ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4107 check: MH T KOG0581 Signal transduction mechanisms Mitogen-activated protein kinase kinase (MAP2K)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4107 1452695 1451184 -504
(504 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 460 e-129
Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 228 2e-59
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 222 1e-57
Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (... 215 1e-55
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 199 1e-50
Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (... 197 4e-50
Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 189 6e-48
Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (... 189 6e-48
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 187 2e-47
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 187 2e-47
CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 187 4e-47
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 186 5e-47
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 183 6e-46
YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 177 4e-44
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 174 4e-43
Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (... 171 3e-42
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 170 4e-42
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 162 1e-39
Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) ki... 158 2e-38
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 156 6e-38
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 155 2e-37
7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 154 3e-37
CE07399 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 151 3e-36
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 147 3e-35
Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 147 4e-35
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 146 8e-35
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 144 3e-34
HsM4506099 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 144 4e-34
Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 144 4e-34
CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 144 4e-34
At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 144 4e-34
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 143 5e-34
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 143 7e-34
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 142 9e-34
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 142 9e-34
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 142 9e-34
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 142 9e-34
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 142 9e-34
Hs21618351 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 142 1e-33
Hs21618349 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 142 1e-33
Hs21618347 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 142 1e-33
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 141 2e-33
CE16527 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 139 1e-32
7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 139 1e-32
At3g15220 [T] KOG0201 Serine/threonine protein kinase 138 2e-32
7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 137 3e-32
CE29622 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 135 1e-31
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 131 2e-30
At1g53165 [T] KOG0201 Serine/threonine protein kinase 131 2e-30
Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 130 5e-30
7300224 [T] KOG0201 Serine/threonine protein kinase 129 1e-29
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 129 1e-29
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 129 1e-29
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 129 1e-29
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 128 2e-29
Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 128 2e-29
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 128 2e-29
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 128 2e-29
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 128 2e-29
At3g06230 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 127 3e-29
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 127 4e-29
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 127 4e-29
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 127 4e-29
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 127 4e-29
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 127 5e-29
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 127 5e-29
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 126 7e-29
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 126 7e-29
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 126 7e-29
At1g32320 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 125 1e-28
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 123 6e-28
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 123 7e-28
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 122 1e-27
CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 122 2e-27
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 121 2e-27
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 121 2e-27
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 121 2e-27
CE07510 [T] KOG0201 Serine/threonine protein kinase 120 5e-27
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 120 6e-27
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 120 6e-27
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 119 1e-26
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 119 1e-26
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 119 1e-26
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 118 2e-26
CE28674 [T] KOG0201 Serine/threonine protein kinase 118 2e-26
CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 118 2e-26
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 118 2e-26
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 117 4e-26
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 117 5e-26
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 116 7e-26
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 114 3e-25
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 114 3e-25
Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 112 1e-24
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 112 1e-24
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 112 1e-24
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 112 2e-24
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 111 2e-24
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 110 5e-24
7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 110 5e-24
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 110 6e-24
At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase 109 8e-24
Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase k... 109 1e-23
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 109 1e-23
CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase 108 1e-23
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 108 2e-23
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 108 2e-23
CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 108 2e-23
CE01405 [T] KOG0577 Serine/threonine protein kinase 108 2e-23
YDR523c [T] KOG0201 Serine/threonine protein kinase 107 4e-23
Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase k... 107 5e-23
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 106 7e-23
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 105 1e-22
YHR102w [T] KOG0201 Serine/threonine protein kinase 105 2e-22
CE27177 [T] KOG4279 Serine/threonine protein kinase 105 2e-22
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 105 2e-22
At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase 105 2e-22
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 104 3e-22
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 104 4e-22
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 103 6e-22
Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE 103 8e-22
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 103 8e-22
7293601 [T] KOG0577 Serine/threonine protein kinase 102 1e-21
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 102 1e-21
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 102 2e-21
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 102 2e-21
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 101 2e-21
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 101 2e-21
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 101 2e-21
Hs4505649 [R] KOG0594 Protein kinase PCTAIRE and related kinases 101 2e-21
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 101 2e-21
Hs5453860 [R] KOG0594 Protein kinase PCTAIRE and related kinases 100 4e-21
Hs15011928 [R] KOG0594 Protein kinase PCTAIRE and related kinases 100 4e-21
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 100 5e-21
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 100 5e-21
CE04493 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 100 7e-21
YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases 99 1e-20
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 99 1e-20
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 99 2e-20
At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase 99 2e-20
At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 2e-20
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 99 2e-20
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 98 3e-20
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 98 3e-20
At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase 98 3e-20
At1g05100 [T] KOG0198 MEKK and related serine/threonine protein ... 98 3e-20
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 97 4e-20
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 97 6e-20
7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 97 6e-20
At4g32830 [D] KOG0580 Serine/threonine protein kinase 96 1e-19
Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 96 1e-19
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 96 2e-19
At2g25880 [D] KOG0580 Serine/threonine protein kinase 95 2e-19
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 95 2e-19
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 95 3e-19
CE29073 [R] KOG0594 Protein kinase PCTAIRE and related kinases 95 3e-19
CE06779 [R] KOG0594 Protein kinase PCTAIRE and related kinases 95 3e-19
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 94 4e-19
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 94 4e-19
Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 94 4e-19
Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE 94 5e-19
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 94 6e-19
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 93 8e-19
Hs22065797 [T] KOG0577 Serine/threonine protein kinase 93 1e-18
Hs16160923 [R] KOG0594 Protein kinase PCTAIRE and related kinases 93 1e-18
YGR040w [T] KOG0660 Mitogen-activated protein kinase 92 1e-18
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 92 1e-18
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 92 1e-18
7299536 [D] KOG0580 Serine/threonine protein kinase 92 1e-18
At5g37790 [T] KOG1187 Serine/threonine protein kinase 92 2e-18
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 92 2e-18
7301213 [R] KOG0589 Serine/threonine protein kinase 92 2e-18
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 92 2e-18
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 92 2e-18
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 92 2e-18
At1g66460 [T] KOG1187 Serine/threonine protein kinase 92 2e-18
At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase 91 3e-18
Hs17461944 [R] KOG0593 Predicted protein kinase KKIAMRE 91 4e-18
Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase 91 4e-18
At1g29230 [T] KOG0583 Serine/threonine protein kinase 91 4e-18
CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 91 5e-18
7300559 [T] KOG4279 Serine/threonine protein kinase 91 5e-18
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 91 5e-18
YPL209c [D] KOG0580 Serine/threonine protein kinase 90 7e-18
YCL024w [T] KOG0583 Serine/threonine protein kinase 90 7e-18
SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protei... 90 7e-18
CE27573 [T] KOG0198 MEKK and related serine/threonine protein ki... 90 9e-18
CE07737 [T] KOG0198 MEKK and related serine/threonine protein ki... 90 9e-18
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 90 9e-18
7297009 [R] KOG0593 Predicted protein kinase KKIAMRE 89 1e-17
At2g32510 [T] KOG0198 MEKK and related serine/threonine protein ... 89 2e-17
CE27902 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 89 2e-17
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 88 3e-17
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 88 3e-17
Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 88 3e-17
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 88 3e-17
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 88 3e-17
YLR362w [T] KOG0198 MEKK and related serine/threonine protein ki... 88 3e-17
YBL016w [T] KOG0660 Mitogen-activated protein kinase 88 3e-17
CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 88 3e-17
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 88 3e-17
At1g78530 [T] KOG1187 Serine/threonine protein kinase 88 3e-17
At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase 88 3e-17
7299437 [R] KOG0586 Serine/threonine protein kinase 88 3e-17
Hs18602554 [T] KOG0578 p21-activated serine/threonine protein ki... 87 4e-17
CE21025 [D] KOG0580 Serine/threonine protein kinase 87 6e-17
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 87 6e-17
YKL101w [D] KOG0588 Serine/threonine protein kinase 87 8e-17
Hs4758702 [T] KOG4279 Serine/threonine protein kinase 87 8e-17
Hs4507361 [T] KOG0192 Tyrosine kinase specific for activated (GT... 87 8e-17
Hs21735566 [T] KOG0192 Tyrosine kinase specific for activated (G... 87 8e-17
Hs21735564 [T] KOG0192 Tyrosine kinase specific for activated (G... 87 8e-17
Hs21735562 [T] KOG0192 Tyrosine kinase specific for activated (G... 87 8e-17
CE28479 [T] KOG0583 Serine/threonine protein kinase 87 8e-17
CE18699 [T] KOG0694 Serine/threonine protein kinase 87 8e-17
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 87 8e-17
At1g70740 [T] KOG1187 Serine/threonine protein kinase 87 8e-17
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 87 8e-17
HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains ... 86 1e-16
Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase 86 1e-16
Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains ... 86 1e-16
CE27574 [T] KOG0665 Jun-N-terminal kinase (JNK) 86 1e-16
CE24761 [D] KOG0580 Serine/threonine protein kinase 86 1e-16
CE15235 [R] KOG0589 Serine/threonine protein kinase 86 1e-16
At1g67580 [R] KOG0663 Protein kinase PITSLRE and related kinases 86 1e-16
7299438 [R] KOG0586 Serine/threonine protein kinase 86 1e-16
SPBC11B10.09 [R] KOG0594 Protein kinase PCTAIRE and related kinases 86 1e-16
At3g45240 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase k... 86 1e-16
7302464 [R] KOG0586 Serine/threonine protein kinase 86 1e-16
Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE 86 2e-16
Hs21361133 [R] KOG0586 Serine/threonine protein kinase 86 2e-16
At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GT... 86 2e-16
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 86 2e-16
At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 86 2e-16
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 85 2e-16
Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases 85 2e-16
CE28218 [D] KOG0588 Serine/threonine protein kinase 85 2e-16
CE24994 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 85 2e-16
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 85 2e-16
CE03080 [R] KOG0584 Serine/threonine protein kinase 85 2e-16
At2g34180 [T] KOG0583 Serine/threonine protein kinase 85 2e-16
SPAC23H4.02 [T] KOG0583 Serine/threonine protein kinase 85 3e-16
CE24971 [T] KOG0660 Mitogen-activated protein kinase 85 3e-16
CE01583 [T] KOG0660 Mitogen-activated protein kinase 85 3e-16
At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase 85 3e-16
7297776 [D] KOG0580 Serine/threonine protein kinase 85 3e-16
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 85 3e-16
Hs21040235 [R] KOG0594 Protein kinase PCTAIRE and related kinases 84 4e-16
At5g42120 [T] KOG1187 Serine/threonine protein kinase 84 4e-16
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 84 4e-16
YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 84 5e-16
SPAC24B11.06c [T] KOG0660 Mitogen-activated protein kinase 84 5e-16
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 84 5e-16
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 84 5e-16
Hs14768528 [T] KOG1187 Serine/threonine protein kinase 84 5e-16
CE29453 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 84 5e-16
CE23001 [R] KOG0589 Serine/threonine protein kinase 84 5e-16
At1g16670 [T] KOG1187 Serine/threonine protein kinase 84 5e-16
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 84 6e-16
Hs9055206 [T] KOG1989 ARK protein kinase family 84 6e-16
Hs7706601 [T] KOG0192 Tyrosine kinase specific for activated (GT... 84 6e-16
Hs6912584 [R] KOG0594 Protein kinase PCTAIRE and related kinases 84 6e-16
Hs19526767 [T] KOG0192 Tyrosine kinase specific for activated (G... 84 6e-16
At5g25110 [T] KOG0583 Serine/threonine protein kinase 84 6e-16
At4g18710 [G] KOG0658 Glycogen synthase kinase-3 84 6e-16
Hs17452757 [UT] KOG0662 Cyclin-dependent kinase CDK5 83 8e-16
CE29612 [R] KOG0594 Protein kinase PCTAIRE and related kinases 83 8e-16
CE28918 [R] KOG0594 Protein kinase PCTAIRE and related kinases 83 8e-16
CE18608 [R] KOG0594 Protein kinase PCTAIRE and related kinases 83 8e-16
CE18009 [R] KOG0594 Protein kinase PCTAIRE and related kinases 83 8e-16
CE06686 [T] KOG0660 Mitogen-activated protein kinase 83 8e-16
At5g60550 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase k... 83 8e-16
At5g35410 [T] KOG0583 Serine/threonine protein kinase 83 8e-16
At1g60940 [T] KOG0583 Serine/threonine protein kinase 83 8e-16
Hs14150045 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 83 1e-15
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 83 1e-15
At3g45640 [T] KOG0660 Mitogen-activated protein kinase 83 1e-15
At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 83 1e-15
7302908 [R] KOG0594 Protein kinase PCTAIRE and related kinases 83 1e-15
YBL105c [T] KOG0694 Serine/threonine protein kinase 82 1e-15
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 82 1e-15
Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases 82 1e-15
CE27768 [R] KOG0586 Serine/threonine protein kinase 82 1e-15
CE23838 [R] KOG0586 Serine/threonine protein kinase 82 1e-15
At5g08590 [T] KOG0583 Serine/threonine protein kinase 82 1e-15
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 82 1e-15
7303915 [T] KOG0694 Serine/threonine protein kinase 82 1e-15
7303914 [T] KOG0694 Serine/threonine protein kinase 82 1e-15
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 82 1e-15
YBR160w [R] KOG0594 Protein kinase PCTAIRE and related kinases 82 2e-15
Hs20986521 [T] KOG0665 Jun-N-terminal kinase (JNK) 82 2e-15
Hs20986519 [T] KOG0665 Jun-N-terminal kinase (JNK) 82 2e-15
CE20636 [D] KOG0590 Checkpoint kinase and related serine/threoni... 82 2e-15
CE20258 [R] KOG0593 Predicted protein kinase KKIAMRE 82 2e-15
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 82 2e-15
At3g29160 [T] KOG0583 Serine/threonine protein kinase 82 2e-15
At2g30360 [T] KOG0583 Serine/threonine protein kinase 82 2e-15
7290147 [T] KOG0583 Serine/threonine protein kinase 82 2e-15
SPCC297.03 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 82 2e-15
SPBC8D2.01 [G] KOG0658 Glycogen synthase kinase-3 82 2e-15
Hs7705841 [T] KOG1187 Serine/threonine protein kinase 82 2e-15
Hs5453882 [G] KOG0599 Phosphorylase kinase gamma subunit 82 2e-15
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 82 2e-15
CE26076 [D] KOG0590 Checkpoint kinase and related serine/threoni... 82 2e-15
At3g56760 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 82 2e-15
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 82 2e-15
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 82 2e-15
7300650 [R] KOG0594 Protein kinase PCTAIRE and related kinases 82 2e-15
7290565 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 82 2e-15
Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains l... 81 3e-15
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 81 3e-15
CE21879 [D] KOG0590 Checkpoint kinase and related serine/threoni... 81 3e-15
At5g57630 [T] KOG0583 Serine/threonine protein kinase 81 3e-15
At2g45490 [D] KOG0580 Serine/threonine protein kinase 81 3e-15
At1g49160 [R] KOG0584 Serine/threonine protein kinase 81 3e-15
7303211 [T] KOG4717 Serine/threonine protein kinase 81 3e-15
7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 81 3e-15
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 81 3e-15
Hs4758194 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 81 4e-15
CE23605 [T] KOG0665 Jun-N-terminal kinase (JNK) 81 4e-15
At5g67080 [T] KOG0198 MEKK and related serine/threonine protein ... 81 4e-15
At5g63650 [T] KOG0583 Serine/threonine protein kinase 81 4e-15
At4g40010 [T] KOG0583 Serine/threonine protein kinase 81 4e-15
At4g34500 [T] KOG1187 Serine/threonine protein kinase 81 4e-15
At4g04700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 81 4e-15
At3g09010 [T] KOG1187 Serine/threonine protein kinase 81 4e-15
At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 81 4e-15
At2g31010 [T] KOG0192 Tyrosine kinase specific for activated (GT... 81 4e-15
YPL150w [T] KOG0583 Serine/threonine protein kinase 80 5e-15
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 80 5e-15
At2g25090 [T] KOG0583 Serine/threonine protein kinase 80 5e-15
7294217 [D] KOG0588 Serine/threonine protein kinase 80 5e-15
7293761 [T] KOG4721 Serine/threonine protein kinase contains leu... 80 5e-15
Hs12711660 [R] KOG0584 Serine/threonine protein kinase 80 7e-15
At5g58950 [T] KOG0192 Tyrosine kinase specific for activated (GT... 80 7e-15
At5g49470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 80 7e-15
At3g18750 [R] KOG0584 Serine/threonine protein kinase 80 7e-15
At2g43790 [T] KOG0660 Mitogen-activated protein kinase 80 7e-15
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 80 7e-15
YDR507c [D] KOG0588 Serine/threonine protein kinase 80 9e-15
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 80 9e-15
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 80 9e-15
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 80 9e-15
At4g31110 [T] KOG1187 Serine/threonine protein kinase 80 9e-15
YHR030c [T] KOG0660 Mitogen-activated protein kinase 79 1e-14
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 79 1e-14
Hs22057171 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 79 1e-14
ECU11g1500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 79 1e-14
CE02604 [T] KOG0695 Serine/threonine protein kinase 79 1e-14
At5g45810 [T] KOG0583 Serine/threonine protein kinase 79 1e-14
At5g35960 [T] KOG1187 Serine/threonine protein kinase 79 1e-14
At4g01330 [T] KOG1187 Serine/threonine protein kinase 79 1e-14
At1g57870 [G] KOG0658 Glycogen synthase kinase-3 79 1e-14
At1g29720 [T] KOG1187 Serine/threonine protein kinase 79 1e-14
YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 79 2e-14
Hs20986516 [T] KOG0660 Mitogen-activated protein kinase 79 2e-14
Hs20986514 [T] KOG0660 Mitogen-activated protein kinase 79 2e-14
Hs20986512 [T] KOG0660 Mitogen-activated protein kinase 79 2e-14
CE20167 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 79 2e-14
CE18454 [T] KOG4717 Serine/threonine protein kinase 79 2e-14
At4g18700 [T] KOG0583 Serine/threonine protein kinase 79 2e-14
At3g50310 [T] KOG0198 MEKK and related serine/threonine protein ... 79 2e-14
At2g17890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 79 2e-14
7297631 [T] KOG0665 Jun-N-terminal kinase (JNK) 79 2e-14
YLR113w [T] KOG0660 Mitogen-activated protein kinase 79 2e-14
Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 79 2e-14
Hs20986529 [T] KOG0660 Mitogen-activated protein kinase 79 2e-14
Hs14670383 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 79 2e-14
CE23524 [T] KOG1151 Tousled-like protein kinase 79 2e-14
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 79 2e-14
At5g39440 [T] KOG0583 Serine/threonine protein kinase 79 2e-14
At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GT... 79 2e-14
At2g42550 [T] KOG0198 MEKK and related serine/threonine protein ... 79 2e-14
At2g30980 [G] KOG0658 Glycogen synthase kinase-3 79 2e-14
At1g49270 [T] KOG1187 Serine/threonine protein kinase 79 2e-14
7304283 [Z] KOG0613 Projectin/twitchin and related proteins 79 2e-14
Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 79 2e-14
Hs5032091 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 78 3e-14
Hs4557439 [R] KOG0594 Protein kinase PCTAIRE and related kinases 78 3e-14
Hs20986531 [T] KOG0660 Mitogen-activated protein kinase 78 3e-14
Hs20562757 [T] KOG0660 Mitogen-activated protein kinase 78 3e-14
Hs19923134 [T] KOG4250 TANK binding protein kinase TBK1 78 3e-14
CE29478 [T] KOG0664 Nemo-like MAPK-related serine/threonine prot... 78 3e-14
CE29477 [T] KOG0664 Nemo-like MAPK-related serine/threonine prot... 78 3e-14
CE29476 [T] KOG0664 Nemo-like MAPK-related serine/threonine prot... 78 3e-14
CE21213 [UT] KOG0662 Cyclin-dependent kinase CDK5 78 3e-14
CE20716 [T] KOG0194 Protein tyrosine kinase 78 3e-14
CE20493 [TR] KOG0606 Microtubule-associated serine/threonine kin... 78 3e-14
CE19992 [T] KOG0194 Protein tyrosine kinase 78 3e-14
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 78 3e-14
At5g63370 [R] KOG0663 Protein kinase PITSLRE and related kinases 78 3e-14
At4g36070 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 78 3e-14
At4g33950 [T] KOG0583 Serine/threonine protein kinase 78 3e-14
At2g39110 [T] KOG1187 Serine/threonine protein kinase 78 3e-14
At2g35890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 78 3e-14
At1g10940 [T] KOG0583 Serine/threonine protein kinase 78 3e-14
7303051 [UT] KOG0662 Cyclin-dependent kinase CDK5 78 3e-14
7290249 [R] KOG0586 Serine/threonine protein kinase 78 3e-14
SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase 78 4e-14
Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 78 4e-14
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 78 4e-14
CE00747 [T] KOG0200 Fibroblast/platelet-derived growth factor re... 78 4e-14
At5g66210 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 78 4e-14
At5g15730 [T] KOG1187 Serine/threonine protein kinase 78 4e-14
At5g11850 [T] KOG0192 Tyrosine kinase specific for activated (GT... 78 4e-14
At2g30730 [T] KOG1187 Serine/threonine protein kinase 78 4e-14
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 78 4e-14
YHR205w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 77 5e-14
Hs4826675 [UT] KOG0662 Cyclin-dependent kinase CDK5 77 5e-14
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 77 5e-14
ECU08g1920 [R] KOG0594 Protein kinase PCTAIRE and related kinases 77 5e-14
At5g07070 [T] KOG0583 Serine/threonine protein kinase 77 5e-14
At4g14580 [T] KOG0583 Serine/threonine protein kinase 77 5e-14
At3g23000 [T] KOG0583 Serine/threonine protein kinase 77 5e-14
At3g06630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 5e-14
At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 77 5e-14
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 5e-14
At1g17910 [T] KOG1187 Serine/threonine protein kinase 77 5e-14
At1g10620 [T] KOG1187 Serine/threonine protein kinase 77 5e-14
7298766 [T] KOG0200 Fibroblast/platelet-derived growth factor re... 77 5e-14
7295585 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 77 5e-14
CE18058_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 77 5e-14
SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kina... 77 6e-14
SPAC22E12.14c [RT] KOG0598 Ribosomal protein S6 kinase and relat... 77 6e-14
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 77 6e-14
Hs4506095 [T] KOG0665 Jun-N-terminal kinase (JNK) 77 6e-14
Hs22055520 [R] KOG0584 Serine/threonine protein kinase 77 6e-14
Hs20986523 [T] KOG0665 Jun-N-terminal kinase (JNK) 77 6e-14
CE26422 [D] KOG0600 Cdc2-related protein kinase 77 6e-14
At5g55090 [T] KOG0198 MEKK and related serine/threonine protein ... 77 6e-14
At5g47850 [T] KOG1187 Serine/threonine protein kinase 77 6e-14
At5g20050 [T] KOG1187 Serine/threonine protein kinase 77 6e-14
At4g35030 [T] KOG1187 Serine/threonine protein kinase 77 6e-14
At4g26890 [T] KOG0198 MEKK and related serine/threonine protein ... 77 6e-14
At3g01090 [T] KOG0583 Serine/threonine protein kinase 77 6e-14
At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 6e-14
At2g30740 [T] KOG1187 Serine/threonine protein kinase 77 6e-14
At2g18170 [T] KOG0660 Mitogen-activated protein kinase 77 6e-14
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 6e-14
7303804 [R] KOG0663 Protein kinase PITSLRE and related kinases 77 6e-14
7298087 [T] KOG0660 Mitogen-activated protein kinase 77 6e-14
YPR161c [D] KOG0600 Cdc2-related protein kinase 77 8e-14
SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase 77 8e-14
SPAC17G8.14c [T] KOG0694 Serine/threonine protein kinase 77 8e-14
Hs4506081 [T] KOG0665 Jun-N-terminal kinase (JNK) 77 8e-14
Hs20986510 [T] KOG0665 Jun-N-terminal kinase (JNK) 77 8e-14
Hs20986506 [T] KOG0665 Jun-N-terminal kinase (JNK) 77 8e-14
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 77 8e-14
ECU08g0230 [R] KOG0594 Protein kinase PCTAIRE and related kinases 77 8e-14
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 77 8e-14
CE21234 [T] KOG0194 Protein tyrosine kinase 77 8e-14
CE08727 [G] KOG0658 Glycogen synthase kinase-3 77 8e-14
At5g55560 [R] KOG0584 Serine/threonine protein kinase 77 8e-14
At3g61160 [G] KOG0658 Glycogen synthase kinase-3 77 8e-14
At2g46070 [T] KOG0660 Mitogen-activated protein kinase 77 8e-14
At1g70460 [T] KOG1187 Serine/threonine protein kinase 77 8e-14
At1g67890 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 8e-14
At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GT... 77 8e-14
7292375 [R] KOG0594 Protein kinase PCTAIRE and related kinases 77 8e-14
YAL017w [T] KOG1152 Signal transduction serine/threonine kinase ... 76 1e-13
SPBC19F8.07 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polyme... 76 1e-13
HsM20070143 [T] KOG0665 Jun-N-terminal kinase (JNK) 76 1e-13
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 76 1e-13
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 76 1e-13
Hs4504357 [T] KOG0197 Tyrosine kinases 76 1e-13
Hs21237739 [T] KOG0665 Jun-N-terminal kinase (JNK) 76 1e-13
Hs21237736 [T] KOG0665 Jun-N-terminal kinase (JNK) 76 1e-13
Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 76 1e-13
Hs13653487 [T] KOG0197 Tyrosine kinases 76 1e-13
CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases 76 1e-13
At5g26751 [G] KOG0658 Glycogen synthase kinase-3 76 1e-13
At5g01810 [T] KOG0583 Serine/threonine protein kinase 76 1e-13
At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GT... 76 1e-13
At2g38910 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 76 1e-13
At1g50700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 76 1e-13
YPR054w [T] KOG0660 Mitogen-activated protein kinase 76 1e-13
YNR047w [R] KOG0610 Putative serine/threonine protein kinase 76 1e-13
SPBC119.08 [T] KOG0660 Mitogen-activated protein kinase 76 1e-13
SPAC31G5.09c [T] KOG0660 Mitogen-activated protein kinase 76 1e-13
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 76 1e-13
CE08385 [T] KOG0194 Protein tyrosine kinase 76 1e-13
At5g38260 [T] KOG1187 Serine/threonine protein kinase 76 1e-13
At4g36450 [T] KOG0660 Mitogen-activated protein kinase 76 1e-13
At3g50500 [T] KOG0583 Serine/threonine protein kinase 76 1e-13
At2g05060 [T] KOG0198 MEKK and related serine/threonine protein ... 76 1e-13
At1g07150 [T] KOG0198 MEKK and related serine/threonine protein ... 76 1e-13
At1g06390 [G] KOG0658 Glycogen synthase kinase-3 76 1e-13
YCR091w [R] KOG0610 Putative serine/threonine protein kinase 75 2e-13
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 75 2e-13
SPBPI064 [G] KOG0658 Glycogen synthase kinase-3 75 2e-13
Hs4885489 [T] KOG0192 Tyrosine kinase specific for activated (GT... 75 2e-13
CE29092 [T] KOG0694 Serine/threonine protein kinase 75 2e-13
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 75 2e-13
At4g02630 [T] KOG1187 Serine/threonine protein kinase 75 2e-13
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 75 2e-13
At2g41930 [T] KOG0198 MEKK and related serine/threonine protein ... 75 2e-13
At1g17540 [T] KOG1187 Serine/threonine protein kinase 75 2e-13
Hs4758128_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 75 2e-13
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 75 2e-13
Hs4506785 [T] KOG0660 Mitogen-activated protein kinase 75 2e-13
Hs4506103 [J] KOG1033 eIF-2alpha kinase PEK/EIF2AK3 75 2e-13
>YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 515
Score = 460 bits (1184), Expect = e-129
Identities = 237/373 (63%), Positives = 286/373 (76%), Gaps = 10/373 (2%)
Query: 119 PTTRDAPMSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSG 178
P + +SL P S+ D TL+ + N IQL++LV+L KIGAGNSG
Sbjct: 150 PVENEHSISLPPLEESLSPAAADLKDTLS------GTSNGNYIQLQDLVQLGKIGAGNSG 203
Query: 179 TVVKTLHVPDSRIIAKKTIPVE-NKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPST 237
TVVK LHVPDS+I+AKKTIPVE N + NQLVREL+I+KNV H+NI+ FYGA+YN
Sbjct: 204 TVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHI 263
Query: 238 TNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYL 297
NEI+ILMEY DCGSLDKILSVY+ R VS K +WFNE+ +S+I++ VLNGL +L
Sbjct: 264 NNEIIILMEYSDCGSLDKILSVYKRFVQRGTVS--SKKTWFNELTISKIAYGVLNGLDHL 321
Query: 298 YDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRY 357
Y YKIIHRDIKPSN+LINSKG +K+CDFGVS LINS+ADTFVGTSTYMSPERIQG Y
Sbjct: 322 YRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINSIADTFVGTSTYMSPERIQGNVY 381
Query: 358 TTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTD 417
+ KGDVWSLGLMIIEL +GEFPLGGH+DTP+GILDLLQRIVNEP+P+L K+ YS EMTD
Sbjct: 382 SIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTD 441
Query: 418 FVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMIRREET 477
FVNRCCIK ER RSS+ EL+ HD I KY + K FRHWC+K+K +IKEDK I+RE
Sbjct: 442 FVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDK-FRHWCRKIKSKIKEDKRIKREAL 500
Query: 478 ERSKIEKRQLEKA 490
+R+K+EK+Q E++
Sbjct: 501 DRAKLEKKQSERS 513
>Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 393
Score = 228 bits (580), Expect = 2e-59
Identities = 137/374 (36%), Positives = 203/374 (53%), Gaps = 65/374 (17%)
Query: 127 SLTPTGVSMMQQETDETATLTTQIARLS--LTPENGI---QLENLVRLSKIGAGNSGTVV 181
S T + +Q++ +E Q RL LT + + + ++ ++S++GAGN G V
Sbjct: 24 SSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVF 83
Query: 182 KTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEI 241
K H P ++A+K I +E K ++NQ++REL ++ ++ IVGFYGAFY+ EI
Sbjct: 84 KVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNS-PYIVGFYGAFYSDG---EI 139
Query: 242 VILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCY 301
I ME+MD GSLD++L K E L ++S V+ GL YL + +
Sbjct: 140 SICMEHMDGGSLDQVLK---------------KAGRIPEQILGKVSIAVIKGLTYLREKH 184
Query: 302 KIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKG 361
KI+HRD+KPSNIL+NS+G++K+CDFGVS LI+S+A++FVGT +YMSPER+QG Y+ +
Sbjct: 185 KIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQS 244
Query: 362 DVWSLGLMIIELSSGEFPL-------------------------------------GGHH 384
D+WS+GL ++E++ G +P+ G
Sbjct: 245 DIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDS 304
Query: 385 DTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
P I +LL IVNEP PKL +S+E DFVN+C IK R+ LK+L+ H FI
Sbjct: 305 RPPMAIFELLDYIVNEPPPKLPSGV-FSLEFQDFVNKCLIKNPAERADLKQLMVHAFI-- 361
Query: 445 YNNRDTIAKEFRHW 458
D +F W
Sbjct: 362 -KRSDAEEVDFAGW 374
>7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 396
Score = 222 bits (565), Expect = 1e-57
Identities = 131/302 (43%), Positives = 180/302 (59%), Gaps = 41/302 (13%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD 223
E+L +L ++G+GN G V+K H I+A+K I +E K +K Q++REL ++ +
Sbjct: 85 EDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECN-FP 143
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
+IVGFYGAFY+ EI I MEYMD GSLD IL + E L
Sbjct: 144 HIVGFYGAFYSDG---EISICMEYMDGGSLDLILK---------------RAGRIPESIL 185
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGT 343
RI+ VL GL YL D + IIHRD+KPSNIL+NS G++KICDFGVS LI+S+A++FVGT
Sbjct: 186 GRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGT 245
Query: 344 STYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPL-------------------GGHH 384
+YMSPER+QG Y+ + D+WSLGL ++E++ G +P+ G
Sbjct: 246 RSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPT 305
Query: 385 DTPE--GILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
D P I +LL IVNEP PKL +++ +S E DFV+ C K+ R+ LK L+ H +I
Sbjct: 306 DEPRAMAIFELLDYIVNEPPPKL-EHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI 364
Query: 443 CK 444
K
Sbjct: 365 RK 366
>Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 400
Score = 215 bits (547), Expect = 1e-55
Identities = 128/342 (37%), Positives = 189/342 (54%), Gaps = 65/342 (19%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD 223
++ R+S++GAGN G V K H P I+A+K I +E K ++NQ++REL ++ ++
Sbjct: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNS-P 128
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
IVGFYGAFY+ EI I ME+MD GSLD++L + E L
Sbjct: 129 YIVGFYGAFYSDG---EISICMEHMDGGSLDQVLK---------------EAKRIPEEIL 170
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGT 343
++S VL GL YL + ++I+HRD+KPSNIL+NS+G++K+CDFGVS LI+S+A++FVGT
Sbjct: 171 GKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT 230
Query: 344 STYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPL-----------------GGHHDT 386
+YM+PER+QG Y+ + D+WS+GL ++EL+ G +P+ G
Sbjct: 231 RSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGE 290
Query: 387 PE------------------------GILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRC 422
P I +LL IVNEP PKL N ++ + +FVN+C
Sbjct: 291 PHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKL-PNGVFTPDFQEFVNKC 349
Query: 423 CIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHW-CKKVK 463
IK R+ LK L H FI + + +F W CK ++
Sbjct: 350 LIKNPAERADLKMLTNHTFIKRSEVEEV---DFAGWLCKTLR 388
>SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 340
Score = 199 bits (505), Expect = 1e-50
Identities = 125/291 (42%), Positives = 175/291 (59%), Gaps = 26/291 (8%)
Query: 149 QIARLSLTPENGIQLEN--LVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLK 206
Q A ++ P L+N L + +G GN G V H + +A+KT+ V + L+
Sbjct: 47 QCAHMNRRPAWISDLDNSSLEVVRHLGEGNGGAVSLVKH--RNIFMARKTVYVGSDSKLQ 104
Query: 207 NQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHR 266
Q++REL ++ + + IVGFYGAF N I + MEYMDCGSLD IL R
Sbjct: 105 KQILRELGVLHHCRS-PYIVGFYGAF---QYKNNISLCMEYMDCGSLDAIL--------R 152
Query: 267 KNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDF 326
+ I L +I ++ GLIYLY+ IIHRD+KPSN+++NS+G++K+CDF
Sbjct: 153 EGGPIPLDI-------LGKIINSMVKGLIYLYNVLHIIHRDLKPSNVVVNSRGEIKLCDF 205
Query: 327 GVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLG-GHHD 385
GVS L+NS+A TFVGTSTYMSPERI+GG+YT K D+WSLG+ IIEL++ E P + D
Sbjct: 206 GVSGELVNSVAQTFVGTSTYMSPERIRGGKYTVKSDIWSLGISIIELATQELPWSFSNID 265
Query: 386 TPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKEL 436
GILDLL IV E P+L + + ++ FV+ C K+ R+S ++L
Sbjct: 266 DSIGILDLLHCIVQEEPPRLPSS--FPEDLRLFVDACLHKDPTLRASPQQL 314
>Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 448
Score = 197 bits (500), Expect = 4e-50
Identities = 129/325 (39%), Positives = 180/325 (54%), Gaps = 31/325 (9%)
Query: 145 TLTTQIARLSLTPENGIQLENLVRL-SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKE 203
+L A L NG E +R +G GN GTV K HVP +I+A K I ++
Sbjct: 144 SLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITL 203
Query: 204 VLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSD 263
L+ Q++ EL I+ + I+GFYGAF+ N I I E+MD GSLD VYR
