVDGKLEFYMEQVDKFPPILYQWFLENFPDPINWFN 2201
Query: 2121 ARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVP 2180
ARN + RSY+VMAMVGHILGLGDRHCENILLD+ TG+VLHVDFDCLFEKGK+LPVPEIVP
Sbjct: 2202 ARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVP 2261
Query: 2181 FRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKIDESIQNALK 2240
FRLT N+ DA GIIGTEGTFKKSSEVTL +MR NE+ L+N+IETIMYDR +D SIQ ALK
Sbjct: 2262 FRLTPNLLDALGIIGTEGTFKKSSEVTLALMRKNEVALMNVIETIMYDRNMDHSIQKALK 2321
Query: 2241 VLRDKIRGIDARDGLALSVSGQVEALTQESCSVENLSKMYIGWLPFW 2287
VLR+KIRGID +DGL LSV+GQ E L QE+ S +NLSKMYIGWLPFW
Sbjct: 2322 VLRNKIRGIDPQDGLVLSVAGQTETLIQEATSEDNLSKMYIGWLPFW 2368
>SPBC216.05 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2386
Score = 502 bits (1292), Expect = e-141
Identities = 453/1834 (24%), Positives = 817/1834 (43%), Gaps = 163/1834 (8%)
Query: 534 LTETLHMSWINLI-INCNSEYFXXXXXXXXXXFNSSDFAEHTMMAAQLRYLSKIQGKSPY 592
+ ET+ +SWI+L + E NS F + ++A L+ ++ + S +
Sbjct: 636 ILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIGLSA-LQQIASTRHISVW 694
Query: 593 QLLSPILPVLFKKMGRSLVEKKLGLQRIVQLVDYPAKTLLENFQRYVVPSALGQYKSDVI 652
QLLSP P + + + + +K QL++ L Q Y +P + +I
Sbjct: 695 QLLSPYWPTVSVAIVQGMGKKPNIASLFAQLMNISEGDFLIRTQAYTLPFLVLTKNKALI 754
Query: 653 TEVARIMSGNDXXXXXXXXXXXXDRNSRQIFAVALVKHGFFSIETIQTLFLNTAPKFRKN 712
+A + + N +I A L E++ L F K
Sbjct: 755 VRIAELSQSDVATLCLT--------NMHKILASLLTTDHPNLEESVMLLLSLATSDFEKV 806
Query: 713 YITLYLPDYKTLAEVLKMSKQILTLDGQITETERCVLSSLRFLLITNFSKDKRRGTRFKN 772
+T L ++ + ++ ++L L E+ + + +I + + N
Sbjct: 807 DLTSLLR-----SDPISITVELLQLYQNDVPHEKIENALRKVAMIVS---------QVVN 852
Query: 773 IEDW-NEEMEEQFQQKLEQNVLGIFQVFSNDMHDSDGKTSYYEKLRVLNGISFLMKYASK 831
ED N+E+ F ++LGI FSN ++D GKTS EK++ + GI ++
Sbjct: 853 DEDLSNKELLYDF---FNNHILGILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGG 909
Query: 832 KSIISALAQLSICLQTGSEIPEIQHNTLECWHLLIKLLNEEQITAIINDLFCLILQKWST 891
++ L Q+ LQ+ + ++ ++ W LI E + ++I L +IL
Sbjct: 910 -AVKLGLPQILSNLQSAFQNEHLRFYAIKAWFSLILATKEPEYSSIAG-LSLVILPPLFP 967
Query: 892 FSSSCKLECQA-IFDTLLKDRQKLVLEGRPFILLAFLNNPEFQVLERHPTVARKVLKVIS 950
+ + E IFD + D K L+G + + L++ F + A+++ +
Sbjct: 968 YLEPQEAELVIQIFDFISSDTHKC-LQGLKWAIPTSLDSACFSLK------AKEIFCSLQ 1020
Query: 951 TTNW---LKVFTENLGSNNRYVILQTLLELEKYFSTTIHRKHVDVVTKHDDSSHLSTLLG 1007
++ L+ + L + N V L +LE +F + H D + + L LL
Sbjct: 1021 NEDFYSELQSIIKCLTNENEPVCYLGLQKLELFFQAKVDELH-DTLNLDISNEVLDQLLR 1079
Query: 1008 ALLDSTYKFRNRDLKICQIAASCISLIGLLDVTKHALPRNTNLSEEICDFNNHSQTVKFL 1067
LLD K+ + +++I +AA + +G +D ++ + + +F N +++KF+
Sbjct: 1080 CLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKFI 1139
Query: 1068 ISIVNNILVPAFWQSENPTKQLFVALVMQESLKYCGLSSVNWDINRPDDYPVEAKLWSRF 1127
+ + + L+PAF + + Q F+A +QE LK G S IN+ V + W
Sbjct: 1140 LDFMQSQLIPAFLVTTDTKAQGFLAYALQEFLKLGGFKSAV--INKKKGLTVVTEHWMSL 1197
Query: 1128 NDISKTTLFPLLSSLYLAQSWKEYVPLSYPSFKVKDGYQVWIRNLTLDLLKIGTEEDHP- 1186
D+SK L P L+S Y + + + YP +K W++ +L L++ ++
Sbjct: 1198 PDLSKRVLIPFLTSKYHLTPIPK-IDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEK 1256
Query: 1187 -LHVFSSLIREDDGTLSNFLLPFITMDIILRANKHNEYSKIIENLSIEFEFIFNFDLQQ- 1244
+ S ++++ + + FLLPF+ +++IL ++ E +K+IE EF+ + N
Sbjct: 1257 IFGICSKVVKDQEVNIPCFLLPFLVLNVILTESEL-EVNKVIE----EFQLVINQPGPDG 1311
Query: 1245 LNHFQIDSLKMAYNTIFRVYEYCKKWVSSFKQDYQAANGTYMIQEDKVLQVLDRTER--- 1301
LN + F++ +Y KW+ K+ +E++ + V D T R
Sbjct: 1312 LNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESS 1371
Query: 1302 ------FVNTIPSDTLAKKSLETDSFERSALYLEQSYREHGTSSLASTDLLQCIQNTYAE 1355
F++ PS TL SL R+ Y EQ R A + +Q YA
Sbjct: 1372 ISKVESFLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIYAG 1431
Query: 1356 IGDVDAVGGVLKMFSTGNLTTKIEELQYSKNWKMAQDCFEALGDFKLSANSTTSSELVKS 1415
I D D + V F + ++ + S W A C+E + K
Sbjct: 1432 IDDPDEIEAVSLNFHDYSFDQQLLLHENSGTWDSALSCYEII---------IQKDPENKK 1482
Query: 1416 SNMKMLKSMYSHQLYEELLMKVKVHLPETKGFLVDNDGD---LLNMGIEAVSQTGNIVEL 1472
+ + +L SM YE L++ + F+++++ + +LN+GIEA ++ +I L
Sbjct: 1483 AKIGLLNSMLQSGHYESLVLSLD-------SFIINDNHEYSKMLNLGIEASWRSLSIDSL 1535
Query: 1473 TRWIERVEHIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGAQFTIPSTS 1532
+ + + +++ F + Y Q + ++ + + + + A I +T
Sbjct: 1536 KKCLSK-SNLESFEAKLGSIFY------QYLRKDSFAELTERLQPLY--VDAATAIANTG 1586
Query: 1533 T-TLLKNREVLQKLHALTDIKLLCSAHTQSEFS-NASKALDGRLSHVGSDFSPNHYLLSI 1590
+ ++L KLHA+ D + A T S N L RLS V H +LS
Sbjct: 1587 AHSAYDCYDILSKLHAINDFSRI--AETDGIVSDNLDIVLRRRLSQVAPYGKFKHQILST 1644
Query: 1591 RKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMNALKYNHHSAELEFAEIL 1650
+N + +Y +++++ RK + A ++ A+ + A +E A+
Sbjct: 1645 HLVGYEKFENT---KKTAEIYLEIARISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWW 1701
Query: 1651 WKQGEKDMALKT------------VAEITKRFKDDPSTASSENQDFKEVLLKYTEWLDLS 1698
W QG+ A+ V E +R K+ T + + +V LK T+WL +
Sbjct: 1702 WHQGQHRKAISELNFSLNNNMFDLVDEHEERPKNRKETLGNPLKG--KVFLKLTKWLGKA 1759
Query: 1699 NSSVSEQIIKQYNELIRFDKNWDAPFYSMG----LYYS---KLLEKKKAEGYVSDGSLEY 1751
+ + Y++ + + Y +G L Y KL +++E ++S G L
Sbjct: 1760 GQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMYEEEQKLPVNEQSERFLS-GELVT 1818
Query: 1752 RSITNFLTSFEKGSPNIRQSLPKVVTLWLDT-AKXXXXXXXXXXXXXXXRICN--KIDTA 1808
R I F S G+ +I +S+PK++TLWLD A+ I + K
Sbjct: 1819 RIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDGEKYFREHIISSRKKSLE 1878
Query: 1809 VKNCGI---------HIWYTVLTQLLSRLMHPHTATIHTIVNILFHMTLEYPSVMLWYIS 1859
+ N + + + L+Q++SR+ HP+ + +I+ ++ YP LW +
Sbjct: 1879 LMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNNKVYKILEHIIANVVASYPGETLWQLM 1938
Query: 1860 ILLNSESLERRNIGKQIVEAFQKKNPRTK-------LPGTAISLVQSLTRVCIKDVKNTA 1912
+ S S +R GK I+ + L +AI + + L +C + + +
Sbjct: 1939 ATIKSTSQKRSLRGKSILNVLHSRKLSMSSKVDIKALSQSAILITEKLINLCNTRINSKS 1998
Query: 1913 SRSGRSIDSDFKFNLELAPNDMCVPVNINLKKLLPSTATSMNSDL-FKSVMVSIARFSSQ 1971
+ S+ F+ + + P D+ +P L LP+ + S F ++ +F +
Sbjct: 1999 VKM--SLKDHFRLSFD-DPVDLVIPAKSFLDITLPAKDANRASHYPFPKTQPTLLKFEDE 2055
Query: 1972 YMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLLSKDVESRKRN 2030
+ NSL+KP+K+ V G+DGN+Y +CK K+D+R+D + M+F N + +L KD E+ +RN
Sbjct: 2056 VDIMNSLQKPRKVYVRGTDGNLYPFLCKPKDDLRKDARLMEFNNLICKILRKDQEANRRN 2115
Query: 2031 LGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEKWQSI-----P 2085
L I TY V+ L E+CG +E V + R +L Y I S + ++ P
Sbjct: 2116 LCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQKNIPISYQEIKVDLDFALRSPNP 2175
Query: 2086 SDQKLAFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRH 2145
D F K L KFPPV Y+WF+++FP+P W +R + R+ +VM++VG++LGLGDRH
Sbjct: 2176 GD---IFEKKILPKFPPVFYEWFVESFPEPNNWVTSRQNYCRTLAVMSIVGYVLGLGDRH 2232
Query: 2146 CENILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSE 2205
ENIL D TG +HVDF+CLF+KG PE VPFRLT N+ DA G G EG F+K+SE
Sbjct: 2233 GENILFDEFTGEAIHVDFNCLFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGGFRKASE 2292
Query: 2206 VTLRVMRNNEIGLVNIIETIMYDRKID------------ESIQNALKVLRDKIRGIDARD 2253
+T+R++R+N+ L++++E+ ++D ++ L ++R K +G +
Sbjct: 2293 ITMRLLRSNQDTLMSVLESFLHDPLVEWNRKKSSSKYPNNEANEVLDIIRKKFQGFMPGE 2352
Query: 2254 GLALSVSGQVEALTQESCSVENLSKMYIGWLPFW 2287
+ LS+ GQ++ L + + + +NL +MYIGW ++
Sbjct: 2353 TIPLSIEGQIQELIKSAVNPKNLVEMYIGWAAYF 2386
>Hs4502325 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2644
Score = 381 bits (978), Expect = e-105
Identities = 368/1580 (23%), Positives = 704/1580 (44%), Gaps = 140/1580 (8%)
Query: 788 LEQNVLGIFQVFSNDMHDSDGKTSYYEKLRVLNGISFLMKYASKKSIISALAQLSICLQT 847
L+ +LGI F+ + S +K LN + LMK K + S ++ L+T
Sbjct: 1123 LQPKLLGILAFFNMQLLSSS--VGIEDKKMALNSLMSLMKLMGPKHVSSVRVKMMTTLRT 1180
Query: 848 G----SEIPEIQHNTLECWHLLIKLLNEEQITAIINDLFCLILQKWSTFSSSCKLECQAI 903
G + PE+ W ++ L+ + ++++ + +L E AI
Sbjct: 1181 GLRFKDDFPEL---CCRAWDCFVRCLDHACLGSLLSHVIVALLPLIHIQPK----ETAAI 1233
Query: 904 FDTLLKDRQKLVLEGRPFILLAFLNNPEFQVLERHPTVARKVLKVISTTN----WLKVFT 959
F L+ + + V + L P+ L++ V ++ K S + L++
Sbjct: 1234 FHYLIIENRDAVQD----FLHEIYFLPDHPELKKIKAVLQEYRKETSESTDLQTTLQLSM 1289
Query: 960 ENLGSNNRYVILQTLLELEKYFSTTIHRKHVDVVTKHDDSSHLSTLLGALLDSTYK-FRN 1018
+ + N V + L L++ T+++ ++ DS + ++ L+ K ++
Sbjct: 1290 KAIQHENVDVRIHALTSLKE----TLYKNQEKLIKYATDSETVEPIISQLVTVLLKGCQD 1345
Query: 1019 RDLKICQIAASCISLIGLLDVTKHALPRNTNLSEEICDFNNHSQTVKFLISIVNNILVPA 1078
+ + + C+ +G +D + ++ F + F ++ +
Sbjct: 1346 ANSQARLLCGECLGELGAIDPGRLDFSTTETQGKDFT-FVTGVEDSSFAYGLLMELTRAY 1404
Query: 1079 FWQSENPTKQLFVALVMQESLKYCGLSSVNWDINRPDDYPVEAKLWSRFNDISKTTLFPL 1138
++N Q A +QE L +D + +LW RF + + L P
Sbjct: 1405 LAYADNSRAQDSAAYAIQELLSI-------YDCREMETNGPGHQLWRRFPEHVREILEPH 1457
Query: 1139 LSSLYLA-QSWKEYVPLSYPSF--KVKDGYQVWIRNLTLDLL-KIGTEEDHPLHVFSSLI 1194
L++ Y + Q ++ + P + K+ + W + L+ K+ + + S++
Sbjct: 1458 LNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLASKIFTCCSIM 1517
Query: 1195 REDDGTLSNFLLPFITMDIILRANKHNEYSKIIENLSIEFEFIFNFDLQQLNHFQI--DS 1252
+ D ++ +LLP I + ++L N+ ++ E +++ + + D +N I D
Sbjct: 1518 MKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAV----LKHDDQHTINTQDIASDL 1573
Query: 1253 LKMAYNTIFRVYEYCKKWVSSFKQDYQAANGTYMIQE----DKVLQVLDRTE-----RFV 1303
+++ T+F + ++ +W Q +A + D ++ +D + RF+
Sbjct: 1574 CQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDSMVSTVDYEDYQSVTRFL 1633
Query: 1304 NTIPSDTLAKKSLETDSFERSALYLEQSYREHGTSSLASTDLLQCIQNTYAEIGDVDAVG 1363
+ IP DTLA S + ++ R+ ++ E E + + L +Q YA + + D V
Sbjct: 1634 DLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNI---QEHLGFLQKLYAAMHEPDGVA 1690
Query: 1364 GVLKMFSTG-NLTTKIEELQYSKNWKMAQDCFEALGDFKLSANSTTSSELVKSSNMKMLK 1422
GV + +L +I E + + A C++ A +++ + +K
Sbjct: 1691 GVSAIRKAEPSLKEQILEHESLGLLRDATACYDR-------AIQLEPDQIIHYHGV--VK 1741
Query: 1423 SMYSHQLYEELLMKVK-VHLPETKGFLVDNDGDLLNMGIEAVSQTGNIVELTRWIERVEH 1481
SM ++ +V VH ++ +L +EA + L++W + VE+
Sbjct: 1742 SMLGLGQLSTVITQVNGVHANRSEW-----TDELNTYRVEAAWK------LSQW-DLVEN 1789
Query: 1482 IQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGAQFTIPSTSTTLLKNR-- 1539
+ S + ++L + + +++ + + L+ A+ +P ++ + +
Sbjct: 1790 YLAADGKSTTWSVRLGQLLLSAKK---RDITAFYDS-LKLVRAEQIVPLSAASFERGSYQ 1845
Query: 1540 ---EVLQKLHALTDIKLLCSAHTQSEFSNASKALD----GRLSHVGSDFSPNHYLLSIRK 1592
E + +LH L +++ Q ++S+ RL + + +L++R+
Sbjct: 1846 RGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRR 1905
Query: 1593 TVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMNALKYNHHSAELEFAEILWK 1652
+ ++K + + Q +++ RK A L+NA + +E A+ LW
Sbjct: 1906 ALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWS 1965
Query: 1653 QGEKDMALKTVAE-ITKRFKDDPSTASSENQDFK-EVLLKYTEWLDLSNSSVSEQIIKQY 1710
+G+ AL + + + F ++ + +N +L +++ + + S I+K+Y
Sbjct: 1966 KGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKY 2025
Query: 1711 NELIRFDKNWDAPFYSMGLYYSKLLEKKKAEGYVSDGSLEYRSITNFLTSFEKGSPNIRQ 1770
++ W+ + + YY KL+ G L + +F S + G+ I Q
Sbjct: 2026 KDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQ 2085
