ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4454 good L KOG0217 Replication, recombination and repair Mismatch repair ATPase MSH6 (MutS family)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4454 1575699 1572118 -1194
(1194 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR097c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 1321 0.0
SPCC285.16c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 723 0.0
At4g02070 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 447 e-125
Hs4504191 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 427 e-119
CE28985 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 421 e-117
ECU10g0710 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 367 e-101
Hs4505249 [L] KOG0218 Mismatch repair MSH3 303 1e-81
SPAC8F11.03 [L] KOG0218 Mismatch repair MSH3 293 1e-78
7294307 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 259 1e-68
YCR092c [L] KOG0218 Mismatch repair MSH3 219 2e-56
Hs4557761 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 219 2e-56
YOL090w [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 206 2e-52
CE21000 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 204 5e-52
SPBC24C6.12c [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 182 3e-45
7298155 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 167 1e-40
At4g25540 [L] KOG0218 Mismatch repair MSH3 162 2e-39
CE24714 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 139 3e-32
Hs4505253 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 137 1e-31
Hs21361940 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 132 3e-30
At4g17380 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 126 2e-28
CE26678 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 123 2e-27
ECU03g0540 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family) 121 6e-27
YFL003c [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 118 6e-26
YDL154w [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 118 6e-26
Hs4505251 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 117 1e-25
Hs20535615 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family) 117 1e-25
At3g24320 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family) 99 4e-20
At3g20475 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family) 76 4e-13
>YDR097c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1242
Score = 1321 bits (3420), Expect = 0.0
Identities = 638/993 (64%), Positives = 795/993 (79%), Gaps = 14/993 (1%)
Query: 210 AYNPNRSLPATPKSQGKHTKFNKTNGERYQWLVHERDAEGRDKSDPDYDPRTLYIPGDAW 269
+YNP+ S P+ + K +KFNK N ERYQWLV ERDA+ R KSDP+YDPRTLYIP AW
Sbjct: 252 SYNPSHSQPS---ATSKSSKFNKQNEERYQWLVDERDAQRRPKSDPEYDPRTLYIPSSAW 308
Query: 270 SKFTPFEKQYWEIKSKMWDCILFFKKGKFFELYEKDAHLGHHLFDLKIAGGGRANMQLAG 329
+KFTPFEKQYWEIKSKMWDCI+FFKKGKFFELYEKDA L + LFDLKIAGGGRANMQLAG
Sbjct: 309 NKFTPFEKQYWEIKSKMWDCIVFFKKGKFFELYEKDALLANALFDLKIAGGGRANMQLAG 368
Query: 330 VPEMSFDYWASQFIQYGYKVAKVDQKESMLAKEMREGSKGIVERELQCVLTSGTLTDSEM 389
+PEMSF+YWA+QFIQ GYKVAKVDQ+ESMLAKEMREGSKGIV+RELQC+LTSGTLTD +M
Sbjct: 369 IPEMSFEYWAAQFIQMGYKVAKVDQRESMLAKEMREGSKGIVKRELQCILTSGTLTDGDM 428
Query: 390 LKSDLATYCVAVREEPITYYDE-----EILALPKTGKYFGFAAIDTATGHIDLLEFEDDE 444
L SDLAT+C+A+REEP +Y+E + K FG A IDTATG + +LEFEDD
Sbjct: 429 LHSDLATFCLAIREEPGNFYNETQLDSSTIVQKLNTKIFGAAFIDTATGELQMLEFEDDS 488
Query: 445 ECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPEAIINQ-RTSKEFYDFEKTFDE 503
EC++LDT+MSQ +P EV+ME++N+ +LA KI+KFN+ P AI N+ + +EFYD +KT+ E
Sbjct: 489 ECTKLDTLMSQVRPMEVVMERNNLSTLANKIVKFNSAPNAIFNEVKAGEEFYDCDKTYAE 548
Query: 504 LITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGGLLSYLQWLKLDTSLVTMGQVEEYNPV 563
+I+ EYF + + WP VLKSYY+TGKKVGF AFGGLL YL+WLKLD +L++M ++EY+ V
Sbjct: 549 IISSEYFSTEEDWPEVLKSYYDTGKKVGFSAFGGLLYYLKWLKLDKNLISMKNIKEYDFV 608
Query: 564 RSQTCLALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKRKLRKWVMHPLLKIED 623
+SQ + LDGITLQNLEIF+N++DG+D+G+LFKL NRAITPMGKR ++KW+MHPLL+ D
Sbjct: 609 KSQHSMVLDGITLQNLEIFSNSFDGSDKGTLFKLFNRAITPMGKRMMKKWLMHPLLRKND 668
Query: 624 INXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMLSRVHSCSLKIQYFNKVLCGFEDILA 683
I RML+R+HS ++K++ F KV+ FE I+
Sbjct: 669 IESRLDSVDSLLQDITLREQLEITFSKLPDLERMLARIHSRTIKVKDFEKVITAFETIIE 728
Query: 684 LVEKLSIFADLKGSLKSYLTEIPSSLTTVLEAWSNAFDRNLAVKDGVIVPNRGVEPEFDE 743
L + L DLKG + Y++ P L +++W+NAF+R A+ + +IVP RG + EFD+
Sbjct: 729 LQDSLKN-NDLKGDVSKYISSFPEGLVEAVKSWTNAFERQKAINENIIVPQRGFDIEFDK 787
Query: 744 SMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQMAAN 803
SMDRIQ +ED+L E L Y+K K SNIQ+KDSGKEIYTIE+P++AT+NVP W QMAAN
Sbjct: 788 SMDRIQELEDELMEILMTYRKQFKCSNIQYKDSGKEIYTIEIPISATKNVPSNWVQMAAN 847
Query: 804 KSFKRYYSADVQRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAISNIDC 863
K++KRYYS +V+ LAR MAEA+E+HK LE+DLKNRL +KF HYN +W+PTIQAISNIDC
Sbjct: 848 KTYKRYYSDEVRALARSMAEAKEIHKTLEEDLKNRLCQKFDAHYNTIWMPTIQAISNIDC 907
Query: 864 IISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAKEFIPND 923
++++ RTSE LG P+CRP +V+ + +TN +LNG+++FK LRHPCFN+G+++AK+FIPND
Sbjct: 908 LLAITRTSEYLGAPSCRPTIVDEVDSKTNTQLNGFLKFKSLRHPCFNLGATTAKDFIPND 967
Query: 924 VVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGA 983
+ LGK+ P+LGLLTGANAAGKST+LRM C+AVI+AQ+GCY+PCE A TP+DRIMTRLGA
Sbjct: 968 IELGKEQPRLGLLTGANAAGKSTILRMACIAVIMAQMGCYVPCESAVLTPIDRIMTRLGA 1027
Query: 984 SDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHI 1043
+DNIMQGKSTFFVEL+ETKKILD+ TNRSLLVVDELGRGGSSSDGFAIAE+VLHHVATHI
Sbjct: 1028 NDNIMQGKSTFFVELAETKKILDMATNRSLLVVDELGRGGSSSDGFAIAESVLHHVATHI 1087
Query: 1044 QSLGFFATHYAALGSSFTNHPNVQPLKMAILVDEESRNVTFLYKLVDGKSDGSFGMHVAS 1103
QSLGFFATHY L SSF +HP V+PLKM+ILVDE +RNVTFLYK+++G+S+GSFGMHVAS
Sbjct: 1088 QSLGFFATHYGTLASSFKHHPQVRPLKMSILVDEATRNVTFLYKMLEGQSEGSFGMHVAS 1147
Query: 1104 MCGIPRSVVDNASIAAENLEHTSKLIKER----KNLHQSINPVPLGLQSDVVRLVYGDGL 1159
MCGI + ++DNA IAA+NLEHTS+L+KER NL+ + VP GLQSD VR+ YGDGL
Sbjct: 1148 MCGISKEIIDNAQIAADNLEHTSRLVKERDLAANNLNGEVVSVPGGLQSDFVRIAYGDGL 1207
Query: 1160 TNSKGGTGEGVRVYDNNIKSNVLKSFISVIDGL 1192
N+K G+GEGV YD NIK NVLKS S+ID L
Sbjct: 1208 KNTKLGSGEGVLNYDWNIKRNVLKSLFSIIDDL 1240
>SPCC285.16c [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1254
Score = 723 bits (1866), Expect = 0.0
Identities = 393/928 (42%), Positives = 568/928 (60%), Gaps = 34/928 (3%)
Query: 208 PLAYNPNRSLPATPKSQGKHTKFNKTNGERYQWLVHERDAEGRDKSDPDYDPRTLYIPGD 267
P N N L K + + F K N ERY+WL+ RDA+ DP+YDPRTLYIP
Sbjct: 310 PTKSNKNGVLNREEKRRQRMEAFKKENNERYEWLLDVRDADQNRVGDPNYDPRTLYIPPS 369
Query: 268 AWSKFTPFEKQYWEIKSKMWDCILFFKKGKFFELYEKDAHLGHHLFDLKIAGGGRANMQL 327
AW+ F PFEKQ+W+IK + D ++FF+KGKF+ELYE DA +GH +F LK+ R NM++
Sbjct: 370 AWATFKPFEKQFWKIKKDLMDTVVFFQKGKFYELYENDAAIGHQVFSLKLTD--RVNMKM 427
Query: 328 AGVPEMSFDYWASQFIQYGYKVAKVDQKESMLAKEMREGSKG-----IVERELQCVLTSG 382
G+PE SFDYWASQFI GY++A+VDQ E+ L KE+++ + +V+R L VLTSG
Sbjct: 428 VGIPEASFDYWASQFIAKGYRIARVDQLETALGKEIKDRQRTQKEEKVVQRGLTQVLTSG 487
Query: 383 TLTDSEMLKSDLATYCVAVREEPITYYDEEILALPKTGKYFGFAAIDTATGHIDLLEFED 442
TL D ML SDL+TYC+A++E + +E FG IDT+TG + EF D
Sbjct: 488 TLVDEAMLTSDLSTYCMAIKESLQSDNEEPS---------FGICFIDTSTGGFHMCEFTD 538
Query: 443 DEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPEAIINQ-RTSKEFYDFEKTF 501
D ++LDT+++Q +P E+I+EKS + + + IK+ +I N + EF+D E+
Sbjct: 539 DIHRTKLDTLLTQVRPKELILEKSKISQKSIRAIKYCVSSSSIWNFIKPYTEFWDNERVE 598
Query: 502 DELITHEYFKS-MDRWPTVLKSYYETGKKVGFHAFGGLLSYLQWLKLDTSLVTMGQVEEY 560
E+I +YFK+ ++ P +LKSY K + AFG L YL+ LKLD + +MG +EY
Sbjct: 599 REIIAGDYFKNGLEGAPKILKSYLSE-KPLAISAFGALFWYLRQLKLDKDMCSMGNFDEY 657
Query: 561 NPVRSQTCLALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKRKLRKWVMHPLLK 620
+ + T L ++G TL+NLEIF+N++DG G+LF L+ R +TP GKR W+ HPL
Sbjct: 658 DASQQSTSLLMNGQTLKNLEIFSNSFDGGSEGTLFHLLCRCVTPFGKRLFHTWLCHPLRS 717
Query: 621 IEDINXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMLSRVHSCSLKIQYFNKVLCGFED 680
IN R++SRVH+ K F +VL GF+
Sbjct: 718 GTAINARLDVVELIADNPVIRDTIWGFLHKLPDLERLISRVHAGRSKPADFVRVLEGFQR 777
Query: 681 ILALVEKL--SIFADLKGSLKSYLTEIPSSLTTVLEAWSNAFDRNLAVKDGVIVPNRGVE 738
I + ++L +G+L + + ++ LEAW+ AF+ A ++GV P G E
Sbjct: 778 INSAFDQLREEFMEVAEGTLLGEIIQSAPNMKEELEAWTRAFNWQKASEEGVFEPEIGFE 837
Query: 739 PEFDESMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWT 798
E+D S ++++L L QYKK L+ S++ FK+ GKE+Y +EVP VP W
Sbjct: 838 AEYDTSQKYQSELKNELYALLEQYKKQLRCSSLNFKNIGKEVYQVEVPSDV--KVPVNWC 895
Query: 799 QMAANKSFKRYYSADVQRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAI 858
+M+ K RYY+ ++++ +++ EA E+H + ++ + Y +F ++Y WL I+
Sbjct: 896 KMSGTKKTNRYYNDELRKKIKKLLEAEELHLAIMSRMQEKFYIRFDSNYEQ-WLALIKYT 954
Query: 859 SNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAKE 918
++IDC SL++ + +LG P CRP+++E + +G++ F+ELRHPC N +S+A
Sbjct: 955 ASIDCFFSLSQAAAALGEPYCRPEIIE--------QKDGHLYFEELRHPCIN--ASAAST 1004
Query: 919 FIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIM 978
F+PNDVVLG ++P + +LTG N AGKST+LR C+AVI+AQLGC++P + A TP+ I
Sbjct: 1005 FVPNDVVLGGESPNMIVLTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASITPMTSIY 1064
Query: 979 TRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHH 1038
TRLGA+D+IM +STF VELSETKKILD +SL+++DELGRG S+ DG AIA AVLHH
Sbjct: 1065 TRLGANDDIMSARSTFMVELSETKKILDECGPKSLVILDELGRGTSTYDGHAIAYAVLHH 1124
Query: 1039 VATHIQSLGFFATHYAALGSSFTNHPNVQPLKMAILVDEESRNVTFLYKLVDGKSDGSFG 1098