Sbjct: 204 ELQKQIMSELEILYKCDS-SYIIGFYGAFF---VENRISICTEFMDGGSLD----VYRK- 254
Query: 264 CHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKI 323
E L RI+ V+ GL YL+ KI+HRD+KPSN+L+N++G VK+
Sbjct: 255 --------------MPEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKL 299
Query: 324 CDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGH 383
CDFGVST L+NS+A T+VGT+ YM+PERI G +Y DVWSLG+ +EL+ G FP
Sbjct: 300 CDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQI 359
Query: 384 HDTPEGI--LDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDF 441
+ L LLQ IV+E +P L E +S F+ +C K+ + R + +EL+ H F
Sbjct: 360 QKNQGSLMPLQLLQCIVDEDSPVLPVGE-FSEPFVHFITQCMRKQPKERPAPEELMGHPF 418
Query: 442 ICKYNNRDTIAKEFRHW-CKKVKKR 465
I ++N D A W C+ +++R
Sbjct: 419 IVQFN--DGNAAVVSMWVCRALEER 441
>Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 438
Score = 189 bits (481), Expect = 6e-48
Identities = 126/323 (39%), Positives = 177/323 (54%), Gaps = 37/323 (11%)
Query: 145 TLTTQIARLSLTPENGIQLENLVRL-SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKE 203
+L A L NG E +R +G GN GTV K HVP +I+A K I ++
Sbjct: 144 SLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITL 203
Query: 204 VLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSD 263
L+ Q++ EL I+ + I+GFYGAF+ N I I E+MD GSLD VYR
Sbjct: 204 ELQKQIMSELEILYKCDS-SYIIGFYGAFF---VENRISICTEFMDGGSLD----VYRK- 254
Query: 264 CHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKI 323
E L RI+ V+ GL YL+ KI+HRD+KPSN+L+N++G VK+
Sbjct: 255 --------------MPEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKL 299
Query: 324 CDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGH 383
CDFGVST L+NS+A T+VGT+ YM+PERI G +Y DVWSLG+ +E+ + L
Sbjct: 300 CDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMP- 358
Query: 384 HDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFIC 443
L LLQ IV+E +P L E +S F+ +C K+ + R + +EL+ H FI
Sbjct: 359 -------LQLLQCIVDEDSPVLPVGE-FSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 410
Query: 444 KYNNRDTIAKEFRHW-CKKVKKR 465
++N D A W C+ +++R
Sbjct: 411 QFN--DGNAAVVSMWVCRALEER 431
>Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 467
Score = 189 bits (481), Expect = 6e-48
Identities = 126/323 (39%), Positives = 177/323 (54%), Gaps = 37/323 (11%)
Query: 145 TLTTQIARLSLTPENGIQLENLVRL-SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKE 203
+L A L NG E +R +G GN GTV K HVP +I+A K I ++
Sbjct: 144 SLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITL 203
Query: 204 VLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSD 263
L+ Q++ EL I+ + I+GFYGAF+ N I I E+MD GSLD VYR
Sbjct: 204 ELQKQIMSELEILYKCDS-SYIIGFYGAFF---VENRISICTEFMDGGSLD----VYRK- 254
Query: 264 CHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKI 323
E L RI+ V+ GL YL+ KI+HRD+KPSN+L+N++G VK+
Sbjct: 255 --------------MPEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKL 299
Query: 324 CDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGH 383
CDFGVST L+NS+A T+VGT+ YM+PERI G +Y DVWSLG+ +E+ + L
Sbjct: 300 CDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMP- 358
Query: 384 HDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFIC 443
L LLQ IV+E +P L E +S F+ +C K+ + R + +EL+ H FI
Sbjct: 359 -------LQLLQCIVDEDSPVLPVGE-FSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 410
Query: 444 KYNNRDTIAKEFRHW-CKKVKKR 465
++N D A W C+ +++R
Sbjct: 411 QFN--DGNAAVVSMWVCRALEER 431
>SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 187 bits (476), Expect = 2e-47
Identities = 117/292 (40%), Positives = 163/292 (55%), Gaps = 16/292 (5%)
Query: 166 LVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNI 225
++ ++ +G G SG+V K I A KT+ L+ QL+REL I ++ ++ I
Sbjct: 79 ILYMNSLGEGVSGSVRKCRIRGTQMIFAMKTVLAAPNTALQKQLLRELKINRSCTS-PYI 137
Query: 226 VGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSR 285
V +YGA YN + ++ I MEY GSLD I RS R E PL +
Sbjct: 138 VKYYGACYNNAEC-QLNIAMEYCGAGSLDAIYKRVRSQGGRTG-----------ERPLGK 185
Query: 286 ISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTST 345
I+F VL+GL YL+D KIIHRDIKPSNIL+ SKG VK+CDFGVS L+NSLA TF GTS
Sbjct: 186 IAFGVLSGLSYLHD-RKIIHRDIKPSNILLTSKGQVKLCDFGVSGELVNSLAGTFTGTSY 244
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
YM+PERI GG YT D+WSLGL ++E++ FP P ++LL I+N P P L
Sbjct: 245 YMAPERISGGSYTISSDIWSLGLTLMEVALNRFPFPPEGSPPPMPIELLSYIINMPPPLL 304
Query: 406 SKNE--HYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEF 455
+ +S F+ C K++ R ++++ H ++ + +EF
Sbjct: 305 PQEPGIKWSKSFQHFLCVCLDKDKTRRPGPQKMLTHPWVKAFERIHVDMEEF 356
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 187 bits (476), Expect = 2e-47
Identities = 119/331 (35%), Positives = 182/331 (54%), Gaps = 31/331 (9%)
Query: 120 TTRDAPMSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGT 179
T +D + + GV ++ Q L ++ ++ + L +L + IG G+SG
Sbjct: 31 TFKDGDLRVNKDGVRIISQ-------LEPEVLSPIKPADDQLSLSDLDMVKVIGKGSSGV 83
Query: 180 VVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTN 239
V H + A K I + E ++ + +EL I ++ S N+V Y +FY+
Sbjct: 84 VQLVQHKWTGQFFALKVIQLNIDEAIRKAIAQELKINQS-SQCPNLVTSYQSFYD---NG 139
Query: 240 EIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYD 299
I +++EYMD GSL L ++ + LS I VL GLIYL+
Sbjct: 140 AISLILEYMDGGSLADFLKSVKA---------------IPDSYLSAIFRQVLQGLIYLHH 184
Query: 300 CYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS--LADTFVGTSTYMSPERIQGGRY 357
IIHRD+KPSN+LIN +G+VKI DFGVST + N+ LA+TFVGT YMSPERI G +Y
Sbjct: 185 DRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVGTYNYMSPERIVGNKY 244
Query: 358 TTKGDVWSLGLMIIELSSGEFPLG--GHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEM 415
K D+WSLGL+++E ++G+FP +T + +L++ IV++P P L ++S E+
Sbjct: 245 GNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQPPPALPSG-NFSPEL 303
Query: 416 TDFVNRCCIKEERGRSSLKELICHDFICKYN 446
+ F++ C K+ RSS KEL+ H F+ KY+
Sbjct: 304 SSFISTCLQKDPNSRSSAKELMEHPFLNKYD 334
>CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 387
Score = 187 bits (474), Expect = 4e-47
Identities = 123/358 (34%), Positives = 180/358 (49%), Gaps = 66/358 (18%)
Query: 138 QETDETATLTTQIARLSLTPENGIQLENLVRLSK---------------IGAGNSGTVVK 182
+E T L Q+ +L LT +L +++ + +G GN G V K
Sbjct: 30 EEATATVPLEEQLKKLGLTEPQTQRLSEFLQVKEGIKELSEDMLQTEGELGHGNGGVVNK 89
Query: 183 TLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIV 242
+H I+A+K + +E K ++ Q+V+EL ++ ++ IVGFYGAF + N+I
Sbjct: 90 CVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNS-PFIVGFYGAFVD---NNDIS 145
Query: 243 ILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYK 302
I MEYMD SLD +L K E + RIS V+ GL YL D K
Sbjct: 146 ICMEYMDGLSLDIVLK---------------KVGRLPEKFVGRISVAVVRGLTYLKDEIK 190
Query: 303 IIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGD 362
I+HRD+KPSN+L+NS G++K+CDFGVS LI+S+A++FVGT +YM+PER+ G YT D
Sbjct: 191 ILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTISSD 250
Query: 363 VWSLGLMIIELSSGEFP---------------------LGGHHDTPE----------GIL 391
+WS GL ++EL G +P L + P I
Sbjct: 251 IWSFGLSLVELLIGRYPVPAPSQAEYATMFNVAENEIELADSLEEPNYHPPSNPASMAIF 310
Query: 392 DLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRD 449
++L IVN P P L K ++ E+ FV++C K R++LK L F +Y + D
Sbjct: 311 EMLDYIVNGPPPTLPK-RFFTDEVIGFVSKCLRKLPSERATLKSLTADVFFTQYADHD 367
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 186 bits (473), Expect = 5e-47
Identities = 110/276 (39%), Positives = 162/276 (57%), Gaps = 24/276 (8%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG+G S V + +H+P+ RI+A K I + +E + QL+ E+ + H+ +V F+GA
Sbjct: 89 IGSGASSVVQRAIHIPNHRILALKKINIFEREK-RQQLLTEIRTLCEAPCHEGLVDFHGA 147
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVL 291
FY+P + +I I +EYM+ GSL IL V T E LS + +L
Sbjct: 148 FYSPDS-GQISIALEYMNGGSLADILKV---------------TKKIPEPVLSSLFHKLL 191
Query: 292 NGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTYMSP 349
GL YL+ ++HRDIKP+N+LIN KG+ KI DFG+S L NS+A TFVGT TYMSP
Sbjct: 192 QGLSYLHGVRHLVHRDIKPANLLINLKGEPKITDFGISAGLENSMAMCATFVGTVTYMSP 251
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE 409
ERI+ Y+ D+WSLGL + E +GEFP + EG ++L+ +I+++P+P K E
Sbjct: 252 ERIRNDSYSYPADIWSLGLALFECGTGEFP----YIANEGPVNLMLQILDDPSPTPPKQE 307
Query: 410 HYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKY 445
+S E F++ C K+ R + +L+ H FI K+
Sbjct: 308 -FSPEFCSFIDACLQKDPDARPTADQLLSHPFITKH 342
>SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 605
Score = 183 bits (464), Expect = 6e-46
Identities = 121/335 (36%), Positives = 172/335 (51%), Gaps = 36/335 (10%)
Query: 144 ATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKE 203
A L ++ S I + +++L ++G GN G V K LH P +A K I + +E
Sbjct: 298 AVLNSEGVNFSSGSSFRINMSEIIKLEELGKGNYGVVYKALHQPTGVTMALKEIRLSLEE 357
Query: 204 VLKNQLVRELTIM-KNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRS 262
NQ++ EL I+ K VS + IV FYGAF+ + I MEYMD GS+DK+ +
Sbjct: 358 ATFNQIIMELDILHKAVSPY--IVDFYGAFF---VEGSVFICMEYMDAGSMDKLYAGGIK 412
Query: 263 DCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVK 322
D E L+R ++ V+ GL L + + IIHRD+KP+N+L+NS G VK
Sbjct: 413 D----------------EGVLARTAYAVVQGLKTLKEEHNIIHRDVKPTNVLVNSNGQVK 456
Query: 323 ICDFGVSTTLINSLADTFVGTSTYMSPERIQGG-------RYTTKGDVWSLGLMIIELSS 375
+CDFGVS L+ S++ T +G +YM+PERI+ G YT + DVWSLGL I+E++
Sbjct: 457 LCDFGVSGNLVASISKTNIGCQSYMAPERIRVGGPTNGVLTYTVQADVWSLGLTILEMAL 516
Query: 376 GEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKE 435
G +P T I L I + P L + +S E DFVN+C K R E
Sbjct: 517 GAYPYPPESYT--SIFAQLSAICDGDPPSLP--DSFSPEARDFVNKCLNKNPSLRPDYHE 572
Query: 436 LICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDK 470
L H ++ KY N D + W K K E +
Sbjct: 573 LANHPWLLKYQNADV---DMASWAKGALKEKGEKR 604
>YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 668
Score = 177 bits (448), Expect = 4e-44
Identities = 117/324 (36%), Positives = 176/324 (54%), Gaps = 31/324 (9%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
I L+ L L ++G GN G V K LH P + I+A K + +E E Q++ EL ++ +
Sbjct: 355 ITLDELEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRLELDEAKFRQILMELEVLHKCN 414
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
+ IV FYGAF+ + + MEYMD GSLDKI S + +E
Sbjct: 415 S-PYIVDFYGAFF---IEGAVYMCMEYMDGGSLDKIYDE------------SSEIGGIDE 458
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINS-KGDVKICDFGVSTTLINSLADT 339
L+ I+ V++GL L + + IIHRD+KP+NIL ++ +G VK+CDFGVS L+ SLA T
Sbjct: 459 PQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAKT 518
Query: 340 FVGTSTYMSPERIQG-----GRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLL 394
+G +YM+PERI+ YT + D+WSLGL I+E++ G +P +T + I L
Sbjct: 519 NIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPY--PPETYDNIFSQL 576
Query: 395 QRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
IV+ P P+L ++ +S + DFV+ C K R + L H ++ KY N+D
Sbjct: 577 SAIVDGPPPRL-PSDKFSSDAQDFVSLCLQKIPERRPTYAALTEHPWLVKYRNQDV---- 631
Query: 455 FRHWCKKVKKRIKEDKMIRREETE 478
H + + +R++ I RE E
Sbjct: 632 --HMSEYITERLERRNKILRERGE 653
>At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 356
Score = 174 bits (440), Expect = 4e-43
Identities = 107/293 (36%), Positives = 161/293 (54%), Gaps = 23/293 (7%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
I E+L + IG G+ G V H + A K I + +E ++ Q+V+EL I + S
Sbjct: 65 ITAEDLETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASS 124
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
++V Y +FY+ + +++EYMD GSL ++ ++ +++ CK
Sbjct: 125 QCPHVVVCYHSFYHNGAFS---LVLEYMDRGSLADVIRQVKTILE-PYLAVVCKQ----- 175
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--D 338
VL GL+YL++ +IHRDIKPSN+L+N KG+VKI DFGVS +L +S+ D
Sbjct: 176 ---------VLLGLVYLHNERHVIHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQRD 226
Query: 339 TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHD--TPEGILDLLQR 396
TFVGT YMSPERI G Y D+WSLG+ ++E + G FP D P +LL
Sbjct: 227 TFVGTYNYMSPERISGSTYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLAA 286
Query: 397 IVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRD 449
IV P P + ++ +S E FV+ C K+ R+S +L+ H FI K+ ++D
Sbjct: 287 IVENP-PPTAPSDQFSPEFCSFVSACIQKDPPARASSLDLLSHPFIKKFEDKD 338
>Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 258
Score = 171 bits (432), Expect = 3e-42
Identities = 108/264 (40%), Positives = 152/264 (56%), Gaps = 30/264 (11%)
Query: 205 LKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDC 264
L+ Q++ EL I+ + I+GFYGAF+ N I I E+MD GSLD VYR
Sbjct: 15 LQKQIMSELEILYKCDS-SYIIGFYGAFF---VENRISICTEFMDGGSLD----VYRK-- 64
Query: 265 HRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKIC 324
E L RI+ V+ GL YL+ KI+HRD+KPSN+L+N++G VK+C
Sbjct: 65 -------------MPEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLC 110
Query: 325 DFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHH 384
DFGVST L+NS+A T+VGT+ YM+PERI G +Y DVWSLG+ +EL+ G FP
Sbjct: 111 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ 170
Query: 385 DTPEGI--LDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+ L LLQ IV+E +P L E +S F+ +C K+ + R + +EL+ H FI
Sbjct: 171 KNQGSLMPLQLLQCIVDEDSPVLPVGE-FSEPFVHFITQCMRKQPKERPAPEELMGHPFI 229
Query: 443 CKYNNRDTIAKEFRHW-CKKVKKR 465
++N D A W C+ +++R
Sbjct: 230 VQFN--DGNAAVVSMWVCRALEER 251
>At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 354
Score = 170 bits (431), Expect = 4e-42
Identities = 116/315 (36%), Positives = 170/315 (53%), Gaps = 27/315 (8%)
Query: 142 ETATLTTQIARLSLTP-ENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVE 200
+T +L+ A + P +N + L +L + IG G+SG V H + A K I +
Sbjct: 43 QTVSLSEPGAPPPIEPLDNQLSLADLEVIKVIGKGSSGNVQLVKHKLTQQFFALKVIQLN 102
Query: 201 NKEVLKNQLVRELTIMKNVSAH-DNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSV 259
+E + +EL I N+S+ +V Y +FY+ + I++E+MD GSL +L
Sbjct: 103 TEESTCRAISQELRI--NLSSQCPYLVSCYQSFYHNGLVS---IILEFMDGGSLADLLK- 156
Query: 260 YRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKG 319
K E LS I VL GL Y++ +IIHRD+KPSN+LIN +G
Sbjct: 157 --------------KVGKVPENMLSAICKRVLRGLCYIHHERRIIHRDLKPSNLLINHRG 202
Query: 320 DVKICDFGVSTTLIN--SLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGE 377
+VKI DFGVS L + SLA++FVGT YMSPERI G Y+ K D+WSLGL+++E ++G+
Sbjct: 203 EVKITDFGVSKILTSTSSLANSFVGTYPYMSPERISGSLYSNKSDIWSLGLVLLECATGK 262
Query: 378 FPL--GGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKE 435
FP H + +L+ IV P P N +S E F+++C K+ R R S KE
Sbjct: 263 FPYTPPEHKKGWSSVYELVDAIVENPPPCAPSN-LFSPEFCSFISQCVQKDPRDRKSAKE 321
Query: 436 LICHDFICKYNNRDT 450
L+ H F+ + + DT
Sbjct: 322 LLEHKFVKMFEDSDT 336
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 162 bits (410), Expect = 1e-39
Identities = 118/344 (34%), Positives = 175/344 (50%), Gaps = 23/344 (6%)
Query: 127 SLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLV----RLSKIGAGNSGTVVK 182
S +P S + + E+ + + ENG + NL L +G G G+V K
Sbjct: 178 SSSPIKSSSQPKSSSESYIDLNSVRDVDQLDENGWKYANLKDRIETLGILGEGAGGSVSK 237
Query: 183 TLHVPDSRIIAKKTIPVENKEV-LKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEI 241
S+I A K I N + + Q+ REL ++ + + IV +YG F + ++ I
Sbjct: 238 CKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQS-EYIVRYYGMFTDDENSS-I 295
Query: 242 VILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCY 301
I MEYM SLD ++Y++ R +E L +I+ VL GL YL++
Sbjct: 296 YIAMEYMGGRSLD---AIYKNLLERGGR--------ISEKVLGKIAEAVLRGLSYLHE-K 343
Query: 302 KIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKG 361
K+IHRDIKP NIL+N G VK+CDFGVS +NSLA TF GTS YM+PERIQG Y+
Sbjct: 344 KVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNSLATTFTGTSFYMAPERIQGQPYSVTS 403
Query: 362 DVWSLGLMIIELSSGEFPLGGH----HDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTD 417
DVWSLGL I+E+++G+FP + P +L + E + N +S
Sbjct: 404 DVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKS 463
Query: 418 FVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKK 461
F++ C K+ R R S +++I H +I ++ ++F C K
Sbjct: 464 FIDYCLKKDSRERPSPRQMINHPWIKGQMKKNVNMEKFVRKCWK 507
>Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 399
Score = 158 bits (399), Expect = 2e-38
Identities = 116/329 (35%), Positives = 165/329 (49%), Gaps = 30/329 (9%)
Query: 130 PTGVSMMQQETDETATLTTQIARLSLTPEN--GIQLENLVRLSKIGAGNSGTVVKTLHVP 187
PTGV E T ++ + +L ++PE E+L L +IG G G+V K +H P
Sbjct: 65 PTGVQNPHIERLRTHSIESS-GKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKP 123
Query: 188 DSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEY 247
+I+A K I E + QL+ +L ++ S IV FYGA + + I ME
Sbjct: 124 SGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREG---DCWICMEL 180
Query: 248 MDCGSLDKILS-VYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHR 306
M S DK VY S E L +I+ + L +L + KIIHR
Sbjct: 181 MST-SFDKFYKYVY-----------SVLDDVIPEEILGKITLATVKALNHLKENLKIIHR 228
Query: 307 DIKPSNILINSKGDVKICDFGVSTTLINSLADT-FVGTSTYMSPERIQGGR----YTTKG 361
DIKPSNIL++ G++K+CDFG+S L++S+A T G YM+PERI Y +
Sbjct: 229 DIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRS 288
Query: 362 DVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE--HYSIEMTDFV 419
DVWSLG+ + EL++G FP + + D L ++V P+LS +E +S +FV
Sbjct: 289 DVWSLGITLYELATGRFP----YPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFV 344
Query: 420 NRCCIKEERGRSSLKELICHDFICKYNNR 448
N C K+E R KEL+ H FI Y R
Sbjct: 345 NLCLTKDESKRPKYKELLKHPFILMYEER 373
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 156 bits (395), Expect = 6e-38
Identities = 108/307 (35%), Positives = 164/307 (53%), Gaps = 21/307 (6%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEV-LKNQLVRELTIMKNVSAH 222
+ + L +G G G+V K ++ A KTI N + + Q+ REL K+ +
Sbjct: 212 DEITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKS- 270
Query: 223 DNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMP 282
D IV +YG F + +++ I I MEYM SL+ + Y++ R +E
Sbjct: 271 DYIVQYYGMFTDEQSSS-IYIAMEYMGGKSLE---ATYKNLLKRGGR--------ISERV 318
Query: 283 LSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVG 342
+ +I+ VL GL YL++ K+IHRDIKP NIL+N KG++K+CDFGVS +NSLA TF G
Sbjct: 319 IGKIAESVLRGLSYLHE-RKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVNSLAMTFTG 377
Query: 343 TSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPE-GILDLLQRIVNEP 401
TS YM+PERIQG Y+ DVWSLGL ++E++ G FP T ++LL I+
Sbjct: 378 TSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILTF- 436
Query: 402 APKLSKNEHYSIEMT----DFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRH 457
+P+L I + F++ C K+ R R S ++++ H +I + + F
Sbjct: 437 SPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPWIVGQMKKKVNMERFVK 496
Query: 458 WCKKVKK 464
C + +K
Sbjct: 497 KCWEKEK 503
>At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 310
Score = 155 bits (391), Expect = 2e-37
Identities = 113/319 (35%), Positives = 160/319 (49%), Gaps = 40/319 (12%)
Query: 133 VSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRII 192
+S + T ++ TT +A NGI +L +L+ +G GN G V K H S I
Sbjct: 19 ISDRRFSTSSSSATTTTVAGC-----NGISACDLEKLNVLGCGNGGIVYKVRHKTTSEIY 73
Query: 193 AKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGS 252
A KT+ + + QL+RE+ I++ + +V +G F P E+ ILMEYMD G+
Sbjct: 74 ALKTVNGDMDPIFTRQLMREMEILRRTDS-PYVVKCHGIFEKP-VVGEVSILMEYMDGGT 131
Query: 253 LDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSN 312
L+ + R V+ E L+ + +L GL YL+ KI+HRDIKP+N
Sbjct: 132 LESL---------RGGVT---------EQKLAGFAKQILKGLSYLH-ALKIVHRDIKPAN 172
Query: 313 ILINSKGDVKICDFGVSTTLINSL--ADTFVGTSTYMSPERIQ-----GGRYTTKGDVWS 365
+L+NSK +VKI DFGVS L+ SL +++VGT YMSPER G GD+WS
Sbjct: 173 LLLNSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESSGGSSDIYAGDIWS 232
Query: 366 LGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP--APKLSKNEHYSIEMTDFVNRCC 423
GLM++EL G FPL P+ + EP AP E S E FV C
Sbjct: 233 FGLMMLELLVGHFPLLPPGQRPDWATLMCAVCFGEPPRAP-----EGCSEEFRSFVECCL 287
Query: 424 IKEERGRSSLKELICHDFI 442
K+ R + +L+ H F+
Sbjct: 288 RKDSSKRWTAPQLLAHPFL 306
>7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 334
Score = 154 bits (389), Expect = 3e-37
Identities = 107/301 (35%), Positives = 160/301 (52%), Gaps = 27/301 (8%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
I ++L ++ +G G G V K H ++A K IP+ +++LV +L I S
Sbjct: 41 IDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSS 100
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKIL-SVYRSDCHRKNVSISCKTSWFN 279
V FYGA Y ++ I ME M SLDK V+ D +
Sbjct: 101 DCPYTVHFYGAMYREG---DVWICMEVMST-SLDKFYPKVFLHDLRME------------ 144
Query: 280 EMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT 339
E L +I+ V++ L YL+ K+IHRD+KPSNILIN G VKICDFG+S L++S+A T
Sbjct: 145 ESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKT 204
Query: 340 F-VGTSTYMSPERI--QG--GRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLL 394
G YM+PERI QG +Y + DVWSLG+ +IE+++G +P +D + L
Sbjct: 205 IDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYP----YDNWRTPFEQL 260
Query: 395 QRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
+++V + P+L + +S E DF+ C KE R + ++L+ H FI ++ R+T E
Sbjct: 261 RQVVEDSPPRLPEGT-FSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISE 319
Query: 455 F 455
F
Sbjct: 320 F 320
>CE07399 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 343
Score = 151 bits (381), Expect = 3e-36
Identities = 111/324 (34%), Positives = 159/324 (48%), Gaps = 27/324 (8%)
Query: 132 GVSMMQQETDETATLTTQ----IARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVP 187
G+ ++ ET T+ + I + + E I +LV L ++G G G V K H
Sbjct: 12 GMKIVMPTPVETPTMNLEDRCLIKLTNESEEIEIAATDLVVLEELGKGGYGIVEKMQHRQ 71
Query: 188 DSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEY 247
I+A K I + + Q++ EL + +V FYGA + ++ I ME
Sbjct: 72 SGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREG---DVWICMEV 128
Query: 248 MDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRD 307
MD SLDK YR H + + +M LS V+ GL ++ + +IHRD
Sbjct: 129 MDT-SLDKF---YR---HAYKIGKHIPEPFIGKMALS-----VIEGLNFMKEQLNLIHRD 176
Query: 308 IKPSNILINSKGDVKICDFGVSTTLINSLADTF-VGTSTYMSPERIQG---GRYTTKGDV 363
+KPSNIL+N G VKICDFG+S L NS+A T G YM PERI G Y + DV
Sbjct: 177 VKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADV 236
Query: 364 WSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCC 423
WSLG+ IIE++ G P + TP + L+++V EP PKL +S++ FV RC
Sbjct: 237 WSLGITIIEIAVGTHPY-ANWKTP---FEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCL 292
Query: 424 IKEERGRSSLKELICHDFICKYNN 447
K+ R EL+ F+ + N
Sbjct: 293 EKDYNERPKYPELLAMPFMEQARN 316
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 147 bits (372), Expect = 3e-35
Identities = 99/338 (29%), Positives = 174/338 (51%), Gaps = 31/338 (9%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L K+G G+ G+V K +H +++A K +PVE+ ++++E++IM+ + +V +
Sbjct: 30 LEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEISIMQQCDS-PYVVKY 85
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG+++ ++ I+MEY GS+ I+ + ++ K++
Sbjct: 86 YGSYFK---NTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKST------------ 130
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+ KI HRDIK NIL+N++G K+ DFGV+ L +++A +T +GT +
Sbjct: 131 --LKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFW 187
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE IQ Y D+WSLG+ IE++ G+ P H + + I P P
Sbjct: 188 MAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHP-----MRAIFMIPTNPPPTFR 242
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRI 466
K E +S + TDFV +C +K R++ +L+ H FI K +I ++ ++K +
Sbjct: 243 KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAKR 301
Query: 467 KEDKMIRREETERSKIEKRQLEKAALAVTAARSSSTRR 504
E++ EE E + ++ +L+ + T+ S T R
Sbjct: 302 HEEQQRELEEEEENS-DEDELDSHTMVKTSVESVGTMR 338
>Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 334
Score = 147 bits (371), Expect = 4e-35
Identities = 100/301 (33%), Positives = 156/301 (51%), Gaps = 27/301 (8%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
++ ++L + ++G G G V K HVP +I+A K I + +L+ +L I
Sbjct: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTV 107
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
V FYGA + ++ I ME MD SLDK + K E
Sbjct: 108 DCPFTVTFYGALFREG---DVWICMELMDT-SLDKFYK-----------QVIDKGQTIPE 152
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF 340
L +I+ ++ L +L+ +IHRD+KPSN+LIN+ G VK+CDFG+S L++S+A T
Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212
Query: 341 -VGTSTYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLL 394
G YM+PERI Q G Y+ K D+WSLG+ +IEL+ FP +D+ L
Sbjct: 213 DAGCKPYMAPERINPELNQKG-YSVKSDIWSLGITMIELAILRFP----YDSWGTPFQQL 267
Query: 395 QRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
+++V EP+P+L ++ +S E DF ++C K + R + EL+ H F + ++ T
Sbjct: 268 KQVVEEPSPQLPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVAS 326
Query: 455 F 455
F
Sbjct: 327 F 327
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 146 bits (368), Expect = 8e-35
Identities = 98/338 (28%), Positives = 172/338 (49%), Gaps = 31/338 (9%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L K+G G+ G+V K +H +++A K +PVE+ ++++E++IM+ + +V +
Sbjct: 30 LEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---LQEIIKEISIMQQCDS-PYVVKY 85
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG+++ ++ I+MEY GS+ I+ + ++ K++
Sbjct: 86 YGSYFK---NTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKST------------ 130
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+ KI HRDIK NIL+N++G K+ DFGV+ L +++A +T +GT +
Sbjct: 131 --LKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFW 187
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE IQ Y D+WSLG+ IE++ G+ P H + + I P P
Sbjct: 188 MAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHP-----MRAIFMIPTNPPPTFR 242
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRI 466
K E +S + TDFV +C +K R++ +L+ H FI K +I ++ ++K +
Sbjct: 243 KPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI-KNAKPVSILRDLITEAMEIKAK- 300
Query: 467 KEDKMIRREETERSKIEKRQLEKAALAVTAARSSSTRR 504
+ D+ R E E ++ +L+ + T+ T R
Sbjct: 301 RHDEQQRELEEEEENSDEDELDSHTMVKTSVGECGTMR 338
>At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 366
Score = 144 bits (363), Expect = 3e-34
Identities = 105/288 (36%), Positives = 153/288 (52%), Gaps = 37/288 (12%)
Query: 165 NLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDN 224
+LVR ++IG+G GTV K +H P SR+ A K I ++E ++ Q+ RE+ I+++V+ H N
Sbjct: 78 DLVRGNRIGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRRQICREIEILRDVN-HPN 136
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
+V + F EI +L+E+MD GSL+ + E L+
Sbjct: 137 VVKCHEMF---DQNGEIQVLLEFMDKGSLE-------------------GAHVWKEQQLA 174
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL--ADTFVG 342
+S +L+GL YL+ + I+HRDIKPSN+LINS +VKI DFGVS L ++ ++ VG
Sbjct: 175 DLSRQILSGLAYLHSRH-IVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVG 233
Query: 343 TSTYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRI 397
T YMSPERI QG GD+WSLG+ I+E G FP L+ I
Sbjct: 234 TIAYMSPERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPFPVSRQGDWA--SLMCAI 291
Query: 398 VNEPAPKLSKNEHYSIEMTDFVNRCCIKEERG-RSSLKELICHDFICK 444
P+ S E F++ CC++ E G R S +L+ H FI +
Sbjct: 292 CMSQPPEAPATA--SPEFRHFIS-CCLQREPGKRRSAMQLLQHPFILR 336
>HsM4506099 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 318
Score = 144 bits (362), Expect = 4e-34
Identities = 111/315 (35%), Positives = 159/315 (50%), Gaps = 33/315 (10%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
++ ++LV +S++G G G V K H I+A K I + +L+ +L I
Sbjct: 30 VEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTV 89
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
V FYGA + ++ I ME MD SLDK YR KN++I E
Sbjct: 90 DCFYTVTFYGALFREG---DVWICMELMDT-SLDKF---YRKVLD-KNMTIP-------E 134
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF 340
L I+ ++ L +L+ +IHRD+KPSN+LIN +G VK+CDFG+S L++S+A T
Sbjct: 135 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 194
Query: 341 -VGTSTYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLL 394
G YM+PERI Q G Y K DVWSLG+ +IE++ FP TP L
Sbjct: 195 DAGCKPYMAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFPYES-WGTP---FQQL 249
Query: 395 QRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
+++V EP+P+L + +S E DF +C K R S EL+ H F + + T
Sbjct: 250 KQVVEEPSPQLPA-DRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAA 308
Query: 455 FRHWCKKVKKRIKED 469
F VKK + ED
Sbjct: 309 F------VKKILGED 317
>Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 278
Score = 144 bits (362), Expect = 4e-34
Identities = 99/291 (34%), Positives = 150/291 (51%), Gaps = 27/291 (9%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
++G G G V K HVP +I+A K I + +L+ +L I V FYG
Sbjct: 2 ELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYG 61
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
A + ++ I ME MD SLDK + K E L +I+ +
Sbjct: 62 ALFREG---DMWICMELMDT-SLDKFYK-----------QVIDKGQTIPEDILGKIAVSI 106
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF-VGTSTYMSP 349
+ L +L+ +IHRD+KPSN+LIN+ G VK+CDFG+S L++S+A T G YM+P
Sbjct: 107 VKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAP 166
Query: 350 ERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPK 404
ERI Q G Y+ K D+WSLG+ +IEL+ FP +D+ L+++V EP+P+
Sbjct: 167 ERINPELNQKG-YSVKSDIWSLGITMIELAILRFP----YDSWGTPFQQLKQVVEEPSPQ 221
Query: 405 LSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEF 455
L ++ +S E DF ++C K + R + EL+ H F + ++ T F
Sbjct: 222 LPADK-FSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASF 271
>CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 363
Score = 144 bits (362), Expect = 4e-34
Identities = 103/286 (36%), Positives = 144/286 (50%), Gaps = 30/286 (10%)
Query: 165 NLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVEN---KEVLKNQLVRELTIMKNVSA 221
NL L IG GN GTV K H ++IA K I N +E ++ L+RE +
Sbjct: 65 NLQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNNIGHREQIR--LLREHDTIVKSEK 122
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILS-VYRSDCHRKNVSISCKTSWFNE 280
NIV FYGA ++ + I ME MD S+D + VY K S NE
Sbjct: 123 GPNIVKFYGAIFSEG---DCWICMELMDI-SMDLLYKRVYM-----------VKNSRLNE 167
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF 340
+ I+ C ++ L YL KIIHRD+KPSNIL++ G VK+CDFG+ L S A T
Sbjct: 168 NVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTH 227
Query: 341 -VGTSTYMSPERI-QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
G Y++PERI +Y + DVWSLG+ + E+++G+FP + + D + +V
Sbjct: 228 DAGCQPYLAPERITSSDKYDVRSDVWSLGITLYEIATGKFP----YQEWNSLFDQIATVV 283
Query: 399 NEPAPKL---SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDF 441
+ P L S + HYS+ + F+N C K+ R R L DF
Sbjct: 284 SGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDF 329
>At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 307
Score = 144 bits (362), Expect = 4e-34
Identities = 102/292 (34%), Positives = 142/292 (47%), Gaps = 34/292 (11%)
Query: 159 NGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKN 218
NGI ++ +L +G G+SG V K H I A K++ + QL RE+ I++
Sbjct: 38 NGISASDVEKLHVLGRGSSGIVYKVHHKTTGEIYALKSVNGDMSPAFTRQLAREMEILRR 97
Query: 219 VSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWF 278
+ +V G F P E+ ILMEYMD G+L+ +
Sbjct: 98 TDS-PYVVRCQGIFEKP-IVGEVSILMEYMDGGNLESLRGAV------------------ 137
Query: 279 NEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL-- 336
E L+ S +L GL YL+ KI+HRDIKP+N+L+NS+ +VKI DFGVS + SL
Sbjct: 138 TEKQLAGFSRQILKGLSYLHSL-KIVHRDIKPANLLLNSRNEVKIADFGVSKIITRSLDY 196
Query: 337 ADTFVGTSTYMSPERIQGGRYTTK----GDVWSLGLMIIELSSGEFPLGGHHDTPEGILD 392
+++VGT YMSPER GD+WS G+MI+EL G FPL P+
Sbjct: 197 CNSYVGTCAYMSPERFDSAAGENSDVYAGDIWSFGVMILELFVGHFPLLPQGQRPDWATL 256
Query: 393 LLQRIVNEP--APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+ EP AP E S E FV+ C KE R + +L+ H F+
Sbjct: 257 MCVVCFGEPPRAP-----EGCSDEFRSFVDCCLRKESSERWTASQLLGHPFL 303
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 143 bits (361), Expect = 5e-34
Identities = 90/291 (30%), Positives = 156/291 (52%), Gaps = 29/291 (9%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
K+G G+ G+V K +H S I+A K +PVE+ +++++E++IM+ + +V +YG
Sbjct: 47 KLGEGSYGSVYKAVHKESSSIVAIKLVPVESD---LHEIIKEISIMQQCDS-PYVVRYYG 102
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
+++ ++ I MEY GS+ I+ + + E ++ I
Sbjct: 103 SYFKQY---DLWICMEYCGAGSVSDIMRLRKKT--------------LTEDEIATILSDT 145
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTYMS 348
L GL+YL+ KI HRDIK +NIL+N++G K+ DFGV+ L +++A +T +GT +M+
Sbjct: 146 LQGLVYLHLRRKI-HRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMA 204
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN 408
PE I+ Y D+WSLG+ +E++ G+ P G H + + I +P P +
Sbjct: 205 PEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHP-----MRAIFMIPQKPPPSFREP 259
Query: 409 EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWC 459
+ +S E DFV++C +KE R++ EL+ H+FI +R + C
Sbjct: 260 DRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETC 310
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 143 bits (360), Expect = 7e-34
Identities = 95/338 (28%), Positives = 170/338 (50%), Gaps = 30/338 (8%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L K+G G+ G+V K +H +I+A K +PVE+ ++++E++IM+ + ++V +
Sbjct: 33 LEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD---LQEIIKEISIMQQCDS-PHVVKY 88
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG+++ ++ I+MEY GS+ I+ + + E ++ I
Sbjct: 89 YGSYFK---NTDLWIVMEYCGAGSVSDIIRL--------------RNKTLTEDEIATILQ 131
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+ KI HRDIK NIL+N++G K+ DFGV+ L +++A +T +GT +
Sbjct: 132 STLKGLEYLHFMRKI-HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFW 190
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE IQ Y D+WSLG+ IE++ G+ P H + + I P P
Sbjct: 191 MAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHP-----MRAIFMIPTNPPPTFR 245
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRI 466
K E +S TDFV +C +K R++ +L+ H F+ + +I ++ + VK +
Sbjct: 246 KPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFV-RSAKGVSILRDLINEAMDVKLKR 304
Query: 467 KEDKMIRREETERSKIEKRQLEKAALAVTAARSSSTRR 504
+E + ++ + E+ +++ + T R
Sbjct: 305 QESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVR 342
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 142 bits (359), Expect = 9e-34
Identities = 90/276 (32%), Positives = 144/276 (51%), Gaps = 29/276 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ K+G G+ G+V K +H ++A K +PV+ ++++E++IM+ + +V +
Sbjct: 66 VGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---LQEIIKEISIMQQCKSK-YVVKY 121
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG+++ S ++ I+MEY GS+ I+ R +E +S +
Sbjct: 122 YGSYFKHS---DLWIVMEYCGAGSISDIMRARRKP--------------LSEQEISAVLR 164
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+D KI HRDIK NIL+N+ G K+ DFGV+ L +++A +T +GT +
Sbjct: 165 DTLKGLQYLHDLKKI-HRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFW 223
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE I+ Y TK D+WSLG+ IE++ G P H + + I +P P
Sbjct: 224 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHP-----MRAIFMIPTKPPPTFK 278
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
K E +S E DF+ C IK+ R + L H FI
Sbjct: 279 KPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 314
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 142 bits (359), Expect = 9e-34
Identities = 90/276 (32%), Positives = 144/276 (51%), Gaps = 29/276 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ K+G G+ G+V K +H ++A K +PV+ ++++E++IM+ + +V +
Sbjct: 38 VGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---LQEIIKEISIMQQCKSK-YVVKY 93
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG+++ S ++ I+MEY GS+ I+ R +E +S +
Sbjct: 94 YGSYFKHS---DLWIVMEYCGAGSISDIMRARRKP--------------LSEQEISAVLR 136
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+D KI HRDIK NIL+N+ G K+ DFGV+ L +++A +T +GT +
Sbjct: 137 DTLKGLQYLHDLKKI-HRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFW 195
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE I+ Y TK D+WSLG+ IE++ G P H + + I +P P
Sbjct: 196 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHP-----MRAIFMIPTKPPPTFK 250
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
K E +S E DF+ C IK+ R + L H FI
Sbjct: 251 KPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 286
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 142 bits (359), Expect = 9e-34
Identities = 90/276 (32%), Positives = 144/276 (51%), Gaps = 29/276 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ K+G G+ G+V K +H ++A K +PV+ ++++E++IM+ + +V +
Sbjct: 38 VGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---LQEIIKEISIMQQCKSK-YVVKY 93
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG+++ S ++ I+MEY GS+ I+ R +E +S +
Sbjct: 94 YGSYFKHS---DLWIVMEYCGAGSISDIMRARRKP--------------LSEQEISAVLR 136
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+D KI HRDIK NIL+N+ G K+ DFGV+ L +++A +T +GT +
Sbjct: 137 DTLKGLQYLHDLKKI-HRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFW 195
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE I+ Y TK D+WSLG+ IE++ G P H + + I +P P
Sbjct: 196 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHP-----MRAIFMIPTKPPPTFK 250
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
K E +S E DF+ C IK+ R + L H FI
Sbjct: 251 KPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 286
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 142 bits (359), Expect = 9e-34
Identities = 90/276 (32%), Positives = 144/276 (51%), Gaps = 29/276 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ K+G G+ G+V K +H ++A K +PV+ ++++E++IM+ + +V +
Sbjct: 66 VGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---LQEIIKEISIMQQCKSK-YVVKY 121
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG+++ S ++ I+MEY GS+ I+ R +E +S +
Sbjct: 122 YGSYFKHS---DLWIVMEYCGAGSISDIMRARRKP--------------LSEQEISAVLR 164
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+D KI HRDIK NIL+N+ G K+ DFGV+ L +++A +T +GT +
Sbjct: 165 DTLKGLQYLHDLKKI-HRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFW 223
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE I+ Y TK D+WSLG+ IE++ G P H + + I +P P
Sbjct: 224 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHP-----MRAIFMIPTKPPPTFK 278
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
K E +S E DF+ C IK+ R + L H FI
Sbjct: 279 KPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 314
>At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 348
Score = 142 bits (359), Expect = 9e-34
Identities = 105/289 (36%), Positives = 149/289 (51%), Gaps = 35/289 (12%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAH 222
L L R+++IG+G GTV K +H P SR A K I +++ ++ Q+ RE+ I+++V H
Sbjct: 67 LSELERVNRIGSGAGGTVYKVIHTPTSRPFALKVIYGNHEDTVRRQICREIEILRSVD-H 125
Query: 223 DNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMP 282
N+V + F EI +L+E+MD GSL+ + E
Sbjct: 126 PNVVKCHDMF---DHNGEIQVLLEFMDQGSLE-------------------GAHIWQEQE 163
Query: 283 LSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL--ADTF 340
L+ +S +L+GL YL+ + I+HRDIKPSN+LINS +VKI DFGVS L ++ ++
Sbjct: 164 LADLSRQILSGLAYLHRRH-IVHRDIKPSNLLINSAKNVKIADFGVSRILAQTMDPCNSS 222
Query: 341 VGTSTYMSPERI----QGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQ 395
VGT YMSPERI GRY GDVWSLG+ I+E G FP L+
Sbjct: 223 VGTIAYMSPERINTDLNHGRYDGYAGDVWSLGVSILEFYLGRFPFAVSRQGDWA--SLMC 280
Query: 396 RIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
I P+ S E FV+ C + R S ++L+ H FI K
Sbjct: 281 AICMSQPPEAPATA--SQEFRHFVSCCLQSDPPKRWSAQQLLQHPFILK 327
>Hs21618351 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 352
Score = 142 bits (358), Expect = 1e-33
Identities = 110/315 (34%), Positives = 159/315 (49%), Gaps = 33/315 (10%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
++ ++LV +S++G G G V K H I+A K I + +L+ +L I
Sbjct: 64 VEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTV 123
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
V FYGA + ++ I ME MD SLDK YR KN++I E
Sbjct: 124 DCFYTVTFYGALFREG---DVWICMELMDT-SLDKF---YRKVLD-KNMTIP-------E 168
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF 340
L I+ ++ L +L+ +IHRD+KPSN+LIN +G VK+CDFG+S L++S+A T
Sbjct: 169 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 228
Query: 341 -VGTSTYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLL 394
G YM+PERI Q G Y K DVWSLG+ +IE++ FP TP L
Sbjct: 229 DAGCKPYMAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFPYES-WGTP---FQQL 283
Query: 395 QRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
+++V EP+P+L + +S E DF +C K R S EL+ H F + + T
Sbjct: 284 KQVVEEPSPQLPA-DRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAA 342
Query: 455 FRHWCKKVKKRIKED 469
F VK+ + ED
Sbjct: 343 F------VKEILGED 351
>Hs21618349 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 347
Score = 142 bits (358), Expect = 1e-33
