ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4039 good O KOG1498 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN5/PSMD12
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4039 1427194 1425872 -441
(441 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL147w [O] KOG1498 26S proteasome regulatory complex subunit RP... 678 0.0
Hs4506221 [O] KOG1498 26S proteasome regulatory complex subunit ... 380 e-105
SPAPB8E5.02c [O] KOG1498 26S proteasome regulatory complex subun... 364 e-100
SPAC1420.03 [O] KOG1498 26S proteasome regulatory complex subuni... 364 e-100
CE02632 [O] KOG1498 26S proteasome regulatory complex subunit RP... 309 6e-84
At5g09900 [O] KOG1498 26S proteasome regulatory complex subunit ... 297 2e-80
At5g64760 [O] KOG1498 26S proteasome regulatory complex subunit ... 291 1e-78
7296672 [O] KOG1498 26S proteasome regulatory complex subunit RP... 264 2e-70
ECU05g1080 [O] KOG1498 26S proteasome regulatory complex subunit... 121 2e-27
Hs18554904 [O] KOG1498 26S proteasome regulatory complex subunit... 88 2e-17
7304120 [OT] KOG1497 COP9 signalosome subunit CSN4 78 3e-14
Hs7705845 [OT] KOG1497 COP9 signalosome subunit CSN4 71 3e-12
Hs22043519 [O] KOG1498 26S proteasome regulatory complex subunit... 70 8e-12
At5g42970 [OT] KOG1497 COP9 signalosome subunit CSN4 62 2e-09
>YDL147w [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 445
Score = 678 bits (1749), Expect = 0.0
Identities = 341/445 (76%), Positives = 394/445 (87%), Gaps = 4/445 (0%)
Query: 1 MSRDAPIKAEKDYTEILDAEFPKLEILAKNDYSSALDQLLVLEKKTRQSSDLASSKRVLT 60
MSRDAPIKA+KDY++IL EFPK++ LA+ND +SALDQLLVLEKKTRQ+SDLASSK VL
Sbjct: 1 MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLA 60
Query: 61 KIVDVLVAADQWDLLNDQIMLLSKKHGQLKLSVQYMIQSVMKYLEDLK--DLDTKIKTIE 118
KIVD+L + ++WD LN+Q+ LLSKKHGQLKLS+QYMIQ VM+YL+ K DL+T+I IE
Sbjct: 61 KIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIE 120
Query: 119 TIRTVTENKIFVEVERARVTRDLVHIRRSENKIDEATDLLCELQVETYGSMEMYEKIEFI 178
TIR VTENKIFVEVERARVT+DLV I++ E KIDEA D+LCELQVETYGSMEM EKI+FI
Sbjct: 121 TIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFI 180
Query: 179 LEQMELSILKGDYSQATVLSRKILKKTFKNEKYAALKLEYYNLLVKIGLHKKDYLEVAQY 238
LEQMELSILKGDYSQATVLSRKILKKTFKN KY +LKLEYYNLLVKI LHK++YLEVAQY
Sbjct: 181 LEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQY 240
Query: 239 YQEIYNSDSVKADEIQWKAALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLV 298
QEIY +D++K+DE +WK LS +VYFL+LSPY NLQNDLIHK+Q DNNLKKL SQESLV
Sbjct: 241 LQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLIHKIQNDNNLKKLESQESLV 300
Query: 299 KLFTTAELMRWPIVQDTYKEILNQDGVAFG--SNESHWEDLHKRIIEHNLRVISKYYTKI 356
KLFTT ELMRWPIVQ TY+ +LN+D +AFG +N+ HWEDL KR+IEHNLRVIS+YY++I
Sbjct: 301 KLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRI 360
Query: 357 TLPRLKELLDLDEAKTESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVD 416
