ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4303 good CE KOG0453 Amino acid transport and metabolism Aconitase/homoaconitase (aconitase superfamily)
r_klactIII4303 good CE KOG0453 Energy production and conversion Aconitase/homoaconitase (aconitase superfamily)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4303 1519028 1521391 788
(788 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR304c [CE] KOG0453 Aconitase/homoaconitase (aconitase superfam... 1312 0.0
SPAC24C9.06c [CE] KOG0453 Aconitase/homoaconitase (aconitase sup... 1045 0.0
CE25005 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfam... 1001 0.0
Hs4501867 [CE] KOG0453 Aconitase/homoaconitase (aconitase superf... 967 0.0
7299398 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfam... 930 0.0
7298762 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfam... 891 0.0
YJL200c [CE] KOG0453 Aconitase/homoaconitase (aconitase superfam... 752 0.0
SPBP4H10.15 [CE] KOG0453 Aconitase/homoaconitase (aconitase supe... 719 0.0
Hs17489116 [CE] KOG0453 Aconitase/homoaconitase (aconitase super... 470 e-132
Hs22051976 [CE] KOG0453 Aconitase/homoaconitase (aconitase super... 274 4e-73
Hs22068703 [CE] KOG0453 Aconitase/homoaconitase (aconitase super... 263 1e-69
Hs8659555 [AJ] KOG0452 RNA-binding translational regulator IRP (... 192 2e-48
At4g35830 [AJ] KOG0452 RNA-binding translational regulator IRP (... 179 1e-44
At4g26970 [AJ] KOG0452 RNA-binding translational regulator IRP (... 178 3e-44
At2g05710 [AJ] KOG0452 RNA-binding translational regulator IRP (... 173 1e-42
CE03812 [AJ] KOG0452 RNA-binding translational regulator IRP (ac... 172 2e-42
7300911 [AJ] KOG0452 RNA-binding translational regulator IRP (ac... 166 1e-40
7299336 [AJ] KOG0452 RNA-binding translational regulator IRP (ac... 155 3e-37
Hs17478037 [AJ] KOG0452 RNA-binding translational regulator IRP ... 151 4e-36
SPAC343.16 [CE] KOG0453 Aconitase/homoaconitase (aconitase super... 142 2e-33
YDR234w [CE] KOG0453 Aconitase/homoaconitase (aconitase superfam... 142 2e-33
YGL009c [E] KOG0454 3-isopropylmalate dehydratase (aconitase sup... 117 5e-26
At4g13430 [E] KOG0454 3-isopropylmalate dehydratase (aconitase s... 106 2e-22
SPAC9E9.03 [E] KOG0454 3-isopropylmalate dehydratase (aconitase ... 94 1e-18
Hs17450976 [CE] KOG0453 Aconitase/homoaconitase (aconitase super... 70 2e-11
>YLR304c [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 778
Score = 1312 bits (3396), Expect = 0.0
Identities = 642/775 (82%), Positives = 692/775 (88%), Gaps = 8/775 (1%)
Query: 1 MLSARVALKKQGVVRQGVIRHLATGVSSTMTRDSKVHQNLLEDHSFINYKQNIEYVNIVR 60
MLSAR A+K+ ++R LAT S +TRDSKV+QNLLEDHSFINYKQN+E ++IVR
Sbjct: 1 MLSARSAIKRP------IVRGLAT--VSNLTRDSKVNQNLLEDHSFINYKQNVETLDIVR 52
Query: 61 ERLGRPLTYAEKILYGHLDDPHGQEIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLP 120
+RL RP TYAEKILYGHLDDPHGQ+I+RGVSYLKLRPDRVACQDATAQMAILQFMSAGLP
Sbjct: 53 KRLNRPFTYAEKILYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMSAGLP 112
Query: 121 QVAKPLTVHCDHLIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNMGFWKPGSGIIHQI 180
QVAKP+TVHCDHLIQAQ+GGEKDLKRAID+NKEVYDFLA+ATAKYNMGFWKPGSGIIHQI
Sbjct: 113 QVAKPVTVHCDHLIQAQVGGEKDLKRAIDLNKEVYDFLASATAKYNMGFWKPGSGIIHQI 172
Query: 181 VLENYAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTG 240
VLENYAFPGALIIGTDSHTPN DAVDVM+ WELKAPKI+GVKLTG
Sbjct: 173 VLENYAFPGALIIGTDSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTG 232
Query: 241 RMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSV 300
+MNGWTSPKDIILKLA EYFGDGVDTFSATGMGTICNMGAEIGATTSV
Sbjct: 233 KMNGWTSPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSV 292
Query: 301 FPFNKSMIDYLDATGRDKIAQFAQLYHKDLLSADEGAEYDEIIEIDLNTLEPYVNGPFTP 360
FPFNKSMI+YL+ATGR KIA FA+LYHKDLLSAD+ AEYDE++EIDLNTLEPY+NGPFTP
Sbjct: 293 FPFNKSMIEYLEATGRGKIADFAKLYHKDLLSADKDAEYDEVVEIDLNTLEPYINGPFTP 352
Query: 361 DLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAATHGLKSKSIFT 420
DLATP+SKMK+VAV NNWPL+V+VGLIGSCTNSSYEDMSR+AS+VKDAA HGLKSK+IFT
Sbjct: 353 DLATPVSKMKEVAVANNWPLDVRVGLIGSCTNSSYEDMSRSASIVKDAAAHGLKSKTIFT 412
Query: 421 VTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCIGQWDRQDIKKGDKNTIVSSFNRN 480
VTPGSEQIRATI RDGQLETFKEFGG VLANACGPCIGQWDR+DIKKGDKNTIVSS+NRN
Sbjct: 413 VTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQWDRRDIKKGDKNTIVSSYNRN 472
Query: 481 FTARNDGNPDTHSFVASPEITTAFAIAGDLRFNPLTDTLKDKDGNEFMLKPPTGVGLPVK 540
FT+RNDGNP TH+FVASPE+ TAFAIAGDLRFNPLTD LKDKDGNEFMLKPP G GLP +
Sbjct: 473 FTSRNDGNPQTHAFVASPELVTAFAIAGDLRFNPLTDKLKDKDGNEFMLKPPHGDGLPQR 532
Query: 541 GYDPGENTYQAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDGKDAFDMPILIKSLGKTTTD 600
GYD GENTYQAPP DRS+V V+VSPTSDRLQLLKPFK WDGKDA DMPILIK++GKTTTD
Sbjct: 533 GYDAGENTYQAPPADRSTVEVKVSPTSDRLQLLKPFKPWDGKDAKDMPILIKAVGKTTTD 592
Query: 601 HISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKHHYTGEYAGVPDTARAYRDAGI 660
HISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVK+ YTGEY GVPDTAR YRD GI
Sbjct: 593 HISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKNVYTGEYKGVPDTARDYRDQGI 652
Query: 661 RWVVIGGENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAY 720
+WVVIG ENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQG+LPLNF PA Y
Sbjct: 653 KWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNPADY 712
Query: 721 DKINPDDTIDILGLTTLAPGKNLIMRVHPKEGEAWETPLSHTFNAEQIEWFKAGS 775
DKINPDD IDILGL LAPGK + MRVHPK G+ W+ L+HTFN EQIEWFK GS
Sbjct: 713 DKINPDDRIDILGLAELAPGKPVTMRVHPKNGKPWDAVLTHTFNDEQIEWFKYGS 767
>SPAC24C9.06c [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 778
Score = 1045 bits (2703), Expect = 0.0
Identities = 513/767 (66%), Positives = 601/767 (77%), Gaps = 9/767 (1%)
Query: 13 VVRQGVIRHLATGVSSTMTRDSKVHQNLLEDHSFINYKQNIEYVNIVRERLGRPLTYAEK 72
+ Q +R + + KV + E + FINY++ + + IV++RL RPLTY+EK
Sbjct: 5 IFTQSTLRSFSCAPVAANIDAKKVAMSNFEKNKFINYQRIKDNLEIVKKRLNRPLTYSEK 64
Query: 73 ILYGHLDDPHGQEIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPLTVHCDH 132
ILYGHLDDP Q+IERGVSYLKLRPDRVACQDATAQMAILQFMSAG+P+VA P+TVHCDH
Sbjct: 65 ILYGHLDDPVNQDIERGVSYLKLRPDRVACQDATAQMAILQFMSAGMPEVAVPVTVHCDH 124
Query: 133 LIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNMGFWKPGSGIIHQIVLENYAFPGALI 192
LI+A GG DL+RA NKEVYDFL TA AKYN+GFW+PGSGIIHQIVLENYAFPG L+
Sbjct: 125 LIEAYEGGPIDLERANVTNKEVYDFLQTACAKYNIGFWRPGSGIIHQIVLENYAFPGGLL 184
Query: 193 IGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRMNGWTSPKDII 252
IGTDSHTPN DAVDVM++L WELK PK++GVKLTG++ GWTSPKD+I
Sbjct: 185 IGTDSHTPNAGGLGMVAIGVGGADAVDVMANLPWELKCPKVIGVKLTGQLKGWTSPKDVI 244
Query: 253 LKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIDYLD 312
LK+A EYFG GV++ S TGMGTICNMGAEIGATTS+FPFN M +YL
Sbjct: 245 LKVAGILTVKGGTGAIVEYFGPGVESLSCTGMGTICNMGAEIGATTSIFPFNPRMSEYLR 304
Query: 313 ATGRDKIAQFAQLYHKDLLSADEGAEYDEIIEIDLNTLEPYVNGPFTPDLATPISKMKDV 372
AT R IA +A+ + +++ADE A YD+IIEIDLNTLEP++NGPFTPDLATPISK K+
Sbjct: 305 ATNRSAIADYAEEF-APIIAADENAHYDQIIEIDLNTLEPHLNGPFTPDLATPISKFKEA 363
Query: 373 AVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAATHGLKSKSIFTVTPGSEQIRATI 432
KN+WP E+KVGLIGSCTNSSYEDMSRAAS+ + A G+K+KS+FT+TPGSEQ+RAT+
Sbjct: 364 VKKNDWPQELKVGLIGSCTNSSYEDMSRAASICQQAIDKGIKTKSLFTITPGSEQVRATL 423
Query: 433 ARDGQLETFKEFGGTVLANACGPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTH 492
RDGQL+T ++ GG VLANACGPCIGQW R D+KKG+KN+IV+S+NRNFT RND NP TH
Sbjct: 424 TRDGQLDTMRKAGGIVLANACGPCIGQWKRTDVKKGEKNSIVTSYNRNFTGRNDANPATH 483
Query: 493 SFVASPEITTAFAIAGDLRFNPLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQAP 552
+FV SP+I TA +GD+ FNPLTDTLKDKDGN+F +PPTG GLP KGYDPG NTY AP
Sbjct: 484 AFVTSPDIVTAMVFSGDMNFNPLTDTLKDKDGNDFKFEPPTGAGLPSKGYDPGSNTYVAP 543
Query: 553 PKDRSSVTVQ---VSPTSDRLQLLKPFKAWDGKDAFDMPILIKSLGKTTTDHISMAGPWL 609
SSV V+ + P S RLQ L PFK WDGKD + ILIK+ GK TTDHIS AGPWL
Sbjct: 544 ----SSVNVKDVAIDPHSKRLQRLTPFKKWDGKDMKGLKILIKAKGKCTTDHISAAGPWL 599