Identities = 110/315 (34%), Positives = 159/315 (49%), Gaps = 33/315 (10%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
++ ++LV +S++G G G V K H I+A K I + +L+ +L I
Sbjct: 59 VEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTV 118
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
V FYGA + ++ I ME MD SLDK YR KN++I E
Sbjct: 119 DCFYTVTFYGALFREG---DVWICMELMDT-SLDKF---YRKVLD-KNMTIP-------E 163
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF 340
L I+ ++ L +L+ +IHRD+KPSN+LIN +G VK+CDFG+S L++S+A T
Sbjct: 164 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 223
Query: 341 -VGTSTYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLL 394
G YM+PERI Q G Y K DVWSLG+ +IE++ FP TP L
Sbjct: 224 DAGCKPYMAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFPYES-WGTP---FQQL 278
Query: 395 QRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
+++V EP+P+L + +S E DF +C K R S EL+ H F + + T
Sbjct: 279 KQVVEEPSPQLPA-DRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAA 337
Query: 455 FRHWCKKVKKRIKED 469
F VK+ + ED
Sbjct: 338 F------VKEILGED 346
>Hs21618347 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 318
Score = 142 bits (358), Expect = 1e-33
Identities = 110/315 (34%), Positives = 159/315 (49%), Gaps = 33/315 (10%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVS 220
++ ++LV +S++G G G V K H I+A K I + +L+ +L I
Sbjct: 30 VEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTV 89
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
V FYGA + ++ I ME MD SLDK YR KN++I E
Sbjct: 90 DCFYTVTFYGALFREG---DVWICMELMDT-SLDKF---YRKVLD-KNMTIP-------E 134
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF 340
L I+ ++ L +L+ +IHRD+KPSN+LIN +G VK+CDFG+S L++S+A T
Sbjct: 135 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 194
Query: 341 -VGTSTYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLL 394
G YM+PERI Q G Y K DVWSLG+ +IE++ FP TP L
Sbjct: 195 DAGCKPYMAPERINPELNQKG-YNVKSDVWSLGITMIEMAILRFPYES-WGTP---FQQL 249
Query: 395 QRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
+++V EP+P+L + +S E DF +C K R S EL+ H F + + T
Sbjct: 250 KQVVEEPSPQLPA-DRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAA 308
Query: 455 FRHWCKKVKKRIKED 469
F VK+ + ED
Sbjct: 309 F------VKEILGED 317
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 141 bits (356), Expect = 2e-33
Identities = 92/280 (32%), Positives = 149/280 (52%), Gaps = 28/280 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L+++G G+ G+V K + S I+A K I + E ++ E+ +++ + H N+V +
Sbjct: 252 LNELGKGSYGSVYKARDLKTSEIVAVKVISLTEGEEGYEEIRGEIEMLQQCN-HPNVVRY 310
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
G++ + + I+MEY GS+ +++V ++ C+ +
Sbjct: 311 LGSYQGE---DYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREA------------ 355
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+ YK+ HRDIK NIL+ +G+VK+ DFGV+ L +++ +TF+GT +
Sbjct: 356 --LKGLAYLHSIYKV-HRDIKGGNILLTEQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHW 412
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE IQ RY K DVW+LG+ IE++ G P H + +L I EPAP L
Sbjct: 413 MAPEVIQENRYDGKVDVWALGVSAIEMAEGLPPRSSVHP-----MRVLFMISIEPAPMLE 467
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI--CK 444
E +S+ DFV +C KE R R + E++ H F+ CK
Sbjct: 468 DKEKWSLVFHDFVAKCLTKEPRLRPTAAEMLKHKFVERCK 507
>CE16527 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 359
Score = 139 bits (350), Expect = 1e-32
Identities = 105/287 (36%), Positives = 146/287 (50%), Gaps = 26/287 (9%)
Query: 165 NLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDN 224
NL LS++GAG GTV K H R+IA K I N L T MK+ + N
Sbjct: 63 NLRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYNNICDQTRLLKEHDTHMKSENV-PN 121
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILS-VYRSDCHRKNVSISCKTSWFNEMPL 283
IV F+GA ++ + I ME MD S+D + VY S K S NE +
Sbjct: 122 IVKFFGACFSEG---DCWICMELMDI-SIDFLYKRVY-----------SVKKSRLNENII 166
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF-VG 342
I+ C+++ L YL IHRD+KPSNILIN+ GDVK+CDFG+ L+ S A T G
Sbjct: 167 GHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICGDLVGSYAITVEAG 226
Query: 343 TSTYMSPERIQG-GRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
Y++PERI+ +Y + DVWSLG+ + E+++G +P G + E I + +VN
Sbjct: 227 CVQYLAPERIENMDKYDIRSDVWSLGITLYEIATGVYPYRGWSNQMEHI----EIVVNGD 282
Query: 402 APKLSKNE---HYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKY 445
+P L +N HY+ + F+N C K + R L F Y
Sbjct: 283 SPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFYKMY 329
>7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 424
Score = 139 bits (349), Expect = 1e-32
Identities = 97/279 (34%), Positives = 149/279 (52%), Gaps = 25/279 (8%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
+IG G G V K +++A K I E + QL+ +L ++ + IV FYG
Sbjct: 127 EIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIVQFYG 186
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
A + + I ME MD SLDK Y + ++++ E L++I+
Sbjct: 187 ALFKEG---DCWICMELMDT-SLDKFYK-YIYEKQQRHIP---------ESILAKITVAT 232
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT-FVGTSTYMSP 349
+N L YL + KIIHRD+KPSNIL++ +GD+K+CDFG+S L++S+A T G YM+P
Sbjct: 233 VNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAP 292
Query: 350 ERIQGGR---YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
ERI R Y + DVWSLG+ ++E+++G FP + + + + L ++V P+L
Sbjct: 293 ERIDPERAKGYDVRSDVWSLGITLMEVATGNFP----YRKWDSVFEQLCQVVQGEPPRLL 348
Query: 407 KNEH---YSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+ + +S E DFVN C IK+E R L+ FI
Sbjct: 349 TSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI 387
>At3g15220 [T] KOG0201 Serine/threonine protein kinase
Length = 690
Score = 138 bits (347), Expect = 2e-32
Identities = 106/316 (33%), Positives = 169/316 (52%), Gaps = 38/316 (12%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
++ IG G+ G V K ++ +A K I +E E + +E++++ I
Sbjct: 17 QIELIGRGSFGDVYKAFDKDLNKEVAIKVIDLEESEDEIEDIQKEISVLSQCRC-PYITE 75
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+YG++ + + ++ I+MEYM GS+ +L +S+ SI+C I+
Sbjct: 76 YYGSYLHQT---KLWIIMEYMAGGSVADLL---QSNNPLDETSIAC------------IT 117
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTST 345
+L+ + YL++ KI HRDIK +NIL++ GDVK+ DFGVS L +++ TFVGT
Sbjct: 118 RDLLHAVEYLHNEGKI-HRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPF 176
Query: 346 YMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPK 404
+M+PE IQ Y K D+WSLG+ +IE++ GE PL H P +L ++ R E P+
Sbjct: 177 WMAPEVIQNSEGYNEKADIWSLGITVIEMAKGEPPLADLH--PMRVLFIIPR---ETPPQ 231
Query: 405 LSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKK 464
L +EH+S ++ +FV+ C K R S KELI H FI + + R ++ K
Sbjct: 232 L--DEHFSRQVKEFVSLCLKKAPAERPSAKELIKHRFIKNARKSPKLLERIR---ERPKY 286
Query: 465 RIKEDKMIRREETERS 480
++KED EET R+
Sbjct: 287 QVKED-----EETPRN 297
>7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 492
Score = 137 bits (346), Expect = 3e-32
Identities = 108/367 (29%), Positives = 178/367 (48%), Gaps = 48/367 (13%)
Query: 119 PTTRDAPMSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQ----LENLVRLSKIGA 174
PT P+S T + ++ ++T +L++ NG Q + +L L +G
Sbjct: 159 PTPPHPPVSETDMKLKIIMEQT----------GKLNI---NGRQYPTDINDLKHLGDLGN 205
Query: 175 GNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD--NIVGFYGAF 232
G SG VVK +H+ + IIA K + +++ +L ++ + +HD IV G F
Sbjct: 206 GTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVV--LKSHDCKYIVKCLGCF 263
Query: 233 YNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLN 292
++ I ME M S C K + +S K E L +++ +N
Sbjct: 264 VRDP---DVWICMELM-------------SMCFDKLLKLSKKP--VPEQILGKVTVATVN 305
Query: 293 GLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT-FVGTSTYMSPER 351
L YL D + +IHRD+KPSNILI+ +G++K+CDFG+S L++S A+T G + YM+PER
Sbjct: 306 ALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPER 365
Query: 352 I--QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE 409
I + +Y + DVWSLG+ ++EL++ P G + ++L ++++ P L E
Sbjct: 366 IDPKKPKYDIRADVWSLGITLVELATARSPYEGCNTD----FEVLTKVLDSEPPCLPYGE 421
Query: 410 HY--SIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRIK 467
Y S + DFV +C K + R EL+ FI Y + + K + R
Sbjct: 422 GYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAKVDVPNWFQSIKDNRLRAN 481
Query: 468 EDKMIRR 474
D ++R
Sbjct: 482 GDPTLQR 488
>CE29622 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4
Length = 371
Score = 135 bits (341), Expect = 1e-31
Identities = 100/296 (33%), Positives = 150/296 (49%), Gaps = 28/296 (9%)
Query: 153 LSLTPENGI---QLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENK---EVLK 206
L L P + I + ++L L +G G+ G V K LH P + +A K I + N +
Sbjct: 55 LVLPPNDRIHEFERDHLQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINNGPDDAFN 114
Query: 207 NQLVR---ELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSD 263
+ R E+ K S D IV +YG +N + ME MD SLDK+ + D
Sbjct: 115 KSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVA---WMCMELMDL-SLDKLYMIAH-D 169
Query: 264 CHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKI 323
+ + E L ++ + L +L + IIHRDIKPSNIL++ G VK+
Sbjct: 170 IQKVEIP---------EQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKL 220
Query: 324 CDFGVSTTLINSLADTF-VGTSTYMSPERI--QGGRYTTKGDVWSLGLMIIELSSGEFPL 380
CDFG+ L NS+A + VG YM+PER+ G Y K +VWSLG+ ++E+++G++P
Sbjct: 221 CDFGICGYLQNSVAQSVDVGCRPYMAPERLAPNGDGYDIKSEVWSLGITMVEVANGKYPY 280
Query: 381 GGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKEL 436
G D P ILD ++ +V P L + S+ M F+ C IK+ R+S +L
Sbjct: 281 DGFMDAP--ILDQVRMVVYGDPPILDSDHEVSMSMKRFIALCTIKDRNLRASFDDL 334
>Hs15011880 [T] KOG0201 Serine/threonine protein kinase
Length = 416
Score = 131 bits (330), Expect = 2e-30
Identities = 93/301 (30%), Positives = 155/301 (50%), Gaps = 34/301 (11%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD 223
E +L +IG G+ G V K + +++A K I +E E + +E+T++ +
Sbjct: 22 ELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS-S 80
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
+ +YG++ S ++ I+MEY+ GS +L + F+E +
Sbjct: 81 YVTKYYGSYLKGS---KLWIIMEYLGGGSALDLL----------------RAGPFDEFQI 121
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFV 341
+ + +L GL YL+ K IHRDIK +N+L++ +GDVK+ DFGV+ L ++ +TFV
Sbjct: 122 ATMLKEILKGLDYLHS-EKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 180
Query: 342 GTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
GT +M+PE IQ Y +K D+WSLG+ IEL+ GE P H P +L L+ + N P
Sbjct: 181 GTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMH--PMRVLFLIPK--NNP 236
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE----FRH 457
+ ++ +F++ C K+ R + KEL+ H FI K + + + E F+
Sbjct: 237 PTLVG---DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKR 293
Query: 458 W 458
W
Sbjct: 294 W 294
>At1g53165 [T] KOG0201 Serine/threonine protein kinase
Length = 1007
Score = 131 bits (330), Expect = 2e-30
Identities = 100/304 (32%), Positives = 160/304 (51%), Gaps = 33/304 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG G+ G V K ++ +A K I +E E + +E++++ I +YG+
Sbjct: 348 IGRGSFGDVYKAFDTELNKDVAIKVIDLEESEDEIEDIQKEISVLSQCRC-PYITEYYGS 406
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVL 291
+ + + ++ I+MEYM GS+ +L +SI+C I+ +L
Sbjct: 407 YLHQT---KLWIIMEYMAGGSVADLLQPGNP---LDEISIAC------------ITRDLL 448
Query: 292 NGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTYMSP 349
+ + YL+ KI HRDIK +NIL++ GDVK+ DFGVS L +++ TFVGT +M+P
Sbjct: 449 HAVEYLHAEGKI-HRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAP 507
Query: 350 ERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN 408
E IQ Y K D+WSLG+ +IE++ GE PL H P +L ++ R E P+L +
Sbjct: 508 EVIQNSEGYNEKADIWSLGITMIEMAKGEPPLADLH--PMRVLFIIPR---ESPPQL--D 560
Query: 409 EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRIKE 468
EH+S + +FV+ C K R + KEL+ H FI + + R ++ K ++KE
Sbjct: 561 EHFSRPLKEFVSFCLKKAPAERPNAKELLKHRFIKNARKSPKLLERIR---ERPKYQVKE 617
Query: 469 DKMI 472
D+ I
Sbjct: 618 DEEI 621
>Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 419
Score = 130 bits (327), Expect = 5e-30
Identities = 100/364 (27%), Positives = 171/364 (46%), Gaps = 48/364 (13%)
Query: 119 PTTRDAPMSLTPTGVSMMQQET-DETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNS 177
P+T P S+ + QE +T LT R ++ +L L ++G+G
Sbjct: 78 PSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQA------EINDLENLGEMGSGTC 131
Query: 178 GTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD--NIVGFYGAFYNP 235
G V K +IA K + + +++ +L ++ + +HD IV +G F
Sbjct: 132 GQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV--LKSHDCPYIVQCFGTFI-- 187
Query: 236 STTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMP---LSRISFCVLN 292
T ++ I ME M C K K +P L +++ ++
Sbjct: 188 -TNTDVFIAMELM-------------GTCAEK-----LKKRMQGPIPERILGKMTVAIVK 228
Query: 293 GLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT-FVGTSTYMSPER 351
L YL + + +IHRD+KPSNIL++ +G +K+CDFG+S L++S A T G + YM+PER
Sbjct: 229 ALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPER 288
Query: 352 IQ-----GGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
I Y + DVWSLG+ ++EL++G+FP + + ++L +++ E P L
Sbjct: 289 IDPPDPTKPDYDIRADVWSLGISLVELATGQFP----YKNCKTDFEVLTKVLQEEPPLLP 344
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRI 466
+ +S + FV C K+ R R +L+ H FI +Y +T+ + W K V +
Sbjct: 345 GHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY---ETLEVDVASWFKDVMAKT 401
Query: 467 KEDK 470
+ +
Sbjct: 402 ESPR 405
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 129 bits (324), Expect = 1e-29
Identities = 93/276 (33%), Positives = 148/276 (52%), Gaps = 30/276 (10%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
+IG G+ G V K + +++A K I +E E + + +E+ ++ + + +YG
Sbjct: 18 RIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDS-PYVTKYYG 76
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
+F + ++ I+MEY+ GS ++ K F EM + I V
Sbjct: 77 SFLKGT---KLWIIMEYLGGGSALDLM----------------KAGSFEEMHIGIILREV 117
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTYMS 348
L GL YL+ K+ HRDIK +N+L++ +GDVK+ DFGV+ L N+ + +TFVGT +M+
Sbjct: 118 LKGLDYLHSERKL-HRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMA 176
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN 408
PE I+ +Y K D+WSLG+ IEL+ GE P H P +L L+ + N P P+L+ +
Sbjct: 177 PEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELH--PMRVLFLIPK--NNP-PQLTGS 231
Query: 409 EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
Y+ DFV C K+ R + KEL+ + FI K
Sbjct: 232 --YTKSFKDFVEACLNKDPENRPTAKELLKYPFIKK 265
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 129 bits (323), Expect = 1e-29
Identities = 93/319 (29%), Positives = 163/319 (50%), Gaps = 40/319 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV +++ A K + + E ++++ E+ ++K S H N+ +YGA
Sbjct: 27 VGNGTYGQVYKGRHVKTAQLAAIKIMNINEDE--EDEIKLEINMLKKHSHHRNVATYYGA 84
Query: 232 FYN--PSTT---NEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
F PS+T +++ ++ME+ GS+ +D + S K W ++ I
Sbjct: 85 FIKKLPSSTGKHDQLWLVMEFCGSGSI--------TDLVKNTKGGSLKEEW-----IAYI 131
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTS 344
+L GL +L+ K+IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT
Sbjct: 132 CREILRGLYHLHQS-KVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTP 190
Query: 345 TYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVN 399
+M+PE I Y ++ D+WSLG+ +E++ G PL H P L L+ R
Sbjct: 191 YWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMH--PMRALFLIPR--- 245
Query: 400 EPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWC 459
P PKL +N+ ++ + F+ +K+ R L+ H FI + + TI RH
Sbjct: 246 NPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTI----RH-- 299
Query: 460 KKVKKRIKEDKMIRREETE 478
+K+ I ++ +++++ +
Sbjct: 300 -SIKEHIDRNRRVKKDDAD 317
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 129 bits (323), Expect = 1e-29
Identities = 93/319 (29%), Positives = 163/319 (50%), Gaps = 40/319 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV +++ A K + + E ++++ E+ ++K S H N+ +YGA
Sbjct: 27 VGNGTYGQVYKGRHVKTAQLAAIKIMNINEDE--EDEIKLEINMLKKHSHHRNVATYYGA 84
Query: 232 FYN--PSTT---NEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
F PS+T +++ ++ME+ GS+ +D + S K W ++ I
Sbjct: 85 FIKKLPSSTGKHDQLWLVMEFCGSGSI--------TDLVKNTKGGSLKEEW-----IAYI 131
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTS 344
+L GL +L+ K+IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT
Sbjct: 132 CREILRGLYHLHQS-KVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTP 190
Query: 345 TYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVN 399
+M+PE I Y ++ D+WSLG+ +E++ G PL H P L L+ R
Sbjct: 191 YWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMH--PMRALFLIPR--- 245
Query: 400 EPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWC 459
P PKL +N+ ++ + F+ +K+ R L+ H FI + + TI RH
Sbjct: 246 NPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTI----RH-- 299
Query: 460 KKVKKRIKEDKMIRREETE 478
+K+ I ++ +++++ +
Sbjct: 300 -SIKEHIDRNRRVKKDDAD 317
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 129 bits (323), Expect = 1e-29
Identities = 93/319 (29%), Positives = 163/319 (50%), Gaps = 40/319 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV +++ A K + + E ++++ E+ ++K S H N+ +YGA
Sbjct: 27 VGNGTYGQVYKGRHVKTAQLAAIKIMNINEDE--EDEIKLEINMLKKHSHHRNVATYYGA 84
Query: 232 FYN--PSTT---NEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
F PS+T +++ ++ME+ GS+ +D + S K W ++ I
Sbjct: 85 FIKKLPSSTGKHDQLWLVMEFCGSGSI--------TDLVKNTKGGSLKEEW-----IAYI 131
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTS 344
+L GL +L+ K+IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT
Sbjct: 132 CREILRGLYHLHQS-KVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRRNTFIGTP 190
Query: 345 TYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVN 399
+M+PE I Y ++ D+WSLG+ +E++ G PL H P L L+ R
Sbjct: 191 YWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMH--PMRALFLIPR--- 245
Query: 400 EPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWC 459
P PKL +N+ ++ + F+ +K+ R L+ H FI + + TI RH
Sbjct: 246 NPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQTI----RH-- 299
Query: 460 KKVKKRIKEDKMIRREETE 478
+K+ I ++ +++++ +
Sbjct: 300 -SIKEHIDRNRRVKKDDAD 317
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 128 bits (322), Expect = 2e-29
Identities = 94/301 (31%), Positives = 152/301 (50%), Gaps = 34/301 (11%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD 223
E +L +IG G+ G V K + ++A K I +E E + +E+T++ +
Sbjct: 18 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS-P 76
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
I ++G++ + ++ I+MEY+ GS +L K E +
Sbjct: 77 YITRYFGSYLK---STKLWIIMEYLGGGSALDLL----------------KPGPLEETYI 117
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFV 341
+ I +L GL YL+ KI HRDIK +N+L++ +GDVK+ DFGV+ L ++ +TFV
Sbjct: 118 ATILREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 176
Query: 342 GTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
GT +M+PE I+ Y K D+WSLG+ IEL+ GE P H P +L L+ +
Sbjct: 177 GTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLH--PMRVLFLIPK----N 230
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE----FRH 457
+P + +H S +FV C K+ R R + KEL+ H FI +Y + + E ++
Sbjct: 231 SPPTLEGQH-SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKR 289
Query: 458 W 458
W
Sbjct: 290 W 290
>Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 462
Score = 128 bits (322), Expect = 2e-29
Identities = 90/320 (28%), Positives = 156/320 (48%), Gaps = 41/320 (12%)
Query: 162 QLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSA 221
++ +L L ++G+G G V K +IA K + + +++ +L ++ + +
Sbjct: 159 EINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVV--LKS 216
Query: 222 HD--NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFN 279
HD IV +G F T ++ I ME M C K K
Sbjct: 217 HDCPYIVQCFGTFI---TNTDVFIAMELM-------------GTCAEK-----LKKRMQG 255
Query: 280 EMP---LSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL 336
+P L +++ ++ L YL + + +IHRD+KPSNIL++ +G +K CDFG+S L++S
Sbjct: 256 PIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKFCDFGISGRLVDSK 315
Query: 337 ADT-FVGTSTYMSPERIQ-----GGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGI 390
A T G + YM+PERI Y + DVWSLG+ ++EL++G+FP + +
Sbjct: 316 AKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFP----YKNCKTD 371
Query: 391 LDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDT 450
++L +++ E P L + +S + FV C K+ R R +L+ H FI +Y +T
Sbjct: 372 FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY---ET 428
Query: 451 IAKEFRHWCKKVKKRIKEDK 470
+ + W K V + + +
Sbjct: 429 LEVDVASWFKDVMAKTESPR 448
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 128 bits (322), Expect = 2e-29
Identities = 94/301 (31%), Positives = 152/301 (50%), Gaps = 34/301 (11%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD 223
E +L +IG G+ G V K + ++A K I +E E + +E+T++ +
Sbjct: 18 ELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS-P 76
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
I ++G++ + ++ I+MEY+ GS +L K E +
Sbjct: 77 YITRYFGSYLK---STKLWIIMEYLGGGSALDLL----------------KPGPLEETYI 117
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFV 341
+ I +L GL YL+ KI HRDIK +N+L++ +GDVK+ DFGV+ L ++ +TFV
Sbjct: 118 ATILREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFV 176
Query: 342 GTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
GT +M+PE I+ Y K D+WSLG+ IEL+ GE P H P +L L+ +
Sbjct: 177 GTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLH--PMRVLFLIPK----N 230
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE----FRH 457
+P + +H S +FV C K+ R R + KEL+ H FI +Y + + E ++
Sbjct: 231 SPPTLEGQH-SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKR 289
Query: 458 W 458
W
Sbjct: 290 W 290
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 128 bits (322), Expect = 2e-29
Identities = 99/308 (32%), Positives = 154/308 (49%), Gaps = 30/308 (9%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD 223
E +L KIG G+ G V K + +++A K I +E E + +E+T++ +
Sbjct: 34 ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS-P 92
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
+ +YG++ + ++ I+MEY+ GS +L D E +
Sbjct: 93 YVTKYYGSYLKDT---KLWIIMEYLGGGSALDLLEPGPLD----------------ETQI 133
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFV 341
+ I +L GL YL+ K IHRDIK +N+L++ G+VK+ DFGV+ L ++ +TFV
Sbjct: 134 ATILREILKGLDYLHS-EKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFV 192
Query: 342 GTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
GT +M+PE I+ Y +K D+WSLG+ IEL+ GE P H P +L L+ + N P
Sbjct: 193 GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELH--PMKVLFLIPK--NNP 248
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKK 461
P L N YS + +FV C KE R + KEL+ H FI + + + E K+
Sbjct: 249 -PTLEGN--YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKR 305
Query: 462 VKKRIKED 469
K D
Sbjct: 306 WKAEQSHD 313
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 128 bits (322), Expect = 2e-29
Identities = 97/319 (30%), Positives = 159/319 (49%), Gaps = 38/319 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ ++G G G V K H R A K +E++E L + +V E+ I+ + H NIV
Sbjct: 40 VGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMV-EIDILSEIK-HPNIVEL 97
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
Y AF S +++ +L+EY D G+LD I+ ++ CK
Sbjct: 98 YEAF---SIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKH------------- 141
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
+ GL +L+ K+IHRD+K N+L+ +G VK+ DFGVS +++ DTF+GT +
Sbjct: 142 -MTEGLTFLHR-NKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKHDTFIGTPYW 199
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE + + Y K D+WSLG+ +IEL+ E P ++ + +L +I
Sbjct: 200 MAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPP-----NSEMSPMRVLLKIQKSE 254
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKK 461
PKL + +S E DF+ + +K+ + R + L+ H FI NR+ AK + +
Sbjct: 255 PPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFI----NRNLDAKPIKDLLLE 310
Query: 462 VKKRIKEDKMIRREETERS 480
K + E+ + +ETE S
Sbjct: 311 YKAEVVEE--VVDDETEVS 327
>At3g06230 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 293
Score = 127 bits (320), Expect = 3e-29
Identities = 98/288 (34%), Positives = 149/288 (51%), Gaps = 47/288 (16%)
Query: 151 ARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLV 210
A +S N + NL R+S +G+GN GTV K S I A K + KE + +
Sbjct: 38 ATVSSCASNTFSVANLDRISVLGSGNGGTVFKVKDKTTSEIYALKKV----KENWDSTSL 93
Query: 211 RELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVS 270
RE+ I++ V++ + + F NPS E+ ILM+YMD GSL+ + V
Sbjct: 94 REIEILRMVNS-PYVAKCHDIFQNPS--GEVSILMDYMDLGSLESLRGV----------- 139
Query: 271 ISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVST 330
E L+ +S VL G YL++ +KI+HRDIKP+N+L +SK +VKI DFGVS
Sbjct: 140 --------TEKQLALMSRQVLEGKNYLHE-HKIVHRDIKPANLLRSSKEEVKIADFGVSK 190
Query: 331 TLINSL--ADTFVGTSTYMSPERI---------QGGRYTTKGDVWSLGLMIIELSSGEFP 379
++ SL ++FVGT YMSPER+ + GD+WS GL ++E+ G +P
Sbjct: 191 IVVRSLNKCNSFVGTFAYMSPERLDSEADGVTEEDKSNVYAGDIWSFGLTMLEILVGYYP 250
Query: 380 LGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEE 427
+ P+ + EP PK E S ++ F++ CC++++
Sbjct: 251 M-----LPDQAAIVCAVCFGEP-PKAP--EECSDDLKSFMD-CCLRKK 289
>HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1165
Score = 127 bits (319), Expect = 4e-29
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 36/346 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV ++ A K + V E + ++ E+ ++K S H NI +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYGA 88
Query: 232 FYN---PSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
F P +++ ++ME+ GS+ +D + + K W ++ IS
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSI--------TDLVKNTKGNTLKEDW-----IAYISR 135
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
+L GL +L+ + +IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT +
Sbjct: 136 EILRGLAHLH-IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 194
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE I Y + D+WS G+ IE++ G PL H P L L+ R P
Sbjct: 195 MAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH--PMRALFLIPR---NP 249
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFR-HWCK 460
P+L K++ +S + F+ C +K R S ++L+ H FI N + + + H +
Sbjct: 250 PPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 461 KVKKRIKEDKM---IRREETERSKIEKRQLEKAALAVTAARSSSTR 503
KKR ++D+ E E ++ +++ E +++ S+ R
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRR 354
>Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1212
Score = 127 bits (319), Expect = 4e-29
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 36/346 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV ++ A K + V E + ++ E+ ++K S H NI +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYGA 88
Query: 232 FYN---PSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
F P +++ ++ME+ GS+ +D + + K W ++ IS
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSI--------TDLVKNTKGNTLKEDW-----IAYISR 135
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
+L GL +L+ + +IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT +
Sbjct: 136 EILRGLAHLH-IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 194
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE I Y + D+WS G+ IE++ G PL H P L L+ R P
Sbjct: 195 MAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH--PMRALFLIPR---NP 249
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFR-HWCK 460
P+L K++ +S + F+ C +K R S ++L+ H FI N + + + H +
Sbjct: 250 PPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 461 KVKKRIKEDKM---IRREETERSKIEKRQLEKAALAVTAARSSSTR 503
KKR ++D+ E E ++ +++ E +++ S+ R
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRR 354
>Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1320
Score = 127 bits (319), Expect = 4e-29
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 36/346 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV ++ A K + V E + ++ E+ ++K S H NI +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYGA 88
Query: 232 FYN---PSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
F P +++ ++ME+ GS+ +D + + K W ++ IS
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSI--------TDLVKNTKGNTLKEDW-----IAYISR 135
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
+L GL +L+ + +IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT +
Sbjct: 136 EILRGLAHLH-IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 194
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE I Y + D+WS G+ IE++ G PL H P L L+ R P
Sbjct: 195 MAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH--PMRALFLIPR---NP 249
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFR-HWCK 460
P+L K++ +S + F+ C +K R S ++L+ H FI N + + + H +
Sbjct: 250 PPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 461 KVKKRIKEDKM---IRREETERSKIEKRQLEKAALAVTAARSSSTR 503
KKR ++D+ E E ++ +++ E +++ S+ R
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRR 354
>Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1166
Score = 127 bits (319), Expect = 4e-29
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 36/346 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV ++ A K + V E + ++ E+ ++K S H NI +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKLEINMLKKYSHHRNIATYYGA 88
Query: 232 FYN---PSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
F P +++ ++ME+ GS+ +D + + K W ++ IS
Sbjct: 89 FIKKSPPGHDDQLWLVMEFCGAGSI--------TDLVKNTKGNTLKEDW-----IAYISR 135
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
+L GL +L+ + +IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT +
Sbjct: 136 EILRGLAHLH-IHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 194
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE I Y + D+WS G+ IE++ G PL H P L L+ R P
Sbjct: 195 MAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMH--PMRALFLIPR---NP 249
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFR-HWCK 460
P+L K++ +S + F+ C +K R S ++L+ H FI N + + + H +
Sbjct: 250 PPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDR 308
Query: 461 KVKKRIKEDKM---IRREETERSKIEKRQLEKAALAVTAARSSSTR 503
KKR ++D+ E E ++ +++ E +++ S+ R
Sbjct: 309 TRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRR 354
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 127 bits (318), Expect = 5e-29
Identities = 90/293 (30%), Positives = 150/293 (50%), Gaps = 30/293 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTI-PVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
IG G G V K L+ + + A K + P+ + + ++ E I+K +S H N+V FYG
Sbjct: 27 IGKGTYGKVFKVLNKKNGQKAAVKILDPIHD---IDEEIEAEYNILKALSDHPNVVRFYG 83
Query: 231 AFYNPSTTN--EIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
++ N ++ +++E GS+ ++ + R +E ++ I
Sbjct: 84 IYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGER-----------MSEPLIAYILH 132
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL--ADTFVGTSTY 346
L GL +L++ K IHRD+K +NIL+ ++G VK+ DFGVS L ++ +T VGT +
Sbjct: 133 EALMGLQHLHN-NKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFW 191
Query: 347 MSPERIQGGR-----YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE I + Y + D WSLG+ IEL G+ PL H + L +I P
Sbjct: 192 MAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHP-----MRALFKIPRNP 246
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
PKL + E +S E DF+++C K+ R ++ EL+ H FI + +D + ++
Sbjct: 247 PPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQK 299
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 127 bits (318), Expect = 5e-29
Identities = 90/293 (30%), Positives = 150/293 (50%), Gaps = 30/293 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTI-PVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
IG G G V K L+ + + A K + P+ + + ++ E I+K +S H N+V FYG
Sbjct: 27 IGKGTYGKVFKVLNKKNGQKAAVKILDPIHD---IDEEIEAEYNILKALSDHPNVVRFYG 83
Query: 231 AFYNPSTTN--EIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
++ N ++ +++E GS+ ++ + R +E ++ I
Sbjct: 84 IYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGER-----------MSEPLIAYILH 132
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL--ADTFVGTSTY 346
L GL +L++ K IHRD+K +NIL+ ++G VK+ DFGVS L ++ +T VGT +
Sbjct: 133 EALMGLQHLHN-NKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFW 191
Query: 347 MSPERIQGGR-----YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE I + Y + D WSLG+ IEL G+ PL H + L +I P
Sbjct: 192 MAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHP-----MRALFKIPRNP 246
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
PKL + E +S E DF+++C K+ R ++ EL+ H FI + +D + ++
Sbjct: 247 PPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQK 299
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 126 bits (317), Expect = 7e-29
Identities = 99/277 (35%), Positives = 144/277 (51%), Gaps = 31/277 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L K+G+G+ G V K IIA K I +E + +E+ ++ N ++ N++ +
Sbjct: 12 LRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNS-SNVIQY 70
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG F + T + ILME+MD GS+ +L + R NE +S I
Sbjct: 71 YGCFVDGYT---LWILMEHMDGGSVSGLLKMGR----------------LNEQVISIILR 111
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSK-GDVKICDFGVSTTLINSLA--DTFVGTST 345
VL GL YL+ KI HRDIK +NIL++S G+VK+ DFGV+ L N+ + TFVGT
Sbjct: 112 EVLYGLNYLHGQNKI-HRDIKAANILLSSSTGNVKLADFGVAAQLSNAASRRHTFVGTPF 170
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
+M+PE IQ Y D+WSLG+ IE+++G P H + ++ I PKL
Sbjct: 171 WMAPEVIQQTSYGLAADIWSLGITAIEMANGIPPRATMHP-----MRVIFEIPQSEPPKL 225
Query: 406 SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
++H+S DFV+ C R S KEL+ H FI
Sbjct: 226 --DDHFSPTFRDFVSCCLDLNPNMRWSAKELLQHPFI 260
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 126 bits (317), Expect = 7e-29
Identities = 98/322 (30%), Positives = 160/322 (49%), Gaps = 38/322 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ ++G G G V K + S + A K I +++E L++ +V E+ I+ + H NIV
Sbjct: 37 IGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-EIDILASCD-HPNIVKL 94
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
AFY N + IL+E+ G++D ++ + + CK +
Sbjct: 95 LDAFYYE---NNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQT------------ 139
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL--ADTFVGTSTY 346
L+ L YL+D KIIHRD+K NIL GD+K+ DFGVS ++ D+F+GT +
Sbjct: 140 --LDALNYLHD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYW 196
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE + + Y K DVWSLG+ +IE++ E P HH+ + +L +I
Sbjct: 197 MAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPP---HHEL--NPMRVLLKIAKSE 251
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNN---RDTIAKEFRHW 458
P L++ +S DF+ +C K R + +L+ H F+ +N R+ IA+
Sbjct: 252 PPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEV 311
Query: 459 CKKVKKRIKEDKMIRREETERS 480
++V+ +ED+ EETE S
Sbjct: 312 TEEVEDGKEEDE---EEETENS 330
>Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1295
Score = 126 bits (317), Expect = 7e-29
Identities = 92/318 (28%), Positives = 159/318 (49%), Gaps = 39/318 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K HV ++ A K + V E + ++ +E+ ++K S H NI +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE--EEEIKQEINMLKKYSHHRNIATYYGA 88
Query: 232 FYN---PSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKN-VSISCKTSWFNEMPLSRIS 287
F P +++ ++ME+ GS+ ++ + + +++ ++ C+
Sbjct: 89 FIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICRE------------ 136
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTST 345
+L GL +L+ +K+IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT
Sbjct: 137 --ILRGLAHLH-AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
Query: 346 YMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
+M+PE I Y + D+WSLG+ IE++ G PL H P L L+ R
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMH--PMRALFLIPR---N 248
Query: 401 PAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCK 460
P P+L K++ +S + DF++ C IK R ++L+ FI + + +
Sbjct: 249 PPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHID 307
Query: 461 KVKKRIKEDKMIRREETE 478
+ +K+ E +EETE
Sbjct: 308 RSRKKRGE-----KEETE 320
>At1g32320 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 305
Score = 125 bits (315), Expect = 1e-28
Identities = 96/286 (33%), Positives = 139/286 (48%), Gaps = 34/286 (11%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAH 222
L +L +LS +G G+ GTV KT H + A K + + L + E I+K + +
Sbjct: 45 LNDLEKLSVLGQGSGGTVYKTRHRRTKTLYALKVL----RPNLNTTVTVEADILKRIES- 99
Query: 223 DNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMP 282
I+ Y F + ++ +ME M+ GSL L + F+E
Sbjct: 100 SFIIKCYAVFVS---LYDLCFVMELMEKGSLHDALLAQQV---------------FSEPM 141
Query: 283 LSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVG 342
+S ++ +L GL YL I+H DIKPSN+LIN KG+VKI DFG S + + G
Sbjct: 142 VSSLANRILQGLRYLQKM-GIVHGDIKPSNLLINKKGEVKIADFGASRIVAGGDYGS-NG 199
Query: 343 TSTYMSPERIQ------GGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQR 396
T YMSPER+ GG GDVWSLG++++E G +PL D P+
Sbjct: 200 TCAYMSPERVDLEKWGFGGEVGFAGDVWSLGVVVLECYIGRYPLTKVGDKPDWATLFCAI 259
Query: 397 IVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
NE K+ S+E DFV RC K+ R R +++EL+ H F+
Sbjct: 260 CCNE---KVDIPVSCSLEFRDFVGRCLEKDWRKRDTVEELLRHSFV 302
>Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 681
Score = 123 bits (309), Expect = 6e-28
Identities = 117/443 (26%), Positives = 192/443 (42%), Gaps = 53/443 (11%)
Query: 25 EGSCNSLFKPKTLKRKNLKHLTLEXXXXX--XXXXPDEIPKGFSNG--------NGPTLS 74
EGS + + +LKR+ + + L P P+ N N P+L
Sbjct: 244 EGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLV 303
Query: 75 LMLEKLPVREEISPIS----RDTSFQTVSFLQXXXXXXXXXXXXXXXXPTTRDAPMSLT- 129
+ LP + + S DTS S P T A +S +
Sbjct: 304 AKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSN 363
Query: 130 ------PTGVSMMQQETDETATLTTQI--ARLSLTPENGIQLENLVRLSKIGAGNSGTVV 181
PT V+ ++T +T + A L + + G L KIG G++G V
Sbjct: 364 LYLPQDPT-VAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422
Query: 182 KTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEI 241
R +A K + + K+ + L E+ IM++ H N+V Y ++ E+
Sbjct: 423 LAREKHSGRQVAVKMMDLR-KQQRRELLFNEVVIMRDYQ-HFNVVEMYKSYL---VGEEL 477
Query: 242 VILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCY 301
+LME++ G+L I+S R NE ++ + VL L YL+
Sbjct: 478 WVLMEFLQGGALTDIVSQVR----------------LNEEQIATVCEAVLQALAYLH-AQ 520
Query: 302 KIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVGTSTYMSPERIQGGRYTT 359
+IHRDIK +IL+ G VK+ DFG + + + VGT +M+PE I Y T
Sbjct: 521 GVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT 580
Query: 360 KGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFV 419
+ D+WSLG+M+IE+ GE P D+P + ++R+ + P PKL + S + DF+
Sbjct: 581 EVDIWSLGIMVIEMVDGEPPY--FSDSP---VQAMKRLRDSPPPKLKNSHKVSPVLRDFL 635
Query: 420 NRCCIKEERGRSSLKELICHDFI 442
R +++ + R++ +EL+ H F+
Sbjct: 636 ERMLVRDPQERATAQELLDHPFL 658
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 123 bits (308), Expect = 7e-28
Identities = 89/277 (32%), Positives = 136/277 (48%), Gaps = 28/277 (10%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
R KIG G SGTV V + +A K I ++ K+ K ++ E+ +MK + + NIV
Sbjct: 251 RYEKIGQGASGTVFTATDVALGQEVAIKQINLQ-KQPKKELIINEILVMKELK-NPNIVN 308
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
F ++ +E+ ++MEY+ GSL +++ +T+ +E ++ +
Sbjct: 309 FLDSYL---VGDELFVVMEYLAGGSLTDVVT---------------ETACMDEAQIAAVC 350
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADTFVGTST 345
L L +L+ ++IHRDIK N+L+ +G VK+ DFG + S T VGT
Sbjct: 351 RECLQALEFLH-ANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPY 409
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
+M+PE + Y K D+WSLG+M IE+ GE P E L L I P+L
Sbjct: 410 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPY-----LNENPLRALYLIATNGTPEL 464
Query: 406 SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
E S DF+NRC + R S KEL+ H F+
Sbjct: 465 QNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL 501
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 122 bits (306), Expect = 1e-27
Identities = 102/365 (27%), Positives = 166/365 (44%), Gaps = 37/365 (10%)
Query: 81 PVREEISPISRDTSFQTVSFLQXXXXXXXXXXXXXXXXPTTRDAPMSLTPTGVSMMQQET 140
P + + SPI T Q PT++ P + +++
Sbjct: 541 PTKSKTSPI-----ISTAHTPQQVAQSPKAPAQETVTTPTSK--PAQARSLSKELNEKKR 593
Query: 141 DETATLTTQI-ARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPV 199
+E Q+ A+L+ +G L KIG G SG V + + +A K + +
Sbjct: 594 EERERRKKQLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNL 653
Query: 200 ENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSV 259
E K+ K ++ E+ +MK S H NIV F ++ ++ ++MEYM+ GSL +++
