ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4213 good R KOG1729 General function prediction only FYVE finger containing protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4213 1486968 1484998 -657
(657 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGL023c [R] KOG1729 FYVE finger containing protein 214 3e-55
SPBC9B6.03 [R] KOG1729 FYVE finger containing protein 63 2e-09
7302711 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase an... 58 4e-08
YNR006w [TU] KOG1818 Membrane trafficking and cell signaling pro... 57 7e-08
YFR019w [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase an... 56 2e-07
Hs7662048 [V] KOG1841 Smad anchor for receptor activation 55 3e-07
Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and... 55 3e-07
At1g20110 [R] KOG1729 FYVE finger containing protein 55 3e-07
CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 53 2e-06
Hs6552339 [V] KOG1841 Smad anchor for receptor activation 52 2e-06
Hs6552337 [V] KOG1841 Smad anchor for receptor activation 52 2e-06
Hs4759060 [V] KOG1841 Smad anchor for receptor activation 52 2e-06
Hs13376757 [R] KOG1729 FYVE finger containing protein 52 3e-06
7301552 [R] KOG1819 FYVE finger-containing proteins 52 3e-06
7301558_1 [T] KOG4381 RUN domain-containing protein 50 8e-06
>YGL023c [R] KOG1729 FYVE finger containing protein
Length = 635
Score = 214 bits (545), Expect = 3e-55
Identities = 154/454 (33%), Positives = 212/454 (45%), Gaps = 86/454 (18%)
Query: 268 KQNKLTTDALRKLS-----------LLQQSKGAVCKSVQTTPLTSS-----ENLVDP--- 308
+Q LTT ALRKLS L +++K S T+ ++SS EN+VD
Sbjct: 204 RQKNLTTQALRKLSSFKMNASSNLRLSKENKAKESSSSSTSSVSSSSTSKVENIVDKLTT 263
Query: 309 --KEPLTQLKFGGKNVILDTTATIRKNSVAMEASGDQNEARKQSLEIISQPTGVTLHGTS 366
++QL+FG NVI+D+ K Q RK SLE + QP T+
Sbjct: 264 TNSSSMSQLRFGNTNVIIDSVNHAAKPP-------HQQMLRKPSLEFLPQPAS----STN 312
Query: 367 HNFNEAKGICSNSTASSNSKRLLQQINEPKKPMYVPAVLRDISETNIKIEDLKSHSPTPS 426
NFN S+ K ++QI+ PKKP+Y+PAVLR +SETNI +DL + + +
Sbjct: 313 LNFN-----------SNKHKSNVRQISNPKKPLYIPAVLRKVSETNITNDDLLNATLSSY 361
Query: 427 DVTQTTLQAVL----SKHSNTSNSNYARXXXXXXXXXXXX------YRNKIQSWLC---- 472
+ L+ S+ ++ N+N R Y+NKI S+L
Sbjct: 362 YKKASNLEHGFNPSKSQSASVQNANNLRIISSQSSVQSNTSSILESYKNKISSYLFPNSI 421
Query: 473 -NERDLQL----------QLIQPTKEHWIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIF 521
N + L ++ PTK+HWIPDSKR+SC+YCHK FT WERKHHCRHCGDIF
Sbjct: 422 PNSDRINLIPTISNRNSARVNPPTKDHWIPDSKRNSCRYCHKPFTLWERKHHCRHCGDIF 481
Query: 522 CQQHVRHWLYLNPNAKFII-------GCGGLGVLSKICDSCLDEYDTLV----KAGPAKD 570
CQ H+RHWLYL+ A FI+ G G G L KICD CL EY+ L A +D
Sbjct: 482 CQDHLRHWLYLDSQANFIMINELNNGGINGGGTLCKICDDCLVEYENLSTTNHNANTNED 541
Query: 571 QAELXXXXXXXXXXXXXXXXXXHSGSIRXXXXXXSGNHSNTLLNLPKPAT-----GRNID 625
+ + + G S + + T N +
Sbjct: 542 NINVEEGEDDDNDNRKKLRNYYKNRQMNALFRPKKGGSSQEHATVDRDTTTPIQVKSNDE 601
Query: 626 EALNGTEGSVNQRQH--LENIVGSVPADWSWSSF 657
EA N G + + L +++GSVPA+W+WSSF
Sbjct: 602 EADNENTGGEQEEGNDVLGSVIGSVPANWNWSSF 635
Score = 63.5 bits (153), Expect = 1e-09
Identities = 54/157 (34%), Positives = 71/157 (44%), Gaps = 38/157 (24%)