Query: 610 KYRGHLENISNNYMIGAINAENKKANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGEN 669
KYRGHL+NISNNYMIGAINAEN +AN +K TGEY VP+ A YRD GIRWV +G +N
Sbjct: 600 KYRGHLQNISNNYMIGAINAENGEANKLKDQLTGEYKTVPNVAIDYRDHGIRWVTLGEQN 659
Query: 670 FGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKINPDDTI 729
FGEGSSREHAALEPR+LGG A+ITKSFARIHETNLKKQG+LPL FA+PAAYDKI+P DT+
Sbjct: 660 FGEGSSREHAALEPRYLGGAAVITKSFARIHETNLKKQGLLPLTFADPAAYDKISPFDTV 719
Query: 730 DILGLTTLAPGKNLIMRVHPKEGEA-WETPLSHTFNAEQIEWFKAGS 775
DI GLTT APGK L + VHP +G A W T L+HTFN +QIEWFKAGS
Sbjct: 720 DIDGLTTFAPGKPLTLVVHPADGSAEWSTKLNHTFNKDQIEWFKAGS 766
>CE25005 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 777
Score = 1001 bits (2587), Expect = 0.0
Identities = 495/742 (66%), Positives = 582/742 (77%), Gaps = 4/742 (0%)
Query: 34 SKVHQNLLEDHSFINYKQNIEYVNIVRERLGRPLTYAEKILYGHLDDPHGQEIERGVSYL 93
SKV + E S++ Y++ + V IV++RL RPLT +EKILYGHLD P Q+IERGVSYL
Sbjct: 27 SKVAISKFEPKSYLPYEKLSQTVKIVKDRLKRPLTLSEKILYGHLDQPKTQDIERGVSYL 86
Query: 94 KLRPDRVACQDATAQMAILQFMSAGLPQVAKPLTVHCDHLIQAQIGGEKDLKRAIDINKE 153
+LRPDRVA QDATAQMA+LQF+S+GLP+ A P T+HCDHLI+AQ GG +DL RA D+NKE
Sbjct: 87 RLRPDRVAMQDATAQMAMLQFISSGLPKTAVPSTIHCDHLIEAQKGGAQDLARAKDLNKE 146
Query: 154 VYDFLATATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNXXXXXXXXXXXX 213
V++FLATA +KY +GFWKPGSGIIHQI+LENYAFPG L+IGTDSHTPN
Sbjct: 147 VFNFLATAGSKYGVGFWKPGSGIIHQIILENYAFPGLLLIGTDSHTPNGGGLGGLCIGVG 206
Query: 214 XXDAVDVMSDLAWELKAPKIMGVKLTGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFG 273
DAVDVM+D+ WELK PK++G+KLTG++NGWTS KD+ILK+A EYFG
Sbjct: 207 GADAVDVMADIPWELKCPKVIGIKLTGKLNGWTSAKDVILKVADILTVKGGTGAIVEYFG 266
Query: 274 DGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIDYLDATGRDKIAQFAQLYHKDLLSA 333
GVD+ SATGMGTICNMGAEIGATTSVFP+N+SM YL+ATGR +IA+ A+ Y KDLL+A
Sbjct: 267 PGVDSISATGMGTICNMGAEIGATTSVFPYNESMYKYLEATGRKEIAEEARKY-KDLLTA 325
Query: 334 DEGAEYDEIIEIDLNTLEPYVNGPFTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNS 393
D+GA YD+IIEI+L+TL P+VNGPFTPDLA+ I K+ + A KN WPL+VKV LIGSCTNS
Sbjct: 326 DDGANYDQIIEINLDTLTPHVNGPFTPDLASSIDKLGENAKKNGWPLDVKVSLIGSCTNS 385
Query: 394 SYEDMSRAASVVKDAATHGLKSKSIFTVTPGSEQIRATIARDGQLETFKEFGGTVLANAC 453
SYEDM+RAAS+ K A GLK+K+IFT+TPGSEQ+RATI RDG + F +FGG VLANAC
Sbjct: 386 SYEDMTRAASIAKQALDKGLKAKTIFTITPGSEQVRATIERDGLSKIFADFGGMVLANAC 445
Query: 454 GPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFN 513
GPCIGQWDRQD+KKG+KNTIV+S+NRNFT RND NP TH FV SP+ITTA AI+G L FN
Sbjct: 446 GPCIGQWDRQDVKKGEKNTIVTSYNRNFTGRNDANPATHGFVTSPDITTAMAISGRLDFN 505
Query: 514 PLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQAPPKDRSSVTVQVSPTSDRLQLL 573
PLTD L DG++F L+ PTG+ LP KGYDPGE+T+QAP S V VSP+SDRLQLL
Sbjct: 506 PLTDELTAADGSKFKLQAPTGLDLPPKGYDPGEDTFQAP---SGSGQVDVSPSSDRLQLL 562
Query: 574 KPFKAWDGKDAFDMPILIKSLGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKK 633
PF WDGKD DM ILIK GK TTDHIS AGPWLKYRGHL+NISNN + AINA+N +
Sbjct: 563 SPFDKWDGKDLEDMKILIKVTGKCTTDHISAAGPWLKYRGHLDNISNNLFLTAINADNGE 622
Query: 634 ANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGGFAIIT 693
N VK+ TGEY VP TAR Y+ G+RWV IG EN+GEGSSREHAALEPR LGG AII
Sbjct: 623 MNKVKNQVTGEYGAVPATARKYKADGVRWVAIGDENYGEGSSREHAALEPRHLGGRAIIV 682
Query: 694 KSFARIHETNLKKQGMLPLNFAEPAAYDKINPDDTIDILGLTTLAPGKNLIMRVHPKEGE 753
KSFARIHETNLKKQGMLPL FA PA YDKI+P D + I+GL++ APGK L G
Sbjct: 683 KSFARIHETNLKKQGMLPLTFANPADYDKIDPSDNVSIVGLSSFAPGKPLTAIFKKTNGS 742
Query: 754 AWETPLSHTFNAEQIEWFKAGS 775
E L+HTFN +QIEWFKAGS
Sbjct: 743 KVEVTLNHTFNEQQIEWFKAGS 764
>Hs4501867 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 780
Score = 967 bits (2500), Expect = 0.0
Identities = 479/750 (63%), Positives = 570/750 (75%), Gaps = 1/750 (0%)
Query: 26 VSSTMTRDSKVHQNLLEDHSFINYKQNIEYVNIVRERLGRPLTYAEKILYGHLDDPHGQE 85
V+S + + +KV + E + +I+Y + +NIVR+RL RPLT +EKI+YGHLDDP QE
Sbjct: 22 VASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPASQE 81
Query: 86 IERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPLTVHCDHLIQAQIGGEKDLK 145
IERG SYL+LRPDRVA QDATAQMA+LQF+S+GL +VA P T+HCDHLI+AQ+GGEKDL+
Sbjct: 82 IERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLR 141
Query: 146 RAIDINKEVYDFLATATAKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNXXXX 205
RA DIN+EVY+FLATA AKY +GFWKPGSGIIHQI+LENYA+PG L+IGTDSHTPN
Sbjct: 142 RAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGL 201
Query: 206 XXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRMNGWTSPKDIILKLAXXXXXXXXX 265
DAVDVM+ + WELK PK++GVKLTG ++GW+SPKD+ILK+A
Sbjct: 202 GGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGT 261
Query: 266 XXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIDYLDATGRDKIAQFAQL 325
EY G GVD+ S TGM TICNMGAEIGATTSVFP+N M YL TGR+ IA A
Sbjct: 262 GAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADE 321
Query: 326 YHKDLLSADEGAEYDEIIEIDLNTLEPYVNGPFTPDLATPISKMKDVAVKNNWPLEVKVG 385
+ KD L D G YD++IEI+L+ L+P++NGPFTPDLA P++++ VA K WPL+++VG
Sbjct: 322 F-KDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVG 380
Query: 386 LIGSCTNSSYEDMSRAASVVKDAATHGLKSKSIFTVTPGSEQIRATIARDGQLETFKEFG 445
LIGSCTNSSYEDM R+A+V K A HGLK KS FT+TPGSEQIRATI RDG + ++ G
Sbjct: 381 LIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLG 440
Query: 446 GTVLANACGPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFA 505
G VLANACGPCIGQWDR+DIKKG+KNTIV+S+NRNFT RND NP+TH+FV SPEI TA A
Sbjct: 441 GIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALA 500
Query: 506 IAGDLRFNPLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQAPPKDRSSVTVQVSP 565
IAG L+FNP TD L DG +F L+ P LP +DPG++TYQ PPKD S V VSP
Sbjct: 501 IAGTLKFNPETDYLTGTDGKKFRLEAPDADELPKGEFDPGQDTYQHPPKDSSGQHVDVSP 560
Query: 566 TSDRLQLLKPFKAWDGKDAFDMPILIKSLGKTTTDHISMAGPWLKYRGHLENISNNYMIG 625
TS RLQLL+PF WDGKD D+ ILIK GK TTDHIS AGPWLK+RGHL+NISNN +IG
Sbjct: 561 TSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIG 620
Query: 626 AINAENKKANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRF 685
AIN EN KAN V++ T E+ VPDTAR Y+ GIRWVVIG EN+GEGSSREHAALEPR
Sbjct: 621 AINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRH 680
Query: 686 LGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKINPDDTIDILGLTTLAPGKNLIM 745
LGG AIITKSFARIHETNLKKQG+LPL FA+PA Y+KI+P D + I GL PGK L
Sbjct: 681 LGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHPVDKLTIQGLKDFTPGKPLKC 740
Query: 746 RVHPKEGEAWETPLSHTFNAEQIEWFKAGS 775
+ G L+HTFN QIEWF+AGS
Sbjct: 741 IIKHPNGTQETILLNHTFNETQIEWFRAGS 770
>7299398 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 769
Score = 930 bits (2403), Expect = 0.0
Identities = 461/727 (63%), Positives = 543/727 (74%), Gaps = 2/727 (0%)
Query: 49 YKQNIEYVNIVRERLGRPLTYAEKILYGHLDDPHGQEIERGVSYLKLRPDRVACQDATAQ 108
YK+ E ++ ++ RLG PLT +EK+LY HLD P QEIERG SYL+LRPDRVA QDATAQ
Sbjct: 29 YKKLRENLDCIKGRLGGPLTLSEKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQ 88
Query: 109 MAILQFMSAGLPQVAKPLTVHCDHLIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNMG 168
M +LQF+S+GL +VA P TVHCDHLI+AQI G+KDL RA D+NKEVYDFL++A AKYN+G
Sbjct: 89 MTLLQFISSGLKKVAVPSTVHCDHLIEAQISGDKDLARAKDLNKEVYDFLSSACAKYNLG 148
Query: 169 FWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWEL 228
FWKPGSGIIHQI+LENYAFPG L+IGTDSHTPN DAVDVM+++ WEL
Sbjct: 149 FWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGCLCVGVGGADAVDVMANIPWEL 208
Query: 229 KAPKIMGVKLTGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTIC 288
K P ++G LTG+++GWTSPKD+ILK+A EY G GV++ S TGM TI
Sbjct: 209 KCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVESISCTGMATIT 268
Query: 289 NMGAEIGATTSVFPFNKSMIDYLDATGRDKIAQFAQLYHKDLLSADEGAEYDEIIEIDLN 348
NMGAEIGATTS+FPFN+ M+ YL ATGR IA A +KDLL DEG +YD++IEI+L+
Sbjct: 269 NMGAEIGATTSIFPFNERMVTYLRATGRGAIADEATK-NKDLLVPDEGCKYDKVIEINLD 327
Query: 349 TLEPYVNGPFTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDA 408