Sbjct: 654 E-KQPKKELIINEILVMKG-SKHPNIVNFIDSYV---LKGDLWVIMEYMEGGSLTDVVT- 707
Query: 260 YRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKG 319
E + + L+GL +L+ ++HRDIK NIL++ +G
Sbjct: 708 ---------------HCILTEGQIGAVCRETLSGLEFLHS-KGVLHRDIKSDNILLSMEG 751
Query: 320 DVKICDFGVSTTL--INSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGE 377
D+K+ DFG + +N T VGT +M+PE + Y K D+WSLG+MIIE+ GE
Sbjct: 752 DIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGE 811
Query: 378 FPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELI 437
P ++TP L L I PKL + E+ S + F++ C E R+S EL+
Sbjct: 812 PPY--LNETP---LRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELL 866
Query: 438 CHDFI 442
++I
Sbjct: 867 HDEYI 871
>CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 435
Score = 122 bits (305), Expect = 2e-27
Identities = 94/296 (31%), Positives = 150/296 (49%), Gaps = 29/296 (9%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+S +G+G+ G VV++ V + K +NKE LK +++R++ IM ++ IV
Sbjct: 125 ISLLGSGSCG-VVESATVRSKLMAVKTMYKNDNKENLK-RILRDVRIMSMCNS-PFIVTS 181
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG F S+ + I M+ M + +Y S K +F E I +
Sbjct: 182 YGYFMFDSS---VKICMQIMSACCEKLLRRIYHS-----------KLDFFPEFVAGHIVY 227
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT-FVGTSTYM 347
++ L YL + + IIHRDIKPSNIL + G+VK+CDFG+S + +S+A + G YM
Sbjct: 228 SAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYM 287
Query: 348 SPERI---QGGRYTTKGDVWSLGLMIIELSSG--EFPLGGHHDTPEGILDLLQRIVNEPA 402
+PER+ +Y + DVWSLG+ + +L +G FPL T I+ L N P+
Sbjct: 288 APERLTIETNSKYDVRSDVWSLGITVYQLVTGLYPFPLNDMEFTTLTIIANL----NLPS 343
Query: 403 PKLSK--NEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFR 456
P L + +S +F++ C K+ R R ++L+ HDF Y+ A +F+
Sbjct: 344 PSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFYLDYDPASGSAYKFK 399
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 121 bits (304), Expect = 2e-27
Identities = 107/345 (31%), Positives = 163/345 (47%), Gaps = 42/345 (12%)
Query: 119 PTTRDAPMSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSG 178
P DA ++ P GV+ ++ T + +++L N + + K G G SG
Sbjct: 500 PKRPDADVA-QPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASG 558
Query: 179 TV--VKTLHVP-------------DSRIIAKKTI---PVENKEVLKNQLVRELTIMKNVS 220
+V + H+P D + K V +K+ K +V E+ +MK+ S
Sbjct: 559 SVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKD-S 617
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKIL--SVYRSDCHRKNVSISCKTSWF 278
H NIV F A+ T +++ ++ME+M+ GSL I+ S + H S
Sbjct: 618 RHKNIVNFLEAYLR--TDDDLWVVMEFMEGGSLTDIIENSPTNDNSH----------SPL 665
Query: 279 NEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SL 336
E ++ I GL +L+D + IIHRDIK N+L++++ VKI DFG L + S
Sbjct: 666 TEPQIAYIVRETCQGLKFLHDKH-IIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSK 724
Query: 337 ADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQR 396
T VGT +M+PE ++ Y K DVWSLG+M IE+ GE P E L L
Sbjct: 725 RATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPY-----LNEDPLKALYL 779
Query: 397 IVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDF 441
I PKL E S+E+ F++ C + R R+S +EL+ H F
Sbjct: 780 IATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGF 824
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 121 bits (304), Expect = 2e-27
Identities = 104/338 (30%), Positives = 169/338 (49%), Gaps = 40/338 (11%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--KEVLKNQLVRELTIMKNVSAHDNIVGF 228
+IG G G V K L + + +A K + +EN +E L N +++E+ ++KN++ H NIV +
Sbjct: 25 EIGKGAYGRVYKGLDLENGDFVAIKQVSLENIVQEDL-NTIMQEIDLLKNLN-HKNIVKY 82
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
G+ T + I++EY++ GSL I+ K + F P S ++
Sbjct: 83 LGS---SKTKTHLHIILEYVENGSLANII----------------KPNKFGPFPESLVAV 123
Query: 289 C---VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT--FVGT 343
VL GL+YL++ +IHRDIK +NIL +G VK+ DFGV+T L + +T VGT
Sbjct: 124 YIAQVLEGLVYLHE-QGVIHRDIKGANILTTKEGLVKLADFGVATKLNEADVNTHSVVGT 182
Query: 344 STYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
+M+PE I+ D+WS+G +IEL + P ++D + L RIV + P
Sbjct: 183 PYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPP---YYDLQP--MPALFRIVQDDNP 237
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVK 463
+ + S ++TDF+ +C K+ R R K L+ H +I N+R + RH
Sbjct: 238 PIP--DSLSPDITDFLRQCFKKDSRQRPDAKTLLSHPWI--RNSRRALQSSLRH--SGTI 291
Query: 464 KRIKEDKMIRREETERSKIEKRQLEKAALAVTAARSSS 501
K +KE ++ E S+ L + ++ S S
Sbjct: 292 KYMKEATASSEKDDEGSQDAAESLSGENVGISKTDSKS 329
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 121 bits (304), Expect = 2e-27
Identities = 92/307 (29%), Positives = 150/307 (47%), Gaps = 32/307 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V K H ++ A K + V E + ++ E+ ++K S H NI +YGA
Sbjct: 38 VGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDE--EEEIKLEINVLKKYSNHRNIATYYGA 95
Query: 232 FYN---PSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
F P +++ ++MEY GS+ +D + S K W ++ I
Sbjct: 96 FIKKSPPGKDDQLWLVMEYCGAGSV--------TDLVKSTKGQSLKEEW-----IAYICR 142
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
+L GL YL+ K+IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT +
Sbjct: 143 EILRGLSYLHS-NKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYW 201
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE I Y + D+WSLG+ +E++ + PL H P L L+ R N P
Sbjct: 202 MAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLH--PMRALFLIPR--NSP 257
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKK 461
P+L K++ +S + F++ +K+ R + L+ H FI + + + +
Sbjct: 258 -PRL-KSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDR 315
Query: 462 VKKRIKE 468
KKR +E
Sbjct: 316 CKKRKQE 322
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 120 bits (301), Expect = 5e-27
Identities = 94/317 (29%), Positives = 153/317 (47%), Gaps = 34/317 (10%)
Query: 128 LTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVP 187
+T T + ++ D+ + +I L PE + +IG G+ G V K +
Sbjct: 1 MTTTSSDELPRQADDDSMKWDRIYIQKLDPE-----VIFTKQERIGRGSFGEVYKGIDNR 55
Query: 188 DSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEY 247
R++A K I +E E + +E+ ++ + + ++G+F S ++ I+MEY
Sbjct: 56 TGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQ-YVTKYFGSFLKGS---KLWIIMEY 111
Query: 248 MDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRD 307
+ GS + K+ +E ++ I +L GL YL+ KI HRD
Sbjct: 112 LGGGSALDLT----------------KSGKLDESHIAVILREILKGLEYLHSERKI-HRD 154
Query: 308 IKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVGTSTYMSPERIQGGRYTTKGDVWS 365
IK +N+L++ GDVK+ DFGV+ L ++ TFVG+ +M+PE I+ Y K D+WS
Sbjct: 155 IKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWS 214
Query: 366 LGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIK 425
LG+ IEL++GE P H P +L L+ + P P L + +S +FV C K
Sbjct: 215 LGITAIELANGEPPHSDLH--PMRVLFLIPK---NPPPVL-QGSQWSKPFKEFVEMCLNK 268
Query: 426 EERGRSSLKELICHDFI 442
+ R S L+ H FI
Sbjct: 269 DPENRPSASTLLKHQFI 285
>YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 655
Score = 120 bits (300), Expect = 6e-27
Identities = 99/292 (33%), Positives = 143/292 (48%), Gaps = 33/292 (11%)
Query: 169 LSKIGAGNSGTVV--KTLHVPDS-----------RIIAKKTI--PVENKEVLKNQLVREL 213
+ K G G SG V K + +P R++ ++ + E K QL+
Sbjct: 363 VEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNE 422
Query: 214 TIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKIL-SVYRSDCHRKNVSIS 272
++ N S +NIV F A+ E+ ++MEYM+ G L IL +V RS+ +
Sbjct: 423 LLVMNDSRQENIVNFLEAYIIDD--EELWVIMEYMEGGCLTDILDAVARSNTGEHS---- 476
Query: 273 CKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFG--VST 330
S NE ++ I GL +L++ KIIHRDIK NIL+NS+G VKI DFG V
Sbjct: 477 ---SPLNENQMAYIVKETCQGLKFLHN-KKIIHRDIKSDNILLNSQGLVKITDFGFCVEL 532
Query: 331 TLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGI 390
T S T VGT +M+PE + Y K DVWSLG+M+IE+ GE P E
Sbjct: 533 TEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPY-----LNEDP 587
Query: 391 LDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
L L I N +PKL E S + F++ C R+S+++L+ +F+
Sbjct: 588 LKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFL 639
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 120 bits (300), Expect = 6e-27
Identities = 105/338 (31%), Positives = 170/338 (50%), Gaps = 42/338 (12%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--KEVLKNQLVRELTIMKNVSAHDNIVGF 228
+IG G G V L + + +A K + +EN +E L N +++E+ ++KN++ H NIV +
Sbjct: 25 EIGKGAYGRVYIGLDLENGDFVAIKQVSLENIGQEDL-NTIMQEIDLLKNLN-HKNIVKY 82
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
G+ T + I++EY++ GSL I+ K + F P S ++
Sbjct: 83 LGSL---KTKTHLHIILEYVENGSLANII----------------KPNKFGPFPESLVTV 123
Query: 289 C---VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT--FVGT 343
VL GL+YL++ +IHRDIK +NIL +G VK+ DFGV+T L + +T VGT
Sbjct: 124 YIAQVLEGLVYLHE-QGVIHRDIKGANILTTKEGLVKLADFGVATKLNEADFNTHSVVGT 182
Query: 344 STYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
+M+PE I+ D+WS+G IIEL + P ++D + L RIV + P
Sbjct: 183 PYWMAPEVIELSGVCAASDIWSVGCTIIELLTCVPP---YYDLQP--MPALYRIVQDDTP 237
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVK 463
+ + S ++TDF+ C K+ R R K L+ H +I N+R + RH
Sbjct: 238 PIP--DSLSPDITDFLRLCFKKDSRQRPDAKTLLSHPWI--RNSRRALRSSLRH--SGTI 291
Query: 464 KRIKEDKMIRREETERSK--IEKRQLEKAALAVTAARS 499
+ +KE ++ E S+ +E EK + T ++S
Sbjct: 292 RYMKETDSSSEKDAEGSQEVVESVSAEKVEVTKTNSKS 329
>SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase
Length = 312
Score = 119 bits (298), Expect = 1e-26
Identities = 88/279 (31%), Positives = 141/279 (49%), Gaps = 28/279 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L IG G+ G+V + V S+I+A K + ++ + L +E+ + ++++ +I +
Sbjct: 9 LQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSV-HITKY 67
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
Y +F + + I MEY D GS +L + + F+E ++ +
Sbjct: 68 YASFVDGF---RLWITMEYCDGGSCLDLLKL---------------SGTFSERVIAEVMR 109
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL--INSLADTFVGTSTY 346
VL L+YL+ K+ HRDIK +NIL G VK+ DFGVS L + D FVGT +
Sbjct: 110 QVLEALVYLHGQGKM-HRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFW 168
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
M+PE ++ Y K D+WSLG+ EL++GE P G H + +L I P L
Sbjct: 169 MAPEVVKQTGYNYKADIWSLGITAYELATGEPPYSGIHP-----MKVLLLIPKHSPPSLE 223
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKY 445
+++ +S DFV+ C K + R++ + L H FI KY
Sbjct: 224 RSK-FSRAFCDFVSNCLKKNPKDRATAEYLSKHKFIKKY 261
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 119 bits (298), Expect = 1e-26
Identities = 85/290 (29%), Positives = 146/290 (50%), Gaps = 29/290 (10%)
Query: 165 NLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDN 224
+L +IG G++G V + +I+A K + + K+ + L E++I++ H N
Sbjct: 248 DLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLR-KQQRRELLFNEVSILRQYQ-HPN 305
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
IV F+ + +E+ ++ME+M+ GSL I++ R E ++
Sbjct: 306 IVRFFSSHL---VDDELWVVMEFMEGGSLTDIVTATR----------------MTEPQIA 346
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVG 342
IS VL L +L+ K+IHRDIK +IL+ G VK+ DFG L + + VG
Sbjct: 347 TISRQVLGALDFLH-ARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVG 405
Query: 343 TSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
T + + E I Y T+ D+WS G+M+IE+ GE P +D P ++RI +E
Sbjct: 406 TPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPF--FNDQP---FQAMKRIRDEHE 460
Query: 403 PKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIA 452
+ S++ S+E+++ ++ C +K+ R K+L+ H F K + +IA
Sbjct: 461 ARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIA 510
>CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 542
Score = 119 bits (298), Expect = 1e-26
Identities = 85/290 (29%), Positives = 146/290 (50%), Gaps = 29/290 (10%)
Query: 165 NLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDN 224
+L +IG G++G V + +I+A K + + K+ + L E++I++ H N
Sbjct: 250 DLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLR-KQQRRELLFNEVSILRQYQ-HPN 307
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
IV F+ + +E+ ++ME+M+ GSL I++ R E ++
Sbjct: 308 IVRFFSSHL---VDDELWVVMEFMEGGSLTDIVTATR----------------MTEPQIA 348
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVG 342
IS VL L +L+ K+IHRDIK +IL+ G VK+ DFG L + + VG
Sbjct: 349 TISRQVLGALDFLH-ARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVG 407
Query: 343 TSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
T + + E I Y T+ D+WS G+M+IE+ GE P +D P ++RI +E
Sbjct: 408 TPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPF--FNDQP---FQAMKRIRDEHE 462
Query: 403 PKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIA 452
+ S++ S+E+++ ++ C +K+ R K+L+ H F K + +IA
Sbjct: 463 ARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIA 512
>SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 658
Score = 118 bits (296), Expect = 2e-26
Identities = 90/274 (32%), Positives = 138/274 (49%), Gaps = 29/274 (10%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
KIG G SG V V + +A K + + N++ K +V E+ +MK+ H NIV F
Sbjct: 391 KIGQGASGDVYSARQVGTNLSVAIKKMNI-NQQPKKEFIVNEILVMKS-HHHKNIVNFID 448
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
F+ S E+ ++MEYM GSL ++++ + ++ CK +
Sbjct: 449 TFFYKS---ELWMVMEYMRGGSLTEVVT--NNTLSEGQIAAICKET-------------- 489
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVGTSTYMS 348
L GL +L++ I+HRDIK NIL++ +GD+K+ DFG + +++ T VGT +M+
Sbjct: 490 LEGLQHLHE-NGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMA 548
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN 408
PE + Y K DVWSLG+M IE+ GE P E L L I PK+S+
Sbjct: 549 PEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPY-----LNENPLRALYLIATIGTPKISRP 603
Query: 409 EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
E S DF+++ + R S EL+ H F+
Sbjct: 604 ELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFL 637
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 118 bits (296), Expect = 2e-26
Identities = 87/274 (31%), Positives = 138/274 (49%), Gaps = 29/274 (10%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
+IG G+ G V K + R++A K I +E E + +E+ ++ + + ++G
Sbjct: 37 RIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQ-YVTKYFG 95
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
+F S ++ I+MEY+ GS + K+ +E ++ I +
Sbjct: 96 SFLKGS---KLWIIMEYLGGGSALDLT----------------KSGKLDESHIAVILREI 136
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVGTSTYMS 348
L GL YL+ KI HRDIK +N+L++ GDVK+ DFGV+ L ++ TFVG+ +M+
Sbjct: 137 LKGLEYLHSERKI-HRDIKAANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMA 195
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN 408
PE I+ Y K D+WSLG+ IEL++GE P H P +L L+ + P P L +
Sbjct: 196 PELIKQSSYDYKADIWSLGITAIELANGEPPHSDLH--PMRVLFLIPK---NPPPVL-QG 249
Query: 409 EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+S +FV C K+ R S L+ H FI
Sbjct: 250 SQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 283
>CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 505
Score = 118 bits (295), Expect = 2e-26
Identities = 97/390 (24%), Positives = 182/390 (45%), Gaps = 67/390 (17%)
Query: 134 SMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIA 193
++M+Q + + LT Q R L+ L + IG G+ GTV K + S I+A
Sbjct: 46 NLMKQAEENSGYLTLQGNRRKA------DLKELQFVEDIGHGSCGTVTKCRY--KSVIMA 97
Query: 194 KKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSL 253
KT+P + ++++ +L ++ IV +G F T ++ + ME M L
Sbjct: 98 VKTMPRTSNSYEMSRILMDLDVICLSFDCPYIVRCFGYFI---TNFDVRVCMECM-ATCL 153
Query: 254 DKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNI 313
D++L + E + ++S ++ L YL ++I+HRD+KPSNI
Sbjct: 154 DRLLIRIKQP--------------IPERIIGKLSVSIIKALHYLKTKHQIMHRDVKPSNI 199
Query: 314 LINSKGDVKICDFGVSTTLINSLADT-FVGTSTYMSPERIQGGR---YTTKGDVWSLGLM 369
L++ G +K+CDFG++ LI S A + G YM PER+ Y + DVWS G+
Sbjct: 200 LLDWSGVIKLCDFGIAGRLIESRAHSKQAGCPLYMGPERLDPNNFDSYDIRSDVWSFGVT 259
Query: 370 IIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERG 429
++EL++G++P G D++ +I+N+ P+L + +S + V C ++
Sbjct: 260 LVELATGQYPYAGTE------FDMMSKILNDEPPRLDPAK-FSPDFCQLVESCLQRDPTM 312
Query: 430 RSSLKELICHDFI---------------------CKYNNRDTIAKEFRHWCKKVKKRIK- 467
R + L+ H F+ Y+N + I+ + + ++++I+
Sbjct: 313 RPNYDMLLQHPFVVHHEKIETDVEEWFADVMGDDSAYHNSNEISNLTDQYAQSLQQQIQL 372
Query: 468 --------EDKMIRREETERSKIEKRQLEK 489
+++ ++REE E+ +I ++E+
Sbjct: 373 LQIENAFLKEQQVKREENEQERIRNIEMEE 402
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 118 bits (295), Expect = 2e-26
Identities = 89/284 (31%), Positives = 141/284 (49%), Gaps = 30/284 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTI-PVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
+ IG G G V K + D + A K + PV + + ++ E I++ + H N+V
Sbjct: 30 IETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMD---EEIEAEYNILQFLPNHPNVVK 86
Query: 228 FYGAFYNPS--TTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSR 285
FYG FY ++ +++E + GS+ +++ R +E +S
Sbjct: 87 FYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQR-----------LDEAMISY 135
Query: 286 ISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS--LADTFVGT 343
I + L GL +L++ +IIHRD+K +NIL+ ++G VK+ DFGVS L ++ +T VGT
Sbjct: 136 ILYGALLGLQHLHN-NRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGT 194
Query: 344 STYMSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
+M+PE I Y + DVWSLG+ IEL G+ PL H + L +I
Sbjct: 195 PFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHP-----VKTLFKIP 249
Query: 399 NEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P P L E + E F+++C IK+ R S+ L+ H FI
Sbjct: 250 RNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFI 293
>Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 544
Score = 117 bits (293), Expect = 4e-26
Identities = 96/331 (29%), Positives = 153/331 (46%), Gaps = 34/331 (10%)
Query: 119 PTTRDAPMSLTPTGVSMMQQETD---ETATLTTQ--IARLSLTPENGIQLENLVRLSKIG 173
P P S S + + TD + + +T + + +L G + R KIG
Sbjct: 216 PNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIG 275
Query: 174 AGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFY 233
G SGTV L + + +A K + ++ ++ K ++ E+ +M+ + + NIV + ++
Sbjct: 276 QGASGTVYTALDIATGQEVAIKQMNLQ-QQPKKELIINEILVMRE-NKNPNIVNYLDSYL 333
Query: 234 NPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNG 293
+E+ ++MEY+ GSL + V+ +C +E ++ + L
Sbjct: 334 ---VGDELWVVMEYLAGGSLTDV------------VTETC----MDEGQIAAVCRECLQA 374
Query: 294 LIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADTFVGTSTYMSPER 351
L +L+ ++IHRDIK NIL+ G VK+ DFG + S T VGT +M+PE
Sbjct: 375 LDFLHS-NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 433
Query: 352 IQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHY 411
+ Y K D+WSLG+M IE+ GE P E L L I P+L E
Sbjct: 434 VTRKAYGPKVDIWSLGIMAIEMVEGEPPY-----LNENPLRALYLIATNGTPELQNPERL 488
Query: 412 SIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
S DF+NRC + R S KEL+ H F+
Sbjct: 489 SAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519
>Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 545
Score = 117 bits (292), Expect = 5e-26
Identities = 87/277 (31%), Positives = 135/277 (48%), Gaps = 29/277 (10%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
R KIG G SGTV + V + +A K + ++ ++ K ++ E+ +M+ + + NIV
Sbjct: 272 RFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQ-QQPKKELIINEILVMRE-NKNPNIVN 329
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+ ++ +E+ ++MEY+ GSL + V+ +C +E ++ +
Sbjct: 330 YLDSYL---VGDELWVVMEYLAGGSLTDV------------VTETC----MDEGQIAAVC 370
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADTFVGTST 345
L L +L+ ++IHRDIK NIL+ G VK+ DFG + S T VGT
Sbjct: 371 RECLQALEFLHS-NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPY 429
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
+M+PE + Y K D+WSLG+M IE+ GE P E L L I P+L
Sbjct: 430 WMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPY-----LNENPLRALYLIATNGTPEL 484
Query: 406 SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
E S DF+NRC + R S KEL+ H F+
Sbjct: 485 QNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFL 521
>SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 589
Score = 116 bits (291), Expect = 7e-26
Identities = 93/298 (31%), Positives = 145/298 (48%), Gaps = 39/298 (13%)
Query: 154 SLTPENGIQLENLVRLSKIGAGNSGTVV-------KTLHVPDSRIIAKKTIPVENKEVLK 206
S+T + ++ N+ K+G G SG+V K L + DS +A K+I ++ + K
Sbjct: 299 SVTSHDPVEYFNVKH--KLGQGASGSVYLAKVVGGKQLGIFDS--VAIKSIDLQC-QTRK 353
Query: 207 NQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHR 266
++ E+T+M+ S H NIV + +F + ++MEYM+ GSL I+
Sbjct: 354 ELILNEITVMRE-SIHPNIVTYLDSFL--VRERHLWVVMEYMNAGSLTDII--------- 401
Query: 267 KNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDF 326
+ S E ++RI G+ +L+ IIHRDIK N+L+++ G++KI DF
Sbjct: 402 -------EKSKLTEAQIARICLETCKGIQHLH-ARNIIHRDIKSDNVLLDNSGNIKITDF 453
Query: 327 GVSTTLINSLAD--TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHH 384
G L N T VGT +M+PE ++ Y TK D+WSLG+MIIE+ E P
Sbjct: 454 GFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPY---- 509
Query: 385 DTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
E + L I P L K S + F+N C + R++ EL+ H F+
Sbjct: 510 -LREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIFRATAAELLTHSFL 566
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 114 bits (286), Expect = 3e-25
Identities = 86/276 (31%), Positives = 143/276 (51%), Gaps = 29/276 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG G+ G V K ++ +++A K + EN E L N ++ E++++KN++ H+NIV ++G
Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEVVYENDEEL-NDIMAEISLLKNLN-HNNIVKYHGF 88
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVL 291
+ E+ IL+EY GSL +++S R + +S E L
Sbjct: 89 IRK---SYELYILLEYCANGSLRRLIS-------RSSTGLS-------ENESKTYVTQTL 131
Query: 292 NGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSPER 351
GL YL+ +IHRDIK +NIL+++ VK+ DFGVS T++NS A T GT +M+PE
Sbjct: 132 LGLKYLHG-EGVIHRDIKAANILLSADNTVKLADFGVS-TIVNSSALTLAGTLNWMAPEI 189
Query: 352 IQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHY 411
+ +T D+WSLG ++E+ + P H+ T I ++ P S+
Sbjct: 190 LGNRGASTLSDIWSLGATVVEMLTKNPPY--HNLTDANIYYAVENDTYYPPSSFSE---- 243
Query: 412 SIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNN 447
+ DF+++C +K R + +L+ H +I N
Sbjct: 244 --PLKDFLSKCFVKNMYKRPTADQLLKHVWINSTEN 277
>Hs14771959 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 719
Score = 114 bits (286), Expect = 3e-25
Identities = 85/294 (28%), Positives = 144/294 (48%), Gaps = 29/294 (9%)
Query: 151 ARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLV 210
A L L G E L KIG G++G V + +A K + + K+ + L
Sbjct: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLR-KQQRRELLF 492
Query: 211 RELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVS 270
E+ IM++ HDN+V Y ++ +E+ ++ME+++ G+L I++ R
Sbjct: 493 NEVVIMRDYH-HDNVVDMYSSYL---VGDELWVVMEFLEGGALTDIVTHTR--------- 539
Query: 271 ISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVST 330
NE ++ + VL L YL++ +IHRDIK +IL+ S G +K+ DFG
Sbjct: 540 -------MNEEQIATVCLSVLRALSYLHN-QGVIHRDIKSDSILLTSDGRIKLSDFGFCA 591
Query: 331 TLINSLAD--TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPE 388
+ + + VGT +M+PE I Y T+ D+WSLG+M+IE+ GE P E
Sbjct: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFN-----E 646
Query: 389 GILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
L ++RI + P++ S + F++ ++E R++ +EL+ H F+
Sbjct: 647 PPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFL 700
>Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 833
Score = 112 bits (281), Expect = 1e-24
Identities = 87/280 (31%), Positives = 141/280 (50%), Gaps = 31/280 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L ++G G G V K ++A K + +E + + L +E+ I+K H NIV +
Sbjct: 20 LQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVST-LQKEILILKTCR-HANIVAY 77
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
+G++ ++ I ME+ GSL I V T +E+ +S +
Sbjct: 78 HGSYL---WLQKLWICMEFCGAGSLQDIYQV---------------TGSLSELQISYVCR 119
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVGTSTY 346
VL GL YL+ K IHRDIK +NILIN G+V++ DFG+S + +LA +F+GT +
Sbjct: 120 EVLQGLAYLHS-QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYW 178
Query: 347 MSPE----RIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
M+PE ++GG Y D+WSLG+ IEL+ + PL H P +L L+ + +P
Sbjct: 179 MAPEVAAVALKGG-YNELCDIWSLGITAIELAELQPPLFDVH--PLRVLFLMTKSGYQP- 234
Query: 403 PKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P+L + +S +F+ K + R S +++ H +
Sbjct: 235 PRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV 274
>Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 527
Score = 112 bits (281), Expect = 1e-24
Identities = 95/331 (28%), Positives = 155/331 (46%), Gaps = 37/331 (11%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG+G + V P +A K I +E + ++L++E+ M H NIV +Y +
Sbjct: 23 IGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCH-HPNIVSYYTS 81
Query: 232 FYNPSTTNEIVILMEYMDCGS-LDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
F +E+ ++M+ + GS LD I + H+ V +E ++ I V
Sbjct: 82 FV---VKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGV--------LDESTIATILREV 130
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI-------NSLADTFVGT 343
L GL YL+ +I HRD+K NIL+ G V+I DFGVS L N + TFVGT
Sbjct: 131 LEGLEYLHKNGQI-HRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 189
Query: 344 STYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
+M+PE ++ R Y K D+WS G+ IEL++G P +H P + L+ + N+P
Sbjct: 190 PCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAP---YHKYPP-MKVLMLTLQNDP- 244
Query: 403 PKLSKN-------EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEF 455
P L + Y ++ C K+ R + EL+ H F K N++ + ++
Sbjct: 245 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKT 304
Query: 456 RHWCKKVKKRIKEDKMIRREETERSKIEKRQ 486
+ +R K+ +RR ++ K +
Sbjct: 305 LQRAPTISERAKK---VRRVPGSSGRLHKTE 332
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 112 bits (281), Expect = 1e-24
Identities = 82/273 (30%), Positives = 138/273 (50%), Gaps = 26/273 (9%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
++G G SG V + + +A KTI ++N+ K+ ++ E+ ++K+ + H N+V F
Sbjct: 298 EVGKGASGIVFIAADLQNESQVAVKTIDMKNQSS-KDLILTEIRVLKDFN-HKNLVNFLD 355
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
A Y +++ ++MEYMD G L +++ + + ++ C+ + L ISF
Sbjct: 356 A-YLLEPEDQLWVVMEYMDGGPLTDVVT--ETVMKERQIACVCRET------LYAISFLH 406
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI-NSLADTFVGTSTYMSP 349
G IIHRDIK N+L+ G VK+ DFG + + T VGT +M+P
Sbjct: 407 AKG---------IIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAP 457
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE 409
E + +Y K D+WS+G+M IE+ G+ P ++TP L L I P + +
Sbjct: 458 EVVTRKKYGKKVDIWSIGIMAIEMIEGQPPY--LYETP---LRALYLIAANGRPDIKSWD 512
Query: 410 HYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
S + DF++RC E R++ EL+ H F+
Sbjct: 513 KLSPNLQDFLDRCLQVEVDRRATADELLSHPFL 545
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 112 bits (279), Expect = 2e-24
Identities = 97/331 (29%), Positives = 165/331 (49%), Gaps = 41/331 (12%)
Query: 159 NGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLV---RELTI 215
+ IQ ++ +G G G V + L++ + +A K + + ++LK+ L E+ +
Sbjct: 2 HNIQASSITLGDCLGKGAFGAVYRGLNIKNGETVAVKKVKLS--KMLKSDLSVIKMEIDL 59
Query: 216 MKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKT 275
+KN+ H NIV + G++ T + + I++EY + GSL I CK
Sbjct: 60 LKNLD-HPNIVKYRGSY---QTNDSLCIILEYCENGSLRSI----------------CKN 99
Query: 276 SWFNEMPLSRIS---FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL 332
F ++P + ++ F VL GL+YL++ +IHRDIK +NIL G +K+ DFGV+T
Sbjct: 100 --FGKIPENLVALYTFQVLQGLLYLHN-QGVIHRDIKGANILTTKDGTIKLADFGVATK- 155
Query: 333 INSLAD-TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGIL 391
IN+L D + VG+ +M+PE I+ TT D+WS+G +IEL G P ++D
Sbjct: 156 INALEDHSVVGSPYWMAPEVIELVGATTASDIWSVGCTVIELLDGNPP---YYDLDP--T 210
Query: 392 DLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTI 451
L R+V + P L N S F+ +C K+ R ++L+ H ++ N +
Sbjct: 211 SALFRMVKDEHPPLPSN--ISSAAKSFLMQCFQKDPNLRIKTRKLLKHPWVI-MNQTSSK 267
Query: 452 AKEFRHWCKKVKKRIKEDKMIRREETERSKI 482
+ +K +R+KE + E ++I
Sbjct: 268 FSDAIDEVQKYNERVKESTLTAIIEPTSNRI 298
>CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1228
Score = 111 bits (278), Expect = 2e-24
Identities = 82/316 (25%), Positives = 152/316 (47%), Gaps = 35/316 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIA-KKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
+ ++G G G V K + D ++ A K+I ++ E L++ LV E+ I+ H ++G
Sbjct: 37 IGELGDGAFGKVEKAVSRTDPKLFAASKSIEIQEGEELEDFLV-EIEILSECKGHPVMLG 95
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
Y ++ N++ +L+E+ G++D I+ V + E + I
Sbjct: 96 LYSTYF---FENKLTMLLEFCGGGAVDNII-----------VELG---HVLKEDQIRYIG 138
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SLADTFVGTST 345
+ V + L +L+ +IHRD+K NIL+ G V++ DFGVS L + DTF+GT
Sbjct: 139 YYVCDALKWLHS-QNVIHRDLKAGNILLTQDGQVRLADFGVSAKLKSEREKRDTFIGTPY 197
Query: 346 YMSP-----ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
+M+P E + Y D+WS G+ +IE++ GE P H D ++ ++ ++
Sbjct: 198 WMAPEVMACETFKDQPYDCISDIWSFGITLIEMAQGEPP---HSDV--SVMRVIIKVQKS 252
Query: 401 PAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCK 460
P L + H++ +D + RC +K+ R R E+ H + + N + K
Sbjct: 253 EPPTLLQPSHWTRSFSDILTRCLVKDPRNRPPAAEIFKHQW---FQNAPSKRKMIMDLLA 309
Query: 461 KVKKRIKEDKMIRREE 476
++ ++E+ +I +E
Sbjct: 310 EMYADVQEEVVIDGDE 325
>Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 968
Score = 110 bits (275), Expect = 5e-24
Identities = 86/317 (27%), Positives = 150/317 (47%), Gaps = 36/317 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ ++G G G V K + + A K I +++E L++ +V E+ I+ H IV
Sbjct: 39 VGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCD-HPYIVKL 96
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
GA+Y+ ++ I++E+ G++D I+ + + C+
Sbjct: 97 LGAYYHDG---KLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQ------------- 140
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
+L L +L+ +IIHRD+K N+L+ +GD+++ DFGVS + +L D+F+GT +
Sbjct: 141 -MLEALNFLHS-KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYW 198
Query: 347 MSPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
M+PE + + Y K D+WSLG+ +IE++ E P HH+ + +L +I
Sbjct: 199 MAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPP---HHELNP--MRVLLKIAKSD 253
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKK 461
P L +S+E DF+ K R S +L+ H F+ T K R +
Sbjct: 254 PPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI----TSNKALRELVAE 309
Query: 462 VKKRIKEDKMIRREETE 478
K + E+ R+E E
Sbjct: 310 AKAEVMEEIEDGRDEGE 326
>7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 1218
Score = 110 bits (275), Expect = 5e-24
Identities = 89/293 (30%), Positives = 145/293 (49%), Gaps = 34/293 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ KIG+G G V K + + + A K I +E + + Q++++ IM H NI+ +
Sbjct: 29 IQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDI--QIIQQEIIMMRDCRHPNIIAY 86
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG++ +++ I ME+ GSL I V T E+ ++ +
Sbjct: 87 YGSYLR---RDKLWICMEFCGGGSLQDIYQV---------------TGPLTEVQIAYMCR 128
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVS---TTLINSLADTFVGTST 345
L GL YL+ K+ HRDIK +NIL+ GDVK+ DFGVS T IN +F+GT
Sbjct: 129 ETLKGLEYLHSMGKM-HRDIKGANILLTEYGDVKLADFGVSAQITATINK-RKSFIGTPY 186
Query: 346 YMSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
+M+PE + G Y D+W+ G+ IEL+ + P+ H P L L+ + +P
Sbjct: 187 WMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLH--PMRALFLMSKSGFKP- 243
Query: 403 PKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI-CKYNNRDTIAKE 454
P L+ + +S +F+ K + R + + L+ H F+ C+ + R +AKE
Sbjct: 244 PTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQCEMSLR--VAKE 294
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 110 bits (274), Expect = 6e-24
Identities = 81/277 (29%), Positives = 137/277 (49%), Gaps = 29/277 (10%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
++ KIG G SGTV + +A K + + +++ K ++ E+ +M+ + H N+V
Sbjct: 432 KMEKIGQGASGTVYTAIESSTGMEVAIKQMNL-SQQPKKELIINEILVMRE-NKHPNVVN 489
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+ ++ + E+ ++MEY+ GSL + V+ +C +E ++ +
Sbjct: 490 YLDSYL---VSEELWVVMEYLPGGSLTDV------------VTETC----MDEGQIAAVC 530
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADTFVGTST 345
VL L +L+ ++IHRDIK NIL+ G VK+ DFG + S T VGT
Sbjct: 531 REVLQALEFLH-ANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPY 589
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
+M+PE + +Y K D+WSLG+M IE+ GE P E L L I P++
Sbjct: 590 WMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPY-----LNENPLKALYLIATNGKPEI 644
Query: 406 SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+ + S DF+++C E R+S +L+ H F+
Sbjct: 645 KEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 681
>At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 487
Score = 109 bits (273), Expect = 8e-24
Identities = 88/342 (25%), Positives = 153/342 (44%), Gaps = 40/342 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVP-DSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
+ KIG G S +V K + +P +S ++A K I ++ + L RE M +S H NI+
Sbjct: 18 ICKIGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLS-HPNILN 76
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSV-YRSDCHRKNVSISCKTSWFNEMPLSRI 286
Y +F + + ++M +M CGSL I+S + S +S+ K +
Sbjct: 77 AYCSF---TVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVFLKET---------- 123
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT------- 339
LN + YL+D +HRDIK NIL++S G VK+ DFGVS ++ + +
Sbjct: 124 ----LNAISYLHD-QGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSS 178
Query: 340 -----FVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDL 393
GT +M+PE + Y K D+WS G+ +EL+ G PL ++ +
Sbjct: 179 LRLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKI 238
Query: 394 LQRI------VNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNN 447
+R +N N+ +S + V C ++ R S ++L+ H F
Sbjct: 239 TKRFHFSDYEINTSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFFKNCKG 298
Query: 448 RDTIAKEFRHWCKKVKKRIKEDKMIRREETERSKIEKRQLEK 489
D + K H ++ E +++ + + + E+ + E+
Sbjct: 299 LDFVVKNVLHSLSNAEQMFMESQILIKSVGDDDEEEEEEDEE 340
>Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 894
Score = 109 bits (272), Expect = 1e-23
Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 29/290 (10%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHD 223
E+ + +IG+G G V K +V + A K I +E E +V++ IM H
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFA--VVQQEIIMMKDCKHP 71
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
NIV ++G++ +++ I ME+ GSL I V T +E+ +
Sbjct: 72 NIVAYFGSYLR---RDKLWICMEFCGGGSLQDIYHV---------------TGPLSELQI 113
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFV 341
+ +S L GL YL+ K+ HRDIK +NIL+ G VK+ DFGVS + ++A +F+
Sbjct: 114 AYVSRETLQGLYYLHSKGKM-HRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFI 172
Query: 342 GTSTYMSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
GT +M+PE + G Y D+W++G+ IEL+ + P+ H P L L+ +
Sbjct: 173 GTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLH--PMRALFLMTKSN 230
Query: 399 NEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNR 448
+P PKL +S FV K + R + ++L+ H F+ ++ R
Sbjct: 231 FQP-PKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTR 279
>CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 378
Score = 109 bits (272), Expect = 1e-23
Identities = 85/326 (26%), Positives = 155/326 (47%), Gaps = 30/326 (9%)
Query: 120 TTRDAPMSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGT 179
T P P V +E + + Q+ + + P N + + + +IG G SGT
Sbjct: 65 TVEPPPPEEPPVRVRASHREKLSDSEVLNQLREI-VNPSNPLGKYEMKK--QIGVGASGT 121
Query: 180 VVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTN 239
V + ++A K + + + K L+ E+ +MK H N+V + ++ + +
Sbjct: 122 VFVANVAGSTDVVAVKRMAFKTQPK-KEMLLTEIKVMKQYR-HPNLVNYIESYLVDA--D 177
Query: 240 EIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYD 299
++ ++M+Y++ G+L ++ KT +E ++ + L L +L+
Sbjct: 178 DLWVVMDYLEGGNLTDVV---------------VKTE-LDEGQIAAVLQECLKALHFLHR 221
Query: 300 CYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI-NSLADTFVGTSTYMSPERIQGGRYT 358
+ I+HRDIK N+L+ G+VK+ D G + S DT VGT +MSPE + +Y
Sbjct: 222 -HSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKRDTVVGTPYWMSPEILNKKQYN 280
Query: 359 TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDF 418
K D+WSLG+M +E+ GE P +TP L + I P++ + + S E +F
Sbjct: 281 YKVDIWSLGIMALEMIDGEPPY--LRETP---LKAIYLIAQNGKPEIKQRDRLSSEFNNF 335
Query: 419 VNRCCIKEERGRSSLKELICHDFICK 444
+++C + + R+ EL+ H F+ K
Sbjct: 336 LDKCLVVDPDQRADTTELLAHPFLKK 361
>CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 545
Score = 108 bits (271), Expect = 1e-23
Identities = 90/293 (30%), Positives = 144/293 (48%), Gaps = 38/293 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG G + TV +P + +A K I +E + ++L E+ M + H N+V +Y +
Sbjct: 63 IGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCN-HPNVVSYYTS 121
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWF---NEMPLSRISF 288
F E+ ++M ++CGS+ IL RK +I + + F +E+ ++ +
Sbjct: 122 FI---AQEELWVVMRLLNCGSMLDILK-------RKVKAIGKEQAQFGVLDEVSIATVLR 171
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--------TF 340
VL GL Y + IHRDIK NIL+ G ++I DFGVS L +S D TF
Sbjct: 172 EVLKGLEYFH-LNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTF 230
Query: 341 VGTSTYMSP---ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRI 397
VGT +M+P E++QG Y K D+WSLG++ IEL++G P +H P + L+ +
Sbjct: 231 VGTPCWMAPEVMEQVQG--YDFKADIWSLGILAIELATGTAP---YHKYPP-MKVLMLTL 284
Query: 398 VNEP------APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
N+P A + + + Y + C K+ R + EL+ + F K
Sbjct: 285 QNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFKK 337
>Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 591
Score = 108 bits (269), Expect = 2e-23
Identities = 89/326 (27%), Positives = 151/326 (46%), Gaps = 30/326 (9%)
Query: 121 TRDAPMSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTV 180
T AP P G Q+E + + A L L + G L KIG G++G V
Sbjct: 277 TPAAPAVPGPPGPRSPQREPQRVSHEQFRAA-LQLVVDPGDPRSYLDNFIKIGEGSTGIV 335
Query: 181 VKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNE 240
+++A K + + K+ + L E+ IM++ H+N+V Y ++ +E
Sbjct: 336 CIATVRSSGKLVAVKKMDLR-KQQRRELLFNEVVIMRDYQ-HENVVEMYNSYL---VGDE 390
Query: 241 IVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDC 300
+ ++ME+++ G+L I++ R NE ++ + VL L L+
Sbjct: 391 LWVVMEFLEGGALTDIVTHTR----------------MNEEQIAAVCLAVLQALSVLH-A 433
Query: 301 YKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTYMSPERIQGGRYT 358
+IHRDIK +IL+ G VK+ DFG + + + VGT +M+PE I Y
Sbjct: 434 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYG 493
Query: 359 TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDF 418
+ D+WSLG+M+IE+ GE P E L ++ I + P+L S + F
Sbjct: 494 PEVDIWSLGIMVIEMVDGEPPYFN-----EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGF 548
Query: 419 VNRCCIKEERGRSSLKELICHDFICK 444
++R +++ R++ EL+ H F+ K
Sbjct: 549 LDRLLVRDPAQRATAAELLKHPFLAK 574
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 108 bits (269), Expect = 2e-23
Identities = 83/284 (29%), Positives = 140/284 (49%), Gaps = 33/284 (11%)
Query: 164 ENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN--QLVRELTIMKNVSA 221
E + L +IG G+ G V + + ++A K + K+ + +++E+ ++ +
Sbjct: 22 ELFIGLHEIGHGSFGAVYFATNAHTNEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLK- 80
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H N + + G + T ++MEY GS +L V++ E+
Sbjct: 81 HPNTIEYKGCYLKEHTA---WLVMEYC-LGSASDLLEVHKKP--------------LQEV 122
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFV 341
++ I+ L+GL YL+ + +IHRDIK NIL+ G VK+ DFG ++ + S A++FV
Sbjct: 123 EIAAITHGALHGLAYLHS-HALIHRDIKAGNILLTEPGQVKLADFGSAS--MASPANSFV 179
Query: 342 GTSTYMSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
GT +M+PE I G+Y K D+WSLG+ IEL+ + PL + + L I
Sbjct: 180 GTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMN-----AMSALYHIA 234
Query: 399 NEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+P L NE ++ FV+ C K + R + EL+ HDF+
Sbjct: 235 QNDSPTLQSNE-WTDSFRRFVDYCLQKIPQERPTSAELLRHDFV 277
>CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 829
Score = 108 bits (269), Expect = 2e-23
Identities = 83/280 (29%), Positives = 142/280 (50%), Gaps = 30/280 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L ++G+G G V K + + A K + +E + + +E+ +++ S H NI+ +
Sbjct: 18 LQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFA-VIQQEIMVIRECS-HPNIIAY 75
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
+G++ + + I+MEY GSL I + T +E+ ++ +
Sbjct: 76 FGSYIR---RDRLWIVMEYCGGGSLQDIYHL---------------TGPLSELQIAFVCR 117