+ ++I LGFF+THY +L F +H V+ ++MA VDE+ R VTFLYKL DG S+G
Sbjct: 1125 LVSNIGCLGFFSTHYQSLCVDFMHHRQVRLMQMAAAVDEKIRRVTFLYKLEDGICPKSYG 1184
Query: 1099 MHVASMCGIPRSVVDNASIAAENLEHTS 1126
M+VASM G+P V+D A A LE S
Sbjct: 1185 MNVASMAGLPEKVIDAAEEKASELEQAS 1212
>At4g02070 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1324
Score = 447 bits (1149), Expect = e-125
Identities = 304/956 (31%), Positives = 479/956 (49%), Gaps = 80/956 (8%)
Query: 229 KFNKTNGERYQWL-VHERDAEGRDKSDPDYDPRTLYIPGDAWSKFTPFEKQYWEIKSKMW 287
+F + E++++L V RDA+ R +D +YDPRTLY+P D K T ++Q+WE K+K
Sbjct: 335 RFGARDSEKFRFLGVDRRDAKRRRPTDENYDPRTLYLPPDFVKKLTGGQRQWWEFKAKHM 394
Query: 288 DCILFFKKGKFFELYEKDAHLGHHLFDLKIAGGGRANMQLAGVPEMSFDYWASQFIQYGY 347
D ++FFK GKF+EL+E DAH+G D++ G + + G PE +F + ++ GY
Sbjct: 395 DKVVFFKMGKFYELFEMDAHVGAKELDIQYMKGEQPH---CGFPEKNFSVNIEKLVRKGY 451
Query: 348 KVAKVDQKESMLAKEMREGSKG----IVERELQCVLTSGTLTDSEMLKSDL-ATYCVAVR 402
+V V+Q E+ E R G +V+RE+ V+T GTLTD EML ++ A+Y +A+
Sbjct: 452 RVLVVEQTETPDQLEQRRKETGSKDKVVKREVCAVVTKGTLTDGEMLLTNPDASYLMALT 511
Query: 403 EEPITYYDEEILALPKTGKYFGFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVI 462
E E L P FG +D AT I L +F+DD++CS L ++S+ +P E+I
Sbjct: 512 E------GGESLTNPTAEHNFGVCLVDVATQKIILGQFKDDQDCSALSCLLSEMRPVEII 565
Query: 463 MEKSNVCSLAQKIIKFNAQPEAIINQRTSKEFYDFEKTFDELITHEYFKSMDRWPTVLKS 522
+ ++ I + + N EF+D EKT E+ +K ++ P+ +
Sbjct: 566 KPAKVLSYATERTIVRQTRNPLVNNLVPLSEFWDSEKTIYEVGI--IYKRINCQPS--SA 621
Query: 523 YYETGKKVG-----------------------FHAFGGLLSYLQWLKLDTSLVTMGQVE- 558
Y GK +G A GG + YL+ LD SL+ + E
Sbjct: 622 YSSEGKILGDGSSFLPKMLSELATEDKNGSLALSALGGAIYYLRQAFLDESLLRFAKFES 681
Query: 559 ----EYNPVRSQTCLALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKRKLRKWV 614
+++ V + + LD L+NLEIF N+ +G G+L+ +N+ IT GKR L+ W+
Sbjct: 682 LPYCDFSNVNEKQHMVLDAAALENLEIFENSRNGGYSGTLYAQLNQCITASGKRLLKTWL 741
Query: 615 MHPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXRMLSRVHS---------- 663
PL E I R+++R+ S
Sbjct: 742 ARPLYNTELIKERQDAVAILRGENLPYSLEFRKSLSRLPDMERLIARMFSSIEASGRNGD 801
Query: 664 --------CSLKIQYFNKVLCGFEDILALVEKLSIFA--DLKGSLKSYLTEIPS--SLTT 711
++Q F L G E + L D L LT S ++++
Sbjct: 802 KVVLYEDTAKKQVQEFISTLRGCETMAEACSSLRAILKHDTSRRLLHLLTPGQSLPNISS 861
Query: 712 VLEAWSNAFDRNLAVKDGVIVPNRGVEPEFDESMDRIQGIEDQLQECLTQYKKLLKSSNI 771
++ + +AFD A G ++P+ G + E+D + ++ E L++ L + +KLL ++I
Sbjct: 862 SIKYFKDAFDWVEAHNSGRVIPHEGADEEYDCACKTVEEFESSLKKHLKEQRKLLGDASI 921
Query: 772 QFKDSGKEIYTIEVPMAATRNVPHEWTQMAANKSFKRYYSADVQRLARQMAEAREMHKVL 831
+ GK+ Y +EVP + + +VPH++ ++ K RY++ +++L +++++A+ +
Sbjct: 922 NYVTVGKDEYLLEVPESLSGSVPHDYELCSSKKGVSRYWTPTIKKLLKELSQAKSEKESA 981
Query: 832 EDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPET 891
+ RL +F H W + A + +D +ISLA S+S CRP ++ G +
Sbjct: 982 LKSISQRLIGRFCEHQEK-WRQLVSATAELDVLISLAFASDSYEGVRCRP-VISGSTSDG 1039
Query: 892 NEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLG-KDAPQLGLLTGANAAGKSTVLRM 950
L+ L HP S F+PN+V +G + LLTG N GKST+LR
Sbjct: 1040 VPHLSA----TGLGHPVLRGDSLGRGSFVPNNVKIGGAEKASFILLTGPNMGGKSTLLRQ 1095
Query: 951 TCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTN 1010
C+AVILAQ+G +P E E +PVD+I R+GA D+IM G+STF ELSET +L T
Sbjct: 1096 VCLAVILAQIGADVPAETFEVSPVDKICVRMGAKDHIMAGQSTFLTELSETAVMLTSATR 1155
Query: 1011 RSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPNVQPLK 1070
SL+V+DELGRG ++SDG AIAE+VL H +Q GFF+THY L + +P V
Sbjct: 1156 NSLVVLDELGRGTATSDGQAIAESVLEHFIEKVQCRGFFSTHYHRLSVDYQTNPKVSLCH 1215
Query: 1071 MAILVDE---ESRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLE 1123
MA + E VTFLY+L G S+G++VA + G+P V+ A I ++ E
Sbjct: 1216 MACQIGEGIGGVEEVTFLYRLTPGACPKSYGVNVARLAGLPDYVLQRAVIKSQEFE 1271
>Hs4504191 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1360
Score = 427 bits (1099), Expect = e-119
Identities = 296/987 (29%), Positives = 463/987 (45%), Gaps = 115/987 (11%)
Query: 236 ERYQWLVHE--RDAEGRDKSDPDYDPRTLYIPGDAWSKFTPFEKQYWEIKSKMWDCILFF 293
E +WL E RD R PD+D TLY+P D + TP +++W+IKS+ +D ++ +
Sbjct: 368 ETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTPGMRKWWQIKSQNFDLVICY 427
Query: 294 KKGKFFELYEKDAHLGHHLFDLKIAGGGRANMQLAGVPEMSFDYWASQFIQYGYKVAKVD 353
K GKF+ELY DA +G L G A+ +G PE++F ++ +Q GYKVA+V+
Sbjct: 428 KVGKFYELYHMDALIGVSELGLVFMKGNWAH---SGFPEIAFGRYSDSLVQKGYKVARVE 484
Query: 354 QKES-----MLAKEMREGSK--GIVERELQCVLTSGTLTDSEMLKSDLATYCVAVREEPI 406
Q E+ ++M SK +V RE+ ++T GT T S + +P
Sbjct: 485 QTETPEMMEARCRKMAHISKYDRVVRREICRIITKGTQTYS------------VLEGDPS 532
Query: 407 TYYDEEILALPKTG-------KYFGFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPT 459
Y + +L+L + + +G +DT+ G + +F DD CS+ T+++ + P
Sbjct: 533 ENYSKYLLSLKEKEEDSSGHTRAYGVCFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPV 592
Query: 460 EVIMEKSNVCSLAQKIIKFNAQPEAIINQRTSKEFYDFEKTFDELITHEYFKSM------ 513
+V+ EK N+ + I+K + +F+D KT L+ EYF+
Sbjct: 593 QVLFEKGNLSKETKTILKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIG 652
Query: 514 DRWPTVLKSYYETGKKVGF----------HAFGGLLSYLQWLKLDTSLVTMGQVEEYNPV 563
P VLK +G A GG + YL+ +D L++M EEY P+
Sbjct: 653 VMLPQVLKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEEYIPL 712
Query: 564 RSQTC---------------LALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKR 608
S T + LD +TL NLEIF N +G+ G+L + ++ TP GKR
Sbjct: 713 DSDTVSTTRSGAIFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHTPFGKR 772
Query: 609 KLRKWVMHPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMLSRVHSCS--L 666
L++W+ PL IN R+LS++H+ L
Sbjct: 773 LLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPDLERLLSKIHNVGSPL 832
Query: 667 KIQ--------------YFNKVLCGF----EDILALVEKLSIFADLKGSLKSYL------ 702
K Q Y K + F E + + + I ++ KS +
Sbjct: 833 KSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKVMCKIIGIMEEVADGFKSKILKQVIS 892
Query: 703 --TEIPSS----LTTVLEAWSNAFDRNLAVKDGVIVPNRGVEPEFDESMDRIQGIEDQLQ 756
T+ P LT L W AFD A K G+I P G + ++D+++ I+ E L
Sbjct: 893 LQTKNPEGRFPDLTVELNRWDTAFDHEKARKTGLITPKAGFDSDYDQALADIRENEQSLL 952
Query: 757 ECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMA-ATRNVPHEWTQMAANKSFKRYYSADVQ 815
E L + + + I + G+ Y +E+P TRN+P E+ + K KRY++ ++
Sbjct: 953 EYLEKQRNRIGCRTIVYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIE 1012
Query: 816 RLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTSESLG 875
+ + A E V D RL+ F +Y W ++ I+ +D ++ LA S
Sbjct: 1013 KKLANLINAEERRDVSLKDCMRRLFYNFDKNYKD-WQSAVECIAVLDVLLCLANYSRGGD 1071
Query: 876 FPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLGKDAPQLG- 934
P CRP + L PE ++ K RHPC + +FIPND+++G + +
Sbjct: 1072 GPMCRPVI---LLPEDTPP---FLELKGSRHPCITK-TFFGDDFIPNDILIGCEEEEQEN 1124
Query: 935 ------LLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIM 988
L+TG N GKST++R + ++AQ+GCY+P E TP+DR+ TRLGASD IM
Sbjct: 1125 GKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPIDRVFTRLGASDRIM 1184
Query: 989 QGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGF 1048
G+STFFVELSET IL T SL++VDELGRG ++ DG AIA AV+ +A I+
Sbjct: 1185 SGESTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTL 1244
Query: 1049 FATHYAALGSSFTNHPNVQPLKMAILVDEE-----SRNVTFLYKLVDGKSDGSFGMHVAS 1103
F+THY +L ++ + V+ MA +V+ E +TFLYK + G S+G + A
Sbjct: 1245 FSTHYHSLVEDYSQNVAVRLGHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAAR 1304
Query: 1104 MCGIPRSVVDNASIAAENLEHTSKLIK 1130
+ +P V+ A E ++ ++
Sbjct: 1305 LANLPEEVIQKGHRKAREFEKMNQSLR 1331
>CE28985 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1186
Score = 421 bits (1083), Expect = e-117
Identities = 309/995 (31%), Positives = 477/995 (47%), Gaps = 100/995 (10%)
Query: 214 NRSLPATPKSQGKHTKFNKTNGERYQWLVHERDAEGRDKSDPDYDPRTLYIPGDAWSKFT 273
N+++ P + H F+ ++ RD R SDP+YDP+TL++P D K T
Sbjct: 198 NKAVELEPAERFDHESFDFLKPDKI------RDGFKRPMSDPEYDPKTLWVPPDFHQKQT 251
Query: 274 PFEKQYWEIKSKMWDCILFFKKGKFFELYEKDAHLGHHLFDLKIAGGGRANMQLAGVPEM 333
P +Q+W +KS+ +D IL FK GKF+E Y DA ++ G A+ AG PE
Sbjct: 252 PGHRQWWTMKSQHFDTILLFKVGKFYETYHMDAVEVVRALNIAFMRGSYAH---AGFPEH 308
Query: 334 SFDYWASQFIQYGYKVAKVDQKESMLAKEMR----EGSKGIVERELQCVLTSGTLTDSEM 389
+ +A Q + +GYKVA+++Q E+ E R + + +V RE+ V ++GT T +
Sbjct: 309 AASKFADQLMNHGYKVARIEQTETPQMLEERNQKTKTKEKVVRREVCRVTSNGTRTYGVL 368
Query: 390 LKSDLATYCVAVREEPITYYDEEILAL-----PKTGKY-FGFAAIDTATGHIDLLEFEDD 443
DL + + +P + +LA+ P+TGK +G IDT T HI + +FEDD
Sbjct: 369 DGVDLGSASSTL--DPTA---KHLLAIKEFHNPETGKSSYGVCMIDTTTAHIRIGQFEDD 423
Query: 444 EECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPEAIINQRTSKEFYDFEKTFDE 503
+ SQL T+++ + I+E+ ++ S + II + + K+F E
Sbjct: 424 DYRSQLRTLLANVIVVQAIVERGSISSTTKSIINGILFSVPVEHLLPKKQFMTAEDVVRI 483
Query: 504 LITHEYFKS-MDRWPTVLKSYYE---------TGKKVGFHAFGGLLSYLQWLKLDTSLVT 553
+ +Y+ S WP VLK E T ++ AFG + YL+ +D +++
Sbjct: 484 VSNEDYYGSDASEWPEVLKGMLEDSSILPKPSTDWQLALSAFGAIFWYLRDSLIDVDMLS 543
Query: 554 MGQVEEYNPVRSQTC------------LALDGITLQNLEIFANTYDGTDRGSLFKLINRA 601
M V YN + L LDG L+NL I N D + SL+ +IN+
Sbjct: 544 MRNVTIYNSNSMENDQKKEKIDWNGKNLILDGTALENLNIVPNGRD-SHLTSLYYVINKC 602
Query: 602 ITPMGKRKLRKWVMHPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXRMLS 659
TP G+R LR W++ P + + R+L
Sbjct: 603 STPFGRRLLRSWLLQPTCDPKKLEQRQKAIKWLVSPDASSFMTTATATLKKIPDLDRLLQ 662
Query: 660 RVHSCSLKIQ----------YFNKVLCGFEDILALVEKLSIFADLKGSLKSY-------- 701
++H+ LK + +F+ + + I L+ + F K Y
Sbjct: 663 KIHTIGLKYRSEKHPDSRAIFFDTIKTNQKKIAELLAAIDGFKLCNKLRKEYIKVQKEGE 722