TLEP VNGPFTPDLA PISK+ + KN +P+E+KV LIGSCTNSSYEDM R AS+ DA
Sbjct: 328 TLEPLVNGPFTPDLAHPISKLGQNSEKNGYPMEIKVSLIGSCTNSSYEDMGRCASIANDA 387
Query: 409 ATHGLKSKSIFTVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCIGQWDRQDIKKG 468
HGLKS F VTPGSEQ+RATIARDG ++ ++FGGTVLANACGPCIGQWDR+D+K G
Sbjct: 388 LGHGLKSCVPFNVTPGSEQVRATIARDGIIDVLEKFGGTVLANACGPCIGQWDRKDVKMG 447
Query: 469 DKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFNPLTDTLKDKDGNEFM 528
+KNTIV+S+NRNFT RND NP TH FV SPE+ TA AIAG L FNP+TD L DG F
Sbjct: 448 EKNTIVTSYNRNFTGRNDANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTDGKTFK 507
Query: 529 LKPPTGVGLPVKGYDPGENTYQAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDGKDAFDMP 588
LK P G LP KG+DPGE+TYQAPP + V V P SDRLQLL+PF+ WDGKD D+
Sbjct: 508 LKEPHGEELPSKGFDPGEDTYQAPPAKADDIKVNVDPKSDRLQLLEPFEKWDGKDYIDLM 567
Query: 589 ILIKSLGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKHHYTGEYAGV 648
+LIK GK TTDHIS AGPWLKYRGHL+NISNN IGA NAEN + N VK+ TG + V
Sbjct: 568 VLIKIKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNAENNEMNKVKNQKTGSFDAV 627
Query: 649 PDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQG 708
P AR Y+ I+W +G EN+GEGSSREHAALEPR LGG AII KSFARIHETNLKKQG
Sbjct: 628 PAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRHLGGVAIIVKSFARIHETNLKKQG 687
Query: 709 MLPLNFAEPAAYDKINPDDTIDILGLTTLAPGKNLIMRVHPKEGEAWETPLSHTFNAEQI 768
ML L FA P YDK+ P I IL L LAPGK + + G + + L+HT N QI
Sbjct: 688 MLALTFANPGDYDKVQPSSKISILNLKDLAPGKPVDAEI-KNNGSSDKIQLNHTLNELQI 746
Query: 769 EWFKAGS 775
+WF+AGS
Sbjct: 747 QWFQAGS 753
>7298762 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 683
Score = 891 bits (2303), Expect = 0.0
Identities = 440/674 (65%), Positives = 512/674 (75%), Gaps = 3/674 (0%)
Query: 103 QDATAQMAILQFMSAGLPQVAKPLTVHCDHLIQAQIGGEKDLKRAIDINKEVYDFLATAT 162
QDATAQMA+LQF+S+GL +VA P TVHCDHLI+AQIGG KDL RA D+NKEVYDFLA+
Sbjct: 2 QDATAQMALLQFISSGLKKVAVPSTVHCDHLIEAQIGGPKDLARAKDLNKEVYDFLASTC 61
Query: 163 AKYNMGFWKPGSGIIHQIVLENYAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMS 222
AKY +GFWKPGSGIIHQI+LENYAFPG L+IGTDSHTPN DAVDVM+
Sbjct: 62 AKYGLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMA 121
Query: 223 DLAWELKAPKIMGVKLTGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSAT 282
D+ WELK PK++GV LTG+++GWTSPKD+ILK+A EY G GVD+ S T
Sbjct: 122 DIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGTGAIIEYHGKGVDSISCT 181
Query: 283 GMGTICNMGAEIGATTSVFPFNKSMIDYLDATGRDKIAQFAQLYHKDLLSADEGAEYDEI 342
GM TICNMGAEIGATTS+FPFN+ M DYL +TGR IA AQ Y +LSAD+ EYDE+
Sbjct: 182 GMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQKYQAKILSADKNCEYDEL 241
Query: 343 IEIDLNTLEPYVNGPFTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAA 402
IEI+L+TLEP+VNGPFTPDL PISK+ + + KN +P++++VGLIGSCTNSSYEDM R A
Sbjct: 242 IEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSCTNSSYEDMGRCA 301
Query: 403 SVVKDAATHGLKSKSIFTVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCIGQWDR 462
S+ KDA +HGLKSK F VTPGSEQIRATI RDG E F +FGGTVLANACGPCIGQWDR
Sbjct: 302 SIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDR 361
Query: 463 QDIKKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFNPLTDTLKDK 522
+D+KKGDKNTIV+S+NRNFT RND NP TH FV SPE+ TA +IAG L FNPLTD L
Sbjct: 362 KDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGA 421
Query: 523 DGNEFMLKPPTGVGLPVKGYDPGENTYQAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDGK 582
DG +F LK P G LP KG+DPG++TY APP +V V V P S RLQLL+PF W+G+
Sbjct: 422 DGKKFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQ 481
Query: 583 DAFDMPILIKSLGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKHHYT 642
D D+ +LIK GK TTDHIS AGPWLKYRGHL+NISNN IGA N EN + N +K+
Sbjct: 482 DLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRN 541
Query: 643 GEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGGFAIITKSFARIHET 702
G + GVPD AR Y+ GI+WV +G EN+GEGSSREHAALEPR LGG AII KSFARIHET
Sbjct: 542 GSWGGVPDVARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHET 601
Query: 703 NLKKQGMLPLNFAEPAAYDKINPDDTIDILGLTTLAPGKNLIMRVHPKEGEAWE-TPLSH 761
NLKKQG+LPL FA PA YDKI P I +L L +LAPGK + + K G+ E L+H
Sbjct: 602 NLKKQGLLPLTFANPADYDKIQPTSKISLLNLKSLAPGKPVDAEI--KNGDKVERIKLNH 659
Query: 762 TFNAEQIEWFKAGS 775
T N QI WFKAGS
Sbjct: 660 TLNDLQIGWFKAGS 673
>YJL200c [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 789
Score = 752 bits (1942), Expect = 0.0
Identities = 384/727 (52%), Positives = 495/727 (67%), Gaps = 19/727 (2%)
Query: 66 PLTYAEKILYGHLDDPHGQEIE------RGVSYLKLRPDRVACQDATAQMAILQFMSAGL 119
PLT AEKILY HL DP RG YLKL PDRVA QDA+AQMA+LQFM+ GL
Sbjct: 53 PLTLAEKILYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGL 112
Query: 120 PQVAKPLTVHCDHLIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNMGFWKPGSGIIHQ 179
Q + P ++HCDHLI + G KDL +I N+EV+DFL + +Y + FW PGSGIIHQ
Sbjct: 113 NQTSVPASIHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGIQFWGPGSGIIHQ 172
Query: 180 IVLENYAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLT 239
IVLEN++ PG +++GTDSHTPN DAVD ++ WELKAPKI+GVKLT
Sbjct: 173 IVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLT 232
Query: 240 GRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTS 299
G++NGW++PKD+I KLA EYFG+GV T S TGM TICNMGAEIGATTS
Sbjct: 233 GKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTS 292
Query: 300 VFPFNKSMIDYLDATGRDKIAQFAQ--LYHKDLLSADEGAEYDEIIEIDLNTLEPYVNGP 357
FP+ ++ YL AT R ++A+ A L + L AD+ A+YD++IEIDL+ +EP+VNGP
Sbjct: 293 TFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGP 352
Query: 358 FTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAATHGLKSKS 417
FTPDL+TPIS+ + ++K NWP +V GLIGSCTNSSY+DMSR +VK A+ GLK +
Sbjct: 353 FTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVKQASKAGLKPRI 412
Query: 418 IFTVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCIGQWDRQDIKKGDK--NTIVS 475
F VTPGSEQIRAT+ RDG ++ F+E G VLANACGPCIGQW+R+D+ K K NTI +
Sbjct: 413 PFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKETNTIFT 472
Query: 476 SFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFNPLTDTLKDKDGNEFMLKPPTGV 535
SFNRNF ARNDGN +T +F+ SPEI TA + +GD +FNPLTD++K +G +F +PP G
Sbjct: 473 SFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKGD 532
Query: 536 GLPVKGYDPGENTY--QAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDGKDAFDMPILIKS 593
LP +G++ G + + + PK S+V ++V P SDRLQLL+PFK W+GK+ +L+K
Sbjct: 533 ELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKE-LKTNVLLKV 591
Query: 594 LGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKHHYTGEYAGVPDTAR 653
GK TTDHIS AG WLKY+GHLENIS N +IGA N E + N + G +P
Sbjct: 592 EGKCTTDHISAAGVWLKYKGHLENISYNTLIGAQNKETGEVN-KAYDLDGTEYDIPGLMM 650
Query: 654 AYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGMLPLN 713
++ G W VI N+GEGS+REHAAL PRFLGG ++ KSFARIHETNLKKQG+LPL
Sbjct: 651 KWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLT 710
Query: 714 FAEPAAYDKINPDDTIDILGLTTLAP-----GKNLIMRVHPKEGEAWETPLSHTFNAEQI 768
FA + YDKI+ D ++ L L + G + +++ GE++ HT + +QI
Sbjct: 711 FANESDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQI 770
Query: 769 EWFKAGS 775
++FKAGS
Sbjct: 771 DFFKAGS 777
>SPBP4H10.15 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 905
Score = 719 bits (1857), Expect = 0.0
Identities = 370/726 (50%), Positives = 476/726 (64%), Gaps = 16/726 (2%)
Query: 64 GRPLTYAEKILYGHLDDPH------GQEIERGVSYLKLRPDRVACQDATAQMAILQFMSA 117
G+ LT AEK+LY HL +P RG YLKL PDRVA QDA+AQMA+LQFM+
Sbjct: 54 GQKLTLAEKVLYSHLVNPEESFSGVSPSDIRGSLYLKLNPDRVAMQDASAQMALLQFMTC 113
Query: 118 GLPQVAKPLTVHCDHLIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNMGFWKPGSGII 177
GL + P ++HCDHLI G D+ +I NKE++DFL +A KY + FW PGSGII
Sbjct: 114 GLEKTMIPASIHCDHLIVGHRGANSDIPDSIANNKEIFDFLQSAAKKYGIQFWGPGSGII 173
Query: 178 HQIVLENYAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVK 237
