ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII4792 good F KOG2584 Nucleotide transport and metabolism Dihydroorotase and related enzymes
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII4792 1698556 1696928 -543
(543 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
7296723 [F] KOG2584 Dihydroorotase and related enzymes 217 4e-56
At5g12200 [F] KOG2584 Dihydroorotase and related enzymes 207 2e-53
Hs19923821 [F] KOG2584 Dihydroorotase and related enzymes 204 4e-52
Hs4503375 [F] KOG2584 Dihydroorotase and related enzymes 198 2e-50
CE05452 [F] KOG2584 Dihydroorotase and related enzymes 198 2e-50
Hs4503377 [F] KOG2584 Dihydroorotase and related enzymes 192 1e-48
Hs4503051 [F] KOG2584 Dihydroorotase and related enzymes 189 1e-47
Hs4503379 [F] KOG2584 Dihydroorotase and related enzymes 187 3e-47
Hs11321617 [F] KOG2584 Dihydroorotase and related enzymes 186 8e-47
CE28484 [F] KOG2584 Dihydroorotase and related enzymes 182 1e-45
7296724 [F] KOG2584 Dihydroorotase and related enzymes 121 3e-27
CE26069 [F] KOG2584 Dihydroorotase and related enzymes 102 1e-21
YIR027c [F] KOG2584 Dihydroorotase and related enzymes 100 7e-21
7293258 [R] KOG0370 Multifunctional pyrimidine synthesis protein... 73 1e-12
Hs18105007 [R] KOG0370 Multifunctional pyrimidine synthesis prot... 61 5e-09
CE03105 [R] KOG0370 Multifunctional pyrimidine synthesis protein... 57 5e-08
>7296723 [F] KOG2584 Dihydroorotase and related enzymes
Length = 589
Score = 217 bits (552), Expect = 4e-56
Identities = 161/512 (31%), Positives = 243/512 (47%), Gaps = 67/512 (13%)
Query: 8 IKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEV--IDAEGAYVTPGGIDAHVHV 65
IKNG +V + AD+ I +G + VG + + V IDA G + PGGID H H+
Sbjct: 24 IKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHTHM 83
Query: 66 DEPLKLLGPVA-DTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYETQ 124
P G VA D T +AVAGGTT +I F +K ++ EA D ++ +
Sbjct: 84 QLPFG--GAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAY-DKWRS----WADP 136
Query: 125 KLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL-QISDYDIL 183
K+ CDY LH+ + +K + ++ + + GV S K FM Y GL Q++D D+L
Sbjct: 137 KVCCDYGLHVGITW-------WSKSVSEEIGILCKELGVNSFKTFMAYKGLYQLNDSDLL 189
Query: 184 TTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRAIVL 243
+ R MVHAENGD++ ++L + + P H +SRP VE EA +RA VL
Sbjct: 190 DVFERIRHLNGVAMVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVL 249
Query: 244 AKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQQST 303
A M TP+ ++S + + + A+ G V+ ET
Sbjct: 250 AHQMKTPLFVSGLTSKSSAELVGRARRSGYCVFGET-----------------------L 286
Query: 304 CSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPE-HCQESVWKAMNNGTFTIVGSDHC 362
S +S ++A D+ AI SPPIR + K++ + GSD+C
Sbjct: 287 ASSLGRS-----MSAVPKGDRIY---AITSPPIRESAETPRQLMKSLAYDDLQLTGSDNC 338
Query: 363 AYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFVELQ 422
+N K GK G+F IPNG+ GV RM L+++ GV G L + +FV +
Sbjct: 339 TFNKEHKALGK---------GDFTKIPNGVNGVEDRMSLVWEKGVHAG-LLDPCRFVAVT 388
Query: 423 CTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPYEGF 482
TN AK++ +YP+KG I G SDAD+V+W T++ D H CD+ +EG
Sbjct: 389 STNAAKIFNIYPQKGRIAVG-SDADIVIW------NPNATRTISKDTHHHACDFNIFEGM 441
Query: 483 EINNWPRFTIVKGSIVYKEGEIIKENAKGTYV 514
++ F +V+G I + G + G ++
Sbjct: 442 TVHGVCEFVLVRGRICAERGNVRVAEGFGRFI 473
>At5g12200 [F] KOG2584 Dihydroorotase and related enzymes
Length = 531
Score = 207 bits (528), Expect = 2e-53
Identities = 158/519 (30%), Positives = 248/519 (47%), Gaps = 67/519 (12%)
Query: 1 MSTYDLLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGID 60
+S+ +LIK GTVV A AD+ + NG ++ V ++ V+DA G +V PGGID
Sbjct: 42 VSSTRILIKGGTVVNAHHQELADVYVENGIIVAVQPNIKVGDEVTVLDATGKFVMPGGID 101
Query: 61 AHVHVDEPLKLLGP-VADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIE 119
H H+ ++ +G D +A+AGGTT I F ++ ++ A E