Query: 1771 SLPKVVTLWLDTA-KXXXXXXXXXXXXXXXRI----CNKIDTAVKN-CGIHIWYTVLTQL 1824
S+P+++TLWLD K R NK+ T N + + T +QL
Sbjct: 2086 SMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITEHTNYLAPYQFLTAFSQL 2145
Query: 1825 LSRLMHPHTATIHTIVNILFHMTLEYPSVMLWYISILLNSESLERRNIGKQIV-EAFQKK 1883
+SR+ H H ++ I+ + L YP +W ++ + S R N K+I+ +A K
Sbjct: 2146 ISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMK 2205
Query: 1884 NPRTKLPGTAISLVQSLTRVCIKDVKNTASRSGRSIDSDFKFNLELAP----NDMCVPVN 1939
K G A L L +C K V ++S S+ + FK +L +++ +P+
Sbjct: 2206 KSLEKFVGDATRLTDKLLELCNKPVDGSSSTL--SMSTHFKMLKKLVEEATFSEILIPLQ 2263
Query: 1940 INLKKLLPST----ATSMNSDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYG 1995
+ LPS A + + F IA F + SL+KPKK+++ GSDG Y
Sbjct: 2264 SVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYI 2323
Query: 1996 IMCK-KEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNV 2054
+MCK K+D+R+D + M+F + ++ L KD ESR+R L I TY V+ L ++CG++E V N
Sbjct: 2324 MMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNT 2383
Query: 2055 VTLRSLLSMKYESMKIKYSLKSLQEKW--QSIPSDQKL-AFHKDCLKKFPPVLYQWFLDN 2111
LR +L+ Y+ + + K L++ +S +KL F + L + PP+ ++WFL
Sbjct: 2384 AGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRT 2443
Query: 2112 FPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGK 2171
FPDP +WY++R+ + RS +VM+MVG+ILGLGDRH ENIL D LTG +HVDF+CLF KG+
Sbjct: 2444 FPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGE 2503
Query: 2172 KLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD--- 2228
VPEIVPFRLT N+ + G +GTEG F+++ EVT+R+MR+ L+++++T ++D
Sbjct: 2504 TFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLV 2563
Query: 2229 ------------------RKIDESIQNALKVLRDKIRGI----DARDGLALSVSGQVEAL 2266
++E + + + +++G+ + GL LS+ G V L
Sbjct: 2564 EWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYL 2623
Query: 2267 TQESCSVENLSKMYIGWLPF 2286
QE+ L +MY+GW P+
Sbjct: 2624 IQEATDENLLCQMYLGWTPY 2643
>Hs22041606 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 1212
Score = 368 bits (944), Expect = e-101
Identities = 312/1237 (25%), Positives = 580/1237 (46%), Gaps = 106/1237 (8%)
Query: 1122 KLWSRFNDISKTTLFPLLSSLYLA-QSWKEYVPLSYPSF--KVKDGYQVWIRNLTLDLL- 1177
+LW RF + + L P L++ Y + Q ++ + P + K+ + W + L+
Sbjct: 9 QLWRRFPEHVREILEPHLNTRYKSSQKSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLIT 68
Query: 1178 KIGTEEDHPLHVFSSLIREDDGTLSNFLLPFITMDIILRANKHNEYSKIIENLSIEFEFI 1237
K+ + + S++ + D ++ +LLP I + ++L N+ ++ E +++ +
Sbjct: 69 KVRHDLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAV----L 124
Query: 1238 FNFDLQQLNHFQI--DSLKMAYNTIFRVYEYCKKWVSSFKQDYQAANGTYMIQE----DK 1291
+ D +N I D +++ T+F + ++ +W Q +A + D
Sbjct: 125 KHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKSNRNKVDS 184
Query: 1292 VLQVLDRTE-----RFVNTIPSDTLAKKSLETDSFERSALYLEQSYREHGTSSLASTDLL 1346
++ +D + RF++ IP DTLA S + ++ R+ ++ E E + + L
Sbjct: 185 MVSTVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNI---QEHL 241
Query: 1347 QCIQNTYAEIGDVDAVGGVLKMFSTG-NLTTKIEELQYSKNWKMAQDCFEALGDFKLSAN 1405
+Q YA + + D V GV + +L +I E + + A C++ A
Sbjct: 242 GFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDR-------AI 294
Query: 1406 STTSSELVKSSNMKMLKSMYSHQLYEELLMKVK-VHLPETKGFLVDNDGDLLNMGIEAVS 1464
+++ + +KSM ++ +V VH ++ +L +EA
Sbjct: 295 QLEPDQIIHYHGV--VKSMLGLGQLSTVITQVNGVHANRSEW-----TDELNTYRVEAAW 347
Query: 1465 QTGNIVELTRWIERVEHIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGA 1524
+ L++W + VE+ + S + ++L + + +++ + + L+ A
Sbjct: 348 K------LSQW-DLVENYLAADGKSTTWSVRLGQLLLSAKK---RDITAFYDS-LKLVRA 396
Query: 1525 QFTIPSTSTTLLKNR-----EVLQKLHALTDIKLLCSAHTQSEFSNASKALD----GRLS 1575
+ +P ++ + + E + +LH L +++ Q ++S+ RL
Sbjct: 397 EQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLFQHSPGDSSQEDSLNWVARLE 456
Query: 1576 HVGSDFSPNHYLLSIRKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMNAL 1635
+ + +L++R+ + ++K + + Q +++ RK A L+NA
Sbjct: 457 MTQNSYRAKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAG 516
Query: 1636 KYNHHSAELEFAEILWKQGEKDMALKTVAE-ITKRFKDDPSTASSENQDFK-EVLLKYTE 1693
+ +E A+ LW +G+ AL + + + F ++ + +N +L
Sbjct: 517 ESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENETPPEGKNMLIHGRAMLLVGR 576
Query: 1694 WLDLSNSSVSEQIIKQYNELIRFDKNWDAPFYSMGLYYSKLLEKKKAEGYVSDGSLEYRS 1753
+++ + + S I+K+Y ++ W+ + + YY KL+ G L
Sbjct: 577 FMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYI 636
Query: 1754 ITNFLTSFEKGSPNIRQSLPKVVTLWLDTA-KXXXXXXXXXXXXXXXRI----CNKIDTA 1808
+ +F S + G+ I QS+P+++TLWLD K R NK+ T
Sbjct: 637 VLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAYEWEKAGRSDRVQMRNDLGKINKVITE 696
Query: 1809 VKN-CGIHIWYTVLTQLLSRLMHPHTATIHTIVNILFHMTLEYPSVMLWYISILLNSESL 1867
N + + T +QL+SR+ H H ++ I+ + L YP +W ++ + S
Sbjct: 697 HTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYP 756
Query: 1868 ERRNIGKQIV-EAFQKKNPRTKLPGTAISLVQSLTRVCIKDVKNTASRSGRSIDSDFKFN 1926
R N K+I+ +A K K G A L L +C K V ++S S+ + FK
Sbjct: 757 MRVNRCKEILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTL--SMSTHFKML 814
Query: 1927 LELAP----NDMCVPVNINLKKLLPST----ATSMNSDLFKSVMVSIARFSSQYMVFNSL 1978
+L +++ +P+ + LPS A + + F IA F + SL
Sbjct: 815 KKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASL 874
Query: 1979 KKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYG 2037
+KPKK+++ GSDG Y +MCK K+D+R+D + M+F + ++ L KD ESR+R L I TY
Sbjct: 875 QKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYA 934
Query: 2038 VLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEKW--QSIPSDQKL-AFHK 2094
V+ L ++CG++E V N LR +L+ Y+ + + K L++ +S +KL F +
Sbjct: 935 VIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFRE 994
Query: 2095 DCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVL 2154
L + PP+ ++WFL FPDP +WY++R+ + RS +VM+MVG+ILGLGDRH ENIL D L
Sbjct: 995 FLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSL 1054
Query: 2155 TGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNN 2214
TG +HVDF+CLF KG+ VPEIVPFRLT N+ + G +GTEG F+++ EVT+R+MR+
Sbjct: 1055 TGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQ 1114
Query: 2215 EIGLVNIIETIMYD---------------------RKIDESIQNALKVLRDKIRGI---- 2249
L+++++T ++D ++E + + + +++G+
Sbjct: 1115 REPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTR 1174
Query: 2250 DARDGLALSVSGQVEALTQESCSVENLSKMYIGWLPF 2286
+ GL LS+ G V L QE+ L +MY+GW P+
Sbjct: 1175 NRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPY 1211
>At5g40820 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2810
Score = 367 bits (943), Expect = e-101
Identities = 378/1609 (23%), Positives = 676/1609 (41%), Gaps = 208/1609 (12%)
Query: 840 QLSICLQTGSEIPEIQHNTLECWHLLIKLLNE---EQITAIINDLFCLILQKWSTFSSSC 896
+L + L E +Q L H + L + I +I+ +F ++ F
Sbjct: 1140 KLMVLLMHAIEKDALQSEGLLVLHFFTRKLADVSPSSIKYVISQIFAALIP----FLEKE 1195
Query: 897 KLECQAIFDTLLKDRQKLVLEGRPFI---LLAFLNNPEFQVLERHPTVARKVLKVISTTN 953
K D ++K ++LVL+ R + + F P L ++ ++S +
Sbjct: 1196 KEGPHVYLDEVVKILEELVLKNRDIVKEHICEFPLLPSIPSLGELNNAIQEARGLMSLKD 1255
Query: 954 WLKVFTENLGSNNRYVILQTLLELEKYFSTTIHRKHVDVVTKH-----DDSSHLSTLLGA 1008
L+ + N V EL K ++ ++ DV D LS+L+
Sbjct: 1256 QLRDIVNGMKHENLNVRYMVACELSKL----LYNRNEDVAALIAGELVSDMEILSSLITY 1311
Query: 1009 LLDSTYKFRNRDL--KICQIAASCISLIGLLDVTKHALPRNTNLSEEICDFNNHSQTVKF 1066
LL + + ++ + A C+ IG +D K + + + D +
Sbjct: 1312 LLQGCAEESRTTVGQRLKLVCADCLGAIGAIDPAKVRVASCSRFKIQCSDDD-------L 1364
Query: 1067 LISIVNNILVPAFWQSENPTKQLFVALVMQESLKYCGLS---SVNWDINRPDDYPVE--- 1120
+ +++ L AF +++ Q AL +QE LK G + N + P ++
Sbjct: 1365 IFELIHKHLARAFRAAQDTIIQDSAALAIQELLKIAGCEPSLAGNVVVLTPQEHVQVNVS 1424
Query: 1121 ---------------AKLWSRFNDISKTTLFPLLSSLYLAQSWKE---YVPLSYPSFKVK 1162
KLW RF++ K + P L+S + + + P+ PS +
Sbjct: 1425 GSRRCGGNNEVKDRGQKLWDRFSNYVKELIAPCLTSRFQLPNVSDPGSAGPIYRPSMSFR 1484
Query: 1163 DGYQVWIRNLTLDLLKIGTEEDHPLHVFSS---LIREDDGTLSNFLLPFITMDIILRANK 1219
WIR LT G+ + +F++ ++R D T + +LLP++ +D++ +
Sbjct: 1485 RWLSYWIRKLTA--FATGSR----VSIFAACRGIVRHDMQT-ATYLLPYLVLDVVCHGTE 1537
Query: 1220 HNEYSKIIENLSIEFEFIFNFDLQQLNHFQIDSLKMAYNTIFRVYEYCKKWVSSFKQDY- 1278
S E LS+ +N F + ++ +F + + +WV KQ
Sbjct: 1538 AARLSISEEILSVLDAAASENSGVTINSFGVGQSEVCVQAVFTLLDNLGQWVDDVKQGVA 1597
Query: 1279 -------------------QAANGTYMIQEDKVLQVLDRTERFVNTIPSDTLAKKSLETD 1319
Q +N T ++D +L + IP TLA+ S
Sbjct: 1598 LSSSLQSSGGRQVAPKSKDQVSNST--TEQDHLLVQCKYVLELLLAIPKVTLARASFRCQ 1655
Query: 1320 SFERSALYLEQSYREHGTSSLASTDLLQCIQNT--------YAEIGDVDAVGGVLKMFST 1371
++ RS +YLE R S + + +N Y+ + + D + G + +
Sbjct: 1656 AYARSLMYLESHVRGKSGSLNPAAEKTGIFENADVSSLMGIYSCLDEPDGLSGFASLSKS 1715
Query: 1372 GNLTTKIEELQYSKNWKMAQDCFEALGDFKLSANSTTSSELVKSSNMKMLKSMYSHQLYE 1431
NL ++ + S NW D F A + + +S S + L +M HQ
Sbjct: 1716 LNLQDQLLINKKSGNWA---DVFTAC---EQALQMEPTSVQRHSDVLNCLLNMCHHQTMV 1769
Query: 1432 ELLMKVKVHLPETKGFLVDNDGDLLNMGIEAVSQTGNIVELTRWIERVEHIQMF---NDP 1488
+ + +PE K G++A + G + +++ + + +D
Sbjct: 1770 THVDGLISRVPEYKK-------TWCTQGVQAAWRLGKWDLMDEYLDGADAEGLLFSSSDS 1822
Query: 1489 SLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGAQFTIPSTSTTLLKNREVLQKLHAL 1548
+ ++AK+L A+ + Q +V I + A + + + KLH L
Sbjct: 1823 NASFDRDVAKILHAMMKKDQYSVAEGIAISKQALIAPLAAAGMDS-YTRAYPFVVKLHLL 1881
Query: 1549 TDIK-----LLCSAHTQSEFSNA----SKALDG---RLSHVGSDFSPNHYLLSIRKTVEI 1596
+++ L ++ + FS + SKA+D RL S LL+ R+ V
Sbjct: 1882 RELEDFQAVLNGDSYLEKSFSTSDQVFSKAVDNWENRLRFTQSSLWTREPLLAFRRLVFG 1941
Query: 1597 ISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMNALKYNHHSAELEFAEILWKQGEK 1656
S L + N + Q ++L R + A ++ A + +E A++LW
Sbjct: 1942 ASG---LGAQVGNCWLQYAKLCRLAGHYETAHRAILEAQASGAPNVHMEKAKLLWITKRS 1998
Query: 1657 DMALKTVAEITKRFKD---DPSTASSEN----------------QDFKE------VLLKY 1691
D A+ + + + D + SS N Q FKE LL Y
Sbjct: 1999 DSAIIELQQSLLNMPEGVVDSTVISSINSLLMAPPNPEPTVRNTQSFKEKKDVAKTLLLY 2058
Query: 1692 TEWLDLSNSSVSEQIIKQYNELIRFDKNWDAPFYSMGLYYSKLLE-----KKKAEGYVSD 1746
++W+ S + ++ Y ++ W+ ++ + YY +L ++++ + S
Sbjct: 2059 SKWIHHSGQKQKKDVLNLYTQVKEL-LPWEKGYFHLAKYYDELYVDARKCQQESSVFSSA 2117
Query: 1747 GSLEYRSITNFLT-----------------SFEKGSPNIRQSLPKVVTLWLDTAKXXXXX 1789
GS + +N T + G N+ Q+LP+++TLW D
Sbjct: 2118 GSKKGSVSSNLSTEKAGWDYLFKGMYFYAKALHSGHKNLFQALPRLLTLWFDFGTIYKTS 2177
Query: 1790 XXXXXXXXXXRICNKIDTAVKNC----GIHIWYTVLTQLLSRLMHPHTATIHTIVNILFH 1845
I + ++ C + W TVL QL+SR+ H + T+ + NI+
Sbjct: 2178 GSAGNKELKSTHMKVIMSLMRGCLKDLPTYQWLTVLPQLVSRICHQNADTVLMVKNIITS 2237
Query: 1846 MTLEYPSVMLWYISILLNSESLERRNIGKQIVEAFQKKNPRTKLPGTAISLVQSLTRVCI 1905
+ ++P LW ++ + S RR +I++ +K ++ SLT I
Sbjct: 2238 VLHQFPQQGLWIMAAVSKSTVPARREAAAEIIQGARKGFNQSDRGHNLFIQFASLTDHFI 2297
Query: 1906 KDVKNTASRSGRSID--SDFKFNLELAPNDMCVPVNINLKKLLPSTATSMNSDLFKSV-- 1961
K + + I+ ++F + P D+ +P+ +L LP+ + N SV
Sbjct: 2298 KLCFHGGQPRSKVINIATEFSALKRMMPLDIIMPIQQSLTISLPAFHMNNNERHSASVFS 2357
Query: 1962 ---MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMS 2017