TL RL ELLDL E++TE++ISDLVNQGIIYAK+NRP KIVNF KP NSS LLNEWS NVD
Sbjct: 361 TLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVD 420
Query: 417 QLLDHIETIGHLITKEEIMHGLKAK 441
+LL+HIETIGHLITKEEIMHGL+AK
Sbjct: 421 ELLEHIETIGHLITKEEIMHGLQAK 445
>Hs4506221 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 456
Score = 380 bits (976), Expect = e-105
Identities = 187/443 (42%), Positives = 293/443 (65%), Gaps = 10/443 (2%)
Query: 7 IKAEKDYTEILDAEFPKLEILAKND-YSSALDQLLVLEKKTRQSSDLASSKRVLTKIVDV 65
+K E DY+ +D P+ LAK ++ LL LEK+TR +SD+ S+ R+L +V +
Sbjct: 14 VKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKM 73
Query: 66 LVAADQWDLLNDQIMLLSKKHGQLKLSVQYMIQSVMKYLEDLKDLDTKIKTIETIRTVTE 125
A +WDLLN+ IMLLSK+ QLK +V M+Q Y+E++ DL K++ I+T+R VTE
Sbjct: 74 CYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTE 133
Query: 126 NKIFVEVERARVTRDLVHIRRSENKIDEATDLLCELQVETYGSMEMYEKIEFILEQMELS 185
KI+VE+ERAR+T+ L I+ + EA +L ELQVETYGSME E++EFILEQM L
Sbjct: 134 GKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLC 193
Query: 186 ILKGDYSQATVLSRKILKKTFKNEKYAALKLEYYNLLVKIGLHKKDYLEVAQYYQEIYNS 245
+ DY + ++S+KI K F+ E LKL+YYNL++++ H+ YL + ++Y+ IY++
Sbjct: 194 LAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDT 253
Query: 246 DSVKADEIQWKAALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVKLFTTAE 305
++A+ +W+ AL VV ++IL+P+DN Q+DL+H++ D L+++P + L+KLFTT E
Sbjct: 254 PCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTME 313
Query: 306 LMRWPIVQDTYKEILNQDGV------AFGS---NESHWEDLHKRIIEHNLRVISKYYTKI 356
LMRW + + Y L + + FGS E W+DL R++EHN+R+++KYYT+I
Sbjct: 314 LMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRI 373
Query: 357 TLPRLKELLDLDEAKTESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVD 416
T+ R+ +LLDL ++E+F+S+LV I+AK++R I+NF +P + ++LLN+WS ++
Sbjct: 374 TMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLN 433
Query: 417 QLLDHIETIGHLITKEEIMHGLK 439
L+ + HLI KEE++H L+
Sbjct: 434 SLMSLVNKTTHLIAKEEMIHNLQ 456
>SPAPB8E5.02c [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 443
Score = 364 bits (935), Expect = e-100
Identities = 187/436 (42%), Positives = 278/436 (62%), Gaps = 5/436 (1%)
Query: 8 KAEKDYTEILDAEFPKLEILAKNDYSSALDQLLVLEKKTRQSSDLASSKRVLTKIVDVLV 67
K E DY+E L L D + L++LL+ EK+ RQ+SD +++ +VL I D+L
Sbjct: 4 KPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLF 63
Query: 68 AADQWDLLNDQIMLLSKKHGQLKLSVQYMIQSVMKYLEDLKDLDTKIKTIETIRTVTENK 127
A + LN+Q++ L KKHGQLK S+ ++Q VM YL + DL TKI IET+RT+T+ K
Sbjct: 64 RAGDFQGLNEQLVSLFKKHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGK 123
Query: 128 IFVEVERARVTRDLVHIRRSENKIDEATDLLCELQVETYGSMEMYEKIEFILEQMELSIL 187
I+VEVERAR+T+ L I+ + I A ++LC VETYGS ++ EK+ FIL+Q+ L +L
Sbjct: 124 IYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVETYGSFDLKEKVAFILDQVRLFLL 183
Query: 188 KGDYSQATVLSRKILKKTFKNEKYAALKLEYYNLLVKIGLHKKDYLEVAQYYQEIYNSDS 247
+ DY A+ ++KI K F+ E +LKL+YY ++IGLH YL+V +YY+ +Y++