HQIVLENYA PG +++GTDSHTPN DAVD M++ WELKAPKI+GV
Sbjct: 174 HQIVLENYAAPGGMMLGTDSHTPNAGGLGMIAIGVGGADAVDAMTNTPWELKAPKIIGVN 233
Query: 238 LTGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGAT 297
LTG M+GWT+PKD+IL LA EYFG GV + S TGM T+CNMGAE+GAT
Sbjct: 234 LTGAMSGWTTPKDLILHLAGKLTVRGGTGHIIEYFGPGVASLSCTGMATVCNMGAEVGAT 293
Query: 298 TSVFPFNKSMIDYLDATGRDKIAQFAQLYHKD--LLSADEGAEYDEIIEIDLNTLEPYVN 355
TS+FP+ SM YL AT R ++A A H + L+AD GA+YD+II+I+L+ L P +N
Sbjct: 294 TSIFPYTDSMRRYLIATHRAEVADAASEVHSEYNYLAADTGAKYDQIIDINLSELTPSLN 353
Query: 356 GPFTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAATHGLKS 415
GPFTPDL+TP+SK + KN WP ++ GLIGSCTNSSY+DM+ VV+ A + GLK
Sbjct: 354 GPFTPDLSTPVSKFGEAIEKNKWPKKLSAGLIGSCTNSSYQDMTCVVDVVEQAISAGLKP 413
Query: 416 KSIFTVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCIGQWDR-QDIKKGDKNTIV 474
K F VTPGSEQIRATI RDG E +E G TVLANACGPCIG W R DI G+ N I+
Sbjct: 414 KVPFLVTPGSEQIRATIERDGITERLEEAGATVLANACGPCIGMWKRTDDIASGEPNAIL 473
Query: 475 SSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFNPLTDTLKDKDGNEFMLKPPTG 534
+SFNRNF +RNDGNP T +F+ SP I A + DL F+P DTL+ DG F +PP G
Sbjct: 474 TSFNRNFRSRNDGNPSTMNFLTSPVIVAAKIFSSDLAFDPTHDTLQTPDGKAFKFRPPQG 533
Query: 535 VGLPVKGYDPGENTY--QAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDGKDAFDMPILIK 592
V LP G+ G+++Y + P+ V + P SDRL+ L+PF+ + G + ++ + +K
Sbjct: 534 VELPSAGFIAGDSSYIPEPNPQPVPETEVTIDPKSDRLEALEPFEPYQGGEMENLKVAVK 593
Query: 593 SLGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKHHYTGEYAGVPDTA 652
GK TTDHIS AG WLKY+GHL NI NN +IGA+NA + N + + G+ +P+
Sbjct: 594 VKGKCTTDHISAAGKWLKYKGHLSNICNNTLIGAMNAATGEVN--RAYDNGKGMTIPELM 651
Query: 653 RAYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGMLPL 712
++ G W+V+ N+GEGS+REHAAL+PR + G I+TKSFARIHETNLKKQG+LPL
Sbjct: 652 WKWKKDGQPWLVVAEHNYGEGSAREHAALQPRAMNGRIILTKSFARIHETNLKKQGVLPL 711
Query: 713 NFAEPAAYDKINPDDTIDILGLTTLAPG---KNLIMRVHPKEGEAWETPLSHTFNAEQIE 769
F A Y+KI+ +D + G+ L G + + + V K+G E P HT + +QIE
Sbjct: 712 TFVNEADYEKIDAEDKVSTRGIEQLLEGVLDQPITLVVTKKDGSVVEIPCKHTMSKDQIE 771
Query: 770 WFKAGS 775
+FKAGS
Sbjct: 772 FFKAGS 777
>Hs17489116 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 716
Score = 470 bits (1210), Expect = e-132
Identities = 252/464 (54%), Positives = 304/464 (65%), Gaps = 23/464 (4%)
Query: 315 GRDKIAQFAQLYHKDLLSADEGAEYDEIIEIDLNTLEPYVNGPFTPDLATPISKMKDVAV 374
GR IA A + +D L D G YD++IEI+L+ L+P++NGPFTPD A P++++ VA
Sbjct: 263 GRTDIANLADEF-QDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDQAHPVAEVGKVAE 321
Query: 375 KNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAATHGLKSKSIFTVTPGSEQIRATIAR 434
K WPL+++VGL +V K A H K KS FT+TPGSEQI ATI R
Sbjct: 322 KEGWPLDIRVGL---------------TAVAKQALAHDFKCKSHFTITPGSEQIHATIER 366
Query: 435 DGQLETFKEFGGTVLANACGPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTHSF 494
D + + GG VLANACGPCIG+WD +DIKKG K TIV+S+NRNFT ND NP+TH F
Sbjct: 367 DSYAQILRNVGGIVLANACGPCIGRWDTKDIKKGKKYTIVTSYNRNFTGCNDANPETHVF 426
Query: 495 VASPEITTAFAIAGDLRFNPLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQAPPK 554
V SPEI TA AI G L+FNP T+ L KD +F L+ LP + +DPG++ YQ PP+
Sbjct: 427 VTSPEIVTALAIVGILKFNPETNYLMGKDRKKFKLEALDADDLPQEEFDPGQDPYQHPPQ 486
Query: 555 DRSSVTVQVSPTSDRLQLLKPFKAWDGKDAFDMPILIKSLGKTTTDHISMAGPWLKYRGH 614
D S V VSPTS RLQLL+ F WD KD D ILIK GK TTDHIS AGPWLK+ GH
Sbjct: 487 DSSGQHVDVSPTSQRLQLLEAFDKWDSKDLEDPQILIKVKGKCTTDHISAAGPWLKFCGH 546
Query: 615 LENISNNYMIGAINAENKKANCV---KHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFG 671
L+NISNN + GAIN EN +AN V T E+ VPDTAR Y+ GIRWVVIG EN
Sbjct: 547 LDNISNNLLTGAINIENSQANSVCSANIENTQEFGPVPDTARYYKKHGIRWVVIGDEN-- 604
Query: 672 EGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKINPDDTIDI 731
SSREHA LEP L G AIITKSFARIH+TN KKQG+LPL FA+P Y+K++P D + I
Sbjct: 605 --SSREHAVLEPPHLWGQAIITKSFARIHKTNPKKQGLLPLTFADPGDYNKVHPVDKLTI 662
Query: 732 LGLTTLAPGKNLIMRVHPKEGEAWETPLSHTFNAEQIEWFKAGS 775
GL AP K L + G L+HTFN +I+WF AGS
Sbjct: 663 QGLKDFAPDKPLKCIIKHPNGTQETILLNHTFNEMRIKWFCAGS 706
Score = 58.5 bits (140), Expect = 4e-08
Identities = 29/64 (45%), Positives = 43/64 (66%)
Query: 26 VSSTMTRDSKVHQNLLEDHSFINYKQNIEYVNIVRERLGRPLTYAEKILYGHLDDPHGQE 85
V+S + + +K+ + E + +I+Y + +NIV +RL PLT EKI+YGHLDDP QE
Sbjct: 160 VASVLCQRAKMAMSHFEPNEYIHYDLLEKNINIVCKRLNWPLTLLEKIVYGHLDDPASQE 219
Query: 86 IERG 89
IE+G
Sbjct: 220 IEQG 223
>Hs22051976 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 293
Score = 274 bits (700), Expect = 4e-73
Identities = 144/249 (57%), Positives = 166/249 (65%)
Query: 454 GPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFN 513
GP IGQWDR++IKKG+KNTIV+S+NRNFT RND NP T + SPEI TA AIA L
Sbjct: 39 GPRIGQWDRKNIKKGEKNTIVTSYNRNFTGRNDTNPKTMPSIISPEIVTALAIARTLSST 98
Query: 514 PLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQAPPKDRSSVTVQVSPTSDRLQLL 573
L + + T LP +DPG++TYQ PPKD S V VS TS LQL+
Sbjct: 99 QRPTALWARMARSSSWRLQTQYELPQAQFDPGQDTYQHPPKDSSRQHVDVSSTSQHLQLV 158
Query: 574 KPFKAWDGKDAFDMPILIKSLGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKK 633
+PF WDGKD D+ ILIK GK TDHIS AGPWLK+ GHLE ISNN +IGA+N EN K
Sbjct: 159 EPFDKWDGKDLEDLQILIKVKGKCPTDHISAAGPWLKFHGHLEYISNNLLIGAMNIENSK 218
Query: 634 ANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGGFAIIT 693
AN V + T E+ +PDTAR Y+ GIRWVVI EN+ E S EH ALE L G AIIT
Sbjct: 219 ANSVHNALTQEFGPIPDTARYYKKHGIRWVVIRDENYREDSHGEHTALEHHLLRGRAIIT 278
Query: 694 KSFARIHET 702
KSFARIHET
Sbjct: 279 KSFARIHET 287
>Hs22068703 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 517
Score = 263 bits (671), Expect = 1e-69
Identities = 143/336 (42%), Positives = 189/336 (55%), Gaps = 57/336 (16%)
Query: 217 AVDVMSDLAWELKAPKIMGVKLTGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGV 276
AVDVM+ + WELK PK++GVKL G ++GWTSPKD+ILK+A EY G V
Sbjct: 167 AVDVMTGIPWELKCPKVIGVKLMGSLSGWTSPKDVILKVAGILTMKGGTGAIVEYHGPVV 226
Query: 277 DTFSATGMGTICNMGAEIGATTSVFPFNKSMIDYLDATGRDKIAQFAQLYHKDLLSADEG 336
D+ S TGM T+CNMG EIG TTSVF +N M Y+ T + IA A + KD L D G
Sbjct: 227 DSISCTGMVTVCNMGLEIGTTTSVFHYNLRMKKYMSKTCQADIANLADEF-KDHLVPDPG 285
Query: 337 AEYDEIIEIDLNTLEPYVNGPFTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYE 396
YD++IE++ + L+ ++NGPFTPDLA P++++ +
Sbjct: 286 CHYDQLIEVNPSELKLHINGPFTPDLAHPVAEVGKI------------------------ 321
Query: 397 DMSRAASVVKDAATHGLKSKSIFTVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPC 456
AS+ +D G +T ++ GG VLANACGPC
Sbjct: 322 ----RASIEQD----------------------------GYAQTLRDVGGIVLANACGPC 349
Query: 457 IGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFNPLT 516
IGQ R+DI K +KN IV+S+NRNF ND NP+TH+F+ SPE TA AI G L+FNP T
Sbjct: 350 IGQLHRKDINKQEKNIIVTSYNRNFMGHNDTNPETHAFITSPETVTALAIVGTLKFNPET 409
Query: 517 DTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQAP 552
+ L KDG +F L+ P LP + PG++TYQ P
Sbjct: 410 NYLTGKDGKKFKLEAPDADELPQAEFGPGQDTYQHP 445
>Hs8659555 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 889
Score = 192 bits (488), Expect = 2e-48
Identities = 211/769 (27%), Positives = 319/769 (41%), Gaps = 146/769 (18%)
Query: 96 RPDRVACQDATAQMAILQFMS--------AGLPQVAKPLT---VHCDHLIQAQIGGEKD- 143
+P RV QD T A++ F + G P+ P+ + DH IQ D
Sbjct: 79 KPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADS 138
Query: 144 LKRAIDI----NKEVYDFLATAT-AKYNMGFWKPGSGIIHQIVLE----------NYAFP 188
L++ D+ N+E ++FL + A +NM PGSGIIHQ+ LE Y +P
Sbjct: 139 LQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYP 198
Query: 189 GALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRMNGWTSP 248
+L+ GTDSHT +A VM + P+++G +L G+ + +
Sbjct: 199 DSLV-GTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTS 257
Query: 249 KDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMI 308
DI+L + E+FG GV S TI NM E GAT + FP ++ I
Sbjct: 258 TDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSI 317
Query: 309 DYLDATGRDK-----IAQFAQL--YHKDLLSADEGAEYDEIIEIDLNTLEPYVNGPFTPD 361