+ +I+ + + + +SL++PKK+ ++G+DG Y +CK K+D+R+D + M+F ++
Sbjct: 2358 GSDLPTISGIADEAEILSSLQRPKKIILLGNDGIEYPFLCKPKDDLRKDARMMEFTAMIN 2417
Query: 2018 FLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSM------KYESMKIK 2071
LLSK ESR+R L I T+ V L EDCGL+E VP+ LR +L K++ K
Sbjct: 2418 RLLSKYPESRRRKLYIRTFAVAPLTEDCGLVEWVPHTRGLRHILQDIYISCGKFDRQKTN 2477
Query: 2072 YSLKSLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSV 2131
+K + ++ ++ + ++ K L FPPV ++WFL F +P W+ +R + + +V
Sbjct: 2478 PQIKRIYDQC-AVKKEYEMLKTK-ILPMFPPVFHKWFLTTFSEPAAWFRSRVAYAHTTAV 2535
Query: 2132 MAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAF 2191
+MVGHI+GLGDRH ENIL D +G +HVDF CLF+KG +L PE+VPFRLTQN+ D
Sbjct: 2536 WSMVGHIVGLGDRHGENILFDSTSGDCVHVDFSCLFDKGLQLEKPELVPFRLTQNMIDGL 2595
Query: 2192 GIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKID--------------ESIQN 2237
GI G EG F + E+TL V+R + L++I+ET ++D ++ Q
Sbjct: 2596 GITGYEGIFMRVCEITLTVLRTHRETLMSILETFIHDPLVEWTKSHKSSGVEVQNPHAQR 2655
Query: 2238 ALKVLRDKIRGIDARDGLALSVSGQVEALTQESCSVENLSKMYIGWLPF 2286
A+ + +++G+ G+ L V GQ L ++ S+ENL KMYI W+P+
Sbjct: 2656 AISSIEARLQGVVV--GVPLPVEGQARRLIADAVSLENLGKMYIWWMPW 2702
>7293222 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2354
Score = 326 bits (836), Expect = 2e-88
Identities = 376/1637 (22%), Positives = 676/1637 (40%), Gaps = 207/1637 (12%)
Query: 783 QFQQKLEQNVLGIFQVFSNDMHDSDGKTSYYEKLRVLNGISFLMKYASKKSI----ISAL 838
+F + + LG+ F + + + + E+ L + +M++ + + +
Sbjct: 791 EFANFIAERFLGVITYFESCLSEPSFEKPLKEE--TLYSLGQIMRFVGSQHVTQFRFKII 848
Query: 839 AQLSICLQTGSEIPEIQHNTLECWHLLIKLLNEEQITAIINDLFCLILQKWSTFSSSCKL 898
A LS + T E P +Q L+ WH+ + ++N +++ + + LQ + S K
Sbjct: 849 AMLSF-VHTLQE-PRLQRICLKIWHIFLHVVNVQELGPSLGRIVAT-LQPLLADNESVKQ 905
Query: 899 ECQAIFDTLLKDRQKLVLEGRPFILLAFLNN--PEFQVLERHPTVARKVLKVISTTNW-- 954
+L++ L L + N P Q R T + + N
Sbjct: 906 VNDLYEFIILRNASMLGTFITDLYFLDRMENVSPSIQKCIRRHTAHLDLKGLAEEENQSP 965
Query: 955 -----LKVFTENLGSNNRYVILQTLLELEKYFSTTIHRKHVDVVTKHDDSSHLSTLLGAL 1009
L+ +++ V + L L F + + ++++ L ++ L
Sbjct: 966 PLVDQLRFLQKHITDECLQVRVYALQHLGDLFGRRRPKLNSTILSELPLEPMLEQIVNVL 1025
Query: 1010 LDSTYKFRNRDLKICQIAASCISLIGLLDVTKHALPRNTNL-SEEICDFNNHSQ--TVKF 1066
+ ++ D ++ +A C+ +G +D + LP N N S + N S V
Sbjct: 1026 MAGC---QHDDSQLQMASAKCLGELGAIDASY--LPSNYNFASPQHLPLNILSDDFAVLA 1080
Query: 1067 LISIVNNILVPAFWQSENPTKQL-FVALVMQESLKYCGLSSVNWDINRPDDYPVEAK--- 1122
L S+ +Q + TK + +L +QE+L CG+S P E K
Sbjct: 1081 LTSLCRG------YQFQQNTKHVDSFSLAIQETLAICGIS------------PKEQKKVQ 1122
Query: 1123 LWSRFNDISKTTLFPLLSSLYLAQSWKEYVPLSYPSFKVK---DGYQVWI---RNLTLDL 1176
LW + + P+L S Y + L P F + Y+ W + +D
Sbjct: 1123 LWQSLPARMRQLMEPMLHSCYTCVH-RPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDY 1181
Query: 1177 LKIGTEEDHPLHVFSSLIREDDGTLSNFLLPFITMDI------------------ILRAN 1218
L + H L + I+ D LS F P+I + +L+AN
Sbjct: 1182 LP-SSGRRHLLSSYKPCIKRDSNMLSTFY-PYILLHALLECTTEQRNHIQEEFMAVLQAN 1239
Query: 1219 KHN--------EYSKIIENLSIEFEFI-FNFDLQQLNHFQIDSLK--------MAYNTIF 1261
+ + E I EN +FE + ++ L + K +A
Sbjct: 1240 EESSSSVRGRQELGAIKENAFKQFESRKYAAGIKPLASTLVSDRKEDSSRVPRLAGKLCA 1299
Query: 1262 RVYEYCKKWVSSFKQDYQAANGTYMIQEDKVLQVLDRTER----FVNTIPSDTLAKKSLE 1317
+ ++ ++W+ +++ + + G K + +D R F+N IP +++ S
Sbjct: 1300 ELLDFLQRWLREWQRIHGRSTG------GKPPETIDSNYRKIHEFLNLIPKLLVSRASYN 1353
Query: 1318 TDSFERSALYLEQSYREHGTSSLASTDLLQCIQNTYAEIGDVDAVGGVLKMFSTG----- 1372
+ R+ YLE E S + + Y + D D+V G +++ S
Sbjct: 1354 CGEYARALSYLESYLEEGEDKSQRLLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQ 1413
Query: 1373 ------------NLTTKIEELQYSKNWKMAQDCFEALGDFKLSANSTTSSELVKSSNMKM 1420
++ T E+L S + +M D A+ D L T+ +L+ +
Sbjct: 1414 DILVNRLVERQQDMITSYEQLLSSTD-QMQPDHVRAMIDAYLRDTPKTA-QLIADGLWQR 1471
Query: 1421 LKSMYSHQLYEELLMKVKVHLPETKGFLVDNDGDLLNMGIEAVSQTGNIVELTRWIERVE 1480
L YS Q + E ++ L ++ + L A G + R+E
Sbjct: 1472 LSDRYSDQCFAECKSELLWRLGSY------DEMEELQSNWPAQCSQGCLKLRRPLTTRIE 1525
Query: 1481 HIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGAQFTIPSTSTTLLKNRE 1540
+ + + ++ + L++ S QQ + Y N ++ L ++E
Sbjct: 1526 FDSLLDG----MRESVLEELRSCSAVQQHS---YANAYDAVLKLHLV-----HELHCSQE 1573
Query: 1541 VLQKLHALTDIKLLCSAHTQSEFSNASKALDGRLSHVGSDFSPNHYLLSIRKTV------ 1594
+++KL D + + N RL V + S R+ +
Sbjct: 1574 LVEKLEQDRD-----EDNQEKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQR 1628
Query: 1595 EIISKNQ---HLQNDISNVYFQLSQLDRKENRLDLAAEDLMNALKYNHHSAELEFAEILW 1651
+ +N HL+ +++ ++ +Q++R +L A ++ A +Y +E A++LW
Sbjct: 1629 RLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLW 1688
Query: 1652 KQGEKDMALKTVAEITKRFKDDPSTASSENQDFKEVLLKYTEWLDLSNSSVS-----EQI 1706
++G++ MA+ + E + + + L ++L S+ S + +
Sbjct: 1689 QKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAV 1748
Query: 1707 IKQYNELIRFDKNWDAPFYSMGLYYSKLLEKK---KAEGYVSDGSLEYRSITNFLTSFEK 1763
+K + E I + ++ M + K+LE + K+E + + N+ S
Sbjct: 1749 LKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRY 1808
Query: 1764 GSPNIRQSLPKVVTLWLDTAKXXXXXXXXXXXXXX-XRICNKIDTAVKNCGIHIWYTVLT 1822
GS ++ QS+P++++LWLDT + C + TAV +YTV +
Sbjct: 1809 GSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAV-------FYTVYS 1861
Query: 1823 QLLSRLMHPHTATIHTIVNILFHMTLEYPSVMLWYISILLNSESLERRNIGKQIVEAFQK 1882
Q+LSRL HP + N++ + YP LW + S R K ++ +
Sbjct: 1862 QMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRL 1921
Query: 1883 KNPR-TKLPGTAISLVQSLTRVCIKDVKNTASRSGRSIDSDFKFN-LELAP--NDMCVPV 1938
+N KL SL + L + K+V T R+ + D D + + L P + + +P
Sbjct: 1922 QNSTFQKLLQDFNSLTERLMDLTNKEV--TLDRTYKLSDLDTRLSKLCKQPEFSQILLPF 1979
Query: 1939 NINLKKLLPSTATSMNSD------------LFKSVMVSIARFSSQYMVFNSLKKPKKLTV 1986
++ LP + S +S+ F + I+ F ++ S KPKKLT+
Sbjct: 1980 EKYMQPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTI 2039
Query: 1987 IGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDC 2045
SDG Y ++ K K+D+R+D + M+F + L +D +R+R L I TY VL E+C
Sbjct: 2040 RCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEEC 2099
Query: 2046 GLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEKWQSIPSDQKL-----AFHKDCLKKF 2100
GL+E +PN+ + RS+ Y ++ S + LQ ++P + + F K +
Sbjct: 2100 GLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSL--AVPLHESIERKREVFTKQLVPAH 2157
Query: 2101 PPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLH 2160
PPV +W F P +WY ARN ++R+ +VM+MVG+ILGLGDRH ENIL G +H
Sbjct: 2158 PPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVH 2217
Query: 2161 VDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVN 2220
VDF+CLF +G+ LP PE+VPFRLT N+ A G +G EG+F+K E+TLR+++ L++
Sbjct: 2218 VDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMS 2277
Query: 2221 IIETIMYD-----------RKIDESIQNALKVLRDKIRGIDARDGLALSVSGQVEALTQE 2269
I+ +YD KI + +Q L+ ++ A + + LS GQV L E
Sbjct: 2278 ILRPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQA-NSIPLSTEGQVNFLINE 2336
Query: 2270 SCSVENLSKMYIGWLPF 2286
+ V+NL+ MYIGW F
Sbjct: 2337 ATKVDNLASMYIGWGAF 2353
>ECU02g1130 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 1935
Score = 231 bits (588), Expect = 1e-59
Identities = 150/479 (31%), Positives = 246/479 (51%), Gaps = 68/479 (14%)
Query: 1823 QLLSRLMHPHTATIHTIVNILFHMTLEYPSVMLWYISILLNSESLERRNIGKQIVEAFQK 1882
Q+LSRL HP+ + + I+F + YPS W I++NS+ R + IV
Sbjct: 1509 QILSRLSHPNQDVANVVSRIVFELMENYPSKTFWRSLIMMNSQVPSTRKRMEGIVSGLTL 1568
Query: 1883 KNPRTKLPGTAISLVQSLTR--VCIKDVKNTASRSGRSIDSDFKFNLELAPNDMCVPVNI 1940
N A+S V+ ++ CI K ++ +++ DF ++ P + VP
Sbjct: 1569 DNK------VALSNVKRISEELTCISRSK----KNELTMEEDFPAFAKMFPAGVTVP--- 1615
Query: 1941 NLKKLLPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK- 1999
+ V I+ ++ VFNSL++PK++ +GSDG Y +CK
Sbjct: 1616 -------------------NTKVLISGVRNEVKVFNSLQRPKRICFVGSDGKNYYWLCKN 1656
Query: 2000 KEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRS 2059
++D+R+D+++M ++ +L K SRK I TY V+ + G++E + + +L++
Sbjct: 1657 QDDLRKDSRFMDLNLIINSILKKQ-SSRKY---IRTYAVIPFSHESGIIEWIGGLSSLKA 1712
Query: 2060 L---------LSMKYESMKIKYSLKSLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWFLD 2110
+ +S+ + + ++ K +W + S KF P + WF D
Sbjct: 1713 ICDTYYARDGISISETACRFVHNKKIGMREWHRVAS------------KFHPKFHLWFHD 1760
Query: 2111 NFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKG 2170
+FP P +W ARN + ++Y++M +VG +GLGDRH ENIL D TG +HVD +C+F KG
Sbjct: 1761 SFPHPFSWLVARNNYTQTYAIMNIVGWFMGLGDRHAENILFDSNTGDTVHVDLNCIFGKG 1820
Query: 2171 KKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRK 2230
K+L VPE VP+RLTQNI DAFG++G EG++ S TL + N+ LV+ + + +YD
Sbjct: 1821 KELQVPERVPYRLTQNIVDAFGVLGLEGSYNTSLCTTLDLFLKNKNILVSNLLSFVYDPL 1880
Query: 2231 ID---ESIQNALKVLRDKIRGIDARDGLALSVSGQVEALTQESCSVENLSKMYIGWLPF 2286
+ +S K++ D +D D + + + L +E+ + ENL MYIGWLPF
Sbjct: 1881 FEWRRKSATTPKKIIEDLWHKMDDLDACS-----KCDVLNEEATNDENLCMMYIGWLPF 1934
>SPCC23B6.03c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2812
Score = 192 bits (488), Expect = 5e-48
Identities = 200/840 (23%), Positives = 366/840 (42%), Gaps = 142/840 (16%)
Query: 1467 GNIVELTRWI-ERVEHIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGAQ 1525
GN + L +I +++ I +P LL Y +A L+ + R Q C L
Sbjct: 1940 GNYLHLEEYINKKLLLINPNEEPDSLLFYALAYDLKFLIRCNQSQFN-----CDIL---- 1990
Query: 1526 FTIPSTSTTLLKNREVLQKLHALTDIKLLCSAHTQSEFSNASKALDGRLSHVGSDFSPNH 1585
L +N+++ +LH + LL + + K LD LS + F +
Sbjct: 1991 -------QLLKENKQMSSQLHECFQL-LLEIRNVLLSLLQSHKQLD--LSDDLASFR-KY 2039
Query: 1586 YLLSIRKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMNALKYNHHSAELE 1645
Y+L + K IS++ + +++ N + D + DLA E+L H +
Sbjct: 2040 YILELLK----ISESFLIVDNLQNAFSVAMLSDALYRKFDLADENLK-------HDIDFL 2088
Query: 1646 FAEILWKQGEKDMALKTVAEITKRFKDDPSTASSENQDFKEVLLKYT-EWLDLSNSSVSE 1704
++ILW++ EK A+ ++E S + + + F + Y WL + S +E
Sbjct: 2089 SSKILWQRDEKIDAIGMLSE---------SLSKTNSSIFPSISYAYLGNWLYTTKSEKTE 2139
Query: 1705 QIIKQYNE--------------------LIRF-DKNWDAP-----FYSMG-LYYSKLLEK 1737
+ K Y E +F D N+ +P F M LY+ K +
Sbjct: 2140 LVSKNYFEKSLSHMSHLNAKEKAKIYCMFAQFCDNNYSSPDLTEDFKRMEKLYFEKKNDI 2199
Query: 1738 KKAEGYVSDGS-----------------------LEY------------RSITNFLTSFE 1762
++ E + + S EY +SIT++L
Sbjct: 2200 QQLERSIVNASNMKEEKMLKNHHSREMSSFIIDEREYLRMSTFRSKMLTQSITHYLKCLS 2259
Query: 1763 KGSPNIRQSLPKVVTLWLDTAKXXXXXXXXXXXXXXXRICNKIDTAVKNCGIHIWYTVLT 1822
+ N + + T+WL + + N + ++N + V
Sbjct: 2260 ESDEN-DVLISRCCTMWLSNSHLD-------------ELNNSLQHYLQNLPCKKFIPVFY 2305
Query: 1823 QLLSRLMHPHTATIHTIVNILFHMTLEYPSVMLWYI-SILLNSESLERRNIG------KQ 1875
QL +RLM+ ++ ++ +I +++ +P L + S++ N +E + G K+
Sbjct: 2306 QLAARLMNENSKFQQSLTSICYNVGRNHPYHSLHVLFSLVSNVPEIENLDAGSRYRAVKK 2365
Query: 1876 IVEAFQKKNPRTKLPGTAISLVQSLTRVCIKDVKNTASRSGRSIDSDFKFNLELAPNDMC 1935
I++ + + L + ++ + + ++ + S +K+ L+ A N
Sbjct: 2366 ILDLLKVNQGLSNLVTKLLCSFENYVSLAEWNPRSKVDSTSFSRFPGYKWFLKDAANYGL 2425
Query: 1936 VPVNINLKKLLPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYG 1995
P+ +N+K +N S + +++ F + + PK +T +GS+G+ Y
