ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4313 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4313 1522475 1523920 482
(482 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL221w [G] KOG2504 Monocarboxylate transporter 420 e-117
YNL125c [G] KOG2504 Monocarboxylate transporter 177 3e-44
Hs20559959 [G] KOG2504 Monocarboxylate transporter 72 1e-12
YOR306c [G] KOG2504 Monocarboxylate transporter 72 2e-12
Hs22064599 [G] KOG2504 Monocarboxylate transporter 64 5e-10
Hs7019529 [G] KOG2504 Monocarboxylate transporter 57 6e-08
7292012 [G] KOG2504 Monocarboxylate transporter 57 6e-08
Hs18699730 [G] KOG2504 Monocarboxylate transporter 55 2e-07
Hs4759120 [G] KOG2504 Monocarboxylate transporter 54 5e-07
CE04864 [G] KOG2504 Monocarboxylate transporter 54 7e-07
7295764 [G] KOG2504 Monocarboxylate transporter 54 7e-07
Hs4759118 [G] KOG2504 Monocarboxylate transporter 53 1e-06
7290288 [G] KOG2504 Monocarboxylate transporter 52 2e-06
Hs5730045 [G] KOG2504 Monocarboxylate transporter 52 2e-06
CE29573 [G] KOG2504 Monocarboxylate transporter 52 2e-06
CE02803 [G] KOG2504 Monocarboxylate transporter 52 2e-06
7303008 [G] KOG2504 Monocarboxylate transporter 51 4e-06
>YKL221w [G] KOG2504 Monocarboxylate transporter
Length = 473
Score = 420 bits (1079), Expect = e-117
Identities = 211/442 (47%), Positives = 280/442 (62%), Gaps = 2/442 (0%)
Query: 42 IQIPDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXX 101
I++PDGGYGW + + + NF TWG+NSG+AIYL++YLE+N F G +KLD
Sbjct: 33 IEVPDGGYGWFILLAFILYNFSTWGANSGYAIYLAHYLENNTFAGGSKLDYASIGGLAFS 92
Query: 102 XXXXXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFI 161
P+I + S++ I +GI+ QGAALLL AF+ LW+++LTQG+L+ FGLAFI
Sbjct: 93 CGLFFAPVITWLYHIFSIQFIIGLGILFQGAALLLAAFSVTLWEIYLTQGVLIGFGLAFI 152
Query: 162 SIPATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEVKSLKWALISQCIINSV 221
IP+ +I WFR KR+ FNL MQ I++ + +KWALI+QCII +
Sbjct: 153 FIPSVTLIPLWFRNKRSLASGIGTAGSGLGGIVFNLGMQSILQKRGVKWALIAQCIICTS 212
Query: 222 LSTVALLLIRTRDNVVRETAKEMP-KFFELSLLKNAAVWFLIFYVSCTMLGYVVLLYSLS 280
LST+AL+L RT +R+ + + + +L N AVW L +VS MLGYVVLLYSLS
Sbjct: 213 LSTIALMLTRTTHQGLRQHKRSYKFELLDYDVLSNFAVWLLFGFVSFAMLGYVVLLYSLS 272
Query: 281 AFAVSLGYSQKQGSIVSCMISVGGFVFRPAVGHVADKYGPXXXXXXXXXXXXXXCLAMWI 340
F VSLGY+ KQGS VSCM+SVG + RP VGH+ADKYG C AMWI
Sbjct: 273 DFTVSLGYTSKQGSYVSCMVSVGSLLGRPIVGHIADKYGSLTVGMILHLVMAILCWAMWI 332
Query: 341 PCRNLATAIAFGLLSGALMGSIWPLQTSIISRIGGLNKLPAIYSFTWPCIGMMSIVSPII 400
PC+NLATAI FGLL G++MG+IWP SI++RI GL KLP + TW + ++V+PII
Sbjct: 333 PCKNLATAIRFGLLVGSIMGTIWPTIASIVTRIVGLQKLPGTFGSTWIFMAAFALVAPII 392
Query: 401 GLRLRSNDPTVANQYVNTAIFSGMGYFGAAFFLWMIRGYLIARDKLAMVAKTGHDDGELH 460
GL LRS D T N Y TAIF G YFG + W++RG++IARD++A+ D ELH
Sbjct: 393 GLELRSTD-TNGNDYYRTAIFVGFAYFGVSLCQWLLRGFIIARDEIAVREAYSADQNELH 451
Query: 461 LHVTIPELLKGLLTIGRLPRKV 482
L+V + + K L +LPR+V
Sbjct: 452 LNVKLSHMSKCLFRYKQLPRRV 473
>YNL125c [G] KOG2504 Monocarboxylate transporter
Length = 673
