ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4204 good L KOG2228 Replication, recombination and repair Origin recognition complex, subunit 4
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4204 1483650 1482007 -548
(548 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPR162c [L] KOG2228 Origin recognition complex subunit 4 387 e-107
SPBP23A10.13 [L] KOG2228 Origin recognition complex subunit 4 143 8e-34
Hs4505523 [L] KOG2228 Origin recognition complex subunit 4 130 5e-30
Hs20535209 [L] KOG2228 Origin recognition complex subunit 4 130 5e-30
7291857 [L] KOG2228 Origin recognition complex subunit 4 99 1e-20
>YPR162c [L] KOG2228 Origin recognition complex subunit 4
Length = 529
Score = 387 bits (993), Expect = e-107
Identities = 219/528 (41%), Positives = 312/528 (58%), Gaps = 34/528 (6%)
Query: 41 PVKRSSIGASNDSELDTAVVTKKTRTEDTAAQPIPLFGINKTPETKTFKRMKHYLTRKLN 100
P+KR S + + E A++ K+T + P FG ++ L ++L
Sbjct: 16 PIKRHS---NEEVEETAAILKKRTIDNEKCKDSDPGFG-----------SLQRRLLQQLY 61
Query: 101 GTLGFKETKIPDFLENTSTQVDKLLRQCIIQKESHSAILIGPRSNYKDMIIKHHLEALRS 160
GTL E I +L++ ++D++++Q IIQKESHS IL+GPR +YK ++ + L L+
Sbjct: 62 GTLPTDEKIIFTYLQDCQQEIDRIIKQSIIQKESHSVILVGPRQSYKTYLLDYELSLLQQ 121
Query: 161 THNEQFIVINLNGSLHSENSAINSIAEQLEFELANRNVNSSKKVKAXXXXXXXXXXXXVF 220
++ EQFI I LNG +HSE +AIN IA QLE +L + + K VF
Sbjct: 122 SYKEQFITIRLNGFIHSEQTAINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEVF 181
Query: 221 DNILRLLDSFTVTPLKGVHS-QKEKSEHVTLVFIFDEIDKFAGPVRQTLLYNLFDLVETS 279
+ IL LLDS T T + +E +T+VFIFDEID FAGPVRQTLLYNLFD+VE S
Sbjct: 182 EKILLLLDSTTKTRNEDSGEVDRESITKITVVFIFDEIDTFAGPVRQTLLYNLFDMVEHS 241
Query: 280 RIPVCVLGLTTKLAIMQFLENRVKSRFSQRIIYMPSISDYDQFKHVFKELLEVDDSTIPD 339
R+PVC+ G TTKL I+++LE RVKSRFSQR+IYMP I + D + LL V P
Sbjct: 242 RVPVCIFGCTTKLNILEYLEKRVKSRFSQRVIYMPQIQNLDDMVDAVRNLLTVRSEISPW 301
Query: 340 QLRWNQFLDETLKNDDSEISRILRQNYENFKDIQLLQNAIFPTVALSKTYSELVESIKTC 399
+WN+ L++ L + S ++R +R N+E F+ + L+N+I P VA SK + L +IK+C
Sbjct: 302 VSQWNETLEKELSDPRSNLNRHIRMNFETFRSLPTLKNSIIPLVATSKNFGSLCTAIKSC 361
Query: 400 SKIKKYLANQLLDSISAKILSLSDLELAILISACRVALK-NDEHINLTLVHEEFSKLGK- 457
S + Y NQL ++++ ++ SLSDLELAILISA RVAL+ D N L + E+ K+ K
Sbjct: 362 SFLDIYNKNQLSNNLTGRLQSLSDLELAILISAARVALRAKDGSFNFNLAYAEYEKMIKA 421
Query: 458 ---------------IHKTTFA--DRFKMWTKHDMKNVWENLANQELITERGAISVRFTE 500
++TF+ + K+W K D+KNVWENL + TE+ A+ +R
Sbjct: 422 INSRIPTVAPTTNVGTGQSTFSIDNTIKLWLKKDVKNVWENLVQLDFFTEKSAVGLRDNA 481
Query: 501 DSAIQSANYNSSTMKAPFDLRTYQVCVTLQEMRLTIPKSSFFYSWTQL 548
+A ++NY PFDLR+YQ+ + LQE+R IPKS+ +YSWTQL
Sbjct: 482 TAAFYASNYQFQGTMIPFDLRSYQMQIILQELRRIIPKSNMYYSWTQL 529
>SPBP23A10.13 [L] KOG2228 Origin recognition complex subunit 4
Length = 972
Score = 143 bits (360), Expect = 8e-34
Identities = 105/387 (27%), Positives = 190/387 (48%), Gaps = 42/387 (10%)