Sbjct: 2426 PPITMNVK---------VNDTGDYSNIPTVSSFDDTIHFASGINAPKVITCLGSNGHTYK 2476
Query: 1996 IMCK--KEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPN 2053
+ K +D+RQD Q ++ L ++ +RNL + TY V+ L G++E V +
Sbjct: 2477 QLVKGGNDDLRQDAVMEQVFEQVNGFLRSYRKTSQRNLSMRTYKVIPLALKTGVIEWVQD 2536
Query: 2054 VVTLRSLLSMKYESMKIK-YSL----KSLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWF 2108
+ L L ++ K +SL K + EK Q + +L + + + PV +F
Sbjct: 2537 TIPLGEYLDSAHKVYHPKEWSLSTCRKLIAEK-QMEDLETRLKVYDLVCRHYRPVFRHFF 2595
Query: 2109 LDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFE 2168
L+++ DP+ W+ + + RS +V +++GH+LGLGDRH +NIL+D +G V+H+D FE
Sbjct: 2596 LESYADPVQWFTTQTNYARSTAVASVLGHVLGLGDRHGQNILIDKTSGEVIHIDLGIAFE 2655
Query: 2169 KGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD 2228
+GKKLPVPE VPFRLT+++ D GI G EG F++ E TL +R E L++++E + YD
Sbjct: 2656 QGKKLPVPECVPFRLTRDVVDGMGITGVEGVFRRCMEFTLETLRREEDSLLSVLEVLRYD 2715
>Hs20336203 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 3056
Score = 191 bits (484), Expect = 2e-47
Identities = 117/375 (31%), Positives = 188/375 (49%), Gaps = 55/375 (14%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
+V+I F +++ + + PK + +GSDG + K ++D+RQD Q + LL
Sbjct: 2680 LVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL 2739
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKY-----SLK 2075
++ E+RKR L I TY V+ L + G+LE V + L + +Y S
Sbjct: 2740 QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAF 2799
Query: 2076 SLQEKWQSIPS---DQKLAFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVM 2132
Q+K + ++K D + F PV + ++ F DP W+ R + RS +
Sbjct: 2800 QCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATS 2859
Query: 2133 AMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFG 2192
++VG+ILGLGDRH +NIL++ + ++H+D FE+GK LP PE VPFRLT++I D G
Sbjct: 2860 SIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG 2919
Query: 2193 IIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD------------------------ 2228
I G EG F++ E T+ VMRN++ L+ I+E ++YD
Sbjct: 2920 ITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETE 2979
Query: 2229 ----------------RKIDESI----QNALKVLRDKIRGIDARDGLALSVSGQVEALTQ 2268
ID+S + L L++K++G++ +G LSV GQV L Q
Sbjct: 2980 LHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVE--EGTVLSVGGQVNLLIQ 3037
Query: 2269 ESCSVENLSKMYIGW 2283
++ +NLS+++ GW
Sbjct: 3038 QAIDPKNLSRLFPGW 3052
>Hs20336199 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 1708
Score = 191 bits (484), Expect = 2e-47
Identities = 117/375 (31%), Positives = 188/375 (49%), Gaps = 55/375 (14%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
+V+I F +++ + + PK + +GSDG + K ++D+RQD Q + LL
Sbjct: 1332 LVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLL 1391
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKY-----SLK 2075
++ E+RKR L I TY V+ L + G+LE V + L + +Y S
Sbjct: 1392 QRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAF 1451
Query: 2076 SLQEKWQSIPS---DQKLAFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVM 2132
Q+K + ++K D + F PV + ++ F DP W+ R + RS +
Sbjct: 1452 QCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATS 1511
Query: 2133 AMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFG 2192
++VG+ILGLGDRH +NIL++ + ++H+D FE+GK LP PE VPFRLT++I D G
Sbjct: 1512 SIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG 1571
Query: 2193 IIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD------------------------ 2228
I G EG F++ E T+ VMRN++ L+ I+E ++YD
Sbjct: 1572 ITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETE 1631
Query: 2229 ----------------RKIDESI----QNALKVLRDKIRGIDARDGLALSVSGQVEALTQ 2268
ID+S + L L++K++G++ +G LSV GQV L Q
Sbjct: 1632 LHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVE--EGTVLSVGGQVNLLIQ 1689
Query: 2269 ESCSVENLSKMYIGW 2283
++ +NLS+++ GW
Sbjct: 1690 QAIDPKNLSRLFPGW 1704
>YBL088c [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2787
Score = 181 bits (460), Expect = 9e-45
Identities = 109/348 (31%), Positives = 182/348 (51%), Gaps = 42/348 (12%)
Query: 1978 LKKPKKLTVIGSDGNIYGIMCK--KEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITT 2035
L PK +T SDG + K +D+RQD Q ++ +L D R +LGI T
Sbjct: 2444 LSLPKIVTFNISDGTTQKALMKGSNDDLRQDAIMEQVFQQVNKVLQNDKVLRNLDLGIRT 2503
Query: 2036 YGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYS-----LKSLQEKWQSIPSDQKL 2090
Y V+ L G++E V N +L +LS + + KI + +K++Q K ++++L
Sbjct: 2504 YKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDKITFDQARKGMKAVQTK----SNEERL 2559
Query: 2091 AFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENIL 2150
+ + P L +F D+FPDP+ W+ A+ + + + ++VG+ILGLGDRH NIL
Sbjct: 2560 KAYLKITNEIKPQLRNFFFDSFPDPLDWFEAKKTYTKGVAASSIVGYILGLGDRHLNNIL 2619
Query: 2151 LDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRV 2210
LD TG +H+D F++GK LP+PE+VPFRLT++I D FG+ G +G F++S E V
Sbjct: 2620 LDCSTGEPIHIDLGIAFDQGKLLPIPELVPFRLTRDIVDGFGVTGVDGLFRRSCERVYAV 2679
Query: 2211 MRNNEIGLVNIIETIMYD----------RKIDE---------SIQNALKVLRDK------ 2245
+R + + ++ ++ + +D +K + + N K + +
Sbjct: 2680 LRKDYVKVMCVLNILKWDPLYSWVMSPVKKYEHLFEEEHEITNFDNVSKFISNNDRNENQ 2739
Query: 2246 -----IRGIDAR-DGLALSVSGQVEALTQESCSVENLSKMYIGWLPFW 2287
++G++ + G LSV V+ L Q++ NLS +Y+GW PF+
Sbjct: 2740 ESYRALKGVEEKLMGNGLSVESSVQDLIQQATDPSNLSVIYMGWSPFY 2787
>YKL203c [L] KOG0891 DNA-dependent protein kinase
Length = 2473
Score = 178 bits (452), Expect = 8e-44
Identities = 126/384 (32%), Positives = 189/384 (48%), Gaps = 58/384 (15%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
+V I++F + V +S ++P+K + GSDG Y + K ED+RQD+ MQ ++ LL
Sbjct: 2090 IVKISKFEPVFSVISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLL 2149
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLK----- 2075
D E +R+L I Y + L GLL VPN T L+ E+ KI +++
Sbjct: 2150 QNDAECFRRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVML 2209
Query: 2076 SLQEKWQSIPSDQKLAFHKDCLKKFPPV-LYQWFLDNFPDPITWYNARNGFVRSYSVMAM 2134
+ + ++ QK+ L LY+ TW R + RS +VM+M
Sbjct: 2210 QMAPDYDNLTLLQKVEVFTYALNNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSM 2269
Query: 2135 VGHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDAFGI 2193
G+ILGLGDRH N++LD +TG+V+H+DF DC + PE VPFRLT+ +T A +
Sbjct: 2270 TGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKFPEKVPFRLTRMLTYAMEV 2329
Query: 2194 IGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD-----------RKIDE--------- 2233
G EG+F+ + E ++V+R+N+ L+ I+E +D +KI+E
Sbjct: 2330 SGIEGSFRITCENVMKVLRDNKGSLMAILEAFAFDPLINWGFDLPTKKIEEETGIQLPVM 2389
Query: 2234 -------------------------SIQNA-----LKVLRDKIRGIDARDGLALSVSGQV 2263
+I+NA LK + DK+ G D R L V QV
Sbjct: 2390 NANELLSNGAITEEEVQRVENEHKNAIRNARAMLVLKRITDKLTGNDIRRFNDLDVPEQV 2449
Query: 2264 EALTQESCSVENLSKMYIGWLPFW 2287
+ L Q++ SVENL + YIGW PFW
Sbjct: 2450 DKLIQQATSVENLCQHYIGWCPFW 2473
>7299977 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 2429
Score = 176 bits (447), Expect = 3e-43
Identities = 225/1033 (21%), Positives = 414/1033 (39%), Gaps = 176/1033 (17%)
Query: 1314 KSLETDSFERSALYLEQSYREHGTSSLAST------DLLQCIQNTYAEIGDVDAVGGVLK 1367
K + + R++L LEQ ++ H +L S + L I+ Y+ + D+ L
Sbjct: 1510 KHQQNQTVVRTSLDLEQEFKRHHFVALRSIGQREEENSLSAIEQAYSCVRDI------LM 1563
Query: 1368 MFSTGNLTTKIEELQYSKNWKMAQDCFEALGDFKLSANSTTS------SEL-VKSSNMKM 1420
S L + + L + + + A+D + +L STT +EL +K N
Sbjct: 1564 EISVECLQSVYKYLTWLCSLQQAEDFCQIQFGTQLDPASTTKIFRKWQTELELKYGNFSC 1623
Query: 1421 LKSMYSHQLYEELLMKVKVHLPETKGFLVDNDGDLLNMGIEAVSQTGNIVELTRWIERVE 1480
+ + +HQ+ L + ++ + D L GIE G + ++ +
Sbjct: 1624 KEYVIAHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGIEECKSAGKLNLAAKYTATLR 1683
Query: 1481 HIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLIGAQFTIPSTSTTLLKNRE 1540
+ P++ I+ +L+ N + +G Q + + N E
Sbjct: 1684 EL-----PNIRESIKISVLLEDAEINLK-------------MGNQQIAKAILDYVTNNNE 1725
Query: 1541 VL---QKLHALT---DIKLLCSAHTQS-----EFSNASKALDGRLSHVGSDFSPNHYLLS 1589
+ Q++ AL + L C+A T S +F+N+ K +D + H
Sbjct: 1726 FVYCVQRVPALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQH------------- 1772
Query: 1590 IRKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMNALKYNHHSAELEFAEI 1649
Q L ++ F QLD ++ AA KY A+ E+ ++
Sbjct: 1773 ----------RQTLSEKYRDI-FDWHQLDAYASKQRTAA--YATIAKY----ADREYQQL 1815
Query: 1650 L-WKQGEKDMALKTVAEITKRFKDDPSTASSENQDFKEVLLKYTEWLDLSNSSVSEQIIK 1708
++ ++ LK + E ++ + ENQD + + ++ + L ++ QI +
Sbjct: 1816 HDYRHSQEYQTLKDIIEQNRQTAE--KVTQRENQDRRVISVQMKRYASLDEQQLN-QIEE 1872
Query: 1709 QYNELIRFDKNWDAPFYSMGLYYSKLLEKKKAEGYVSDGSLEYRSITNFLTSFEKGSPNI 1768
+ E +R ++TN++ S
Sbjct: 1873 KLTEYLRL------------------------------------ALTNYMAYCRLDSGFS 1896
Query: 1769 RQSLPKVVTLWLDTAKXXXXXXXXXXXXXXXRICNK-IDTAVKNCGIHIWYTVLTQLLSR 1827
++ ++++LW A + C + I + + + QL +R
Sbjct: 1897 SAAIYRIISLWFTNA--------------TSKQCQECIKDEILTVPSYKFICAANQLTAR 1942
Query: 1828 LMHPHTATIHTIVNILFHMTLEYPSVMLWYISILL------NSESLERRNIGKQIVEAFQ 1881
L +T+ + + ++L ++P + + L+ + + ER I ++I+
Sbjct: 1943 LNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERSGIARKIIAMIC 2002
Query: 1882 KKNPRTKLPGTAISLVQSLTRVCIKDVKNTASRSGRSIDSDFKFNLELAPNDMCVPVNIN 1941
+KN G ++SL I + R + SD N + + + N+N
Sbjct: 2003 EKNGTA---GECSKQLESLLPALITFANEGKTNDNRPV-SDSVRNKQF--DKVRRWRNLN 2056
Query: 1942 LKKLLPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-K 2000
M S + ++S+ +++++ L P K+ + SDG I + K K
Sbjct: 2057 AVHCPTLELPVMPSKEYS--IISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGK 2114
Query: 2001 EDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSL 2060
+D+RQD Q ++ LL++D E +R L + TY V L G+LE N V +
Sbjct: 2115 DDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHY 2174
Query: 2061 LSMKYES-MKIKY--------SLKSLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWFLDN 2111
L ++ + +Y + L P + + A +K + PV + + L+
Sbjct: 2175 LVVEGKGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKKICENIKPVFHYFLLEK 2234
Query: 2112 FPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGK 2171
FP P W+ R + S + +MVG++LGLGDRH +NIL+D T V+H+DF FE+GK
Sbjct: 2235 FPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGK 2294
Query: 2172 KLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD--- 2228
PE VPFRLT++ GI GT+G F KS E T+ ++R + I+E ++YD
Sbjct: 2295 IQTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLF 2354
Query: 2229 ------------RKIDESI----QNALKVLRDKIRGIDARDGLALSVSGQVEALTQESCS 2272
+ +ES+ Q AL ++++K+ G +A +V QVE L E+
Sbjct: 2355 IWGVLKKKQSPQQSGEESVNLVAQRALLLVQNKLDGREAGTMGDSNVEAQVERLINEATL 2414
Query: 2273 VENLSKMYIGWLP 2285
NL ++ GW P
Sbjct: 2415 PSNLCMLFPGWDP 2427
>CE28813 [L] KOG0891 DNA-dependent protein kinase
Length = 687
Score = 176 bits (446), Expect = 4e-43
Identities = 120/374 (32%), Positives = 198/374 (52%), Gaps = 50/374 (13%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
+VSI FSS+ V S ++P+K+ + GS+G Y + K ED RQD + MQ ++ LL
