ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4536 good H KOG3199 Coenzyme transport and metabolism Nicotinamide mononucleotide adenylyl transferase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4536 1604557 1603211 -449
(449 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR328w [H] KOG3199 Nicotinamide mononucleotide adenylyl transfe... 525 e-149
YGR010w [H] KOG3199 Nicotinamide mononucleotide adenylyl transfe... 513 e-145
SPAC806.06c [H] KOG3199 Nicotinamide mononucleotide adenylyl tra... 391 e-108
Hs20070321 [H] KOG3199 Nicotinamide mononucleotide adenylyl tran... 204 2e-52
Hs17444692 [H] KOG3199 Nicotinamide mononucleotide adenylyl tran... 131 2e-30
CE09709 [H] KOG3199 Nicotinamide mononucleotide adenylyl transfe... 116 8e-26
7301243 [H] KOG3199 Nicotinamide mononucleotide adenylyl transfe... 112 9e-25
CE19007 [H] KOG3199 Nicotinamide mononucleotide adenylyl transfe... 107 4e-23
Hs22045368 [H] KOG3199 Nicotinamide mononucleotide adenylyl tran... 100 3e-21
At5g55810 [H] KOG3199 Nicotinamide mononucleotide adenylyl trans... 82 2e-15
>YLR328w [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 401
Score = 525 bits (1353), Expect = e-149
Identities = 286/452 (63%), Positives = 321/452 (70%), Gaps = 54/452 (11%)
Query: 1 MDPTRDPNFKSPQELDSEAL---QSSTDIPKIGPIIPYVLADYNTAIDKPIRPRKYKKNA 57
MDPTR P+FK P D E + + IPK PIIPYVLAD N++ID P ++ KK+
Sbjct: 1 MDPTRAPDFKPPSA-DEELIPPPDPESKIPKSIPIIPYVLADANSSIDAPFNIKRKKKHP 59
Query: 58 IKRKLASSMTSTSDDSNEQQHLSANSNNGFIPLKQRELQPVXXXXXXXXXXXXXXXXXXX 117
K + + N+++H IPL Q + QP+
Sbjct: 60 ---KHHHHHHHSRKEGNDKKHQH-------IPLNQDDFQPLSAEVSSE------------ 97
Query: 118 NVDLDIDPNPESDEVMASAPVAHXXXXXXXXXXXXXXXXXXXXLDQEITSRIHKFQIADL 177
D D + S E S T + K+QIADL
Sbjct: 98 ----DDDADFRSKERYGSDSTTESE-----------------------TRGVQKYQIADL 130
Query: 178 EEVPHGIVRQANNWKDYQFPAHRLKQRLRNSNKLPLVIVACGSFSPITYLHLRMFEMALD 237
EEVPHGIVRQA +DY+FP+HRL ++L + NKLPLVIVACGSFSPITYLHLRMFEMALD
Sbjct: 131 EEVPHGIVRQARTLEDYEFPSHRLSKKLLDPNKLPLVIVACGSFSPITYLHLRMFEMALD 190
Query: 238 AISEQTRFEVIGGYYSPVSDNYKKPGLAPAHHRVRMCELGCERTSSWLMVDAWESLQPTY 297
AISEQTRFEVIGGYYSPVSDNY+K GLAP++HRVRMCEL CERTSSWLMVDAWESLQP+Y
Sbjct: 191 AISEQTRFEVIGGYYSPVSDNYQKQGLAPSYHRVRMCELACERTSSWLMVDAWESLQPSY 250
Query: 298 TRTAMVLDHFNEEINVKRKGVIKNDAGERMGVKIMLLAGGDLIESMGEPNVWADYDLHHI 357
TRTA VLDHFN EIN+KR GV GE++GVKIMLLAGGDLIESMGEPNVWAD DLHHI
Sbjct: 251 TRTAKVLDHFNHEINIKRGGV-ATVTGEKIGVKIMLLAGGDLIESMGEPNVWADADLHHI 309
Query: 358 LGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILVIKQLIYNDISSTKVRLFIRRRMSVQ 417
LGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNIL+IKQLIYNDISSTKVRLFIRR MSVQ
Sbjct: 310 LGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRRAMSVQ 369
Query: 418 YLLPNSVIRYIQEHGLYVNQTEPVKQVIGNKD 449
YLLPNSVIRYIQEH LYV+QTEPVKQV+GNK+
Sbjct: 370 YLLPNSVIRYIQEHRLYVDQTEPVKQVLGNKE 401
>YGR010w [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 395
Score = 513 bits (1320), Expect = e-145
Identities = 279/457 (61%), Positives = 326/457 (71%), Gaps = 70/457 (15%)
Query: 1 MDPTRDPNFKSPQELDSEALQSSTD----IPKIGPIIPYVLADYNTAIDKPIRPRKYKKN 56
MDPT+ P+FK PQ +E LQ D IPK GPI+PYVLADYN++ID P YK
Sbjct: 1 MDPTKAPDFKPPQP--NEELQPPPDPTHTIPKSGPIVPYVLADYNSSIDAPFNLDIYKTL 58
Query: 57 AIKRKLASSMTSTSDDSNEQQHLSANSNNGFIPLKQRELQPVXXXXXXXXXXXXXXXXXX 116
+ ++K A+S SN H IPL + QP+
Sbjct: 59 SSRKKNANS-------SNRMDH---------IPLNTSDFQPLSR---------------- 86
Query: 117 XNVDLDIDPNPESDEVMASAPVAHXXXXXXXXXXXXXXXXXXXXLDQEITSR----IHKF 172
+V + + +S+ + A+ Q++T + K
Sbjct: 87 -DVSSEEESEGQSNGIDATL--------------------------QDVTMTGNLGVLKS 119
Query: 173 QIADLEEVPHGIVRQANNWKDYQFPAHRLKQRLRNSNKLPLVIVACGSFSPITYLHLRMF 232
QIADLEEVPH IVRQA +DY+FP HRL ++L++ KLPL+IVACGSFSPITYLHLRMF
Sbjct: 120 QIADLEEVPHTIVRQARTIEDYEFPVHRLTKKLQDPEKLPLIIVACGSFSPITYLHLRMF 179
Query: 233 EMALDAISEQTRFEVIGGYYSPVSDNYKKPGLAPAHHRVRMCELGCERTSSWLMVDAWES 292
EMALD I+EQTRFEV+GGY+SPVSDNY+K GLAPA+HRVRMCEL CERTSSWLMVDAWES
Sbjct: 180 EMALDDINEQTRFEVVGGYFSPVSDNYQKRGLAPAYHRVRMCELACERTSSWLMVDAWES 239
Query: 293 LQPTYTRTAMVLDHFNEEINVKRKGVIKNDAGERMGVKIMLLAGGDLIESMGEPNVWADY 352
LQ +YTRTA VLDHFN EIN+KR G++ D GE+MGVKIMLLAGGDLIESMGEP+VWAD
Sbjct: 240 LQSSYTRTAKVLDHFNHEINIKRGGIMTVD-GEKMGVKIMLLAGGDLIESMGEPHVWADS 298
Query: 353 DLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILVIKQLIYNDISSTKVRLFIRR 412
DLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNIL+IKQLIYNDISSTKVRLFIRR
Sbjct: 299 DLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILIIKQLIYNDISSTKVRLFIRR 358
Query: 413 RMSVQYLLPNSVIRYIQEHGLYVNQTEPVKQVIGNKD 449
MSVQYLLPNSVIRYIQE+ LY+NQ+EPVKQV+ +K+
Sbjct: 359 GMSVQYLLPNSVIRYIQEYNLYINQSEPVKQVLDSKE 395
>SPAC806.06c [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 365
Score = 391 bits (1005), Expect = e-108
Identities = 192/272 (70%), Positives = 222/272 (81%), Gaps = 2/272 (0%)
Query: 173 QIADLEEVPHGIVRQANNWKDYQFPAHRLKQRLRNSNKLPLVIVACGSFSPITYLHLRMF 232
++ DLEEVP GI RQA +Y FP HR + L + K+PLV+VACGSFSPITYLHLRMF
Sbjct: 85 EVMDLEEVPRGITRQARQLNEYIFPKHRFRNHLVDEGKIPLVLVACGSFSPITYLHLRMF 144
Query: 233 EMALDAISEQTRFEVIGGYYSPVSDNYKKPGLAPAHHRVRMCELGCERTSSWLMVDAWES 292