Query: 702 ----LTEIPSSLTTVLEAWSNA------FDRNLAVKDGVIVPNRGVEPEFDESMDRIQGI 751
L E+ + + E N FDR+ A+KDG IVPN G + E+DE+++R++
Sbjct: 723 GCELLDELLGNEQEMEEVDENIYFFEKMFDRSTAMKDGKIVPNAGCDEEYDEALNRVKEA 782
Query: 752 EDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQMAANKSFKRYYS 811
++L + K S +I+F DSGK Y +E+P V + + K F RY +
Sbjct: 783 LNELNDYKDSVAKKY-SCSIKFVDSGKVKYLLEMP--ENTKVSSSFELKSRRKGFIRYST 839
Query: 812 ADVQRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTS 871
D ++L + + L DD R++++F H N +WL T++ +S+ D + SLA +
Sbjct: 840 PDSEQLVAALDAVEKEKSKLGDDATRRVFEQF-GHKNPIWLETVKLVSSFDVLTSLALFA 898
Query: 872 ESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGS----SSAKEFIPNDVVLG 927
+S F C P+ + Y+ + HPC + S + FI N +G
Sbjct: 899 KSSPFEMCMPEF-------DFNATDPYLIVDKGVHPCLALQSRNEVTQTTSFIANSTTMG 951
Query: 928 KDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNI 987
+ LLTG N GKST++R T V ILA +G +P TP+DRI TR+GA+D I
Sbjct: 952 ASEAAVMLLTGPNMGGKSTLMRQTAVLAILAHIGSMVPAFSMRLTPIDRIFTRIGANDRI 1011
Query: 988 MQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLG 1047
M G+STFF+EL ET +L T SLL+VDELGRG S+ DG AIA AVL ++ +
Sbjct: 1012 MCGESTFFIELKETDIMLKNATKHSLLLVDELGRGTSTFDGTAIASAVLQKISDDLACRT 1071
Query: 1048 FFATHYAALGSSFTNHPNVQPLKMAILVDEES------RNVTFLYKLVDGKSDGSFGMHV 1101
FF+THY ++ SFTNHPNV+ M +VD+E+ +VTFLY+L G S+G +
Sbjct: 1072 FFSTHYHSICDSFTNHPNVRLAHMKCVVDKENNEDPTMEDVTFLYELESGICPKSYGFYA 1131
Query: 1102 ASMCGIPRSVVDNASIAAENLEHTSKLIKERKNLH 1136
A + GI VV NA + E+ + S LI + K H
Sbjct: 1132 AKLAGIDHQVVRNAYL--ESNKFASNLIIDPKIRH 1164
>ECU10g0710 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 922
Score = 367 bits (942), Expect = e-101
Identities = 276/901 (30%), Positives = 423/901 (46%), Gaps = 114/901 (12%)
Query: 236 ERYQWLVHERDAEGRDKSDPDYDPRTLYIPGDAWSKFTPFEKQYWEIKSKMWDCILFFKK 295
ERY++L RD GR + D YDP TL IP + KFTPFEKQ+W+IK +D I+FFKK
Sbjct: 100 ERYRFLEDVRDRNGRRRGDEGYDPSTLLIPEHEYKKFTPFEKQFWDIKKDFFDTIVFFKK 159
Query: 296 GKFFELYEKDAHLGHHLFDLKIAGGGRANMQLAGVPEMSFDYWASQFIQYGYKVAKVDQK 355
GKF+ELYE DA +G LFDLKI R NM+++G PE S DYW+ +F+++GYK+A+V+Q
Sbjct: 160 GKFYELYENDALVGARLFDLKIT--DRVNMKMSGFPEGSLDYWSRKFLEHGYKIARVEQS 217
Query: 356 ESMLAKEMREGSK----------GIVERELQCVLTSGTLTDSEMLKSDLATYCVAVREEP 405
E+M+ K++RE + I+ REL+ ++T GT+ + ++S + Y ++V +
Sbjct: 218 ENMIGKQIRERDEMSKEGRVVKDKIIRRELKEIITQGTIYSIDYMRSAMPMYLMSVATDE 277
Query: 406 ITYYDEEILALPKTGK-YFGFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIME 464
+ Y + +G+ + D + G + F DD + TI+SQ E+I +
Sbjct: 278 VCYSE------TCSGEVHTSVVLYDASIGEVYFSSFCDDRSHHGIRTILSQHDVKEMIAD 331
Query: 465 KSNVCSLAQKIIKFNAQPEAIINQRTSKEFYDFEKTFDELITHEYFKSMDRWPTVLKSYY 524
S P + D+ V Y
Sbjct: 332 FS-----------IGGVPRVV---------------------------PDKTACVSNRKY 353
Query: 525 ETGKKVGFHAFGGLLSYLQWLKLDTSLVTMGQVEEYNPVRSQTCLALDGITLQNLEIFAN 584
E + + F L+ Y++ L+ +L+ + + R+ + +D TL+N+EIF N
Sbjct: 354 EFSNEREYVCFQYLMRYMEKLRRADALMNVKISRLQDEART---MGIDDATLRNMEIFKN 410
Query: 585 TYDGTDRGSLFKLINRAITPMGKRKLRKWVMHPLLKIEDINXXXXXXXXXXXXXXXXXXX 644
Y+GTD +LFK ++ TP G+R LR+W+M PL++ EDI
Sbjct: 411 NYNGTDEKTLFKAVDFCSTPFGQRLLRRWMMAPLVRKEDI--VKRQEMALVFKRMDSTKL 468
Query: 645 XXXXXXXXXXXRMLSRVHSCSLKIQYFNKVLCGFEDILALVEKLSIFADLKGSLKSYLTE 704
R+L R+++ + + +K I L F L L++ E
Sbjct: 469 KEALGRIGDGERLLVRLYNGNPTAKDLSKF------IRCLGACKETFDVLGMELRTRRLE 522
Query: 705 IPSSLTTVLEAWSNAFDRNLA-------VKDGVIVPNRGVEPEFDESMDRIQGIEDQLQE 757
+ E +S + L V + I P E E M IE L
Sbjct: 523 GARDIVEKAEDYSCRIEEVLVWHRKVYDVTEAGISPGEENEDELCHLMSEKGKIEGDLDA 582
Query: 758 CLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQMAANKSFKRYYSADVQRL 817
L + K L +I+F+D GK+++ +EVP VP ++ M++ K RYYS D+++L
Sbjct: 583 YLQEQKTRLGCPSIRFRDVGKDVFQMEVPKEI--GVPSDYFIMSSVKGVNRYYSRDLRKL 640
Query: 818 ARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTSE--SLG 875
+ E E + L R H + ++ IDC +S A S+
Sbjct: 641 VERYMECEERIFQSKGSLLRRAIDVLLPHV-IFFRQVFCELAQIDCYLSFATFSQRNRTS 699
Query: 876 FPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFN-MGSSSAKEFIPNDVVLGKDAPQLG 934
P KL CF+ M S F+ ND ++
Sbjct: 700 TPVFSTKL------------------------CFSGMSSPIYPAFVENDY---DGCRRIL 732
Query: 935 LLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTF 994
+LTGAN GKST+LR C VIL+Q+G + C+ E DRI TR+GA D++ +G+STF
Sbjct: 733 VLTGANMGGKSTLLRTICFNVILSQVGMDVCCKRMETPLFDRIFTRIGARDDLAKGESTF 792
Query: 995 FVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFATHYA 1054
+EL ET IL T SL+++DELGRG S+ DG IA AVL ++ + F+THY
Sbjct: 793 MIELGETSNILRHSTRDSLVIMDELGRGTSTKDGGCIARAVLEYLKKK-ECHVLFSTHYH 851
Query: 1055 ALGSSFTNHPNVQPLKMAILVDEESRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDN 1114
+ N M+ ++ + R++ FLYKLV G S S G++VA M G+P ++V+
Sbjct: 852 GIIGEVEGVSNGY---MSSVI--KGRDIVFLYKLVAGVSGDSHGLYVARMAGVPDAIVER 906
Query: 1115 A 1115
A
Sbjct: 907 A 907
>Hs4505249 [L] KOG0218 Mismatch repair MSH3
Length = 1128
Score = 303 bits (775), Expect = 1e-81
Identities = 235/892 (26%), Positives = 418/892 (46%), Gaps = 62/892 (6%)
Query: 270 SKFTPFEKQYWEIKSKMWDCILFFKKGKFFELYEKDAHLGHHLFDLKIAGGGRANMQLAG 329
S +TP E QY E+K + D +L + G + + +DA + +L I N A
Sbjct: 218 SIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAAR--ELNIYCHLDHNFMTAS 275
Query: 330 VPEMSFDYWASQFIQYGYKVAKVDQKESMLAKEMREGSKGIVERELQCVLTSGTLTDSE- 388
+P + + GYKV V Q E+ K + + + R+L + T TL +
Sbjct: 276 IPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSLFSRKLTALYTKSTLIGEDV 335
Query: 389 --MLKSDLATYCVAVREEPITYY-------DEEILALPKTGKYFGFAAIDTATGHIDLLE 439
++K D A + + T Y E + K + G + ATG +
Sbjct: 336 NPLIKLDDAVNVDEIMTDTSTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDS 395
Query: 440 FEDDEECSQLDTIMSQFKPTEVIMEKS---NVCSLAQKIIKFNAQPEAIINQRTSKEFYD 496
F+D S+L+T MS +P E+++ + +L + + Q + I +R +++
Sbjct: 396 FQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIYFE 455
Query: 497 FEKTFDELITHEYFK-SMDRWPTVLKSYYETGKKVGFHAFGGLLSYLQWLKLDTSLVTMG 555
+ F + +T Y K ++D + + S +K + ++ YL+ L+ L
Sbjct: 456 YSHAF-QAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKML---S 511
Query: 556 QVEEYNPVRSQT-CLALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKRKLRKWV 614
+ E + + S+ + ++G TL+NLEI N D +GSL +++ T G+RKL+KWV
Sbjct: 512 KPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWV 571
Query: 615 MHPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXX-XXXRMLSRVHSCSLKIQYFNK 673
PLLK+ +IN R L ++ Q F
Sbjct: 572 TQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFL 631
Query: 674 VL-------CGFEDILALVEKLSIFADLKGSLKSYLTEIPSSLTTVLEAWSNAFDRNLAV 726
++ F+ I+ V I +DL L++ + EIP L+ V ++ V
Sbjct: 632 IVKTLYHLKSEFQAIIPAVNS-HIQSDL---LRTVILEIPELLSPVEHYLKILNEQAAKV 687
Query: 727 KDGV-IVPNRGVEPEFDESMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEV 785
D + + P + D IQG+ D+++ L + +K+LK+ + Q+ + + IE+
Sbjct: 688 GDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEI 747
Query: 786 PMAATRNVPHEWTQMAANKSFKRYYSADVQRLARQMAEAREMHKVLEDDLK-NRLYKKFT 844
+A +P +W ++ + K+ R++S + R + + RE VL+ + +KF+
Sbjct: 748 KNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQ-LVLDCSAEWLDFLEKFS 806
Query: 845 NHYNAVWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKEL 904
HY+++ + ++ +DCI SLA+ ++ + CRP + E I K
Sbjct: 807 EHYHSL-CKAVHHLATVDCIFSLAKVAKQGDY--CRPTVQE----------ERKIVIKNG 853
Query: 905 RHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYI 964
RHP ++ +++PN+ L +D+ ++ ++TG N GKS+ ++ + I+AQ+G Y+
Sbjct: 854 RHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYV 913
Query: 965 PCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGS 1024
P EEA VD I TR+GA+DNI +G+STF EL++T +I+ T++SL+++DELGRG S
Sbjct: 914 PAEEATIGIVDGIFTRMGAADNIYKGRSTFMEELTDTAEIIRKATSQSLVILDELGRGTS 973
Query: 1025 SSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPN-VQPLKMAILVDEESRN-- 1081
+ DG AIA A L + ++SL F THY + N+ + V M LV E+
Sbjct: 974 THDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLD 1033
Query: 1082 ----------VTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLE 1123
VTFLY++ G + S+G++VA + +P ++ A+ ++ LE
Sbjct: 1034 PGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELE 1085
>SPAC8F11.03 [L] KOG0218 Mismatch repair MSH3
Length = 1004
Score = 293 bits (750), Expect = 1e-78
Identities = 240/910 (26%), Positives = 408/910 (44%), Gaps = 82/910 (9%)
Query: 270 SKFTPFEKQYWEIKSKMWDCILFFKKGKFFELYEKDAHLGHHLFDLKIAGGGRANMQLAG 329
S FTP E+QY E+K + IL + G F + KDA + + L I+ N A
Sbjct: 101 SVFTPLEQQYLELKKNYQETILAIEVGYKFRFFGKDAKIASEV--LGISCYFEHNFLNAS 158
Query: 330 VPEMSFDYWASQFIQYGYKVAKVDQKESMLAKEMREGSKGIVERELQCVLTSGTLTDSEM 389
VP DY + I +G KVA V Q E+ K + +R + VLT GT D
Sbjct: 159 VPSYRIDYHLERLINFGLKVAVVRQTETAALKSTSSSRNTLFDRRVARVLTKGTTLDDSF 218
Query: 390 LKSDLATYCVAVREEPITYYDEEI-LALPKTGKY-FGFAAIDTATGHIDLLEFEDDEECS 447
+ + + + I + + + K+G+ G AI ++G F+DD S
Sbjct: 219 FRFEQTQHGTLQASQFILCVADNVDKSKAKSGRVQVGLIAIQLSSGTTVYDHFQDDFLRS 278
Query: 448 QLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPEAIINQRTSKEF------------- 494
+L T +S F+P E+I K +++ A++N S E
Sbjct: 279 ELQTRLSHFQPCELIYSN-----------KLSSESVALLNHYVSTEKTCGRVVRVQHAVQ 327
Query: 495 YDFEKTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGGL-----LSYLQWLKLDT 549
D + + L K + +++ + E K + H+ + +SYL L+
Sbjct: 328 QDVKLALENLQDFFSSKCIMSGSKIIELHMEKVKSL--HSLSIICLDMAISYLMEFSLED 385
Query: 550 SLVTMGQVEEYNPVRSQTCLALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKRK 609