Query: 32 RNGSETSIASMKSAKSTITFEKQKVVPRARTMSVQSVLSSFSLRSMLNTREHGGPQSQNC 91
R G E S A + S ITFEK+K+ PRA T S QS+LSS SL+SM+N +H Q Q
Sbjct: 40 RKGDEESGAD--TVTSPITFEKKKIAPRASTHSEQSILSSISLKSMVN--QHRQQQLQQ- 94
Query: 92 DEEECXXXXXXXXXXXXXXXXXXXXXXIATTFINPTQQIQSPAMASTMVKKRNGVAGKNK 151
T F++ QQIQSPAM S + R A +N
Sbjct: 95 ----------------------ESSTGAGTGFVDRKQQIQSPAMVSIL---RKNSAEENV 129
Query: 152 QTFLS--------DLPMTESRSRIGQQLPFNDDKRKS 180
++ S D + IG+ LPF DD+R +
Sbjct: 130 RSSHSSKLGEGQIDGRKASASKEIGKTLPFTDDQRSN 166
>SPBC9B6.03 [R] KOG1729 FYVE finger containing protein
Length = 293
Score = 62.8 bits (151), Expect = 2e-09
Identities = 31/77 (40%), Positives = 41/77 (52%), Gaps = 6/77 (7%)
Query: 485 TKEHWIPDSKRHSCKY--CHKIFTFWERKHHCRHCGDIFCQQHVRHWLYLNPNAKFIIGC 542
+K+HW PDS C + C F ++R+HHCR CGDIFC H + L + KF +
Sbjct: 147 SKDHWKPDSDVSVCSFPSCSVRFGLFDRRHHCRRCGDIFCALHCDRNIPLTMDVKFCLA- 205
Query: 543 GGLGVLSKICDSCLDEY 559
G L + C SC EY
Sbjct: 206 ---GSLYRSCVSCFYEY 219
>7302711 [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 1809
Score = 58.2 bits (139), Expect = 4e-08
Identities = 53/222 (23%), Positives = 95/222 (41%), Gaps = 32/222 (14%)
Query: 366 SHNFNEAKGICSNSTASSNSKRLL-----QQINEPKKPMYVPAVLRDISETNIKIE---- 416
+ ++N I S S++SS+++ + Q ++ + A + S+++++ +
Sbjct: 48 NQSYNTVNDISSGSSSSSSTQPVQVVGKSQFFSDSQTSTAEIADVETSSQSSVRPQPPTT 107
Query: 417 -DLKSHSPTPSDVTQTTLQAVLSKHSN--------TSNSNYARXXXXXXXXXXXXYRNKI 467
++++S T T + A S+ S+ TS +N R K
Sbjct: 108 LSIRTNSETRGTSTSSNTAAEDSETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKN 167
Query: 468 QSWLCNERDLQLQLIQPTKEHWIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFCQQHVR 527
+ L N +D +LQ W+PDSK C C + F+ + RKHHCR CG IFC +
Sbjct: 168 NNDLRNYKDTELQ------RFWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCN 221
Query: 528 HWLYLNPNAKFIIGCGGLGVLSKICDSCLDEYDTLVKAGPAK 569
+ II C G K+C+ C T +K+ ++
Sbjct: 222 QVV-----PGMIIRCDG---DLKVCNYCSKIVLTFLKSSSSE 255
>YNR006w [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 622
Score = 57.4 bits (137), Expect = 7e-08
Identities = 38/135 (28%), Positives = 56/135 (41%), Gaps = 15/135 (11%)
Query: 426 SDVTQTTLQAVLSKHSNTSNSNYARXXXXXXXXXXXXYRNKIQSWLCNERDLQLQLIQPT 485
S++ +T L + N S NY + K+ L N T
Sbjct: 111 SELVKTILYELYVAFKNDSQLNYVAKVYDKLISRGIKFPEKLT--LSNSPTAMFD--SKT 166
Query: 486 KEHWIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFCQQHVRHWLYLNPNAKFIIGCGGL 545
WI +C C K F+ RKHHCR CG +FCQ+H + + L P+ G+
Sbjct: 167 PADWIDSD---ACMICSKKFSLLNRKHHCRSCGGVFCQEHSSNSIPL-PDL-------GI 215
Query: 546 GVLSKICDSCLDEYD 560
++CDSC ++YD
Sbjct: 216 YEPVRVCDSCFEDYD 230
>YFR019w [T] KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related
FYVE finger-containing proteins
Length = 2278
Score = 56.2 bits (134), Expect = 2e-07
Identities = 35/136 (25%), Positives = 52/136 (37%), Gaps = 9/136 (6%)
Query: 485 TKEHWIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFCQQHVRHWLYLNPNAKFIIGCGG 544
+KE+W+ D C C K F + RKHHCR CG IFC L +F G
Sbjct: 233 SKEYWMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSS----CTLLIDGDRF-----G 283
Query: 545 LGVLSKICDSCLDEYDTLVKAGPAKDQAELXXXXXXXXXXXXXXXXXXHSGSIRXXXXXX 604