EMA D I EQT E++ GY+SPV+D+YKK GLAPA+HRVRMCEL CERTSSWLMVDAWES
Sbjct: 145 EMATDTIQEQTNMELVAGYFSPVNDHYKKEGLAPAYHRVRMCELACERTSSWLMVDAWES 204
Query: 293 LQPTYTRTAMVLDHFNEEINVKRKGVIKNDAGERMGVKIMLLAGGDLIESMGEPNVWADY 352
LQP+YT TA VLDHF+EEIN KR G+ +D G + KIMLLAGGDLI SMGEP VW+D
Sbjct: 205 LQPSYTCTARVLDHFDEEINQKRGGITLSD-GTKRPCKIMLLAGGDLIASMGEPGVWSDK 263
Query: 353 DLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILVIKQLIYNDISSTKVRLFIRR 412
DLHHILG +GC IVERTGSDV +FLL+HDIM+ +R NILVIKQLIYNDISSTKVRLFIRR
Sbjct: 264 DLHHILGKFGCCIVERTGSDVWAFLLAHDIMFAYRGNILVIKQLIYNDISSTKVRLFIRR 323
Query: 413 RMSVQYLLPNSVIRYIQEHGLYVNQTEPVKQV 444
MS++YLLPNSVI+YI+ + LY EPVK +
Sbjct: 324 GMSIRYLLPNSVIQYIERYALY-RDAEPVKTI 354
>Hs20070321 [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 279
Score = 204 bits (520), Expect = 2e-52
Identities = 106/260 (40%), Positives = 154/260 (58%), Gaps = 26/260 (10%)
Query: 205 LRNSNKLPLVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYKKPGL 264
+ NS K +V++ACGSF+PIT +HLR+FE+A D ++ R+ V+ G SPV D YKK GL
Sbjct: 1 MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGRYTVVKGIISPVGDAYKKKGL 60
Query: 265 APAHHRVRMCELGCERTSSWLMVDAWESLQPTYTRTAMVLDHFNEEINV----------- 313
PA+HRV M EL + S W+ VD WESLQ + T VL H E++
Sbjct: 61 IPAYHRVIMAELAT-KNSKWVEVDTWESLQKEWKETLKVLRHHQEKLEASDCDHQQNSPT 119
Query: 314 ------KRKGVIKNDAGERMGV--------KIMLLAGGDLIESMGEPNVWADYDLHHILG 359
KRK D+ ++ + K+ LL G DL+ES PN+W D+ I+
Sbjct: 120 LERPGRKRKWTETQDSSQKKSLEPKTKAVPKVKLLCGADLLESFAVPNLWKSEDITQIVA 179
Query: 360 NYGCLIVERTGSDVRSFLLSHDIMYEHRRNILVIKQLIYNDISSTKVRLFIRRRMSVQYL 419
NYG + V R G+D + F+ D++++HR NI V+ + I NDISSTK+R +RR S++YL
Sbjct: 180 NYGLICVTRAGNDAQKFIYESDVLWKHRSNIHVVNEWIANDISSTKIRRALRRGQSIRYL 239
Query: 420 LPNSVIRYIQEHGLYVNQTE 439
+P+ V YI++H LY +++E
Sbjct: 240 VPDLVQEYIEKHNLYSSESE 259
>Hs17444692 [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 218
Score = 131 bits (330), Expect = 2e-30
Identities = 76/220 (34%), Positives = 116/220 (52%), Gaps = 29/220 (13%)
Query: 220 SFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYKKPGLAPAHHRVRMCELGCE 279
SF+PIT HLR+FE+A D ++ R+ V+ PV D YKK GL PAHH+ + G E
Sbjct: 17 SFNPITNRHLRLFELAKDYMNGTGRYRVVKHMIFPVGDAYKKKGLIPAHHQKGLDGRGRE 76
Query: 280 RTSSWLMVDAWESLQPTYTRTAMVLDHFNEEINVKRKGVIKNDAGERMGVKIMLLAGGDL 339
+++ +SL+P K KG K+ LL G DL
Sbjct: 77 LNKDKILLKK-KSLEP------------------KPKG----------ASKVKLLCGADL 107
Query: 340 IESMGEPNVWADYDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILVIKQLIYN 399
+E G PN+W ++ + +YG L + +D F+ +++++H NI V+ + I N