Sbjct: 102 PHTHL--AMEFMGTETIDDFFSGQAAALAGGTTMHIDFVIP---------VNGNLVAGFE 150
Query: 120 LYE--TQKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPG-LQ 176
YE +++ DY H+ + ++ + + + + G+ S K F+ Y G L
Sbjct: 151 AYENKSRESCMDYGFHMAITKWDEG-------VSRDMEMLVKEKGINSFKFFLAYKGSLM 203
Query: 177 ISDYDILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEA 236
++D +L ++ + G MVHAENGD V +++ E +T P H +SRP ++EGEA
Sbjct: 204 VTDDLLLEGLKRCKSLGALAMVHAENGDAVFEGQKRMIELGITGPEGHALSRPPVLEGEA 263
Query: 237 TNRAIVLAKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHE 296
T RAI LA+ ++TP+ VHV S +A+D I A+ G KV E +L D H
Sbjct: 264 TARAIRLARFINTPLYVVHVMSVDAMDEIAKARKSGQKVIGEPVVSGLILDD------HW 317
Query: 297 LEQQQSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPEHCQESVWKAMNNGTFTI 356
L T I +K + SPPIRP +++ A++ G +
Sbjct: 318 LWDPDFT----------------------IASKYVMSPPIRPVGHGKALQDALSTGILQL 355
Query: 357 VGSDHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMT 416
VG+DHC +N K G LD +F+ IPNG+ G+ RM L++D V G+L + T
Sbjct: 356 VGTDHCTFNSTQKALG-LD--------DFRRIPNGVNGLEERMHLIWDTMVESGQL-SAT 405
Query: 417 KFVELQCTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDY 476
+V + T A+++ +YP+KG+IL G SDAD+++ + D
Sbjct: 406 DYVRITSTECARIFNIYPRKGAILAG-SDADIIILNPNSSYEISSKSHHSRS------DT 458
Query: 477 TPYEGFEINNWPRFTIVKGSIVYKEGEIIKENAKGTYVK 515
YEG TI G IV++ E+ G Y++
Sbjct: 459 NVYEGRRGKGKVEVTIAGGRIVWENEELKVVPRSGKYIE 497
>Hs19923821 [F] KOG2584 Dihydroorotase and related enzymes
Length = 564
Score = 204 bits (518), Expect = 4e-52
Identities = 159/511 (31%), Positives = 240/511 (46%), Gaps = 62/511 (12%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHV 65
+LIK G VV + AD+ I NG + VG++L +VIDA G V PGGID H
Sbjct: 10 ILIKGGKVVNDDCTHEADVYIENGIIQQVGRELMIPGGAKVIDATGKLVIPGGIDTSTHF 69
Query: 66 DEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYETQK 125
+ + D T +A+ GGTT +I DK + L D+ + L + K
Sbjct: 70 HQTF-MNATCVDDFYHGTKAALVGGTTMIIGHVLPDKETS----LVDAYEKCRGLADP-K 123
Query: 126 LYCDYALHL-ILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL-QISDYDIL 183
+ CDYALH+ I + K + +++ ++ GV S ++FMTY L + D ++
Sbjct: 124 VCCDYALHVGITWWAPK--------VKAEMETLVREKGVNSFQMFMTYKDLYMLRDSELY 175
Query: 184 TTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRAIVL 243
+ A + G VHAENG++V ++ + +T P +SRP +E EAT+R I +
Sbjct: 176 QVLHACKDIGAIARVHAENGELVAEGAKEALDLGITGPEGIEISRPEELEAEATHRVITI 235
Query: 244 AKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQQST 303
A PI V+VSS A D I +A+ +G V AET +A L+ + H Q S
Sbjct: 236 ANRTHCPIYLVNVSSISAGDVIAAAKMQGKVVLAETTTAHATLTGL-----HYYHQDWSH 290
Query: 304 CSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPE-HCQESVWKAMNNGTFTIVGSDHC 362
A + PP+R + + + + N T IV SDH
Sbjct: 291 -----------------------AAAYVTVPPLRLDTNTSTYLMSLLANDTLNIVASDHR 327
Query: 363 AYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFVELQ 422
+ K GK D F IP+G+ GV RM ++++ GV+ GK+ + +FV +
Sbjct: 328 PFTTKQKAMGKED---------FTKIPHGVSGVQDRMSVIWERGVVGGKM-DENRFVAVT 377
Query: 423 CTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPYEGF 482
+N AKL LYP+KG I+PG +DAD+VVW T++ V G D+ YE
Sbjct: 378 SSNAAKLLNLYPRKGRIIPG-ADADVVVW------DPEATKTISASTQVQGGDFNLYENM 430
Query: 483 EINNWPRFTIVKGSIVYKEGEIIKENAKGTY 513
+ P TI +G +VY+ G + G +
Sbjct: 431 RCHGVPLVTISRGRVVYENGVFMCAEGTGKF 461
>Hs4503375 [F] KOG2584 Dihydroorotase and related enzymes
Length = 519
Score = 198 bits (504), Expect = 2e-50
Identities = 149/517 (28%), Positives = 233/517 (44%), Gaps = 64/517 (12%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDL----DTALAEEVIDAEGAYVTPGGIDA 61
LLI+ G VV AD+ + +G V +G DL V+DA G V PGGID
Sbjct: 7 LLIRGGRVVNDDFSEVADVLVEDGVVRALGHDLLPPGGAPAGLRVLDAAGKLVLPGGIDT 66
Query: 62 HVHVDEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELY 121
H H+ P + D + T +A++GGTT +I FA K + EA +
Sbjct: 67 HTHMQFPFMGSRSI-DDFHQGTKAALSGGTTMIIDFAIPQKGGSLIEAFETW-----RSW 120