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL++ KI HRDIK +NIL++S GDVK+ DFGV+ + ++ +F+GT +
Sbjct: 118 ETLRGLNYLHNMGKI-HRDIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYW 176
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE + G Y + DVW+ G+ IEL + PL H P +L L+ + +P P
Sbjct: 177 MAPEVACVEKRGGYGMQCDVWATGITAIELGECQPPLFDLH--PMQVLYLMTKSGYKP-P 233
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELI-CHDFI 442
L ++ DFV +C K + R S ++L+ H F+
Sbjct: 234 HLKDKHRWTPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFV 273
>CE01405 [T] KOG0577 Serine/threonine protein kinase
Length = 982
Score = 108 bits (269), Expect = 2e-23
Identities = 88/293 (30%), Positives = 137/293 (46%), Gaps = 37/293 (12%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLK--NQLVRELTIMKNVSAHDNIV 226
L +IG G+ G V + + +A K + K+ ++ N +++E++ + V H +IV
Sbjct: 33 LREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTV-VHPHIV 91
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
+ F +T ++MEY GS I+ V R ++ C +
Sbjct: 92 DYKACFLKDTTC---WLVMEYC-IGSAADIVDVLRKGMREVEIAAICSQT---------- 137
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTY 346
L+ L YL+ K IHRDIK NIL++ VK+ DFG S +L++ A TF+GT +
Sbjct: 138 ----LDALRYLHSL-KRIHRDIKAGNILLSDHAIVKLADFG-SASLVDP-AQTFIGTPFF 190
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE I G YT + D+WSLG+ IEL+ PL + + L I P
Sbjct: 191 MAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMN-----AMSALYHIAQNDPP 245
Query: 404 KL-----SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTI 451
L S+ +S+E F+++C K R S +E H FI + DTI
Sbjct: 246 TLSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTI 298
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 107 bits (267), Expect = 4e-23
Identities = 101/340 (29%), Positives = 157/340 (45%), Gaps = 44/340 (12%)
Query: 170 SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFY 229
S IG GN G V K + I+A K + +E+ + L +E+ + + +
Sbjct: 22 SCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKS-------- 73
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
P TN I ++E D + + C + S K S+ N +P ++SF
Sbjct: 74 -----PLITNYIATMLE-------DVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFI 121
Query: 290 VLN---GLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL-ADTFVGTST 345
+ GL YL++ KI HRDIK +NIL+N +G VK+ DFGVS + ++L DTFVGT
Sbjct: 122 IHEVTLGLKYLHEQRKI-HRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDTFVGTPY 180
Query: 346 YMSPERI--QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
+M+PE + + Y K D+WSLG+ EL G PL + D ++ + N P
Sbjct: 181 WMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKY--------DPMKVMTNLPKR 232
Query: 404 KLSKNE-HYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKY------NNRDTI-AKEF 455
K K + +S DFV C +K R S L+ +F+ ++ D I K+
Sbjct: 233 KPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVKNITITNLKSDVDLIKQKKV 292
Query: 456 RHWCKKVKKRIKEDKMIRREETERSKIEKRQLEKAALAVT 495
+ KV K ++++ + T R K E E L+ T
Sbjct: 293 QERYTKVPKYPLQNRLYKNSNTVRGK-EFWNFESTRLSTT 331
>Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 846
Score = 107 bits (266), Expect = 5e-23
Identities = 82/281 (29%), Positives = 136/281 (48%), Gaps = 29/281 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ ++G+G G V K +V + A K I +E + L+++ M H NIV +
Sbjct: 23 VQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFS--LIQQEIFMVKECKHCNIVAY 80
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
+G++ + ++ I MEY GSL I V T +E+ ++ +
Sbjct: 81 FGSYLS---REKLWICMEYCGGGSLQDIYHV---------------TGPLSELQIAYVCR 122
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTY 346
L GL YL+ K+ HRDIK +NIL+ GDVK+ DFGV+ + ++A +F+GT +
Sbjct: 123 ETLQGLAYLHTKGKM-HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYW 181
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE + G Y D+W++G+ IEL + P+ H P L L+ + +P P
Sbjct: 182 MAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLH--PMRALFLMSKSNFQP-P 238
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
KL +S +FV K + R + + L+ H F+ +
Sbjct: 239 KLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 106 bits (265), Expect = 7e-23
Identities = 90/333 (27%), Positives = 165/333 (49%), Gaps = 43/333 (12%)
Query: 126 MSLTP-TGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTL 184
+S +P + S ++Q + + T TT +L + Q +R + IG+G+ G V +
Sbjct: 56 LSFSPGSSPSFIEQPSPISPTSTTSEDTNTLEEDTDDQSIKWIRGALIGSGSFGQVYLGM 115
Query: 185 HVPDSRIIAKKTIPVENKEVLKNQ-------LVRELTIMKNVSAHDNIVGFYGAFYNPST 237
+ ++A K + +++ K++ L E+ +++ +S H++IV + G+ N
Sbjct: 116 NASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELS-HEHIVQYLGSNLNSDH 174
Query: 238 TNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYL 297
N I +EY+ GS+ +L++Y S F E + L GL YL
Sbjct: 175 LN---IFLEYVPGGSVAGLLTMYGS---------------FEETLVKNFIKQTLKGLEYL 216
Query: 298 YDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-INSLA-------DTFVGTSTYMSP 349
+ I+HRDIK +NIL+++KG +KI DFG+S L +NS + +F G+S +M+P
Sbjct: 217 HS-RGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGARPSFQGSSFWMAP 275
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE 409
E ++ +T K D+WSLG ++IE+ + + P + D + I + + I+ E +S +
Sbjct: 276 EVVKQTMHTEKTDIWSLGCLVIEMLTSKHPY-PNCDQMQAIFRIGENILPEFPSNISSS- 333
Query: 410 HYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
DF+ + + R + EL+ H F+
Sbjct: 334 -----AIDFLEKTFAIDCNLRPTASELLSHPFV 361
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 105 bits (263), Expect = 1e-22
Identities = 81/282 (28%), Positives = 137/282 (47%), Gaps = 36/282 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN-------QLVRELTIMKNVSAHDN 224
IG G G V +++ ++A K + + K +L E+ ++KN+S H N
Sbjct: 74 IGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLS-HPN 132
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
IV + G + N ILME++ GS+ +L + S F E +
Sbjct: 133 IVRYLGTVRESDSLN---ILMEFVPGGSISSLLEKFGS---------------FPEPVII 174
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN----SLADTF 340
+ +L GL YL++ I+HRDIK +NIL+++KG +++ DFG S ++ + A +
Sbjct: 175 MYTKQLLLGLEYLHN-NGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSM 233
Query: 341 VGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
GT +M+PE I ++ D+WS+G +IE+++G+ P + +L + + +
Sbjct: 234 KGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHP 293
Query: 401 PAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P P E S E DF+ +C KE R S EL+ H F+
Sbjct: 294 PIP-----EDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFV 330
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 105 bits (262), Expect = 2e-22
Identities = 78/281 (27%), Positives = 135/281 (47%), Gaps = 35/281 (12%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
R IG G G V K +V R+ A K + +++ + RE+ + ++ NI
Sbjct: 25 RTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITR 84
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+YG++ ++ + I+ME+ GSL +L + D K + +
Sbjct: 85 YYGSYLKDTS---LWIIMEHCAGGSLRSLLRPGKID--EKYIGV---------------- 123
Query: 288 FCVLNGLIYLYDCY---KIIHRDIKPSNILINSKGDVKICDFGVSTTL--INSLADTFVG 342
++ L+ C +IHRDIK +N+LI ++G+VK+CDFGV+ + + T G
Sbjct: 124 --IMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQTMAG 181
Query: 343 TSTYMSPERI-QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
T +M+PE I +G Y TK D+WSLG+ E+++G P L +Q I+
Sbjct: 182 TPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPY-----CDVEALRAMQLIIKSK 236
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P+L ++ YS + +F+ C ++ + R S +L+ FI
Sbjct: 237 PPRL-EDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI 276
>CE27177 [T] KOG4279 Serine/threonine protein kinase
Length = 1378
Score = 105 bits (262), Expect = 2e-22
Identities = 93/339 (27%), Positives = 155/339 (45%), Gaps = 36/339 (10%)
Query: 162 QLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSA 221
+L N +G G GTV + R I K I V+ E ++ L+ E+++ +
Sbjct: 660 ELSNSNERVVLGKGTYGTVYAARDMDTQRQIVVKEIEVKYDEEVQ-PLMEEISLHSTL-C 717
Query: 222 HDNIVGFYGAFY--NPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSW-- 277
H NIV + G + + +I ME++ GSL +L ++ W
Sbjct: 718 HANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLL----------------RSKWGP 761
Query: 278 FNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINS-KGDVKICDFGVSTTL--IN 334
NE ++ +L GL YL++ KI+HRDIK N+L+N+ G KI DFG L +N
Sbjct: 762 MNENAMNYYGKQILEGLKYLHEL-KIVHRDIKGDNVLVNTYSGVCKISDFGTCKRLAGLN 820
Query: 335 SLADTFVGTSTYMSPERIQGGR--YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILD 392
+ +TF GT YM+PE I G+ Y D+WS G ++E+++G P + +
Sbjct: 821 PVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFR 880
Query: 393 LLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIA 452
+ + P P + + +F+ C + E R S K+L+ FI Y+N +I+
Sbjct: 881 VGMFKTHPPIP-----TEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFI--YHNHHSIS 933
Query: 453 KEFRHWCKKVKKRIKEDKMIRREETERSKIEKRQLEKAA 491
+ R K K + +E+ E+SK ++ L +
Sbjct: 934 RT-RSGSINKKPATKIELNHDKEKKEKSKNQREMLRSTS 971
>Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 105 bits (261), Expect = 2e-22
Identities = 93/317 (29%), Positives = 150/317 (46%), Gaps = 34/317 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG+G + V L P +A K I +E + ++L++E+ M S H N+V +Y +
Sbjct: 71 IGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCS-HPNVVTYYTS 129
Query: 232 FYNPSTTNEIVILMEYMDCGS-LDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
F +E+ ++M+ + GS LD I + H+ V E ++ I V
Sbjct: 130 FV---VKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGV--------LEEAIIATILKEV 178
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI-------NSLADTFVGT 343
L GL YL+ +I HRD+K NIL+ G V+I DFGVS L N + TFVGT
Sbjct: 179 LEGLDYLHRNGQI-HRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGT 237
Query: 344 STYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
+M+PE ++ R Y K D+WS G+ IEL++G P +H P + L+ + N+P
Sbjct: 238 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAP---YHKYPP-MKVLMLTLQNDP- 292
Query: 403 PKLSKN-------EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEF 455
P L + Y ++ C K+ R + EL+ F K NR+ + ++
Sbjct: 293 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKL 352
Query: 456 RHWCKKVKKRIKEDKMI 472
+ +R K+ + +
Sbjct: 353 LTRTPDIAQRAKKVRRV 369
>At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 561
Score = 105 bits (261), Expect = 2e-22
Identities = 89/321 (27%), Positives = 156/321 (47%), Gaps = 31/321 (9%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
+IG G S TV + L +P + ++A K + +E + + RE+ M ++ H N++ +
Sbjct: 21 EIGDGVSATVHRALCIPLNVVVAIKVLDLEKCNNDLDGIRREVQTMSLIN-HPNVLQAHC 79
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
+F +T +++ ++M YM GS I+ S F E ++ +
Sbjct: 80 SF---TTGHQLWVVMPYMAGGSCLHIIK-------------SSYPDGFEEPVIATLLRET 123
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS-----LADTFVGTST 345
L L+YL+ + IHRD+K NIL++S G VK+ DFGVS + ++ +TFVGT
Sbjct: 124 LKALVYLH-AHGHIHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQRSRNTFVGTPC 182
Query: 346 YMSPERIQG-GRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPK 404
+M+PE +Q Y K DVWS G+ +EL+ G P + P + LL + N P P
Sbjct: 183 WMAPEVMQQLHGYDFKADVWSFGITALELAHGHAPFSKY--PPMKV--LLMTLQNAP-PG 237
Query: 405 L--SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKV 462
L +++ +S + V C +K+ + R + ++L+ H F D + K + +
Sbjct: 238 LDYERDKRFSKAFKEMVGTCLVKDPKKRPTSEKLLKHPFFKHARPADYLVKTILNGLPPL 297
Query: 463 KKRIKEDKMIRREETERSKIE 483
R ++ K + ++K E
Sbjct: 298 GDRYRQIKSKEADLLMQNKSE 318
>YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1331
Score = 104 bits (260), Expect = 3e-22
Identities = 79/291 (27%), Positives = 131/291 (44%), Gaps = 46/291 (15%)
Query: 170 SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN--QLVRELTIMKNVSAHDNIVG 227
S IG G G V +++ + I+A K I + + +K L++E + + H NIV
Sbjct: 1038 SFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQ 1097
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+YG + N I MEY + GSL +L R + +EM +
Sbjct: 1098 YYGVEVHRDKVN---IFMEYCEGGSLASLLDHGRIE---------------DEMVTQVYT 1139
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT-------- 339
F +L GL YL+ ++HRDIKP NIL++ G +K DFG + T++ S T
Sbjct: 1140 FELLEGLAYLHQS-GVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQD 1198
Query: 340 ----------FVGTSTYMSPERIQGGRYTTK---GDVWSLGLMIIELSSGEFPLGGHHDT 386
+GT YM+PE I G K DVW+LG +++E+++G P
Sbjct: 1199 FGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRP----WSN 1254
Query: 387 PEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELI 437
+ ++ + P+L + + F+ RC +++ R++ EL+
Sbjct: 1255 LDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELL 1305
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 104 bits (259), Expect = 4e-22
Identities = 80/281 (28%), Positives = 131/281 (46%), Gaps = 35/281 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--KEVLKNQLVRELTIMKNVSAHDNIVGFY 229
+G G G V I+A KT+ + ++ Q+ RE+ I N+ H NI+ Y
Sbjct: 124 LGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLR-HKNILRLY 182
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
G F++ I +++E+ G L + L + F+E S+ F
Sbjct: 183 GHFHDEK---RIYLILEFAGRGELYQHLR---------------RAKRFSEEVASKYIFQ 224
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
+ N L YL+ + +IHRDIKP NIL+ G++K+ DFG S ++ T GT Y+ P
Sbjct: 225 MANALSYLHKKH-VIHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRRTTLCGTLDYLPP 283
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFP---LGGHHDTPEGILDLLQRIVNEPAPKLS 406
E ++G +T K D+WSLG++ E G P + GH T + I + +I + P
Sbjct: 284 EMVEGKEHTEKVDLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVDLKIPSFVPP--- 340
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNN 447
+ D ++R R SL++++ H +I KY +
Sbjct: 341 -------DARDLISRLLQHNPEKRMSLEQVMRHPWIVKYKD 374
>CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 572
Score = 103 bits (257), Expect = 6e-22
Identities = 84/315 (26%), Positives = 144/315 (45%), Gaps = 33/315 (10%)
Query: 132 GVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRI 191
GV Q+ + T + +L G ++ KIG+G SG+V + +
Sbjct: 261 GVQARGQKAKKKMTDAEVLTKLRTIVSIGNPDRKYRKVDKIGSGASGSVYTAIEISTEAE 320
Query: 192 IAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCG 251
+A K + ++++ K ++ E+ +M+ + H NIV + ++ +E+ ++MEY+ G
Sbjct: 321 VAIKQMNLKDQPK-KELIINEILVMRE-NKHANIVNYLDSYL---VCDELWVVMEYLAGG 375
Query: 252 SLDKILSVYRSDCHRKN--VSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIK 309
SL +++ +C ++ ++ C+ VL L +L+ + +IHRDIK
Sbjct: 376 SLTDVVT----ECQMEDGIIAAVCRE--------------VLQALEFLHSRH-VIHRDIK 416
Query: 310 PSNILINSKGDVKICDFGVSTTLI--NSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLG 367
NIL+ G VK+ DFG L T VGT +M+PE + +Y K DVWSLG
Sbjct: 417 SDNILLGMDGSVKLTDFGFCAQLSPEQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLG 476
Query: 368 LMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEE 427
+M IE+ GE P E L + I P + ++ DFV+ +
Sbjct: 477 IMAIEMVEGEPPY-----LNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQV 531
Query: 428 RGRSSLKELICHDFI 442
R S +L+ H F+
Sbjct: 532 ENRWSASQLLTHPFL 546
>Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 455
Score = 103 bits (256), Expect = 8e-22
Identities = 98/371 (26%), Positives = 164/371 (43%), Gaps = 62/371 (16%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAH 222
+E L K+G G+ GTV+K H +I+A K ++ + +RE+ +K H
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFH-H 59
Query: 223 DNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMP 282
+N+V F +I ++ E++D LD++ + CH
Sbjct: 60 ENLVNLIEVFRQKK---KIHLVFEFIDHTVLDEL----QHYCHG-----------LESKR 101
Query: 283 LSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADTF 340
L + F +L + YL+ IIHRDIKP NIL++ G K+CDFG + TL + +
Sbjct: 102 LRKYLFQILRAIDYLHS-NNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDY 160
Query: 341 VGTSTYMSPERI-QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVN 399
V T Y +PE + + Y D+W+LG MIIE+++G L D LDLL +IV
Sbjct: 161 VATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSD-----LDLLHKIVL 215
Query: 400 EPA--------------------------PKLSKNEHYSIE--MTDFVNRCCIKEERGRS 431
+ PK ++ ++ + + D V+ C + R
Sbjct: 216 KVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRI 275
Query: 432 SLKELICHDFICKYNNRDTIAKEFRHWCK-KVKKRIKEDKMIRREETERSKIEKRQLEKA 490
S +L+ H+ Y RD ++F K K+ + K + +I+ +E+ + E R+ E+
Sbjct: 276 SSSDLLHHE----YFTRDGFIEKFMPELKAKLLQEAKVNSLIKPKESSKEN-ELRKDERK 330
Query: 491 ALAVTAARSSS 501
+ SSS
Sbjct: 331 TVYTNTLLSSS 341
>ECU07g0360 [D] KOG0580 Serine/threonine protein kinase
Length = 272
Score = 103 bits (256), Expect = 8e-22
Identities = 76/281 (27%), Positives = 125/281 (44%), Gaps = 27/281 (9%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN--QLVRELTIMKNVSAHDNIVGFY 229
+G G G V I+A K IP++ + ++ Q+ RE+ I N+ H NI+ Y
Sbjct: 16 LGRGKFGQVWLAREREKGFIVALKIIPIKEIQTVETARQIRREIEIHSNLK-HPNILRMY 74
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
G F++ + I +++EY G K LS K S+ +
Sbjct: 75 GHFHDK---DNIYLILEYAGKGEFFKFLSDRGGKFGEKETSLYIRQ-------------- 117
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
V+ L Y+ +C +IHRDIKP N+L+ S +KI DFG + + TF GT Y++P
Sbjct: 118 VMLALTYMKEC-NVIHRDIKPENLLLGSDNQLKIADFGWAVYNADKRRMTFCGTMEYLAP 176
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE 409
E + + + D+W LG++ E G+ P + + + K + E
Sbjct: 177 EMVNNDIHDSGIDLWCLGILTYEFLMGKTPFESKNRNMREAYKKINSL------KYTIPE 230
Query: 410 HYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDT 450
S +DF++R + R L E + H FI K++ R +
Sbjct: 231 TISSNASDFISRLLVLSPGDRMELTEALNHPFIVKHHGRSS 271
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 102 bits (255), Expect = 1e-21
Identities = 87/291 (29%), Positives = 137/291 (46%), Gaps = 34/291 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN--QLVRELTIMKNVSAHDNIV 226
L +IG G+ G V I+A K + K+ + +++E+ ++ ++ H N +
Sbjct: 30 LREIGHGSFGAVYYARCNLTREIVAIKKMSYTGKQSQEKWQDILKEIRFLRQLN-HPNTI 88
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
+ G + ST ++MEY GS I+ V++ H ++ C
Sbjct: 89 EYKGCYLRESTA---WLVMEYC-VGSASDIIEVHKKPLHEDEIAAIC------------- 131
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTY 346
VL+GL YL+ +I HRDIK NIL+ G VK+ DFG + I A++FVGT +
Sbjct: 132 -LGVLSGLSYLHSLGRI-HRDIKAGNILLTDNGVVKLADFG--SAAIKCPANSFVGTPYW 187
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE I G+Y K DVWSLG+ IEL+ + P + + L I +P
Sbjct: 188 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMN-----AMSALYHIAQNESP 242
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
L KN+ +S FV C K R S +L+ H ++ + + DT+ E
Sbjct: 243 TLPKND-WSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRS-DTVLLE 291
>Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 820
Score = 102 bits (254), Expect = 1e-21
Identities = 84/278 (30%), Positives = 135/278 (48%), Gaps = 29/278 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L ++GAG G V K S + A K + ++ + + + L +E+TI++ H N+V +
Sbjct: 19 LQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISS-LQQEITILRECR-HPNVVAY 76
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
G++ + + I ME+ GSL +I T E ++ +
Sbjct: 77 IGSYLR---NDRLWICMEFCGGGSLQEIYHA---------------TGPLEERQIAYVCR 118
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVGTSTY 346
L GL +L+ KI HRDIK +N+L+ +GDVK+ DFGVS L S+A +F+GT +
Sbjct: 119 EALKGLHHLHSQGKI-HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYW 177
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE + G Y DVW+LG+ IEL + PL H P L L+ + +P P
Sbjct: 178 MAPEVAAVERKGGYNELCDVWALGITAIELGELQPPL--FHLHPMRALMLMSKSSFQP-P 234
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDF 441
KL ++ F+ K + R + ++L+ H F
Sbjct: 235 KLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPF 272
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 102 bits (253), Expect = 2e-21
Identities = 88/281 (31%), Positives = 128/281 (45%), Gaps = 38/281 (13%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTI------PVENKEVLKNQLVRELTIMKNVSAHDNI 225
+G G G V V R +A K + P +KEV + L E+ ++KN+ H+ I
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEV--SALECEIQLLKNLQ-HERI 424
Query: 226 VGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSR 285
V +YG + + + I MEYM GS+ L Y + E +
Sbjct: 425 VQYYGCLRDRAEKT-LTIFMEYMPGGSVKDQLKAYGA---------------LTESVTRK 468
Query: 286 ISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD-----TF 340
+ +L G+ YL+ I+HRDIK +NIL +S G+VK+ DFG S L +
Sbjct: 469 YTRQILEGMSYLHS-NMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSV 527
Query: 341 VGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
GT +MSPE I G Y K DVWSLG ++E+ + E P ++ I + + N
Sbjct: 528 TGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT-EKPPWAEYEAMAAIFKIATQPTNP 586
Query: 401 PAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDF 441
P H S DF+ R + E R R S +EL+ H F
Sbjct: 587 QLP-----SHISEHGRDFLRRIFV-EARQRPSAEELLTHHF 621
>Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 302
Score = 102 bits (253), Expect = 2e-21
Identities = 75/274 (27%), Positives = 136/274 (49%), Gaps = 25/274 (9%)
Query: 154 SLTPENGIQ-LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQL--V 210
+L P+ G L N KIG G V + + D +A K + + + K + +
Sbjct: 21 ALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCI 80
Query: 211 RELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVS 270
+E+ ++K ++ H N++ +Y +F NE+ I++E D G L +++ ++ ++
Sbjct: 81 KEIDLLKQLN-HPNVIKYYASFIED---NELNIVLELADAGDLSRMIKHFK----KQKRL 132
Query: 271 ISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVST 330
I +T W + L + L +++ +++HRDIKP+N+ I + G VK+ D G+
Sbjct: 133 IPERTVWKYFVQLC-------SALEHMHS-RRVMHRDIKPANVFITATGVVKLGDLGLGR 184
Query: 331 TLIN--SLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPE 388
+ + A + VGT YMSPERI Y K D+WSLG ++ E+++ + P G
Sbjct: 185 FFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLY 244
Query: 389 GILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRC 422
+ +++ P P ++HYS E+ VN C
Sbjct: 245 SLCKKIEQCDYPPLP----SDHYSEELRQLVNMC 274
>HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 819
Score = 101 bits (252), Expect = 2e-21
Identities = 83/278 (29%), Positives = 135/278 (47%), Gaps = 29/278 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L ++GAG G V K S + A K + ++ + + + L +E+TI++ H N+V +
Sbjct: 18 LQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISS-LQQEITILRECR-HPNVVAY 75
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
G++ + + I ME+ GSL +I + ++ C+
Sbjct: 76 IGSYLR---NDRLWICMEFCGGGSLQEIYHA-TGPLEERQIAYVCRER------------ 119
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TFVGTSTY 346
L GL +L+ KI HRDIK +N+L+ +GDVK+ DFGVS L S+A +F+GT +
Sbjct: 120 --LKGLHHLHSQGKI-HRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYW 176
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE + G Y DVW+LG+ IEL + PL H P L L+ + +P P
Sbjct: 177 MAPEVAAVERKGGYNELCDVWALGITAIELGELQPPL--FHLHPMRALMLMSKSSFQP-P 233
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDF 441
KL ++ F+ K + R + ++L+ H F
Sbjct: 234 KLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPF 271
>Hs7706401 [T] KOG0577 Serine/threonine protein kinase
Length = 1235
Score = 101 bits (252), Expect = 2e-21
Identities = 81/281 (28%), Positives = 141/281 (49%), Gaps = 33/281 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN--QLVRELTIMKNVSAHDNIV 226
L +IG G+ G V V +S ++A K + K+ + +++E+ ++ + H N +
Sbjct: 31 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLR-HPNTI 89
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
+ G + T ++MEY GS +L V++ E+ ++ +
Sbjct: 90 QYRGCYLREHTA---WLVMEYC-LGSASDLLEVHKKP--------------LQEVEIAAV 131
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTY 346
+ L GL YL+ + +IHRD+K NIL++ G VK+ DFG ++ I + A++FVGT +
Sbjct: 132 THGALQGLAYLHS-HNMIHRDVKAGNILLSEPGLVKLGDFGSAS--IMAPANSFVGTPYW 188
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE I G+Y K DVWSLG+ IEL+ + PL + + L I +P
Sbjct: 189 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMN-----AMSALYHIAQNESP 243
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
L ++ H+S +FV+ C K + R + + L+ H F+ +
Sbjct: 244 VL-QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLR 283
>Hs4759208 [T] KOG0577 Serine/threonine protein kinase
Length = 1049
Score = 101 bits (252), Expect = 2e-21
Identities = 81/281 (28%), Positives = 141/281 (49%), Gaps = 33/281 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN--QLVRELTIMKNVSAHDNIV 226
L +IG G+ G V V +S ++A K + K+ + +++E+ ++ + H N +
Sbjct: 31 LREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLR-HPNTI 89
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
+ G + T ++MEY GS +L V++ E+ ++ +
Sbjct: 90 QYRGCYLREHTA---WLVMEYC-LGSASDLLEVHKKP--------------LQEVEIAAV 131
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTY 346
+ L GL YL+ + +IHRD+K NIL++ G VK+ DFG ++ I + A++FVGT +
Sbjct: 132 THGALQGLAYLHS-HNMIHRDVKAGNILLSEPGLVKLGDFGSAS--IMAPANSFVGTPYW 188
Query: 347 MSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
M+PE I G+Y K DVWSLG+ IEL+ + PL + + L I +P
Sbjct: 189 MAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMN-----AMSALYHIAQNESP 243
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
L ++ H+S +FV+ C K + R + + L+ H F+ +
Sbjct: 244 VL-QSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLR 283
>Hs4505649 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 523
Score = 101 bits (252), Expect = 2e-21
Identities = 79/270 (29%), Positives = 132/270 (48%), Gaps = 35/270 (12%)
Query: 152 RLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVR 211
R SL+ ++E ++L K+G G TV K ++A K I +E++E +R
Sbjct: 178 RASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIR 237
Query: 212 ELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSI 271
E++++K++ H NIV + + T + ++ EY LDK L Y DC
Sbjct: 238 EVSLLKDLK-HANIVTLHDIVH---TDKSLTLVFEY-----LDKDLKQYMDDCG------ 282
Query: 272 SCKTSWFNEMPLSRIS---FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGV 328
N M + + + +L GL Y + K++HRD+KP N+LIN KG++K+ DFG+
Sbjct: 283 -------NIMSMHNVKLFLYQILRGLAYCHR-RKVLHRDLKPQNLLINEKGELKLADFGL 334
Query: 329 --STTLINSLADTFVGTSTYMSPERIQG-GRYTTKGDVWSLGLMIIELSSGEFPLGGHHD 385
+ ++ V T Y P+ + G Y T+ D+W +G + E++SG G
Sbjct: 335 ARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYLTQIDMWGVGCIFFEMASGRPLFPG--S 392
Query: 386 TPEGILDLLQRIVNEPA----PKLSKNEHY 411
T E L L+ R++ P+ P +S NE +
Sbjct: 393 TVEDELHLIFRLLGTPSQETWPGISSNEEF 422
>Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 313
Score = 101 bits (252), Expect = 2e-21
Identities = 75/267 (28%), Positives = 127/267 (47%), Gaps = 24/267 (8%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLK--NQLVRELTIMKNVSAHDNIVGF 228
KIG G V K + D + +A K + + K V+E+ ++K ++ H NI+ +
Sbjct: 50 KIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLN-HPNIIKY 108
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
+F NE+ I++E D G L +++ ++ ++ I +T W F
Sbjct: 109 LDSFIED---NELNIVLELADAGDLSQMIKYFK----KQKRLIPERTVWKY--------F 153
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SLADTFVGTSTY 346
L + +++HRDIKP+N+ I + G VK+ D G+ + + A + VGT Y
Sbjct: 154 VQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYY 213
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
MSPERI Y K D+WSLG ++ E+++ + P G + L Q+I P L
Sbjct: 214 MSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYG---DKMNLFSLCQKIEQCDYPPL- 269
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSL 433
EHYS ++ + V+ C + R +
Sbjct: 270 PGEHYSEKLRELVSMCICPDPHQRPDI 296
>Hs5453860 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 496
Score = 100 bits (250), Expect = 4e-21
Identities = 78/273 (28%), Positives = 134/273 (48%), Gaps = 29/273 (10%)
Query: 146 LTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVL 205
L+ ++ R+SL+ +LE ++L K+G G TV K ++A K I +E++E
Sbjct: 145 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA 204
Query: 206 KNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCH 265
+RE++++K++ H NIV + + T + ++ EY LDK L Y DC
Sbjct: 205 PCTAIREVSLLKDLK-HANIVTLHDIIH---TEKSLTLVFEY-----LDKDLKQYLDDCG 255
Query: 266 RKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICD 325
+ N + F +L GL Y + K++HRD+KP N+LIN +G++K+ D
Sbjct: 256 ----------NIINMHNVKLFLFQLLRGLAYCHR-QKVLHRDLKPQNLLINERGELKLAD 304
Query: 326 FGV--STTLINSLADTFVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGG 382
FG+ + ++ V T Y P+ + G Y+T+ D+W +G + E+++G G
Sbjct: 305 FGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG 364
Query: 383 HHDTPEGILDLLQRIVNEPA----PKLSKNEHY 411
T E L + RI+ P P + NE +
Sbjct: 365 --STVEEQLHFIFRILGTPTEETWPGILSNEEF 395
>Hs15011928 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 448
Score = 100 bits (250), Expect = 4e-21
Identities = 78/273 (28%), Positives = 134/273 (48%), Gaps = 29/273 (10%)
Query: 146 LTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVL 205
L+ ++ R+SL+ +LE ++L K+G G TV K ++A K I +E++E
Sbjct: 97 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA 156
Query: 206 KNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCH 265
+RE++++K++ H NIV + + T + ++ EY LDK L Y DC
Sbjct: 157 PCTAIREVSLLKDLK-HANIVTLHDIIH---TEKSLTLVFEY-----LDKDLKQYLDDCG 207
Query: 266 RKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICD 325
+ N + F +L GL Y + K++HRD+KP N+LIN +G++K+ D
Sbjct: 208 ----------NIINMHNVKLFLFQLLRGLAYCHR-QKVLHRDLKPQNLLINERGELKLAD 256
Query: 326 FGV--STTLINSLADTFVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGG 382
FG+ + ++ V T Y P+ + G Y+T+ D+W +G + E+++G G
Sbjct: 257 FGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPG 316
Query: 383 HHDTPEGILDLLQRIVNEPA----PKLSKNEHY 411
T E L + RI+ P P + NE +
Sbjct: 317 --STVEEQLHFIFRILGTPTEETWPGILSNEEF 347
>SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 288
Score = 100 bits (249), Expect = 5e-21
Identities = 70/241 (29%), Positives = 125/241 (51%), Gaps = 25/241 (10%)
Query: 165 NLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDN 224
N RL K+G G V K + I+A K I ++ E + +RE+++MK + H N
Sbjct: 2 NYQRLEKLGEGTYAHVYKGQNRVTGEIVALKVIRIDADEGTPSTAIREISLMKELR-HPN 60
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
I+ T N+++++ EYM+ K L Y + + F + L
Sbjct: 61 IMSLSDVL---QTENKLMLVFEYME-----KDLKKYMDTYGNQGALPPSQVKNFTQQLLK 112
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL---INSLADTFV 341
ISFC N +++HRD+KP N+LINS+G++K+ DFG++ ++ +N+ ++ V
Sbjct: 113 GISFCHEN---------RVLHRDLKPQNLLINSRGELKLADFGLARSIGIPVNTFSNEVV 163
Query: 342 GTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
T Y +P+ + G R Y+T D+WS+G ++ E+++G PL + + +L + R++
Sbjct: 164 -TLWYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGR-PLFAGSNNEDQLLKIF-RLLGT 220
Query: 401 P 401
P
Sbjct: 221 P 221
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 100 bits (249), Expect = 5e-21
Identities = 87/328 (26%), Positives = 154/328 (46%), Gaps = 46/328 (14%)
Query: 154 SLTPENG--IQLENLVRLSK---IGAGNSGTVVKTLHVPDSRIIAKKTIPV-------EN 201
S +P N +Q++ +R K IG G GTV +++ ++A K + + E
Sbjct: 51 SQSPPNNSTVQIKPPIRWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLITSNCASKEK 110
Query: 202 KEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYR 261
+ +L E+ ++KN+S H NIV + G T N IL+E++ GS+ +L +
Sbjct: 111 TQAHIQELEEEVKLLKNLS-HPNIVRYLGTVREDETLN---ILLEFVPGGSISSLLEKFG 166
Query: 262 SDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDV 321
+ F E + + +L GL YL++ + I+HRDIK +NIL++++G +
Sbjct: 167 A---------------FPESVVRTYTNQLLLGLEYLHN-HAIMHRDIKGANILVDNQGCI 210
Query: 322 KICDFGVSTTLIN----SLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGE 377
K+ DFG S + S A + GT +M+PE I ++ D+WS+G +IE+ +G+
Sbjct: 211 KLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGK 270
Query: 378 FPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELI 437
P + I + + P P ++ S + DF+ +C +E R + EL+
Sbjct: 271 APWSQQYKEIAAIFHIGTTKSHPPIP-----DNISSDANDFLLKCLQQEPNLRPTASELL 325
Query: 438 -----CHDFICKYNNRDTIAKEFRHWCK 460
+ + N R+ K H C+
Sbjct: 326 KVKWSTDIHLLRANRRNLRLKILLHLCQ 353
>CE04493 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kinase
MKK3/MKK6
Length = 449
Score = 100 bits (248), Expect = 7e-21
Identities = 80/253 (31%), Positives = 127/253 (49%), Gaps = 35/253 (13%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPV--------ENKEVLKNQLVRELTIMKNVSAH 222
+IG G + V L + + ++IA+K + V ++ L + +RE+ ++ +
Sbjct: 209 RIGNGEGQSAVYRL-IYNGKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGCAPC 267
Query: 223 DNIVGFYGAFYNP-STTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
IV F+G + + +I I ME M + SV +++ ++ +I E
Sbjct: 268 PFIVHFFGYYVHKYRDCVKIHIFMEEMALSA-----SVLKTEALKQGGAIP-------EF 315
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFV 341
+ RI V++ + +L D +IIHRDIKP NILI+ G VKICDFG+ L NS+A +
Sbjct: 316 VIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSIAVSDT 375
Query: 342 GTSTYMSPERIQGG-----RYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILD--LL 394
G Y +PE + G Y+ K D+WSLG+ I EL++ +P P G + LL
Sbjct: 376 GCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFELATLRYPY------PVGFSEFTLL 429
Query: 395 QRIVNEPAPKLSK 407
IV PAP L +
Sbjct: 430 SAIVTTPAPYLER 442
>YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 305
Score = 99.0 bits (245), Expect = 1e-20
Identities = 71/242 (29%), Positives = 125/242 (51%), Gaps = 22/242 (9%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVG 227
+L K+G G TV K L+ +A K + ++++E + +RE+++MK + H+NIV
Sbjct: 9 QLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK-HENIVR 67
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
Y + T N++ ++ E+MD L K + + + ++ +F L ++
Sbjct: 68 LYDVIH---TENKLTLVFEFMD-NDLKKYMDSRTVGNTPRGLELNL-VKYFQWQLLQGLA 122
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL---INSLADTFVGTS 344
FC N KI+HRD+KP N+LIN +G +K+ DFG++ +N+ + V T
Sbjct: 123 FCHEN---------KILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV-TL 172
Query: 345 TYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
Y +P+ + G R Y+T D+WS G ++ E+ +G+ G +D E L L+ I+ P
Sbjct: 173 WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND--EEQLKLIFDIMGTPNE 230
Query: 404 KL 405
L
Sbjct: 231 SL 232
>SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 722
Score = 99.0 bits (245), Expect = 1e-20
Identities = 94/371 (25%), Positives = 154/371 (41%), Gaps = 54/371 (14%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVR-ELTIMKNVSA 221
+E L IG G+ G + K + D ++A+K I N + Q + E+ I++N+
Sbjct: 1 MEKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLK- 59
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSD------------------ 263
H NIV + G N S I + MEY G L ++ Y+ +
Sbjct: 60 HPNIVQYCGEELNRSA-QVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLL 118
Query: 264 ----CHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKG 319
CH + +C + W E+ + ++HRDIKP+NI ++
Sbjct: 119 ALYRCHYGENAPACDSQWPREI---------------FHPKQSVLHRDIKPANIFLDENN 163
Query: 320 DVKICDFGVSTTLINS--LADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGE 377
VK+ DFG+S L N+ ++VGT YMSPE I+ Y+ K DVW+LG +I E+
Sbjct: 164 SVKLGDFGLSKLLDNTRVFTQSYVGTPYYMSPEIIRSSPYSAKSDVWALGCVIFEICMLT 223
Query: 378 FPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSS----L 433
P G L+L + I + HYS ++ + C R + L
Sbjct: 224 HPFEG-----RSYLELQRNICQ--GNLSCWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLL 276
Query: 434 KELICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMIRREETERSKIEKRQLEKAALA 493
+ I D K + + ++ KK + I+ + ++ E +R + +LE +
Sbjct: 277 RSPILSDIRSKLESERVVLEQSDLLHKKHQMLIQLENDLQFRE-QRLSARESELENVIAS 335
Query: 494 VTAARSSSTRR 504
A R RR
Sbjct: 336 RLAQREEILRR 346
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 98.6 bits (244), Expect = 2e-20
Identities = 81/311 (26%), Positives = 142/311 (45%), Gaps = 37/311 (11%)
Query: 158 ENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMK 217
EN +L +G G+ G V + + +A K + ++ E + + +E+ ++
Sbjct: 2 ENNTASSPYTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLS 61
Query: 218 NVSAHD--NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKT 275
+ D NI+ ++G++ + I+M+Y CH +V +
Sbjct: 62 ELKQSDVENIIKYHGSYL---VGTNLWIIMDY----------------CHGGSVRTLMEA 102
Query: 276 SWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-IN 334
+E +S I L L +++ IIHRDIK +NIL++ G+VK+CDFGV+ L IN
Sbjct: 103 GPISEPCISLILRETLQALKFIHHA-GIIHRDIKAANILVSMSGNVKLCDFGVAAELNIN 161
Query: 335 SLAD-TFVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILD 392
TF+GT +M+PE I+ G+ Y D+WSLG+ E+++G P E
Sbjct: 162 RRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYEIATGSPP-----HAKEDPFR 216
Query: 393 LLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRD--- 449
+ I + P+L N ++S + +F+ C + R EL+ FI +Y+
Sbjct: 217 AVYLIAHTAPPRL--NGNFSALLKEFIASCLQDVPQRRLDSSELLKSKFIKQYSRMSISE 274
Query: 450 --TIAKEFRHW 458
+ K + W
Sbjct: 275 LTNVVKRYDTW 285
>At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 710
Score = 98.6 bits (244), Expect = 2e-20
Identities = 78/285 (27%), Positives = 135/285 (47%), Gaps = 36/285 (12%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ +IG G S V + +++P + ++A K + ++ + + RE M + H N++
Sbjct: 36 MEEIGHGASAVVYRAIYLPTNEVVAIKCLDLDRCNSNLDDIRRESQTMSLID-HPNVIKS 94
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
+ +F S + + ++M +M GS ++ SD F E + +
Sbjct: 95 FCSF---SVDHSLWVVMPFMAQGSCLHLMKTAYSD-------------GFEESAICCVLK 138
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS-----LADTFVGT 343
L L YL+ IHRD+K NIL++ G++K+ DFGVS L ++ +TFVGT
Sbjct: 139 ETLKALDYLHR-QGHIHRDVKAGNILLDDNGEIKLGDFGVSACLFDNGDRQRARNTFVGT 197
Query: 344 STYMSPERIQ-GGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
+M+PE +Q G Y +K D+WS G+ +EL+ G P + P + LL I N P
Sbjct: 198 PCWMAPEVLQPGNGYNSKADIWSFGITALELAHGHAPFSKY--PPMKV--LLMTIQNAPP 253
Query: 403 -------PKLSKNEHYSIE-MTDFVNRCCIKEERGRSSLKELICH 439
K SK + + V C +K++ R + ++L+ H
Sbjct: 254 GLDYDRDKKFSKRTFSCAQSFKEMVAMCLVKDQTKRPTAEKLLKH 298
>At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 277
Score = 98.6 bits (244), Expect = 2e-20
Identities = 87/301 (28%), Positives = 140/301 (45%), Gaps = 49/301 (16%)
Query: 162 QLENLVRL-SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELT-----I 215
+LEN +L +IG G GT+ + A KTI +K VL + L RE I
Sbjct: 6 ELENNYQLCDEIGRGRFGTITRCFSPATKEFYACKTI---DKRVLIDALDRECIETEPRI 62
Query: 216 MKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMD--CGSLDKILSVYRSDCHRKNVSISC 273
M + H NI+ + + T + + I+ME +D D+++S +S S
Sbjct: 63 MAMLPPHPNIIRIFDLY---ETEDSLAIVMELVDPPMTIYDRLISA------GGRLSESE 113
Query: 274 KTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINS-KGDVKICDFGVSTTL 332
S+ + +L+ L + + C ++HRD+KP N+L++ G VK+CDFG + L
Sbjct: 114 SASYAKQ---------ILSALAHCHRC-DVVHRDVKPDNVLVDLVSGGVKLCDFGSAVWL 163
Query: 333 INSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILD 392
A+ VGT Y++PE + G +Y K D+WS G++I + +GE P G +T E I +
Sbjct: 164 GGETAEGVVGTPYYVAPEVVMGRKYDEKVDIWSAGVVIYTMLAGEPPFNG--ETAEDIFE 221
Query: 393 LLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIA 452
+ R PK K S E D L+++IC D +++ D +
Sbjct: 222 SILRGNLRFPPK--KFGSVSSEAKDL--------------LRKMICRDVSRRFSAEDALR 265
Query: 453 K 453
K
Sbjct: 266 K 266
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 98.6 bits (244), Expect = 2e-20
Identities = 78/282 (27%), Positives = 134/282 (46%), Gaps = 36/282 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPV-------ENKEVLKNQLVRELTIMKNVSAHDN 224
IG G GTV +++ ++A K + + E + +L E+ ++KN+S H N
Sbjct: 75 IGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLS-HPN 133
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
IV + G T N IL+E++ GS+ +L K F E +
Sbjct: 134 IVRYLGTVREDDTLN---ILLEFVPGGSISSLLE---------------KFGPFPESVVR 175
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN----SLADTF 340
+ +L GL YL++ + I+HRDIK +NIL+++KG +K+ DFG S + + A +
Sbjct: 176 TYTRQLLLGLEYLHN-HAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSM 234
Query: 341 VGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
GT +M+PE I ++ D+WS+G +IE+ +G+ P + I + +
Sbjct: 235 KGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHP 294
Query: 401 PAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P P + S + DF+ +C + R + EL+ H F+
Sbjct: 295 PIP-----DTLSSDAKDFLLKCLQEVPNLRPTASELLKHPFV 331
>Hs5174547 [T] KOG4279 Serine/threonine protein kinase
Length = 1374
Score = 98.2 bits (243), Expect = 3e-20
Identities = 88/280 (31%), Positives = 129/280 (45%), Gaps = 36/280 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V + + IA K IP E L E+ + K++ H NIV + G+
Sbjct: 686 LGKGTYGIVYAGRDLSNQVRIAIKEIP-ERDSRYSQPLHEEIALHKHLK-HKNIVQYLGS 743
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWF----NEMPLSRIS 287
F S I I ME + GSL +L ++ W NE + +
Sbjct: 744 F---SENGFIKIFMEQVPGGSLSALL----------------RSKWGPLKDNEQTIGFYT 784