Score = 177 bits (449), Expect = 3e-44
Identities = 105/405 (25%), Positives = 186/405 (45%), Gaps = 9/405 (2%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
PDGGYGWVV C F F TWG N+ F + L+YYL + +PGA+K D
Sbjct: 207 PDGGYGWVVTFCVFLTMFSTWGCNASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQ 266
Query: 105 XXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIP 164
PL+ + ++T++ G + AA LL +F TKLWQ+++TQG +V ++ I +P
Sbjct: 267 LLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVP 326
Query: 165 ATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIV-EVKSLKWALISQCIINSVLS 223
AT ++ WF +KR + LA +++ + + +W L I S+
Sbjct: 327 ATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISV 386
Query: 224 TVALLLIRTRD-------NVVRETAKEMPKFFELSLLKNAAVWFLIFYVSCTMLGYVVLL 276
VA+ L++ R+ R +++ F L ++ V + + + Y +++
Sbjct: 387 LVAIALLKERNPTPAIGLKSPRAMFEQLKAMFSLKVITKPFVVLIALWFMFALFAYNMMV 446
Query: 277 YSLSAFAVSLGYSQKQGSIVSCMISVGGFVFRPAVGHVADKYGPXXXXXXXXXXXXXXCL 336
++LS++A+S G S S ++ +++ + RP +G DK+G
Sbjct: 447 FTLSSYAISKGLSSHDASTLTAILNGSQSIGRPLMGLAGDKFGRANVTIVLTTLLTIYMF 506
Query: 337 AMWIPCRNLATAIAFGLLSGALMGSIWPLQTSIISRIGGLNKLPAIYSFTWPCIGMMSIV 396
A WIP I F +L G+ +G + T +I+ + + ++F C +V
Sbjct: 507 AFWIPAHTFVQLIFFSILVGSCVGVANVMNTVLIADMVKPEEFLPAWAFVNYCGAPFLLV 566
Query: 397 SPIIGLRLRSNDPTVANQYVNTAIFSGMGYFGAAFFLWMIRGYLI 441
+I L + + +N Y++ IF G + A + ++R Y I
Sbjct: 567 CEVIAQAL-TVEKDKSNPYLHAQIFCGCCFIAALILISILREYSI 610
>Hs20559959 [G] KOG2504 Monocarboxylate transporter
Length = 426
Score = 72.4 bits (176), Expect = 1e-12
Identities = 79/365 (21%), Positives = 145/365 (39%), Gaps = 25/365 (6%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
PDGG+GWVV + FF + +G F ++ ++ + A
Sbjct: 8 PDGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAAR---VSWIASIGIAVQQ 64
Query: 105 XXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIP 164
P+ + K + + G +L +LL +FAT L ++L+ GLL G A P
Sbjct: 65 FGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAP 124
Query: 165 ATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEVKSLKWALISQCIINSVLST 224
+S +F R+R+ F Q ++ + + +L+ ++ L
Sbjct: 125 TLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSALS--LHL 182
Query: 225 VALLLIRTRDNVVRETAKEMPKFFELSLLKNAAVWFLIFYVSCTML--GYVVLLYSLSAF 282
VA + ++ + A P+ SLL + FL + V+ T++ GY + L A
Sbjct: 183 VACGALLRPPSLAEDPAVGGPRAQLTSLLHHGP--FLRYTVALTLINTGYFIPYLHLVAH 240
Query: 283 AVSLGYSQKQGSIVSCMISVGGFVFRPAVGHVADKY-GPXXXXXXXXXXXXXXCLAMW-- 339
L + + + ++++ V R G + D GP LA++
Sbjct: 241 LQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPGPVTRLLMLWTTLTGVSLALFPV 300
Query: 340 --IPCRNLATAIAFGLLSGALMGSIWPLQTSIISRIGGLNKLPAIYSFTWPCIGMMSIVS 397
P +A A+A+G SGAL PL S++ + G ++ + +G++ ++
Sbjct: 301 AQAPTALVALAVAYGFTSGALA----PLAFSVLPELIGTRRI-------YCGLGLLQMIE 349
Query: 398 PIIGL 402
I GL
Sbjct: 350 SIGGL 354
>YOR306c [G] KOG2504 Monocarboxylate transporter
Length = 521