V Y P S + + L L+ LE+F N D T GSLF +++R T G+R
Sbjct: 386 LFVASNF---YQPFDSISSMVLSKQALEGLELFVNQTDHTPVGSLFWVLDRTYTRFGQRM 442
Query: 610 LRKWVMHPLLKIEDI-NXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMLSRVHSCSLKI 668
L++W+ PL+ E+I + LSR++
Sbjct: 443 LQRWLQKPLVDKENIIERLDAVEELAFNSNSQVQAIRKMLYRLPDLEKGLSRIYYQRCTP 502
Query: 669 QYFNKVLCGFEDILALVEKLSIFADLKGSLKSYLTEIPSSLTTVLEAWSNAFDRNLAVKD 728
VL GF + K S L+ + ++PS ++++++ + FD+ A +
Sbjct: 503 SEMFHVLKGFYKAASAFSKNSYSCFKSALLRRLIQQLPS-ISSIIDHFLGMFDQKEAENN 561
Query: 729 GVIVPNRGVE----------------PEFDESMDRIQGIEDQLQECLTQYKKLLKSSNIQ 772
+ + ++ E E I + ++ L + + L+ N++
Sbjct: 562 NKVDMFKDIDNFDLSEEPNDVDYELAQEIRELKMSILMVRTEMDFHLQELRDYLEYPNLE 621
Query: 773 FKDSGKEIYTIEVPMAATRNVPHEWTQMAANKSFKRYYSADVQRLARQMAEAREMHKVLE 832
F G + IEV + +P +W ++++ +S R+++ +Q L +++ E +
Sbjct: 622 FSIWGNVKFCIEVSKGC-KKIPPDWIKLSSTRSLFRFHTPKIQSLLIELSSHEENLTISS 680
Query: 833 DDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETN 892
+ + + + HYN + T + +DC+IS AR S G+ PE +
Sbjct: 681 EKIYRSFLSRISEHYNELRNVTT-VLGTLDCLISFARISSQSGYT----------RPEFS 729
Query: 893 EKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTC 952
+K + E RHP + S K F+PN + L D + L+TG N GKS+ ++
Sbjct: 730 DK---ELLIHESRHPMIELLSD--KSFVPNHIHLSSDGVRCLLITGPNMGGKSSFVKQLA 784
Query: 953 VAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRS 1012
++ I+AQ GC++P + A D I+ R+G+SDN+ STF VE+ ETK++L T +S
Sbjct: 785 LSAIMAQSGCFVPAKSALLPIFDSILIRMGSSDNLSVNMSTFMVEMLETKEVLSKATEKS 844
Query: 1013 LLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTN-HPNVQPLKM 1071
++++DELGRG S+ DG AI+ AVLH++ +I+S F TH+ +LG ++ M
Sbjct: 845 MVIIDELGRGTSTIDGEAISYAVLHYLNQYIKSYLLFVTHFPSLGILERRFEGQLRCFHM 904
Query: 1072 AILVDEE------SRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLEHT 1125
L +E S++++FLYKLV G + S+G++VA M GIP S++ A+ +EN E
Sbjct: 905 GYLKSKEDFETSVSQSISFLYKLVPGVASKSYGLNVARMAGIPFSILSRATEISENYE-- 962
Query: 1126 SKLIKERKNL 1135
K RKN+
Sbjct: 963 KKHRNARKNV 972
>7294307 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 985
Score = 259 bits (663), Expect = 1e-68
Identities = 222/789 (28%), Positives = 355/789 (44%), Gaps = 115/789 (14%)
Query: 245 RDAEGRDKSDPDYDPRTLYIPGDAWSKFTPFEKQYWEIKSKMWDCILFFKKGKFFELYEK 304
+D EGR PDYD TL++P + +P +Q+W +KS +DC+LFFK GKF+ELY
Sbjct: 234 KDKEGRRPDHPDYDKSTLHVPEKFLNGLSPGVRQWWVLKSDNYDCVLFFKVGKFYELYHM 293
Query: 305 DAHLGHHLFDLKIAGGGRANMQLAGVPEMSFDYWASQFIQYGYKVAKVDQKES--MLAKE 362
DA +G + G A+ +G PE+SFD ++ + G+KVA+V+Q E+ M+ +
Sbjct: 294 DADVGVNELGFTYMRGEFAH---SGFPEISFDKMSTILVDRGFKVARVEQTETPDMMTER 350
Query: 363 MR--EGSK--GIVERELQCVLTSGTLTDSEMLK---SDLATYCVAVREEPITYYDEEILA 415
+ + +K +V RE+ + GT K + Y +A+ E+ DE
Sbjct: 351 CKRIKATKFDKVVAREICQITNRGTQVFGSQCKIGPNHQPNYMLAIVEK-----DE---- 401
Query: 416 LPKTGKYFGFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKI 475
T +G IDT+ G L EFEDD+ CS+L T++S P + EKS + Q+I
Sbjct: 402 --GTCSRYGVCFIDTSIGDFHLGEFEDDKNCSRLLTLVSHHMPVLFLNEKSALSQRTQQI 459
Query: 476 IKFNAQPEAIINQ---RTSKEFYDFEKTFDELITHEYFK---SMDRWPTVLKSYY----- 524
++ I+ + K EKT +L+ Y+ S D WP VL++
Sbjct: 460 VR--TVLGGILKEPVPGNGKHACSAEKTL-KLLAERYYAGPGSDDNWPLVLRTMQSDMDH 516
Query: 525 -----ETGKKVGFHAFGGLLSYLQWLKLDTSLVTMGQVEEYNP-------------VRSQ 566
K+ A G + ++ KL+ ++ M + + Y P +
Sbjct: 517 LGLTPNDNYKLALKALGQCIFFIHKCKLEPKVLPMARYQLYVPPDQLADAKPAVASTLRR 576
Query: 567 TCLALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKRKLRKWVMHPLLKIEDINX 626
+ + LD TL NL I + SL ++ T GKR L W+ P + I
Sbjct: 577 SHMVLDATTLSNLRIIGEEH------SLLSTLDHCCTKFGKRLLHHWLCAPSCDVSVIKE 630
Query: 627 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMLSRVHSC---------------------- 664
R L+++H
Sbjct: 631 RQDAIGELIRMPTELQEVRALLAPMPDFERNLAQIHLFGNKQIKQMDHPDSRAILFEEKL 690
Query: 665 --SLKIQYFNKVLCGFEDILALVEKLSIFADLKGSLKSYLTEIPSS------LTTVLEAW 716
K+Q F VL GF D+ L ++F K +L +T++P S L+ L+ +
Sbjct: 691 YNKQKLQGFMAVLKGFNDLTKLP---TMFHQCKTTLLKRITQLPESGGSFPDLSKELQYF 747
Query: 717 SNAFDRNLAVKDGVIVPNRGVEPEFDESMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDS 776
+ AFD + A K GVI P G++ E+D +MD I +E +L+ L + ++ I + S
Sbjct: 748 ATAFDHDAAAKTGVIAPQAGMDAEYDAAMDSIGEVEKRLKTYLVEQERHF-GCRITYFGS 806
Query: 777 GKEIYTIEVPMAATRNVPHEWT---QMAANKSFKRYYSADVQRLARQMAEAREMHKVLED 833
K+ Y ++VP + +T Q K +RY +A+ + L + M A + ++
Sbjct: 807 DKKRYQLDVPESHASKANKSYTLEGQTKGKKPSRRYTTAETRALLKDMQHAEDTRNMVLK 866
Query: 834 DLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETNE 893
DL RL++KF+NHY+ W I ++N+D + SLA + C P+LV ++
Sbjct: 867 DLARRLFEKFSNHYDQ-WKQCIDCVANLDVLGSLAEYA-GQQMVICVPELV-------SD 917
Query: 894 KLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLG--KDAPQLGLLTGANAAGKSTVLRMT 951
+I+ +E HPC N A +IPN + LG +AP L LLTG N GKST++R
Sbjct: 918 ADQPFIQLEEGYHPCAN-----ASTYIPNGLELGTASEAP-LSLLTGPNMGGKSTLMREV 971
Query: 952 CVAVILAQL 960
+ VI+AQ+
Sbjct: 972 GLLVIMAQI 980
>YCR092c [L] KOG0218 Mismatch repair MSH3
Length = 1047
Score = 219 bits (558), Expect = 2e-56
Identities = 231/999 (23%), Positives = 424/999 (42%), Gaps = 131/999 (13%)
Query: 222 KSQGKHTKFNKTN-GERYQWLVHERDAEGRDKSDPDYDPRTLYIPGDA----WSKFTPFE 276
K+ G T FN + ++ ++ R E + D + + ++ A +K TP +
Sbjct: 106 KTSGTSTTFNDIDFAKKLDRIMKRRSDENVEAEDDEEEGEEDFVKKKARKSPTAKLTPLD 165
Query: 277 KQYWEIKSKMWDCILFFKKGKFFELYEKDAHLGHHLFDLKIAGG------------GRAN 324
KQ ++K D +L + G ++ + +DA + +K+ G
Sbjct: 166 KQVKDLKMHHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQDCNHRQ 225
Query: 325 MQLAGVPEMSFDYWASQFIQYGYKVAKVDQKESMLAKEMREGSK--GIVERELQCVLTSG 382
P++ + + + + KVA V+Q E+ K+ G+ + ER++ V T
Sbjct: 226 FAYCSFPDVRLNVHLERLVHHNLKVAVVEQAETSAIKKHDPGASKSSVFERKISNVFTKA 285
Query: 383 TLTDSEMLKSDLATYCVAVREEPITYYDEEILALP------KTGKYFGFAAIDTATGHID 436
T + +R + I I AL K KY +++ G +
Sbjct: 286 TFGVNSTF---------VLRGKRILGDTNSIWALSRDVHQGKVAKY-SLISVNLNNGEVV 335
Query: 437 LLEFEDDEECSQ-LDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPEAIINQRTSKEFY 495
EFE+ + L + +P EV++ ++ K K + P K+ Y
Sbjct: 336 YDEFEEPNLADEKLQIRIKYLQPIEVLVNTDDLPLHVAKFFKDISCP------LIHKQEY 389
Query: 496 DFEKTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGGLLSYLQWLKLDTSLVTMG 555
D E D ++ + K M+ + S K+ H +++ L+
Sbjct: 390 DLE---DHVV--QAIKVMNEKIQLSPSLIRLVSKLYSHM-------VEYNNEQVMLIP-- 435
Query: 556 QVEEYNPVRSQTCLALDGITLQNLEIFANTYDGTDRGSLFKLINRAITPMGKRKLRKWVM 615
Y+P S+ + LD +LQ+L+IF T+DG +GSLF L++ T G R LR+W++
Sbjct: 436 --SIYSPFASKIHMLLDPNSLQSLDIF--THDG-GKGSLFWLLDHTRTSFGLRMLREWIL 490
Query: 616 HPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XRMLSRVH---SCSLKIQ 669
PL+ + I R L+R+ + ++
Sbjct: 491 KPLVDVHQIEERLDAIECITSEINNSIFFESLNQMLNHTPDLLRTLNRIMYGTTSRKEVY 550
Query: 670 YFNKVLCGFEDILALVEK--------------------LSIFADLKGSLKSYLTEIPSSL 709
++ K + F D + + +F++L L + T++P L
Sbjct: 551 FYLKQITSFVDHFKMHQSYLSEHFKSSDGRIGKQSPLLFRLFSELNELLST--TQLPHFL 608
Query: 710 TTVLEAWSNAFDRNLAVKDGVIVPNRGVEPEFDESMDRIQGIEDQLQECLTQYKKLLKSS 769
T + + + + V D + N + + + QL+E L + +K LK
Sbjct: 609 TMINVSAVMEKNSDKQVMDFFNLNNYDCSEGIIKIQRESESVRSQLKEELAEIRKYLKRP 668
Query: 770 NIQFKDSGKEIYTIEVPMAATRNVPHEWTQMAANKSFKRYYSADVQRLARQMAEAREMHK 829
+ F+D Y IEV + +++P +W ++ K R+ + Q+L +++ +++
Sbjct: 669 YLNFRDEVD--YLIEVKNSQIKDLPDDWIKVNNTKMVSRFTTPRTQKLTQKLEYYKDL-L 725
Query: 830 VLEDDLKNRLYKKFTNHYNAVWLPTIQAISNI---DCIISLARTSESLGFPACRPKLVEG 886
+ E +L+ YK+F N A + + N+ DCI+SLA TS ++ + RP V G
Sbjct: 726 IRESELQ---YKEFLNKITAEYTELRKITLNLAQYDCILSLAATSCNVNY--VRPTFVNG 780
Query: 887 LHPETNEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKST 946
I K R+P S ++PND+++ + ++ ++TG N GKS+
Sbjct: 781 QQA---------IIAKNARNPIIE---SLDVHYVPNDIMMSPENGKINIITGPNMGGKSS 828
Query: 947 VLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILD 1006
+R + I+AQ+G ++P EE + + ++TR+GA D+I+ G STF VE+ + IL
Sbjct: 829 YIRQVALLTIMAQIGSFVPAEEIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILK 888
Query: 1007 LVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQ-SLGFFATHYAALGSSFTNHPN 1065
RSLL++DE+GRG + DG AI+ A++ + + L F TH+ LG P
Sbjct: 889 NCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFSELSDCPLILFTTHFPMLGE--IKSPL 946
Query: 1066 VQPLKMAILVD----EESRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAEN 1121
++ M + + E+ +V FLYKL G + S+GM+VA + + + +++ A +E
Sbjct: 947 IRNYHMDYVEEQKTGEDWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEE 1006
Query: 1122 LEHTSKLIKERKNLHQSINPVPLGLQSDVVRLVYGDGLT 1160
L +SIN L L S + R++ D +T
Sbjct: 1007 LR------------KESINEDALKLFSSLKRILKSDNIT 1033
>Hs4557761 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 934
Score = 219 bits (558), Expect = 2e-56
Identities = 218/895 (24%), Positives = 388/895 (42%), Gaps = 107/895 (11%)
Query: 275 FEKQYWEIKSKMWDCILFFKKGKFFELYEKDAHLG-HHLFD----LKIAG-GGRANMQLA 328
F + + + K + F +G F+ + +DA L +F +K G G N+Q
Sbjct: 19 FVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPAGAKNLQSV 78
Query: 329 GVPEMSFDYWASQFI---QYGYKVAKVDQKESMLAKEMREGSKGIVERE--LQCVLTSGT 383
+ +M+F+ + + QY +V K R G+K E + L + G
Sbjct: 79 VLSKMNFESFVKDLLLVRQYRVEVYK-----------NRAGNKASKENDWYLAYKASPGN 127
Query: 384 LTDSEML---KSDLATYCVAVREEPITYYDEEILALPKTGKYFGFAAIDTATGHIDLLEF 440
L+ E + +D++ + V ++ D + + G +D+ + L EF
Sbjct: 128 LSQFEDILFGNNDMSA-SIGVVGVKMSAVDGQ--------RQVGVGYVDSIQRKLGLCEF 178
Query: 441 EDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPEAIINQRTSKEFY--DFE 498
D+++ S L+ ++ Q P E ++ K+ + + +I +R +F D