YL TGRD+ I ++ Q +D + ++ +++E+DL T+ P +GP P
Sbjct: 318 TYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQ 377
Query: 362 LATPISKMK--------------------------DVAVKNNWPL-----EVKVGLIGSC 390
+S MK + +N V + I SC
Sbjct: 378 DKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSC 437
Query: 391 TNSSYED-MSRAASVVKDAATHGLKSKSIF--TVTPGSEQIRATIARDGQLETFKEFGGT 447
TN+S M A + K A GL +++PGS + + G + + G
Sbjct: 438 TNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFD 497
Query: 448 VLANACGPCIGQWDR------QDIKKGDKNTI-VSSFNRNFTARNDGNPDTH-SFVASPE 499
V+ C CIG + I +GD + V S NRNF R +P+T +++ASP
Sbjct: 498 VVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGR--VHPNTRANYLASPP 555
Query: 500 ITTAFAIAGDLRFNPLTDTL-KDKDGNEFMLKPPTGVGLPVKGYD-----PG--ENTYQ- 550
+ A+AIAG +R + + L + G + LK ++ + PG + YQ
Sbjct: 556 LVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQK 615
Query: 551 -----------APPKDR------SSVTVQVSPTSDRLQL-LKPFKAWDGKDAFDMPILIK 592
A P D+ S ++ P + L L L+P K D +L+
Sbjct: 616 IETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQP-----PKSIVDAYVLLN 670
Query: 593 SLGKTTTDHISMAG---------PWLKYRGHLENISNNY----------------MIGAI 627
TTDHIS AG +L RG N+Y I +
Sbjct: 671 LGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLL 730
Query: 628 NA-ENKKANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRFL 686
N NK+A H +GE V D A Y+ AG+ +V+ G+ +G GSSR+ AA P L
Sbjct: 731 NRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLL 790
Query: 687 GGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKINPDDTIDILGLT 735
G A++ +S+ RIH +NL G++PL + P + D LGLT
Sbjct: 791 GIKAVLAESYERIHRSNLVGMGVIPLEYL---------PGENADALGLT 830
>At4g35830 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 898
Score = 179 bits (455), Expect = 1e-44
Identities = 201/762 (26%), Positives = 300/762 (38%), Gaps = 158/762 (20%)
Query: 93 LKLRPDRVACQDATAQMAILQFM-----------SAGLPQVAKPLTVHCDHLIQAQIGGE 141
+ +P RV QD T A++ + P+ + DH +Q +
Sbjct: 80 IPFKPARVLLQDFTGVPAVVDLACMRDAMNNLGGDSNKINPLVPVDLVIDHSVQVDVARS 139
Query: 142 KDLKRA-----IDINKEVYDFLATAT-AKYNMGFWKPGSGIIHQIVLENYA--------- 186
++ +A NKE + FL + A +NM PGSGI+HQ+ LE A
Sbjct: 140 ENAVQANMELEFQRNKERFAFLKWGSNAFHNMLVVPPGSGIVHQVNLEYLARVVFNTNGL 199
Query: 187 -FPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRMNGW 245
+P + ++GTDSHT +A M + P ++G KLTG++
Sbjct: 200 LYPDS-VVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLTGKLRDG 258
Query: 246 TSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNK 305
+ D++L + E+ G+G+ S TI NM E GAT FP +
Sbjct: 259 MTATDLVLTVTQMLRKHGVVGKFVEFHGEGMRELSLADRATIANMSPEYGATMGFFPVDH 318
Query: 306 SMIDYLDATGR-DKIAQFAQLYHK------DLLSADEGAEYDEIIEIDLNTLEPYVNGPF 358
+ YL TGR D + Y + D + Y +E++L +EP V+GP
Sbjct: 319 VTLQYLRLTGRSDDTVSMIEAYLRANKMFVDYSEPESKTVYSSCLELNLEDVEPCVSGPK 378
Query: 359 TPDLATPISKMK-----------------------DVAVKNNW--------PLEVKVGLI 387
P P+ +MK AV+ N+ +V + I
Sbjct: 379 RPHDRVPLKEMKADWHSCLDNRVGFKGFAVPKEAQSKAVEFNFNGTTAQLRHGDVVIAAI 438
Query: 388 GSCTNSSYED-MSRAASVVKDAATHGLKSKSIF--TVTPGSEQIRATIARDGQLETFKEF 444
SCTN+S M AA V K A GL+ K ++ PGS + +A+ G + +
Sbjct: 439 TSCTNTSNPSVMLGAALVAKKACDLGLEVKPWIKTSLAPGSGVVTKYLAKSGLQKYLNQL 498
Query: 445 GGTVLANACGPCIGQWDRQDIKKGDKNTIVS---------SFNRNFTARNDGNPDTH-SF 494
G +++ C CIG + DI + + IV S NRNF R +P T ++
Sbjct: 499 GFSIVGYGCTTCIG--NSGDIHEAVASAIVDNDLVASAVLSGNRNFEGR--VHPLTRANY 554
Query: 495 VASPEITTAFAIAGDLRFNPLTDTL-KDKDGNEFMLKPPTGVGLPVKGY-------DPGE 546
+ASP + A+A+AG + + T + KDG + + V D +
Sbjct: 555 LASPPLVVAYALAGTVDIDFETQPIGTGKDGKQIFFRDIWPSNKEVAEVVQSSVLPDMFK 614
Query: 547 NTYQAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDGKDAF--------------------- 585
TY+A K +S+ Q+S S L WD K +
Sbjct: 615 ATYEAITKG-NSMWNQLSVASGTLY------EWDPKSTYIHEPPYFKGMTMSPPGPHGVK 667
Query: 586 DMPILIKSLGKTTTDHISMAG------PWLKY-------------------------RGH 614
D L+ TTDHIS AG P KY RG
Sbjct: 668 DAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLMERGVDRRDFNSYGSRRGNDEIMARGT 727
Query: 615 LENIS--NNYMIGAINAENKKANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGE 672
NI N ++ G + + H TGE V D A YR+ G +++ G +G
Sbjct: 728 FANIRIVNKHLKGEVGPK------TVHIPTGEKLSVFDAAMKYRNEGRDTIILAGAEYGS 781
Query: 673 GSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGMLPLNF 714
GSSR+ AA P LG A+I+KSF RIH +NL G++PL F
Sbjct: 782 GSSRDWAAKGPMLLGVKAVISKSFERIHRSNLVGMGIIPLCF 823
>At4g26970 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 907
Score = 178 bits (452), Expect = 3e-44
Identities = 205/753 (27%), Positives = 293/753 (38%), Gaps = 140/753 (18%)
Query: 93 LKLRPDRVACQDATAQMAILQFMS--------AGLPQVAKPLT---VHCDHLIQAQIG-- 139
+ +P RV QD T ++ S P PL + DH IQ
Sbjct: 89 IAFKPARVILQDFTGVPVLVDLASMRDAVKNLGSDPSKINPLVPVDLVVDHSIQVDFARS 148
Query: 140 ---GEKDLKRAIDINKEVYDFLAT-ATAKYNMGFWKPGSGIIHQIVLE----------NY 185
+K+L+ NKE + FL +TA NM PGSGI+HQ+ LE +
Sbjct: 149 EDAAQKNLELEFKRNKERFTFLKWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVFNSKGF 208
Query: 186 AFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRMNGW 245
+P + ++GTDSHT +A M + P ++G KL G++
Sbjct: 209 LYPDS-VVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLDGKLKEG 267
Query: 246 TSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNK 305
+ D++L + E++G+G+ S TI NM E GAT FP +
Sbjct: 268 VTATDLVLTVTQILRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDH 327
Query: 306 SMIDYLDATGRDKIA--------QFAQLYHKDLLSADEGAEYDEIIEIDLNTLEPYVNGP 357
++YL TGR + L++ E A Y ++++L +EP ++GP
Sbjct: 328 VTLEYLKLTGRSDETVNPLSLSLSLSLLFYSFFFGKQERA-YTSYLQLELGHVEPCISGP 386
Query: 358 FTPDLATPISKMK-----------------------DVAVK---NNWPLEVKVG-----L 386
P P+ MK + VK N P E+K G
Sbjct: 387 KRPHDRVPLKDMKADWHACLDNPVGFKGFAVPKEKQEEVVKFSYNGQPAEIKHGSVVIAA 446
Query: 387 IGSCTNSSYED-MSRAASVVKDAATHGLKSKSIF--TVTPGSEQIRATIARDGQLETFKE 443
I SCTN+S M AA V K A+ GLK K ++ PGS + + R G E+ +
Sbjct: 447 ITSCTNTSNPSVMIGAALVAKKASDLGLKVKPWVKTSLAPGSRVVEKYLDRSGLRESLTK 506
Query: 444 FGGTVLANACGPCIGQWDRQD--IKKGDKNT-----IVSSFNRNFTARNDGNPDTH-SFV 495
G ++ C CIG D + + T V S NRNF R +P T +++
Sbjct: 507 QGFEIVGYGCTTCIGNSGNLDPEVASAIEGTDIIPAAVLSGNRNFEGR--VHPQTRANYL 564
Query: 496 ASPEITTAFAIAG----DLRFNPLTDTLKDKD--------GNEFMLKPPTGVGLP----- 538
ASP + A+A+AG D P+ K NE + + LP
Sbjct: 565 ASPPLVVAYALAGTVDIDFEKEPIGTRSDGKSVYLRDVWPSNEEVAQVVQYSVLPSMFKS 624
Query: 539 ----VKGYDPGENTYQAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDG-----KDAFDMPI 589
+ +P N AP SS P S + FK ++ D
Sbjct: 625 SYETITEGNPLWNELSAP----SSTLYSWDPNSTYIHEPPYFKNMTANPPGPREVKDAYC 680
Query: 590 LIKSLGKTTTDHISMAG---------PWLKYRGHLENISNNY-------------MIGAI 627
L+ TTDHIS AG +L RG + N+Y I
Sbjct: 681 LLNFGDSVTTDHISPAGNIQKTSPAAKFLMDRGVISEDFNSYGSRRGNDEVMARGTFANI 740
Query: 628 NAENK------KANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAAL 681
NK N V H TGE V D A Y+ A +++ G +G GSSR+ AA
Sbjct: 741 RIVNKLLKGEVGPNTV-HIPTGEKLSVFDAASKYKTAEQDTIILAGAEYGSGSSRDWAAK 799
Query: 682 EPRFLGGFAIITKSFARIHETNLKKQGMLPLNF 714
P LG A+I KSF RIH +NL G++PL F
Sbjct: 800 GPLLLGVKAVIAKSFERIHRSNLAGMGIIPLCF 832
>At2g05710 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 898
Score = 173 bits (438), Expect = 1e-42
Identities = 203/773 (26%), Positives = 306/773 (39%), Gaps = 147/773 (19%)
Query: 93 LKLRPDRVACQDATAQMAILQF--MSAGLPQVAK---------PLTVHCDHLIQAQIGGE 141
+ +P RV QD T A++ M + ++ P+ + DH +Q +
Sbjct: 80 IPFKPARVLLQDFTGVPAVVDLACMRDAMNKLGSDSNKINPLVPVDLVIDHSVQVDVARS 139
Query: 142 KDLKRA-----IDINKEVYDFLAT-ATAKYNMGFWKPGSGIIHQIVLE----------NY 185
++ +A NKE + FL +TA NM PGSGI+HQ+ LE
Sbjct: 140 ENAVQANMELEFQRNKERFAFLKWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVFNTKGL 199
Query: 186 AFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRMNGW 245
+P + ++GTDSHT +A M + P ++G KL G+M
Sbjct: 200 LYPDS-VVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLAGKMRNG 258
Query: 246 TSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNK 305