Query: 122 ETQKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL-QISDY 180
K+ CDY+LH+ + + + ++ + ++ GV S K+FM Y L ++D
Sbjct: 121 ADPKVCCDYSLHVAVTW-------WSDQVKEEMKILVQDKGVNSFKMFMAYKDLYMVTDL 173
Query: 181 DILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRA 240
++ ++ G VHAENGD++ +++ +T P H + RP VE EAT RA
Sbjct: 174 ELYEAFSRCKEIGAIAQVHAENGDLIAEGAKKMLALGITGPEGHELCRPEAVEAEATLRA 233
Query: 241 IVLAKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQ 300
I +A ++ P+ VHV S A I A+ G VY E + + + T H ++
Sbjct: 234 ITIASAVNCPLYIVHVMSKSAAKVIADARRDGKVVYGE-----PIAASLGTDGTHYWNKE 288
Query: 301 QSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPE-HCQESVWKAMNNGTFTIVGS 359
A + PP+RP+ + + + N T G+
Sbjct: 289 WHH-----------------------AAHHVMGPPLRPDPSTPDFLMNLLANDDLTTTGT 325
Query: 360 DHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFV 419
D+C +N K GK D F IPNG+ GV RM ++++ GV GK+ + +FV
Sbjct: 326 DNCTFNTCQKALGKDD---------FTKIPNGVNGVEDRMSVIWEKGVHSGKM-DENRFV 375
Query: 420 ELQCTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPY 479
+ TN AK++ LYP+KG I G SDAD+V+W T++ ++ +
Sbjct: 376 AVTSTNAAKIFNLYPRKGRIAVG-SDADIVIW------DPKGTRTISAKTHHQAVNFNIF 428
Query: 480 EGFEINNWPRFTIVKGSIVYKEGEIIKENAKGTYVKR 516
EG + P TI +G +VY+ G G ++ R
Sbjct: 429 EGMVCHGVPLVTISRGKVVYEAGVFSVTAGDGKFIPR 465
>CE05452 [F] KOG2584 Dihydroorotase and related enzymes
Length = 520
Score = 198 bits (504), Expect = 2e-50
Identities = 150/512 (29%), Positives = 232/512 (45%), Gaps = 61/512 (11%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHV 65
LLIKNGT+V I+ +D+ + +G+++ + + EV+DA V PGGID H H+
Sbjct: 3 LLIKNGTIVNDDAIFKSDVLVLDGRIVEIAPSIQPTPGLEVVDATDRLVIPGGIDPHTHM 62
Query: 66 DEPLKLLGPVA-DTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYETQ 124
P +G +A D T +AVAGGTT +I F K ++ A D + +
Sbjct: 63 QLPF--MGEIAKDDFHRGTEAAVAGGTTMIIDFVIPTKGESLLVAY-DRWRG----WADP 115
Query: 125 KLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL-QISDYDIL 183
K+ CDY L + + + G ++ YG+ S K F+ Y G+ + D +
Sbjct: 116 KVVCDYGLSMAI------TSWGPEIAKEMEIVTGAEYGINSFKFFLAYAGVFMVRDEEFY 169
Query: 184 TTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRAIVL 243
M K VHAENG ++ E L +T P H SRP +E EAT RA +
Sbjct: 170 QGMIQCAKLRALARVHAENGSVIAERCEHLLSSGITGPEGHTQSRPEELEAEATFRACTM 229
Query: 244 AKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQQST 303
A + P+ VHV S A I + KG V+ E P A L+ + ++E
Sbjct: 230 ASQANCPLYVVHVMSKGAAAAIAHHRKKGAVVFGE--PIAAGLATDGSHYYNE------- 280
Query: 304 CSDANKSEPRVKLTAKEIDDKFIGAKAICSPPI-RPEHCQESVWKAMNNGTFTIVGSDHC 362
D A+ + SPP+ R ++ K + G + +D+C
Sbjct: 281 -------------------DWLHAARYVMSPPLSRDPSTPSALMKLLAAGELHLTATDNC 321
Query: 363 AYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFVELQ 422
++ K+ GK D F IPNG+ GV RM +++D GV G + M +FV +
Sbjct: 322 TFDCQQKSLGKDD---------FTKIPNGVNGVEDRMSVVWDKGVHAGIIDPM-RFVAVT 371
Query: 423 CTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPYEGF 482
T AK++ YP+KG I G SDAD+V+W T++ D H D+ +EG
Sbjct: 372 STMAAKIFNCYPQKGRIAVG-SDADIVIW------NANATRTISKDTHHHAIDFNIFEGM 424
Query: 483 EINNWPRFTIVKGSIVYKEGEIIKENAKGTYV 514
+++ P TI +G V+ G++ G ++
Sbjct: 425 QVHGVPEITISRGRTVWANGQLKTVQGSGQFI 456
>Hs4503377 [F] KOG2584 Dihydroorotase and related enzymes
Length = 572
Score = 192 bits (487), Expect = 1e-48
Identities = 147/513 (28%), Positives = 230/513 (44%), Gaps = 60/513 (11%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHV 65
LLIK G +V + ADI + +G + +G++L + I+A V PGGID H
Sbjct: 17 LLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKTIEAHSRMVIPGGIDVHTRF 76
Query: 66 DEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYETQK 125
P + + AD + T +A+AGGTT +I + T A D + + K
Sbjct: 77 QMPDQGMTS-ADDFFQGTKAALAGGTTMIIDHVVPEPG-TSLLAAFDQWRE----WADSK 130
Query: 126 LYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPG-LQISDYDILT 184
CDY+LH+ + K + ++ ++ +++GV S V+M + Q++D I