Sbjct: 179 PDNDQFSNLEALLIQIGPKECVLPGGETAGDMGKLRQIIQRGGILITERKKADFSTKDIY 238
Query: 499 KTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGGLLSYLQWLKLDTSLVTMGQVE 558
+ + L+ + + M+ VL E +V + ++ +L+ L D++ GQ E
Sbjct: 239 QDLNRLLKGKKGEQMNS--AVLP---EMENQVAVSSLSAVIKFLELLSDDSNF---GQFE 290
Query: 559 EYNPVRSQTCLALDGITLQNLEIFANTY-DGTDRGSLFKLINRAITPMGKRKLRKWVMHP 617
SQ + LD ++ L +F + D T SL L+N+ TP G+R + +W+ P
Sbjct: 291 LTTFDFSQY-MKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQP 349
Query: 618 LLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMLSRVHSCSLKIQYFNKVLCG 677
L+ I +L R + + F +
Sbjct: 350 LMDKNRIEERLNLVEAFVEDAELRQTLQED---------LLRRFPDLNRLAKKFQRQAAN 400
Query: 678 FEDILALVEKLSIFADLKGSLKSY---------------LTEIPSSLTTVLEAWSNAFDR 722
+D L + ++ ++ +L+ + LT++ S + E D
Sbjct: 401 LQDCYRLYQGINQLPNVIQALEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDM 460
Query: 723 NLAVKDGVIVPNRGVEPEFDESMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYT 782
+ +V +P FD ++ ++ I + L++ + L+ ++ D GK+I
Sbjct: 461 DQVENHEFLV-----KPSFDPNLSELREIMNDLEKKMQS--TLISAARDLGLDPGKQIKL 513
Query: 783 IEVPMAAT--RNVPHEWTQMAANKSFKRYYSADVQRLARQMAEAR--------EMHKVLE 832
R E + NK+F + D+Q+ + ++ +K
Sbjct: 514 DSSAQFGYYFRVTCKEEKVLRNNKNFS---TVDIQKNGVKFTNSKLTSLNEEYTKNKTEY 570
Query: 833 DDLKNRLYKKFTNHYNAVWLPTIQAISNI----DCIISLARTSESLGFPACRPKLVEGLH 888
++ ++ + K+ N ++ ++ +Q ++++ D ++S A S P RP ++E
Sbjct: 571 EEAQDAIVKEIVN-ISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILE--- 626
Query: 889 PETNEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVL 948
K G I K RH C + A FIPNDV KD ++TG N GKST +
Sbjct: 627 -----KGQGRIILKASRHACVEVQDEIA--FIPNDVYFEKDKQMFHIITGPNMGGKSTYI 679
Query: 949 RMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLV 1008
R T V V++AQ+GC++PCE AE + VD I+ R+GA D+ ++G STF E+ ET IL
Sbjct: 680 RQTGVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSA 739
Query: 1009 TNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPNVQP 1068
T SL+++DELGRG S+ DGF +A A+ ++AT I + FATH+ L + P V
Sbjct: 740 TKDSLIIIDELGRGTSTYDGFGLAWAISEYIATKIGAFCMFATHFHELTALANQIPTVNN 799
Query: 1069 LKMAILVDEESRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLE 1123
L + L EE+ +T LY++ G D SFG+HVA + P+ V++ A A LE
Sbjct: 800 LHVTALTTEET--LTMLYQVKKGVCDQSFGIHVAELANFPKHVIECAKQKALELE 852
>YOL090w [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 964
Score = 206 bits (523), Expect = 2e-52
Identities = 210/816 (25%), Positives = 339/816 (40%), Gaps = 131/816 (16%)
Query: 424 GFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIME----KSNVCSLAQKIIKFN 479
G A IDT + +L+ D+E S L++ + Q E +++ SN + QK+I
Sbjct: 158 GVAFIDTTAYKVGMLDIVDNEVYSNLESFLIQLGVKECLVQDLTSNSNSNAEMQKVINVI 217
Query: 480 AQPEAIINQRTSKEFY--DFEKTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGG 537
+ ++ + EF D E +L+ + S+ + K+ A
Sbjct: 218 DRCGCVVTLLKNSEFSEKDVELDLTKLLGDDLALSLP----------QKYSKLSMGACNA 267
Query: 538 LLSYLQWLKLDTSLVTMGQVEEYNPV--RSQTCLALDGITLQNLEIFA----NTYDGTDR 591
L+ YLQ L QV +Y V + + + LD ++ L +F N + +
Sbjct: 268 LIGYLQLLS------EQDQVGKYELVEHKLKEFMKLDASAIKALNLFPQGPQNPFGSNNL 321
Query: 592 G--------------SLFKLINRAITPMGKRKLRKWVMHPLLKIEDINXXXXXXXXXXXX 637
SLF+L+N T G R L +W+ PL I++IN
Sbjct: 322 AVSGFTSAGNSGKVTSLFQLLNHCKTNAGVRLLNEWLKQPLTNIDEINKRHDLVDYL--- 378
Query: 638 XXXXXXXXXXXXXXXXXXRMLSRVHSCSLKIQYFNKVLCGFEDILALVEKLSIFADLKGS 697
+ L+ ++ L DI L +KL+ +L+
Sbjct: 379 -----------------------IDQIELRQMLTSEYLPMIPDIRRLTKKLNKRGNLEDV 415
Query: 698 LKSY-----LTEIPSSLTTVLEAWSNAFDRNLAVKDGVIVP-NRGVEP--EFDESMDRIQ 749
LK Y + EI T+ LE S N V+ + P + VEP +F+E ++
Sbjct: 416 LKIYQFSKRIPEIVQVFTSFLEDDSPTEPVNELVRSVWLAPLSHHVEPLSKFEEMVETTV 475
Query: 750 GIE--DQLQECL--TQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVP----------- 794
++ ++ E + ++ + L + EI++I + A
Sbjct: 476 DLDAYEENNEFMIKVEFNEELGKIRSKLDTLRDEIHSIHLDSAEDLGFDPDKKLKLENHH 535
Query: 795 -HEWTQMAAN------KSFKRYYSADVQRLA-----RQMAEAREMHKVLE---DDLKNRL 839
H W + K+Y + +Q+ +L+ D ++ L
Sbjct: 536 LHGWCMRLTRNDAKELRKHKKYIELSTVKAGIFFSTKQLKSIANETNILQKEYDKQQSAL 595
Query: 840 YKKFTN---HYNAVWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLN 896
++ N Y V+ ++++D I S A TS P RPKL HP +E+
Sbjct: 596 VREIINITLTYTPVFEKLSLVLAHLDVIASFAHTSSYAPIPYIRPKL----HPMDSERRT 651
Query: 897 GYIRFKELRHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVI 956
I RHP M + FI NDV L ++TG N GKST +R V +
Sbjct: 652 HLI---SSRHPVLEMQDDIS--FISNDVTLESGKGDFLIITGPNMGGKSTYIRQVGVISL 706
Query: 957 LAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVV 1016
+AQ+GC++PCEEAE VD I+ R+GA D+ ++G STF VE+ ET IL + SL++V
Sbjct: 707 MAQIGCFVPCEEAEIAIVDAILCRVGAGDSQLKGVSTFMVEILETASILKNASKNSLIIV 766
Query: 1017 DELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPNVQPLKMAILVD 1076
DELGRG S+ DGF +A A+ H+A+ I FATH+ L PNV+ + + ++
Sbjct: 767 DELGRGTSTYDGFGLAWAIAEHIASKIGCFALFATHFHELTELSEKLPNVKNMHVVAHIE 826
Query: 1077 E-------ESRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLEHTSKLI 1129
+ + ++T LYK+ G SD SFG+HVA + P +V A A L+
Sbjct: 827 KNLKEQKHDDEDITLLYKVEPGISDQSFGIHVAEVVQFPEKIVKMAKRKANELDDLKTNN 886
Query: 1130 KERKNLHQSINPVPLG------LQSDVVRLVYGDGL 1159
++ K S+ V G L + +R V +GL
Sbjct: 887 EDLKKAKLSLQEVNEGNIRLKALLKEWIRKVKEEGL 922
>CE21000 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 849
Score = 204 bits (520), Expect = 5e-52
Identities = 186/730 (25%), Positives = 321/730 (43%), Gaps = 57/730 (7%)
Query: 427 AIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTE-VIMEKSNVCSLAQKIIKFNAQPEAI 485
A D I + E+ D SQ + + PTE +++ + +V A+KI + E
Sbjct: 147 AWDAGNVRIVISEYIDTPSFSQTEQCIFGLCPTEYILVNEGSVAPKAKKIASMFTRMEVH 206
Query: 486 INQRTSKEFYDFEKTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGGLLSYLQWL 545
Q+ K +W V++S + K + LQ L
Sbjct: 207 NKQQ--------------------LKPKSQWSDVIESVHLDYKDEAEKQNENIKECLQIL 246
Query: 546 KLDTSLVTMGQVEEYNPVRSQTC--LALDGITLQNLEIFANTYDGTDRGS---LFKLINR 600
+ + E+Y+ T + +D ++ LE+F Y+ ++ + L+ ++N+
Sbjct: 247 HSNAA-DEYSISEKYSIFNYGTHGNMLIDSCAVEALELFQLNYNYLEKSNNLTLYNVLNK 305
Query: 601 AITPMGKRKLRKWVMHPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRMLSR 660
T G++ LR W+ PL +I+ IN L+R
Sbjct: 306 CKTLPGEKLLRDWLSRPLCQIDHINERLDIVEALFENQTIRQKLRDSILARMPDCSQLAR 365
Query: 661 --VHSCSLK-IQYFNKVLCGFE----DILALVEKLSIFADLKGSLKSYLTEIPSSLTTVL 713
+ C+L+ + F + E ++ L E + LKS +TEI +
Sbjct: 366 RLMRKCTLQDLNRFYQAATLLETVEMQLIQLSEAEQFAPSINRLLKSEITEILKKVERFQ 425
Query: 714 EAWSNAFDRNLAVKDGVIVPNRGVEPEFDESMDRIQGIEDQLQECLTQYKKLLKSSNIQF 773
FD + ++ I PE E ++++ +E ++ +Y + N++
Sbjct: 426 VLCDEFFDFDYEKENKEIRVRVDFVPEIQEISEKLEQMERVAEKLRKKYSAKFECDNLKL 485
Query: 774 KDSGKEIYTIEVPMAATRNVPHEWTQM--AANKSFKRYYSADVQRLARQMAEAREMHKVL 831
+ + + V + +++ + + S ++ ++ + + E +
Sbjct: 486 DKNSQYGFYFRVTLKEEKSIRKKDVHILETTKGSGVKFSVGELSDINDEFLEFHLKYTRA 545
Query: 832 EDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPET 891
E+++ + L KK + + Q I+ +D +SL+ + + RP L+ P
Sbjct: 546 EEEVISMLCKK-AEEFIPLIPAMAQLIATLDVFVSLSTFAATSSGIYTRPNLL----PLG 600
Query: 892 NEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMT 951
+++L K+ RHP +S K FIPNDVVL D +L +LTGAN GKST LR
Sbjct: 601 SKRL----ELKQCRHPVIE--GNSEKPFIPNDVVL--DKCRLIILTGANMGGKSTYLRSA 652
Query: 952 CVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNR 1011
++++LAQ+G ++PC A + VD I TR+GASD QG STF E+ + IL T
Sbjct: 653 ALSILLAQIGSFVPCSSATISVVDGIFTRVGASDKQSQGISTFMAEMLDCSAILQRATKN 712
Query: 1012 SLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPNVQPLKM 1071
S +V+DELGRG S+ DGF IA A+ + IQ L FATH+ +G P L+M
Sbjct: 713 SFVVIDELGRGTSTFDGFGIASAIAQDILNRIQCLSIFATHFHEMG-KLAEQPGAVALQM 771
Query: 1072 AILVDEESRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLEHTSKLI-- 1129
+ + E+ + LYK+ +G + SFG+ VA M GI +V++ A+ E LE KL+
Sbjct: 772 GVQI--ENNEIHMLYKVFEGVAQCSFGLQVAKMVGIDENVINKAAQLLEGLE--KKLVID 827
Query: 1130 -KERKNLHQS 1138
K++K L +S
Sbjct: 828 SKKKKELLES 837
>SPBC24C6.12c [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 434
Score = 182 bits (462), Expect = 3e-45
Identities = 107/296 (36%), Positives = 158/296 (53%), Gaps = 30/296 (10%)
Query: 856 QAISNIDCIISLARTSESLGFPACRPKLVEGL-----HPETNEKLN-------------- 896
Q I+++D I+S A S P RP +V+ H +++ L+
Sbjct: 66 QVIAHLDVILSFAHASTVAVIPYVRPNIVDSSIAQEKHGQSSNILDIVSLEDTPNFEEIR 125
Query: 897 --------GYIRFKELRHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVL 948
+ K+ RHPC + +FIPNDV L + +L ++TG N GKST +
Sbjct: 126 RTLENNHCARLYLKQARHPCLE--AQDDVKFIPNDVNLEHGSSELLIITGPNMGGKSTYI 183
Query: 949 RMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLV 1008
R V ++AQ+GC +PCE A+ +D I+ R+GASD+ ++G STF E+ ET IL
Sbjct: 184 RQVGVITVMAQIGCPVPCEVADLDIIDAILARVGASDSQLKGISTFMAEMLETATILRAA 243
Query: 1009 TNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPNVQP 1068
T RSL+++DELGRG S++DGF +A A+ H+ T I FATHY + V+
Sbjct: 244 TPRSLIIIDELGRGTSTTDGFGLAWAITEHIVTQIGCFCLFATHYHEMTKLSEEITTVKN 303
Query: 1069 LKMAILV-DEESRNVTFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLE 1123
L + V D ES++V LY + +G SD SFG+HVA + P +++ AS A LE
Sbjct: 304 LHVTAYVGDSESKDVALLYNVCEGASDRSFGIHVAKLAHFPPKIIEMASNKAAELE 359
>7298155 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 854
Score = 167 bits (422), Expect = 1e-40
Identities = 99/284 (34%), Positives = 152/284 (52%), Gaps = 14/284 (4%)
Query: 858 ISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAK 917