+ D++L + E++G+G+ S TI NM E GAT FP +
Sbjct: 259 VTATDLVLTVTQMLRKHGVVGKFVEFYGNGMSGLSLADRATIANMSPEYGATMGFFPVDH 318
Query: 306 SMIDYLDATGR-DKIAQFAQLYHK------DLLSADEGAEYDEIIEIDLNTLEPYVNGPF 358
+ YL TGR D+ + Y + D + Y +E++L+ +EP ++GP
Sbjct: 319 VTLQYLKLTGRSDETVAMIEAYLRANNMFVDYNEPQQDRVYSSYLELNLDDVEPCISGPK 378
Query: 359 TPDLATPISKMK---------DVAVK-----------------NNWPLEVK-----VGLI 387
P + +MK V K + P E+K + I
Sbjct: 379 RPHDRVTLKEMKADWHSCLDSKVGFKGFAIPKEAQEKVVNFSFDGQPAELKHGSVVIAAI 438
Query: 388 GSCTNSSYED-MSRAASVVKDAATHGLKSKSIF--TVTPGSEQIRATIARDGQLETFKEF 444
SCTN+S M A V K A GL+ K ++ PGS + + + G E E
Sbjct: 439 TSCTNTSNPSVMLGAGLVAKKACDLGLQVKPWIKTSLAPGSGVVTKYLLKSGLQEYLNEQ 498
Query: 445 GGTVLANACGPCIGQWDRQDIKKG---DKNTIVS----SFNRNFTARNDGNPDTH-SFVA 496
G ++ C CIG + G +N IV+ S NRNF R +P T +++A
Sbjct: 499 GFNIVGYGCTTCIGNSGEINESVGAAITENDIVAAAVLSGNRNFEGR--VHPLTRANYLA 556
Query: 497 SPEITTAFAIAGDLRFNPLTDTL-KDKDGNEFMLKP--PTGVGLP--------------- 538
SP + A+A+AG + + T+ + K K+G + L+ PT +
Sbjct: 557 SPPLVVAYALAGTVNIDFETEPIGKGKNGKDVFLRDIWPTTEEIAEVVQSSVLPDMFRAT 616
Query: 539 ----VKGYDPGENTYQAPPK-----DRSSVTVQVSPTSDRLQLLKPFKAWDGKDAFDMPI 589
KG +P N P D +S + P + + P + KDA+
Sbjct: 617 YESITKG-NPMWNKLSVPENTLYSWDPNSTYIH-EPPYFKDMTMDPPGPHNVKDAY---C 671
Query: 590 LIKSLGKTTTDHISMAG---------PWLKYRGHLENISNNY-------------MIGAI 627
L+ TTDHIS AG +L RG N+Y I
Sbjct: 672 LLNFGDSITTDHISPAGNIQKDSPAAKFLMERGVDRKDFNSYGSRRGNDEIMARGTFANI 731
Query: 628 NAENKKAN-----CVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALE 682
NK N H +GE V D A Y+ +G +++ G +G GSSR+ AA
Sbjct: 732 RIVNKLMNGEVGPKTVHIPSGEKLSVFDAAMRYKSSGEDTIILAGAEYGSGSSRDWAAKG 791
Query: 683 PRFLGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKINPDDTIDILGLT 735
P G A+I KSF RIH +NL G++PL F + D LGLT
Sbjct: 792 PMLQGVKAVIAKSFERIHRSNLVGMGIIPLCF---------KSGEDADTLGLT 835
>CE03812 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 887
Score = 172 bits (436), Expect = 2e-42
Identities = 192/754 (25%), Positives = 300/754 (39%), Gaps = 131/754 (17%)
Query: 87 ERGVSYLKLRPDRVACQDATAQMAIL---------QFMSAGLPQVAK--PLTVHCDHLIQ 135
+R + + +P RV QD T A++ Q M A ++ P+ + DH +Q
Sbjct: 68 QRNQAEIPFKPARVILQDFTGVPAVVDLAAMRDAVQNMGADPAKINPVCPVDLVIDHSVQ 127
Query: 136 AQIGGE-----KDLKRAIDINKEVYDFLATATAKY-NMGFWKPGSGIIHQIVLENYA--- 186
G K+ + N+E ++FL + + N+ PGSGI+HQ+ LE A
Sbjct: 128 VDHYGNLEALAKNQSIEFERNRERFNFLKWGSKAFDNLLIVPPGSGIVHQVNLEYLARTV 187
Query: 187 --------FPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKL 238
+P + ++GTDSHT +A VM + P+++G +L
Sbjct: 188 FVGKDGVLYPDS-VVGTDSHTTMIDGSGVLGWGVGGIEAEAVMLGQPISMVIPEVIGYEL 246
Query: 239 TGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATT 298
G ++ + D++L + E+FG GV + S TI NM E GAT
Sbjct: 247 VGTLSDTVTSTDLVLTITKNLRDLGVVGKFVEFFGTGVASLSIADRATIANMCPEYGATI 306
Query: 299 SVFPFNKSMIDYLDATGRD-----KIAQFAQLYHKDLLSADEG--AEYDEIIEIDLNTLE 351
FP + IDYL TGRD ++ Q+ + + D+ Y +++DL ++
Sbjct: 307 GFFPVDSRTIDYLTQTGRDTDYTQRVEQYLKSVGMFVNFTDDSYRPTYTTTLKLDLGSVV 366
Query: 352 PYVNGPFTP-------DLATPISK------------------MKDVAVKNNWPL------ 380
P V+GP P LA SK K V + N+
Sbjct: 367 PSVSGPKRPHDRVELASLAQDFSKGLTDKISFKAFGLKPEDATKSVTITNHGRTAELTHG 426
Query: 381 EVKVGLIGSCTNSSYEDMSRAASVV-KDAATHGLKSKSIF--TVTPGSEQIRATIARDGQ 437
V + I SCTN+S + AA +V K A GL + +++PGS + + G
Sbjct: 427 SVVIAAITSCTNTSNPSVMLAAGLVAKKAVELGLNVQPYVKTSLSPGSGVVTKYLEASGL 486
Query: 438 LETFKEFGGTVLANACGPCIGQ---WDRQDIKKGDKNTI----VSSFNRNFTARNDGNPD 490
L ++ G + C CIG D K ++N + V S NRNF R +
Sbjct: 487 LPYLEKIGFNIAGYGCMTCIGNSGPLDEPVTKAIEENNLVVAGVLSGNRNFEGRIHPHVR 546
Query: 491 THSFVASPEITTAFAIAGDLRFNPLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQ 550
+++ASP + ++I G++ + DG E L V + E +
Sbjct: 547 A-NYLASPPLAVLYSIIGNVNVDINGVLAVTPDGKEIRLADIWPTRKEVAKF---EEEFV 602
Query: 551 APP----------------KDRSSVTVQVSPTSDRLQLLKPFKAWDG--------KDAFD 586
P + V++ P D +K +DG D +
Sbjct: 603 KPQFFREVYANIELGSTEWQQLECPAVKLYPWDDASTYIKKVPFFDGMTSELPSQSDIVN 662
Query: 587 MPILIKSLGKTTTDHISMAGP---------WLKYRGHLENISNNY-------------MI 624
+L+ TTDHIS AG +L RG N Y
Sbjct: 663 AHVLLNLGDSVTTDHISPAGSISKTSPAARFLAGRGVTPRDFNTYGARRGNDEIMARGTF 722
Query: 625 GAINAENKKANCV----KHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAA 680
I NK A+ V H +GE + D A+ Y+DAGI +++ G+ +G GSSR+ AA
Sbjct: 723 ANIRLVNKLASKVGPITLHVPSGEELDIFDAAQKYKDAGIPAIILAGKEYGCGSSRDWAA 782
Query: 681 LEPRFLGGFAIITKSFARIHETNLKKQGMLPLNF 714
P G A+I +SF RIH +NL G++P +
Sbjct: 783 KGPFLQGVKAVIAESFERIHRSNLIGMGIIPFQY 816
>7300911 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 902
Score = 166 bits (421), Expect = 1e-40
Identities = 213/820 (25%), Positives = 330/820 (39%), Gaps = 149/820 (18%)
Query: 93 LKLRPDRVACQDATAQMAILQFMS--------AGLPQVAKPLT---VHCDHLIQAQIGGE 141
+ +P RV QD T A++ F + G P+ P+ + DH +Q
Sbjct: 82 VSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDFVRS 141
Query: 142 KDL-----KRAIDINKEVYDFLATATAKY-NMGFWKPGSGIIHQIVLENYA--------- 186
D NKE + FL + NM PGSGI+HQ+ LE A
Sbjct: 142 SDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSS 201
Query: 187 -------FPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLT 239
+P + ++GTDSHT +A VM + + P+++G +L
Sbjct: 202 ADGSKILYPDS-VVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLE 260
Query: 240 GRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTS 299
G++ + D++L + E++G GV S TI NM E GAT
Sbjct: 261 GKLGPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVG 320
Query: 300 VFPFNKSMIDYLDATGR-DKIAQFAQLYHK------DLLSADEGAEYDEIIEIDLNTLEP 352
FP +++ + Y+ T R +K + Y K D D+ +Y E + +DL+T+
Sbjct: 321 YFPIDENTLSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVT 380
Query: 353 YVNGPFTPDLATPISKMKD---------------------VAVKNNWPLE---------- 381
V+GP P +S M + +A + +
Sbjct: 381 SVSGPKRPHDRVSVSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHG 440
Query: 382 -VKVGLIGSCTNSSYED-MSRAASVVKDAATHGLKSKSIF--TVTPGSEQIRATIARDGQ 437
V + I SCTN+S M A + K+A GL +++PGS + + G
Sbjct: 441 SVVIAAITSCTNTSNPSVMLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGV 500
Query: 438 LETFKEFGGTVLANACGPCIGQ---WDRQDIKKGDKNTIVS----SFNRNFTARNDGNPD 490
+ ++ G ++ C CIG D + +KN +V S NRNF R +P+
Sbjct: 501 IPYLEQLGFDIVGYGCMTCIGNSGPLDENVVNTIEKNGLVCCGVLSGNRNFEGRI--HPN 558
Query: 491 TH-SFVASPEITTAFAIAG----DLRFNPLTDTLKDKDGNEFMLKP--PTGVGLPV---K 540
T +++ASP + A+AIAG D PL D +G E L+ PT + K
Sbjct: 559 TRANYLASPLLVIAYAIAGRVDIDFEIEPLG---VDSNGKEVFLRDIWPTRSEIQEVEHK 615
Query: 541 GYDPG--ENTY---QAPPKDRSSVTVQVS---PTSDRLQLLK--PF-----KAWDGKDAF 585
P + Y Q +D ++ V S P S+ +K PF +A
Sbjct: 616 HVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEISTYIKLPPFFEGMTRALPKLKGI 675
Query: 586 DMPILIKSLG-KTTTDHISMAGP---------WLKYRGHLENISNNY------------- 622
+ + LG TTDHIS AG +L RG N+Y
Sbjct: 676 EKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMARG 735
Query: 623 MIGAINAENKKAN----CVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREH 678
I NK A+ H +GE + D A Y G V++ G+++G GSSR+
Sbjct: 736 TFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVGKDYGSGSSRDW 795
Query: 679 AALEPRFLGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYD--KINPDDTIDI-LGLT 735
AA P LG A+I +S+ RIH +NL G++PL F + D K++ + +I L
Sbjct: 796 AAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNIVLPEG 855
Query: 736 TLAPGKNLIMRVHPKEGEAWETPLSHTFNAE-QIEWFKAG 774
L PG+ + + +G +ET L F+ E I ++K G
Sbjct: 856 ELKPGQRIQV---DADGNVFETTL--RFDTEVDITYYKNG 890
>7299336 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 899
Score = 155 bits (391), Expect = 3e-37
Identities = 201/771 (26%), Positives = 308/771 (39%), Gaps = 151/771 (19%)
Query: 93 LKLRPDRVACQDATAQMAILQFMS--------AGLPQVAKPLT---VHCDHLIQAQIGGE 141
+ +P RV QD T A++ F + G P+ P+ + DH +Q
Sbjct: 80 VSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQVDFARA 139
Query: 142 KDL-----KRAIDINKEVYDFLAT-ATAKYNMGFWKPGSGIIHQI--------VLENYAF 187
D + NKE + FL A A NM PGSGI+HQ+ V EN A