Sbjct: 184 RSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAV 243
Query: 248 VKADEIQWKAALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVKLFTTAELM 307
V+ D +WK L VV F +L+PYDN Q DL+H++ D+ L LP + LVK F ELM
Sbjct: 244 VQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELM 303
Query: 308 RWPIVQDTYKEILNQDGVAFGSN----ESHWEDLHKRIIEHNLRVISKYYTKITLPRLKE 363
RWP + + Y L + V F N E W +L KR+IEHN+RV++ YY++I RL
Sbjct: 304 RWPKIAEIYGSALRSNPV-FAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGV 362
Query: 364 LLDLDEAKTESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVDQLLDHIE 423
LLD+ ++TE F+ DL+ + YAKI+RP ++++F K N + LNEW +N+ +LL +E
Sbjct: 363 LLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNITELLGKLE 422
Query: 424 TIGHLITKEEIMHGLK 439
+ LI KEE+M+ ++
Sbjct: 423 KVRQLIIKEEMMNSIQ 438
>SPAC1420.03 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 443
Score = 364 bits (935), Expect = e-100
Identities = 187/436 (42%), Positives = 278/436 (62%), Gaps = 5/436 (1%)
Query: 8 KAEKDYTEILDAEFPKLEILAKNDYSSALDQLLVLEKKTRQSSDLASSKRVLTKIVDVLV 67
K E DY+E L L D + L++LL+ EK+ RQ+SD +++ +VL I D+L
Sbjct: 4 KPEVDYSEKFAELQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLF 63
Query: 68 AADQWDLLNDQIMLLSKKHGQLKLSVQYMIQSVMKYLEDLKDLDTKIKTIETIRTVTENK 127
A + LN+Q++ L KKHGQLK S+ ++Q VM YL + DL TKI IET+RT+T+ K
Sbjct: 64 RAGDFQGLNEQLVSLFKKHGQLKQSMTSLVQHVMTYLPGIDDLKTKINLIETLRTITDGK 123
Query: 128 IFVEVERARVTRDLVHIRRSENKIDEATDLLCELQVETYGSMEMYEKIEFILEQMELSIL 187
I+VEVERAR+T+ L I+ + I A ++LC VETYGS ++ EK+ FIL+Q+ L +L
Sbjct: 124 IYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVETYGSFDLKEKVAFILDQVRLFLL 183
Query: 188 KGDYSQATVLSRKILKKTFKNEKYAALKLEYYNLLVKIGLHKKDYLEVAQYYQEIYNSDS 247
+ DY A+ ++KI K F+ E +LKL+YY ++IGLH YL+V +YY+ +Y++
Sbjct: 184 RSDYYMASTYTKKINVKFFEKEDVQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAV 243
Query: 248 VKADEIQWKAALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVKLFTTAELM 307
V+ D +WK L VV F +L+PYDN Q DL+H++ D+ L LP + LVK F ELM
Sbjct: 244 VQEDPEKWKEILENVVCFALLTPYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELM 303
Query: 308 RWPIVQDTYKEILNQDGVAFGSN----ESHWEDLHKRIIEHNLRVISKYYTKITLPRLKE 363
RWP + + Y L + V F N E W +L KR+IEHN+RV++ YY++I RL
Sbjct: 304 RWPKIAEIYGSALRSNPV-FAENDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGV 362
Query: 364 LLDLDEAKTESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVDQLLDHIE 423
LLD+ ++TE F+ DL+ + YAKI+RP ++++F K N + LNEW +N+ +LL +E
Sbjct: 363 LLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNITELLGKLE 422
Query: 424 TIGHLITKEEIMHGLK 439
+ LI KEE+M+ ++
Sbjct: 423 KVRQLIIKEEMMNSIQ 438
>CE02632 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 490
Score = 309 bits (791), Expect = 6e-84
Identities = 167/443 (37%), Positives = 277/443 (61%), Gaps = 14/443 (3%)
Query: 8 KAEKDYTEILDAEFPKLEILAKNDYSSALDQLLVLEKKTRQSSDLASSKRVLTKIVDVLV 67