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINS-KGDVKICDFGVSTTL--INSLADTFVGTS 344
+L GL YL+D +I+HRDIK N+LIN+ G +KI DFG S L IN +TF GT
Sbjct: 785 KQILEGLKYLHD-NQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTL 843
Query: 345 TYMSPERIQGGR--YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
YM+PE I G Y D+WSLG IIE+++G+ P + + + V+
Sbjct: 844 QYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI 903
Query: 403 PKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P E S E F+ +C + R+ +L+ +F+
Sbjct: 904 P-----ESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL 938
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 98.2 bits (243), Expect = 3e-20
Identities = 84/278 (30%), Positives = 136/278 (48%), Gaps = 34/278 (12%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPV--ENKEVLKNQLVRELTIMKNVSAHDNIV 226
L IG G+ G V K ++++A K IP +++ L+N L RE+ IM+ + H NIV
Sbjct: 7 LEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLR-HPNIV 64
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
+F T E+V++ +Y + G L +IL E + I
Sbjct: 65 HMLDSF---ETDKEVVVVTDYAE-GELFQILE---------------DDGKLPEDQVQAI 105
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-INSLADTFV-GTS 344
+ +++ L YL+ ++I+HRD+KP NIL+ G +K+CDFG + + N++ T + GT
Sbjct: 106 AAQLVSALYYLHS-HRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTP 164
Query: 345 TYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPK 404
YMSPE ++ Y D+WS+G ++ EL+ G P I L+ I+ +P
Sbjct: 165 LYMSPELVEERPYDHTADLWSVGCILYELAVGTPPF-----YATSIFQLVSLILKDPVRW 219
Query: 405 LSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
S S +F+ K+ R R S +L+ H FI
Sbjct: 220 PST---ISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 693
Score = 97.8 bits (242), Expect = 3e-20
Identities = 77/288 (26%), Positives = 142/288 (48%), Gaps = 38/288 (13%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+ ++G G S V + +++P + ++A K++ ++ + + RE M + H N++
Sbjct: 30 MEEVGYGASAVVHRAIYLPTNEVVAIKSLDLDRCNSNLDDIRREAQTMTLID-HPNVIKS 88
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
+ +F + + + ++M +M GS ++ D F E + +
Sbjct: 89 FCSF---AVDHHLWVVMPFMAQGSCLHLMKAAYPD-------------GFEEAAICSMLK 132
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS-----LADTFVGT 343
L L YL+ IHRD+K NIL++ G++K+ DFGVS L ++ +TFVGT
Sbjct: 133 ETLKALDYLHR-QGHIHRDVKAGNILLDDTGEIKLGDFGVSACLFDNGDRQRARNTFVGT 191
Query: 344 STYMSPERIQ-GGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
+M+PE +Q G Y +K D+WS G+ +EL+ G P + P + LL I N P
Sbjct: 192 PCWMAPEVLQPGSGYNSKADIWSFGITALELAHGHAPFSKY--PPMKV--LLMTIQNAP- 246
Query: 403 PKL--SKNEHYSIEMT-------DFVNRCCIKEERGRSSLKELICHDF 441
P L +++ +S +M+ + V C +K++ R + ++L+ H F
Sbjct: 247 PGLDYDRDKKFSKKMSSCAQSFKELVALCLVKDQTKRPTAEKLLKHSF 294
>At1g05100 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 339
Score = 97.8 bits (242), Expect = 3e-20
Identities = 80/322 (24%), Positives = 141/322 (42%), Gaps = 40/322 (12%)
Query: 165 NLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDN 224
N R +G G++ TV +A K+ E L+ RE I+ ++++
Sbjct: 2 NWTRGKTLGRGSTATVSAATCHESGETLAVKSAEFHRSEFLQ----REAKILSSLNS-PY 56
Query: 225 IVGFYGA------FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWF 278
++G+ G F+N +LMEY G+L +D KN +
Sbjct: 57 VIGYRGCEITREPFHNNGEATTYSLLMEYAPYGTL--------TDVATKN------GGFI 102
Query: 279 NEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD 338
+E + + + +L GL Y+++ I H DIK SN+L+ G+ KI DFG + + + +
Sbjct: 103 DEARVVKYTRQILLGLEYIHNSKGIAHCDIKGSNVLVGENGEAKIADFGCAKWVEPEITE 162
Query: 339 TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFP-LGGHHDTPEGILDLLQRI 397
GT +M+PE +G R + D+W++G +IE+ +G P +G P +L + +
Sbjct: 163 PVRGTPAFMAPEAARGERQGKESDIWAVGCTVIEMVTGSQPWIGADFTDPVSVLYRVGYL 222
Query: 398 VNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK---------YNNR 448
P S E + DF+ +C KE R + +L+ H F+ N
Sbjct: 223 GELPELPCSLTE----QAKDFLGKCLKKEATERWTASQLLNHPFLVNKEPELVTGLVTNS 278
Query: 449 DTIAKEFRHWCKKVKKRIKEDK 470
T + W + V++ + ED+
Sbjct: 279 PTSVTDQMFW-RSVEEEVSEDR 299
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 97.4 bits (241), Expect = 4e-20
Identities = 77/279 (27%), Positives = 140/279 (49%), Gaps = 36/279 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPV-----ENKEVLKNQLVRELTIMKNVSAHDNIV 226
+G+G G V + ++ A K + V +KE LK QL +E+ ++ N H NIV
Sbjct: 220 LGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLK-QLNQEINLL-NQLCHPNIV 277
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
+YG+ + T + + +EY+ GS+ K+L Y S F E +
Sbjct: 278 QYYGSELSEETLS---VYLEYVSGGSIHKLLKDYGS---------------FTEPVIQNY 319
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVS--TTLINSLADTFVGTS 344
+ +L GL YL+ +HRDIK +NIL++ G++K+ DFG++ T +++ +F G+
Sbjct: 320 TRQILAGLAYLHG-RNTVHRDIKGANILVDPNGEIKLADFGMAKHVTAFSTML-SFKGSP 377
Query: 345 TYMSPERIQG-GRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
+M+PE + YT D+WSLG I+E+++ + P EG+ + + ++ P
Sbjct: 378 YWMAPEVVMSQNGYTHAVDIWSLGCTILEMATSKPPWSQF----EGVAAIFKIGNSKDTP 433
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
++ +H S + +F+ C + R + +L+ H F+
Sbjct: 434 EIP--DHLSNDAKNFIRLCLQRNPTVRPTASQLLEHPFL 470
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 97.1 bits (240), Expect = 6e-20
Identities = 86/331 (25%), Positives = 148/331 (43%), Gaps = 31/331 (9%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAH 222
+++ + L IG G+ G + H +++ A K I + K Q R+ ++ H
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLP-KSFSNTQNSRKEAVLLAKMKH 59
Query: 223 DNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMP 282
NIV F +F + I+MEY D G L + + + +++ ++ WF +M
Sbjct: 60 PNIVAFKESF---EAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILN----WFTQMC 112
Query: 283 LSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD--TF 340
L G+ +++ +++HRDIK NI + G VK+ DFG + L N +A T+
Sbjct: 113 L---------GVNHIHK-KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTY 162
Query: 341 VGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
VGT Y+ PE + Y K D+WSLG ++ EL + + P + IL + Q ++
Sbjct: 163 VGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQA-NSWKNLILKVCQGCIS- 220
Query: 401 PAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCK 460
P P HYS E+ V + + R S L+ + + + + + +
Sbjct: 221 PLP-----SHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGE 275
Query: 461 KVKKRIKEDKMIRREETERSKIEKRQLEKAA 491
+V + IK K T R K E+ Q K +
Sbjct: 276 EVLEEIKNSK----HNTPRKKQEEEQDRKGS 302
>7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 326
Score = 97.1 bits (240), Expect = 6e-20
Identities = 78/318 (24%), Positives = 147/318 (45%), Gaps = 40/318 (12%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
+I G + V + + + RI+A K + + + + E +++ H N+ FYG
Sbjct: 21 EIAQGVNAKVFRAKELDNDRIVALKIQHYDEEHQVS--IEEEYRTLRDYCDHPNLPEFYG 78
Query: 231 AFY--NPSTTNEIVILMEYMDCGS----LDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
+ P+ +EI +MEY G+ ++K+L + R ++++ + + + L+
Sbjct: 79 VYKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRR-MREEHIAYIIRETCRAAIELN 137
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVG 342
R ++HRDI+ NIL+ G VK+CDFG+S + ++L T +G
Sbjct: 138 R---------------NHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIG 182
Query: 343 TSTYMSPERIQGGR-----YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRI 397
+ +M+PE + T + DVW+LG+ IEL+ G+ P H T + +I
Sbjct: 183 SPCWMAPEVVSAMESREPDITVRADVWALGITTIELADGKPPFADMHPT-----RAMFQI 237
Query: 398 VNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK-YNNRDTIAK--- 453
+ P P L + ++S ++ DF++ K R + E++ H F+ + N D +
Sbjct: 238 IRNPPPTLMRPTNWSQQINDFISESLEKNAENRPMMVEMVEHPFLTELIENEDEMRSDIA 297
Query: 454 EFRHWCKKVKKRIKEDKM 471
E + VK KE ++
Sbjct: 298 EMLELSRDVKTLYKEPEL 315
>At4g32830 [D] KOG0580 Serine/threonine protein kinase
Length = 294
Score = 96.3 bits (238), Expect = 1e-19
Identities = 77/276 (27%), Positives = 126/276 (44%), Gaps = 35/276 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTI---PVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+G G G V + ++A K + ++ +V ++QL RE+ I ++ H NI+
Sbjct: 37 LGRGKFGHVYLAREKRSNHVVALKVLFKSQLQQSQV-EHQLRREVEIQSHLR-HPNILRL 94
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG FY+ + +++EY G L K L K +F+E +
Sbjct: 95 YGYFYDQK---RVYLILEYAARGELYKDLQ---------------KCKYFSERRAATYVA 136
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMS 348
+ LIY + + +IHRDIKP N+LI ++G++KI DFG S N T GT Y+
Sbjct: 137 SLARALIYCHGKH-VIHRDIKPENLLIGAQGELKIADFGWSVHTFNR-RRTMCGTLDYLP 194
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGG--HHDTPEGILDLLQRIVNEPAPKLS 406
PE ++ + D+WSLG++ E G P H DT I+ + + +P
Sbjct: 195 PEMVESVEHDASVDIWSLGILCYEFLYGVPPFEAMEHSDTYRRIVQVDLKFPPKPI---- 250
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
S D +++ +KE R L +L+ H +I
Sbjct: 251 ----ISASAKDLISQMLVKESSQRLPLHKLLEHPWI 282
>Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 445
Score = 95.9 bits (237), Expect = 1e-19
Identities = 82/330 (24%), Positives = 158/330 (47%), Gaps = 38/330 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENK-EVLKNQLVRELTIMKNVSAHDNIVG 227
L IG G+ G K D +I+ K + + E K LV E+ +++ + H NIV
Sbjct: 11 LYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK-HPNIVR 69
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+Y + + T + I+MEY + G L +++ + + +E + R+
Sbjct: 70 YYDRIIDRTNTT-LYIVMEYCEGGDLASVITKGTKE-----------RQYLDEEFVLRV- 116
Query: 288 FCVLNGLIYLYDCYK-------IIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SLAD 338
+ + L +C++ ++HRD+KP+N+ ++ K +VK+ DFG++ L + S A
Sbjct: 117 --MTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAK 174
Query: 339 TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
TFVGT YMSPE++ Y K D+WSLG ++ EL + P T +L +I
Sbjct: 175 TFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPF-----TAFSQKELAGKIR 229
Query: 399 NEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHW 458
++ YS E+ + + R ++ R S++E++ + I D +A E R
Sbjct: 230 EGKFRRIP--YRYSDELNEIITRMLNLKDYHRPSVEEILENPLIA-----DLVADEQRRN 282
Query: 459 CKKVKKRIKEDKMIRREETERSKIEKRQLE 488
++ +++ E + + S+++ ++++
Sbjct: 283 LERRGRQLGEPEKSQDSSPVLSELKLKEIQ 312
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 95.5 bits (236), Expect = 2e-19
Identities = 89/287 (31%), Positives = 129/287 (44%), Gaps = 39/287 (13%)
Query: 168 RLSKI-GAGNSGTVVKTLHVPDSRIIAKKTI------PVENKEVLKNQLVRELTIMKNVS 220
RL K+ G G G V V R +A K + P +KEV N L E+ ++KN
Sbjct: 356 RLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEV--NALECEIQLLKNF- 412
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
H+ IV +YG +P + I MEYM GS+ L Y + E
Sbjct: 413 LHERIVQYYGCLRDPQEKT-LSIFMEYMPGGSIKDQLKAYGA---------------LTE 456
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVS-----TTLINS 335
+ + +L G+ YL+ I+HRDIK +NIL +S G+VK+ DFG S L +
Sbjct: 457 NGTRKYTRQILEGVHYLHS-NMILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGT 515
Query: 336 LADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQ 395
+ GT +MSPE I G Y K D+WS+ ++E+ + E P + I +
Sbjct: 516 GMKSVTGTPYWMSPEVISGQGYGRKADIWSVACTVVEMLT-EKPPWAEFEAMAAIFKIAT 574
Query: 396 RIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+ N P H S DF+ R + E + R S EL+ H F+
Sbjct: 575 QPTNPKLP-----PHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV 615
>At2g25880 [D] KOG0580 Serine/threonine protein kinase
Length = 282
Score = 95.1 bits (235), Expect = 2e-19
Identities = 77/276 (27%), Positives = 127/276 (45%), Gaps = 35/276 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTI---PVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+G G G V I+A K + ++ +V ++QL RE+ I ++ H NI+
Sbjct: 25 LGRGKFGHVYLAREKRSDHIVALKVLFKAQLQQSQV-EHQLRREVEIQSHLR-HPNILRL 82
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG FY+ + +++EY G L K L K +F+E +
Sbjct: 83 YGYFYDQK---RVYLILEYAVRGELYKELQ---------------KCKYFSERRAATYVA 124
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMS 348
+ LIY + + +IHRDIKP N+LI ++G++KI DFG S N T GT Y+
Sbjct: 125 SLARALIYCHGKH-VIHRDIKPENLLIGAQGELKIADFGWSVHTFNR-RRTMCGTLDYLP 182
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSG--EFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
PE ++ + D+WSLG++ E G F H +T + I+ + + +P
Sbjct: 183 PEMVESVEHDASVDIWSLGILCYEFLYGVPPFEAREHSETYKRIVQVDLKFPPKPI---- 238
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
S D +++ +KE R +L +L+ H +I
Sbjct: 239 ----VSSSAKDLISQMLVKESTQRLALHKLLEHPWI 270
>7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 735
Score = 95.1 bits (235), Expect = 2e-19
Identities = 77/294 (26%), Positives = 139/294 (47%), Gaps = 38/294 (12%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLK-NQLVRELTIMKNVSA 221
L++ L+ +G G+ GT K + A K + + + K + LV E+++++ +
Sbjct: 16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQ- 74
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H NIV +Y N + + I+ME G L +I+ RS R F E
Sbjct: 75 HPNIVQYYHHLVNREAKS-VYIVMECCAGGDLAQIVQRARSQRQR-----------FEEP 122
Query: 282 PLSRISFCVLNGLIYLYDCYK---IIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SL 336
+ R+ F + L ++ I+HRDIKP+NI +++ G+ K+ DFG++ L S
Sbjct: 123 YIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSF 182
Query: 337 ADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQR 396
A +FVGT YMSPE ++G +Y K DVW++G ++ E+ + P G R
Sbjct: 183 AASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRG-------------R 229
Query: 397 IVNEPAPKLSKNEH------YSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
++ + K+++ E YS ++ + + + R ++ +I H + +
Sbjct: 230 AFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHPLVVR 283
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 94.7 bits (234), Expect = 3e-19
Identities = 67/224 (29%), Positives = 109/224 (47%), Gaps = 22/224 (9%)
Query: 158 ENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTI--PVENKEVLKNQLVRELTI 215
+ + LE+ +G G G V I+A K + K +++QL RE+ I
Sbjct: 124 KEAVALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEI 183
Query: 216 MKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKT 275
++ H NI+ YG F++ + + +++EY G++ + L K
Sbjct: 184 QSHLR-HPNILRLYGYFHDAT---RVYLILEYAPLGTVYRELQ---------------KL 224
Query: 276 SWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS 335
S F+E + + + N L Y + ++IHRDIKP N+L+ S G++KI DFG S +S
Sbjct: 225 SKFDEQRTANLYNRIANALSYCHS-KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSS 283
Query: 336 LADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFP 379
T GT Y+ PE I+G + K D+WSLG++ E G+ P
Sbjct: 284 RRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPP 327
>CE29073 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 700
Score = 94.7 bits (234), Expect = 3e-19
Identities = 74/266 (27%), Positives = 131/266 (48%), Gaps = 35/266 (13%)
Query: 146 LTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVL 205
LT + R SL+ +LE +L K+G G TV + + ++ +A K I +E +E
Sbjct: 341 LTRKNRRASLSEIGFGKLETYEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQEEGA 400
Query: 206 KNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCH 265
+RE+++++N+ H N+V + + T + ++ EY+D + L Y C+
Sbjct: 401 PCTAIREVSLLRNLR-HANVVTLHDIIH---TDRLLTLVFEYVD-----RDLKQYMDSCN 451
Query: 266 RKNVSISCKTSWFNEMPLSRIS---FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVK 322
N M ++ I + +L GL Y + +++HRD+KP N+LI +KG++K
Sbjct: 452 -------------NAMQMNNIRLFLYQLLRGLAYCHQ-RRVLHRDLKPQNLLITAKGELK 497
Query: 323 ICDFGV--STTLINSLADTFVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGE-- 377
+ DFG+ + ++ V T Y P+ + G Y+T D+W +G ++ E+ +G
Sbjct: 498 LADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILFEMIAGRAL 557
Query: 378 FPLGGHHDTPEGILDLLQRIVNEPAP 403
FP G TP L L+ R + P P
Sbjct: 558 FPGG----TPTEQLGLIFRTLGSPRP 579
>CE06779 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 577
Score = 94.7 bits (234), Expect = 3e-19
Identities = 74/266 (27%), Positives = 131/266 (48%), Gaps = 35/266 (13%)
Query: 146 LTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVL 205
LT + R SL+ +LE +L K+G G TV + + ++ +A K I +E +E
Sbjct: 218 LTRKNRRASLSEIGFGKLETYEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQEEGA 277
Query: 206 KNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCH 265
+RE+++++N+ H N+V + + T + ++ EY+D + L Y C+
Sbjct: 278 PCTAIREVSLLRNLR-HANVVTLHDIIH---TDRLLTLVFEYVD-----RDLKQYMDSCN 328
Query: 266 RKNVSISCKTSWFNEMPLSRIS---FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVK 322
N M ++ I + +L GL Y + +++HRD+KP N+LI +KG++K
Sbjct: 329 -------------NAMQMNNIRLFLYQLLRGLAYCHQ-RRVLHRDLKPQNLLITAKGELK 374
Query: 323 ICDFGV--STTLINSLADTFVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGE-- 377
+ DFG+ + ++ V T Y P+ + G Y+T D+W +G ++ E+ +G
Sbjct: 375 LADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILFEMIAGRAL 434
Query: 378 FPLGGHHDTPEGILDLLQRIVNEPAP 403
FP G TP L L+ R + P P
Sbjct: 435 FPGG----TPTEQLGLIFRTLGSPRP 456
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 94.4 bits (233), Expect = 4e-19
Identities = 78/301 (25%), Positives = 140/301 (45%), Gaps = 49/301 (16%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN---QLVRELTIMKNVSAHDNIVGF 228
+ +G G V +++ ++A K I +++ ++ Q+ E+T+++ ++ H N+V +
Sbjct: 1043 VRSGMFGDVYTGVNMETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLN-HPNVVTY 1101
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG + ++ I ME+ GSL +L+ R + +E L
Sbjct: 1102 YGVEVH---REKVYIFMEFCQGGSLADLLAHGRIE---------------DENVLKVYVV 1143
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFV------- 341
+L GL Y++ + I+HRDIKP+NIL++ +G +K DFG S ++ D V
Sbjct: 1144 QLLEGLAYIHSQH-ILHRDIKPANILLDHRGMIKYSDFG-SALYVSPPTDPEVRYEDIQP 1201
Query: 342 ------GTSTYMSPERIQGGRYTTKG-----DVWSLGLMIIELSSGEFPLGGHHDTPEGI 390
GT YM+PE I G T KG D+WSLG +I+E+ +G P +
Sbjct: 1202 ELQHLAGTPMYMAPEIILG---TKKGDFGAMDIWSLGCVILEMMTGSTP----WSEMDNE 1254
Query: 391 LDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDT 450
++ + P + +NE S DF+ +C ++ R +L+ H +I + +
Sbjct: 1255 WAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQRPRAVDLLTHPWITDFRKKTI 1314
Query: 451 I 451
I
Sbjct: 1315 I 1315
>Hs4759178 [D] KOG0580 Serine/threonine protein kinase
Length = 344
Score = 94.4 bits (233), Expect = 4e-19
Identities = 75/254 (29%), Positives = 118/254 (45%), Gaps = 40/254 (15%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--KEVLKNQLVRELTIMKNVSAHDNIVGFY 229
+G G G V I+A K + KE +++QL RE+ I ++ H NI+ Y
Sbjct: 83 LGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLH-HPNILRLY 141
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
FY+ I +++EY G L K L K+ F+E + I
Sbjct: 142 NYFYD---RRRIYLILEYAPRGELYKELQ---------------KSCTFDEQRTATIMEE 183
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
+ + L+Y + K+IHRDIKP N+L+ KG++KI DFG S + T GT Y+ P
Sbjct: 184 LADALMYCHG-KKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPP 242
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGE--FPLGGHHDT---------------PEGILD 392
E I+G + K D+W +G++ EL G F H++T P G D
Sbjct: 243 EMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQD 302
Query: 393 LLQRIV-NEPAPKL 405
L+ +++ + P+ +L
Sbjct: 303 LISKLLRHNPSERL 316
>Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1191
Score = 94.4 bits (233), Expect = 4e-19
Identities = 65/196 (33%), Positives = 103/196 (52%), Gaps = 19/196 (9%)
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTYM 347
+L GL +L+ +K+IHRDIK N+L+ +VK+ DFGVS L ++ +TF+GT +M
Sbjct: 33 ILRGLAHLH-AHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 91
Query: 348 SPERI-----QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
+PE I Y + D+WSLG+ IE++ G PL H P L L+ R P
Sbjct: 92 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMH--PMRALFLIPR---NPP 146
Query: 403 PKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKV 462
P+L K++ +S + DF++ C IK R ++L+ FI + + + +
Sbjct: 147 PRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRS 205
Query: 463 KKRIKEDKMIRREETE 478
+K+ E +EETE
Sbjct: 206 RKKRGE-----KEETE 216
>Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 493
Score = 94.0 bits (232), Expect = 5e-19
Identities = 84/359 (23%), Positives = 153/359 (42%), Gaps = 47/359 (13%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIA-KKTIPVENKEVLKNQLVRELTIMKNVSA 221
+E L +G G+ G V+K + RI+A KK + ++ +++K +RE+ ++K +
Sbjct: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR- 59
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H+N+V ++ E++D LD + + +
Sbjct: 60 HENLVNLLEVC---KKKKRWYLVFEFVDHTILD---------------DLELFPNGLDYQ 101
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADT 339
+ + F ++NG+ + + + IIHRDIKP NIL++ G VK+CDFG + TL +
Sbjct: 102 VVQKYLFQIINGIGFCHS-HNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTD 160
Query: 340 FVGTSTYMSPERIQGG-RYTTKGDVWSLGLMIIELSSGE--FPLGGHHDTPEGILDLLQR 396
+V T Y +PE + G +Y DVW++G ++ E+ GE FP D I+ L
Sbjct: 161 YVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN 220
Query: 397 IVNEPAPKLSKNEHY---------------------SIEMTDFVNRCCIKEERGRSSLKE 435
++ +KN + S + D +C + R E
Sbjct: 221 LIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAE 280
Query: 436 LICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMIRREETERSKIEKRQLEKAALAV 494
L+ HDF + ++E + +K + + K + + E+ K + E+ L V
Sbjct: 281 LLHHDFFQMDGFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVV 339
>Hs13899225 [R] KOG0586 Serine/threonine protein kinase
Length = 688
Score = 93.6 bits (231), Expect = 6e-19
Identities = 72/231 (31%), Positives = 108/231 (46%), Gaps = 23/231 (9%)
Query: 157 PENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQ-LVRELTI 215
PE + N L IG GNS V H+ R +A K I Q L RE+ I
Sbjct: 50 PEEQPHVGNYRLLRTIGKGNSAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRI 109
Query: 216 MKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKT 275
MK ++ H NIV + T + ++MEY G ++ S K K
Sbjct: 110 MKGLN-HPNIVKLFEVI---ETEKTLYLVMEYASAG---EVFDYLVSHGRMKEKEARAK- 161
Query: 276 SWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-IN 334
F ++ +S + +C I+HRD+K N+L++++ ++KI DFG S +
Sbjct: 162 --FRQI-VSAVHYCHQKN---------IVHRDLKAENLLLDAEANIKIADFGFSNEFTLG 209
Query: 335 SLADTFVGTSTYMSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHH 384
S DTF G+ Y +PE QG +Y + D+WSLG+++ L SG P GH+
Sbjct: 210 SKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHN 260
>CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 336
Score = 93.2 bits (230), Expect = 8e-19
Identities = 68/232 (29%), Positives = 113/232 (48%), Gaps = 28/232 (12%)
Query: 216 MKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKT 275
M ++ HD+I+ AF ST N+ I+ E+ G L + + RKN I
Sbjct: 123 MLSLIQHDHIISIIDAF---STENQYFIVFEHAQYGDLYETI--------RKNGRIE--- 168
Query: 276 SWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS 335
E + I+ V + L YL++ ++HRD+KP N+L+ K VK+CDFG++ ++
Sbjct: 169 ----EPDAAIITLQVASALNYLHE-RNVVHRDVKPENLLLVDKFSVKLCDFGLACHILGP 223
Query: 336 LADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQ 395
L GT TY +PE ++ Y+T+ D+WSLG+++ + G P T L
Sbjct: 224 LY-RICGTPTYCAPEVLRETGYSTRCDIWSLGVVLYVMLVGYAPFRAPDQT------RLF 276
Query: 396 RIVNEPAPKLSKNE--HYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKY 445
+++ + P L E S++ D V+R K E R +++ H +I Y
Sbjct: 277 KLIMQAKPNLDMPEWKGISLKAKDLVSRLMNKTEERRPLASQIMAHPWIAPY 328
>Hs22065797 [T] KOG0577 Serine/threonine protein kinase
Length = 897
Score = 92.8 bits (229), Expect = 1e-18
Identities = 62/168 (36%), Positives = 94/168 (55%), Gaps = 12/168 (7%)
Query: 280 EMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT 339
E+ ++ I+ L GL YL+ + +IHRDIK NIL+ G VK+ DFG ++ + S A++
Sbjct: 21 EVEIAAITHGALQGLAYLHS-HTMIHRDIKAGNILLTEPGQVKLADFGSAS--MASPANS 77
Query: 340 FVGTSTYMSPERI---QGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQR 396
FVGT +M+PE I G+Y K DVWSLG+ IEL+ + PL + + L
Sbjct: 78 FVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMN-----AMSALYH 132
Query: 397 IVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK 444
I +P L NE +S +FV+ C K + R + +EL+ H F+ +
Sbjct: 133 IAQNESPTLQSNE-WSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLR 179
>Hs16160923 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 472
Score = 92.8 bits (229), Expect = 1e-18
Identities = 76/270 (28%), Positives = 128/270 (47%), Gaps = 25/270 (9%)
Query: 135 MMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAK 194
+ + D L+ R SL+ +LE V+L K+G G TV K ++A
Sbjct: 111 LQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVAL 170
Query: 195 KTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLD 254
K I +E++E +RE++++KN+ H NIV + + T + ++ EY+D L
Sbjct: 171 KEIRLEHEEGAPCTAIREVSLLKNLK-HANIVTLHDLIH---TDRSLTLVFEYLD-SDLK 225
Query: 255 KILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNIL 314
+ L + NV I F +L GL Y + KI+HRD+KP N+L
Sbjct: 226 QYLDHCGNLMSMHNVKI--------------FMFQLLRGLAYCHH-RKILHRDLKPQNLL 270
Query: 315 INSKGDVKICDFGV--STTLINSLADTFVGTSTYMSPERIQGG-RYTTKGDVWSLGLMII 371
IN +G++K+ DFG+ + ++ V T Y P+ + G Y+T D+W +G +
Sbjct: 271 INERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHY 330
Query: 372 ELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
E+++G G T + L L+ R++ P
Sbjct: 331 EMATGRPLFPG--STVKEELHLIFRLLGTP 358
>YGR040w [T] KOG0660 Mitogen-activated protein kinase
Length = 368
Score = 92.4 bits (228), Expect = 1e-18
Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 27/237 (11%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG G GTV +H P +A K I +K++ + +RE+ +++ H+NI+
Sbjct: 19 IGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREIKLLRYFHEHENIISILDK 78
Query: 232 FYNPSTT--NEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
S N + ++ E M+ L K+++ S S ++ + ++
Sbjct: 79 VRPVSIDKLNAVYLVEELMET-DLQKVINNQNSGF-----------STLSDDHVQYFTYQ 126
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS---------LADTF 340
+L L ++ ++IHRDIKPSN+L+NS D+K+CDFG++ L +S +
Sbjct: 127 ILRALKSIHSA-QVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVGFMTEY 185
Query: 341 VGTSTYMSPE-RIQGGRYTTKGDVWSLGLMIIELSSGE--FPLGGHHDTPEGILDLL 394
V T Y +PE + YTT D+WS G ++ E+ SG+ FP +H IL++L
Sbjct: 186 VATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVL 242
>Hs4507273 [D] KOG0580 Serine/threonine protein kinase
Length = 275
Score = 92.4 bits (228), Expect = 1e-18
Identities = 72/224 (32%), Positives = 104/224 (46%), Gaps = 24/224 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--KEVLKNQLVRELTIMKNVSAHDNIVGFY 229
+G G G V I+A K + KE L++QL RE+ I ++ H NI+ Y
Sbjct: 15 LGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ-HPNILRLY 73
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
F++ + +++EY G L K L K+ +E + I
Sbjct: 74 NYFHD---ARRVYLILEYAPRGELYKELQ---------------KSEKLDEQRTATIIEE 115
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
V + L Y +D K+IHRDIKP N+L+ +G+VKI DFG S T GT Y+ P
Sbjct: 116 VADALTYCHD-KKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPLPERKTMCGTLDYLPP 174
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSG--EFPLGGHHDTPEGIL 391
E I+G Y K D+W +G++ EL G F H +T IL
Sbjct: 175 EMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRIL 218
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 92.4 bits (228), Expect = 1e-18
Identities = 88/287 (30%), Positives = 128/287 (43%), Gaps = 39/287 (13%)
Query: 168 RLSKI-GAGNSGTVVKTLHVPDSRIIAKKTI------PVENKEVLKNQLVRELTIMKNVS 220
RL K+ G G G V V R +A K + P +KEV N L E+ ++KN+
Sbjct: 358 RLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEV--NALECEIQLLKNL- 414
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
H+ IV +YG +P + I MEYM GS+ L Y + E
Sbjct: 415 LHERIVQYYGCLRDPQEKT-LSIFMEYMPGGSIKDQLKAYGA---------------LTE 458
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLAD-- 338
+ + +L G+ YL+ I+ RDIK +NIL +S G+VK+ DFG S L
Sbjct: 459 NVTRKYTRQILEGVHYLHS-NMIVLRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGT 517
Query: 339 ---TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQ 395
+ GT +MSPE I G Y K D+WS+ ++E+ + E P + I +
Sbjct: 518 GMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLT-EKPPWAEFEAMAAIFKIAT 576
Query: 396 RIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+ N P H S DF+ R + E + R S EL+ H F+
Sbjct: 577 QPTNPKLP-----PHVSDYTRDFLKRIFV-EAKLRPSADELLRHMFV 617
>7299536 [D] KOG0580 Serine/threonine protein kinase
Length = 411
Score = 92.4 bits (228), Expect = 1e-18
Identities = 81/313 (25%), Positives = 138/313 (43%), Gaps = 33/313 (10%)
Query: 132 GVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRI 191
G + E ++T T T N + L+ K G ++ V ++
Sbjct: 125 GAASSSAEKEKTKTETQPQKPKKTWELNNFDIGRLLGRGKFGNVYLAREKESQFVVALKV 184
Query: 192 IAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCG 251
+ K+ I N E +Q+ RE+ I ++ H +I+ Y F++ I +++EY G
Sbjct: 185 LFKRQIGESNVE---HQVRREIEIQSHLR-HPHILRLYAYFHDDV---RIYLILEYAPQG 237
Query: 252 SLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPS 311
+L L F+E + + + L+YL++ IIHRDIKP
Sbjct: 238 TLFNALQAQ-------------PMKRFDERQSATYIQALCSALLYLHE-RDIIHRDIKPE 283
Query: 312 NILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMII 371
N+L+ KG +KI DFG S NS+ T GT Y+ PE +QG +T D+WSLG++
Sbjct: 284 NLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCF 343
Query: 372 ELSSGEFPL--GGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERG 429
EL G P + +T + IL + ++ EH S + +++ + +
Sbjct: 344 ELLVGHAPFYSKNYDETYKKILKVDYKL----------PEHISKAASHLISKLLVLNPQH 393
Query: 430 RSSLKELICHDFI 442
R L +++ H +I
Sbjct: 394 RLPLDQVMVHPWI 406
>At5g37790 [T] KOG1187 Serine/threonine protein kinase
Length = 552
Score = 92.0 bits (227), Expect = 2e-18
Identities = 76/264 (28%), Positives = 131/264 (48%), Gaps = 28/264 (10%)
Query: 192 IAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCG 251
+A K + E+KE K+ REL I ++ + NIV G +P + ++ +Y+ G
Sbjct: 237 LAIKRLDKEDKESPKS-FCRELMIASSLHS-SNIVPLLGFCIDPE--EGLFLVYKYVSGG 292
Query: 252 SLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYK--IIHRDIK 309
SL+ L + +K V + W +++ + + + YL++ + ++HRDIK
Sbjct: 293 SLEHYLHDKKK---KKGVKAAFGLPWSARY---KVALGIADAIAYLHNGTEQCVVHRDIK 346
Query: 310 PSNILINSKGDVKICDFGVST----TLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWS 365
PSNIL++SK K+CDFG++T + L T GT Y++PE Q G+ + K DV++
Sbjct: 347 PSNILLSSKKIPKLCDFGLATWTAAPSVPFLCKTVKGTFGYLAPEYFQHGKISDKTDVYA 406
Query: 366 LGLMIIELSSGEFPL-----GGHHDTPEGILDLLQR----IVNEPAPKLSKNEHYSIEMT 416
G++++EL +G P+ G + LL R IV P+L S++M
Sbjct: 407 FGVVLLELITGRKPIEARRASGQENLVVWAKPLLDRGIEAIVELLDPRLKCTRKNSVQME 466
Query: 417 DFVN---RCCIKEERGRSSLKELI 437
+ C I EE R ++E++
Sbjct: 467 RMIRAAAACVINEESRRPGMEEIV 490
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 92.0 bits (227), Expect = 2e-18
Identities = 72/277 (25%), Positives = 136/277 (48%), Gaps = 32/277 (11%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN----QLVRELTIMKNVSAHDNIVG 227
+G G+ G V + + A K + + + + QL +E++++ + H NIV
Sbjct: 406 LGMGSFGHVYLGFNSESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLR-HQNIVQ 464
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+YG+ + +++ I +EY+ GS+ K+L Y F E + +
Sbjct: 465 YYGS---ETVDDKLYIYLEYVSGGSIYKLLQEYGQ---------------FGENAIRNYT 506
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-INSLADTFVGTSTY 346
+L+GL YL+ +HRDIK +NIL++ G VK+ DFG++ + S +F G+ +
Sbjct: 507 QQILSGLAYLH-AKNTVHRDIKGANILVDPHGRVKVADFGMAKHITAQSGPLSFKGSPYW 565
Query: 347 MSPERIQGGRYTTKG-DVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
M+PE I+ + D+WSLG ++E+++ + P + EG+ + + ++ P +
Sbjct: 566 MAPEVIKNSNGSNLAVDIWSLGCTVLEMATTKPPWSQY----EGVPAMFKIGNSKELPDI 621
Query: 406 SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+H S E DFV +C + R + +L+ H F+
Sbjct: 622 P--DHLSEEGKDFVRKCLQRNPANRPTAAQLLDHAFV 656
>7301213 [R] KOG0589 Serine/threonine protein kinase
Length = 841
Score = 92.0 bits (227), Expect = 2e-18
Identities = 64/230 (27%), Positives = 110/230 (47%), Gaps = 22/230 (9%)
Query: 150 IARLSLTPENGI-----QLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEV 204
+ +LS+ E G+ +L N ++ +G G+ G + D I K I +
Sbjct: 84 LLQLSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSP 143
Query: 205 LKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDC 264
L + + H NIV + G+F +T ++I MEY D G+L +I++ +
Sbjct: 144 PGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNT---LLIEMEYADGGTLAQIIAERQGKL 200
Query: 265 HRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKIC 324
H F E + + + + + Y++ I+HRD+K +N+ +N +G VKI
Sbjct: 201 H------------FPERYIIAVFEQISSAINYMHS-ENILHRDLKTANVFLNRRGIVKIG 247
Query: 325 DFGVSTTLINSL-ADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIEL 373
DFG+S + + A T +GT Y SPE +G Y K D+W+LG ++ E+
Sbjct: 248 DFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEM 297
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 91.7 bits (226), Expect = 2e-18
Identities = 78/291 (26%), Positives = 137/291 (46%), Gaps = 50/291 (17%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTI---PVENKEVLKNQLVRELTIMKNVSAHDN 224
R +KIG G G V + V ++A K I P ++K + + EL I + + H N
Sbjct: 1295 RGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTI--KETADELKIFEGIK-HPN 1351
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKI----LSVYRSDCHRKNVSISCKTSWFNE 280
+V ++G + E+ I MEY D G+L+++ L + + K ++I+
Sbjct: 1352 LVRYFGVELH---REEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIA-------- 1400
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL---- 336
I + + I+HRDIK +NI + S G +K+ DFG S L N+
Sbjct: 1401 --------------INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMP 1446
Query: 337 --ADTFVGTSTYMSPE---RIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGIL 391
++ +GT+ YM+PE R +G + D+WSLG ++IE+ +G+ P + E
Sbjct: 1447 GEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY----EHNF 1502
Query: 392 DLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
++ ++ P + E S E DF++ C + + R + +L+ H F+
Sbjct: 1503 QIMYKVGMGHKPPIP--ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1551
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 91.7 bits (226), Expect = 2e-18
Identities = 78/291 (26%), Positives = 137/291 (46%), Gaps = 50/291 (17%)
Query: 168 RLSKIGAGNSGTVVKTLHVPDSRIIAKKTI---PVENKEVLKNQLVRELTIMKNVSAHDN 224
R +KIG G G V + V ++A K I P ++K + + EL I + + H N
Sbjct: 1344 RGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTI--KETADELKIFEGIK-HPN 1400
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKI----LSVYRSDCHRKNVSISCKTSWFNE 280
+V ++G + E+ I MEY D G+L+++ L + + K ++I+
Sbjct: 1401 LVRYFGVELH---REEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIA-------- 1449
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSL---- 336
I + + I+HRDIK +NI + S G +K+ DFG S L N+
Sbjct: 1450 --------------INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMP 1495
Query: 337 --ADTFVGTSTYMSPE---RIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGIL 391
++ +GT+ YM+PE R +G + D+WSLG ++IE+ +G+ P + E
Sbjct: 1496 GEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY----EHNF 1551
Query: 392 DLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
++ ++ P + E S E DF++ C + + R + +L+ H F+
Sbjct: 1552 QIMYKVGMGHKPPIP--ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1600
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 91.7 bits (226), Expect = 2e-18
Identities = 65/210 (30%), Positives = 103/210 (48%), Gaps = 22/210 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTI--PVENKEVLKNQLVRELTIMKNVSAHDNIVGFY 229
+G G G V I+A K + K +++QL RE+ I ++ H NI+ Y
Sbjct: 139 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLR-HPNILRLY 197
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
G F++ + + +++EY G++ + L K S F+E +
Sbjct: 198 GYFHDAT---RVYLILEYAPLGTVYRELQ---------------KLSKFDEQRTATYITE 239
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
+ N L Y + ++IHRDIKP N+L+ S G++KI DFG S +S T GT Y+ P
Sbjct: 240 LANALSYCHS-KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPP 298
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFP 379
E I+G + K D+WSLG++ E G+ P
Sbjct: 299 EMIEGRMHDEKVDLWSLGVLCYEFLVGKPP 328
>At1g66460 [T] KOG1187 Serine/threonine protein kinase
Length = 467
Score = 91.7 bits (226), Expect = 2e-18
Identities = 78/269 (28%), Positives = 136/269 (49%), Gaps = 34/269 (12%)
Query: 190 RIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMD 249
+ +A K + ++KE K+ REL I ++++ N+V G +P + ++ +Y+
Sbjct: 153 KAVAIKRLDKKDKESPKS-FCRELMIASSLNS-PNVVPLLGFCIDPD--QGLFLVYKYVS 208
Query: 250 CGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS---RISFCVLNGLIYLYDCYK--II 304
GSL++ L H K S KT +P S +++ + + + YL++ + ++
Sbjct: 209 GGSLERFL-------HDKKKKKSRKTPL--NLPWSTRYKVALGIADAIAYLHNGTEQCVV 259
Query: 305 HRDIKPSNILINSKGDVKICDFGVST----TLINSLADTFVGTSTYMSPERIQGGRYTTK 360
HRDIKPSNIL++S K+CDFG++T + L T GT Y++PE Q G+ + K
Sbjct: 260 HRDIKPSNILLSSNKIPKLCDFGLATWTAAPSVPFLCKTVKGTFGYLAPEYFQHGKISDK 319
Query: 361 GDVWSLGLMIIELSSGEFPLGGHHDTPEGIL-----DLLQRIVN------EPAPKLSKNE 409
DV++ G++++EL +G P+ + E L LL R + +P K ++
Sbjct: 320 TDVYAFGVVLLELITGRKPIEARRPSGEENLVVWAKPLLHRGIEATEELLDPRLKCTRKN 379
Query: 410 HYSIE-MTDFVNRCCIKEERGRSSLKELI 437
S+E M C I EE R +KE++
Sbjct: 380 SASMERMIRAAAACVINEESRRPGMKEIL 408
>At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 473
Score = 91.3 bits (225), Expect = 3e-18
Identities = 78/309 (25%), Positives = 149/309 (47%), Gaps = 45/309 (14%)
Query: 197 IPVENKEVLKNQL--VRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGS-L 253
I + N E N L +R+ ++ H N++ + +F + S+ + I+M +M CGS L
Sbjct: 40 IKIWNLEKCTNDLETIRKEVHRLSLIDHPNLLRVHCSFIDSSS---LWIVMPFMSCGSSL 96
Query: 254 DKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNI 313
+ + SVY + ++I + +L L+YL+ I HR++K N+
Sbjct: 97 NIMKSVYPNGLEEPVIAILLRE--------------ILKALVYLHGLGHI-HRNVKAGNV 141
Query: 314 LINSKGDVKICDFGVSTTLINSL-------ADTFVGTSTYMSPER--IQGGRYTTKGDVW 364
L++S+G VK+ DF VS ++ +S+ +TFVG M+PE+ Q Y K D+W
Sbjct: 142 LVDSEGTVKLGDFEVSASMFDSVERMRTSSENTFVGNPRRMAPEKDMQQVDGYDFKVDIW 201
Query: 365 SLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCI 424
S G+ +EL+ H +P +L L + N P P ++ +S + V C I
Sbjct: 202 SFGMTALELA--------HGHSPTTVLPL--NLQNSPFPNYEEDTKFSKSFRELVAACLI 251
Query: 425 KEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKR---IKED--KMIRREETER 479
++ R + +L+ + F+ + + + +A F + +R +KE+ K+++ + +
Sbjct: 252 EDPEKRPTASQLLEYPFLQQTLSTEYLASTFLDGLSPLGERYRKLKEEKAKLVKGVDGNK 311
Query: 480 SKIEKRQLE 488
K+ + +E
Sbjct: 312 EKVSQENVE 320
>Hs17461944 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 385
Score = 90.9 bits (224), Expect = 4e-18
Identities = 86/304 (28%), Positives = 142/304 (46%), Gaps = 33/304 (10%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIA-KKTIPVENKEVLKNQLVRELTIMKNVSA 221
+E +L+K G G+ G V K + +++A KK + E+ V+K +RE+ ++K +
Sbjct: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLK- 59
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H N+V F ++ ++ EY D L+++ R+ + SI +
Sbjct: 60 HPNLVNLIEVFRRK---RKMHLVFEYCDHTLLNEL---ERNPNGMDSDSIVGRL----RS 109
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT-F 340
R N I + C IHRDIKP NILI +G +KICDFG + LI A T +
Sbjct: 110 VADRSRLAPKNNQIMILQC---IHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDY 166
Query: 341 VGTSTYMSPERIQGG-RYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVN 399
V T Y +PE + G +Y + D+W++G + EL +G+ G D + L L+ R +
Sbjct: 167 VATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQ--LYLIIRTLG 224
Query: 400 EPAPKLSKNEHYSI-EMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHW 458
+ P+ H SI + F + I E +L+E K+++ +A F
Sbjct: 225 KLIPR-----HQSIFKSNGFFHGISIPEPEDMETLEE--------KFSDVHPVALNFMKG 271
Query: 459 CKKV 462
C K+
Sbjct: 272 CLKM 275
>Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 628
Score = 90.9 bits (224), Expect = 4e-18
Identities = 70/222 (31%), Positives = 113/222 (50%), Gaps = 31/222 (13%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQ-----LVRELTIMKNVSAHD 223
L +G G G V K R++A K+I K+ +K++ + RE+ IM +++ H
Sbjct: 56 LETLGKGTYGKVKKARE-SSGRLVAIKSI---RKDKIKDEQDLMHIRREIEIMSSLN-HP 110
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
+I+ + F N S +IVI+MEY G L +S R+ +S +F ++ +
Sbjct: 111 HIIAIHEVFENSS---KIVIVMEYASRGDLYDYIS------ERQQLSEREARHFFRQI-V 160
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-INSLADTFVG 342
S + +C N +++HRD+K NIL+++ G++KI DFG+S TF G
Sbjct: 161 SAVHYCHQN---------RVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCG 211
Query: 343 TSTYMSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGH 383
+ Y SPE + G YT + D WSLG+++ L G P GH
Sbjct: 212 SPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGH 253
>At1g29230 [T] KOG0583 Serine/threonine protein kinase
Length = 520
Score = 90.9 bits (224), Expect = 4e-18
Identities = 88/352 (25%), Positives = 161/352 (45%), Gaps = 53/352 (15%)
Query: 139 ETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIP 198
+TD+ ++ Q R +P N I + +G G V ++ +A K I