Sbjct: 131 SCCDYSLHVDISEWHKG-------IQEEMEALVKDHGVNSFLVYMAFKDRFQLTDCQIYE 183
Query: 185 TMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRAIVLA 244
+ R G VHAENGD++ +++ + +T P H +SRP VE EA NRAI +A
Sbjct: 184 VLSVIRDIGAIAQVHAENGDIIAEEQQRILDLGITGPEGHVLSRPEEVEAEAVNRAITIA 243
Query: 245 KMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQQSTC 304
+ P+ V S + + I A+ KG VY E + + + T H + +
Sbjct: 244 NQTNCPLYITKVMSKSSAEVIAQARKKGTVVYGE-----PITASLGTDGSHYWSKNWAK- 297
Query: 305 SDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPEHCQESVWKA-MNNGTFTIVGSDHCA 363
A + SPP+ P+ + ++ G + GS HC
Sbjct: 298 ----------------------AAAFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCT 335
Query: 364 YNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFVELQC 423
+N K G KDN F IP G G RM +++D V+ GK+ + +FV +
Sbjct: 336 FNTAQKAVG-----KDN----FTLIPEGTNGTEERMSVIWDKAVVTGKM-DENQFVAVTS 385
Query: 424 TNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPYEGFE 483
TN AK++ LYP+KG I G SDADLV+W T++ +Y +EG E
Sbjct: 386 TNAAKVFNLYPRKGRIAVG-SDADLVIW------DPDSVKTISAKTHNSSLEYNIFEGME 438
Query: 484 INNWPRFTIVKGSIVYKEGEIIKENAKGTYVKR 516
P I +G IV ++G + G Y+ R
Sbjct: 439 CRGSPLVVISQGKIVLEDGTLHVTEGSGRYIPR 471
>Hs4503051 [F] KOG2584 Dihydroorotase and related enzymes
Length = 572
Score = 189 bits (479), Expect = 1e-47
Identities = 146/513 (28%), Positives = 237/513 (45%), Gaps = 60/513 (11%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHV 65
LLIK G ++ AD+ + +G + +G++L + I+A G V PGGID + ++
Sbjct: 17 LLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTYL 76
Query: 66 DEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYETQK 125
+P + + AD + T +A+ GGTT +I + + L S + E +T K
Sbjct: 77 QKPSQGM-TAADDFFQGTRAALVGGTTMIIDHVVPEPGSS----LLTSFEKWHEAADT-K 130
Query: 126 LYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL-QISDYDILT 184
CDY+LH+ + S + +L + ++ GV S +V+M Y + Q+SD +
Sbjct: 131 SCCDYSLHVDI-------TSWYDGVREELEVLVQDKGVNSFQVYMAYKDVYQMSDSQLYE 183
Query: 185 TMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRAIVLA 244
+ G +VHAENGD++ +++ E +T P H +SRP +E EA RAI +A
Sbjct: 184 AFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAITIA 243
Query: 245 KMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQQSTC 304
++ P+ V S A D I A+ KG V+ E + + + T H + +
Sbjct: 244 GRINCPVYITKVMSKSAADIIALARKKGPLVFGE-----PIAASLGTDGTHYWSKNWAK- 297
Query: 305 SDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPE-HCQESVWKAMNNGTFTIVGSDHCA 363
A + SPP+ P+ + + + G + GS HC
Sbjct: 298 ----------------------AAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCP 335
Query: 364 YNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFVELQC 423
Y+ K G KDN F IP G+ G+ RM +++D V GK+ + +FV +
Sbjct: 336 YSTAQKAVG-----KDN----FTLIPEGVNGIEERMTVVWDKAVATGKM-DENQFVAVTS 385
Query: 424 TNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPYEGFE 483
TN AK++ LYP+KG I G SDAD+V+W T+T +Y +EG E
Sbjct: 386 TNAAKIFNLYPRKGRIAVG-SDADVVIW------DPDKLKTITAKSHKSAVEYNIFEGME 438
Query: 484 INNWPRFTIVKGSIVYKEGEIIKENAKGTYVKR 516
+ P I +G IV+++G I G ++ R
Sbjct: 439 CHGSPLVVISQGKIVFEDGNINVNKGMGRFIPR 471
>Hs4503379 [F] KOG2584 Dihydroorotase and related enzymes
Length = 570
Score = 187 bits (476), Expect = 3e-47
Identities = 152/511 (29%), Positives = 229/511 (44%), Gaps = 60/511 (11%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHV 65
LLIK G +V + ADI + +G + +G +L + I+A G V PGGID H H
Sbjct: 17 LLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHF 76
Query: 66 DEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYETQK 125
P K + V D + T +A+AGGTT +I D PE+ + K
Sbjct: 77 QMPYKGMTTVDDFFQ-GTKAALAGGTTMII-----DHVVPEPESSLTEAYEKWREWADGK 130
Query: 126 LYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL-QISDYDILT 184
CDYALH+ + H + ++ ++ ++ GV S V+M Y L Q+S+ ++