Query: 119 TQVDKLLRQCIIQKESHSAILIGPRSNYKDMIIKHHLEALRSTHNEQFIVINLNGSLHSE 178
T++ + +RQ I+ E +S I++GPR + K +++ L NE+ V+ LNG+ ++
Sbjct: 560 TKLYQWVRQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQEINEKSYVVRLNGTYQTD 619
Query: 179 NS-AINSIAEQLEFELANRNVNSSKKVKAXXXXXXXXXXXXVFDNILRLLDSFTVTPLKG 237
+ A+ I+ QL EL ++ S + +K+ D + +LL + + G
Sbjct: 620 DKLALREISRQLSIEL--ESIESDEALKSEMNFS---------DTLTKLLATLSHPVDLG 668
Query: 238 VHSQKEKSEHVTLVFIFDEIDKFAGPVRQTLLYNLFDLVETSRIPVCVLGLTTKLAIMQF 297
+ ++ + ++F+ +E D F RQ LLYNLFD+ ++ + P+ ++GLTT+ +
Sbjct: 669 I-AEDVMTTSAAVIFVLEEFDLFVQHSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSES 727
Query: 298 LENRVKSRFSQRIIYMPSISDYDQFKHVFKELLEVDDSTIPDQL--RWNQFLDETLKNDD 355
LE RVKSRFS +I M S +F+ + K +L V D DQ+ WNQ +DE L +
Sbjct: 728 LEKRVKSRFSHMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTR 787
Query: 356 SEISRILRQNYENFKDIQLLQNAIFPTVALSKTYSELVESIKTCSKIKKYLANQLLDSIS 415
S + ++++ +Y ++++LL Y +L+ I + + + LA++ +IS
Sbjct: 788 SHLHKLVQHHYFASRNLKLL-------------YVDLLFPILSMAPDRPLLADEDFANIS 834
Query: 416 AK--------ILSLSDLELAILISACRVALKNDEHINLTLVHEEF------SKLGKIHKT 461
K + +LS LELA+LI A R ++ N ++E+ S +
Sbjct: 835 LKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEYRQLHQSSVINAAASG 894
Query: 462 TFADRFKMWTKHDMKNVWENLANQELI 488
A ++W + WE L + LI
Sbjct: 895 ALAHSSRLWGRDVALEAWETLGSIGLI 921
>Hs4505523 [L] KOG2228 Origin recognition complex subunit 4
Length = 436
Score = 130 bits (327), Expect = 5e-30
Identities = 102/347 (29%), Positives = 179/347 (51%), Gaps = 51/347 (14%)
Query: 121 VDKLLRQCIIQKESHSAILIGPRSNYKDMIIKHHLEALRSTH--NEQFIVINLNGSLH-S 177
+ +LL++ + ES+S ++IGPR + K M+I H L+ L +E + ++LNG L +
Sbjct: 47 LSELLKRTALHGESNSVLIIGPRGSGKTMLISHALKELMEIEEVSENVLQVHLNGLLQIN 106
Query: 178 ENSAINSIAEQLEFELANRNVNSSKKVKAXXXXXXXXXXXXVFDNILRLLDSFTVTPLKG 237
+ A+ I QL E NV K VF + L SF + LK
Sbjct: 107 DKIALKEITRQLNLE----NVVGDK----------------VFGSFAENL-SFLLEALK- 144
Query: 238 VHSQKEKSEHVTLVFIFDEIDKFAGPVRQTLLYNLFDLVETSRIPVCVLGLTTKLAIMQF 297
+ +++ ++FI DE D FA QTLLYNLFD+ ++++ P+ V+GLT +L I++
Sbjct: 145 ---KGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILEL 201
Query: 298 LENRVKSRFSQRIIYMPSISDYDQFKHVFKELLEVDDSTIPDQL---RWNQFLDETLKND 354
LE RVKSRFS R I++ + + Q+ +FKE L + + PD++ +WN+ + ++
Sbjct: 202 LEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSL-PAEFPDKVFAEKWNE--NVQYLSE 258
Query: 355 DSEISRILRQNY---ENFKDIQLLQNAIFPTVALS---KTYSELVESIKTCSKIKKYLAN 408
D + +L++++ +N + + +L V S T +L+E+ + CS
Sbjct: 259 DRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCS-------- 310
Query: 409 QLLDSISAKILSLSDLELAILISACRV-ALKNDEHINLTLVHEEFSK 454
+DS + + LS LE+ ++I+ + + +E N +V+ EF K
Sbjct: 311 --MDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQK 355
>Hs20535209 [L] KOG2228 Origin recognition complex subunit 4
Length = 436