Sbjct: 140 PDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDAT 199
Query: 188 PGALI------IGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGR 241
G+ I +GTDSHT +A VM + + P+++G KL G+
Sbjct: 200 DGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGK 259
Query: 242 MNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVF 301
++ + D++L + E++G GV S TI NM E GAT F
Sbjct: 260 LSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYF 319
Query: 302 PFNKSMIDYLDATGR-----DKIAQF--AQLYHKDLLSADEGAEYDEIIEIDLNTLEPYV 354
P +++ + Y+ T R D I Q+ A ++ A + ++ + I +DL+T+ V
Sbjct: 320 PIDENTLGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSV 379
Query: 355 NGPFTPDLATPISKMKD---------VAVKN--------------NWP---------LEV 382
+GP P +S M + V K W V
Sbjct: 380 SGPKRPHDRVSVSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSV 439
Query: 383 KVGLIGSCTNSSYED-MSRAASVVKDAATHGLKSKSIF--TVTPGSEQIRATIARDGQLE 439
+ I SCTN+S M A + K A GL +++PGS + + G +
Sbjct: 440 VIAAITSCTNTSNPSVMLGAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIP 499
Query: 440 TFKEFGGTVLANACGPCIGQ---WDRQDIKKGDKNTIVS----SFNRNFTARNDGNPDTH 492
++ G ++ C CIG + + +KN +V S NRNF R +P+T
Sbjct: 500 YLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRI--HPNTR 557
Query: 493 -SFVASPEITTAFAIAG----DLRFNPLTDTLKDKDGNEFMLKP--PTGVGLPVKGYDPG 545
+++ASP + A+AIAG D PL D +G L+ PT +
Sbjct: 558 ANYLASPLLVIAYAIAGRVDIDFEKEPLG---VDANGKNVFLQDIWPTRSEI-----QEV 609
Query: 546 ENTYQAPPK-----------DRSSVTVQVSP------TSDRLQLLKPFKAWDGKDAFDMP 588
EN + P + T+QVS ++D + +P ++G D+P
Sbjct: 610 ENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADSTYIKRP-PFFEGMTR-DLP 667
Query: 589 IL--------IKSLG-KTTTDHISMAGP---------WLKYRGHLENISNNYMI----GA 626
L + LG TTDHIS AG +L R N+Y A
Sbjct: 668 KLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFNSYGSRRGNDA 727
Query: 627 INAENKKANC-------------VKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEG 673
I + AN H + E + D A YR+ G V++ G+++G G
Sbjct: 728 IMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGKDYGSG 787
Query: 674 SSREHAALEPRFLGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKIN 724
SSR+ AA P LG A+I +S+ RIH +NL G++PL F + + +N
Sbjct: 788 SSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLN 838
>Hs17478037 [AJ] KOG0452 RNA-binding translational regulator IRP (aconitase
superfamily)
Length = 963
Score = 151 bits (381), Expect = 4e-36
Identities = 172/723 (23%), Positives = 288/723 (39%), Gaps = 152/723 (21%)
Query: 151 NKEVYDFLATATAKY-NMGFWKPGSGIIHQIVLE----------NYAFPGALIIGTDSHT 199
N+E F ++ + N+ PG+G+ HQI LE + FP + ++GTDSH
Sbjct: 225 NRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLLFPDS-VVGTDSHI 283
Query: 200 PNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRMNGWTSPKDIILKLAXXX 259
+ VM L L P+++G +LTG N + + D++L +
Sbjct: 284 TMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGITKHL 343
Query: 260 XXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIDYLDATGRDK- 318
E+FG GV S TI NM E GA S FP + + +L+ TG K
Sbjct: 344 RQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKA 403
Query: 319 -------IAQFAQLYHKDLLSADEGAEYDEIIEIDLNTLEPYVNGPFTPDLATPISKMK- 370
+ +L+ D S+ E EY ++I+I+LN++ P V+GP P ++ MK
Sbjct: 404 KLESMETYLKAVKLFRNDQNSSGE-PEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKS 462
Query: 371 ---------------DVAVKNNWPL---------------EVKVGLIGSCTNSSYEDMSR 400
+A + + V + + SCTN+ +
Sbjct: 463 DFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVML 522
Query: 401 AASVV-KDAATHGLKSKSIF--TVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCI 457
AA ++ K A GL+ K +++PGS + ++ G L + G ++ C C+
Sbjct: 523 AAGLLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICV 582
Query: 458 GQWD------RQDIKKGDKNTI-VSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDL 510
G +K+GD T + S N+NF R + +++ASP + A+AIAG +
Sbjct: 583 GNTAPLSDAVLNAVKQGDLVTCGILSGNKNFEGRL-CDCVRANYLASPPLVVAYAIAGTV 641
Query: 511 RFNPLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTYQAPPKDRSSVTVQVSPTSDRL 570
+ T+ L G + PTG + + P ++ +++ D++
Sbjct: 642 NIDFQTEPL----GTD-----PTGKNIYLHDIWPSREEVHRVEEEHVILSM-FKALKDKI 691
Query: 571 QLLKPFKAWDGKDAFDM------------------------PILIKSL----------GK 596
++ K W+ +A D PI ++++
Sbjct: 692 EMGN--KRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDS 749
Query: 597 TTTDHISMAG---------PWLKYRGHLENISNNYMIGAINAEN---------------- 631
TTDHIS AG +L RG N+Y GA +
Sbjct: 750 VTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSY--GARRGNDAVMTRGTFANIKLFNK 807
Query: 632 ---KKANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGG 688
K A H +G+ V + A Y+ GI +++ G+ +G G+SR+ AA P LG
Sbjct: 808 FIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGV 867
Query: 689 FAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKINPDDTIDILGLTTLAPGKNLIMRVH 748
A++ +S+ +IH+ +L G+ PL F P + D LGL+ G+
Sbjct: 868 KAVLAESYEKIHKDHLIGIGIAPLQFL---------PGENADSLGLS----GRETFSLTF 914
Query: 749 PKE 751
P+E
Sbjct: 915 PEE 917
>SPAC343.16 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 721
Score = 142 bits (359), Expect = 2e-33
Identities = 120/456 (26%), Positives = 199/456 (43%), Gaps = 36/456 (7%)
Query: 66 PLTYAEKILYGHLDDPHGQEIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKP 125
P T EKI+ + + R Y+ ++P D + +A L+FM G +V
Sbjct: 60 PQTITEKIVQKFAQNIPENKYVRSGDYVTIKPKHCMSHDNSWPVA-LKFMGIGAKKVFDN 118
Query: 126 LTVHC--DHLIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNMGFWKPGSGIIHQIVLE 183
+ C DH D++ + N Y + + + F+ G GI HQI++E
Sbjct: 119 RQIVCTLDH----------DVQNKSEANLRKYKNIESFAKGQGIDFYPAGRGIGHQIMVE 168
Query: 184 N-YAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTGRM 242
YA PG++ + +DSH+ DA + + + P I V L G++
Sbjct: 169 QGYAMPGSMAVASDSHSNTYGGVGCLGTPIVRTDAAAIWATGQTWWQIPPIARVNLVGQL 228
Query: 243 NGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSVFP 302
S KDII+ L E++G+G+++ S TI NM E GA + +FP
Sbjct: 229 PKGLSGKDIIVSLCGAFNHDEVLNHAIEFYGEGLNSLSIESRLTIANMTTEWGALSGLFP 288
Query: 303 FNKSMIDYLDATGRDKIAQFAQLYHKDL-------LSADEGAEYDEIIEIDLNTLEPYVN 355
++ ++ + + + ++ + L + ADEGA Y + + +DL+TL P V+
Sbjct: 289 TDEKLLAWYEDRLKFLGPNHPRVNRETLDAIKASPILADEGAFYAKHLILDLSTLSPAVS 348
Query: 356 GPFTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVK-DAATHGLK 414
GP + A + +K + SCTN D+ AA VK G++
Sbjct: 349 GP------NSVKVYNSAATLEKKDILIKKAYLVSCTNGRLSDIHDAAETVKGKKVADGVE 402
Query: 415 SKSIFTVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCIGQWDRQDIKKGDKNTIV 474
F V S ++ A ++G +T + G L CGPCIG +K G+ +
Sbjct: 403 ----FYVGAASSEVEAAAQKNGDWQTLIDSGARTLPAGCGPCIGLGTGL-LKDGEVG--I 455
Query: 475 SSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDL 510
S+ NRNF R G+ + +++ASP + A AIAG +
Sbjct: 456 SATNRNFKGRM-GSREALAYLASPAVVAASAIAGKI 490
>YDR234w [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 693
Score = 142 bits (358), Expect = 2e-33
Identities = 175/678 (25%), Positives = 276/678 (39%), Gaps = 91/678 (13%)
Query: 64 GRPLTYAEKILYGH-LDDPHGQEIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQV 122
G+ LT EKI+ + ++ P G+ + G Y+ ++P D + +A L+FM G ++
Sbjct: 20 GQNLT--EKIVQSYAVNLPEGKVVHSG-DYVSIKPAHCMSHDNSWPVA-LKFMGLGATKI 75
Query: 123 AKP--LTVHCDHLIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNMGFWKPGSGIIHQI 180
P + DH IQ + EK+L + Y + K+++ + G GI HQI
Sbjct: 76 KNPSQIVTTLDHDIQNK--SEKNLTK--------YKNIENFAKKHHIDHYPAGRGIGHQI 125
Query: 181 VLEN-YAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLT 239
++E YAFP + + +DSH+ DA + + + P + V+L
Sbjct: 126 MIEEGYAFPLNMTVASDSHSNTYGGLGSLGTPIVRTDAAAIWATGQTWWQIPPVAQVELK 185
Query: 240 GRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTS 299
G++ S KDII+ L E+ GD ++ TI NM E GA +
Sbjct: 186 GQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPIDHRLTIANMTTEWGALSG 245
Query: 300 VFPFNKSMIDY----LDATGRDKIAQF------AQLYHKDLLSADEGAEYDEIIEIDLNT 349
+FP +K++ID+ L G + + A + AD+ A Y + + IDL T