Sbjct: 131 SCCDYALHVDITHWNDS-------VKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYE 183
Query: 185 TMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRAIVLA 244
+ G VHAENGD++ ++ E +T P H +SRP +E EA RAI +A
Sbjct: 184 IFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIA 243
Query: 245 KMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQQSTC 304
+ P+ V S A D I A+ KG V+ E P A L ID +
Sbjct: 244 SQTNCPLYVTKVMSKSAADLISQARKKGNVVFGE--PITASLG-IDGTHYWS-------- 292
Query: 305 SDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPE-HCQESVWKAMNNGTFTIVGSDHCA 363
K AK A + SPP+ P+ + + + +G + GS HC
Sbjct: 293 ----------KNWAK-------AAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCT 335
Query: 364 YNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFVELQC 423
++ K G KDN F IP G GV RM +++D V GK+ + +FV +
Sbjct: 336 FSTAQKAIG-----KDN----FTAIPEGTNGVEERMSVIWDKAVATGKM-DENQFVAVTS 385
Query: 424 TNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPYEGFE 483
TN AK++ LYP+KG I G SD+DLV+W + +Y +EG E
Sbjct: 386 TNAAKIFNLYPRKGRISVG-SDSDLVIWDPDAVKIVSAKNHQS------AAEYNIFEGME 438
Query: 484 INNWPRFTIVKGSIVYKEGEIIKENAKGTYV 514
+ P I +G I+ ++G + G ++
Sbjct: 439 LRGAPLVVICQGKIMLEDGNLHVTQGAGRFI 469
>Hs11321617 [F] KOG2584 Dihydroorotase and related enzymes
Length = 572
Score = 186 bits (472), Expect = 8e-47
Identities = 147/517 (28%), Positives = 233/517 (44%), Gaps = 68/517 (13%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHV 65
LLI+ G +V + AD+ + +G + +G++L + IDA G V PGG+D H +
Sbjct: 17 LLIRGGRIVNDDQSFYADVHVEDGLIKQIGENLIVPGGIKTIDAHGLMVLPGGVDVHTRL 76
Query: 66 DEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSD----SVKADIELY 121
P+ + P AD + T +A+AGGTT ++ D TG L+ +AD
Sbjct: 77 QMPVLGMTP-ADDFCQGTKAALAGGTTMILDHVFPD---TGVSLLAAYERWRERAD---- 128
Query: 122 ETQKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPG-LQISDY 180
CDY+LH+ + + + +L ++ + GV S VFM Y Q SD
Sbjct: 129 --SAACCDYSLHVDITRWHES-------IKEELEALVKEKGVNSFLVFMAYKDRCQCSDS 179
Query: 181 DILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRA 240
+ R G VHAENGD+V+ ++L E +T P H +S P VE EA RA
Sbjct: 180 QMYEIFSIIRDLGALAQVHAENGDIVEEEQKRLLELGITGPEGHVLSHPEEVEAEAVYRA 239
Query: 241 IVLAKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQ 300
+ +AK + P+ V S A D I A+ +G+ V+ E + + + T H +
Sbjct: 240 VTIAKQANCPLYVTKVMSKGAADAIAQAKRRGVVVFGE-----PITASLGTDGSHYWSKN 294
Query: 301 QSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPE-HCQESVWKAMNNGTFTIVGS 359
+ A + SPP+ P+ + + +++G + GS
Sbjct: 295 WAK-----------------------AAAFVTSPPVNPDPTTADHLTCLLSSGDLQVTGS 331
Query: 360 DHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFV 419
HC + K G KDN F IP G G+ RM ++++ V GK+ + +FV
Sbjct: 332 AHCTFTTAQKAVG-----KDN----FALIPEGTNGIEERMSMVWEKCVASGKM-DENEFV 381
Query: 420 ELQCTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCDYTPY 479
+ TN AK++ YP+KG + G SDADLV+W T++L V +Y +
Sbjct: 382 AVTSTNAAKIFNFYPRKGRVAVG-SDADLVIWNPKATKIISAK---THNLNV---EYNIF 434
Query: 480 EGFEINNWPRFTIVKGSIVYKEGEIIKENAKGTYVKR 516
EG E P I +G + ++G++ G +V R
Sbjct: 435 EGVECRGAPAVVISQGRVALEDGKMFVTPGAGRFVPR 471
>CE28484 [F] KOG2584 Dihydroorotase and related enzymes
Length = 418
Score = 182 bits (462), Expect = 1e-45
Identities = 141/452 (31%), Positives = 213/452 (46%), Gaps = 59/452 (13%)
Query: 6 LLIKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHV 65
L+IKNGTVV ++ AD+ +RNG ++ V ++ EVIDA V PGGID H H+
Sbjct: 5 LVIKNGTVVNEDGMFKADVLVRNGIIVEVSPNITALPDTEVIDATDRLVIPGGIDPHTHM 64
Query: 66 DEPLKLLGPVA-DTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYET- 123
P +G V D + T +AVAGGTT +I F D +S+ A + +
Sbjct: 65 QMPY--MGEVTKDDFLKGTEAAVAGGTTMIIDFCCPDHRN------GESLIAGYNRWRSW 116
Query: 124 --QKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPG-LQISDY 180
K+ CDY L + + + ++ S +GV S K +M Y L + D
Sbjct: 117 ADPKVCCDYGLSVAITMWRPETAEQMAIITSP------EFGVNSFKFYMAYENTLMVRDD 170