Sbjct: 316 IVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLL 375
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSL----KS 2076
+ + E+ +RNL I Y +++L +D GL+ VPN TL +L+ +Y K K L K+
Sbjct: 376 ANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVK-EYREKKAKIPLSIEHKT 434
Query: 2077 LQE---KWQSIPSDQKLAFHKDCLK--KFPPVLYQWFLDNFPDPITWYNARNGFVRSYSV 2131
LQ+ + + + QKL + L + + + +L + P W++ R + RS +
Sbjct: 435 LQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKS-PSSEVWFDRRTNYTRSVAC 493
Query: 2132 MAMVGHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDA 2190
M+MVG+ILGLGDRH N++LD LTG+V+H+DF DC + PE VPFRLT+ + +A
Sbjct: 494 MSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINA 553
Query: 2191 FGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKID------------------ 2232
+ G +G + ++E L+++R N+ L+ ++E +YD I+
Sbjct: 554 MEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKTRKDTG 613
Query: 2233 -------------ESIQNALKVLRDKIRGID--ARDGLA----LSVSGQVEALTQESCSV 2273
+ + ++ ++ K+ G + DG L V+ Q+ LT+++ S
Sbjct: 614 GRQNMAGAVLPSSSTTDSIMETIKRKLDGTEFVHTDGSTPPEPLQVTEQLAMLTEQATSP 673
Query: 2274 ENLSKMYIGWLPFW 2287
NL + YIGW PFW
Sbjct: 674 LNLCQSYIGWCPFW 687
>CE07705 [L] KOG0891 DNA-dependent protein kinase
Length = 2697
Score = 176 bits (446), Expect = 4e-43
Identities = 120/374 (32%), Positives = 198/374 (52%), Gaps = 50/374 (13%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
+VSI FSS+ V S ++P+K+ + GS+G Y + K ED RQD + MQ ++ LL
Sbjct: 2326 IVSIQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLL 2385
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSL----KS 2076
+ + E+ +RNL I Y +++L +D GL+ VPN TL +L+ +Y K K L K+
Sbjct: 2386 ANNSETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVK-EYREKKAKIPLSIEHKT 2444
Query: 2077 LQE---KWQSIPSDQKLAFHKDCLK--KFPPVLYQWFLDNFPDPITWYNARNGFVRSYSV 2131
LQ+ + + + QKL + L + + + +L + P W++ R + RS +
Sbjct: 2445 LQKLSLETEHLTLMQKLQLFESALSVTQGEDLRHVLWLKS-PSSEVWFDRRTNYTRSVAC 2503
Query: 2132 MAMVGHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDA 2190
M+MVG+ILGLGDRH N++LD LTG+V+H+DF DC + PE VPFRLT+ + +A
Sbjct: 2504 MSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLINA 2563
Query: 2191 FGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKID------------------ 2232
+ G +G + ++E L+++R N+ L+ ++E +YD I+
Sbjct: 2564 MEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKTRKDTG 2623
Query: 2233 -------------ESIQNALKVLRDKIRGID--ARDGLA----LSVSGQVEALTQESCSV 2273
+ + ++ ++ K+ G + DG L V+ Q+ LT+++ S
Sbjct: 2624 GRQNMAGAVLPSSSTTDSIMETIKRKLDGTEFVHTDGSTPPEPLQVTEQLAMLTEQATSP 2683
Query: 2274 ENLSKMYIGWLPFW 2287
NL + YIGW PFW
Sbjct: 2684 LNLCQSYIGWCPFW 2697
>At3g48190 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 3856
Score = 174 bits (442), Expect = 1e-42
Identities = 115/354 (32%), Positives = 171/354 (47%), Gaps = 40/354 (11%)
Query: 1969 SSQYMVFNSLKKPKKLTVIGSDGNIYGIMCKK--EDVRQDNQYMQFANTMSFLLSKDVES 2026
S V N + PK + GSDG Y + K +D+RQD QF ++ L + ++
Sbjct: 3500 SDSVTVMNGINAPKVVECFGSDGQKYKQLAKSGNDDLRQDAVMEQFFGLVNTFLHNNRDT 3559
Query: 2027 RKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLL--SMKYESMKIKYSLKSLQ----EK 2080
KR L + TY V+ G+LE V + L L S + E +Y + + + +
Sbjct: 3560 WKRRLAVRTYKVIPFTPSAGVLEWVDGTIPLGDYLIGSSRSEGAHGRYGIGNWKYPKCRE 3619
Query: 2081 WQSIPSDQKLAFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILG 2140
S D++ AF C F PV++ +FL+ F P W+ R + RS + +MVG+I+G
Sbjct: 3620 HMSSAKDKRKAFVDVCTN-FRPVMHYFFLEKFLQPADWFVKRLAYTRSVAASSMVGYIVG 3678
Query: 2141 LGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTF 2200
LGDRH NIL+D T V+H+D FE+G L PE VPFRLT++I D GI G EG F
Sbjct: 3679 LGDRHAMNILIDQATAEVVHIDLGVAFEQGLMLKTPERVPFRLTRDIIDGMGITGVEGVF 3738
Query: 2201 KKSSEVTLRVMRNNEIGLVNIIETIM-----------------------YDRKIDESIQN 2237
++ E TL VMR N+ L+ I+E + YD E +Q
Sbjct: 3739 RRCCEETLSVMRTNKEALLTIVEVFIHDPLYKWALSPLKALQRQKETEDYDGMNLEGLQE 3798
Query: 2238 ALKVLRDKIRGI-------DARDGLAL-SVSGQVEALTQESCSVENLSKMYIGW 2283
+ +D R + D +G + S+ GQ + L Q++ + LS M+ GW
Sbjct: 3799 EFEGNKDATRALMRVKQKLDGYEGGEMRSIHGQAQQLIQDAIDTDRLSHMFPGW 3852
>YJR066w [L] KOG0891 DNA-dependent protein kinase
Length = 2470
Score = 171 bits (432), Expect = 2e-41
Identities = 124/383 (32%), Positives = 186/383 (48%), Gaps = 58/383 (15%)
Query: 1963 VSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLLS 2021
+ IA+F + V +S ++P+K ++ GSDG Y + K ED+RQD+ MQ ++ LL
Sbjct: 2088 IRIAKFEPLFSVISSKQRPRKFSIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLK 2147
Query: 2022 KDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLK-----S 2076
D E KR+L I Y + L GLL VPN T L+ ++ KI +++
Sbjct: 2148 NDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVLIREHRDAKKIPLNIEHWVMLQ 2207
Query: 2077 LQEKWQSIPSDQKLAFHKDCLKKFPPV-LYQWFLDNFPDPITWYNARNGFVRSYSVMAMV 2135
+ ++++ QK+ L LY+ TW R + RS +VM+M
Sbjct: 2208 MAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSSETWLERRTTYTRSLAVMSMT 2267
Query: 2136 GHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDAFGII 2194
G+ILGLGDRH N++LD +TG+V+H+DF DC + PE VPFRLT+ +T A +
Sbjct: 2268 GYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVS 2327
Query: 2195 GTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD-----------RKIDESI-------- 2235
G EG+F+ + E +RV+R+N+ L+ I+E D +K+ E
Sbjct: 2328 GIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWGFDLPPQKLTEQTGIPLPLIN 2387
Query: 2236 ----------------------QN------ALKVLR---DKIRGIDARDGLALSVSGQVE 2264
QN A+ VLR DK+ G D + L V QV+
Sbjct: 2388 PSELLRKGAITVEEAANMEAEQQNETKNARAMLVLRRITDKLTGNDIKRFNELDVPEQVD 2447
Query: 2265 ALTQESCSVENLSKMYIGWLPFW 2287
L Q++ S+E L + YIGW PFW
Sbjct: 2448 KLIQQATSIERLCQHYIGWCPFW 2470
>CE28250 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2514
Score = 171 bits (432), Expect = 2e-41
Identities = 262/1215 (21%), Positives = 486/1215 (39%), Gaps = 162/1215 (13%)
Query: 1170 RNLTLDLLKIGT-EEDHPLHVFSSLIREDDGT-LSNFLLPFITMDIILRANKHNEYSKII 1227
R LT+ +LK ED PL +S+ DD LS + FI I H E +
Sbjct: 1359 RWLTVIILKCAEMSEDAPLSSLASIAHVDDTRFLSKLAMRFILTVI------HMERDSVT 1412
Query: 1228 ENLSIEFEFIFNFDLQQLNHFQI-DSLKMAYNTIFRVYEYCKKWVSSFKQDYQAANGTYM 1286
+ + FE L NH ++ +S + + +F V+++ + SS + + +
Sbjct: 1413 QWILSTFEEA----LTNTNHRRLTNSDRGPASFVFYVFDFIYSYSSSEELRKKKKIWEKV 1468
Query: 1287 IQEDKVLQVLDRTERFVNTIPSDTLAKKSLETDSFE-RSALYLE---QSYREHGTSSLAS 1342
I K + + + P L K ET E R L+LE + R+ T +
Sbjct: 1469 ISFWKSMMSWTFKDENGHGQP---LIVKVAETFGMEKRCILWLEMFMEQKRKTSTEIESE 1525
Query: 1343 TDLLQ--CIQNTYAEIGDVDAVGGVLKMFSTGNLTTKIEELQYSKNWKMAQDCFEALGDF 1400
T+ + N Y I +++ V G S + ++ EA GDF
Sbjct: 1526 TEAAYYFTLMNLYGRIHELNGVRGAYARLSRIQIDHVYGKISMR----------EAFGDF 1575
Query: 1401 KLSANSTTSSELVKSSNMKMLKSMYSHQLYEEL--LMKVKVHLPETKGFLVDNDGDLLNM 1458
NS + + +L +EL L ++ E + +L N L+
Sbjct: 1576 ----NSAACFARMTGKGKPFNSTEAIQKLIDELNCLEYSQIERNEQEDYL--NSLKTLSQ 1629
Query: 1459 GIEAVSQTGNIVELTRWIERVEHIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKC 1518
IE + I+++ R ER E + A+ + + +ER +++C
Sbjct: 1630 NIEYWATESTILKMIRNDERDEIVN-----------------NAIENAKSKVIER-LSEC 1671
Query: 1519 FTLIGAQFTIPSTSTTLLKNREVLQKLHALTDIKLLC----SAHTQSEFSNASKALDG-- 1572
IG + + L++ LQKL+ + ++K + SA + N K D
Sbjct: 1672 --AIGGSCSYEIATPFLVE----LQKLNEIVELKNVSNDELSAFNSDFWKNIQKRTDDSE 1725
Query: 1573 -RLSHVGSDFSPNHYLLSIRKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDL 1631
++S + +L IR +++++ I V+ Q +++ R + A L
Sbjct: 1726 QKISILEPILRVRRSMLDIRMQSMTGRDKENIRSRIVEVHLQSARIARLTGCFERAQLSL 1785
Query: 1632 MNALKYN--HHSAELEFAEILWKQGEKDMALKTVAEI-TKRFKD----DPSTASSENQDF 1684
+NA K + LE A++ + ++ + + I +K F D T S N D
Sbjct: 1786 INAKKVLPFENKIVLEEAKLQLQTSDELNGMSLLDSIISKNFGDLHTIYTDTQQSVNLDV 1845
Query: 1685 -KEVLLKYTEWLDLSNSSVSEQIIKQYNELIR------FDKNWDAP------FYSMGLYY 1731
K LK + + + + S + + + +I+ FDK + F G+ Y
Sbjct: 1846 QKSAKLKIEHYQEETKNLFSSVQMLRISHMIKAGNTIGFDKVYHETTQLLQCFAHSGVMY 1905
Query: 1732 SK------LLEKKKAEGYVSDGSLEYRSITNFLTSFEKGSPNIRQSLPKVVTLWLDTAKX 1785
L K+ +V Y+ + + EK +++ ++ +LWL +
Sbjct: 1906 EAAWLLDYLSNYKERSKHVLPLLKAYKEVAKY----EKNQVLQARAVERMTSLWLSNTRK 1961
Query: 1786 XXXXXXXXXXXXXXRICN----------KIDTAVKNCGIHIWYTVLTQLLSRLMHPHTAT 1835
+I + +I TA+++ G +Y L + H
Sbjct: 1962 ISTHISSVPKLPEGQISDLRQNIKSMNREIQTALEHIGWRAFYPAYAVLARHIDHQDEEV 2021
Query: 1836 IHTIVNILFHMTLEYPSVMLWYISILLNSESLERRNIGKQIVEAFQKKNPRTKLPGTAIS 1895
TI I+ + L P +W + LL + +++ ++K P
Sbjct: 2022 TRTIKQIMKQLILRMPHQCMWQSAYLLRQNIASVKEKYMEVLTEVKRKAPCYVTLIDQYD 2081
Query: 1896 LVQSLTRVCIKDVKNTASRSGRSIDS------DFKFNLELAPNDMCVPVNINLK-KLLPS 1948
+ V++ + +D D K++ P ++ + ++ K+L
Sbjct: 2082 YASGVFNTVSGKVESDDCKLSEKVDGLKTMFRDKKYD----PKELVMNRRVDCDCKILSG 2137
Query: 1949 TATSMNSDLFKSVMVSIAR------------------FSSQYMVFNSLKKPKKLTVIGSD 1990
+ S + +SV + R FS + V +S KP + +
Sbjct: 2138 IMVPVRSVIDESVHDTEIRDDGFEESCHLPDRYLIHDFSDKVKVLHSNTKPVIIKLTTKT 2197
Query: 1991 GNIYGIMCKKED-VRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLE 2049
G I ++CKK+D + +D + + + LL KD ++R + + TTY V+ L + G++E
Sbjct: 2198 GRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQGGIIE 2257
Query: 2050 IVPNVVTLRSLLS--MKYESMKIKYSLKSLQEKWQSIPSDQKLAFHKD-CLKKFPPVLYQ 2106
+ V + L M S + LK + + +++ + ++ K P V+ +
Sbjct: 2258 FMEGVTSFYETLDKLMGMTSGEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTPVVMGK 2317
Query: 2107 WFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCL 2166
WF +P+ W+ +R F +S +VM+++G+I GLGDRH +N+++ TG+ +HVDFD +
Sbjct: 2318 WFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVHT-TGKCIHVDFDMI 2376
Query: 2167 FEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNE-------IGLV 2219
F KG+ L PE+VPFRLTQN+ + G + +G F+ E LRV R N L
Sbjct: 2377 FNKGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFRENSYEIEKYIADLP 2436
Query: 2220 NIIETIMYDRKI--DESIQNALKVLRDKIRGIDARDGL--------ALSVSGQVEALTQE 2269
N++ +++ D + A +++ ++RG L + VS +L +
Sbjct: 2437 NLVADFPSNKRAPKDFDMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLASSLIEL 2496
Query: 2270 SCSVENLSKMYIGWL 2284
+ S E LS+MY+GW+
Sbjct: 2497 ATSEEKLSEMYLGWM 2511
>CE25103 [TBLD] KOG0890 Protein kinase of the PI-3 kinase family involved in
mitotic growth DNA repair and meiotic recombination
Length = 2531
Score = 170 bits (430), Expect = 3e-41
Identities = 262/1220 (21%), Positives = 491/1220 (39%), Gaps = 155/1220 (12%)
Query: 1170 RNLTLDLLKIGT-EEDHPLHVFSSLIREDDGT-LSNFLLPFITMDIILRANKHNEYSKII 1227
R LT+ +LK ED PL +S+ DD LS + FI I H E +
Sbjct: 1359 RWLTVIILKCAEMSEDAPLSSLASIAHVDDTRFLSKLAMRFILTVI------HMERDSVT 1412
Query: 1228 ENLSIEFEFIFNFDLQQLNHFQI-DSLKMAYNTIFRVYEYCKKWVSSFKQDYQAANGTYM 1286
+ + FE L NH ++ +S + + +F V+++ + SS + + +
Sbjct: 1413 QWILSTFEEA----LTNTNHRRLTNSDRGPASFVFYVFDFIYSYSSSEELRKKKKIWEKV 1468
Query: 1287 IQEDKVLQVLDRTERFVNTIPSDTLAKKSLETDSFE-RSALYLE---QSYREHGTSSLAS 1342
I K + + + P L K ET E R L+LE + R+ T +