Sbjct: 108 LECFGVPNLWKGENITQTVADYGLLCITWAANDAHKFIYDSNVLWKHHSNIHVVNEWITN 167
Query: 400 DISSTKVRLFIRRRMSVQYLLPNSVIRYIQEHGLYVNQTE 439
DISSTK++ +RR SV YLLP+ YI++H LY +++E
Sbjct: 168 DISSTKIQRALRRGQSVHYLLPDLFQEYIEKHNLYSSESE 207
>CE09709 [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 223
Score = 116 bits (290), Expect = 8e-26
Identities = 73/229 (31%), Positives = 125/229 (53%), Gaps = 19/229 (8%)
Query: 213 LVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYK-KPGLAPAHHRV 271
+ ++A GSF+P T HLRM E+A + E +V+ G SPV+D+Y KP L ++ R+
Sbjct: 4 VALLAVGSFNPPTIAHLRMLEVARSHL-ETINTQVVEGIMSPVADSYNNKPTLIKSNFRI 62
Query: 272 RMCELGCERTSSWLMVDAWESLQPTYTRTAMVLDHFNEEINVKRKGVIKNDAGERMGVKI 331
+M ++S W+ D WE + T+TRT VL H E + K +D G +
Sbjct: 63 QMVR-AATKSSDWIRADDWECTRTTWTRTIDVLRHHRELVQEK----FGSDVG------M 111
Query: 332 MLLAGGDLIESMGE-----PNVWADYDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEH 386
ML+ GGD+++S N+W D+ I+ +G +++ R GS+ + + S + E
Sbjct: 112 MLVVGGDVVDSFTRILPDGSNLWNSSDIRTIITEFGLIVLSREGSNPLNTIQSMPAISEF 171
Query: 387 RRNILVIK-QLIYNDISSTKVRLFIRRRMSVQYLLPNSVIRYIQEHGLY 434
I+ +K ++ + +SST++R I + S++Y P+ VI +I+E+ LY
Sbjct: 172 CDRIIQVKDEVCPSGVSSTRLRAAIMNKKSIKYSTPDEVINFIRENNLY 220
>7301243 [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 236
Score = 112 bits (281), Expect = 9e-25
Identities = 71/206 (34%), Positives = 105/206 (50%), Gaps = 21/206 (10%)
Query: 242 QTRFEVIGGYYSPVSDNYKKPGLAPAHHRVRMCELGCERTSSWLMVDAWESLQPTYTRTA 301
Q V+GG SP D+Y K GLA A R M +L + +S+W+ + WE Q + RT
Sbjct: 2 QGTHRVVGGIISPTHDSYGKKGLASALDRCAMVKLATQ-SSNWIRLSDWEVHQNQWMRTQ 60
Query: 302 MVLDHFNEEINVK-RKGVIKNDAGE---------------RMGVKIMLLAGGDLIESMGE 345
VL H IN G D GE R V + LL G DL+ES
Sbjct: 61 AVLQHHQNYINNHINSGGGGGDDGENTHLPGWLPRGLHDSRDPVHLKLLCGADLLESFAV 120
Query: 346 PNVWADYDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILVIKQLIYNDISSTK 405
P +WA+ D+ I+ N+G +++ R GS+ F+ DI+ +++ NI +I + N++SST
Sbjct: 121 PGLWAEADIEDIVANHGLVVITRAGSNPGKFIFDSDILTKYQSNITLITNWVPNEVSSTL 180
Query: 406 VRLFIRRRMSVQYLL----PNSVIRY 427
+R + R SV+YLL P+S R+
Sbjct: 181 IRRLLGRGQSVKYLLDDLKPSSPTRF 206
>CE19007 [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 218
Score = 107 bits (267), Expect = 4e-23
Identities = 77/228 (33%), Positives = 112/228 (48%), Gaps = 22/228 (9%)
Query: 213 LVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYKKPGLAPAHHRVR 272
+VI+A GSF+P T HL M E A ++ + + V+ G SPVSD Y K L A HR+
Sbjct: 6 VVILAVGSFNPPTNGHLCMMEDAKYSLEKSGKI-VLEGIMSPVSDGYAKKSLISAKHRLA 64
Query: 273 MCELGCERTSSWLMVDAWESLQPTYTRTAMVLDHFNEEINVKRKGVIKNDAGERMGVKIM 332