K E+DY++ +D K +A+ D +A++ L +EK TR +D+ S+ RV+ + +
Sbjct: 38 KMEQDYSKQVDEALLKARDIAQKDAVAAVESLNNIEKLTRLGADMKSNTRVVQYMTKLCF 97
Query: 68 AADQWDLLNDQIMLLSKKHGQLKLSVQYMIQSVMKYLEDLKDLDTKIKTIETIRTVTENK 127
+WDLL + IM LSKK +K+++ M++ + ++ + D K+K IET+RTVT K
Sbjct: 98 EGQKWDLLMETIMTLSKKRLLIKMAIAKMVRDAVAMIDKMPTEDLKMKLIETLRTVTAGK 157
Query: 128 IFVEVERARVTRDLVHIRRSENKIDEATDLLCELQVETYGSMEMYEKIEFILEQMELSIL 187
I+VEVERAR+T +V E K+DEA +L ELQVETYGSMEM EK++++LEQM S++
Sbjct: 158 IYVEVERARLTSMVVKKLEREGKLDEAATMLLELQVETYGSMEMREKVQYLLEQMRYSLV 217
Query: 188 KGDYSQATVLSRKILKKTFK---NEKYAALKLEYYNLLVKIGLHKKDYLEVAQYYQEIYN 244
+ D+ +AT++S+KI K F ++ LKL+YY+ +++IGLH +YL+V ++++EIY
Sbjct: 218 RNDFVRATIISKKINIKFFNKSDEDEVQNLKLKYYDSMIRIGLHDGNYLDVCRHHREIYE 277
Query: 245 SDSVKADEIQWKAALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVKLFTTA 304
+ +KAD + + L + + +L+P+ N Q DL++++ + L+ +P + ++ LF
Sbjct: 278 TKKIKADSAKATSHLRSAIVYCLLAPHTNEQWDLLNRIAIQRELETVPDYKIILDLFINQ 337
Query: 305 ELMRWP-IVQDTYKEILNQ------DGVAFGSN---ESHWEDLHKRIIEHNLRVISKYYT 354
EL+ + + Y+++L + D F + E W DLH R+ EHN+R+I+KYYT
Sbjct: 338 ELISFKGTIVAKYEKLLRRGTTSSPDTGIFDKSTEGEKRWSDLHLRVGEHNMRMIAKYYT 397
Query: 355 KITLPRLKELLDLDEAKTESFISDLVNQG-IIYAKINRPEKIVNFGKPNNSSDLLNEWSA 413
+IT RL ELLD + ESF+ +L+ G I AK++RP +IVN + + L+ W++
Sbjct: 398 QITFERLAELLDFPVDEMESFVCNLIVTGQITGAKLHRPSRIVNLRLKKANVEQLDVWAS 457
Query: 414 NVDQLLDHIETIGHLITKEEIMH 436
NV +L D + + HLI KE+++H
Sbjct: 458 NVHKLTDTLNKVSHLILKEQMVH 480
>At5g09900 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 442
Score = 297 bits (760), Expect = 2e-80
Identities = 161/428 (37%), Positives = 260/428 (60%), Gaps = 25/428 (5%)
Query: 34 SALDQLLVLEKKTRQSSDLASSKRVLTKIVDVLVAADQWDLLNDQIMLLSKKHGQLKLSV 93
+ +D+LL EK+ R + ++A +++ T+I+ + A W LLN+QI+ LSKK GQLK +V
Sbjct: 9 ATIDRLLNEEKQMRLAENVAGTRKAATEILQLCFDAKDWKLLNEQILNLSKKRGQLKQAV 68
Query: 94 QYMIQSVMKYLEDLKDLDTKIKTIETIRTVTENKIFVEVERARVTRDLVHIRRSENKIDE 153
Q M+Q M+Y++ D++T+I+ I+T+ V+ KI+VE+ERAR+T+ L I+ + +I E
Sbjct: 69 QSMVQQAMQYIDQTPDIETRIELIKTLNNVSAGKIYVEIERARLTKKLAKIKEEQGQIAE 128
Query: 154 ATDLLCELQVETYGSMEMYEKIEFILEQMELSILKGDYSQATVLSRKILKKTF----KNE 209
A DL+ E+ VET+G+M EKI FILEQ+ L + + D+ +A +LSRKI + F K +
Sbjct: 129 AADLMQEVAVETFGAMAKTEKIAFILEQVRLCLDRQDFVRAQILSRKINPRVFDADTKKD 188
Query: 210 K-------------------YAALKLEYYNLLVKIGLHKKDYLEVAQYYQEIYNSDSVKA 250
K LK YY L+++ H +Y+E+ + Y+ IY+ SVK
Sbjct: 189 KKKPKEGDNMVEEAPADIPTLLELKRIYYELMIRYYSHNNEYIEICRSYKAIYDIPSVKE 248
Query: 251 DEIQWKAALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVKLFTTAELMRWP 310
QW L ++ +FL+L+P+D +Q+ L++ D NL ++P + L+K T E+++W
Sbjct: 249 TPEQWIPVLRKICWFLVLAPHDPMQSSLLNATLEDKNLSEIPDFKMLLKQVVTMEVIQWT 308
Query: 311 IVQDTYKEILNQDGVAFGSN--ESHWEDLHKRIIEHNLRVISKYYTKITLPRLKELLDLD 368
+ + YK+ ++ G + + EDL RIIEHN+ V+SKYY +ITL RL ELL L
Sbjct: 309 SLWNKYKDEFEKEKSMIGGSLGDKAGEDLKLRIIEHNILVVSKYYARITLKRLAELLCLS 368