Sbjct: 1469 ISFWKSMMSWTFKDENGHGQP---LIVKVAETFGMEKRCILWLEMFMEQKRKTSTEIESE 1525
Query: 1343 TDLLQ--CIQNTYAEIGDVDAVGGV---LKMFSTGNLTTKIEELQYSKNWKMAQDCFEAL 1397
T+ + N Y I +++ V G L ++ KI + ++ A CF +
Sbjct: 1526 TEAAYYFTLMNLYGRIHELNGVRGAYARLSRIQIDHVYGKISMREAFGDFNSAA-CFARM 1584
Query: 1398 GDFKLSANSTTSSELVKSSNMKMLKSMYSHQLYEELLMKVKVHLPETKGFLVDND----G 1453
NST + + + + S E+ L +K ++ +DND
Sbjct: 1585 TGKGKPFNSTEAIQKLIDELNCLEYSQIERNEQEDYLNSLKTL---SQWVNIDNDIGPSP 1641
Query: 1454 DLLNMGIEAVSQTGNIVELTRWIERVEHIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVER 1513
+ + IE + I+++ R ER E + A+ + + +ER
Sbjct: 1642 HIFSRNIEYWATESTILKMIRNDERDEIVN-----------------NAIENAKSKVIER 1684
Query: 1514 YINKCFTLIGAQFTIPSTSTTLLKNREVLQKLHALTDIKLLC----SAHTQSEFSNASKA 1569
+++C IG + + L++ LQKL+ + ++K + SA + N K
Sbjct: 1685 -LSEC--AIGGSCSYEIATPFLVE----LQKLNEIVELKNVSNDELSAFNSDFWKNIQKR 1737
Query: 1570 LDG---RLSHVGSDFSPNHYLLSIRKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDL 1626
D ++S + +L IR +++++ I V+ Q +++ R +
Sbjct: 1738 TDDSEQKISILEPILRVRRSMLDIRMQSMTGRDKENIRSRIVEVHLQSARIARLTGCFER 1797
Query: 1627 AAEDLMNALKYN--HHSAELEFAEILWKQGEKDMALKTVAEI-TKRFKD----DPSTASS 1679
A L+NA K + LE A++ + ++ + + I +K F D T S
Sbjct: 1798 AQLSLINAKKVLPFENKIVLEEAKLQLQTSDELNGMSLLDSIISKNFGDLHTIYTDTQQS 1857
Query: 1680 ENQDF-KEVLLKYTEWLDLSNSSVSEQIIKQYNELIR------FDKNWDAP------FYS 1726
N D K LK + + + + S + + + +I+ FDK + F
Sbjct: 1858 VNLDVQKSAKLKIEHYQEETKNLFSSVQMLRISHMIKAGNTIGFDKVYHETTQLLQCFAH 1917
Query: 1727 MGLYYSK------LLEKKKAEGYVSDGSLEYRSITNFLTSFEKGSPNIRQSLPKVVTLWL 1780
G+ Y L K+ +V Y+ + + EK +++ ++ +LWL
Sbjct: 1918 SGVMYEAAWLLDYLSNYKERSKHVLPLLKAYKEVAKY----EKNQVLQARAVERMTSLWL 1973
Query: 1781 DTAKXXXXXXXXXXXXXXXRICN----------KIDTAVKNCGIHIWYTVLTQLLSRLMH 1830
+ +I + +I TA+++ G +Y L + H
Sbjct: 1974 SNTRKISTHISSVPKLPEGQISDLRQNIKSMNREIQTALEHIGWRAFYPAYAVLARHIDH 2033
Query: 1831 PHTATIHTIVNILFHMTLEYPSVMLWYISILLNSESLERRNIGKQIVEAFQKKNPRTKLP 1890
TI I+ + L P +W + LL + +++ ++K P
Sbjct: 2034 QDEEVTRTIKQIMKQLILRMPHQCMWQSAYLLRQNIASVKEKYMEVLTEVKRKAPCYVTL 2093
Query: 1891 GTAISLVQSLTRVCIKDVKNTASRSGRSIDS------DFKFNLELAPNDMCVPVNINLK- 1943
+ V++ + +D D K++ P ++ + ++
Sbjct: 2094 IDQYDYASGVFNTVSGKVESDDCKLSEKVDGLKTMFRDKKYD----PKELVMNRRVDCDC 2149
Query: 1944 KLLPSTATSMNSDLFKSVMVSIAR------------------FSSQYMVFNSLKKPKKLT 1985
K+L + S + +SV + R FS + V +S KP +
Sbjct: 2150 KILSGIMVPVRSVIDESVHDTEIRDDGFEESCHLPDRYLIHDFSDKVKVLHSNTKPVIIK 2209
Query: 1986 VIGSDGNIYGIMCKKED-VRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLRED 2044
+ G I ++CKK+D + +D + + + LL KD ++R + + TTY V+ L +
Sbjct: 2210 LTTKTGRIVRLICKKDDDLSKDYHFTKMVEMCNDLLMKDEQTRIQKMTATTYSVIPLGKQ 2269
Query: 2045 CGLLEIVPNVVTLRSLLS--MKYESMKIKYSLKSLQEKWQSIPSDQKLAFHKD-CLKKFP 2101
G++E + V + L M S + LK + + +++ + ++ K P
Sbjct: 2270 GGIIEFMEGVTSFYETLDKLMGMTSGEWLEKLKFWNTHMKPMGKEERTKYFREVACKNTP 2329
Query: 2102 PVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHV 2161
V+ +WF +P+ W+ +R F +S +VM+++G+I GLGDRH +N+++ TG+ +HV
Sbjct: 2330 VVMGKWFRIQYPEAGQWFASRKLFAKSTAVMSVIGYIFGLGDRHTKNLMVHT-TGKCIHV 2388
Query: 2162 DFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNE------ 2215
DFD +F KG+ L PE+VPFRLTQN+ + G + +G F+ E LRV R N
Sbjct: 2389 DFDMIFNKGETLGTPELVPFRLTQNMINGMGEVALDGEFRTVCEQALRVFRENSYEIEKY 2448
Query: 2216 -IGLVNIIETIMYDRKI--DESIQNALKVLRDKIRGIDARDGL--------ALSVSGQVE 2264
L N++ +++ D + A +++ ++RG L + VS
Sbjct: 2449 IADLPNLVADFPSNKRAPKDFDMSEAKRLVSGRLRGQIMTAKLYRSNPISHPMQVSQLAS 2508
Query: 2265 ALTQESCSVENLSKMYIGWL 2284
+L + + S E LS+MY+GW+
Sbjct: 2509 SLIELATSEEKLSEMYLGWM 2528
>SPBC216.07c [L] KOG0891 DNA-dependent protein kinase
Length = 1973
Score = 166 bits (421), Expect = 3e-40
Identities = 122/386 (31%), Positives = 183/386 (46%), Gaps = 60/386 (15%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
++ I +F + V S ++P++L++ GSDG Y + K ED+RQD + MQ + LL
Sbjct: 1588 VIRIVKFYPTFNVITSKQRPRRLSIKGSDGKDYQYVLKGHEDIRQDERVMQLFGLCNNLL 1647
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLK----- 2075
D E+ KR L I Y V+ L D GLL V + TL L+ ES KI +++
Sbjct: 1648 LADPETFKRLLSIQRYPVIPLSPDSGLLGWVLDSDTLHVLIRDYRESRKILLNIEHRLII 1707
Query: 2076 SLQEKWQSIPSDQKL-AFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAM 2134
+ + + QK+ F L LY+ W N R + R+ +VM+M
Sbjct: 1708 QMAPDYDRLTLLQKVEVFEYALLSTTGQDLYRVLWLKSRSSEAWLNRRTNYSRTLAVMSM 1767
Query: 2135 VGHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDAFGI 2193
VG+ILGLGDRH N++LD TG ++H+DF DC + PE +PFRLT+ + +A +
Sbjct: 1768 VGYILGLGDRHPSNLMLDRYTGNIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLVNAMEV 1827
Query: 2194 IGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKID--------------------- 2232
G EGTF+ + E +RV+R N+ ++ ++E +YD I+
Sbjct: 1828 SGIEGTFRITCEHVMRVLRTNKESVMAVLEAFVYDPLINWRLAPAYSPSIDEKQSNEPNT 1887
Query: 2233 ---ESI-------------------------QNALKVLR---DKIRGIDARDGLALSVSG 2261
E+I Q A+ VL +K+ G D + L V
Sbjct: 1888 LLGETIDGLHRKRLNEEGITLEERQKPEILNQRAITVLNRVSNKLTGRDFKPQQQLDVPS 1947
Query: 2262 QVEALTQESCSVENLSKMYIGWLPFW 2287
QVE L ++ S+ENL YIGW FW
Sbjct: 1948 QVEKLILQATSIENLCLCYIGWCSFW 1973
Score = 62.8 bits (151), Expect = 6e-09
Identities = 116/639 (18%), Positives = 241/639 (37%), Gaps = 78/639 (12%)
Query: 1291 KVLQVLDRTERFVN----TIPSD--TLAKKSLETDSFERSALYLEQSYREHGTSSLASTD 1344
+++Q+L F+ +P D TL + + +F ++ Y E + E + S D
Sbjct: 839 EIIQILLNLAEFMEHDDKPLPIDIRTLGAYAAKCHAFAKALHYKELEFIEEELVTKPSVD 898
Query: 1345 LLQCIQNTYAEIGDVDAVGGVLKMFSTGNLTTKIEELQYSK--NWKMAQDCFEALGDFKL 1402
++ + + ++ DA G+LK + ++E Y K W+ A +E K
Sbjct: 899 TIEALISINNQLQQPDAAIGILKHAQQHD-KMNLKETWYEKLQRWEDALSAYE-----KR 952
Query: 1403 SANSTTSSELVKSSNMKMLKSMYSHQLYEELLMKVKVHLPETKGFLVDNDGDLLNMGIEA 1462
A + E+ ++ L ++ +L + +H +D +
Sbjct: 953 EAAGAGNFEITMGK-LRCLHALGEWDRLSQLAQENWIH--------AGHDARRYIAPLSV 1003
Query: 1463 VSQTGNIVELTRWIERVEHIQMFNDPSLLLHYNIAKVLQAVSRNQQQNVERYINKCFTLI 1522
+ G L +W + E+I + S + A V A+ R+Q + YI + L+
Sbjct: 1004 AAAWG----LGQWEQMDEYISVMKSESPDKAFFNAIV--ALHRSQFEEAASYITRARDLL 1057
Query: 1523 GAQFT--IPSTSTTLLKNREVLQKLHALTDIKLLCSAHTQSEFSNA-SKALDGRLSHVGS 1579
+ T + + +Q L L +I A + E K RL
Sbjct: 1058 DTELTALVGESYNRAYSVAVRVQMLSELEEIITYKKAEDKPEVREMIKKTWVRRLKGCQR 1117
Query: 1580 DFSPNHYLLSIRKTVEIISKNQHLQNDISNVYFQLSQLDRKENRLDLAAEDLMN-----A 1634
+ +L IR V N + +N+ + ++ + L+L ED N
Sbjct: 1118 NVDVWQRMLRIRSLVISPRDNMEMWIKFANLCRKSGRISLAKKSLNLLLEDDENLDNSLV 1177
Query: 1635 LKYNHHSAELEFAEILWKQGEKDMALKTVAEITKRFKDD---------PSTASSENQDFK 1685
LK H S + LW +K AL ++ E T + D ST+ + + +
Sbjct: 1178 LKKTHPSIVYANLKFLWAVDDKRKALNSMQEFTSQLISDINVDPALFVQSTSVNTQKSQE 1237
Query: 1686 EVLL----------KYTEWLDLSNSSVSEQ----IIKQYNELIRFDKNWDAPFYSMGLYY 1731
E+ K +W ++ SE +++ Y +FD W ++S L
Sbjct: 1238 EIQYYFHLLARCYHKQGQWQQEIENNWSEGSFDGVLQSYMYATQFDSKWYKAWHSWALAN 1297
Query: 1732 SKLLE-KKKAEGYVSDGSLEYR---SITNFLTSFEKGSPNIRQSLPKVVTLWLDTAKXXX 1787
+ ++ +++E + + E ++ F S N++ +L +++ LW
Sbjct: 1298 FEAVKFLEQSEEQIPSAAYEQYIIPAVKGFFKSIALSKGNLQDTL-RLLNLWFKFGNNS- 1355
Query: 1788 XXXXXXXXXXXXRICNKIDTAVKNCGIHIWYTVLTQLLSRLMHPHTATIHTIVNILFHMT 1847
+ N ++ + I IW V+ QL++R+ + ++ +L +
Sbjct: 1356 ------------NVINTLNVGISTVNIDIWLDVIPQLIARIHASSLSVRKSVHQLLSDVG 1403
Query: 1848 LEYPSVMLWYISILLNSESLERRNIGKQIVEAFQKKNPR 1886
+P +++ +++ S+S R+N I+++ + +PR
Sbjct: 1404 RAHPQALVYPLTVAAKSQSSARQNAALAIMDSLKTHSPR 1442
>SPBC30D10.10c [L] KOG0891 DNA-dependent protein kinase
Length = 2335
Score = 161 bits (408), Expect = 1e-38
Identities = 115/389 (29%), Positives = 180/389 (45%), Gaps = 65/389 (16%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
++ I+ F + V +S ++P++LT+ GSDG Y + K ED+RQD + MQ + LL
Sbjct: 1949 VIRISHFHHTFEVISSKQRPRRLTIHGSDGKDYQYVLKGHEDLRQDERVMQLFGLCNTLL 2008
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEK 2080
+ D E+ KR L I Y V+ L + GLL VP+ TL L+ I +L+
Sbjct: 2009 TTDSETFKRRLNIERYTVIPLSPNSGLLGWVPHSDTLHFLIKEFRSKRNILLNLEHRMML 2068
Query: 2081 WQSIPSDQKLAFHKDCLKKFPPV--------LYQWFLDNFPDPITWYNARNGFVRSYSVM 2132
+ D K L+ F V LY W + R + +S +VM
Sbjct: 2069 QMAPDCDSLTLLQK--LEVFEYVMANTDGYDLYHVLWLKSRSSEAWLDRRTSYTQSLAVM 2126
Query: 2133 AMVGHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDAF 2191
+MVG+ILGLGDRH N+++D +G+++H+DF DC + PE +PFRLT+ + +A
Sbjct: 2127 SMVGYILGLGDRHPSNLMMDRYSGKIIHIDFGDCFEVAMHREKFPEKIPFRLTRMLINAM 2186
Query: 2192 GIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD-------------------RKID 2232
+ G +GT+K + E+ +RV+R+N L+ ++E +YD R
Sbjct: 2187 EVSGIQGTYKITCELVMRVLRSNTESLMAVLEAFVYDPLINWRLMTKSSFGASTTLRPTS 2246
Query: 2233 ESIQ----------------------------------NALKVLRDKIRGIDARDGLALS 2258
S++ LK + +K+ G D L
Sbjct: 2247 SSVEEKGRSYTHRARHADYAALSETNGVNAEGLNERSIQVLKRVSNKLTGKDFDLKEQLP 2306
Query: 2259 VSGQVEALTQESCSVENLSKMYIGWLPFW 2287
V QVE L Q++ + ENL + Y+GW FW
Sbjct: 2307 VKAQVEKLIQQATAPENLCRCYVGWCSFW 2335
>7297995 [L] KOG0891 DNA-dependent protein kinase
Length = 2470
Score = 155 bits (392), Expect = 7e-37
Identities = 94/301 (31%), Positives = 162/301 (53%), Gaps = 8/301 (2%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
++ I+ + V S ++P+KL + GS+G Y + K ED+RQD + MQ + ++ LL
Sbjct: 2071 LIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLL 2130
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYS-----LK 2075
D ++ +RNL I Y V+ L + GL+ VP+ TL +L+ + K+ + +
Sbjct: 2131 LDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTML 2190
Query: 2076 SLQEKWQSIPSDQKLAFHKDCLKKFP-PVLYQWFLDNFPDPITWYNARNGFVRSYSVMAM 2134
+ + + QK+ + L + L + P W+ RN + RS +VM+M
Sbjct: 2191 NFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSM 2250
Query: 2135 VGHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDAFGI 2193
VG+ILGLGDRH N++LD ++G++LH+DF DC + PE +PFRLT+ + A +
Sbjct: 2251 VGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEV 2310
Query: 2194 IGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKIDESIQNALKVLRDKIRGIDARD 2253
G EGT++++ E + V+R N+ L+ ++E +YD ++ + + K D + G A
Sbjct: 2311 TGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPG 2370
Query: 2254 G 2254
G
Sbjct: 2371 G 2371
>Hs4826730 [L] KOG0891 DNA-dependent protein kinase
Length = 2549
Score = 149 bits (376), Expect = 5e-35
Identities = 86/275 (31%), Positives = 152/275 (55%), Gaps = 8/275 (2%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
++ I + V S ++P+KLT++GS+G+ + + K ED+RQD + MQ ++ LL
Sbjct: 2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLL 2209
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKS---- 2076
+ D S ++NL I Y V+ L + GL+ VP+ TL +L+ E KI +++
Sbjct: 2210 ANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIML 2269
Query: 2077 -LQEKWQSIPSDQKLAFHKDCLKKFP-PVLYQWFLDNFPDPITWYNARNGFVRSYSVMAM 2134
+ + + QK+ + + L + P W++ R + RS +VM+M
Sbjct: 2270 RMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSM 2329
Query: 2135 VGHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDAFGI 2193