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/438 (20%), Positives = 165/438 (37%), Gaps = 34/438 (7%)
Query: 28 NETEKYNESVDYNKIQIPDGGY-GWVVCM-CYFFLNFCTWGSNSGFAIYLSYYLESNRFP 85
++ E NE ++ P+GG+ WVV C+ L C NS I +L+ N+
Sbjct: 87 DKEEDSNEEIE----SFPEGGFKAWVVTFGCFLGLIACFGLLNSTGVI--ESHLQDNQLS 140
Query: 86 GATKLDXXXXXXXXXXXXXXXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQ 145
+ + + + +T + VG V A L A +TK W
Sbjct: 141 SESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWH 200
Query: 146 VFLTQGLLVSFGLAFISIPATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEV 205
L+ ++ FG + P ++ + +F ++R F + ++ +
Sbjct: 201 FILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSM 260
Query: 206 KS-------LKWALISQCIINSVLSTVALLLIRTRDNVVRETAKEMPKFFELSL------ 252
KS W + + ++ L T++++L++ R V E +K+ + L
Sbjct: 261 KSDTDPTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYILQ 320
Query: 253 LKNAAVWFLIFYVSCTMLGYVVLLYSLS-------AFAVSLGYSQKQGSIVSCMISVGGF 305
+A + + Y+ C +LG V S++ ++A S G S + +I+V G
Sbjct: 321 CFDAKAFLDMKYLFC-VLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGI 379
Query: 306 VFRPAVGHVADKYGPXXXXXXXXXXXXXXCLAMWIPC-RNLATAIAFGLLSGALMGSIWP 364
R G+++DK+G W+P NL L G GS++
Sbjct: 380 PGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFS 439
Query: 365 LQTSIISRIGGLNKLPAIYSFTWPCIGMMSIVS-PIIGLRLRSNDPTVANQYVNTAIFSG 423
L +I + YS + +G ++V PI G + Y+ IFSG
Sbjct: 440 LLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYI---IFSG 496
Query: 424 MGYFGAAFFLWMIRGYLI 441
+ F +A + R Y +
Sbjct: 497 LATFVSAVCYIISRAYCV 514
>Hs22064599 [G] KOG2504 Monocarboxylate transporter
Length = 579
Score = 63.9 bits (154), Expect = 5e-10
Identities = 88/396 (22%), Positives = 149/396 (37%), Gaps = 26/396 (6%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
PDGG+GWVV F +N ++G + E F + + D
Sbjct: 141 PDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAE--HFDRSAQ-DTAWISALALAVQQ 197
Query: 105 XXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIP 164
P+ + + + + VG VL + AFA+ L ++L GLL FG A + P
Sbjct: 198 AASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAP 257
Query: 165 ATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEVKSLKWALISQCIINSVLST 224
A +S +F R+R A+Q +++ + AL+ I L+
Sbjct: 258 ALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTP 317
Query: 225 V-ALLLIRTRDNVVRETAKEMPKFFELSLLKNAAVWFLIFYVSCTML--GYVVLLYSLSA 281
ALLL + LSL A F IF + ++ GY V L+
Sbjct: 318 CGALLLPLVLPGDPPAPPRSPLAALGLSLFTRRA--FSIFALGTALVGGGYFVPYVHLAP 375
Query: 282 FAVSLGYSQKQGSIVSCMISVGGFVFRPAVGHVADKYGPXXXXXXXXXXXXXXCLAMW-- 339
A+ G ++V + ++G R G +AD+ G L +W
Sbjct: 376 HALDRGLGGYGAALVVAVAAMGDAGARLVCGWLADQ-GWVPLPRLLAVFGALTGLGLWVV 434
Query: 340 --IPCRN---------LATAIAFGLLSGALMGSIWPLQTSIISRIGGLNKLPAIYSFTWP 388
+P LA A+A+GL +G+ ++ + ++ +GG+ + +
Sbjct: 435 GLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVFGVLPGLVG-VGGVVQATGLVMMLMS 493
Query: 389 CIGMMSIVSPIIG-LRLRSNDPTVANQYVNTAIFSG 423
G++ P+ G LR + D T + + I SG
Sbjct: 494 LGGLLG--PPLSGFLRDETGDFTASFLLSGSLILSG 527