++ +DC++S A + S P RPK++E E + +++RHPC +
Sbjct: 534 LAQLDCLVSFAIAARSAPTPYVRPKMLEEGARE--------LVLEDVRHPCLEL--QEHV 583
Query: 918 EFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRI 977
FI N V K+ + ++TG N GKST +R AV++A +G ++PC A + VD I
Sbjct: 584 NFIANSVDFKKEECNMFIITGPNMGGKSTYIRSVGTAVLMAHIGAFVPCSLATISMVDSI 643
Query: 978 MTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLH 1037
+ R+GASDNI++G STF VE+ ET I+ T++SL+++DELGRG S+ +G IA ++
Sbjct: 644 LGRVGASDNIIKGLSTFMVEMIETSGIIRTATDKSLVIIDELGRGTSTYEGCGIAWSIAE 703
Query: 1038 HVATHIQSLGFFATHYAALGSSFTNHPNVQPLKMAILVDEESRNVTFLYKLVDGKSDGSF 1097
H+A + FATH+ + V+ MA + D + + T LY++ G + SF
Sbjct: 704 HLAKETKCFTLFATHFHEITKLAETLSTVKNCHMAAVADAD--DFTLLYQVRSGVMEKSF 761
Query: 1098 GMHVASMCGIPRSVVDNASIAAENL--EHTSKLIKERKNLHQSI 1139
G+ VA + P VV NA EH K KE K L + I
Sbjct: 762 GIQVARLANFPEHVVQNAQEVYNEFEDEHVDKQKKEDKALLEKI 805
>At4g25540 [L] KOG0218 Mismatch repair MSH3
Length = 1076
Score = 162 bits (411), Expect = 2e-39
Identities = 123/444 (27%), Positives = 206/444 (45%), Gaps = 44/444 (9%)
Query: 692 ADLKGSLKSYLTEIPSSLTTVLEAWS--NAFDRNLAVKDG---VIVPNRGVEPEFDESMD 746
A ++ +L L + SS V A +A ++ AV+ +++ + PE E+
Sbjct: 593 ATVRSTLLRKLISVISSPVVVDNAGKLLSALNKEAAVRGDLLDILITSSDQFPELAEARQ 652
Query: 747 RIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQMAANKSF 806
+ I ++L + ++K L N++F + IE+P+ + VP W ++ + K
Sbjct: 653 AVLVIREKLDSSIASFRKKLAIRNLEFLQVSGITHLIELPVDS--KVPMNWVKVNSTKKT 710
Query: 807 KRYYSADVQRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIIS 866
RY+ ++ ++A A E ++ + K F+ +Y + +QA++ +DC+ S
Sbjct: 711 IRYHPPEIVAGLDELALATEHLAIVNRASWDSFLKSFSRYYTD-FKAAVQALAALDCLHS 769
Query: 867 LARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVL 926
L+ S + + RP+ V+ P I + RHP + F+PND +L
Sbjct: 770 LSTLSRNKNY--VRPEFVDDCEPVE-------INIQSGRHPVLE--TILQDNFVPNDTIL 818
Query: 927 GKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDN 986
+ ++TG N GKS +R + I+AQ+G ++P A+ +D + TR+GASD+
Sbjct: 819 HAEGEYCQIITGPNMGGKSCYIRQVALISIMAQVGSFVPASFAKLHVLDGVFTRMGASDS 878
Query: 987 IMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSL 1046
I G+STF EL +ELGRG S+ DG AIA A L H+ + L
Sbjct: 879 IQHGRSTFLEEL------------------NELGRGTSTHDGVAIAYATLQHLLAEKRCL 920
Query: 1047 GFFATHYAALGSSFTNHP-NVQPLKMAILVDEESR------NVTFLYKLVDGKSDGSFGM 1099
F THY + P +V ++ L ++ + +VT+LYKLV G SFG
Sbjct: 921 VLFVTHYPEIAEISNGFPGSVGTYHVSYLTLQKDKGSYDHDDVTYLYKLVRGLCSRSFGF 980
Query: 1100 HVASMCGIPRSVVDNASIAAENLE 1123
VA + IP S + A A LE
Sbjct: 981 KVAQLAQIPPSCIRRAISMAAKLE 1004
Score = 80.1 bits (196), Expect = 2e-14
Identities = 86/382 (22%), Positives = 151/382 (39%), Gaps = 49/382 (12%)
Query: 263 YIPGDAWS-KFTPFEKQYWEIKSKMWDCILFFKKGKFFELYEKDAHLGHHLFDLKIAGGG 321
Y+P + S K+TP E+Q E+KSK D +L + G + + +DA + + +
Sbjct: 94 YVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFGEDAEIAARVLGI------ 147
Query: 322 RANMQLAGVPEMSFDYWASQFIQYGYKVAKVDQKESMLAKEMREGSKGIVERELQCVLTS 381
+ + F+ YK+ V Q E+ K G R L + T
Sbjct: 148 -------------YAHMDHNFMTARYKIGVVKQTETAAIKSHGANRTGPFFRGLSALYTK 194
Query: 382 GTLTDSEMLKSDL---------ATYCVAVREEPITYYDEEILALPKTGKY---FGFAAID 429
TL +E + + + V V +E + E L + G ++
Sbjct: 195 ATLEAAEDISGGCGGEEGFGSQSNFLVCVVDERVK---SETLGCGIEMSFDVRVGVVGVE 251
Query: 430 TATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPEAIIN-Q 488
+TG + EF D+ S L+ ++ P E+++ + + +K + +A P + + +
Sbjct: 252 ISTGEVVYEEFNDNFMRSGLEAVILSLSPAELLLGQP-LSQQTEKFLVAHAGPTSNVRVE 310
Query: 489 RTSKEFYDFEKTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGGLLSYLQWLKLD 548
R S + + DE+I+ S + E +K + + L +
Sbjct: 311 RASLDCFSNGNAVDEVISLCEKISAGNLEDDKEMKLEAAEKGMSCLTVHTIMNMPHLTVQ 370
Query: 549 TSLVTMGQVEEYNPVR------------SQTCLALDGITLQNLEIFANTYDGTDRGSLFK 596
+T ++++ R S T + L TLQ LE+ N DG++ GSLF
Sbjct: 371 ALALTFCHLKQFGFERILYQGASFRSLSSNTEMTLSANTLQQLEVVKNNSDGSESGSLFH 430
Query: 597 LINRAITPMGKRKLRKWVMHPL 618
+N +T G R LR WV HPL
Sbjct: 431 NMNHTLTVYGSRLLRHWVTHPL 452
>CE24714 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 842
Score = 139 bits (349), Expect = 3e-32
Identities = 176/755 (23%), Positives = 309/755 (40%), Gaps = 92/755 (12%)
Query: 422 YFGFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIK---F 478
+ G A DT I L EF D E + L T+++ + +++++ N + K++
Sbjct: 67 HIGIALHDTCFPEIHLCEFVDSREYTTLKTMINVHEAFDIVIQNGNEERGSTKLLGEALM 126
Query: 479 NAQPEAIINQRTSKEFYDF--EKTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFG 536
A PEA + +SK F E+ L+ E TV + +G A
Sbjct: 127 TAFPEASLQSISSKYFNSERGERQLQSLMNAEV-------STVSEGCLRRTLALG--ALA 177
Query: 537 GLLSYLQWLKLDTSLVTMGQVEEYNPVRSQTCLALDGITLQNLEIF-------ANTYDGT 589
LL Y+ + V +++E + TC+ +D ++ ++LEI A +
Sbjct: 178 VLLKYIHETRCVFFRVKSLRIKEMGV--NDTCM-IDFVSWESLEIVDADDASKARKFQMK 234
Query: 590 DRGSLFKLINRAITPMGKRKLRKWVMHPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXX 649
+ +L ++N +T G R LR V+ P + I
Sbjct: 235 QKRTLMSVLNHTVTTNGYRLLRSSVLQPSTDVYLIQSRQEAIEELIGKPQLKDKLRRTLS 294
Query: 650 XXXXXXRMLSRVHSCS---------------LKIQYFNKVLCGFEDIL--------ALVE 686
R+++ S +K+ + KV+ G +L L+E
Sbjct: 295 RAHELDRVIAMCIQTSTSWTVRESEAKINQIIKLMHTLKVIQGIRTLLHSAKMKSNILIE 354
Query: 687 KLSIFADLK-GSLKSYLTEIPSSLTTVLEAWSNAFD----RNLAVKDGVIVPNRGVEPEF 741
K D + + + L E ++L+ N+ + A++ V V +
Sbjct: 355 KTEFLKDPRFDQIMNILVEKVDD--SLLDGKKNSLHLQNTKCYAIRHFVAVQLDLARQTY 412
Query: 742 DESMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQMA 801
+E I+ +E+ + +Y S + F S YT A + +P + +
Sbjct: 413 EEI---IRNVEETGAREIAEYFHGNSSVRLSFSQSRGFHYTFVTRQAESVTIPRYFLDVF 469
Query: 802 ANKSFKRYYSADV----QRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQA 857
N++ + S V RL + +AE V+ D+ + Y A+ A
Sbjct: 470 RNRTTVTFNSRKVIAYNDRLEQVVAEMFLASDVIVCDMIEEMQPMIPVLYYAM-----DA 524
Query: 858 ISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAK 917
+S+ID + LA S+ C+P + RHP + S +
Sbjct: 525 LSSIDFLCGLATYSDLRD--TCKPTFGPSFS------------ISQGRHPILDWDDS--E 568
Query: 918 EFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRI 977
+ I ND L +D + G++TG N AGKST L+ T I+AQ+GC+IP A +RI
Sbjct: 569 KTITNDTCLTRDR-RFGIITGPNMAGKSTYLKQTAQLAIMAQIGCFIPANYASLPIFNRI 627
Query: 978 MTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLH 1037
+R+G +D +++ KS F E+S+ I+ SL+V+DEL R S+ +G AI A+
Sbjct: 628 FSRMGHNDELIRNKSAFASEMSDAAAIVQYADKNSLVVLDELARSTSTEEGIAITYAICE 687
Query: 1038 HVATHIQSLGFFATHYAALGSSFTNHPNVQPLKMAILVDEESRNVTFLYKLVDGKSDGS- 1096
V +QS F ATH+ + ++ N+ N + + + N T +KL+ G+ G
Sbjct: 688 KV-LKLQSYTFLATHFLDI-AALANYSNA--IDNYHFLPQTDENSTKKHKLLRGQYRGPL 743
Query: 1097 FGMHVASMCGIPRSVVDNA-SIAAE---NLEHTSK 1127
+G + + IP V+++A S+A E N+E T +
Sbjct: 744 YGFELVELSTIPDEVIEHAQSLATELRANVEDTER 778
>Hs4505253 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 834
Score = 137 bits (344), Expect = 1e-31
Identities = 179/773 (23%), Positives = 311/773 (40%), Gaps = 101/773 (13%)
Query: 422 YFGFAAIDTATGHIDLL-EFEDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNA 480
Y G A DT+ I + + D E L ++ + P V+ ++ + + K +
Sbjct: 60 YLGIAYYDTSDSTIHFMPDAPDHESLKLLQRVLDEINPQSVVTSAKQDENMTRFLGKLAS 119
Query: 481 Q-------PEAIINQRTSKEFYDFEKTFDELITHEYFKSMDRWPTV-----LKSYYETGK 528
Q PE I + E + L++ Y D L S
Sbjct: 120 QEHREPKRPEIIFLPSVD---FGLEISKQRLLSGNYSFIPDAMTATEKILFLSSIIPFDC 176
Query: 529 KVGFHAFGGLLSYLQWLKLDTSLVTMGQVEEYN---PVRS------QTCLALDGITLQNL 579
+ A GGLL +L ++ L E+YN P+ + +D T L
Sbjct: 177 LLTVRALGGLLKFLGRRRIGVEL------EDYNVSVPILGFKKFMLTHLVNIDQDTYSVL 230
Query: 580 EIFAN--------TYDGTDRG-SLFKLINRAITPMGKRKLRKWVMHPLLKIEDINXXXXX 630
+IF + G G SLF ++NR G++ LR W P + +++
Sbjct: 231 QIFKSESHPSVYKVASGLKEGLSLFGILNRCHCKWGEKLLRLWFTRPTHDLGELSSRLDV 290
Query: 631 XXXXXXXXXXXXXXXXXXXXXXXXX--RMLSRVHSCSLKI---QYFNKVL---CGFEDIL 682
+L R+ K+ Q K + G D
Sbjct: 291 IQFFLLPQNLDMAQMLHRLLGHIKNVPLILKRMKLSHTKVSDWQVLYKTVYSALGLRDAC 350
Query: 683 -ALVEKLSIFADLKGSLKSYLTEIPSSLTTVLEAWSNAFDRNLAVKDGVIVPNRGVEPEF 741
+L + + +F D+ L I S + V++ F+ +LA ++PN ++PE
Sbjct: 351 RSLPQSIQLFRDIAQEFSDDLHHIASLIGKVVD-----FEGSLAENRFTVLPN--IDPEI 403
Query: 742 DESMDRIQGIEDQLQECLTQYKKLLKS-----SNIQFKDSGKEIYTIEVP--MAATRNVP 794
DE R+ G+ L E + + L S S I G + +P + A+
Sbjct: 404 DEKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEI 463
Query: 795 HEWTQMAANKSFKRYYSADVQRLARQMA----EAREMHKVLEDDLKNRLYKKFTNHYNAV 850
+ M ++ Y SA + L + E R+ +L L+ ++ + AV
Sbjct: 464 NGLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARA-----AV 518
Query: 851 WLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFN 910
+ S +D +++LA + G+ P + ++ G +R + RHP
Sbjct: 519 LTRVLDLASRLDVLLALASAARDYGYS----------RPRYSPQVLG-VRIQNGRHPLME 567
Query: 911 MGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAE 970
+ A+ F+PN G D ++ ++TG N++GKS L+ + +A +G ++P EEAE
Sbjct: 568 L---CARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAE 624
Query: 971 FTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFA 1030
VD I TR+ + ++I G STF ++L++ K ++ T +SL+++DE G+G ++ DG A
Sbjct: 625 IGAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLA 684
Query: 1031 IAEAVLHH------VATHIQSLGFFATHYAALG--SSFTNHPNVQPLKMAILVDEESRNV 1082
+ AVL H HI F AT++ +L P VQ L M E+ ++
Sbjct: 685 LLAAVLRHWLARGPTCPHI----FVATNFLSLVQLQLLPQGPLVQYLTMETC--EDGNDL 738
Query: 1083 TFLYKLVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLEHTSKLIKERKNL 1135
F Y++ +G + S H A+ G+P +V +L + K IK K+L
Sbjct: 739 VFFYQVCEGVAKASHASHTAAQAGLPDKLVARGK-EVSDLIRSGKPIKPVKDL 790