VG+ILGLGDRH N++LD L+G++LH+DF DC + PE +PFRLT+ +T+A +
Sbjct: 2330 VGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEV 2389
Query: 2194 IGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD 2228
G +G ++ + + V+R ++ ++ ++E +YD
Sbjct: 2390 TGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYD 2424
>Hs18765739 [L] KOG0891 DNA-dependent protein kinase
Length = 3657
Score = 147 bits (371), Expect = 2e-34
Identities = 93/324 (28%), Positives = 153/324 (46%), Gaps = 38/324 (11%)
Query: 1946 LPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCKK-EDVR 2004
+ +T ++ ++ V+I + + KPKKL +GSDG Y + K ED+
Sbjct: 2098 MTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLH 2157
Query: 2005 QDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMK 2064
D + MQF + ++ + + Y V L GL++ V L L +
Sbjct: 2158 LDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK-R 2216
Query: 2065 YESMKIKYSLKSLQEKWQS------IPSDQKLAFHK------------------------ 2094
++ + + Q+ +Q+ +P +L + K
Sbjct: 2217 WQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVM 2276
Query: 2095 -----DCLKKFPP-VLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCEN 2148
+ ++ PP +L + + P W+ + RS +VM+MVG+I+GLGDRH +N
Sbjct: 2277 KAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDN 2336
Query: 2149 ILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTL 2208
+L+D+ TG V+H+D++ FEKGK L VPE VPFR+TQNI A G+ G EG F+ S E L
Sbjct: 2337 VLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVL 2396
Query: 2209 RVMRNNEIGLVNIIETIMYDRKID 2232
+MR L+ ++E +YD +D
Sbjct: 2397 HIMRRGRETLLTLLEAFVYDPLVD 2420
>Hs14719394 [L] KOG0891 DNA-dependent protein kinase
Length = 3031
Score = 147 bits (371), Expect = 2e-34
Identities = 93/324 (28%), Positives = 153/324 (46%), Gaps = 38/324 (11%)
Query: 1946 LPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCKK-EDVR 2004
+ +T ++ ++ V+I + + KPKKL +GSDG Y + K ED+
Sbjct: 1472 MTNTEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLH 1531
Query: 2005 QDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMK 2064
D + MQF + ++ + + Y V L GL++ V L L +
Sbjct: 1532 LDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYK-R 1590
Query: 2065 YESMKIKYSLKSLQEKWQS------IPSDQKLAFHK------------------------ 2094
++ + + Q+ +Q+ +P +L + K
Sbjct: 1591 WQQREAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVM 1650
Query: 2095 -----DCLKKFPP-VLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCEN 2148
+ ++ PP +L + + P W+ + RS +VM+MVG+I+GLGDRH +N
Sbjct: 1651 KAVLEELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDN 1710
Query: 2149 ILLDVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTL 2208
+L+D+ TG V+H+D++ FEKGK L VPE VPFR+TQNI A G+ G EG F+ S E L
Sbjct: 1711 VLIDMTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVL 1770
Query: 2209 RVMRNNEIGLVNIIETIMYDRKID 2232
+MR L+ ++E +YD +D
Sbjct: 1771 HIMRRGRETLLTLLEAFVYDPLVD 1794
>At1g50030 [L] KOG0891 DNA-dependent protein kinase
Length = 2467
Score = 132 bits (332), Expect = 6e-30
Identities = 85/283 (30%), Positives = 149/283 (52%), Gaps = 34/283 (12%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
+V+I+ FS Q +V S ++P+KLT+ G+DG Y + K ED+RQD + MQ ++ LL
Sbjct: 2064 VVTISSFSRQLVVITSKQRPRKLTIHGNDGEDYAFLLKGHEDLRQDERVMQLFGLVNTLL 2123
Query: 2021 SKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYS-----LK 2075
++ +++L I Y V+ L + GL+ VPN TL L+ ++ KI + +
Sbjct: 2124 ENSRKTAEKDLSIQRYSVIPLSPNSGLIGWVPNCDTLHHLIREHRDARKIILNQENKHML 2183
Query: 2076 SLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMV 2135
S + ++P K+ ++++ L+N + ++ V
Sbjct: 2184 SFAPDYDNLPLIAKVE------------VFEYALENTEG---------------NDLSRV 2216
Query: 2136 GHILGLGDRHCENILLDVLTGRVLHVDF-DCLFEKGKKLPVPEIVPFRLTQNITDAFGII 2194
G+ILGLGDRH N++L +G++LH+DF DC + PE VPFRLT+ + A +
Sbjct: 2217 GYILGLGDRHPSNLMLHRYSGKILHIDFGDCFEASMNREKFPEKVPFRLTRMLVKAMEVS 2276
Query: 2195 GTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKIDESIQN 2237
G EG F+ + E ++V+R N+ ++ ++E ++D I+ + N
Sbjct: 2277 GIEGNFRSTCENVMQVLRTNKDSVMAMMEAFVHDPLINWRLFN 2319
>CE27869 [L] KOG0891 DNA-dependent protein kinase
Length = 2327
Score = 130 bits (328), Expect = 2e-29
Identities = 90/313 (28%), Positives = 148/313 (46%), Gaps = 47/313 (15%)
Query: 1962 MVSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLL 2020
+VSI+R + Q + + +PKKL +GSDG + K +ED+ D + MQF + +L
Sbjct: 1753 VVSISRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVML 1812
Query: 2021 SKDVESRKRNLGITT---YGVLSLREDCGLL----------------------------- 2048
++++ Y V+ L GL+
Sbjct: 1813 QPGKGKHRQSVAAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQATKK 1872
Query: 2049 --EIVPNVVT----LRSLLSMKYESMKIKYSLKSLQEKWQSIPSDQKLAFHKDCLKKFPP 2102
E VP + +++ + + KI S+ S + KW P++ + K P
Sbjct: 1873 NGETVPEIERPSNMYHNMIRLAFADHKIDSSITSDRSKW---PAEILEEVFESLTAKTPT 1929
Query: 2103 VLYQ---WFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVL 2159
L W N D TW++ + RS +VM+MVG +LGLGDRH +N+L+D+ G V+
Sbjct: 1930 DLISRELWMRAN--DATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHVV 1987
Query: 2160 HVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLV 2219
H+D++ F+KGK L +PE VPFRLT+N+ A G GTF++S L +R+ L
Sbjct: 1988 HIDYNICFDKGKNLRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQVLT 2047
Query: 2220 NIIETIMYDRKID 2232
+++ ++D +D
Sbjct: 2048 MLLDAFVFDPLVD 2060
>CE22176 [TBLD] KOG0892 Protein kinase ATM/Tel1 involved in telomere length
regulation and DNA repair
Length = 759
Score = 120 bits (300), Expect = 3e-26
Identities = 110/472 (23%), Positives = 222/472 (46%), Gaps = 46/472 (9%)
Query: 1816 IWYTVLTQLLSRLMHPHTATI-HTIVNILFHMTLEYPSVMLWYISILLNSESLER-RNIG 1873
+W + + + S+ + I + IL H+ +YP +L I + + ++ + +
Sbjct: 159 LWISATSHIASKCFSIEKSQITRHLSQILCHLIYDYPYHVLHTILMYDDEKNASKVKGFL 218
Query: 1874 KQIVEAFQKKNPRTKLPGTAISLV---QSLTRVCIKDVKNTASRSGRSIDSDFKFNLELA 1930
K I +A + +KL I++ Q+ + + DV+ I+ +
Sbjct: 219 KTIFDARADQRDSSKLKEIVITIREAHQAYREIAMLDVRGNVRIQRVEINGKTMYRW--- 275
Query: 1931 PNDMCVPVNINLKKL-LPSTATSMN--SDLFKSVMVSIARFSSQYMVFNSLKKPKKLTVI 1987
P+D+ + L++L +P+ + + D + +++ R+ + + + + PK +
Sbjct: 276 PHDLKI-FKCKLRQLPIPTISQKIGCPGDYSTTDLITWKRWKDVFTIADGISTPKIWEIE 334
Query: 1988 GSDGNIYGIMCKKEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGL 2047
GSDG Y + KK+DVRQD Q + + +L K + + TY V+ L +CG+
Sbjct: 335 GSDGKWYKTVWKKDDVRQDVLVEQMFDVTNNMLEKAM--------LRTYNVVPLDTECGV 386
Query: 2048 LEIVPNVVTLRSL---------LSMKYESMKIKYS-LKSLQEKWQSIPSDQKLAFHKDCL 2097
+E V+L+ + L ++ S ++ S + S+ + Q+ ++ + +
Sbjct: 387 IEFCGGTVSLKEVMCGVTREGGLHREFNSEEVSASKVSSMMRQVQTESTETRRQVFVEIC 446
Query: 2098 KKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGR 2157
+++ PV +F NF W + +S + ++V +I+GLGDRH NIL D
Sbjct: 447 QQYSPVFRHFFYTNFSTAQIWRQKIINYRQSLATWSIVCYIVGLGDRHASNILFDQKLCT 506
Query: 2158 VLHVDFDCLFEKGKK-LPVPEIVPFRLTQNITDAFGIIGTEG--TFKKSSEVTLRVMRNN 2214
+H+D + E K+ LPVPE VPFR+T+++ D I G E ++ +++ ++ N
Sbjct: 507 FVHIDLGMILEYSKRTLPVPEQVPFRITRDVLDPILIEGIENGQLAEECTQIMEKLKENG 566
Query: 2215 EI--GLVNII--ETIMYDRKIDESI-------QNALKVLRDKIRGIDARDGL 2255
++ G+ + + ET+ R+ +++ + A+ LR+K+RG D DGL
Sbjct: 567 KVILGVASALLRETMTNFREAEQAAGRPSYISEMAIGRLREKLRGTD--DGL 616
>7290761 [L] KOG0891 DNA-dependent protein kinase
Length = 2162
Score = 102 bits (254), Expect = 7e-21
Identities = 79/268 (29%), Positives = 129/268 (47%), Gaps = 34/268 (12%)
Query: 1963 VSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCK-KEDVRQDNQYMQFANTMSFLLS 2021
V I S V + KPKK+ GS+G Y + K ED+ D + MQF + + +++
Sbjct: 1892 VYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMA 1951
Query: 2022 KDVESRKRNL-GITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEK 2080
++ Y V+ L GL+ V V + +L K++ + + + +
Sbjct: 1952 CRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYK-KWQQRRSQVAGNAGAGA 2010
Query: 2081 WQSIPS----------DQKLAFHK----DCLKKFPPVLYQWFLDNF----PDPIT----W 2118
++P LA H D +++P + LD P+ + W
Sbjct: 2011 VANVPRRFTDLFYNKLSPLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELW 2070
Query: 2119 YNARNG---------FVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEK 2169
A N FVR SVM+M+G+++GLGDRH +N+L+++ +G ++H+D++ FEK
Sbjct: 2071 CQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEK 2130
Query: 2170 GKKLPVPEIVPFRLTQNITDAFGIIGTE 2197
G+ L +PE VPFRLTQN+ A GI G E
Sbjct: 2131 GRTLRIPEKVPFRLTQNLVQAMGITGIE 2158
>Hs13654237 [L] KOG0891 DNA-dependent protein kinase
Length = 4128
Score = 99.0 bits (245), Expect = 8e-20
Identities = 78/296 (26%), Positives = 136/296 (45%), Gaps = 26/296 (8%)
Query: 1963 VSIARFSSQYMVFNSLKKPKKLTVIGSDGNIYGIMCKK-EDVRQDNQYMQFANTMSFLLS 2021
V IA F + V SL++PK++ + G D + + K ED+RQD + Q M+ +L+
Sbjct: 3717 VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILA 3776
Query: 2022 KDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLL--SMKYE------------- 2066
+D +R L + TY V+ + GL+E + N VTL+ LL +M E
Sbjct: 3777 QDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPP 3836
Query: 2067 --------SMKIKYSLKSLQEKWQSIPSDQKLAFHKDCLKKFP-PVLYQWFLDNFPDPIT 2117
M K+ + + ++ + + + K P +L + F+ P
Sbjct: 3837 CEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEA 3896
Query: 2118 WYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKK-LPVP 2176
+ R+ F S++++ + ILG+GDRH N ++ + TG V+ +DF F + LPVP
Sbjct: 3897 FLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVP 3956
Query: 2177 EIVPFRLTQNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKID 2232
E++PFRLT+ + + G LR R++ L N ++ + + D
Sbjct: 3957 ELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFD 4012
>CE24760 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 650
Score = 65.5 bits (158), Expect = 1e-09
Identities = 97/420 (23%), Positives = 182/420 (43%), Gaps = 80/420 (19%)
Query: 1839 IVNILFHMTLEYPSV---MLWYISILLNS--ESLER-----RNIGKQIVEAFQKKNPRTK 1888
+ L L P V + W++ + S ES E +NI +++EA K+ P T+
Sbjct: 230 LATFLIDYALASPKVSNYLYWHLKTEIESTKESKEEHSKMYQNIQDRLMEALVKR-PDTR 288
Query: 1889 LPGTAISLVQSLTRVCIKDVKNTASRSGR---SIDSDF-------KFNLELAPNDMCVPV 1938
++ Q I + +R GR S ++F K L+L + +
Sbjct: 289 AQVDSLHQQQIFVEDLIILMNEAKARGGRLNESKSAEFRTMLSRAKHMLDLKGVHLPLDP 348
Query: 1939 NINLKKLLPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKK---PKKLTVIGSDGNIYG 1995
+ L ++P TA+ FKS M+ A+ S + + N P++ TVI G
Sbjct: 349 SFRLSSVIPDTAS-----FFKSEMMP-AKISFKVLQPNGKADRNIPEEYTVIFKTG---- 398
Query: 1996 IMCKKEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVV 2055
+D+RQD Q + +L K + +L +T Y VLS G ++ + +
Sbjct: 399 -----DDLRQDQLIQQMVRLIDIILKKG----QLDLKLTPYLVLSTGVGQGFVQCIKSK- 448
Query: 2056 TLRSLLSMKYESMKIKYSLKSLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWFLDNFPDP 2115
L+++QE++++ K+ ++ +K+ P + ++
Sbjct: 449 -----------------PLRAIQEQYKA----HKMDCIREAMKELRPGDGPFGIEP---- 483
Query: 2116 ITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPV 2175
N + +VRS + +++ +ILGLGDRH +N+LL G++ HVDF + + K P+