Sbjct: 47 DTDKDGNISPQSPRSPRSPRNNILMGKYELGKLLGHGTFAKVYLAQNIKSGDKVAIKVI- 105
Query: 199 VENKEVLKNQLV----RELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLD 254
+ ++++K+ LV RE++I++ V H IV + +T ++I +MEY+ G L
Sbjct: 106 -DKEKIMKSGLVAHIKREISILRRVR-HPYIVHLFEVM---ATKSKIYFVMEYVGGGELF 160
Query: 255 KILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNIL 314
++ R + +F ++ +S +SFC G + HRD+KP N+L
Sbjct: 161 NTVAKGR-------LPEETARRYFQQL-ISSVSFCHGRG---------VYHRDLKPENLL 203
Query: 315 INSKGDVKICDFGVSTTL----INSLADTFVGTSTYMSPERI-QGGRYTTKGDVWSLGLM 369
+++KG++K+ DFG+S + L TF GT Y++PE + + G K DVWS G++
Sbjct: 204 LDNKGNLKVSDFGLSAVAEQLRQDGLCHTFCGTPAYIAPEVLTRKGYDAAKADVWSCGVI 263
Query: 370 IIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERG 429
+ L +G P + I+ + ++I + +S ++ + R
Sbjct: 264 LFVLMAGHIPF-----YDKNIMVMYKKIYK---GEFRCPRWFSSDLVRLLTRLLDTNPDT 315
Query: 430 RSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMIRREETERSK 481
R ++ E++ NR K F+H VK I++DK+ R +E E +
Sbjct: 316 RITIPEIM--------KNR-WFKKGFKH----VKFYIEDDKLCREDEDEEEE 354
>CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 294
Score = 90.5 bits (223), Expect = 5e-18
Identities = 73/273 (26%), Positives = 134/273 (48%), Gaps = 26/273 (9%)
Query: 157 PENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENK--EVLKNQLVRELT 214
P + + LE + KIG G V + +A K I V + + ++E+
Sbjct: 14 PPDKLSLELFIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEID 73
Query: 215 IMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCK 274
++K ++ H N++ +Y +F + N++ I++E + G + +++ ++ + I K
Sbjct: 74 LLKQLN-HVNVIRYYASFID---NNQLNIVLELAEAGDMSRMIKHFK----KGGRLIPEK 125
Query: 275 TSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN 334
T W + L+R L +++ +I+HRDIKP+N+ I G VK+ D G+ +
Sbjct: 126 TIWKYFVQLAR-------ALAHMHS-KRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSS 177
Query: 335 --SLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILD 392
+ A + VGT YMSPERIQ Y K D+WS G ++ E+++ + P G +
Sbjct: 178 KTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYG---DKMNLYS 234
Query: 393 LLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIK 425
L ++I N P L + YS +++ N C ++
Sbjct: 235 LCKKIENCEYPPLPA-DIYSTQVS--ANLCFVQ 264
>7300559 [T] KOG4279 Serine/threonine protein kinase
Length = 1310
Score = 90.5 bits (223), Expect = 5e-18
Identities = 87/283 (30%), Positives = 126/283 (43%), Gaps = 42/283 (14%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G GTV IA K +P +N + + Q + E + + H NIV + G+
Sbjct: 585 LGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDV--QPLHEEIKLHSQLRHRNIVRYLGS 642
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWF----NEMPLSRIS 287
S I ME + GSL +L +T W NE ++ S
Sbjct: 643 C---SENGFFKIFMEQVPGGSLSDLL----------------ETKWGPLKDNESTMAFYS 683
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINS-KGDVKICDFGVSTTL--INSLADTFVGTS 344
+L GL YL++ I+HRDIK N+L+N+ G VKI DFG S L IN + +TF GT
Sbjct: 684 KQILEGLKYLHE-QDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTL 742
Query: 345 TYMSPERIQGG--RYTTKGDVWSLGLMIIELSSGEFP---LGGHHDTPEGILDLLQRIVN 399
YM+PE I G Y D+WS G +E+++G+ P LG H + ++ N
Sbjct: 743 QYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKV-GFYKKHPN 801
Query: 400 EPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P E S +F+ RC R S +L+ F+
Sbjct: 802 IP-------EELSANAKNFILRCFAISVMDRPSASQLLEDPFL 837
>Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase
Length = 330
Score = 90.5 bits (223), Expect = 5e-18
Identities = 75/274 (27%), Positives = 131/274 (47%), Gaps = 28/274 (10%)
Query: 167 VRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIV 226
+R+ GA T+ + DS ++ K+ E + + E+ I+ + HDNI+
Sbjct: 55 IRVLGRGAFGEATLYRRTE-DDSLVVWKEVDLTRLSEKERRDALNEIVILALLQ-HDNII 112
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSL-DKILSVYRSDCHRKNVSISCKTSWFNEMPLSR 285
+Y F + +T ++I +EY + G+L DKIL K F E +
Sbjct: 113 AYYNHFMDNTT---LLIELEYCNGGNLYDKILRQ--------------KDKLFEEEMVVW 155
Query: 286 ISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SLADTFVGT 343
F +++ + ++ I+HRDIK NI + +K+ D+G++ L + S+A+T VGT
Sbjct: 156 YLFQIVSAVSCIHKA-GILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGT 214
Query: 344 STYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAP 403
YMSPE QG +Y K D+W++G +I EL + + + L+L +IV
Sbjct: 215 PYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNP-----LNLCVKIVQGIRA 269
Query: 404 KLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELI 437
+ YS+E+ V+ C ++ R + EL+
Sbjct: 270 MEVDSSQYSLELIQMVHSCLDQDPEQRPTADELL 303
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 90.1 bits (222), Expect = 7e-18
Identities = 70/224 (31%), Positives = 107/224 (47%), Gaps = 27/224 (12%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--KEVLKNQLVRELTIMKN 218
+ L++ K+G G G V H I A K + E K L+ Q RE+ I +
Sbjct: 99 LSLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTS 158
Query: 219 VSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWF 278
++ H N+ YG F++ + +LMEY+ G + K+L ++ F
Sbjct: 159 LN-HPNLTKSYGYFHDEK---RVYLLMEYLVNGEMYKLLRLHGP---------------F 199
Query: 279 NEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN---S 335
N++ S + + N L Y++ IIHRDIKP NILI +K+ DFG S +IN +
Sbjct: 200 NDILASDYIYQIANALDYMHK-KNIIHRDIKPENILIGFNNVIKLTDFGWS--IINPPEN 256
Query: 336 LADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFP 379
T GT Y+SPE ++ Y D W+LG++ EL +G P
Sbjct: 257 RRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPP 300
>YCL024w [T] KOG0583 Serine/threonine protein kinase
Length = 1037
Score = 90.1 bits (222), Expect = 7e-18
Identities = 75/286 (26%), Positives = 136/286 (47%), Gaps = 36/286 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVE----------NKEVLKNQLVRELTIMKNVSA 221
+G G++G V H A K I + VL + RE+ IMK +S
Sbjct: 27 LGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLS- 85
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H N++ Y + T N + +++EY + G L +L + R+ +I+C F ++
Sbjct: 86 HPNVLSLYDVW---ETNNNLYLILEYAEKGELFNLLVDHGPLPERE--AINC----FRQI 136
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS-LADTF 340
+ IS+C G I+HRD+KP N+L++S ++KI DFG++ ++ L +T
Sbjct: 137 IIG-ISYCHALG---------IVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETS 186
Query: 341 VGTSTYMSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVN 399
G+ Y +PE + G Y DVWS G+++ L +G P + + DLL + V
Sbjct: 187 CGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENG---NVRDLLLK-VQ 242
Query: 400 EPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKY 445
+ ++ + S + D + + + + R R +++++ H + KY
Sbjct: 243 KGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKY 288
>SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1116
Score = 90.1 bits (222), Expect = 7e-18
Identities = 86/298 (28%), Positives = 133/298 (43%), Gaps = 42/298 (14%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENK-----EVLKNQLVRELTIMKNVSA---HD 223
IG G G V +++ +IA K + + + L+ +V + ++ A H
Sbjct: 831 IGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAEISMIADLDHL 890
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
NIV + G T +I I +EY+ GS+ + L Y F E +
Sbjct: 891 NIVQYLGF---EKTETDISIFLEYVSGGSIGRCLRNYGP---------------FEEQLV 932
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVS----TTLINSLADT 339
+S VL GL YL+ IIHRD+K N+LI+ G KI DFG+S N +
Sbjct: 933 RFVSRQVLYGLSYLHS-KGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDANLS 991
Query: 340 FVGTSTYMSPERIQGGR--YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRI 397
G+ +M+PE I Y+ K DVWSLG +++E+ +G P T E I + +
Sbjct: 992 MQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRP----WSTDEAIQAMFKLG 1047
Query: 398 VNEPAPKLSKN--EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI-C--KYNNRDT 450
+ AP + S E F+N C R + +EL+ H F+ C ++N +DT
Sbjct: 1048 TEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFMKCDEEFNFKDT 1105
>CE27573 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1420
Score = 89.7 bits (221), Expect = 9e-18
Identities = 64/229 (27%), Positives = 111/229 (47%), Gaps = 39/229 (17%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L I +G+ G+V + + + R+IA K + ++ + + E+ I + + H+N+V +
Sbjct: 1128 LDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQREN--HKAIESEINIFRQL-IHENLVKY 1184
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG S +++I MEY G+L++I CH K + + + N +
Sbjct: 1185 YGVQVEDS---DVIIFMEYCSQGTLERI-------CHGK-MDLKMVRQYTNSL------- 1226
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA-----DTFVGT 343
L + YL+ +KIIHRDIKP+NI ++ +K+ DFG S+ L+ S T GT
Sbjct: 1227 --LRAVQYLHS-HKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGT 1283
Query: 344 STYMSPERIQGGR----------YTTKGDVWSLGLMIIELSSGEFPLGG 382
+M+PE G Y D+W+LG ++ + +G+ P G
Sbjct: 1284 PQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEG 1332
>CE07737 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1418
Score = 89.7 bits (221), Expect = 9e-18
Identities = 64/229 (27%), Positives = 111/229 (47%), Gaps = 39/229 (17%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
L I +G+ G+V + + + R+IA K + ++ + + E+ I + + H+N+V +
Sbjct: 1128 LDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQREN--HKAIESEINIFRQL-IHENLVKY 1184
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG S +++I MEY G+L++I CH K + + + N +
Sbjct: 1185 YGVQVEDS---DVIIFMEYCSQGTLERI-------CHGK-MDLKMVRQYTNSL------- 1226
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLA-----DTFVGT 343
L + YL+ +KIIHRDIKP+NI ++ +K+ DFG S+ L+ S T GT
Sbjct: 1227 --LRAVQYLHS-HKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGT 1283
Query: 344 STYMSPERIQGGR----------YTTKGDVWSLGLMIIELSSGEFPLGG 382
+M+PE G Y D+W+LG ++ + +G+ P G
Sbjct: 1284 PQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEG 1332
>7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1612
Score = 89.7 bits (221), Expect = 9e-18
Identities = 83/295 (28%), Positives = 140/295 (47%), Gaps = 40/295 (13%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEV--LKNQLVRELTIMKNVSAHDNIVGF 228
KIG G G V ++ ++A K I ++ E LKN + EL I++ + H N+V +
Sbjct: 1328 KIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKN-VAEELKILEGIK-HKNLVRY 1385
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
YG + E++I ME G+L+ ++ + T E R +
Sbjct: 1386 YGIEVH---REELLIFMELCSEGTLESLVEL---------------TGNLPEALTRRFTA 1427
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNI-LINSKGDVKICDFGVST-----TLINSLADTFVG 342
+L+G+ L+ + I+HRDIK +NI L++ +K+ DFG + T + +VG
Sbjct: 1428 QLLSGVSELHK-HGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPGELQGYVG 1486
Query: 343 TSTYMSPE---RIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVN 399
T YM+PE + + D+WS+G +++E++SG+ P D+ I+ +
Sbjct: 1487 TQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRP-WAQFDSNFQIMFKVGMGEK 1545
Query: 400 EPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKE 454
AP E S E DF++ C + + R + EL+ H+F CKY RD + E
Sbjct: 1546 PQAP-----ESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNF-CKY-GRDECSSE 1593
>7297009 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 392
Score = 89.4 bits (220), Expect = 1e-17
Identities = 94/371 (25%), Positives = 160/371 (42%), Gaps = 57/371 (15%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIA-KKTIPVENKEVLKNQLVRELTIMKNVSA 221
++ +LS++G G+ G V K ++A K+ + E+ ++ +RE+ ++KN+
Sbjct: 1 MDRYEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNLK- 59
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H N+V F + ++ E+ + L + L + C E
Sbjct: 60 HPNLVSLLEVFRRK---RRLHLVFEFCELTVLHE-LERHPQGCP--------------EH 101
Query: 282 PLSRISFCVLNGLIYLYDCYK--IIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT 339
+I + L G+ Y C+K +HRDIKP NIL+ ++G VK+CDFG + L T
Sbjct: 102 LTKQICYQTLLGVAY---CHKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGENYT 158
Query: 340 -FVGTSTYMSPERIQGG-RYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGIL------ 391
+V T Y +PE + G +Y T DVW++G + EL GE G D + L
Sbjct: 159 DYVATRWYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLG 218
Query: 392 DLLQRIV-----NE-------PAP--------KLSKNEHYSIEMTDFVNRCCIKEERGRS 431
DLL R + NE P P K+ + DF+ +C K+ R
Sbjct: 219 DLLPRHIQIFGQNEYFKGITLPVPPTLEPLEDKMPAKSQQNPLTIDFLKKCLDKDPTKRW 278
Query: 432 SLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMIRREETERSKIEKRQLEKA- 490
S ++L H + Y + +E H +++ ++ ++ + ++ Q A
Sbjct: 279 SCEKLTKHSYFDDYIAKQ---RELEHVNSLEAANLRQQQLASQQFMLATAAQQLQTGPAQ 335
Query: 491 ALAVTAARSSS 501
A A+ AAR S
Sbjct: 336 AAAIAAARDKS 346
>At2g32510 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 372
Score = 89.0 bits (219), Expect = 2e-17
Identities = 82/336 (24%), Positives = 156/336 (46%), Gaps = 46/336 (13%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G++ TV I+A K+ V E L+ RE I+ ++S+ ++G+ G+
Sbjct: 9 LGRGSTATVYAAAGHNSDEILAVKSSEVHRSEFLQ----REAKILSSLSS-PYVIGYRGS 63
Query: 232 FYNPSTTNEIV--ILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
+ ++ +LMEY G+L +D K+ +E + + +
Sbjct: 64 ETKRESNGVVMYNLLMEYAPYGTL--------TDAAAKD------GGRVDETRVVKYTRD 109
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
+L GL Y++ I+H D+K SN++I+ KG+ KI DFG + + +GT +M+P
Sbjct: 110 ILKGLEYIHS-KGIVHCDVKGSNVVISEKGEAKIADFGCAKRVDPVFESPVMGTPAFMAP 168
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRI-VNEPAPKLSKN 408
E +G + + D+W++G +IE+ +G P D+ E + +L R+ + P+L
Sbjct: 169 EVARGEKQGKESDIWAVGCTMIEMVTGS-PPWTKADSREDPVSVLYRVGYSSETPELPC- 226
Query: 409 EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICK------------YNNRDTIAKEFR 456
+ E DF+ +C +E R + +L+ H F+ +N T +
Sbjct: 227 -LLAEEAKDFLEKCLKREANERWTATQLLNHPFLTTKPDIEPVLVPGLISNSPTSVTDQT 285
Query: 457 HWCKKVKKRIKEDKMIRREETERSKIEKRQLEKAAL 492
W + ++E++ EETE + + R L++ +L
Sbjct: 286 FW-----RSVEEEE---EEETEEIQKDSRDLDRLSL 313
>CE27902 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 427
Score = 88.6 bits (218), Expect = 2e-17
Identities = 66/217 (30%), Positives = 103/217 (47%), Gaps = 33/217 (15%)
Query: 166 LVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNI 225
L R +G G TV LH + KTI +N + K + +E+ + S D +
Sbjct: 162 LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILSQNTD--KTEYEKEILAYEECSQSDYV 219
Query: 226 VGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS- 284
VG++G + S E+V+ EYMD G F +P S
Sbjct: 220 VGYHGCEVS-SIKKELVL--EYMDKGDFRP----------------------FGILPFSV 254
Query: 285 --RISFCVLNGLIYLYDCYK-IIHRDIKPSNILINSKGDVKICDFGVSTTLINS--LADT 339
++ ++ + ++++ IHRDIKP NIL+NS+G VKICDFG + + N+ +A +
Sbjct: 255 HQSVALSLIRAIRHVWNSGPGYIHRDIKPENILVNSQGYVKICDFGAAKRIDNTYRIASS 314
Query: 340 FVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSG 376
GT Y +PE+ G Y+ K D+W GL + E + G
Sbjct: 315 AAGTQMYQAPEQQMGQDYSEKVDIWCFGLTLWEFAIG 351
>Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 358
Score = 88.2 bits (217), Expect = 3e-17
Identities = 87/350 (24%), Positives = 155/350 (43%), Gaps = 55/350 (15%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIA-KKTIPVENKEVLKNQLVRELTIMKNVSA 221
+E ++ KIG G+ G V K + +I+A KK + E+ V+K +RE+ ++K +
Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK- 60
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H N+V F + ++ EY D L ++ R SI+ +T
Sbjct: 61 HPNLVNLLEVFRRK---RRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQT------ 111
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADT 339
L ++FC + ++C IHRD+KP NILI +K+CDFG + L +
Sbjct: 112 -LQAVNFC------HKHNC---IHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTD 161
Query: 340 FVGTSTYMSPERIQGG-RYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
+V T Y SPE + G +Y DVW++G + EL SG G D + L L+++ +
Sbjct: 162 YVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQ--LYLIRKTL 219
Query: 399 NEPAPK----LSKNEHYS-IEMTD--------------------FVNRCCIKEERGRSSL 433
+ P+ S N+++S +++ D + C + R +
Sbjct: 220 GDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTC 279
Query: 434 KELICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMIRREETERSKIE 483
++L+ H + + +AKE +K ++ ++ TE SK++
Sbjct: 280 EQLLHHPYFENIREIEDLAKEHDKPTRKTLRKSRKHHCF----TETSKLQ 325
>Hs4506073 [T] KOG0694 Serine/threonine protein kinase
Length = 942
Score = 88.2 bits (217), Expect = 3e-17
Identities = 77/292 (26%), Positives = 132/292 (44%), Gaps = 38/292 (13%)
Query: 120 TTRDAPMSLTPTGVSMMQQETDETATLTTQI---ARLSLTPENGIQLENLVRLSKIGAGN 176
++RD P S + + + E + T + A S ++ + LE+ L+ +G G+
Sbjct: 566 SSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGH 625
Query: 177 SGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSA------HDNIVGFYG 230
G V+ + P + A K + + +++ V L K + A H +V +G
Sbjct: 626 FGKVLLSEFRPSGELFAIKAL--KKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFG 683
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
F P + +MEY G L + + F+E S CV
Sbjct: 684 CFQTPE---HVCFVMEYSAGGDL----------------MLHIHSDVFSEPRAIFYSACV 724
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SLADTFVGTSTYMS 348
+ GL +L++ +KI++RD+K N+L++++G VKI DFG+ + TF GT +++
Sbjct: 725 VLGLQFLHE-HKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 783
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
PE + YT D W LG+++ E+ GE P G D E + D IVN+
Sbjct: 784 PEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPG--DDEEEVFD---SIVND 830
>Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 596
Score = 88.2 bits (217), Expect = 3e-17
Identities = 87/337 (25%), Positives = 157/337 (45%), Gaps = 59/337 (17%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V + +A K I + + K ++ E+ +M ++ H N++ Y A
Sbjct: 291 LGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD-KEMVLLEIEVMNQLN-HRNLIQLYAA 348
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVL 291
P +EIV+ MEY++ G L + + D H V T F +
Sbjct: 349 IETP---HEIVLFMEYIEGGELFE--RIVDEDYHLTEVD----TMVFVRQ--------IC 391
Query: 292 NGLIYLYDCYKIIHRDIKPSNIL-INSKGD-VKICDFGVSTTLI-NSLADTFVGTSTYMS 348
+G+++++ +++H D+KP NIL +N+ G VKI DFG++ N GT ++S
Sbjct: 392 DGILFMHKM-RVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLS 450
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN 408
PE + + + K D+WS+G++ L SG P G DT + L + LS N
Sbjct: 451 PEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDT-----ETLNNV-------LSGN 498
Query: 409 --------EHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCK 460
E S E DFV+ +K++R R + + + H ++ + +A++ K
Sbjct: 499 WYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL------NNLAEK----AK 548
Query: 461 KVKKRIKEDKMIRREETERSKIEKRQLEKAALAVTAA 497
+ +R+K ++++ + KR+ +K +AV+AA
Sbjct: 549 RCNRRLKSQILLKK------YLMKRRWKKNFIAVSAA 579
>Hs14758219 [T] KOG0694 Serine/threonine protein kinase
Length = 942
Score = 88.2 bits (217), Expect = 3e-17
Identities = 77/292 (26%), Positives = 132/292 (44%), Gaps = 38/292 (13%)
Query: 120 TTRDAPMSLTPTGVSMMQQETDETATLTTQI---ARLSLTPENGIQLENLVRLSKIGAGN 176
++RD P S + + + E + T + A S ++ + LE+ L+ +G G+
Sbjct: 566 SSRDPPSSPSSLSSPIQESTAPELPSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGH 625
Query: 177 SGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSA------HDNIVGFYG 230
G V+ + P + A K + + +++ V L K + A H +V +G
Sbjct: 626 FGKVLLSEFRPSGELFAIKAL--KKGDIVARDEVESLMCEKRILAAVTSAGHPFLVNLFG 683
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
F P + +MEY G L + + F+E S CV
Sbjct: 684 CFQTPE---HVCFVMEYSAGGDL----------------MLHIHSDVFSEPRAIFYSACV 724
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN--SLADTFVGTSTYMS 348
+ GL +L++ +KI++RD+K N+L++++G VKI DFG+ + TF GT +++
Sbjct: 725 VLGLQFLHE-HKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLA 783
Query: 349 PERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
PE + YT D W LG+++ E+ GE P G D E + D IVN+
Sbjct: 784 PEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPG--DDEEEVFD---SIVND 830
>At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 599
Score = 88.2 bits (217), Expect = 3e-17
Identities = 82/270 (30%), Positives = 125/270 (45%), Gaps = 41/270 (15%)
Query: 192 IAKKTIPVEN--KEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMD 249
+A K IP + + RE+ I++ +S H N+V FY AF + + + I+ME
Sbjct: 173 VAVKVIPKSKMTSAISIEDVRREVKILRALSGHQNLVQFYDAFEDNAN---VYIVMELCG 229
Query: 250 CGSL-DKILS---VYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIH 305
G L D+IL+ Y D K V I L+ ++FC L G ++H
Sbjct: 230 GGELLDRILARGGKYSED-DAKAVLIQI---------LNVVAFCHLQG---------VVH 270
Query: 306 RDIKPSNILINSKGD---VKICDFGVSTTLI-NSLADTFVGTSTYMSPERIQGGRYTTKG 361
RD+KP N L SK + +K+ DFG+S + + + VG++ Y++PE + YTT+
Sbjct: 271 RDLKPENFLYTSKEENSMLKVIDFGLSDFVRPDERLNDIVGSAYYVAPEVLHRS-YTTEA 329
Query: 362 DVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN--EHYSIEMTDFV 419
DVWS+G++ L G P T GI R V + P + S E DFV
Sbjct: 330 DVWSIGVIAYILLCGSRPFWAR--TESGIF----RAVLKADPSFDEPPWPSLSFEAKDFV 383
Query: 420 NRCCIKEERGRSSLKELICHDFICKYNNRD 449
R K+ R R + + + H +I Y D
Sbjct: 384 KRLLYKDPRKRMTASQALMHPWIAGYKKID 413
>YLR362w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 717
Score = 87.8 bits (216), Expect = 3e-17
Identities = 61/176 (34%), Positives = 94/176 (52%), Gaps = 25/176 (14%)
Query: 209 LVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKN 268
L E+ ++K + H+NIV +YGA N I +EY+ GS+ +L+ Y
Sbjct: 501 LQHEMNLLKELH-HENIVTYYGASQEGGNLN---IFLEYVPGGSVSSMLNNYGP------ 550
Query: 269 VSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGV 328
F E ++ + +L G+ YL+ IIHRDIK +NILI+ KG VKI DFG+
Sbjct: 551 ---------FEESLITNFTRQILIGVAYLHK-KNIIHRDIKGANILIDIKGCVKITDFGI 600
Query: 329 STTL--INSLAD---TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFP 379
S L +N + + G+ +MSPE ++ T K D+WS G ++IE+ +G+ P
Sbjct: 601 SKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHP 656
>YBL016w [T] KOG0660 Mitogen-activated protein kinase
Length = 353
Score = 87.8 bits (216), Expect = 3e-17
Identities = 65/219 (29%), Positives = 102/219 (45%), Gaps = 34/219 (15%)
Query: 170 SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFY 229
S +G G G V H P I+A K I +K + + +RE+ I+K+ H+NI+ +
Sbjct: 17 SLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFK-HENIITIF 75
Query: 230 GAFYNPS--TTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
S NE+ I+ E M ++D HR T ++ +
Sbjct: 76 NIQRPDSFENFNEVYIIQELM------------QTDLHRV-----ISTQMLSDDHIQYFI 118
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADT-------- 339
+ L + L+ +IHRD+KPSN+LINS D+K+CDFG++ + S AD
Sbjct: 119 YQTLRAVKVLHGS-NVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQS 177
Query: 340 ----FVGTSTYMSPE-RIQGGRYTTKGDVWSLGLMIIEL 373
+V T Y +PE + +Y+ DVWS G ++ EL
Sbjct: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAEL 216
>CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 357
Score = 87.8 bits (216), Expect = 3e-17
Identities = 93/322 (28%), Positives = 149/322 (45%), Gaps = 65/322 (20%)
Query: 158 ENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTI----------------PVEN 201
E+ IQL + +IG G+ G V + D + A K + P N
Sbjct: 13 ESYIQLNQYRLMEEIGQGSYGIVKLAYNEEDKNLYALKVLDKMKLLKNFACFRQPPPRRN 72
Query: 202 KE-----VLKN--QLV-RELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSL 253
KE VL+N QLV +E+ I+K +S H N+V +P+ N + ++ E+++ GS+
Sbjct: 73 KENAAPSVLRNPLQLVQKEIAILKKLS-HPNVVKLVEVLDDPND-NYLYMVFEFVEKGSI 130
Query: 254 DKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNI 313
+I + K + S+F + L GL YL+ KI+HRDIKPSN+
Sbjct: 131 LEIPT-------DKPLDEDTAWSYFRD---------TLCGLEYLH-YQKIVHRDIKPSNL 173
Query: 314 LINSKGDVKICDFGVSTTL--INSLADTFVGTSTYMSPERI-QGGRYTTKG---DVWSLG 367
L++ G VKI DFGVS I++ GT +M+PE + +G + G D+WSLG
Sbjct: 174 LLSDIGQVKIADFGVSCEFEGIDAFLSGTAGTPAFMAPEALTEGANHFYSGRAQDIWSLG 233
Query: 368 LMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP-----APKLSKNEHYSIEMTDFVNRC 422
+ + G P ++ I+ L ++I N+P AP LS+ + D +
Sbjct: 234 ITLYAFVIGTVPFVDNY-----IIALHKKIKNDPIVFPEAPILSE------ALQDIILGM 282
Query: 423 CIKEERGRSSLKELICHDFICK 444
K+ R L E+ H ++ +
Sbjct: 283 LKKDPGHRLMLHEVKVHTWVTR 304
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 87.8 bits (216), Expect = 3e-17
Identities = 79/283 (27%), Positives = 136/283 (47%), Gaps = 40/283 (14%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVL----KNQLVRELTIMKNVSAHDNIV 226
+IG+G+ V H +A K I +K++L ++ L++E++I+ + H NI+
Sbjct: 15 RIGSGSFAVVWLAKHRSSGLEVAVKEI---DKKLLSPKVRDNLLKEISILSTID-HPNII 70
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
FY A T + I +++EY G L ++ V + + ++ L
Sbjct: 71 RFYEAI---ETGDRIFLVLEYCSGGDLAGYIN------RHGKVPEAVAKHFMRQLAL--- 118
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGD---VKICDFGVSTTLI-NSLADTFVG 342
GL L + + IHRD+KP N+L++SK +KI DFG + +L S+A+TF G
Sbjct: 119 ------GLQVLQEKH-FIHRDLKPQNLLLSSKEVTPLLKIGDFGFARSLTPESMAETFCG 171
Query: 343 TSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPA 402
+ YM+PE I+ +Y K D+WS G ++ +L +G+ P G++ + L IV +
Sbjct: 172 SPLYMAPEIIRNQKYDAKADLWSAGAILFQLVTGKPPFDGNNH-----IQLFHNIVRDTE 226
Query: 403 PKLSKNEHYSIEMTDFVNRCCIKEERG---RSSLKELICHDFI 442
K ++ I D V+ C R R + +E H F+
Sbjct: 227 LKFPEDTRNEIH-PDCVDLCRSLLRRNPIERLTFREFFNHMFL 268
>At1g78530 [T] KOG1187 Serine/threonine protein kinase
Length = 355
Score = 87.8 bits (216), Expect = 3e-17
Identities = 72/213 (33%), Positives = 109/213 (50%), Gaps = 26/213 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G+G GTV + L + DS A K + E + REL M ++ H NIV +G
Sbjct: 81 LGSGGFGTVYR-LVIDDSTTFAVKRLNRGTSERDRG-FHRELEAMADIK-HRNIVTLHGY 137
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVL 291
F +P +++ E M GSLD L ++ W + RI+
Sbjct: 138 FTSPHYN---LLIYELMPNGSLDSFLHGRKA------------LDWASRY---RIAVGAA 179
Query: 292 NGLIYLY-DCYK-IIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADTFV-GTSTY 346
G+ YL+ DC IIHRDIK SNIL++ + ++ DFG++T + + TFV GT Y
Sbjct: 180 RGISYLHHDCIPHIIHRDIKSSNILLDHNMEARVSDFGLATLMEPDKTHVSTFVAGTFGY 239
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFP 379
++PE G+ T KGDV+S G++++EL +G P
Sbjct: 240 LAPEYFDTGKATMKGDVYSFGVVLLELLTGRKP 272
>At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 594
Score = 87.8 bits (216), Expect = 3e-17
Identities = 85/331 (25%), Positives = 150/331 (44%), Gaps = 50/331 (15%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
++G G S TV + + + I+A K + +E + +E+ IM + H N++ +
Sbjct: 21 EVGEGVSATVYRARCIALNEIVAVKILDLEKCRNDLETIRKEVHIMSLID-HPNLLKAHC 79
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKIL-SVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
+F + S+ + I+M YM GS ++ SVY + ++ +
Sbjct: 80 SFIDSSS---LWIVMPYMSGGSCFHLMKSVYPEGLEQPIIATLLRE-------------- 122
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS-----LADTFVGTS 344
VL L+YL+ IHRD+K NILI+SKG VK+ DFGVS + +S +TFVGT
Sbjct: 123 VLKALVYLHR-QGHIHRDVKAGNILIHSKGVVKLGDFGVSACMFDSGERMQTRNTFVGTP 181
Query: 345 TYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTP----EGILDLLQRIVNE 400
+M+PE +Q +L +F H P + LL + N
Sbjct: 182 CWMAPEVMQ------------------QLDGYDFKYLAHGHAPFSKYPPMKVLLMTLQNA 223
Query: 401 PAPKL--SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHW 458
P P+L +++ +S + + C +K+ + R + +L+ H F + D ++++ H
Sbjct: 224 P-PRLDYDRDKKFSKSFRELIAACLVKDPKKRPTAAKLLKHPFFKHARSTDYLSRKILHG 282
Query: 459 CKKVKKRIKEDKMIRREETERSKIEKRQLEK 489
+ +R K+ K E + +K QL +
Sbjct: 283 LSPLGERFKKLKEAEAELFKGINGDKEQLSQ 313
>7299437 [R] KOG0586 Serine/threonine protein kinase
Length = 604
Score = 87.8 bits (216), Expect = 3e-17
Identities = 76/277 (27%), Positives = 124/277 (44%), Gaps = 31/277 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIP-VENKEVLKNQLVRELTIMKNVSAHDNIVG 227
+ +G GN V +H+P R +A K I + + +L RE+ IMK ++ H NIV
Sbjct: 66 IKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTIARQKLYREVNIMKKLN-HPNIVR 124
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+ T + ++MEY+ G L L K E +R+
Sbjct: 125 LLQVIESERT---LYLVMEYVSGGELFNYL---------------VKNGRMRERD-ARVL 165
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-INSLADTFVGTSTY 346
F L I I+HRD+K N+L++ + +KI DFG STT + +TF G+ Y
Sbjct: 166 FRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPY 225
Query: 347 MSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
+PE +G +Y+ + D WSLG+++ L SG P G + +L R++ K
Sbjct: 226 AAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDG-----TNLKELRDRVLR---GKY 277
Query: 406 SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
+ SIE + + + R+SL ++ +I
Sbjct: 278 RVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWI 314
>Hs18602554 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 227
Score = 87.4 bits (215), Expect = 4e-17
Identities = 68/221 (30%), Positives = 103/221 (45%), Gaps = 27/221 (12%)
Query: 224 NIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPL 283
NIV F ++ +E+ +++EY+ GSL +++ D ++ C+ S
Sbjct: 8 NIVNFLDSYL---VGDELFVVVEYLARGSLTDVVTETCMD--EAQIAAVCRES------- 55
Query: 284 SRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI--NSLADTFV 341
L L +L+ ++IHRDIK ++L+ +G VK+ DFG + S T V
Sbjct: 56 -------LQALEFLH-ANQVIHRDIKSDSVLLGMEGSVKLTDFGFCAQITPEQSKRSTVV 107
Query: 342 GTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
T +M+PE + Y K +VWSLG+M E+ GE P E L L I
Sbjct: 108 RTPYWMAPEVVTRKAYGPKVNVWSLGIMATEMVEGEPPY-----LNENPLRALCLIATNG 162
Query: 402 APKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
P+L E S DF+NRC + R S KEL+ H F+
Sbjct: 163 IPELQNPETLSPIFRDFLNRCLETDVEKRGSAKELLQHLFL 203
>CE21025 [D] KOG0580 Serine/threonine protein kinase
Length = 326
Score = 87.0 bits (214), Expect = 6e-17
Identities = 71/282 (25%), Positives = 128/282 (45%), Gaps = 28/282 (9%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVL--KNQLVRELTIMKNVSAHDNIVGFY 229
+G G G V + RIIA K + L +QL RE+ I ++ H NI+ Y
Sbjct: 50 LGKGKFGNVFISREKKTKRIIALKVLFKTQLLQLGVSHQLKREIEIQYHLR-HPNILTLY 108
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
G F++ + ++++Y G L +L H+ N I+ + F + + +C
Sbjct: 109 GYFHDDK---RVFVILDYASRGELFNVLQSQPG--HKVNEVIAGR---FVRQLANALHYC 160
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
G +IHRDIKP N+L++SK ++K+ DFG S +S T GT Y++P
Sbjct: 161 HSKG---------VIHRDIKPENLLLDSKLNLKLADFGWSVVADHSKRHTLCGTMDYLAP 211
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE 409
E + + D+W++G+++ E+ G P + T + ++ ++ K+
Sbjct: 212 EMVSNQPHDFNVDIWAIGILLFEMLVGYAPFA--NQTGDKLIARIKEC------KIYIPS 263
Query: 410 HYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTI 451
+ +N KE + R L +++ H +I + R+ I
Sbjct: 264 VVTDGAASLINAIIKKEPQERLPLVDIMAHPWIKEMKQREDI 305
>7299322 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 434
Score = 87.0 bits (214), Expect = 6e-17
Identities = 82/283 (28%), Positives = 132/283 (45%), Gaps = 33/283 (11%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKN--QLVRELTIMKNVSAHDNIV 226
+ K+G G G V ++ + +A KTI E + ++ RE+ IM +V H NI+
Sbjct: 85 IKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVH-HPNII 143
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
Y F N ++V++ME+ G L LS RK ++ E RI
Sbjct: 144 HIYEVFEN---REKMVLVMEFAAGGELYDYLS------ERKVLT---------EEEARRI 185
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS-LADTFVGTST 345
V + Y + +KI HRD+K NIL++ KG+ KI DFG+S + L TF G+
Sbjct: 186 FRQVATAVYYCHK-HKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPL 244
Query: 346 YMSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPK 404
Y SPE ++G Y + D WSLG+++ L G P G L+++I +
Sbjct: 245 YASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDG-----SNFKRLVKQISQGDYYE 299
Query: 405 LSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNN 447
K S + D + C R R+S++++ H ++ + +N
Sbjct: 300 PRKPSRASTLIRDMLTVC----PRKRASIEQICSHWWVNENDN 338
>YKL101w [D] KOG0588 Serine/threonine protein kinase
Length = 1518
Score = 86.7 bits (213), Expect = 8e-17
Identities = 72/266 (27%), Positives = 126/266 (47%), Gaps = 40/266 (15%)
Query: 211 RELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVS 270
RE+ IMK +S H N++ + + N S E+ +++EY+D G L L R+ +
Sbjct: 163 REIVIMKLIS-HTNVMALFEVWENKS---ELYLVLEYVDGGELFDYLVSKGKLPEREAIH 218
Query: 271 ISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKG-DVKICDFGVS 329
+F ++ + +S+C + I HRD+KP N+L++ K +KI DFG++
Sbjct: 219 ------YFKQI-VEGVSYC---------HSFNICHRDLKPENLLLDKKNRRIKIADFGMA 262
Query: 330 T-TLINSLADTFVGTSTYMSPERIQGGRY-TTKGDVWSLGLMIIELSSGEFPLGGHHDTP 387
L N L T G+ Y SPE + G Y DVWS G+++ L +G P
Sbjct: 263 ALELPNKLLKTSCGSPHYASPEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPF-----ND 317
Query: 388 EGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNN 447
+ I LL ++ + K + S E D +++ + + R + +E++ H I KY++
Sbjct: 318 DNIKKLLLKV---QSGKYQMPSNLSSEARDLISKILVIDPEKRITTQEILKHPLIKKYDD 374
Query: 448 RDTIAKEFRHWCKKVKKRIKEDKMIR 473
KV +++++D M R
Sbjct: 375 LPV---------NKVLRKMRKDNMAR 391
>Hs4758702 [T] KOG4279 Serine/threonine protein kinase
Length = 1011
Score = 86.7 bits (213), Expect = 8e-17
Identities = 89/276 (32%), Positives = 126/276 (45%), Gaps = 28/276 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
+G G G V IA K IP E L E+ + + + H NIV + G+
Sbjct: 377 LGKGTYGVVYAGRDRHTRVRIAIKEIP-ERDSRFSQPLHEEIALHRRLR-HKNIVRYLGS 434
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVL 291
S + I ME + GSL +L ++V K NE +S + +L
Sbjct: 435 ---ASQGGYLKIFMEEVPGGSLSSLL---------RSVWGPLKD---NESTISFYTRQIL 479
Query: 292 NGLIYLYDCYKIIHRDIKPSNILINS-KGDVKICDFGVSTTL--INSLADTFVGTSTYMS 348
GL YL+D + I+HRDIK N+LIN+ G +KI DFG S L I +TF GT YM+
Sbjct: 480 QGLGYLHDNH-IVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMA 538
Query: 349 PERI-QGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
PE I QG R Y D+WSLG +IE+++G P + + V+ P P
Sbjct: 539 PEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMP--- 595
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
S E F+ R + R R+S + L+ F+
Sbjct: 596 --SSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL 629
>Hs4507361 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 579
Score = 86.7 bits (213), Expect = 8e-17
Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 53/323 (16%)
Query: 126 MSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLH 185
MS S E +Q+ I++E +V G G G V K
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVV-----GRGAFGVVCKAKW 55
Query: 186 VPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILM 245
++ +A K I E++ + + EL + V+ H NIV YGA NP + ++M
Sbjct: 56 --RAKDVAIKQIESESE---RKAFIVELRQLSRVN-HPNIVKLYGACLNP-----VCLVM 104
Query: 246 EYMDCGSLDKILS-----VYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDC 300
EY + GSL +L Y + H + + C G+ YL+
Sbjct: 105 EYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS-----------------QGVAYLHSM 147
Query: 301 YK--IIHRDIKPSNILINSKGDV-KICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRY 357
+IHRD+KP N+L+ + G V KICDFG + + + + G++ +M+PE +G Y
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN-KGSAAWMAPEVFEGSNY 206
Query: 358 TTKGDVWSLGLMIIELSSGEFP---LGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIE 414
+ K DV+S G+++ E+ + P +GG ++ + N P L KN IE
Sbjct: 207 SEKCDVFSWGIILWEVITRRKPFDEIGG------PAFRIMWAVHNGTRPPLIKNLPKPIE 260
Query: 415 MTDFVNRCCIKEERGRSSLKELI 437
+ RC K+ R S++E++
Sbjct: 261 --SLMTRCWSKDPSQRPSMEEIV 281
>Hs21735566 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 491
Score = 86.7 bits (213), Expect = 8e-17
Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 53/323 (16%)
Query: 126 MSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLH 185
MS S E +Q+ I++E +V G G G V K
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVV-----GRGAFGVVCKAKW 55
Query: 186 VPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILM 245
++ +A K I E++ + + EL + V+ H NIV YGA NP + ++M
Sbjct: 56 --RAKDVAIKQIESESE---RKAFIVELRQLSRVN-HPNIVKLYGACLNP-----VCLVM 104
Query: 246 EYMDCGSLDKILS-----VYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDC 300
EY + GSL +L Y + H + + C G+ YL+
Sbjct: 105 EYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS-----------------QGVAYLHSM 147
Query: 301 YK--IIHRDIKPSNILINSKGDV-KICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRY 357
+IHRD+KP N+L+ + G V KICDFG + + + + G++ +M+PE +G Y
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN-KGSAAWMAPEVFEGSNY 206
Query: 358 TTKGDVWSLGLMIIELSSGEFP---LGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIE 414
+ K DV+S G+++ E+ + P +GG ++ + N P L KN IE
Sbjct: 207 SEKCDVFSWGIILWEVITRRKPFDEIGG------PAFRIMWAVHNGTRPPLIKNLPKPIE 260
Query: 415 MTDFVNRCCIKEERGRSSLKELI 437
+ RC K+ R S++E++
Sbjct: 261 --SLMTRCWSKDPSQRPSMEEIV 281
>Hs21735564 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 518
Score = 86.7 bits (213), Expect = 8e-17
Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 53/323 (16%)
Query: 126 MSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLH 185
MS S E +Q+ I++E +V G G G V K
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVV-----GRGAFGVVCKAKW 55
Query: 186 VPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILM 245
++ +A K I E++ + + EL + V+ H NIV YGA NP + ++M
Sbjct: 56 --RAKDVAIKQIESESE---RKAFIVELRQLSRVN-HPNIVKLYGACLNP-----VCLVM 104
Query: 246 EYMDCGSLDKILS-----VYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDC 300
EY + GSL +L Y + H + + C G+ YL+
Sbjct: 105 EYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS-----------------QGVAYLHSM 147
Query: 301 YK--IIHRDIKPSNILINSKGDV-KICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRY 357
+IHRD+KP N+L+ + G V KICDFG + + + + G++ +M+PE +G Y
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN-KGSAAWMAPEVFEGSNY 206
Query: 358 TTKGDVWSLGLMIIELSSGEFP---LGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIE 414
+ K DV+S G+++ E+ + P +GG ++ + N P L KN IE
Sbjct: 207 SEKCDVFSWGIILWEVITRRKPFDEIGG------PAFRIMWAVHNGTRPPLIKNLPKPIE 260
Query: 415 MTDFVNRCCIKEERGRSSLKELI 437
+ RC K+ R S++E++
Sbjct: 261 --SLMTRCWSKDPSQRPSMEEIV 281
>Hs21735562 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 606
Score = 86.7 bits (213), Expect = 8e-17
Identities = 86/323 (26%), Positives = 141/323 (43%), Gaps = 53/323 (16%)
Query: 126 MSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLH 185
MS S E +Q+ I++E +V G G G V K
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVV-----GRGAFGVVCKAKW 55
Query: 186 VPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILM 245
++ +A K I E++ + + EL + V+ H NIV YGA NP + ++M
Sbjct: 56 --RAKDVAIKQIESESE---RKAFIVELRQLSRVN-HPNIVKLYGACLNP-----VCLVM 104
Query: 246 EYMDCGSLDKILS-----VYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDC 300
EY + GSL +L Y + H + + C G+ YL+
Sbjct: 105 EYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCS-----------------QGVAYLHSM 147
Query: 301 YK--IIHRDIKPSNILINSKGDV-KICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRY 357
+IHRD+KP N+L+ + G V KICDFG + + + + G++ +M+PE +G Y
Sbjct: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNN-KGSAAWMAPEVFEGSNY 206
Query: 358 TTKGDVWSLGLMIIELSSGEFP---LGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIE 414
+ K DV+S G+++ E+ + P +GG ++ + N P L KN IE
Sbjct: 207 SEKCDVFSWGIILWEVITRRKPFDEIGG------PAFRIMWAVHNGTRPPLIKNLPKPIE 260
Query: 415 MTDFVNRCCIKEERGRSSLKELI 437
+ RC K+ R S++E++
Sbjct: 261 --SLMTRCWSKDPSQRPSMEEIV 281
>CE28479 [T] KOG0583 Serine/threonine protein kinase
Length = 822
Score = 86.7 bits (213), Expect = 8e-17
Identities = 79/287 (27%), Positives = 133/287 (45%), Gaps = 38/287 (13%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPV---ENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
IG GN TV H +A K+I V + + ++K L RE+ I+K + H +IV
Sbjct: 22 IGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIK--LEREVKIVKVID-HPHIVKS 78
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
Y N + I+ EY G L Y + + V+ + WF+E
Sbjct: 79 YEIM---RVDNMLYIVSEYCSSGEL------YETLIEKGRVAENVARKWFSE-------- 121
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI-NSLADTFVGTSTYM 347
+ + YL+ I+HRD+K NIL+ ++KI DFG S + L +T+ G+ Y
Sbjct: 122 -TASAVAYLHS-QGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYA 179
Query: 348 SPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
+PE + G Y K D+WS+G+++ L +G FP P ++ L+R V K+
Sbjct: 180 APELLLGNSYDGMKADIWSMGVLLYILVAGGFPF------PSDSVNKLKRSVLSGLVKIP 233
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAK 453
S+E DF+ + + R +++ ++ H ++ + RD + K
Sbjct: 234 --YWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWM---HIRDDVQK 275
>CE18699 [T] KOG0694 Serine/threonine protein kinase
Length = 1018
Score = 86.7 bits (213), Expect = 8e-17
Identities = 95/359 (26%), Positives = 150/359 (41%), Gaps = 60/359 (16%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNV- 219
+ +E +S +G G+ G V+ + H P S A K + + ++L V L + K +
Sbjct: 685 LTVEQFRLISVLGRGHFGKVILSQHNPTSNYYALKVL--KKGDILGRDEVESLMVEKRIF 742
Query: 220 -----SAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCK 274
+ H +V G F T + MEY G L + +
Sbjct: 743 EVSSRARHPFLVNLNGCF---QTNEHVFFCMEYSMGGDLMRHIH---------------- 783
Query: 275 TSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN 334
F+E+ + CV+ GL +L+ + II+RDIK N+L++ +G VKI DFG+ +