Query: 369 EAKTESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVDQLLDHIETIGHL 428
+ E +S++V + AKI+RP IV F +S+++LN W+ N+++LLD +E H
Sbjct: 369 MEEAEKHLSEMVVSKALIAKIDRPSGIVCFQIAKDSNEILNSWAGNLEKLLDLVEKSCHQ 428
Query: 429 ITKEEIMH 436
I KE ++H
Sbjct: 429 IHKETMVH 436
>At5g64760 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 529
Score = 291 bits (746), Expect = 1e-78
Identities = 163/439 (37%), Positives = 262/439 (59%), Gaps = 25/439 (5%)
Query: 23 KLEILAKNDYSSALDQLLVLEKKTRQSSDLASSKRVLTKIVDVLVAADQWDLLNDQIMLL 82
+L + S++D+LL EK+ R + ++A +++ T+I+ + A W LLN+QI+ L
Sbjct: 85 RLAMEESRQLESSIDRLLNEEKQMRLAENVAGTRKAATEILKLCFEAKDWKLLNEQILNL 144
Query: 83 SKKHGQLKLSVQYMIQSVMKYLEDLKDLDTKIKTIETIRTVTENKIFVEVERARVTRDLV 142
SKK GQLK +VQ M+Q M+Y++ D++T+I+ I+T+ V KI+VE+ERAR+T+ L
Sbjct: 145 SKKRGQLKQAVQSMVQQAMQYIDQTLDIETRIELIKTLNNVAAGKIYVEIERARLTKMLA 204
Query: 143 HIRRSENKIDEATDLLCELQVETYGSMEMYEKIEFILEQMELSILKGDYSQATVLSRKIL 202
I+ + I EA DL+ E+ VET+G+M EKI FILEQ+ L + + D+ +A +LSRKI
Sbjct: 205 KIKEEQGLIAEAADLMQEVAVETFGAMAKTEKIAFILEQVRLCLDQKDFVRAQILSRKIN 264
Query: 203 KKTF-----KNEK------------------YAALKLEYYNLLVKIGLHKKDYLEVAQYY 239
+ F K +K LK YY L+++ H +Y+E+ + Y
Sbjct: 265 PRVFDADTTKEKKKPKEGENMVEEAPADIPTLLVLKRIYYELMIRYYSHNNEYIEICRSY 324
Query: 240 QEIYNSDSVKADEIQWKAALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVK 299
+ IY+ SVK + QW L ++ +FL L+P+D +Q+ L++ D L ++P + L+K
Sbjct: 325 KAIYDIPSVKENPEQWIPVLRKICWFLALAPHDPMQSSLLNATLEDKKLSEIPDFKMLLK 384
Query: 300 LFTTAELMRWPIVQDTYK-EILNQDGVAFGS-NESHWEDLHKRIIEHNLRVISKYYTKIT 357
T E+++W + + YK E N+ + GS + EDL RIIEHN+ V+SKYY++IT
Sbjct: 385 QIVTMEVIQWTSLWNKYKDEFENEKNMIGGSLGDKAGEDLKLRIIEHNILVVSKYYSRIT 444
Query: 358 LPRLKELLDLDEAKTESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVDQ 417
RL ELL L + E +S++V + AKI+RP I+ F +S+++LN W+ N+++
Sbjct: 445 FKRLAELLCLTTEEAEKHLSEMVVSKALIAKIDRPSGIICFQIVKDSNEILNSWATNLEK 504
Query: 418 LLDHIETIGHLITKEEIMH 436
LLD +E H I KE ++H
Sbjct: 505 LLDLVEKSCHQIHKETMVH 523
>7296672 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 502
Score = 264 bits (674), Expect = 2e-70
Identities = 155/486 (31%), Positives = 266/486 (53%), Gaps = 57/486 (11%)
Query: 8 KAEKDYTEILDAEFPKLEILAKND---YSSALDQLLVLEKKTRQSSDLASSKRVLTKIVD 64
K E DY + + P + LAK + + A++ +L LEK+TR +D+ S RVL I
Sbjct: 13 KMEVDYEPACNEKIPLAKELAKKNPDAFHEAIEMMLQLEKQTRLGADMVSCSRVLVAICQ 72
Query: 65 VLVAADQWDLLNDQIMLLSKKHGQLKLSVQYMIQSVMKYLEDLKDLDTKIKTIETIRTVT 124
+ A W+ LN+ + LL ++ QLK +V MIQ + Y++ D +TK+K I+T+R+VT
Sbjct: 73 ICFDASNWNALNEYVSLLVRRRSQLKQAVVKMIQECVTYVDKTPDKETKLKLIDTLRSVT 132
Query: 125 ENKIFVEVERARVTRDLVHIRRSENKIDEATDLLCELQVETYGSMEMYEKIEFILEQMEL 184
E KI+VE+ERAR+T+ L I+ ++ + A ++ ELQVETYGSM+ EK+E ILEQM L
Sbjct: 133 EGKIYVEIERARLTKILADIKEADGDVAGAATVMEELQVETYGSMDKREKVELILEQMRL 192
Query: 185 SILKGDYSQATVLSRKILKKTFKNEKYAALKLEYYNLLVKIGLHKKDYLEVAQYYQEI-- 242
+LK DY ++++KI K F + LKL++Y L++++ +L +++YQ I