Sbjct: 484 ----NVIDNYVRSLAGYSVIMYILGLGDRHLDNLLL-CENGKLFHVDFGFILGRDPK-PM 537
Query: 2176 PEIVPFRLTQNITDAFGIIGTEG--TFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKIDE 2233
P P +LT + G + ++ F + + R++R + L+N+ ++M D I +
Sbjct: 538 PP--PMKLTSEMVQVMGGVKSKQFLEFVQHVDSAYRILRRHSNVLLNLF-SLMLDAGIPD 594
>CE24759 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 901
Score = 65.5 bits (158), Expect = 1e-09
Identities = 97/420 (23%), Positives = 182/420 (43%), Gaps = 80/420 (19%)
Query: 1839 IVNILFHMTLEYPSV---MLWYISILLNS--ESLER-----RNIGKQIVEAFQKKNPRTK 1888
+ L L P V + W++ + S ES E +NI +++EA K+ P T+
Sbjct: 481 LATFLIDYALASPKVSNYLYWHLKTEIESTKESKEEHSKMYQNIQDRLMEALVKR-PDTR 539
Query: 1889 LPGTAISLVQSLTRVCIKDVKNTASRSGR---SIDSDF-------KFNLELAPNDMCVPV 1938
++ Q I + +R GR S ++F K L+L + +
Sbjct: 540 AQVDSLHQQQIFVEDLIILMNEAKARGGRLNESKSAEFRTMLSRAKHMLDLKGVHLPLDP 599
Query: 1939 NINLKKLLPSTATSMNSDLFKSVMVSIARFSSQYMVFNSLKK---PKKLTVIGSDGNIYG 1995
+ L ++P TA+ FKS M+ A+ S + + N P++ TVI G
Sbjct: 600 SFRLSSVIPDTAS-----FFKSEMMP-AKISFKVLQPNGKADRNIPEEYTVIFKTG---- 649
Query: 1996 IMCKKEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVV 2055
+D+RQD Q + +L K + +L +T Y VLS G ++ + +
Sbjct: 650 -----DDLRQDQLIQQMVRLIDIILKKG----QLDLKLTPYLVLSTGVGQGFVQCIKSK- 699
Query: 2056 TLRSLLSMKYESMKIKYSLKSLQEKWQSIPSDQKLAFHKDCLKKFPPVLYQWFLDNFPDP 2115
L+++QE++++ K+ ++ +K+ P + ++
Sbjct: 700 -----------------PLRAIQEQYKA----HKMDCIREAMKELRPGDGPFGIEP---- 734
Query: 2116 ITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPV 2175
N + +VRS + +++ +ILGLGDRH +N+LL G++ HVDF + + K P+
Sbjct: 735 ----NVIDNYVRSLAGYSVIMYILGLGDRHLDNLLL-CENGKLFHVDFGFILGRDPK-PM 788
Query: 2176 PEIVPFRLTQNITDAFGIIGTEG--TFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKIDE 2233
P P +LT + G + ++ F + + R++R + L+N+ ++M D I +
Sbjct: 789 PP--PMKLTSEMVQVMGGVKSKQFLEFVQHVDSAYRILRRHSNVLLNLF-SLMLDAGIPD 845
>YLR240w [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 875
Score = 63.9 bits (154), Expect = 3e-09
Identities = 75/279 (26%), Positives = 120/279 (42%), Gaps = 49/279 (17%)
Query: 1974 VFNSLKKPKKLTVIGSDGNIYGIMCKK-EDVRQDNQYMQFANTMSFLLSKDVESRKRNLG 2032
VF S P K+T + Y +M K +D+RQD +Q + M+ LL + +L
Sbjct: 599 VFKSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNE----NVDLK 654
Query: 2033 ITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEKWQSIPSDQKLAF 2092
+T Y +L+ G +E +PN TL S+LS K+ I KL +
Sbjct: 655 LTPYKILATGPQEGAIEFIPND-TLASILS-----------------KYHGILGYLKLHY 696
Query: 2093 HKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLD 2152
+ + W LDNF V+S + ++ +ILG+GDRH +N+L+
Sbjct: 697 PDE---NATLGVQGWVLDNF-------------VKSCAGYCVITYILGVGDRHLDNLLV- 739
Query: 2153 VLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFGIIGTEGT----FKKSSEVTL 2208
G H DF + + K P P ++ +L I +AFG G E + F+ V
Sbjct: 740 TPDGHFFHADFGYILGQDPK-PFPPLM--KLPPQIIEAFG--GAESSNYDKFRSYCFVAY 794
Query: 2209 RVMRNNEIGLVNIIETIMYDRKIDESIQNALKVLRDKIR 2247
++R N ++N+ E + D I +LR + R
Sbjct: 795 SILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRER 833
>CE05832 [T] KOG0905 Phosphoinositide 3-kinase
Length = 1607
Score = 63.9 bits (154), Expect = 3e-09
Identities = 50/190 (26%), Positives = 86/190 (44%), Gaps = 34/190 (17%)
Query: 1974 VFNSLKKPKKLTVIGSDGNIYGIMCKKEDVRQDNQYMQFANTMSFLLSKDVESRKRNLGI 2033
VFNS KP K+ G + N I + +D+RQD M+ N M + +S +L +
Sbjct: 1035 VFNSNAKPLKIVFRGLNMNYSIIHKRDDDMRQDAFVMKMLNEMDRIW----KSNGLDLRM 1090
Query: 2034 TTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEKWQSIPSDQKLAFH 2093
T+ ++ + G+ E+V N TL + +E + + +D+
Sbjct: 1091 ITFRIMPVGYRRGMGELVLNCATLMEIQK---------------EEGLRGVLNDE----- 1130
Query: 2094 KDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDV 2153
+L +W + + D + A+ F+RS + +V ++LG+GDRH +NIL
Sbjct: 1131 ---------ILRKWLMKHNSDEFAYKEAQENFIRSCAGWCIVTYVLGIGDRHNDNILF-T 1180
Query: 2154 LTGRVLHVDF 2163
G V H+DF
Sbjct: 1181 KNGHVFHIDF 1190
>At1g60490 [TU] KOG0906 Phosphatidylinositol 3-kinase VPS34 involved in signal
transduction
Length = 814
Score = 61.2 bits (147), Expect = 2e-08
Identities = 62/221 (28%), Positives = 102/221 (46%), Gaps = 44/221 (19%)
Query: 1974 VFNSLKKPKKLTVIGSD--GNIYGIMCKKEDVRQDNQYMQFANTMSFLLSKDVESRKRNL 2031
+F S P +LT + G+ I K +D+RQD +Q M +L+ + ++ +L
Sbjct: 538 LFKSALHPLRLTFRTPEEGGSCKLIFKKGDDLRQDQLVVQ----MVWLMDRLLKLENLDL 593
Query: 2032 GITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSLQEKWQSIPSDQKLA 2091
+T Y VL+ D G+LE +P+ RSL + E I L+
Sbjct: 594 CLTPYKVLATGHDEGMLEFIPS----RSLAQILSEHRSITSYLQK--------------- 634
Query: 2092 FHKDCLKKFPPVLYQWFLDNFPDPITWYNARNGFVRSYSVMAMVGHILGLGDRHCENILL 2151
FH D ++ P IT + F++S + +++ +ILG+GDRH +N+LL
Sbjct: 635 FHPD--------------EHAPFGIT-ATCLDTFIKSCAGYSVITYILGIGDRHLDNLLL 679
Query: 2152 DVLTGRVLHVDFDCLFEKGKKLPVPEIVPFRLTQNITDAFG 2192
GR+ HVDF + + K P P P +L + + +A G
Sbjct: 680 -TDDGRLFHVDFAFILGRDPK-PFPP--PMKLCKEMVEAMG 716
>Hs4507691 [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1 component
PI-3 kinase superfamily
Length = 3830
Score = 60.5 bits (145), Expect = 3e-08
Identities = 78/366 (21%), Positives = 148/366 (40%), Gaps = 43/366 (11%)
Query: 1963 VSIARFSSQYMVFNSLKKP-KKLTVIGSDGNIYGIMCKKE----DVRQDNQYMQFANTMS 2017
+ IARF + + ++L + G +G IY + + + R++ + +Q ++
Sbjct: 3465 IKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLLRLLN 3524
Query: 2018 FLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYS--LK 2075
L K E+ KR+L T V+++ L+E P+ ++L + + I++ +
Sbjct: 3525 PCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGIEHDNPIS 3584
Query: 2076 SLQEKWQSIPSDQKLAFH---KDCLKKFPP------VLYQWFLDNFPDPITWYNARNGFV 2126
++ ++ + A H +D LK+ +L +W L FP+ ++ R F
Sbjct: 3585 RYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSMLKEWALHTFPNATDYWTFRKMFT 3644
Query: 2127 RSYSVMAMVGHILGLGDRHCENILLDVLTGR--VLHVDFDCLFEKGKKLPVPEIVPFRLT 2184
+++ +L L + E + + TG+ V + FD G L VPFRLT
Sbjct: 3645 IQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGD-LDANRPVPFRLT 3703
Query: 2185 QNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYD------RKIDESI--- 2235
NI++ IG G S R + I++T++ D +K E
Sbjct: 3704 PNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKKTQEDTSSP 3763
Query: 2236 ------------QNALKVLRDKIRGIDAR-DGLALSVSGQ--VEALTQESCSVENLSKMY 2280
Q + +++ + I R LA G+ V L + S++NL +M
Sbjct: 3764 LSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAANSLDNLCRMD 3823
Query: 2281 IGWLPF 2286
W P+
Sbjct: 3824 PAWHPW 3829
>7302249 [TBLD] KOG0889 Histone acetyltransferase SAGA TRRAP/TRA1 component
PI-3 kinase superfamily
Length = 3435
Score = 60.1 bits (144), Expect = 4e-08
Identities = 74/371 (19%), Positives = 148/371 (38%), Gaps = 51/371 (13%)
Query: 1963 VSIARFSSQY-MVFNSLKKPKKLTVIGSDGNIYGIMCKKE----DVRQDNQYMQFANTMS 2017
V IARF + +V + ++L + G++G IY + + D R++ + +Q ++
Sbjct: 3068 VRIARFMPRVEIVQKNNTAARRLYIRGTNGKIYPYLVVLDSGLGDARREERVLQLKRMLN 3127
Query: 2018 FLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSLLSMKYESMKIKYSLKSL 2077
+ L K E+ +R L IT V+ + L E PN ++L + +SM++ Y + +
Sbjct: 3128 YYLEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISLLKIFKKCCQSMQVDYDMPIV 3187
Query: 2078 Q--EKWQSIPSDQKLAFHKDCLKKFPPV---------LYQWFLDNFPDPITWYNARNGFV 2126
+ ++ + + H + F + L W L F +++ R
Sbjct: 3188 KYYDRLSEVQARGTPTTHTLLREIFSEIQWTMVPKTLLKHWALKTFLAATDFWHFRKMLT 3247
Query: 2127 RSYSVMAMVGHILGLGDRHCENILLDVLTG--RVLHVDFDCLFEKGKKLPVPEIVPFRLT 2184
++ + H L L + + + L +G + + FD +K +L VPFRLT
Sbjct: 3248 LQLALAFLCEHALNLTRLNADMMYLHQDSGLMNISYFKFDVNDDK-CQLNQHRPVPFRLT 3306
Query: 2185 QNITDAFGIIGTEGTFKKSSEVTLRVMRNNEIGLVNIIETIMYDR------------KID 2232
N+ + G G + T R L +I++TI+ D K+
Sbjct: 3307 PNVGEFITHFGITGPLSAAIVATARCFIQPNYKLSSILQTILRDEIIALQKKGFRECKLI 3366
Query: 2233 ES-----------------IQNALKVLRDKIRGIDARDGLALSVSGQVEALTQESCSVEN 2275
E + +A+ ++ + I D + + ++ L Q + +++N
Sbjct: 3367 EGSEDRYSDGNCMEHSVNIVNSAVDIIMTRFNKISYFDSIE---NKKISVLVQSATNIDN 3423
Query: 2276 LSKMYIGWLPF 2286
L +M W P+
Sbjct: 3424 LCRMDPAWHPW 3434
>CE04513 [TU] KOG0903 Phosphatidylinositol 4-kinase involved in intracellular
trafficking and secretion
Length = 604
Score = 55.1 bits (131), Expect = 1e-06
Identities = 39/138 (28%), Positives = 67/138 (48%), Gaps = 8/138 (5%)
Query: 2117 TWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGKKLPVP 2176
T+ NA+ F++S + ++V + L L DRH NILLD + G ++H+D+ L +
Sbjct: 432 TYVNAQKNFIQSTAAYSLVSYYLQLKDRHNGNILLD-MDGHLIHIDYGFLLSSSPRNLGF 490
Query: 2177 EIVPFRLTQNITDAFGIIGTEG--TFKKSSEVTLRVMRNNEIGLVNIIETIMYDRKIDES 2234
E PF+LT I D G I ++ FK L R + +V++ E + K+
Sbjct: 491 ETAPFKLTTEIIDVMGGIDSDMFLYFKSLLLRGLMAARKHHRRIVSLAEIMSAGSKM--- 547
Query: 2235 IQNALKVLRDKIRGIDAR 2252
+ + +R ++AR
Sbjct: 548 --QCFRAGAETVRALEAR 563
>YLR305c [T] KOG0902 Phosphatidylinositol 4-kinase
Length = 1900
Score = 53.5 bits (127), Expect = 4e-06
Identities = 32/91 (35%), Positives = 50/91 (54%), Gaps = 3/91 (3%)
Query: 2104 LYQWFLDNFPDPIT--WYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHV 2161
LY++F F + T + NARN FV+S + +++ ++L DRH NI+ D G LH+
Sbjct: 1713 LYEYFTSKFGNESTIEFQNARNNFVKSLAGYSVISYLLQFKDRHNGNIMYDD-QGHCLHI 1771
Query: 2162 DFDCLFEKGKKLPVPEIVPFRLTQNITDAFG 2192
DF +F+ E VPF+LT+ + G
Sbjct: 1772 DFGFIFDIVPGGIKFEAVPFKLTKEMVKVMG 1802
>CE23506 [T] KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110)
Length = 1146
Score = 52.8 bits (125), Expect = 7e-06
Identities = 49/192 (25%), Positives = 92/192 (47%), Gaps = 15/192 (7%)
Query: 2001 EDVRQDNQYMQFANTMSFLLSKDVESRKRNLGITTYGVLSLREDCGLLEIVPNVVTLRSL 2060
+D+RQD +Q M + ++ + + Y VL + E G++E+VPN T+ +
Sbjct: 857 DDLRQDMLVLQVLEVMDNIW----KAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEI 912
Query: 2061 -LSMKYESMKIKYSLKSLQEKW---QSIPSDQKLAFHKDCLKKFPPVLYQWFLDNFPDPI 2116
+ + + ++ S KW Q D+K KD K P+ + +DN
Sbjct: 913 QVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKN--PI--EKKIDNTQAMK 968
Query: 2117 TWYNARNGFVRSYSVMAMVGHILGLGDRHCENILLDVLTGRVLHVDFDCLFEKGK-KLPV 2175
++ + + F+ S ++ +I+G+ DRH +N++L G+ H+DF + GK KL +
Sbjct: 969 KYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLML-TEDGKYFHIDFGHILGHGKTKLGI 1027
Query: 2176 P-EIVPFRLTQN 2186
+ PF LT++
Sbjct: 1028 QRDRQPFILTEH 1039
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.135 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 126,985,716
Number of Sequences: 60738
Number of extensions: 5247645
Number of successful extensions: 14651
Number of sequences better than 1.0e-05: 40
Number of HSP's better than 0.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 14394
Number of HSP's gapped (non-prelim): 159
length of query: 2287
length of database: 30,389,216
effective HSP length: 123
effective length of query: 2164
effective length of database: 22,918,442
effective search space: 49595508488
effective search space used: 49595508488
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)