++C +C + DT + ++ + + +S S
Sbjct: 284 CHAKMRVCYNCYEHADTYEDSSDEENDSTMQLNEPRSRSRSRSSNTNPYSHSHSHLHLIS 343
Query: 605 SGNHSNTLLNLPKPAT 620
NH+ T L+ P AT
Sbjct: 344 QDNHNGTDLHDPVAAT 359
>Hs7662048 [V] KOG1841 Smad anchor for receptor activation
Length = 1539
Score = 55.5 bits (132), Expect = 3e-07
Identities = 62/244 (25%), Positives = 96/244 (38%), Gaps = 23/244 (9%)
Query: 294 VQTTPLTS-SENLVDPKEPLTQLKFGG------KNVILDTTATIRKNSVAMEA---SGDQ 343
+QTT + S EN+ D K + Q+ G N+ + A S + + D+
Sbjct: 542 LQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGINIICETVDK 601
Query: 344 NEARKQSLEIISQPTGVTLHGTSHNFNEAKGICSNSTASSNSKRLLQQINEPKKPMYVPA 403
+ L + + T G + +E S S +S S + PK+ +P+
Sbjct: 602 QNTIENGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSVGGAR----PKQLFSLPS 657
Query: 404 VLRDISETNIK-IEDLKSHSPTPSDVTQTTLQAVLSKHSN--TSNSNYARXXXXXXXXXX 460
R + N + D P+ +D A+ S + NSNY
Sbjct: 658 RTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSEGGSS 717
Query: 461 XXYRNK--IQSWLCNERDLQLQLIQPTKEHWIPDSKRHSCKYCHKIFTFWERKHHCRHCG 518
N+ + C E L L QPT W+PDS+ +C C FTF +R+HHCR CG
Sbjct: 718 FVTANEDSVPENTCKE-GLVLGQKQPT---WVPDSEAPNCMNCQVKFTFTKRRHHCRACG 773
Query: 519 DIFC 522
+FC
Sbjct: 774 KVFC 777
>Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 1513
Score = 55.5 bits (132), Expect = 3e-07
Identities = 48/216 (22%), Positives = 88/216 (40%), Gaps = 34/216 (15%)
Query: 336 AMEASGDQNEARKQSL-----EIISQPTGVTLHGTSHNFNEAKGICSNSTASSNSKRLLQ 390
A + +EA +QS+ + SQP+ + + + C++S S +S+R
Sbjct: 1265 AQDEDSSDSEADEQSISQDPKDTPSQPSSTSHRPRAASCRATAAWCTDS-GSDDSRRWSD 1323
Query: 391 QINEPKKPMYVPAVLRDISETNIKIEDLKSHS-PTPSDVT-------------QTTLQAV 436
Q++ +K ++ V +T ++ SH P P +V Q ++
Sbjct: 1324 QLSLDEKDGFI-FVNYSEGQTRAHLQGPLSHPHPNPIEVRNYSRLKPGYRWERQLVFRSK 1382
Query: 437 LSKHSNTSNSNYARXXXXXXXXXXXXY--------RNKIQSWLCNERDLQLQLIQPTKEH 488
L+ H+ + A + R ++ SW ++ Q + +H
Sbjct: 1383 LTMHTAFDRKDNAHPAEVTALGISKDHSRILVGDSRGRVFSWSVSD-----QPGRSAADH 1437
Query: 489 WIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFCQQ 524
W+ D SC C F+ ER+HHCR+CG +FCQ+
Sbjct: 1438 WVKDEGGDSCSGCSVRFSLTERRHHCRNCGQLFCQK 1473
>At1g20110 [R] KOG1729 FYVE finger containing protein
Length = 613
Score = 55.1 bits (131), Expect = 3e-07
Identities = 28/85 (32%), Positives = 42/85 (48%), Gaps = 15/85 (17%)
Query: 479 LQLIQPT---KEHWIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFCQQ--HVRHWLYLN 533
+ +I+P K+HW+PD C C F + R+HHCR+CGD+FC + R L
Sbjct: 439 MNIIKPVNEEKDHWVPDEAVSKCTSCGSDFGAFIRRHHCRNCGDVFCDKCTQGRIALTAE 498
Query: 534 PNAKFIIGCGGLGVLSKICDSCLDE 558
NA + ++CD C+ E
Sbjct: 499 DNAPQV----------RVCDRCMAE 513
>CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 931
Score = 52.8 bits (125), Expect = 2e-06
Identities = 19/36 (52%), Positives = 23/36 (63%)
Query: 487 EHWIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFC 522
+HW+ D R C C FT +RKHHCR+CG IFC
Sbjct: 858 DHWVQDVTRQRCDDCEHKFTLADRKHHCRNCGQIFC 893
>Hs6552339 [V] KOG1841 Smad anchor for receptor activation
Length = 1210
Score = 52.4 bits (124), Expect = 2e-06
Identities = 18/34 (52%), Positives = 24/34 (69%)
Query: 489 WIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFC 522