Sbjct: 193 CLLKEDYVSTQIIAKKISIKFFDDPAQHDLKLKFYYLMIQLN-RDTSFLNTSRHYQAIAE 251
Query: 243 ------------------------------YNSDSVKADEIQWKA--------------- 257
D K E+ +A
Sbjct: 252 PPRKKTGLTPVDSAASTDEQKKKDDDKKKKEEDDKDKKPEVATEAEVEIELTEEQKKELT 311
Query: 258 -ALSRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVKLFTTAELMRWPIVQDTY 316
L V + +L+P+DN Q+D++ + + L+++P+ + +++LF + EL+ + +
Sbjct: 312 EKLVCAVLYCVLAPFDNEQSDMMAHLSKNKKLEEVPAYKEILRLFMSKELINFDTFNADF 371
Query: 317 KEILNQDGVAFGSNESHWE----DLHKRIIEHNLRVISKYYTKITLPRLKELLDLDEAKT 372
+L ++ + F + H + +L R+IEHN+R+I+ YY+++ L R+ ELL+L ++
Sbjct: 372 GLVLAENEM-FKDSTKHGKKCITELKDRLIEHNIRIIAMYYSRLHLARMSELLNLPTSRC 430
Query: 373 ESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVDQLLDHIETIGHLITKE 432
E ++S L N I KI+RP I+ F + ++SD+LN W+ +V+QL+ + HLI KE
Sbjct: 431 EEYLSKLANTDTIRVKIDRPAGIIYFTQKKSASDILNNWATDVNQLMSLVNKTCHLINKE 490
Query: 433 EIMHGL 438
E ++ +
Sbjct: 491 ECVYSV 496
>ECU05g1080 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 387
Score = 121 bits (303), Expect = 2e-27
Identities = 95/405 (23%), Positives = 193/405 (47%), Gaps = 21/405 (5%)
Query: 36 LDQLLVLEKKTRQSSDLASSKRVLTKIVDVLVAADQWDLLNDQIMLLSKKHGQLKLSVQY 95
+++LL E+K R +D ++ +++ + + ++ L + +L+ K GQ + ++++
Sbjct: 1 MEELLERERKARVKNDYEMLLKIFEELMSLCKSDEELGCL---VRVLTIKRGQNRAAIKW 57
Query: 96 MIQSVMKYLEDLKDLDTKIKTIETIRTVTENKIFVEVERARVTRDLVHIRRSENKIDEAT 155
MI + + + + I ++ V E +IF+E ER +T +L + A
Sbjct: 58 MIWQLFERKKGEEGFVEFFSQI--LKDVIEGRIFLEDERIYITEELKRRYELCGDVRSAL 115
Query: 156 DLLCELQVETYGSMEMYEKIEFILEQMELSILKGDYSQATVLSRKILKKTFKNEKYAALK 215
D++ + VET+ ++ + + LEQ+ L + D+ +A + +KI KK F+ A K
Sbjct: 116 DVVINVPVETFTMVKESVVVNYQLEQLRLCVSNLDWIRADITMKKIRKKYFEENDAAEEK 175
Query: 216 LEYYNLLVKIGLHKKDYLEVAQYYQEIYNSDSVKADEIQWKAALSRVVYFLILSPYD-NL 274
+++Y L+V++ L ++ Y + ++Y+S S + LS +F IL+ + +
Sbjct: 176 IKFYELVVQLHLGQRKYFNAS----DVYHSLSTLGENATGYVVLSS--FFCILTTCETEM 229
Query: 275 QNDLIHKVQLDNNLKKLPSQESLVKLFTTAELMRWPIVQDTYKEILNQDGVAFGSNESHW 334
+N + K + L + + + +V+ L R + + T EIL A + +
Sbjct: 230 ENIVCKKSGMLKMLSEDKNNDEVVRSVVNRFLSRVVVDRSTADEILQAFSFAVDVS-VYL 288
Query: 335 EDLHKRIIEHNLRVISKYYTKITLPRLKELLDLDEAKTESFISDLVNQGIIYAKINRPEK 394
+DL I EHN R+I ++Y+ I++ + ++ IS +VN G KIN+
Sbjct: 289 DDLLSAIDEHNFRIIERFYSSISVQEISMVMQSPAEDIIKKISFMVNNGFAQCKINQKTG 348
Query: 395 IVNFGKPNNSSDLLNEWSANVDQLLDHIETIGHLITKEEIMHGLK 439
I+ F K +W+ NV+ ++ + HLI KE + +K
Sbjct: 349 IIEFEK--------RKWNDNVEDVMGKLIKCNHLIHKERLRLSIK 385
>Hs18554904 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 113
Score = 88.2 bits (217), Expect = 2e-17
Identities = 45/112 (40%), Positives = 73/112 (65%), Gaps = 9/112 (8%)
Query: 305 ELMRWPIVQDTYKEILNQDGV------AFGSNES---HWEDLHKRIIEHNLRVISKYYTK 355
ELMRW + + Y L + V AFGS E W+DL+ R++EHN+R+++KYYT+
Sbjct: 2 ELMRWSTLVEDYGMELRKGSVGSPATDAFGSTEEGEKRWKDLNNRVVEHNIRIMAKYYTR 61
Query: 356 ITLPRLKELLDLDEAKTESFISDLVNQGIIYAKINRPEKIVNFGKPNNSSDL 407