E S W+ WE Q +T T VL H ++ N G V ++
Sbjct: 65 QTE-AATYDSDWIHASGWECAQSEWTATVNVLKHHQQD----------NKLGS--DVNVL 111
Query: 333 LLAGGDLIESM------GEPNVWADYDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEH 386
LL GGD+IES G P VW D+ I+ + G ++ R GSD L ++
Sbjct: 112 LLFGGDVIESFDKFYADGTP-VWDREDVEEII-SAGIVVRSRPGSDPEQTLKKLNLNENS 169
Query: 387 RRNILVIKQLIYNDISSTKVRLFIRRRMSVQYLLPNSVIRYIQEHGLY 434
+ + + N ISST +R ++ S++Y P+SVI+YI++H LY
Sbjct: 170 DKVHFIKNAISSNSISSTSLRAALKEHRSIKYTTPDSVIKYIKDHRLY 217
>Hs22045368 [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 265
Score = 100 bits (250), Expect = 3e-21
Identities = 50/107 (46%), Positives = 66/107 (60%), Gaps = 1/107 (0%)
Query: 205 LRNSNKLPLVIVACGSFSPITYLHLRMFEMALDAISEQTRFEVIGGYYSPVSDNYKKPGL 264
+ NS K + + ACGSF+ IT HLR+FE+A D ++ R+ V+ G SPV D YKK GL
Sbjct: 1 MENSEKTEVALCACGSFNSITNKHLRLFELAKDYMNGTGRYRVVKGIISPVGDAYKKKGL 60
Query: 265 APAHHRVRMCELGCERTSSWLMVDAWESLQPTYTRTAMVLDHFNEEI 311
PAHH+V EL + S W+ VD WESLQ + T VL H E++
Sbjct: 61 IPAHHQVITAELATQ-NSKWVEVDTWESLQKEWIETVKVLRHHQEKL 106
>At5g55810 [H] KOG3199 Nicotinamide mononucleotide adenylyl transferase
Length = 242
Score = 82.0 bits (201), Expect = 2e-15
Identities = 61/217 (28%), Positives = 100/217 (45%), Gaps = 28/217 (12%)
Query: 245 FEVIGGYYSPVSDNYKKP----GLAPAHHRVRMCELGCERT-----SSWLMVDAWESLQP 295
F V+GGY SPV+D YKK + V G + ++ + + +
Sbjct: 31 FHVLGGYMSPVNDAYKKKFSLVEQCVVYKNVEAVSTGISKQLPTNFDGFIKGQDFLNNKS 90
Query: 296 TYTRTA---MVLDHFNEEINVKRKGVIKNDAGERMGVKIMLLAGGDLIESMGEPNVWADY 352
T TR + + + N K K ++ ++ +K+MLL G DL+ S P VW
Sbjct: 91 TCTRGVACYVFIIRASHYANDKHKFILMLES-----LKVMLLCGSDLLLSFCTPGVWIPE 145
Query: 353 DL-----------HHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNILVIKQLIYNDI 401
L I +YG + + R G DV + + +I+ E+ N+ ++ + N I
Sbjct: 146 QLCSFFNTWFLKLRTICKDYGIVCIRREGQDVENMISGDEILNENCANVKIVDNTVPNQI 205
Query: 402 SSTKVRLFIRRRMSVQYLLPNSVIRYIQEHGLYVNQT 438
SS+++R I R +SV+YL + VI YI++H LY T
Sbjct: 206 SSSRLRQCISRGLSVKYLTEDGVIDYIRQHQLYTELT 242
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,304,119
Number of Sequences: 60738
Number of extensions: 995592
Number of successful extensions: 2375
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 2345
Number of HSP's gapped (non-prelim): 14
length of query: 449
length of database: 30,389,216
effective HSP length: 110
effective length of query: 339
effective length of database: 23,708,036
effective search space: 8037024204
effective search space used: 8037024204
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)