W+PDS+ +C C FTF +R+HHCR CG +FC
Sbjct: 696 WVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFC 729
>Hs6552337 [V] KOG1841 Smad anchor for receptor activation
Length = 762
Score = 52.4 bits (124), Expect = 2e-06
Identities = 18/34 (52%), Positives = 24/34 (69%)
Query: 489 WIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFC 522
W+PDS+ +C C FTF +R+HHCR CG +FC
Sbjct: 696 WVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFC 729
>Hs4759060 [V] KOG1841 Smad anchor for receptor activation
Length = 1323
Score = 52.4 bits (124), Expect = 2e-06
Identities = 18/34 (52%), Positives = 24/34 (69%)
Query: 489 WIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFC 522
W+PDS+ +C C FTF +R+HHCR CG +FC
Sbjct: 594 WVPDSQAPNCMKCEARFTFTKRRHHCRACGKVFC 627
>Hs13376757 [R] KOG1729 FYVE finger containing protein
Length = 310
Score = 52.0 bits (123), Expect = 3e-06
Identities = 27/74 (36%), Positives = 36/74 (48%), Gaps = 11/74 (14%)
Query: 483 QPTKEH-WIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFCQQHVRHWLYLNPNAKFIIG 541
Q K H W+ D + C+ C K F+ RKHHCR+CG IFC + L L K +
Sbjct: 234 QALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPV-- 291
Query: 542 CGGLGVLSKICDSC 555
++CDSC
Sbjct: 292 --------RVCDSC 297
>7301552 [R] KOG1819 FYVE finger-containing proteins
Length = 920
Score = 52.0 bits (123), Expect = 3e-06
Identities = 43/197 (21%), Positives = 81/197 (40%), Gaps = 33/197 (16%)
Query: 338 EASGDQNEA-----RKQSLEIISQP-----TGVTLHGTSHNFNEAKGICSNSTASS--NS 385
+A+G ++ A R ++++ SQP +G T + + ++ + ASS +S
Sbjct: 695 QATGQRHSAGASMQRNNTIDLASQPGEGSPSGATTATSRSHVTRSRSLGDQEAASSATSS 754
Query: 386 KRLLQQINEPKKPMYVPAVLRDISETNIKIEDLKSHSPTPSDVTQTTLQAVLSKHSNTSN 445
L+Q+ + ++ + L+ ++ S TPS S+TS+
Sbjct: 755 TAQLRQLEQQQQQQQLQIQLQRQRNNSVG-------SNTPSSA------------SSTSS 795
Query: 446 SNYARXXXXXXXXXXXXYRNKIQSWLCNERDLQLQLIQPTKEHWIPDSKRHSCKYCHKIF 505
S+ ++ ++ + + + P WIPD K C C F
Sbjct: 796 SSEQNSPVSARSGSRRRLQSNNETQMPSSATSTSATLSPPA--WIPDGKAPRCMACQTPF 853
Query: 506 TFWERKHHCRHCGDIFC 522
T + R+HHCR+CG +FC
Sbjct: 854 TAFRRRHHCRNCGGVFC 870
>7301558_1 [T] KOG4381 RUN domain-containing protein
Length = 951
Score = 50.4 bits (119), Expect = 8e-06
Identities = 21/44 (47%), Positives = 24/44 (53%)
Query: 489 WIPDSKRHSCKYCHKIFTFWERKHHCRHCGDIFCQQHVRHWLYL 532
W PDS C C + F RKHHCR CG+IFC+ H L L
Sbjct: 860 WAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPL 903
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.312 0.127 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,988,660
Number of Sequences: 60738
Number of extensions: 1197061
Number of successful extensions: 4001
Number of sequences better than 1.0e-05: 15
Number of HSP's better than 0.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3971
Number of HSP's gapped (non-prelim): 20
length of query: 657
length of database: 30,389,216
effective HSP length: 113
effective length of query: 544
effective length of database: 23,525,822
effective search space: 12798047168
effective search space used: 12798047168
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)