Sbjct: 784 DDVFDEVRGCFYAACVVLGLDFLHK-HNIIYRDIKLDNLLLDREGYVKIADFGLCKENMG 842
Query: 335 SL--ADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILD 392
TF GT +++PE + YT D W LG++I E+ GE P G D E I D
Sbjct: 843 PFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSG--DDEEEIFD 900
Query: 393 -LLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTI 451
++ V P + S+E + R K R E D I
Sbjct: 901 SIISEDVRYP-------RYLSVESIAIMRRLLRKVPEKRLGYGERDAEDI--------KI 945
Query: 452 AKEFRH----WCKKVKKRIK---EDKMIRREETERSKIEKRQLEKAALAVTAARSSSTR 503
+ FRH W K + + I+ + ++ E+ +E Q EKA + +SSTR
Sbjct: 946 QRFFRHISWEWDKLLNREIRPPFQPQIRNPEDVSNFDLEFTQ-EKARFSA----ASSTR 999
>At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 257
Score = 86.7 bits (213), Expect = 8e-17
Identities = 69/233 (29%), Positives = 116/233 (49%), Gaps = 30/233 (12%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVEN-KEVLKNQLVRELTIMKNVSAHDNIVGFY 229
+IG+G+ V + H D +A K I ++ + L+ L+ E+ I++ ++ H NI+
Sbjct: 17 QIGSGSFSVVWEARHRVDGTEVAIKEIAMDRLNKKLQESLMSEIFILRRIN-HPNIIRLI 75
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
+P ++ +++EY G L SVY R + F +
Sbjct: 76 DMIKSPG---KVHLVLEYCKGGDL----SVY---VQRHGIVPEATAKHFMQQ-------- 117
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSK---GDVKICDFGVSTTLI-NSLADTFVGTST 345
+ GL L D IIHRD+KP N+L+++ D+KI DFG + +L LA+T G+
Sbjct: 118 LAAGLQVLRD-NNIIHRDLKPQNLLLSTNENDADLKIADFGFARSLQPRGLAETLCGSPL 176
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
YM+PE +Q +Y K D+WS+G ++ +L +G P G+ + LLQ I+
Sbjct: 177 YMAPEIMQLQKYDAKADLWSVGAILFQLVTGRTPFTGNSQ-----IQLLQNII 224
>At1g70740 [T] KOG1187 Serine/threonine protein kinase
Length = 381
Score = 86.7 bits (213), Expect = 8e-17
Identities = 69/212 (32%), Positives = 113/212 (52%), Gaps = 23/212 (10%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
K+G G G V K +PD R IA K + +++ KN+ V E ++ V H N+V +G
Sbjct: 23 KLGEGGFGPVFKG-RLPDGRDIAVKKLSQVSRQG-KNEFVNEAKLLAKVQ-HRNVVNLWG 79
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
+ ++ +++ EY+ SLDK+L ++S+ RK+ + W I +
Sbjct: 80 YCTHG---DDKLLVYEYVVNESLDKVL--FKSN--RKS-----EIDWKQRF---EIITGI 124
Query: 291 LNGLIYLYDCYK--IIHRDIKPSNILINSKGDVKICDFGVSTTL---INSLADTFVGTST 345
GL+YL++ IIHRDIK NIL++ K KI DFG++ + + GT+
Sbjct: 125 ARGLLYLHEDAPNCIIHRDIKAGNILLDEKWVPKIADFGMARLYQEDVTHVNTRVAGTNG 184
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGE 377
YM+PE + G + K DV+S G++++EL SG+
Sbjct: 185 YMAPEYVMHGVLSVKADVFSFGVLVLELVSGQ 216
>7293496 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 805
Score = 86.7 bits (213), Expect = 8e-17
Identities = 75/277 (27%), Positives = 124/277 (44%), Gaps = 34/277 (12%)
Query: 170 SKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEV--LKNQLVRELTIMKNVSAHDNIVG 227
S +G G+ G V K DS+++A K I + LKN L RE I + H +++
Sbjct: 8 SMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKN-LRRECDIQARLK-HPHVIE 65
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+F + ++ ++ E+ D HR E P R++
Sbjct: 66 MIESF---ESKTDLFVVTEFA------------LMDLHR----YLSYNGAMGEEPARRVT 106
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGV--STTLINSLADTFVGTST 345
+++ L YL+ +I+HRD+KP N+L++ K+CDFG+ + TL + + GT
Sbjct: 107 GHLVSALYYLHS-NRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPL 165
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKL 405
YM+PE + Y D+WSLG + E +G+ P IL L++ I +E
Sbjct: 166 YMAPELLAEQPYDHHADMWSLGCIAYESMAGQPPF-----CASSILHLVKMIKHEDVKWP 220
Query: 406 SKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
S + E F+ K+ R S +L+CH F+
Sbjct: 221 ST---LTSECRSFLQGLLEKDPGLRISWTQLLCHPFV 254
>HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 86.3 bits (212), Expect = 1e-16
Identities = 95/354 (26%), Positives = 157/354 (43%), Gaps = 61/354 (17%)
Query: 161 IQLENLVRLSKIGAGNSGTV-VKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNV 219
+ E ++ L +G+G G V + H + + V+ LK ++ L +K
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFHGEE--------VAVKKVRDLKETDIKHLRKLK-- 169
Query: 220 SAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFN 279
H NI+ F G ILME+ G L ++L R V+ S W
Sbjct: 170 --HPNIITFKGVCTQAPC---YCILMEFCAQGQLYEVLRAGRP------VTPSLLVDW-- 216
Query: 280 EMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN-SLAD 338
S + G+ YL+ +KIIHRD+K N+LI VKI DFG S L + S
Sbjct: 217 -------SMGIAGGMNYLH-LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKM 268
Query: 339 TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
+F GT +M+PE I+ + K D+WS G+++ EL +GE P D+ I + +
Sbjct: 269 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY-KDVDSSAIIWGVGSNSL 327
Query: 399 NEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYN----NRDTIAKE 454
+ P P S + + I + +C + R R S ++++ H I + ++T K
Sbjct: 328 HLPVPS-SCPDGFKI----LLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKS 382
Query: 455 FRHWCKKVK-------------KRIKEDKMIRREETERSKIE-----KRQLEKA 490
W ++VK R++E+ ++RR E R ++ +R+LE+A
Sbjct: 383 QAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERA 436
>Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 661
Score = 86.3 bits (212), Expect = 1e-16
Identities = 66/218 (30%), Positives = 106/218 (48%), Gaps = 30/218 (13%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQ-----LVRELTIMKNVSAHDNIV 226
+G G G V + R++A K+I K+ +K++ + RE+ IM +++ H +I+
Sbjct: 61 LGKGTYGKVKRATERFSGRVVAIKSI---RKDKIKDEQDMVHIRREIEIMSSLN-HPHII 116
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
Y F N ++IVI+MEY G L +S R R+ T F +S +
Sbjct: 117 SIYEVFENK---DKIVIIMEYASKGELYDYISERRRLSERE-------TRHFFRQIVSAV 166
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-INSLADTFVGTST 345
+C NG ++HRD+K NIL++ ++KI DFG+S + TF G+
Sbjct: 167 HYCHKNG---------VVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPL 217
Query: 346 YMSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGG 382
Y SPE + G Y + D W+LG+++ L G P G
Sbjct: 218 YASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDG 255
>Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 86.3 bits (212), Expect = 1e-16
Identities = 95/354 (26%), Positives = 157/354 (43%), Gaps = 61/354 (17%)
Query: 161 IQLENLVRLSKIGAGNSGTV-VKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNV 219
+ E ++ L +G+G G V + H + + V+ LK ++ L +K
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFHGEE--------VAVKKVRDLKETDIKHLRKLK-- 169
Query: 220 SAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFN 279
H NI+ F G ILME+ G L ++L R V+ S W
Sbjct: 170 --HPNIITFKGVCTQAPC---YCILMEFCAQGQLYEVLRAGRP------VTPSLLVDW-- 216
Query: 280 EMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN-SLAD 338
S + G+ YL+ +KIIHRD+K N+LI VKI DFG S L + S
Sbjct: 217 -------SMGIAGGMNYLH-LHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKM 268
Query: 339 TFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
+F GT +M+PE I+ + K D+WS G+++ EL +GE P D+ I + +
Sbjct: 269 SFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPY-KDVDSSAIIWGVGSNSL 327
Query: 399 NEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYN----NRDTIAKE 454
+ P P S + + I + +C + R R S ++++ H I + ++T K
Sbjct: 328 HLPVPS-SCPDGFKI----LLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKS 382
Query: 455 FRHWCKKVK-------------KRIKEDKMIRREETERSKIE-----KRQLEKA 490
W ++VK R++E+ ++RR E R ++ +R+LE+A
Sbjct: 383 QAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERA 436
>CE27574 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 463
Score = 86.3 bits (212), Expect = 1e-16
Identities = 77/242 (31%), Positives = 113/242 (45%), Gaps = 29/242 (11%)
Query: 161 IQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTI--PVENKEVLKNQLVRELTIMKN 218
+ L+ L IG+G G V + +A K + P +N K + REL +M
Sbjct: 114 VVLKRYQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAK-RAYRELKLMSL 172
Query: 219 VSAHDNIVGFYGAFYNPSTT---NEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKT 275
V+ H NI+G F N++ I+ME MD + V + D +
Sbjct: 173 VN-HKNIIGILNCFTPQKKLDEFNDLYIVMELMDAN----LCQVIQMDLDHER------- 220
Query: 276 SWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS 335
LS + + +L G+ +L+ IIHRD+KPSNI++ S +KI DFG++ T I +
Sbjct: 221 -------LSYLLYQMLCGIRHLHSA-GIIHRDLKPSNIVVRSDCTLKILDFGLARTAIEA 272
Query: 336 LADT-FVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGE--FPLGGHHDTPEGILD 392
T +V T Y +PE I G Y DVWS+G + EL G FP G H D I++
Sbjct: 273 FMMTPYVVTRYYRAPEVILGMGYKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIE 332
Query: 393 LL 394
L
Sbjct: 333 QL 334
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 86.3 bits (212), Expect = 1e-16
Identities = 62/240 (25%), Positives = 118/240 (48%), Gaps = 32/240 (13%)
Query: 205 LKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDC 264
+++QL RE+ I +++ H NI+ Y F++ +I +++EY G + K L+V +
Sbjct: 71 VEHQLEREIEIQSHLN-HPNIIKLYTYFWD---AKKIYLVLEYAPGGEMYKQLTVSKR-- 124
Query: 265 HRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYK--IIHRDIKPSNILINSKGDVK 322
F+E ++ + + + L Y C++ +IHRDIKP N+LI S+G++K
Sbjct: 125 -------------FSEPTAAKYMYEIADALSY---CHRKNVIHRDIKPENLLIGSQGELK 168
Query: 323 ICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGG 382
I DFG S ++ T GT Y+ PE + G ++ D+W++G++ E G+ P
Sbjct: 169 IGDFGWSVHAPSNKRQTMCGTMDYLPPEMVNGADHSDAVDLWAIGVLCYEFLVGKPPF-E 227
Query: 383 HHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
H D + + A + + + D + R + + + R +L+++ H +I
Sbjct: 228 HEDQSKTYAAI-------KAARFTYPDSVKKGARDLIGRLLVVDPKARCTLEQVKEHYWI 280
>CE15235 [R] KOG0589 Serine/threonine protein kinase
Length = 357
Score = 86.3 bits (212), Expect = 1e-16
Identities = 57/181 (31%), Positives = 97/181 (53%), Gaps = 13/181 (7%)
Query: 206 KNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCH 265
+N + E+ ++K V H I+G+ +F N++ I+M+Y + G+L+++++ R+
Sbjct: 47 ENSIQSEVNLLKKVQ-HPLIIGYIDSFI---MDNQLGIVMQYAEGGTLERLINDQRA--- 99
Query: 266 RKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDV-KIC 324
+ S +F E + +L L +++ I+HRD+KP NIL+N + V K+
Sbjct: 100 ---IKDSNMREYFPEKTVLDYFTQILIALNHMHQ-KNIVHRDLKPQNILMNRRKTVLKLS 155
Query: 325 DFGVSTTL-INSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGH 383
DFG+S L S A T +GT Y+SPE + Y K D+WSLG ++ EL E G
Sbjct: 156 DFGISKELGTKSAASTVIGTPNYLSPEICESRPYNQKSDMWSLGCVLYELLQLERAFDGE 215
Query: 384 H 384
+
Sbjct: 216 N 216
>At1g67580 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 752
Score = 86.3 bits (212), Expect = 1e-16
Identities = 77/280 (27%), Positives = 135/280 (47%), Gaps = 27/280 (9%)
Query: 126 MSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLH 185
+S T + ++ ET E A+ T + +++ + ++ RL+KI G G V +
Sbjct: 369 LSETDSDDEYVRHETPEPAS--TPLRSINML-QGCRSVDEFERLNKIDEGTYGVVYRAKD 425
Query: 186 VPDSRIIAKKTIPVEN-KEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVIL 244
I+A K + +E +E +RE+ I+ + F++PS IV +
Sbjct: 426 KKTGEIVALKKVKMEKEREGFPLTSLREINILLS-------------FHHPS----IVDV 468
Query: 245 MEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKII 304
E + SLD I V H + F++ + + +L G+ YL+D + ++
Sbjct: 469 KEVVVGSSLDSIFMVMEYMEHDLKALMETMKQRFSQSEVKCLMLQLLEGVKYLHDNW-VL 527
Query: 305 HRDIKPSNILINSKGDVKICDFGVSTTLINSLA--DTFVGTSTYMSPERIQGGR-YTTKG 361
HRD+K SN+L+N++G++KICDFG++ + L V T Y +PE + G + Y+T
Sbjct: 528 HRDLKTSNLLLNNRGELKICDFGLARQYGSPLKPYTHLVVTLWYRAPELLLGAKQYSTAI 587
Query: 362 DVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEP 401
D+WSLG ++ EL G + + LD + RI+ P
Sbjct: 588 DMWSLGCIMAELLMKAPLFNGKTEFDQ--LDKIFRILGTP 625
>7299438 [R] KOG0586 Serine/threonine protein kinase
Length = 705
Score = 86.3 bits (212), Expect = 1e-16
Identities = 88/370 (23%), Positives = 162/370 (43%), Gaps = 38/370 (10%)
Query: 119 PTTRDAP-MSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNS 177
PTT +A + TPT + ++ T S NG + +++ +G GN
Sbjct: 52 PTTSNATALPATPTVAAGQDLGDGACSSKNTDSKFQSYVNGNGNGVYKIIKT--LGKGNF 109
Query: 178 GTVVKTLHVPDSRIIAKKTIP-VENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPS 236
V +HVP R +A K I + + +L RE+ IMK ++ H NIV + +
Sbjct: 110 AKVKLAIHVPTGREVAIKVIDKTQLNTSARQKLYREVKIMKLLN-HPNIVRLFQVIESER 168
Query: 237 TTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIY 296
T + ++MEY G L L K E I +++ + Y
Sbjct: 169 T---LYLVMEYASRGELFDHL---------------VKNGRMRERDARVIFRQLVSAIQY 210
Query: 297 LYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-INSLADTFVGTSTYMSPERIQGG 355
+ + ++HRD+K N+L++ ++KI DFG T N+ +TF G+ Y +PE G
Sbjct: 211 CHSKF-VVHRDLKAENLLLDQHMNIKIADFGFGNTFDPNAQLETFCGSPPYAAPELFMGR 269
Query: 356 RYT-TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIE 414
+Y + D WSLG+++ L SG P G + +L +R++ K + S++
Sbjct: 270 KYAGPEVDAWSLGVVLYTLVSGSLPFDG-----GTLKELRERVLR---GKYRVPYYISMD 321
Query: 415 MTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMI-- 472
+ + + + R+SL ++ +I ++ + FR +++ + D ++
Sbjct: 322 CENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDESDRLRPFREKPMELQDAARFDLLMSM 381
Query: 473 --RREETERS 480
+R + E+S
Sbjct: 382 GHKRRDVEQS 391
>SPBC11B10.09 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 297
Score = 85.9 bits (211), Expect = 1e-16
Identities = 60/215 (27%), Positives = 116/215 (53%), Gaps = 16/215 (7%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENK-EVLKNQLVRELTIMKNVSA 221
+EN ++ KIG G G V K H RI+A K I +E++ E + + +RE++++K V+
Sbjct: 1 MENYQKVEKIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEVND 60
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
+N +++ ++ E++D L K + +S + TS +
Sbjct: 61 ENNRSNCVRLLDILHAESKLYLVFEFLDM-DLKKYMD---------RISETGATS-LDPR 109
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTF- 340
+ + ++ ++NG+ + + +IIHRD+KP N+LI+ +G++K+ DFG++ + L +
Sbjct: 110 LVQKFTYQLVNGVNFCHS-RRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTH 168
Query: 341 -VGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIEL 373
+ T Y +PE + G R Y+T D+WS+G + E+
Sbjct: 169 EIVTLWYRAPEVLLGSRHYSTGVDIWSVGCIFAEM 203
>At3g45240 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 382
Score = 85.9 bits (211), Expect = 1e-16
Identities = 85/317 (26%), Positives = 139/317 (43%), Gaps = 40/317 (12%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKT--------IPVENKEVLKNQLVRELT 214
+ VR KIG+G+ G VV D + A K + V E ++RE+
Sbjct: 94 INEFVRERKIGSGSYGKVVLYRSTVDDKHYAIKAFHKSHLSRLRVAPSETAMGDVLREVM 153
Query: 215 IMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCK 274
IMK + H NIV +P ++ +++EY+D + S
Sbjct: 154 IMKTLE-HPNIVNLIEVIDDPEF-DDFYMVLEYVD---------------GKWAYDDSGP 196
Query: 275 TSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN 334
E+ + V+ GL+YL+ + +IH DIKP N+L+ S G VKI DF VS +
Sbjct: 197 PGALGEITARKYLRDVVAGLMYLH-AHNVIHGDIKPDNLLVTSTGRVKIGDFSVSQDDDD 255
Query: 335 SLADTFVGTSTYMSPERIQGGRYTTK-GDVWSLGLMIIELSSGEFPLGGHHDTPEGILDL 393
L + GT + +PE G Y+ + D W++G+ + + G++P G + + D
Sbjct: 256 QLRRS-PGTPVFTAPECCLGITYSGRSADTWAVGVTLYCMILGQYPFLG-----DTLQDT 309
Query: 394 LQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAK 453
+IV+ P L E + + D + K+ R +LK + H +I D
Sbjct: 310 YDKIVHNP---LIIPEGLNPRLRDLIEGLLCKDPNQRMTLKAVAEHPWI---TGEDGAIS 363
Query: 454 EFRHWCKKVKKRIKEDK 470
E+ WCK+ K +ED+
Sbjct: 364 EYCCWCKR-KAEEEEDQ 379
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 85.9 bits (211), Expect = 1e-16
Identities = 65/217 (29%), Positives = 101/217 (45%), Gaps = 23/217 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIP-VENKEVLKNQLVRELTIMKNVSAHDNIVG 227
+ IG GN V H+P + +A K I + +L RE+ IMK + H NIV
Sbjct: 154 IKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLD-HPNIVK 212
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+ T + ++MEY G + L ++ ++ +R+
Sbjct: 213 LFQVI---ETEKTLYLIMEYASGGEVFDYLVLHGRMKEKE----------------ARVK 253
Query: 288 FCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI-NSLADTFVGTSTY 346
F + + +IIHRD+K N+L++S+ ++KI DFG S S DTF G+ Y
Sbjct: 254 FRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPY 313
Query: 347 MSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGG 382
+PE QG +Y + DVWSLG+++ L SG P G
Sbjct: 314 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 350
>Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 1030
Score = 85.5 bits (210), Expect = 2e-16
Identities = 71/262 (27%), Positives = 119/262 (45%), Gaps = 31/262 (11%)
Query: 157 PENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIA-KKTIPVENKEVLKNQLVRELTI 215
P G + L +G G G V+K H I+A KK E E +K +REL +
Sbjct: 4 PNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKM 63
Query: 216 MKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKT 275
++ + +NIV AF ++ ++ EY++ L+ + +
Sbjct: 64 LRTLK-QENIVELKEAFRR---RGKLYLVFEYVEKNMLELLEEMP--------------- 104
Query: 276 SWFNEMPLSRISFCVLNGLIYLYDCYK--IIHRDIKPSNILINSKGDVKICDFGVSTTLI 333
N +P ++ + + ++ C+K I+HRDIKP N+LI+ +K+CDFG + L
Sbjct: 105 ---NGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLS 161
Query: 334 ---NSLADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGI 390
N+ +V T Y SPE + G Y D+WS+G ++ ELS G+ G + +
Sbjct: 162 EGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQ-- 219
Query: 391 LDLLQRIVNEPAPKLSKNEHYS 412
L +Q+++ P P YS
Sbjct: 220 LFTIQKVLG-PLPSEQMKLFYS 240
>Hs21361133 [R] KOG0586 Serine/threonine protein kinase
Length = 752
Score = 85.5 bits (210), Expect = 2e-16
Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 24/231 (10%)
Query: 169 LSKIGAGNSGTVVKTLHVPDSRIIAKKTIP-VENKEVLKNQLVRELTIMKNVSAHDNIVG 227
L IG GN V H+ R +A K I + +L RE+ IMK ++ H NIV
Sbjct: 59 LKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN-HPNIVK 117
Query: 228 FYGAFYNPSTTNEIVILMEYMDCGSLDKIL------------SVYRSDCHRKNVSISCKT 275
+ T + ++MEY G + L S +R C + +I +
Sbjct: 118 LFEVI---ETEKTLYLIMEYASGGEVFDYLVAHGKMKEKEARSKFRQGC-QAGQTIKVQV 173
Query: 276 SWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL-IN 334
S+ L + F + + +I+HRD+K N+L+++ ++KI DFG S +
Sbjct: 174 SF----DLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVG 229
Query: 335 SLADTFVGTSTYMSPERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHH 384
DTF G+ Y +PE QG +Y + DVWSLG+++ L SG P G +
Sbjct: 230 GKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQN 280
>At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 821
Score = 85.5 bits (210), Expect = 2e-16
Identities = 66/214 (30%), Positives = 112/214 (51%), Gaps = 20/214 (9%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
KIGAG+ GTV + S + K + + N+ +RE+ IMK + H NIV F G
Sbjct: 556 KIGAGSFGTVHRA-EWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLR-HPNIVLFMG 613
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
A P + I+ EY+ GSL ++L ++S + +E +++ V
Sbjct: 614 AVTQPPNLS---IVTEYLSRGSLYRLL--HKSGAREQ----------LDERRRLSMAYDV 658
Query: 291 LNGLIYLYDCYK-IIHRDIKPSNILINSKGDVKICDFGVSTTLINSL--ADTFVGTSTYM 347
G+ YL++ I+HRD+K N+L++ K VK+CDFG+S ++ + + GT +M
Sbjct: 659 AKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWM 718
Query: 348 SPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLG 381
+PE ++ K DV+S G+++ EL++ + P G
Sbjct: 719 APEVLRDEPSNEKSDVYSFGVILWELATLQQPWG 752
>At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 546
Score = 85.5 bits (210), Expect = 2e-16
Identities = 81/286 (28%), Positives = 143/286 (49%), Gaps = 33/286 (11%)
Query: 156 TPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVE--NKEVLKNQLVREL 213
T E I + L K+ +G+ G + + + S+ +A K + + N E+L+ + +E+
Sbjct: 276 TDEWEIDVTQLKIEKKVASGSYGDLHRGTYC--SQEVAIKFLKPDRVNNEMLR-EFSQEV 332
Query: 214 TIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISC 273
IM+ V H N+V F GA T + I+ E+M GS+ L H++ +
Sbjct: 333 FIMRKVR-HKNVVQFLGACTRSPT---LCIVTEFMARGSIYDFL-------HKQKCAFKL 381
Query: 274 KTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI 333
+T L +++ V G+ YL+ IIHRD+K +N+L++ G VK+ DFGV+ I
Sbjct: 382 QT-------LLKVALDVAKGMSYLHQ-NNIIHRDLKTANLLMDEHGLVKVADFGVARVQI 433
Query: 334 NS-LADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTP-EGIL 391
S + GT +M+PE I+ Y K DV+S +++ EL +G+ P TP + +
Sbjct: 434 ESGVMTAETGTYRWMAPEVIEHKPYNHKADVFSYAIVLWELLTGDIPYA--FLTPLQAAV 491
Query: 392 DLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELI 437
++Q+ + PK+ K H ++ + RC ++ R +E+I
Sbjct: 492 GVVQKGLR---PKIPKKTHPKVK--GLLERCWHQDPEQRPLFEEII 532
>At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 606
Score = 85.5 bits (210), Expect = 2e-16
Identities = 80/268 (29%), Positives = 125/268 (45%), Gaps = 39/268 (14%)
Query: 190 RIIAKKTIPVENKE--VLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEY 247
+++A K IP + + RE+ I++ +S H N+V FY AF + + + I ME
Sbjct: 177 QVVAVKIIPKSKMTTAIAIEDVRREVKILQALSGHKNLVQFYDAFEDNAN---VYIAMEL 233
Query: 248 MDCGSL-DKILSV--YRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKII 304
+ G L D+IL+ S+ K V I L+ ++FC G ++
Sbjct: 234 CEGGELLDRILARGGKYSENDAKPVIIQI---------LNVVAFCHFQG---------VV 275
Query: 305 HRDIKPSNILINSKGD---VKICDFGVSTTLI-NSLADTFVGTSTYMSPERIQGGRYTTK 360
HRD+KP N L SK + +K DFG+S + + + VG++ Y++PE + YTT+
Sbjct: 276 HRDLKPENFLYTSKEENSQLKAIDFGLSDFVRPDERLNDIVGSAYYVAPEVLHRS-YTTE 334
Query: 361 GDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKN--EHYSIEMTDF 418
DVWS+G++ L G P T GI R V + P + S + DF
Sbjct: 335 ADVWSIGVIAYILLCGSRPFWAR--TESGIF----RAVLKADPSFDEPPWPFLSSDAKDF 388
Query: 419 VNRCCIKEERGRSSLKELICHDFICKYN 446
V R K+ R R S + + H +I YN
Sbjct: 389 VKRLLFKDPRRRMSASQALMHPWIRAYN 416
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 85.1 bits (209), Expect = 2e-16
Identities = 80/283 (28%), Positives = 140/283 (49%), Gaps = 37/283 (13%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPV-----ENKEVLKN--QLVRELTIMKNVSAHDN 224
IG G+ G V L+V ++A K + V +N+ +L L E++ +K++ H N
Sbjct: 1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLD-HLN 1239
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
IV + G F N + N + +EY+ GS+ ++ +Y F+E +
Sbjct: 1240 IVQYLG-FENKN--NIYSLFLEYVAGGSVGSLIRMYGR---------------FDEPLIK 1281
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVS--TTLINSLAD-TFV 341
++ VL GL YL+ I+HRD+K N+L++ G KI DFG+S + I S +D T
Sbjct: 1282 HLTTQVLKGLAYLHS-KGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMR 1340
Query: 342 GTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNE 400
GT +M+PE + + Y+ K D+WSLG +++E+ +G+ P E + + + ++
Sbjct: 1341 GTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRP----WSNLEVVAAMFKIGKSK 1396
Query: 401 PAPKLSKNEHYSIEM--TDFVNRCCIKEERGRSSLKELICHDF 441
AP + ++ I +F++ C R + EL+ H F
Sbjct: 1397 SAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPF 1439
>Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 297
Score = 85.1 bits (209), Expect = 2e-16
Identities = 58/217 (26%), Positives = 112/217 (50%), Gaps = 22/217 (10%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEV-LKNQLVRELTIMKNVSA 221
+E+ ++ KIG G G V K H +++A K I +E++E + + +RE++++K +
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR- 59
Query: 222 HDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEM 281
H NIV S + ++ E++ S+D +K + + +
Sbjct: 60 HPNIVSLQDVLMQDS---RLYLIFEFL---SMDL----------KKYLDSIPPGQYMDSS 103
Query: 282 PLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTT--LINSLADT 339
+ + +L G+++ + +++HRD+KP N+LI+ KG +K+ DFG++ + +
Sbjct: 104 LVKSYLYQILQGIVFCHS-RRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTH 162
Query: 340 FVGTSTYMSPERIQG-GRYTTKGDVWSLGLMIIELSS 375
V T Y SPE + G RY+T D+WS+G + EL++
Sbjct: 163 EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT 199
>CE28218 [D] KOG0588 Serine/threonine protein kinase
Length = 914
Score = 85.1 bits (209), Expect = 2e-16
Identities = 63/228 (27%), Positives = 110/228 (47%), Gaps = 25/228 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVEN-KEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
+G G +G V H R +A K + E E + ++ RE+ IMK + H +++ Y
Sbjct: 53 LGKGQTGLVKTGTHCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIE-HPHVLHLYD 111
Query: 231 AFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCV 290
+ N + +L+E++ G L L RK +S + F +S + FC
Sbjct: 112 VYENKKY---LYLLLEHVSGGELFDYLV-------RKGRLMSKEARKFFRQIISALDFC- 160
Query: 291 LNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLI-NSLADTFVGTSTYMSP 349
+ I HRD+KP N+L++ + ++K+ DFG+++ + S+ +T G+ Y P
Sbjct: 161 --------HAHNICHRDLKPENLLLDERNNIKVADFGMASLQVEGSMLETSCGSPHYACP 212
Query: 350 ERIQGGRYT-TKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQR 396
E I+G +Y K DVWS G+++ L G P D +L+ ++R
Sbjct: 213 EVIRGEKYDGRKADVWSCGVILYALLVGALPF--DDDNLRNLLEKVKR 258
>CE24994 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 536
Score = 85.1 bits (209), Expect = 2e-16
Identities = 65/262 (24%), Positives = 122/262 (45%), Gaps = 23/262 (8%)
Query: 119 PTTRDAPMSLTPTGVSMMQQETDETATLTTQIARLSLTPENGIQLENLVRLSKIGAGNSG 178
P++ + S +P ++ Q+ T ++ +T PE Q + + +G G G
Sbjct: 9 PSSSSSSHSPSPAAITPTQRTTRDSGLCSTIDI-----PEIQAQCIDNLNSHYLGKGTYG 63
Query: 179 TVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTT 238
V KT + + + + ++ L+RE +M ++ H NI+ YG + +P
Sbjct: 64 LVEKTRYRKTRQDDFRPAAIKYSSQLHMATLIREAKVMWDLRNHPNIIKIYGLYKSPRNG 123
Query: 239 NEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLY 298
+V MEYMDCGS+ +L D N +I SW + L+ + +
Sbjct: 124 QGVV--MEYMDCGSMADLL----YDRTHINYTIDHVASWMFQ----------LSSAVDFF 167
Query: 299 DCYKIIHRDIKPSNILINSK-GDVKICDFGVSTTLINSLADTFVGTSTYMSPERIQGGRY 357
+HRD+K N+L++ + +K+CDFG T++ S+ GT M+PE + +Y
Sbjct: 168 HSNSQVHRDLKLQNMLLSDRYRTMKLCDFGTFTSMHQSMTSN-RGTPITMAPEVFRCEQY 226
Query: 358 TTKGDVWSLGLMIIELSSGEFP 379
K D++S+G+++ ++ + P
Sbjct: 227 NMKSDIYSIGIIMWQIIARNHP 248
>CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD and related
proteins
Length = 1101
Score = 85.1 bits (209), Expect = 2e-16
Identities = 73/252 (28%), Positives = 119/252 (46%), Gaps = 24/252 (9%)
Query: 162 QLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVR-ELTIMKNVS 220
QL + +G+G GTV +H + + +A K I K L+R E+ I++ V
Sbjct: 766 QLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQILEKVD 825
Query: 221 AHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNE 280
H +V F TT+ I ++ME + L+ ILS + +S +T+ F
Sbjct: 826 -HPGVVHFMQML---ETTDRIFVVMEKLKGDMLEMILSSEKG-------RLSERTTQF-- 872
Query: 281 MPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGD---VKICDFGVSTTL-INSL 336
+ +L L YL+ I+H D+KP NIL+NS D VK+CDFG + + S
Sbjct: 873 -----LVAQILEALRYLHHL-NIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGEKSF 926
Query: 337 ADTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQR 396
+ VGT Y++PE ++ + D+WS+G+++ SG FP D + I +
Sbjct: 927 RRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAEFM 986
Query: 397 IVNEPAPKLSKN 408
P ++S+N
Sbjct: 987 YPPTPWKEISEN 998
>CE03080 [R] KOG0584 Serine/threonine protein kinase
Length = 1851
Score = 85.1 bits (209), Expect = 2e-16
Identities = 73/277 (26%), Positives = 129/277 (46%), Gaps = 25/277 (9%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYG 230
++G G+ TV + L +A + + Q RE M H NIV FY
Sbjct: 349 ELGRGSFKTVFRGLDTETGVAVAWCELQESKLNKTERQRFREEAEMLKDLQHPNIVRFYD 408
Query: 231 AFYNPSTTNE---IVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRIS 287
+ + + IV++ E M G+L L ++ R N+ + K SW +
Sbjct: 409 YWESADLCGKRKYIVLVTELMTSGTLKMYLKRFK----RINIKVVLK-SWCRQ------- 456
Query: 288 FCVLNGLIYLYDCYK-IIHRDIKPSNILIN-SKGDVKICDFGVSTTLINSLADTFVGTST 345
+L GL +L+ +IHRD+K NI I + G VKI D G++T S A + +GT
Sbjct: 457 --ILKGLSFLHTRNPPVIHRDLKCDNIFITGTTGSVKIGDLGLATLKNKSFAKSVIGTPE 514
Query: 346 YMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPK- 404
+M+PE + Y DV++ G+ ++E+ +GE+P + + +++++ P+
Sbjct: 515 FMAPEMYE-EMYDESVDVYAFGMCLLEMVTGEYP----YSECMNPATIYRKVISGVKPEC 569
Query: 405 LSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDF 441
S+ E+ + ++RC RS++K+L+ DF
Sbjct: 570 FSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDF 606
>At2g34180 [T] KOG0583 Serine/threonine protein kinase
Length = 502
Score = 85.1 bits (209), Expect = 2e-16
Identities = 84/339 (24%), Positives = 146/339 (42%), Gaps = 49/339 (14%)
Query: 145 TLTTQIARLSLTPENGIQLENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--K 202
T T + R TP+ I ++ +G G+ V ++ +A K I E K
Sbjct: 36 TSTPESPRSPRTPQGSILMDKYEIGKLLGHGSFAKVYLARNIHSGEDVAIKVIDKEKIVK 95
Query: 203 EVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRS 262
L + RE++I++ V H IV +T +I I+MEY+ G L ++
Sbjct: 96 SGLAGHIKREISILRRVR-HPYIVHLLEVM---ATKTKIYIVMEYVRGGELYNTVA---- 147
Query: 263 DCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVK 322
R + +F ++ +S ++FC G + HRD+K N+L++ KG+VK
Sbjct: 148 ---RGRLREGTARRYFQQL-ISSVAFCHSRG---------VYHRDLKLENLLLDDKGNVK 194
Query: 323 ICDFGVSTT----LINSLADTFVGTSTYMSPERI-QGGRYTTKGDVWSLGLMIIELSSGE 377
+ DFG+S + TF GT Y++PE + + G K D+WS G+++ L +G
Sbjct: 195 VSDFGLSVVSEQLKQEGICQTFCGTPAYLAPEVLTRKGYEGAKADIWSCGVILFVLMAGY 254
Query: 378 FPLGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELI 437
P + IL + +I + + +S E+ V R R ++ E++
Sbjct: 255 LPF-----DDKNILVMYTKIYK---GQFKCPKWFSPELARLVTRMLDTNPDTRITIPEIM 306
Query: 438 CHDFICKYNNRDTIAKEFRHWCKKVKKRIKEDKMIRREE 476
H + F+ K VK I+ DK+ R ++
Sbjct: 307 KH-------------RWFKKGFKHVKFYIENDKLCREDD 332
>SPAC23H4.02 [T] KOG0583 Serine/threonine protein kinase
Length = 532
Score = 84.7 bits (208), Expect = 3e-16
Identities = 67/213 (31%), Positives = 101/213 (46%), Gaps = 27/213 (12%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTI---PVENKEVLKNQLVRELTIMKNVSAHDNIVGF 228
+G GN V H + +A K + +E+K+ K +L RE+TI++ + H NI+
Sbjct: 29 LGQGNLAKVKLGKHFQTNEKVALKMVYNDELEDKDTWK-RLQREVTILRQLH-HPNIITL 86
Query: 229 YGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISF 288
Y F P T V+ +EYMD ++ R D C T + I +
Sbjct: 87 YQVFRVPKYT---VLALEYMDTDLHSMVVKHNRLD--------ECTTRKIFRQIVHAIDY 135
Query: 289 CVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLIN-SLADTFVGTSTYM 347
C L +++ HRD+K NIL+N VK+ DFG+S +++ S T GT Y
Sbjct: 136 CHL---------HRVAHRDLKLENILLNKDLVVKLTDFGLSNFMLDGSFLSTSCGTPHYA 186
Query: 348 SPERIQGGRYT-TKGDVWSLGLMIIELSSGEFP 379
+PE IQG Y DVW G+++ + GEFP
Sbjct: 187 APEVIQGRYYDGCDVDVWGCGILLYLMLVGEFP 219
>CE24971 [T] KOG0660 Mitogen-activated protein kinase
Length = 444
Score = 84.7 bits (208), Expect = 3e-16
Identities = 69/244 (28%), Positives = 115/244 (46%), Gaps = 29/244 (11%)
Query: 167 VRLSKIGAGNSGTVVKTLH-VPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNI 225
V LS IG G G V L + R+ KK P E++ + L RE+ I+ N H+NI
Sbjct: 97 VNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTL-REIKIL-NRFKHENI 154
Query: 226 VGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRK-NVSISCKTSWFNEMPLS 284
+ + E + ++D + +Y C + ++ KT + +
Sbjct: 155 IN----------------IQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVC 198
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVS-----TTLINSLADT 339
+ +L GL Y++ ++HRD+KPSN+L+N+ D+KICDFG++ T
Sbjct: 199 YFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTE 257
Query: 340 FVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
+V T Y +PE + + YT DVWS+G ++ E+ S G H + L+L+ +V
Sbjct: 258 YVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQ--LNLILAVV 315
Query: 399 NEPA 402
P+
Sbjct: 316 GSPS 319
>CE01583 [T] KOG0660 Mitogen-activated protein kinase
Length = 376
Score = 84.7 bits (208), Expect = 3e-16
Identities = 69/244 (28%), Positives = 115/244 (46%), Gaps = 29/244 (11%)
Query: 167 VRLSKIGAGNSGTVVKTLH-VPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNI 225
V LS IG G G V L + R+ KK P E++ + L RE+ I+ N H+NI
Sbjct: 29 VNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTL-REIKIL-NRFKHENI 86
Query: 226 VGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRK-NVSISCKTSWFNEMPLS 284
+ + E + ++D + +Y C + ++ KT + +
Sbjct: 87 IN----------------IQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVC 130
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVS-----TTLINSLADT 339
+ +L GL Y++ ++HRD+KPSN+L+N+ D+KICDFG++ T
Sbjct: 131 YFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLARVTDPQTDHTGFLTE 189
Query: 340 FVGTSTYMSPERIQGGR-YTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIV 398
+V T Y +PE + + YT DVWS+G ++ E+ S G H + L+L+ +V
Sbjct: 190 YVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQ--LNLILAVV 247
Query: 399 NEPA 402
P+
Sbjct: 248 GSPS 251
>At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 84.7 bits (208), Expect = 3e-16
Identities = 81/304 (26%), Positives = 125/304 (40%), Gaps = 63/304 (20%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIVGFYGA 231
IG G S V + L +P ++A K + E N + RE M V H N++ + +
Sbjct: 19 IGQGVSALVHRALCIPFDEVVAIKILDFERDNCDLNNISREAQTMMLVD-HPNVLKSHCS 77
Query: 232 FYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVL 291
F + + + ++M YM GS IL D F E ++ I L
Sbjct: 78 FVSD---HNLWVIMPYMSGGSCLHILKAAYPD-------------GFEEAIIATILREAL 121
Query: 292 NGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINS-----LADTFVGTSTY 346
GL YL+ + IHRD+K NIL+ ++G VK+ DFGVS L +S +TFVGT +
Sbjct: 122 KGLDYLHQ-HGHIHRDVKAGNILLGARGAVKLGDFGVSACLFDSGDRQRTRNTFVGTPCW 180
Query: 347 MSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLS 406
D+WS G+ +EL+ G P + P K
Sbjct: 181 --------------ADIWSFGITGLELAHGHAPFSKY-----------------PPMKSF 209
Query: 407 KNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNNRDTIAKEFRHWCKKVKKRI 466
K + C +K+ R S K+L+ H F + + D IA++ + R+
Sbjct: 210 K---------QMIASCLVKDPSKRPSAKKLLKHSFFKQARSSDYIARKLLDGLPDLVNRV 260
Query: 467 KEDK 470
+ K
Sbjct: 261 QAIK 264
>7297776 [D] KOG0580 Serine/threonine protein kinase
Length = 329
Score = 84.7 bits (208), Expect = 3e-16
Identities = 73/273 (26%), Positives = 122/273 (43%), Gaps = 28/273 (10%)
Query: 172 IGAGNSGTVVKTLHVPDSRIIAKKTIPVEN--KEVLKNQLVRELTIMKNVSAHDNIVGFY 229
+G G G V ++A K + E K ++ Q++RE+ I + H +I+
Sbjct: 59 LGRGKFGRVYLARERHSHYLVAMKVMFKEELRKGCVQRQVLREIEIQSRLK-HPHILRLL 117
Query: 230 GAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFC 289
F++ S I + +E G L K L + HR F+E ++ ++
Sbjct: 118 TWFHDES---RIYLALEIASEGELFKHLR--GAPNHR-----------FDEPRSAKYTYQ 161
Query: 290 VLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTLINSLADTFVGTSTYMSP 349
V N L Y + +IHRD+KP NIL+ S D+K+ DFG S N+ T GT Y+ P
Sbjct: 162 VANALNYCH-LNNVIHRDLKPENILLTSTDDLKLADFGWSAHTPNNKRRTLCGTLDYLPP 220
Query: 350 ERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPKLSKNE 409
E + G Y D W LG++ E G P ++ E ++R+ ++S
Sbjct: 221 EMVDGNSYDDSVDQWCLGILCYEFVVGCPPF--ESNSTESTYSKIRRM------EISYPS 272
Query: 410 HYSIEMTDFVNRCCIKEERGRSSLKELICHDFI 442
H S + + KE +GR +L +++ H ++
Sbjct: 273 HLSKGCKELIGGLLRKESKGRITLVDVMTHYWV 305
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 84.7 bits (208), Expect = 3e-16
Identities = 77/282 (27%), Positives = 131/282 (46%), Gaps = 35/282 (12%)
Query: 171 KIGAGNSGTVVKTLHVPDSRIIAKKTIPV------ENKEVLKNQLVRELTIMKNVSAHDN 224
+IG G + + V ++A K + E +EV++ L E+ +M +++ H N
Sbjct: 25 QIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVE-ALREEIRMMSHLN-HPN 82
Query: 225 IVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLS 284
I+ GA S N + +E+M GS+ +LS Y + F E +
Sbjct: 83 IIRMLGATCEKSNYN---LFIEWMAGGSVAHLLSKYGA---------------FKESVVI 124
Query: 285 RISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGD-VKICDFGVSTTLINS------LA 337
+ +L GL YL++ +IIHRD+K +N+LI+S G ++I DFG + L +
Sbjct: 125 NYTEQLLRGLSYLHE-NQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQ 183
Query: 338 DTFVGTSTYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRI 397
+GT +M+PE ++G +Y DVWS+G IIE++ + P + L + + I
Sbjct: 184 GQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLAL-IFKVI 242
Query: 398 VNEPAPKLSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICH 439
+ S H S + D RC + + R +EL+ H
Sbjct: 243 IASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKH 284
>Hs21040235 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 384
Score = 84.3 bits (207), Expect = 4e-16
Identities = 67/254 (26%), Positives = 126/254 (49%), Gaps = 26/254 (10%)
Query: 167 VRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIV 226
+ L K+G G+ TV K + + +++A K I + +E + +RE +++K + H NIV
Sbjct: 53 LNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLK-HANIV 111
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
+ + T + + EYM L + +S + H NV +
Sbjct: 112 LLHDIIHTKET---LTFVFEYMHT-DLAQYMSQHPGGLHPHNVRL--------------F 153
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGV--STTLINSLADTFVGTS 344
F +L GL Y++ + ++HRD+KP N+LI+ G++K+ DFG+ + ++ + + V T
Sbjct: 154 MFQLLRGLAYIHHQH-VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTL 212
Query: 345 TYMSPERIQGG-RYTTKGDVWSLGLMIIELSSGE--FP-LGGHHDTPEGILDLLQRIVNE 400
Y P+ + G Y+++ D+W G + IE+ G+ FP + + E I ++L +
Sbjct: 213 WYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTED 272
Query: 401 PAPKLSKNEHYSIE 414
P +SK +Y+ E
Sbjct: 273 TWPGVSKLPNYNPE 286
>At5g42120 [T] KOG1187 Serine/threonine protein kinase
Length = 691
Score = 84.3 bits (207), Expect = 4e-16
Identities = 76/263 (28%), Positives = 123/263 (45%), Gaps = 28/263 (10%)
Query: 132 GVSMMQQETDETATLTTQIARLSL----TPENGIQLENLVRLSKIGAGNSGTVVKTLHVP 187
G + +E D + L RLSL + +G EN + +G G S TV + +P
Sbjct: 333 GKKRISEEADSNSGLVRMPGRLSLAEIKSATSGFN-ENAI----VGQGASATVYRG-SIP 386
Query: 188 DSRIIAKKTIPVEN-KEVLKNQLVRELTIMKNVSAHDNIVGFYGAFYNPSTTNEIVILME 246
+A K E+ + +N E T M H N+V F G S E ++ E
Sbjct: 387 SIGSVAVKRFDREHWPQCNRNPFTTEFTTMTGYLRHKNLVQFQGWC---SEGTETALVFE 443
Query: 247 YMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRISFCVLNGLIYLYD-CYK-II 304
Y+ GSL + L S + + + SW + I V + L YL++ C + II
Sbjct: 444 YLPNGSLSEFLHKKPSSDPSEEIIV---LSWKQRV---NIILGVASALTYLHEECERQII 497
Query: 305 HRDIKPSNILINSKGDVKICDFGV------STTLINSLADTFVGTSTYMSPERIQGGRYT 358
HRD+K NI+++++ + K+ DFG+ S L A GT Y++PE + G +
Sbjct: 498 HRDVKTCNIMLDAEFNAKLGDFGLAEIYEHSALLAGRAATLPAGTMGYLAPEYVYTGVPS 557
Query: 359 TKGDVWSLGLMIIELSSGEFPLG 381
K DV+S G++++E+ +G P+G
Sbjct: 558 EKTDVYSFGVVVLEVCTGRRPVG 580
>7296450 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 769
Score = 84.3 bits (207), Expect = 4e-16
Identities = 79/283 (27%), Positives = 128/283 (44%), Gaps = 37/283 (13%)
Query: 172 IGAGNSGTVVKT--LHVPDS---RIIAKKTIPVENKEVLKNQLVRELTIMKNVSAHDNIV 226
+G G TV K LH ++I KK I L N++ +E+ I + H +++
Sbjct: 20 LGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTG---LTNRVRQEVEIHSRLK-HPSVL 75
Query: 227 GFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCKTSWFNEMPLSRI 286
Y F + N + +++E G L + Y + R F E + I
Sbjct: 76 QLYTFFQD---ANYVYLVLELAHNGELHR----YMNHIARP----------FTETEAASI 118
Query: 287 SFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGVSTTL--INSLADTFVGTS 344
V+ GL+YL+ + I+HRDI SN+L++ + VKI DFG++T L + T GT
Sbjct: 119 LKQVVAGLLYLHS-HNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTP 177
Query: 345 TYMSPERIQGGRYTTKGDVWSLGLMIIELSSGEFPLGGHHDTPEGILDLLQRIVNEPAPK 404
Y+SPE + + DVWS+G M+ L G P + + L ++V +
Sbjct: 178 NYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRPPF-----ETDAVQSTLNKVV---MSE 229
Query: 405 LSKNEHYSIEMTDFVNRCCIKEERGRSSLKELICHDFICKYNN 447
H S E D +N+ K R +L+ ++CH F+ K +N
Sbjct: 230 YIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSN 272
>YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 560
Score = 84.0 bits (206), Expect = 5e-16
Identities = 86/321 (26%), Positives = 137/321 (41%), Gaps = 50/321 (15%)
Query: 163 LENLVRLSKIGAGNSGTVVKTLHVPDSRIIAKKTIPVENK--------EVLKNQLVRELT 214
L N L+ +G G G V + ++A K + K +V ++ +E+
Sbjct: 47 LNNFEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIE 106
Query: 215 IMKNVSAHDNIVGFYGAFYNPSTTNEIVILMEYMDCGSLDKILSVYRSDCHRKNVSISCK 274
+MK H+N+V Y +P +T ++ +++EY G + C + I
Sbjct: 107 VMKRCH-HENVVELYEILNDPEST-KVYLVLEYCSRGPVKW--------CPENKMEIKAV 156
Query: 275 TSWFNEMPLSR-ISFCVLNGLIYLYDCYKIIHRDIKPSNILINSKGDVKICDFGV----- 328
SR + V++GL YL+ I HRDIKPSN+LI+S G VKI DFGV
Sbjct: 157 GPSILTFQQSRKVVLDVVSGLEYLHS-QGITHRDIKPSNLLISSNGTVKISDFGVAMSTA 215
Query: 329 --STTLINS----LADTFVGTSTYMSPERIQGGR-YTTKG--DVWSLGLMIIELSSGEFP 379
ST + +S L +GT + +PE + Y+ D+WSLG+ I L G+ P
Sbjct: 216 TGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLP 275
Query: 380 LGGHHDTPEGILDLLQRIVNEPAPKLSKNEHYS-----------IEMTDFVNRCCIKEER 428
+ L+L I+N+P S E + + D + + K+
Sbjct: 276 FNANSG-----LELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPD 330
Query: 429 GRSSLKELICHDFICKYNNRD 449
R L ++ H F+C Y D
Sbjct: 331 KRIKLADIKVHPFMCHYGKSD 351
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,354,075
Number of Sequences: 60738
Number of extensions: 1206011
Number of successful extensions: 8196
Number of sequences better than 1.0e-05: 1580
Number of HSP's better than 0.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 1509
Number of HSP's that attempted gapping in prelim test: 5772
Number of HSP's gapped (non-prelim): 1793
length of query: 504
length of database: 30,389,216
effective HSP length: 111
effective length of query: 393
effective length of database: 23,647,298
effective search space: 9293388114
effective search space used: 9293388114
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)