Query: 181 DILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRA 240
++ MQ K VH ENG ++K L + +T P H SRP +E EATNRA
Sbjct: 171 ELFRGMQECAKLRALARVHCENGSVIKEKEIDLLAKGVTGPEGHTQSRPEEIEAEATNRA 230
Query: 241 IVLAKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHHELEQQ 300
VLA + P+ VHV + A I + +G V+ E P A L+ +D ++
Sbjct: 231 CVLAAQANCPVYIVHVMTKGAASAISHHRAQGSIVFGE--PIAAGLA-LDGSHYYN---- 283
Query: 301 QSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPI-RPEHCQESVWKAMNNGTFTIVGS 359
+D A+ + SPP+ R E + K + G + G+
Sbjct: 284 ---------------------EDWLHAARYVMSPPLSRDPTTPELLMKLLAAGELHLTGT 322
Query: 360 DHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANMTKFV 419
D+C Y+ K+ GK G F IPNG+ GV RM ++++ GV G + M ++V
Sbjct: 323 DNCTYDCRQKSLGK---------GNFTKIPNGINGVEDRMSVVWEKGVHSGIIDPM-RYV 372
Query: 420 ELQCTNPAKLYGLYPKKGSILPGVSDADLVVW 451
+ + AK++ +YP+KG I G SDAD+V++
Sbjct: 373 SITSSTAAKIFNIYPRKGRIAVG-SDADIVIF 403
>7296724 [F] KOG2584 Dihydroorotase and related enzymes
Length = 311
Score = 121 bits (303), Expect = 3e-27
Identities = 97/293 (33%), Positives = 137/293 (46%), Gaps = 41/293 (13%)
Query: 8 IKNGTVVTASDIYPADIAIRNGKVILVGQDLDTALAEEV--IDAEGAYVTPGGIDAHVHV 65
IKNG +V + AD+ I +G + VG + + V IDA G + PGGID H H+
Sbjct: 24 IKNGEIVNHDKSFKADVYIEDGIIKFVGPSSEITIPGGVRTIDASGLMIIPGGIDPHTHM 83
Query: 66 DEPLKLLGPVA-DTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADIELYETQ 124
P G VA D T +AVAGGTT +I F +K ++ EA D ++ +
Sbjct: 84 QLPFG--GAVAVDDFYHGTKAAVAGGTTMIIDFVLPNKHESMIEAY-DKWRS----WADP 136
Query: 125 KLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGLQISDYDILT 184
K+ CDY LH+ + +K + ++ + + GV S K FM Y GL
Sbjct: 137 KVCCDYGLHVGITW-------WSKSVSEEIGILCKELGVNSFKTFMAYKGLY-------- 181
Query: 185 TMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGEATNRAIVLA 244
VHAENGD++ ++L + + P H +SRP VE EA +RA VLA
Sbjct: 182 ------------QVHAENGDIIAKNTQRLLAEGINGPEGHELSRPEEVEAEAVHRACVLA 229
Query: 245 KMMDTPILFVHVSSPEA-IDTIRSA-QTKGLKVYAETCPQYALLSDIDTKCHH 295
D P+ VHV S A I+ R+ + +G + ET A L T C H
Sbjct: 230 HQADCPLYVVHVMSKSAGIELARARHRYRGRYIMGETLA--AALGTDATCCQH 280
>CE26069 [F] KOG2584 Dihydroorotase and related enzymes
Length = 529
Score = 102 bits (255), Expect = 1e-21
Identities = 108/484 (22%), Positives = 192/484 (39%), Gaps = 90/484 (18%)
Query: 32 ILVGQDLDTALAEEVIDAEGAYVTPGGIDAHVHVDEPLKLLGPVADTMEEATMSAVAGGT 91
I V +L+ EV+DA G P GID + V + D + SA+AGGT
Sbjct: 55 INVAPNLEAPEGAEVLDAAGKLALPAGIDVYTQVTDSS------VDDLSTGCKSAIAGGT 108
Query: 92 TTVITFATQDKTKTGPEALSDSVKADIELYETQKLYCDYALHLILFHIEKPSISGTKLLD 151
T++ G E++ +VK E + C AL S++ T +
Sbjct: 109 GTIVEVVRP----RGAESVVSAVKRVKNQLEKSGISCHVAL----------SVAITDFCE 154
Query: 152 SQLASMYENYGVTSVKVFMTYPGLQISDYDILTTMQATRKNGFTTMVHAENGDMVKWMIE 211
+++ + +N G+ S G+ ++D +L + ++ G V EN +V + +
Sbjct: 155 QEMSELVKNEGINS----FVLDGVSLTDDKLLELFEHVKRLGALIRVVPENKSIVAMLEK 210
Query: 212 QLEEQNMTSPYFHGVSRPTIVEGEATNRAIVLAKMMDTPILFVHVSSPEAIDTIRSAQTK 271
++ + +T P SRP +E + VSS +++ I A+
Sbjct: 211 KMLKLGVTGPEGFPQSRPESLEAD-------------------RVSSADSLAAIEKARAS 251
Query: 272 GLKVYAETCPQYALLSDIDTKCHHELEQQQSTCSDANKSEPRVKLTAKEIDDKFIGAKAI 331
G +AE + S T L Q + A+ ++ ++ A D+ IGA
Sbjct: 252 GALAHAE------IASAAVTADGSALFSQDLRFASAHLTDVPLRRGAP---DRMIGA--- 299
Query: 332 CSPPIRPEHCQESVWKAMNNGTFTIVGSDHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNG 391
++ + S H N + + K +F G
Sbjct: 300 -----------------LSTQPLVVCTSGHRPVNSATRVAAK----------DFAIAQKG 332
Query: 392 MPGVCTRMPLLFDYGVLQGKLANMTKFVELQCTNPAKLYGLYPKKGSILPGVSDADLVVW 451
G RM ++++ V G++ M +FV + TN AK++ +YPKKG I G +DADLV+W
Sbjct: 333 STGAEERMAVVWERAVRSGRIDAM-RFVAVTSTNAAKMFNMYPKKGRIAVG-ADADLVIW 390
Query: 452 XXXXXXXXXXXXTVTNDLLVHGCDYTPYEGFEINNWPRFTIVKGSIVYKEGEIIKENAKG 511
++ + + Y+G +++ TIV G I Y+ GE+ + G
Sbjct: 391 DASGKRVLESSRAQSSQ------ENSMYDGLTVHSVVTATIVGGKIAYQNGEVREAPVAG 444
Query: 512 TYVK 515
+++
Sbjct: 445 GFLR 448