+T+ R+ +LLDL ++E+F+S+LV I+AK++R I NF +P + ++L
Sbjct: 62 MTMKRMVQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGINNFQRPKDPNNL 113
>7304120 [OT] KOG1497 COP9 signalosome subunit CSN4
Length = 407
Score = 77.8 bits (190), Expect = 3e-14
Identities = 92/403 (22%), Positives = 169/403 (41%), Gaps = 25/403 (6%)
Query: 38 QLLVLEKKTRQSSDLASSKRVLTKIVDVLVAADQWDLLNDQIMLLSKKHGQLKLSVQYMI 97
QL+ L T D A R L K V + D L + + +H L +S Q ++
Sbjct: 15 QLMGLINFTGTHKDQADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQ-IL 73
Query: 98 QSVMKYLEDLKDLDTKIKTIETIRTVTENKIFVEVERARVTRDLVHIRRSENKIDEATDL 157
V L L D +K+ + T+ V I E + A + L +I + +A +
Sbjct: 74 NDVGSELSKLPDDLSKMLSHFTLEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATV 133
Query: 158 LCELQVETYGSMEMYE-KIEFILEQMELSILKGDYSQATV-LSRKILKKTFKNEKYAALK 215
L + +ET E K+ L+ L + D QA + ++R L + N + L+
Sbjct: 134 LVGIPLETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSE--ELQ 191
Query: 216 LEYYNLLVKIGLHKKDYLEVAQYYQEIYNSDSVKADEIQWKAALSRVVYFLILSPYDNLQ 275
+ Y ++ +++ ++E AQ Y E+ V D+ + AL + + +L+ +
Sbjct: 192 VLYKVCYARVLDYRRKFIEAAQRYNELSYRKIV--DQGERMTALKKALICTVLASAGQQR 249
Query: 276 NDLIHKVQLDNNLKKLPSQESLVKLFTT-----AELMRWPIVQDTYKEILNQDGVAFGSN 330
+ ++ + D + LP+ L K++ +EL + + +++ DG +
Sbjct: 250 SRMLATLFKDERCQHLPAYGILEKMYLERIIRRSELQEFEALLQDHQKAATSDGSSI--- 306
Query: 331 ESHWEDLHKRIIEHNLRVISKYYTKITLPRLKELLDLDEAKTESFISDLVNQGIIYAKIN 390
L + + EHNL SK Y IT L LLD+ K E S ++ +G + I+
Sbjct: 307 ------LDRAVFEHNLLSASKLYNNITFEELGALLDIPAVKAEKIASQMITEGRMNGHID 360
Query: 391 RPEKIVNFGKPNNSSDLLNEWSANVDQLLDHIETIGHLITKEE 433
+ IV+F + +LL +W + L + +I I+ E
Sbjct: 361 QISAIVHF----ENRELLPQWDRQIQSLCYQVNSIIEKISVAE 399
>Hs7705845 [OT] KOG1497 COP9 signalosome subunit CSN4
Length = 405
Score = 71.2 bits (173), Expect = 3e-12
Identities = 85/397 (21%), Positives = 163/397 (40%), Gaps = 31/397 (7%)
Query: 39 LLVLEKKTRQSSDLASSKRVLTKIVDVLVAADQWDLLNDQIMLLSKKHGQLKLSVQYMIQ 98
L L + DLA R + + L A+Q + L + + ++ L +S Q ++
Sbjct: 8 LAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQ-LLT 66
Query: 99 SVMKYLEDLKDLDTKIKTIETIRTVTENKIFVEVERARVTRDLVHIRRSENKIDEATDLL 158
+L +L D K T+ + I E + A + + L I E A +L
Sbjct: 67 DFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVL 126
Query: 159 CELQVETYGSMEMYE---KIEFILEQMELSILKGDYSQATVLSRK--ILKKTFKNEKYAA 213
+ +ET + Y K+E L+ L + D QA + +L+ NE+
Sbjct: 127 VGIPLET--GQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQ--- 181
Query: 214 LKLEYYNLLVKIGLHKKDYLEVAQYYQEIYNSDSVKADEIQWKAALSRVVYFLILSPYDN 273
L++ Y ++ +++ ++E AQ Y E+ S E + AL ++ IL+
Sbjct: 182 LQIHYKVCYARVLDYRRKFIEAAQRYNEL--SYKTIVHESERLEALKHALHCTILASAGQ 239
Query: 274 LQNDLIHKVQLDNNLKKLPSQESLVKLFTTA-----ELMRWPIVQDTYKEILNQDGVAFG 328
++ ++ + D ++L + L K++ +L + + +++ DG +
Sbjct: 240 QRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSI- 298
Query: 329 SNESHWEDLHKRIIEHNLRVISKYYTKITLPRLKELLDLDEAKTESFISDLVNQGIIYAK 388