>Hs7019529 [G] KOG2504 Monocarboxylate transporter
Length = 504
Score = 57.0 bits (136), Expect = 6e-08
Identities = 79/375 (21%), Positives = 141/375 (37%), Gaps = 46/375 (12%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
PDGG+GWVV F + +G +++ + R A D
Sbjct: 13 PDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALM---RDFDAGYSDTAWVSSIMLAMLY 69
Query: 105 XXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIP 164
P+ + V + + + G +L A ++L +FAT+L +++LT G+L GLA P
Sbjct: 70 GTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQP 129
Query: 165 ATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVE-------VKSLKWALISQCI 217
+ ++ +F R+R + Q+++E L L+ C
Sbjct: 130 SLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCA 189
Query: 218 INSVLSTVALLLIRTRDNVVRETAKEMPKFFELS----LLKNAAVWF-----LIFYVSCT 268
+V+ R R + + A + P E L+ A+ W L+ CT
Sbjct: 190 CGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPWVRPRRRLLDLAVCT 249
Query: 269 MLGYVVLLYSLSAFAVSLG----------YSQKQG---SIVSCMISVGGF---VFRPAVG 312
+ V Y+++ F ++LG Y++ G + + ++S+ GF V RPA G
Sbjct: 250 DRAFAV--YAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACG 307
Query: 313 HVADKYGPXXXXXXXXXXXXXXCLAMWIP------CRNLATAIAFGLLSGALMGSIWPLQ 366
+A G LA + R+ +AF + G G + LQ
Sbjct: 308 ALA---GLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQ 364
Query: 367 TSIISRIGGLNKLPA 381
++ G + P+
Sbjct: 365 FEVLMAAVGAPRFPS 379
>7292012 [G] KOG2504 Monocarboxylate transporter
Length = 816
Score = 57.0 bits (136), Expect = 6e-08
Identities = 39/171 (22%), Positives = 68/171 (38%), Gaps = 10/171 (5%)
Query: 15 EKDAAFYQEEAMVNETEKYNESVDYNKIQI-------PDGGYGWVVCMCYFFLNFCTWGS 67
E+ A E++ +E + N+ D ++ + PDGGYGWV+C F N G
Sbjct: 35 EEAARLTAEQSPEDEDNQDNDEDDDDEESVYGELPPPPDGGYGWVICFASFMCNMIVDGI 94
Query: 68 NSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXXXXXPLINYFVIKTSVKTSIAVGI 127
F I+L ++ + K P+++ K + G
Sbjct: 95 AYTFGIFLEEFV---AYFHEGKGTVAWVGSLLSGVYLSAGPIVSALANKYGCRAVCIAGS 151
Query: 128 VLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIPATNIISPWFRRKRT 178
++ A +L F+T + + T G + FG I +PA + +F KR+
Sbjct: 152 IIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKRS 202
>Hs18699730 [G] KOG2504 Monocarboxylate transporter
Length = 515
Score = 55.5 bits (132), Expect = 2e-07
Identities = 72/376 (19%), Positives = 129/376 (34%), Gaps = 18/376 (4%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
P+GG+GW+V + + N +G + + LE+ K+
Sbjct: 65 PEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSLSMGM 124
Query: 105 XXX--PLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFIS 162
P+++ F + + VG + L+ +F + + ++LT G++ + G +F
Sbjct: 125 IFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAY 184
Query: 163 IPATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEVKSLKWALISQCIINSVL 222
P+ I+ +F+++ L ++ +++ L + L CI VL
Sbjct: 185 QPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVL 244