>YIR027c [F] KOG2584 Dihydroorotase and related enzymes
Length = 460
Score = 100 bits (248), Expect = 7e-21
Identities = 123/521 (23%), Positives = 204/521 (38%), Gaps = 87/521 (16%)
Query: 3 TYDLLIKNGTVVTASDIYPAD----IAIRNGKVILVGQDLDTALAEEVIDAEGAYVTPGG 58
T D +I NG A+ +Y + + + G V++ ++ + + + PG
Sbjct: 7 TSDHVIINGANKPATIVYSTESGTILDVLEGSVVMEKTEITKYEIHTLENVSPCTILPGL 66
Query: 59 IDAHVHVDEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVKADI 118
+D+HVH++EP + + E T +A++GG TTV+ P ++ + +
Sbjct: 67 VDSHVHLNEPGRTSW---EGFETGTQAAISGGVTTVVDMPLN---AIPPTTNVENFRIKL 120
Query: 119 ELYETQKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGLQ-- 176
E E Q ++CD L P + L+ + GV K F+ G++
Sbjct: 121 EAAEGQ-MWCDVGFWGGLVPHNLPDL--IPLVKA---------GVRGFKGFLLDSGVEEF 168
Query: 177 --ISDYDILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVS-RPTIVE 233
I I ++ + M HAE + K +Q + + Y +S RP E
Sbjct: 169 PPIGKEYIEEALKVLAEEDTMMMFHAE---LPKAHEDQQQPEQSHREYSSFLSSRPDSFE 225
Query: 234 GEATNRAIVLAKMMD---TPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDID 290
+A N + + + P+ VH++S +AI IR A+ GL V ETC Y ++
Sbjct: 226 IDAINLILECLRARNGPVPPVHIVHLASMKAIPLIRKARASGLPVTTETCFHYLCIA--- 282
Query: 291 TKCHHELEQQQSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPEHCQESVWKAMN 350
A++I D K C PPIR E ++ +W A+
Sbjct: 283 ---------------------------AEQIPDGATYFK--CCPPIRSESNRQGLWDALR 313
Query: 351 NGTFTIVGSDHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQG 410
G V SDH S K+ + G+F G+ V +PL+F G
Sbjct: 314 EGVIGSVVSDH---------SPCTPELKNLQKGDFFDSWGGIASVGLGLPLMFTQG---- 360
Query: 411 KLANMTKFVELQCTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLL 470
++ V C N + GL +KG+I PG DADLVV+ ++N +
Sbjct: 361 --CSLVDIVTWCCKNTSHQVGLSHQKGTIAPGY-DADLVVF------DTASKHKISNSSV 411
Query: 471 VHGCDYTPYEGFEINNWPRFTIVKGSIVYKEGEIIKENAKG 511
T Y G + TI++G +VY + + G
Sbjct: 412 YFKNKLTAYNGMTVKGTVLKTILRGQVVYTNANGVSKTPLG 452
>7293258 [R] KOG0370 Multifunctional pyrimidine synthesis protein CAD
(includes carbamoyl-phophate synthetase aspartate
transcarbamylase and glutamine amidotransferase)
Length = 2189
Score = 72.8 bits (177), Expect = 1e-12
Identities = 103/473 (21%), Positives = 177/473 (36%), Gaps = 124/473 (26%)
Query: 56 PGGIDAHVHVDEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVK 115
PG ID HVH+ EP + T +A+AGG T V T P +
Sbjct: 1445 PGFIDVHVHLREPG---ATHKEDFASGTAAALAGGVTLVCAMPN-----TNPSIVDRETF 1496
Query: 116 ADIELYETQKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL 175
+ CDYAL++ + +N+ + ++ GL
Sbjct: 1497 TQFQELAKAGARCDYALYV--------------------GASDDNWAQVN-ELASHACGL 1535
Query: 176 QISDYDILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIV--- 232
++ D T++ + DM W +++++ H R IV
Sbjct: 1536 KMYLNDTFGTLKLS--------------DMTSW------QRHLS----HWPKRSPIVCHA 1571
Query: 233 EGEATNRAIVLAKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLS--DID 290
E ++T I+LA ++D + HV+ E I IRSA+ KG+KV E CP + LS D++
Sbjct: 1572 ERQSTAAVIMLAHLLDRSVHICHVARKEEIQLIRSAKEKGVKVTCEVCPHHLFLSTKDVE 1631
Query: 291 TKCHHELEQQQSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPEHCQESVWKAMN 350
H E + CS PE QE++W+ N
Sbjct: 1632 RLGHGMSEVRPLLCS--------------------------------PED-QEALWE--N 1656
Query: 351 NGTFTIVGSDHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQG 410
+ +DH + +K S + P G PGV T +PLL V +G
Sbjct: 1657 IDYIDVFATDHAPHTLAEKRSER--------------PPPGFPGVETILPLLLQ-AVHEG 1701
Query: 411 KLANMTKFVELQCTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLL 470
+L M NP ++ L + + + D + W T+T + +
Sbjct: 1702 RL-TMEDIKRKFHRNPKIIFNLPDQAQTYVEVDLDEE---W------------TITGNEM 1745
Query: 471 VHGCDYTPYEGFEINNWPRFTIVKGSIVYKEGEIIKENAKGTYVKRGKSQLCT 523
+TP+EG ++ +++G + + +G+++ + G V+ +S L +
Sbjct: 1746 KSKSGWTPFEGTKVKGRVHRVVLRGEVAFVDGQVLVQPGFGQNVRPKQSPLAS 1798
>Hs18105007 [R] KOG0370 Multifunctional pyrimidine synthesis protein CAD