>Hs21361940 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 851
Score = 132 bits (332), Expect = 3e-30
Identities = 120/468 (25%), Positives = 215/468 (45%), Gaps = 44/468 (9%)
Query: 683 ALVEKLSIFADLKGSLKSYLTEIPSSLTTVLEAWSNAFDRNLAVKDGVIVPNRGVEPEFD 742
+L + + +F D+ L I S + V++ F+ +LA ++PN ++PE D
Sbjct: 369 SLPQSIQLFRDIAQEFSDDLHHIASLIGKVVD-----FEGSLAENRFTVLPN--IDPEID 421
Query: 743 ESMDRIQGIEDQLQECLTQYKKLLKS-----SNIQFKDSGKEIYTIEVP--MAATRNVPH 795
E R+ G+ L E + + L S S I G + +P + A+ +
Sbjct: 422 EKKRRLMGLPSFLTEVARKELENLDSRIPSCSVIYIPLIGFLLSIPRLPSMVEASDFEIN 481
Query: 796 EWTQMAANKSFKRYYSADVQRLARQMA----EAREMHKVLEDDLKNRLYKKFTNHYNAVW 851
M ++ Y SA + L + E R+ +L L+ ++ + AV
Sbjct: 482 GLDFMFLSEEKLHYRSARTKELDALLGDLHCEIRDQETLLMYQLQCQVLARA-----AVL 536
Query: 852 LPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNM 911
+ S +D +++LA + G+ P + ++ G +R + RHP +
Sbjct: 537 TRVLDLASRLDVLLALASAARDYGYS----------RPRYSPQVLG-VRIQNGRHPLMEL 585
Query: 912 GSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEF 971
A+ F+PN G D ++ ++TG N++GKS L+ + +A +G ++P EEAE
Sbjct: 586 ---CARTFVPNSTECGGDKGRVKVITGPNSSGKSIYLKQVGLITFMALVGSFVPAEEAEI 642
Query: 972 TPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAI 1031
VD I TR+ + ++I G STF ++L++ K ++ T +SL+++DE G+G ++ DG A+
Sbjct: 643 GAVDAIFTRIHSCESISLGLSTFMIDLNQVAKAVNNATAQSLVLIDEFGKGTNTVDGLAL 702
Query: 1032 AEAVLHHVATHIQSLG--FFATHYAALG--SSFTNHPNVQPLKMAILVDEESRNVTFLYK 1087
AVL H + F AT++ +L P VQ L M E+ ++ F Y+
Sbjct: 703 LAAVLRHWLARGPTCPTVFVATNFLSLVQLQLLPQGPLVQYLTMETC--EDGNDLVFFYQ 760
Query: 1088 LVDGKSDGSFGMHVASMCGIPRSVVDNASIAAENLEHTSKLIKERKNL 1135
+ +G + S H A+ G+P +V +L + K IK K+L
Sbjct: 761 VCEGVAKASHASHTAAQAGLPDKLVARGK-EVSDLIRSGKPIKPVKDL 807
>At4g17380 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 574
Score = 126 bits (316), Expect = 2e-28
Identities = 70/165 (42%), Positives = 100/165 (60%), Gaps = 5/165 (3%)
Query: 905 RHPCFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYI 964
RHP S +F+ N + + +A + ++ G N +GKST L+ C+ VILAQ+GCY+
Sbjct: 360 RHPILE---SIHNDFVSNSIFMS-EATNMLVVMGPNMSGKSTYLQQVCLVVILAQIGCYV 415
Query: 965 PCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGS 1024
P A VDRI TR+G DN+ STF E+ ET I+ VTNRSL+V+DELGR S
Sbjct: 416 PARFATIRVVDRIFTRMGTMDNLESNSSTFMTEMRETAFIMQNVTNRSLIVMDELGRATS 475
Query: 1025 SSDGFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPNVQPL 1069
SSDG A+A + ++ + +++ FATH +L T +PNV+ L
Sbjct: 476 SSDGLAMAWSCCEYLLS-LKAYTVFATHMDSLAELATIYPNVKVL 519
>CE26678 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 1369
Score = 123 bits (309), Expect = 2e-27
Identities = 149/651 (22%), Positives = 259/651 (38%), Gaps = 69/651 (10%)
Query: 534 AFGGLLSYLQWLKL---DTSLVTMGQVEEYNPVRSQTCLALDGITLQNLEIFANTYD--- 587
+FG LL +L ++ D L ++ + +D T+Q L+I +
Sbjct: 240 SFGALLLFLDETRMGVTDDPLSVTSPIKSIKTFTLGNLVEIDFNTIQALDILPKETENKK 299
Query: 588 --GTDRGSLFKLINRAITPMGKRKLRKWVMHPLLKIEDINXXXXXXXXXXXXXXXXXXXX 645
G R SL++L+++ + +GK+ LRKW +P +D+
Sbjct: 300 TFGQGR-SLYQLMDKCRSTVGKKCLRKWFRNPTTDRDDL--------VSRQKCVHYFKQD 350
Query: 646 XXXXXXXXXXRMLSRVHSCSLKIQYFNKVL-------CGFEDILALVEKLSIFADLKGS- 697
+L RV + + Q F C + ALVE L+I S
Sbjct: 351 WNAEVTAKLSSILGRVKALNSVFQKFQSGTAQLIHWECFVSTVNALVEILNIIRQTPISK 410
Query: 698 ---LKSYLTEIPSSLTTVLEAWSNAFDRNLAVKDGVIVPNRGVEPEFDESMDRIQGIEDQ 754
++S L S + + + N + + G + G++ E DE D + +
Sbjct: 411 EFPVESDLLREVSEIAVIAGSIINFAESKI---QGRVTVMNGIDEELDEIRDTYENMPMV 467
Query: 755 LQECLTQYKKLL---KSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQMAANKSFKRYYS 811
L Q + L SN+ + + VP + T + + R +
Sbjct: 468 LTAIAKQEEARLGLPPYSNVACVYIPLVGFVLSVPRDYGVESQPDMTLLYSTHEDLRVRN 527
Query: 812 ADVQRLARQMAEAR----EMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIISL 867
A RL + + + + LK R+ KK + + + S ID +IS
Sbjct: 528 ATTSRLDDEFGDILMRLIDSQTAIILTLKTRVMKKKRSI-----IKLLSIASRIDVLISF 582
Query: 868 ARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVLG 927
+ G+ P LV+ I EL HP + K F+PN V G
Sbjct: 583 GLIAAQNGWNC--PALVD----------EPVIEAVELYHPISVLVVK--KSFVPNQVSSG 628
Query: 928 KDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNI 987
+D + ++TG NA GKS ++ + V L+ +G ++P A+ VDRI+TR+ D++
Sbjct: 629 RDGIKASIITGPNACGKSVYMKSIGIMVFLSHIGSFVPARHAKIGIVDRIVTRMFTVDSV 688
Query: 988 MQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLG 1047
+ G STF ++ + L T SL+++DE G+G + G ++ +V+ T+ + G
Sbjct: 689 LDGMSTFAKDVEQVALALRKATGNSLVIIDEFGKGTMTEVGLSLLASVM----TYWMNRG 744
Query: 1048 -------FFATHYAALGSSFTNHPNVQPLKMAILVDEESRNVTFLYKLVDGKSDGSFGMH 1100
F ++H+ AL + N+ ++ E + +L+++ G D SF +
Sbjct: 745 ADRCPHIFLSSHFHALPNYIPLETNIATFLTFTVLREAGGKIKYLFRMTPGLVDCSFALS 804
Query: 1101 VASMCGIPRSVVDNASIAAENLEHTSKLIKERKNLHQSINPVPLGLQSDVV 1151
VA GIP V+ A + L+ L+KE K + N L DVV
Sbjct: 805 VAKEEGIPPPVIGRACRIYKALK-AGTLLKEIKAEVSNDNEKQLVEDMDVV 854
>ECU03g0540 [L] KOG0219 Mismatch repair ATPase MSH2 (MutS family)
Length = 730
Score = 121 bits (304), Expect = 6e-27
Identities = 73/200 (36%), Positives = 111/200 (55%), Gaps = 16/200 (8%)
Query: 917 KEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDR 976
+++IPN + + + ++ ++TG N GKST L+ V +LA +GCY+P E A +D
Sbjct: 540 QDYIPNSIKM--EDRRMCVVTGPNMGGKSTFLKTCGVIALLAHMGCYVPAEYASIPILDG 597
Query: 977 IMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVL 1036
I TR+GA D G STF +E+++ +I L + SL+++DELGRG S+ DG +IA+AV
Sbjct: 598 IYTRVGAGDCSFTGSSTFMMEMADIARICRLSSPESLIIIDELGRGTSAVDGLSIAQAVK 657
Query: 1037 HHVATHIQSLGFFATHYAAL-GSSFTNHPNVQPLKMAILVDEESRNVTFLYKLVDGKSDG 1095
H+ +SL ATH+ L G N +S +Y++VDG D
Sbjct: 658 EHLILK-KSLCLCATHFPELCGDDVLNK------------KAKSDGTLLMYEVVDGICDT 704
Query: 1096 SFGMHVASMCGIPRSVVDNA 1115
SFG+ VA G P V++ A
Sbjct: 705 SFGIMVAEKVGFPAEVIEMA 724
>YFL003c [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 878
Score = 118 bits (295), Expect = 6e-26
Identities = 154/699 (22%), Positives = 279/699 (39%), Gaps = 78/699 (11%)
Query: 424 GFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKI---IKFNA 480
G I+ TG + L +F D + ++ + ++PTE+++ S++ K+ IKFN
Sbjct: 121 GLCIINCNTGQMYLSDFMDSQIYIRVVHKLQIYQPTEILIPSSSLAPTVSKLATMIKFNV 180
Query: 481 QPEAIINQRTSKEFYDFEKTFDELITHEYFKSMDRWPTVLKSYYETGKKVGFHAFGGLLS 540
I + + K F + D L + MD LK K A +S
Sbjct: 181 AETVKIEEGSRKCF----NSQDGLAAITKYL-MDDTKKDLKIEEIIDKTFALCAASAAIS 235
Query: 541 YLQWLKLDTSLVTMGQVEEYNPVRSQ-----TCLALDGITLQNLEIFANTYDGTDRGSLF 595
Y++ + +S + + +R Q + +D T++ LE+ N D SL+
Sbjct: 236 YMEEIISKSSR----NLNAFRKLRIQFEGTENTMLIDSKTVRGLELVENKLDKNGI-SLW 290
Query: 596 KLINRAITPMGKRKLRKWVMHPLLKIEDINXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX 655
K ++ T MG+R LR ++ PL I
Sbjct: 291 KFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRLEALEELKANDDLLQKLRLEMKSLPDLD 350
Query: 656 RMLSRV----HSCSLKIQYFNKVLCGFEDILA-----------LVEKLSIFADLKGSLKS 700
++ SR+ HS Q N VL E + + L++ I K
Sbjct: 351 KLFSRLLCINHSAIKPDQRINYVLLLKETLQSVKSLKDALNDQLIQSRLISETKKIFNND 410
Query: 701 YLTEIPSSLTTVLE---AWSNAF-----DRNLAVK---DGVIVPNRGVEPEFDESMDRIQ 749
+ EI + + + W+++ R+ AVK +G++ +R + E E R
Sbjct: 411 AIMEIEKLINSCINEDCVWASSAIQLLNQRSYAVKSDSNGLLDVSRQIYKEVKEEFFR-- 468
Query: 750 GIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNV---PHEWTQMAANKSF 806
+ED LT K+ N DS + Y T +V P + K++
Sbjct: 469 EVED-----LTAKNKINLDHNY---DSARGFYLRIKRQEFTDDVATLPDVFISRTIKKNY 520
Query: 807 KRYYSADVQRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQAISNIDCIIS 866
+ ++ + ++ E E +L ++ + L K H + +++ +A++ +D + S
Sbjct: 521 IECTTLNIIKKNARLKEVMEEILLLSEETVDELLDKIATHISELFM-IAEAVAILDLVCS 579
Query: 867 LARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSAKEFIPNDVVL 926
+ + T + ++ RHP K F+PN +
Sbjct: 580 FTYNLKENNY--------------TIPIFTNNLLIRDSRHPLLE---KVLKNFVPNTISS 622
Query: 927 GKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDN 986
K + L ++TG N +GKS L+ + I+AQ+G IP F R+ R+ +D+
Sbjct: 623 TKHSSSLQIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGSFPVFKRLHARV-CNDS 681
Query: 987 IMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSL 1046
+ S F E+ E LD + +LL++DELGRG S +DGF ++ AV H+ ++
Sbjct: 682 MELTSSNFGFEMKEMAYFLDDINTETLLILDELGRGSSIADGFCVSLAVTEHL-LRTEAT 740
Query: 1047 GFFATHYAALGSSFTNHPNVQPLKM-AILVDEESRNVTF 1084
F +TH+ + + P V L M A+L+++ S + +
Sbjct: 741 VFLSTHFQDIPKIMSKKPAVSHLHMDAVLLNDNSVKMNY 779
>YDL154w [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 901
Score = 118 bits (295), Expect = 6e-26
Identities = 138/628 (21%), Positives = 263/628 (40%), Gaps = 77/628 (12%)
Query: 569 LALDGITLQNLEIFANTYD-GTDRG------SLFKLINRAITPMGKRKLRKWVMHPLLKI 621
+ LD T+ L IF + G D+ S+F+L N+ + +R L+ W+++PL
Sbjct: 247 MVLDENTISALHIFPTAHKLGHDKMMRNGFFSVFELFNQVSSDYARRILKSWLINPLTNK 306
Query: 622 EDINXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXRMLSRVHSCSLKIQYFNKVLCGFE 679
+ I ++++ S + ++KV E
Sbjct: 307 KRIETRYSIIRTLLDKQNAIIFSDLSQSIKRCPDAFGFINQLRSGKSTLGTWSKVASFLE 366
Query: 680 D---ILALVEKLSIFADLKGSLKSYLTEIP-SSLTTVLEAWSNAFDRNLAVKDGVIVPNR 735
I LV L + +D L ++ S+L L D + + + N
Sbjct: 367 KGIAIFQLVSSLKLGSDEANILHDIKNKVDISALKECLRKVETVIDFDTSRDTKTLTINT 426
Query: 736 GVEPEFDESMD---RIQGI------EDQL--------QECLTQYKKLLKSSNIQFKDSGK 778
GV+ DE + ++GI E Q+ ++C T K L K N +
Sbjct: 427 GVDNRLDECRNIYNHLEGILLDVARETQIFLLNTMPQEDCKTT-KSLEKLVNAVYIPQLG 485
Query: 779 EIYTIEVPMAATRN-VPH-EWTQMAANKSFKRYYSADVQRLARQMAEAREMHKVLEDDLK 836
+ TI V M + +P+ +W ++ + + + V L + E ++