L + +IEHNL SK Y IT L LL++ AK E S ++ +G +
Sbjct: 299 --------LDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGF 350
Query: 389 INRPEKIVNFGKPNNSSDLLNEWSANVDQLLDHIETI 425
I++ + IV+F + + L W + L + +
Sbjct: 351 IDQIDGIVHF----ETREALPTWDKQIQSLCFQVNNL 383
>Hs22043519 [O] KOG1498 26S proteasome regulatory complex subunit RPN5/PSMD12
Length = 209
Score = 69.7 bits (169), Expect = 8e-12
Identities = 38/92 (41%), Positives = 55/92 (59%), Gaps = 1/92 (1%)
Query: 8 KAEKDYTEILDAEFPKLEILAKND-YSSALDQLLVLEKKTRQSSDLASSKRVLTKIVDVL 66
K E DY +D P+ E LAK ++ LL LEK+TR +SD+ S+ ++L +V +
Sbjct: 118 KMEVDYNATVDQCLPECEKLAKEGRLQEVMETLLSLEKQTRTASDMGSTSQILVAVVKMC 177
Query: 67 VAADQWDLLNDQIMLLSKKHGQLKLSVQYMIQ 98
A +WDLLN+ I LLSK+ QL +V M+Q
Sbjct: 178 YEAKEWDLLNENITLLSKRRSQLIQAVAKMVQ 209
>At5g42970 [OT] KOG1497 COP9 signalosome subunit CSN4
Length = 397
Score = 62.0 bits (149), Expect = 2e-09
Identities = 89/406 (21%), Positives = 168/406 (40%), Gaps = 39/406 (9%)
Query: 28 AKNDYSSALDQLLVLEKKTRQSSDLASSKRVLTKIVDVLVAADQWDLLNDQIMLLSKKHG 87
A D ++Q ++ S+DL ++R + I L+D + L+ +
Sbjct: 10 AIGDQRQKIEQYKLILSSVLSSNDLLQAQRFIDHI------------LSDDVPLVVSRQ- 56
Query: 88 QLKLSVQYMIQSVMKYLEDLKDLDTKIKTIETIRTVTENKIFVEVERARVTRD-LVHIRR 146
++QS + L L+ +T+ + + T + ++ E+A V R+ L +
Sbjct: 57 --------LLQSFAQELGRLEP-ETQKEIAQFTLTQIQPRVVSFEEQALVIREKLAGLYE 107
Query: 147 SENKIDEATDLLCELQVETYGSMEMYEKIEFILEQMELSILKGDYSQATVLSRKILKKTF 206
SE + +A +L + +++ M + + + ++++ L + A I K +F
Sbjct: 108 SEQEWSKAAQMLSGIDLDS--GMRAVDDNFKLSKCIQIARLYLEDDDAVNAEAFINKASF 165
Query: 207 --KNEKYAALKLEYYNLLVKIGLHKKDYLEVAQYYQEIYNSDS-----VKADEIQWKAAL 259
N + L L+Y +I K+ +LE A Y I + + DE + AL
Sbjct: 166 LVSNSQNEVLNLQYKVCYARILDMKRKFLEAALRYYGISQIEQRQIGDEEIDENALEQAL 225
Query: 260 SRVVYFLILSPYDNLQNDLIHKVQLDNNLKKLPSQESLVKLFTTAELMRWPIVQDTYKEI 319
S V IL+ ++ ++ + D KL L K++ L R I D + E
Sbjct: 226 SAAVTCTILAGAGPQRSRVLATLYKDERCSKLKIYPILQKVYLERILRRPEI--DAFSEE 283
Query: 320 LNQDGVAFGSNESHWEDLHKRIIEHNLRVISKYYTKITLPRLKELLDLDEAKTESFISDL 379
L A ++S L + +IEHNL SK YT I L LL +D K E +++
Sbjct: 284 LRPHQKASLPDKS--TVLDRAMIEHNLLSASKLYTNIRFDELGTLLAIDPRKAEKIAANM 341
Query: 380 VNQGIIYAKINRPEKIVNFGKPNNSSDLLNEWSANVDQLLDHIETI 425
+ Q + I++ E +++F + + L +W + L + I
Sbjct: 342 IGQDRMRGSIDQEEAVIHF---EDDVEELQQWDQQISGLCQALNDI 384
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,083,266
Number of Sequences: 60738
Number of extensions: 995550
Number of successful extensions: 3715
Number of sequences better than 1.0e-05: 14
Number of HSP's better than 0.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3684
Number of HSP's gapped (non-prelim): 15
length of query: 441
length of database: 30,389,216
effective HSP length: 109
effective length of query: 332
effective length of database: 23,768,774
effective search space: 7891232968
effective search space used: 7891232968
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)