Score = 130 bits (327), Expect = 5e-30
Identities = 102/347 (29%), Positives = 179/347 (51%), Gaps = 51/347 (14%)
Query: 121 VDKLLRQCIIQKESHSAILIGPRSNYKDMIIKHHLEALRSTH--NEQFIVINLNGSLH-S 177
+ +LL++ + ES+S ++IGPR + K M+I H L+ L +E + ++LNG L +
Sbjct: 47 LSELLKRTALHGESNSVLIIGPRGSGKTMLINHALKELMEIEEVSENVLQVHLNGLLQIN 106
Query: 178 ENSAINSIAEQLEFELANRNVNSSKKVKAXXXXXXXXXXXXVFDNILRLLDSFTVTPLKG 237
+ A+ I QL E NV K VF + L SF + LK
Sbjct: 107 DKIALKEITRQLNLE----NVVGDK----------------VFGSFAENL-SFLLEALK- 144
Query: 238 VHSQKEKSEHVTLVFIFDEIDKFAGPVRQTLLYNLFDLVETSRIPVCVLGLTTKLAIMQF 297
+ +++ ++FI DE D FA QTLLYNLFD+ ++++ P+ V+GLT +L I++
Sbjct: 145 ---KGDRTSSCPVIFILDEFDLFAHHKNQTLLYNLFDISQSAQTPIAVIGLTCRLDILEL 201
Query: 298 LENRVKSRFSQRIIYMPSISDYDQFKHVFKELLEVDDSTIPDQL---RWNQFLDETLKND 354
LE RVKSRFS R I++ + + Q+ +FKE L + + PD++ +WN+ + ++
Sbjct: 202 LEKRVKSRFSHRQIHLMNSFGFPQYVKIFKEQLSL-PAEFPDKVFAEKWNE--NVQYLSE 258
Query: 355 DSEISRILRQNY---ENFKDIQLLQNAIFPTVALS---KTYSELVESIKTCSKIKKYLAN 408
D + +L++++ +N + + +L V S T +L+E+ + CS
Sbjct: 259 DRSVQEVLQKHFNISKNLRSLHMLLMLALNRVTASHPFMTAVDLMEASQLCS-------- 310
Query: 409 QLLDSISAKILSLSDLELAILISACRV-ALKNDEHINLTLVHEEFSK 454
+DS + + LS LE+ ++I+ + + +E N +V+ EF K
Sbjct: 311 --MDSKANIVHGLSVLEICLIIAMKHLNDIYEEEPFNFQMVYNEFQK 355
>7291857 [L] KOG2228 Origin recognition complex subunit 4
Length = 459
Score = 99.4 bits (246), Expect = 1e-20
Identities = 69/220 (31%), Positives = 120/220 (54%), Gaps = 34/220 (15%)
Query: 119 TQVDKLLRQCIIQKESHSAILIGPRSNYKDMIIKHHLEAL--RSTHNEQFIVINLNGSLH 176
+ V LL++ ES+S +L+GPR + K +I L L + E ++++L+G+LH
Sbjct: 34 SNVRLLLQRTAEMGESNSLLLLGPRGSGKTTLINSVLADLLPNKSFGENTLIVHLDGNLH 93
Query: 177 SENS-AINSIAEQLEFELANRNVNSSKKVKAXXXXXXXXXXXXVFDNILRLLDSFTVTPL 235
+++ A+ SI Q++ E A VF + L +F + L
Sbjct: 94 TDDRVALKSITVQMQLENA--------------------ADGKVFGSFAENL-AFLLQCL 132
Query: 236 K--GVHSQKEKSEHVTLVFIFDEIDKFAGPVRQTLLYNLFDLVETSRIPVCVLGLTTKLA 293
K G HS+ +++FI +E D F QTLLYNLFD+ ++++ P+CVLG+T +L
Sbjct: 133 KAGGKHSK-------SVIFILEEFDLFCAHHNQTLLYNLFDVSQSAQAPICVLGVTCRLD 185
Query: 294 IMQFLENRVKSRFSQRIIYM-PSISDYDQFKHVFKELLEV 332
+++ LE RVKSRFS R +++ PS+ ++ + + ++LL +
Sbjct: 186 VIELLEKRVKSRFSHRQVFLFPSLRRFEDYVDLCRDLLSL 225
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.133 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,544,461
Number of Sequences: 60738
Number of extensions: 1188032
Number of successful extensions: 3746
Number of sequences better than 1.0e-05: 5
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 3733
Number of HSP's gapped (non-prelim): 6
length of query: 548
length of database: 30,389,216
effective HSP length: 111
effective length of query: 437
effective length of database: 23,647,298
effective search space: 10333869226
effective search space used: 10333869226
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)