Sbjct: 486 YLVTISVLMEPLLDGIPNLQWEEIFRSSENIYFKNGRVLELDETYGDIYGAISDFEIEIL 545
Query: 837 NRLYKKFTNHYNAVWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLN 896
L ++ + I +S ++ ++S A+ S + P+LVE E +N
Sbjct: 546 FSLQEQILRRKTQLTAYNI-LLSELEILLSFAQVSAERNY--AEPQLVED--ECILEIIN 600
Query: 897 GYIRFKELRHPCFNMGSSSAKEFIPNDVVLG-----------KDAPQLGLLTGANAAGKS 945
G RH + + +IPN ++ ++ ++ ++TGANA+GKS
Sbjct: 601 G-------RHALYE---TFLDNYIPNSTMIDGGLFSELSWCEQNKGRIIVVTGANASGKS 650
Query: 946 TVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKIL 1005
L + V LAQ+GC++P E A D+I+TR+ + + + +S+F ++ + K L
Sbjct: 651 VYLTQNGLIVYLAQIGCFVPAERARIGIADKILTRIRTQETVYKTQSSFLLDSQQMAKSL 710
Query: 1006 DLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHHVATHIQSLGFFA-THYAALGSSFTNHP 1064
L T +SL+++DE G+G DG ++ +++ +++ + A TH+ L +
Sbjct: 711 SLATEKSLILIDEYGKGTDILDGPSLFGSIMLNMSKSEKCPRIIACTHFHELFNENVLTE 770
Query: 1065 NVQPLK---MAILV--------------DEESRNVTFLYKLVDGKSDGSFGMHVASMCGI 1107
N++ +K IL+ D ES +TFL+K+ +G S SFG++ A +CG+
Sbjct: 771 NIKGIKHYCTDILISQKYNLLETAHVGEDHESEGITFLFKVKEGISKQSFGIYCAKVCGL 830
Query: 1108 PRSVVDNASIAAENLEHTSKLIKERKNL 1135
R +V+ A + + ++++ NL
Sbjct: 831 SRDIVERAEELSRMINRGDDVVQQCGNL 858
>Hs4505251 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 936
Score = 117 bits (293), Expect = 1e-25
Identities = 114/462 (24%), Positives = 215/462 (45%), Gaps = 59/462 (12%)
Query: 741 FDESMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQM 800
+ E +D I G+ QL E +Y L++S + ++ T + + + + +P E+ ++
Sbjct: 505 YTEIVDDIAGMISQLGE---KYSLPLRTSLSSVRGFFIQMTTDCIALPSDQ-LPSEFIKI 560
Query: 801 AANKSFKRYYSADV----QRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQ 856
+ K+ + SAD+ +R + E M ++ L + +Y+ H + ++ +
Sbjct: 561 SKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYE----HIHCLYKLS-D 615
Query: 857 AISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSA 916
+S +D ++S A AC L + + PE + L K+ HP SA
Sbjct: 616 TVSMLDMLLSFAH--------ACT--LSDYVRPEFTDTL----AIKQGWHPILE--KISA 659
Query: 917 KEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDR 976
++ I N+ + + + L ++TG N +GKST L+ + I+AQ+G Y+P E + F +
Sbjct: 660 EKPIANNTYVTEGSNFL-IITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQ 718
Query: 977 IMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVL 1036
I TR+ D+I STF E+ E IL ++SL+++DELGRG ++ +G I AV
Sbjct: 719 IFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVC 778
Query: 1037 HHVATHIQSLGFFATHYAALGSSFTNHPNVQPLKMAIL-VDEESRN---VTFLYKLVDG- 1091
++ + +++ FATH+ L +PNV+ + + V SRN + + YKL G
Sbjct: 779 EYLLS-LKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGL 837
Query: 1092 KSDGSFGMHVASMCGIPRSVVDNASIAA--------ENLEHTSKLIKERKNLHQSINPVP 1143
+ ++G+ A + +P S+V +A +N T ++ ++R H + V
Sbjct: 838 TEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQ 897
Query: 1144 LGLQSDVVRLVYGDGLTNSKGGTGEGVRVYDNNIKSNVLKSF 1185
S + + +R+Y +N+K + F
Sbjct: 898 TARNSQL---------------DPDSLRIYLSNLKKKYKEDF 924
Score = 58.9 bits (141), Expect = 5e-08
Identities = 56/206 (27%), Positives = 93/206 (44%), Gaps = 15/206 (7%)
Query: 424 GFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPE 483
G A+ID I L +F D+ +++ T + P E+IM + C++ F E
Sbjct: 172 GMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNT-ACAVGNSTKLFTLITE 230
Query: 484 AI--INQRTSKEFYDFEKTFDELITHEYFKSM--DRWPTVLKSYYETGKKVGFHAFGGLL 539
+N T + Y F+E EY + + + TVL K A LL
Sbjct: 231 NFKNVNFTTIQRKY-----FNETKGLEYIEQLCIAEFSTVLMEVQS--KYYCLAAVAALL 283
Query: 540 SYLQWLKLDTSLVTMGQVEEYNPVRSQTCLALDGITLQNLEIFANTYDGTDRGSLFKLIN 599
Y+++++ S+ ++ QT + +D + QNLE+ N D + +LF ++N
Sbjct: 284 KYVEFIQ--NSVYAPKSLKICFQGSEQTAM-IDSSSAQNLELLINNQDYRNNHTLFGVLN 340
Query: 600 RAITPMGKRKLRKWVMHPLLKIEDIN 625
TP G R+LR ++ PL+ IE IN
Sbjct: 341 YTKTPGGSRRLRSNILEPLVDIETIN 366
>Hs20535615 [L] KOG0220 Mismatch repair ATPase MSH4 (MutS family)
Length = 936
Score = 117 bits (292), Expect = 1e-25
Identities = 114/462 (24%), Positives = 215/462 (45%), Gaps = 59/462 (12%)
Query: 741 FDESMDRIQGIEDQLQECLTQYKKLLKSSNIQFKDSGKEIYTIEVPMAATRNVPHEWTQM 800
+ E +D I G+ QL E +Y L++S + ++ T + + + + +P E+ ++
Sbjct: 505 YTEIVDDIAGMISQLGE---KYSLPLRTSFSSARGFFIQMTTDCIALPSDQ-LPSEFIKI 560
Query: 801 AANKSFKRYYSADV----QRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNAVWLPTIQ 856
+ K+ + SAD+ +R + E M ++ L + +Y+ H + ++ +
Sbjct: 561 SKVKNSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYE----HIHCLYKLS-D 615
Query: 857 AISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFKELRHPCFNMGSSSA 916
+S +D ++S A AC L + + PE + L K+ HP SA
Sbjct: 616 TVSMLDMLLSFAH--------ACT--LSDYVRPEFTDTL----AIKQGWHPILE--KISA 659
Query: 917 KEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDR 976
++ I N+ + + + L ++TG N +GKST L+ + I+AQ+G Y+P E + F +
Sbjct: 660 EKPIANNTYVTEGSNFL-IITGPNMSGKSTYLKQIALCQIMAQIGSYVPAEYSSFRIAKQ 718
Query: 977 IMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVL 1036
I TR+ D+I STF E+ E IL ++SL+++DELGRG ++ +G I AV
Sbjct: 719 IFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGTNTEEGIGICYAVC 778
Query: 1037 HHVATHIQSLGFFATHYAALGSSFTNHPNVQPLKMAIL-VDEESRN---VTFLYKLVDG- 1091
++ + +++ FATH+ L +PNV+ + + V SRN + + YKL G
Sbjct: 779 EYLLS-LKAFTLFATHFLELCHIDALYPNVENMHFEVQHVKNTSRNKEAILYTYKLSKGL 837
Query: 1092 KSDGSFGMHVASMCGIPRSVVDNASIAA--------ENLEHTSKLIKERKNLHQSINPVP 1143
+ ++G+ A + +P S+V +A +N T ++ ++R H + V
Sbjct: 838 TEEKNYGLKAAEVSSLPPSIVLDAKEITTQITRQILQNQRSTPEMERQRAVYHLATRLVQ 897
Query: 1144 LGLQSDVVRLVYGDGLTNSKGGTGEGVRVYDNNIKSNVLKSF 1185
S + + +R+Y +N+K + F
Sbjct: 898 TARNSQL---------------DPDSLRIYLSNLKKKYKEDF 924
Score = 58.9 bits (141), Expect = 5e-08
Identities = 56/206 (27%), Positives = 93/206 (44%), Gaps = 15/206 (7%)
Query: 424 GFAAIDTATGHIDLLEFEDDEECSQLDTIMSQFKPTEVIMEKSNVCSLAQKIIKFNAQPE 483
G A+ID I L +F D+ +++ T + P E+IM + C++ F E
Sbjct: 172 GMASIDLKNPQIILSQFADNTTYAKVITKLKILSPLEIIMSNT-ACAVGNSTKLFTLITE 230
Query: 484 AI--INQRTSKEFYDFEKTFDELITHEYFKSM--DRWPTVLKSYYETGKKVGFHAFGGLL 539
+N T + Y F+E EY + + + TVL K A LL
Sbjct: 231 NFKNVNFTTIQRKY-----FNETKGLEYIEQLCIAEFSTVLMEVQS--KYYCLAAVAALL 283
Query: 540 SYLQWLKLDTSLVTMGQVEEYNPVRSQTCLALDGITLQNLEIFANTYDGTDRGSLFKLIN 599
Y+++++ S+ ++ QT + +D + QNLE+ N D + +LF ++N
Sbjct: 284 KYVEFIQ--NSVYAPKSLKICFQGSEQTAM-IDSSSAQNLELLINNQDYRNNHTLFGVLN 340
Query: 600 RAITPMGKRKLRKWVMHPLLKIEDIN 625
TP G R+LR ++ PL+ IE IN
Sbjct: 341 YTKTPGGSRRLRSNILEPLVDIETIN 366
>At3g24320 [L] KOG0217 Mismatch repair ATPase MSH6 (MutS family)
Length = 1022
Score = 99.0 bits (245), Expect = 4e-20
Identities = 96/328 (29%), Positives = 145/328 (43%), Gaps = 22/328 (6%)
Query: 791 RNVPHEW-TQMAANKSFKRYYSADVQRLARQMAEAREMHKVLEDDLKNRLYKKFTNHYNA 849
+ V EW T + RY+ A AR + RE+ L+ + ++ +
Sbjct: 538 KKVGEEWFTTPKVEIALVRYHEASENAKARVLELLRELSVKLQTKINVLVFA-------S 590
Query: 850 VWLPTIQAISNIDCIISLARTSESLGFPACRPKLVEGLHPETNEKLNGYIRFK--ELRHP 907
+ L +A+ + C + SE P LV E + L+G R K L
Sbjct: 591 MLLVISKALFSHACTVH--NYSEGRRRKWVFPTLVGFSLDEGAKPLDGASRMKLTGLSPY 648
Query: 908 CFNMGSSSAKEFIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCE 967
F++ S +A + N V D L LLTG N GKS++LR C A +L G +P E
Sbjct: 649 WFDVSSGTA---VHNTV----DMQSLFLLTGPNGGGKSSLLRSICAAALLGISGLMVPAE 701
Query: 968 EAEFTPVDRIMTRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSD 1027
A D IM + + D+ + GKS+F VE+SE + I+ T+RSL+++DE+ RG ++
Sbjct: 702 SACIPHFDSIMLHMKSYDSPVDGKSSFQVEMSEIRSIVSQATSRSLVLIDEICRGTETAK 761
Query: 1028 GFAIAEAVLHHVATHIQSLGFFATHYAALGSSFTNHPNVQPLKMAILVDEESRNVTFLYK 1087
G IA +V+ + T LG +TH + S N+ M E T +K
Sbjct: 762 GTCIAGSVVESLDTS-GCLGIVSTHLHGIFSLPLTAKNITYKAMGAENVEGQTKPT--WK 818
Query: 1088 LVDGKSDGSFGMHVASMCGIPRSVVDNA 1115
L DG S A G+P SV+ A
Sbjct: 819 LTDGVCRESLAFETAKREGVPESVIQRA 846
>At3g20475 [L] KOG0221 Mismatch repair ATPase MSH5 (MutS family)
Length = 321
Score = 75.9 bits (185), Expect = 4e-13
Identities = 62/229 (27%), Positives = 106/229 (46%), Gaps = 28/229 (12%)
Query: 919 FIPNDVVLGKDAPQLGLLTGANAAGKSTVLRMTCVAVILAQLGCYIPCEEAEFTPVDRIM 978
FIPND + D ++ ++TG N +GKS ++ + V L+ +G ++P + A DRI
Sbjct: 64 FIPNDTEIN-DNGRIHIITGPNYSGKSIYVKQVALIVFLSHIGSFVPADAATVGLTDRIF 122
Query: 979 TRLGASDNIMQGKSTFFVELSETKKILDLVTNRSLLVVDELGRGGSSSDGFAIAEAVLHH 1038
+G S + +STF ++L + +L T+RSL ++DE G+G + DG + + H
Sbjct: 123 CAMG-SKFMTAEQSTFMIDLHQVGMMLRQATSRSLCLLDEFGKGTLTEDGIGLLGGTISH 181
Query: 1039 VATHIQ-SLGFFATHYAAL--GSSFTNHPNVQPLKMAIL-VDEESRN---VTFLYKLVDG 1091
AT + TH L S ++ M++L D ES N + FLY+
Sbjct: 182 FATCAEPPRVVVCTHLTELLNESCLPVSEKIKFYTMSVLRPDTESANMEEIVFLYR---- 237
Query: 1092 KSDGSFGMHVASMCG----------IPRSVVDNASIAAENLEHTSKLIK 1130
+G+ + S+ +P VV A+I + E + + K
Sbjct: 238 -----YGVSLTSILPKLPTFLRLPCVPEEVVKRAAIVLDAFESNNNVDK 281
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.133 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,550,039
Number of Sequences: 60738
Number of extensions: 2856404
Number of successful extensions: 10096
Number of sequences better than 1.0e-05: 28
Number of HSP's better than 0.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 9940
Number of HSP's gapped (non-prelim): 63
length of query: 1194
length of database: 30,389,216
effective HSP length: 118
effective length of query: 1076
effective length of database: 23,222,132
effective search space: 24987014032
effective search space used: 24987014032
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)