Query: 223 ----STVALLLIRTRDN---------VVRETAKEMPKFFELSLLKNAAVWFLIFYVSCTM 269
T L T+D R+ K F ++ K A + +
Sbjct: 245 FLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGIPLAL 304
Query: 270 LGYVVLLYSLSAFAVSLGYSQKQGSIVSCMISVGGFVFRPAVGHVADKY-GPXXXXXXXX 328
GY V L +K +V I V V R G +AD G
Sbjct: 305 FGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVYLQVL 364
Query: 329 XXXXXXCLAMWIP-CRNLATAIAFGLLSGALMGSIWPLQTSIISRIGGLNKLPAIYSFTW 387
++M IP C IA L+ G G + I + G + F
Sbjct: 365 SFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAIGFLL 424
Query: 388 PCIGM-MSIVSPIIGL 402
+ + M++ PI GL
Sbjct: 425 GFMSIPMTVGPPIAGL 440
>Hs4759120 [G] KOG2504 Monocarboxylate transporter
Length = 478
Score = 53.9 bits (128), Expect = 5e-07
Identities = 56/295 (18%), Positives = 110/295 (36%), Gaps = 26/295 (8%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
PDGG+GW+V F ++ ++ + E + T +
Sbjct: 14 PDGGWGWIVVGAAFISIGFSYAFPKAVTVF---FKEIQQIFHTTYSEIAWISSIMLAVMY 70
Query: 105 XXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIP 164
P+ + V K + + G +L ++L +F++ + Q++LT G + GLAF P
Sbjct: 71 AGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQP 130
Query: 165 ATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEVKSLKWA-------LISQCI 217
A II +F RKR Q + K + L++ C+
Sbjct: 131 ALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACV 190
Query: 218 INSVL---------STVALLLIRTRDN-------VVRETAKEMPKFFELSLLKNAAVWFL 261
S++ S +T D+ + T +++ K+ + SL K+
Sbjct: 191 AGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIY 250
Query: 262 IFYVSCTMLGYVVLLYSLSAFAVSLGYSQKQGSIVSCMISVGGFVFRPAVGHVAD 316
+ LG+ + L+ +A G + + + +++ RP+VG +A+
Sbjct: 251 LSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIAN 305
>CE04864 [G] KOG2504 Monocarboxylate transporter
Length = 556
Score = 53.5 bits (127), Expect = 7e-07
Identities = 36/135 (26%), Positives = 58/135 (42%), Gaps = 5/135 (3%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLS-YYLESNRFPGATKLDXXXXXXXXXXXX 103
PDGG+GWVV + FF++ G F I +E N T L
Sbjct: 15 PDGGWGWVVVIGSFFIHVFADGFVYSFGILAEKLMIEFNSNNTMTSLIVSMLTGFTLGAG 74
Query: 104 XXXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISI 163
+ N + + + T I G+ G LL FAT++W ++ G+++ G +
Sbjct: 75 PLASAVCNKYGCR--ITTIIGAGVAFVGC--LLSCFATEIWHFVISVGVIMGIGFGLVYC 130
Query: 164 PATNIISPWFRRKRT 178
PA I++ +F KR+
Sbjct: 131 PAIVIVTMYFESKRS 145
>7295764 [G] KOG2504 Monocarboxylate transporter
Length = 1131
Score = 53.5 bits (127), Expect = 7e-07
Identities = 47/267 (17%), Positives = 100/267 (36%), Gaps = 28/267 (10%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
PDGG+GW++C F ++ T G + + Y ++ +L
Sbjct: 411 PDGGWGWIICGVSFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIELLGALSWSVSMVATS 470
Query: 105 XXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIP 164
L K S++ VG ++ +L +FAT+ QV + G++ G+A +
Sbjct: 471 FVVSLCR----KRSIRLLSIVGGLVMPLGILFTSFATEFGQVVFSYGIVFGVGVAMVREA 526
Query: 165 ATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEVKSLKWALISQCIINSVLST 224
+T ++ +F+R+R F++ ++ V + L + ++
Sbjct: 527 STVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVILKEGVGKAGWRLGLQIVAALTALSFF 586
Query: 225 VALLL----------------------IRTRDNVVRETAKEMPKFF--ELSLLKNAAVWF 260
+ L+ +R + ++ + + PK+F ++S LK+ V
Sbjct: 587 MGLMYRPASLYHPQRRAIQHLKNQRKKMREKKPILSQDVESTPKYFFLDISSLKSVTVKI 646
Query: 261 LIFYVSCTMLGYVVLLYSLSAFAVSLG 287
L+ S G ++ ++ A G
Sbjct: 647 LLMTSSVASFGIYTPMFLMALNAAEQG 673
>Hs4759118 [G] KOG2504 Monocarboxylate transporter
Length = 523
Score = 52.8 bits (125), Expect = 1e-06
Identities = 30/171 (17%), Positives = 71/171 (40%), Gaps = 3/171 (1%)
Query: 43 QIPDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXX 102
++PDGG+GW V + +FF+ T+G F ++ + ++S +
Sbjct: 17 EVPDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSF---NESNSRISWIISICVFV 73
Query: 103 XXXXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFIS 162
PL + + + +G +L ++ +F+ ++ +++ G++ G F
Sbjct: 74 LTFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSF 133
Query: 163 IPATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRIVEVKSLKWALI 213
+P I+S +F ++R+ F A+ + E +++L+
Sbjct: 134 LPTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLL 184
>7290288 [G] KOG2504 Monocarboxylate transporter
Length = 715
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/135 (24%), Positives = 57/135 (41%), Gaps = 5/135 (3%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLE-SNRFPGATKLDXXXXXXXXXXXX 103
PDGG+GWVV F ++ T G F I+ + +L+ N G T
Sbjct: 118 PDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYT----AWIASIMVGVT 173
Query: 104 XXXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISI 163
P+ + FV + + G +L + +++ FA + + +T G G I +
Sbjct: 174 FSSGPISSSFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLIITIGFGTGLGFGLIYL 233
Query: 164 PATNIISPWFRRKRT 178
PA ++ +F KR+
Sbjct: 234 PAIVSVTQYFEAKRS 248
>Hs5730045 [G] KOG2504 Monocarboxylate transporter
Length = 613
Score = 52.0 bits (123), Expect = 2e-06
Identities = 68/379 (17%), Positives = 131/379 (33%), Gaps = 15/379 (3%)
Query: 43 QIPDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPG-ATKLDXXXXXXXXXX 101
Q P+GG+GWVV + N +G ++ I S LE + +
Sbjct: 167 QPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMG 226
Query: 102 XXXXXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFI 161
P+++ F + + + G + L +F + L + T G+L G +F
Sbjct: 227 MIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFA 286
Query: 162 SIPATNIISPWFRRKRTXXXXXXXXXXXXXXXXFNLAMQRI---VEVKSLKWALISQCII 218
P+ I+ +F+R+ F ++ + +++ L + +
Sbjct: 287 FQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFV 346
Query: 219 NSVLS-TVALLLIRTRDNVVRETAK--------EMPKFFELSLLKNAAVWFLIFYVSCTM 269
+LS T LL ++D + + ++ K+F + + + F ++
Sbjct: 347 LMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAA 406
Query: 270 LGYVVLLYSLSAFAVSLGYSQKQGSIVSCMISVGGFVFRPAVGHVADKY-GPXXXXXXXX 328
LGY V L + K+ ++ I + R GH++D G
Sbjct: 407 LGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVL 466