Sbjct: 246 LFPVDKTLIDWYKNRLQKLGTNNHPRINPKTIRALEEKAKIPKADKDAHYAKKLIIDLAT 305
Query: 350 LEPYVNGPFTPDLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAA 409
L YV+GP + ++ + + +K N K L+ SCTNS D+ AA VV
Sbjct: 306 LTHYVSGPNSVKVSNTVQDLSQQDIKIN-----KAYLV-SCTNSRLSDLQSAADVVCPTG 359
Query: 410 THGLKSKSI----FTVTPGSEQIRATIARDGQLETFKEFGGTVLANACGPCIGQWDRQDI 465
+K F V S +I A + G E + G L + CGPCIG +
Sbjct: 360 DLNKVNKVAPGVEFYVAAASSEIEADARKSGAWEKLLKAGCIPLPSGCGPCIG-LGAGLL 418
Query: 466 KKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAGDLRFNPLTDTLKDKDGN 525
+ G+ +S+ NRNF R G+ D +++ASP + A A+ G + + + L +
Sbjct: 419 EPGEVG--ISATNRNFKGRM-GSKDALAYLASPAVVAASAVLG--KISSPAEVLSTSE-- 471
Query: 526 EFMLKPPTGVGLPVKGYDPGENTYQAPPKDRSSVTVQVSPTSDRLQLLKPFKAWDGKDAF 585
P +GV + EN P V Q +++L+ F F
Sbjct: 472 ----IPFSGVKTEII-----EN-----PVVEEEVNAQTEAPKQSVEILEGFPR-----EF 512
Query: 586 DMPILIKSLGKTTTDHISMAGPWLKYRGHLENISNNYMIGAINAENKKANCVKHHYTGEY 645
+++ TD I Y G Y + K A +Y E+
Sbjct: 513 SGELVLCDADNINTDGI--------YPG-------KYTYQDDVPKEKMAQVCMENYDAEF 557
Query: 646 AGVPDTARAYRDAGIRWVVIGGENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLK 705
R G +V+ G NFG GSSRE AA G +++ SF I N
Sbjct: 558 -------RTKVHPGD--IVVSGFNFGTGSSREQAATALLAKGINLVVSGSFGNIFSRNSI 608
Query: 706 KQGMLPLNFAEPAAYDKI 723
+L L PA K+
Sbjct: 609 NNALLTLEI--PALIKKL 624
>YGL009c [E] KOG0454 3-isopropylmalate dehydratase (aconitase superfamily)
Length = 779
Score = 117 bits (294), Expect = 5e-26
Identities = 170/708 (24%), Positives = 271/708 (38%), Gaps = 91/708 (12%)
Query: 72 KILYGHLDDPHGQEIERGVSYLKLRPDRVACQDATAQMAILQFMSAGLPQVAKPLTVHC- 130
+ LY + D H + S+L L DR + T+ A +AG K V C
Sbjct: 10 RTLYDKVFDAHVVHQDENGSFL-LYIDRHLVHEVTSPQAFEGLENAG----RKVRRVDCT 64
Query: 131 ----DHLIQAQIGGEKDLKRAIDINKEVYDFLATATAKYNM--------GFWKPGSGIIH 178
DH I + K+ K K+ L T + N+ G GI+H
Sbjct: 65 LATVDHNIPTE--SRKNFKSLDTFIKQTDSRLQVKTLENNVKQFGVPYFGMSDARQGIVH 122
Query: 179 QI-VLENYAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVK 237
I E + PG ++ DSHT + V++ K M +
Sbjct: 123 TIGPEEGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRIT 182
Query: 238 LTGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGAT 297
+ G+++ + KD+IL + E+ G+ ++ S ++CNM E GA
Sbjct: 183 VNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEAGAR 242
Query: 298 TSVFPFNKSMIDYLDATGRDKIAQFAQ----LYHKDLLSADEGAEYDEIIEIDLNTLEPY 353
+ +++ Y GR + A+ + + L DEGA++D I I+ + P
Sbjct: 243 AGMIKPDETTFQY--TKGRPLAPKGAEWEKAVAYWKTLKTDEGAKFDHEINIEAVDVIPT 300
Query: 354 VNGPFTPDLATPIS--------------------KMKDVAVKNNWPLE-VKVG--LIGSC 390
+ +P A PI+ + + ++ N PL+ +KV IGSC
Sbjct: 301 ITWGTSPQDALPITGSVPDPKNVTDPIKKSGMERALAYMGLEPNTPLKSIKVDKVFIGSC 360
Query: 391 TNSSYEDMSRAASVVKDAATHGLKSKSIFTVTPGSEQIRATIARDGQLETFKEFGGTVLA 450
TN ED+ AA+VV+ + + V PGS ++ +G + F+E G
Sbjct: 361 TNGRIEDLRSAAAVVRGQKL--ASNIKLAMVVPGSGLVKKQAEAEGLDKIFQEAGFEWRE 418
Query: 451 NACGPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAG-- 508
C C+G DI + S+ NRNF R TH + SP + A IAG
Sbjct: 419 AGCSICLGM--NPDILDAYER-CASTSNRNFEGRQGALSRTH--LMSPAMAAAAGIAGHF 473
Query: 509 -DLRFNPLTDTLKDKDGNEFMLKPPTGVGLPVKGYDPGENTY-QAPPKDRSS-------V 559
D+R D +D+ + + L YD E + P+D ++ V
Sbjct: 474 VDIREFEYKD--QDQSSPKVEVTSEDEKELESAAYDHAEPVQPEDAPQDIANDELKDIPV 531
Query: 560 TVQVSPTSDRLQLLKPFKAWDGKDAFDMPILIKSLGKTTTDHISMAGPWLKYRGHLENIS 619
+P +KPF +G A L K D ++ + L+ I
Sbjct: 532 KSDDTPAKPSSSGMKPFLTLEGISA--------PLDKANVDTDAIIP-----KQFLKTIK 578
Query: 620 NNYMIGAINAE--NKKANCVKHHYTGEYAGVPDTARAYRDAGIRWVVIGGENFGEGSSRE 677
+ + E +K + K T V +R+A I +V+ G+NFG GSSRE
Sbjct: 579 RTGLKKGLFYEWRFRKDDQGKDQETDFVLNV----EPWREAEI--LVVTGDNFGCGSSRE 632
Query: 678 HAALEPRFLGGFAIITKSFARIHETNLKKQGMLPLNFAEPAAYDKINP 725
HA + G +II S+ I N K G+LP+ + DK+ P
Sbjct: 633 HAPWALKDFGIKSIIAPSYGDIFYNNSFKNGLLPIRLDQQIIIDKLIP 680
>At4g13430 [E] KOG0454 3-isopropylmalate dehydratase (aconitase superfamily)
Length = 509
Score = 106 bits (264), Expect = 2e-22
Identities = 102/397 (25%), Positives = 160/397 (39%), Gaps = 47/397 (11%)
Query: 131 DHLIQAQIGGEKDLKRAIDINKE---------VYDFLATATAKYNMGFWKPGSGIIH-QI 180
DH I +K R +DI +E YD K N + G+ H +
Sbjct: 131 DHYI---FTADKRANRNVDIMREHCREQNIKYFYDITDLGNFKANPDY----KGVCHVAL 183
Query: 181 VLENYAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKIMGVKLTG 240
E + PG +++GTDSHT DA V+ LK P M L G
Sbjct: 184 AQEGHCRPGEVLLGTDSHTCTAGAFGQFATGIGNTDAGFVLGTGKILLKVPPTMRFILDG 243
Query: 241 RMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAEIGATTSV 300
M + KD+IL++ E+ G +++ S T+CNM E G V
Sbjct: 244 EMPSYLQAKDLILQIIGEISVAGATYKTMEFSGTTIESLSMEERMTLCNMVVEAGGKNGV 303
Query: 301 FPFNKSMIDYLDATGRDKIAQFAQLYHKDLLSADEGAEYDEIIEIDLNTLEPYVNGPFTP 360
P + + ++Y++A ++ F +Y +D A + D++ LEP V P +P
Sbjct: 304 IPPDATTLNYVEAC---ILSCFLPVY------SDGNASFVADYRFDVSKLEPVVAKPHSP 354
Query: 361 DLATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAATHGLKSKSIFT 420
D + KDV + + IGSCT ED AA + A G K K
Sbjct: 355 DNRALARECKDVKIDRVY--------IGSCTGGKTEDFMAAAKLFHAA---GRKVKVPTF 403
Query: 421 VTPGSEQIRATI------ARDGQ--LETFKEFG-GTVLANACGPCIGQWDRQDIKKGDKN 471
+ P ++++ + G+ + F+E G T + +CG C+G + +
Sbjct: 404 LVPATQKVWMDVYALPVPGAGGKTCAQIFEEAGCDTPASPSCGACLGGPADTYARLNEPQ 463
Query: 472 TIVSSFNRNFTARNDGNPDTHSFVASPEITTAFAIAG 508
VS+ NRNF R G+ + ++ASP A A+ G
Sbjct: 464 VCVSTTNRNFPGRM-GHKEGQIYLASPYTAAASALTG 499
>SPAC9E9.03 [E] KOG0454 3-isopropylmalate dehydratase (aconitase superfamily)
Length = 758
Score = 93.6 bits (231), Expect = 1e-18
Identities = 97/366 (26%), Positives = 152/366 (41%), Gaps = 41/366 (11%)
Query: 175 GIIHQIVLEN-YAFPGALIIGTDSHTPNXXXXXXXXXXXXXXDAVDVMSDLAWELKAPKI 233
GI+H I E + PG ++ DSHT + V++ + K
Sbjct: 118 GIVHVIGPEQGFTLPGTTLVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTILQRKSKN 177
Query: 234 MGVKLTGRMNGWTSPKDIILKLAXXXXXXXXXXXXXEYFGDGVDTFSATGMGTICNMGAE 293
M +++ G++ + KD+IL + E+ G+ ++ S ++CNM E
Sbjct: 178 MRIRVNGKLPEGIASKDLILHIIGVIGTAGGTGSVIEFCGEAIEGLSMEARMSMCNMSIE 237
Query: 294 IGATTSVFPFNKSMIDYLD----ATGRDKIAQFAQLYHKDLLSADEGAEYDEIIEIDLNT 349
GA + + + +Y+ A D Q A Y K L S DE A+YD +EI+
Sbjct: 238 AGARAGMIAPDATTFEYVKNRPLAPKGDDWEQ-AVAYWKTLRS-DENAKYDIEVEINAAD 295
Query: 350 LEPYVNGPFTPDLATPIS-KMKDVA-VKNN-----------------------WPLEVKV 384
+ P V +P PI+ + D A VK+N +P++ KV
Sbjct: 296 VLPTVTWGTSPQDVIPINGNIPDPAHVKDNVRAASIQRSLEYMGLKPNTSIVSYPID-KV 354
Query: 385 GLIGSCTNSSYEDMSRAASVVKDAATHGLKSKSIFTVTPGSEQIRATIARDGQLETFKEF 444
IGSCTNS ED+ AA+VVK ++ + PGS ++ +G + F E
Sbjct: 355 -FIGSCTNSRIEDLRLAAAVVKGRKVAANVKDAM--IVPGSGLVKKMAEAEGLDQIFIEA 411
Query: 445 GGTVLANACGPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPDTHSFVASPEITTAF 504
G C C+G + +K ++ S+ NRNF R TH + SP + A
Sbjct: 412 GFDWREAGCSMCLGM-NPDQLKPYER--CASTSNRNFEGRQGAKGRTH--LVSPAMAAAA 466
Query: 505 AIAGDL 510
AI G L
Sbjct: 467 AIKGHL 472
>Hs17450976 [CE] KOG0453 Aconitase/homoaconitase (aconitase superfamily)
Length = 215
Score = 69.7 bits (169), Expect = 2e-11
Identities = 36/78 (46%), Positives = 46/78 (58%), Gaps = 2/78 (2%)
Query: 357 PFTPDL--ATPISKMKDVAVKNNWPLEVKVGLIGSCTNSSYEDMSRAASVVKDAATHGLK 414
P P L A + ++ V K WPL++KVGLI SCTNSSYED+ + ++ K HGLK
Sbjct: 96 PLLPHLNSAHTVEEVGTVVEKEGWPLDIKVGLINSCTNSSYEDIRCSTAMAKQVLAHGLK 155
Query: 415 SKSIFTVTPGSEQIRATI 432
KS T GS+QI I
Sbjct: 156 CKSQLTTALGSKQIYTNI 173
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,919,440
Number of Sequences: 60738
Number of extensions: 2073517
Number of successful extensions: 4059
Number of sequences better than 1.0e-05: 25
Number of HSP's better than 0.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3937
Number of HSP's gapped (non-prelim): 50
length of query: 788
length of database: 30,389,216
effective HSP length: 114
effective length of query: 674
effective length of database: 23,465,084
effective search space: 15815466616
effective search space used: 15815466616
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)