(includes carbamoyl-phophate synthetase aspartate
transcarbamylase and glutamine amidotransferase)
Length = 2225
Score = 60.8 bits (146), Expect = 5e-09
Identities = 94/461 (20%), Positives = 170/461 (36%), Gaps = 114/461 (24%)
Query: 56 PGGIDAHVHVDEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVK 115
PG ID HVH+ EP G + T +A+AGG T V T P +
Sbjct: 1465 PGLIDVHVHLREPG---GTHKEDFASGTAAALAGGITMVCAMPN-----TRPPIIDAPAL 1516
Query: 116 ADIELYETQKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL 175
A + CD+AL L + EN G V + GL
Sbjct: 1517 ALAQKLAEAGARCDFALFL--------------------GASSENAGTLGT-VAGSAAGL 1555
Query: 176 QISDYDILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGE 235
++ + + ++ +V+WM E E P + T+
Sbjct: 1556 KLYLNETFSELRLD--------------SVVQWM-EHFETWPSHLPIVAHAEQQTVAA-- 1598
Query: 236 ATNRAIVLAKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKCHH 295
+++A++ + HV+ E I I++A+ +GL V E P + LS H
Sbjct: 1599 ----VLMVAQLTQRSVHICHVARKEEILLIKAAKARGLPVTCEVAPHHLFLS------HD 1648
Query: 296 ELEQQQSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPEHCQESVWKAMNNGTFT 355
+LE+ K E R +L +++ E++W+ N
Sbjct: 1649 DLER-----LGPGKGEVRPELGSRQ--------------------DVEALWE--NMAVID 1681
Query: 356 IVGSDHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLANM 415
SDH + +K + P G PG+ T +PLL V +G+L ++
Sbjct: 1682 CFASDHAPHTLEEKCGSR--------------PPPGFPGLETMLPLLLT-AVSEGRL-SL 1725
Query: 416 TKFVELQCTNPAKLYGLYPKKGSILPGVSDADLVVWXXXXXXXXXXXXTVTNDLLVHGCD 475
++ NP +++ L P++ + + + DL T+ + +
Sbjct: 1726 DDLLQRLHHNPRRIFHLPPQEDTYV----EVDL-----------EHEWTIPSHMPFSKAH 1770
Query: 476 YTPYEGFEINNWPRFTIVKGSIVYKEGEIIKENAKGTYVKR 516
+TP+EG ++ R +++G + Y +G+++ G V++
Sbjct: 1771 WTPFEGQKVKGTVRRVVLRGEVAYIDGQVLVPPGYGQDVRK 1811
>CE03105 [R] KOG0370 Multifunctional pyrimidine synthesis protein CAD
(includes carbamoyl-phophate synthetase aspartate
transcarbamylase and glutamine amidotransferase)
Length = 2198
Score = 57.4 bits (137), Expect = 5e-08
Identities = 80/382 (20%), Positives = 140/382 (35%), Gaps = 104/382 (27%)
Query: 56 PGGIDAHVHVDEPLKLLGPVADTMEEATMSAVAGGTTTVITFATQDKTKTGPEALSDSVK 115
PG +D HVHV EP + + +A+AGG TT++ T P +
Sbjct: 1477 PGMVDIHVHVREPG---ATHKEDWATCSKAALAGGVTTILAMPN-----TSPVLVDTDSF 1528
Query: 116 ADIELYETQKLYCDYALHLILFHIEKPSISGTKLLDSQLASMYENYGVTSVKVFMTYPGL 175
E + K DYAL++ G +S+ A+ + + GL
Sbjct: 1529 YQTEQLASAKSVVDYALYI-----------GATPNNSKFAAEFADKAA----------GL 1567
Query: 176 QISDYDILTTMQATRKNGFTTMVHAENGDMVKWMIEQLEEQNMTSPYFHGVSRPTIVEGE 235
++ + +T++ + + + A +RP + E
Sbjct: 1568 KMYLNETFSTLKMDNISDWAKHLSA-----------------------FPANRPIVCHAE 1604
Query: 236 ATNRAIVL--AKMMDTPILFVHVSSPEAIDTIRSAQTKGLKVYAETCPQYALLSDIDTKC 293
A +L A+M + + HV++ + I+ ++ A+ +G V E CP
Sbjct: 1605 KQTLAAILCMAQMANRAVHIAHVATADEINLVKEAKQRGWNVTCEVCP------------ 1652
Query: 294 HHELEQQQSTCSDANKSEPRVKLTAKEIDDKFIGAKAICSPPIRPEHCQESVWKAMNNGT 353
HH ++ + PR+ ++PE ++++W M
Sbjct: 1653 HHLFLIEEDLPDGIREVRPRL---------------------VKPED-RQALWDNMEY-- 1688
Query: 354 FTIVGSDHCAYNYYDKTSGKLDAFKDNKNGEFKYIPNGMPGVCTRMPLLFDYGVLQGKLA 413
+DH + + +KT KD K IP G PGV +PLL V GKL
Sbjct: 1689 IDCFATDHAPHTWAEKTG------KDGK------IPPGFPGVEYMLPLLLT-AVHDGKL- 1734
Query: 414 NMTKFVELQCTNPAKLYGLYPK 435
M + + TNP +++ L P+
Sbjct: 1735 TMKELTDRMSTNPRRIFNLPPQ 1756
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,094,701
Number of Sequences: 60738
Number of extensions: 1420924
Number of successful extensions: 3262
Number of sequences better than 1.0e-05: 16
Number of HSP's better than 0.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 3175
Number of HSP's gapped (non-prelim): 34
length of query: 543
length of database: 30,389,216
effective HSP length: 111
effective length of query: 432
effective length of database: 23,647,298
effective search space: 10215632736
effective search space used: 10215632736
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)