Query: 329 XXXXXXCLAMWIP-CRNLATAIAFGLLSGALMGSIWPLQTSIISRIGGLNKLPAIYSFTW 387
++M IP CR+ I L G G + I + G + +
Sbjct: 467 SFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLL 526
Query: 388 PCIGMMSIVSPIIGLRLRS 406
+ + I P I LR+
Sbjct: 527 GMMALPMIAGPPIAGLLRN 545
>CE29573 [G] KOG2504 Monocarboxylate transporter
Length = 594
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/134 (23%), Positives = 55/134 (40%), Gaps = 3/134 (2%)
Query: 45 PDGGYGWVVCMCYFFLNFCTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXX 104
PDGG+GWVV + FF++ G F + + +E A+
Sbjct: 18 PDGGWGWVVVLGSFFVHVFADGFVYSFGVLVETLMEEFH---ASNTMAALIISLLTGLTL 74
Query: 105 XXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIP 164
PL + K + + G + L FAT +W + +T G+++ G + P
Sbjct: 75 GSGPLASAVCNKYGCRITTITGAGVAFVGCALSYFATAMWHIVITVGVIMGTGFGLMYCP 134
Query: 165 ATNIISPWFRRKRT 178
A I++ +F KR+
Sbjct: 135 AIVIVTMYFENKRS 148
>CE02803 [G] KOG2504 Monocarboxylate transporter
Length = 808
Score = 52.0 bits (123), Expect = 2e-06
Identities = 36/175 (20%), Positives = 73/175 (41%), Gaps = 9/175 (5%)
Query: 9 SDQKSREKDAAFYQEEAMVNETEKYNESVDYNKI------QIPDGGYGWVVCMCYFFLNF 62
S+ + ++D + + N + +Y+ ++ ++ Q PDGGYGWV+ F N
Sbjct: 42 SNFEEDDQDIGSLNDGQLTNYSSQYSINMGVQQVEPLLVPQAPDGGYGWVIVFAAFMSNL 101
Query: 63 CTWGSNSGFAIYLSYYLESNRFPGATKLDXXXXXXXXXXXXXXXXPLINYFVIKTSVKTS 122
G ++ F+ + Y E R+ + L PL++ K +
Sbjct: 102 VVDGISTAFSEFKQSYKE--RYQESDGL-TVFIGSLIIGTYLLVGPLVSALCNKYEQRYV 158
Query: 123 IAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFISIPATNIISPWFRRKR 177
+ G ++ G A ++ + ++ L G++ G I +PA ++ +F KR
Sbjct: 159 VMAGGLISGIAFMIAPASPNIYVFMLIYGVMGGLGFGMIYLPAIVVVGFYFDSKR 213
>7303008 [G] KOG2504 Monocarboxylate transporter
Length = 471
Score = 50.8 bits (120), Expect = 4e-06
Identities = 36/135 (26%), Positives = 49/135 (35%), Gaps = 5/135 (3%)
Query: 44 IPDGGYGWVVCMCYFFLNFCTWGSNSGFA-IYLSYYLESNRFPGATKLDXXXXXXXXXXX 102
+PDGGYGW+V +N S F +++ + L
Sbjct: 9 VPDGGYGWIVVAAVALINMTNQSILSVFGQLFVGELQKMQEDTFTAALITNLNSLALNFS 68
Query: 103 XXXXXPLINYFVIKTSVKTSIAVGIVLQGAALLLCAFATKLWQVFLTQGLLVSFGLAFIS 162
P I F + A G +L L LCAFA++ W L V FGL IS
Sbjct: 69 GLFIGPAIKSF----KPRNVAATGCILVALGLALCAFASESWHFILGYSFFVGFGLGLIS 124
Query: 163 IPATNIISPWFRRKR 177
I+ +F KR
Sbjct: 125 PSTFMAINSYFTTKR 139
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.326 0.140 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,742,483
Number of Sequences: 60738
Number of extensions: 860976
Number of successful extensions: 2820
Number of sequences better than 1.0e-05: 17
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 2791
Number of HSP's gapped (non-prelim): 24
length of query: 482
length of database: 30,389,216
effective HSP length: 110
effective length of query: 372
effective length of database: 23,708,036
effective search space: 8819389392
effective search space used: 8819389392
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)