ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV0197 good T KOG0169 Signal transduction mechanisms Phosphoinositide-specific phospholipase C
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV0197 63120 60193 -976
(976 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPL268w [T] KOG0169 Phosphoinositide-specific phospholipase C 591 e-168
SPAC22F8.11 [T] KOG0169 Phosphoinositide-specific phospholipase C 351 4e-96
Hs19115964 [T] KOG0169 Phosphoinositide-specific phospholipase C 223 1e-57
Hs14249340 [T] KOG0169 Phosphoinositide-specific phospholipase C 209 1e-53
Hs5453910 [T] KOG0169 Phosphoinositide-specific phospholipase C 180 8e-45
Hs14916457 [T] KOG0169 Phosphoinositide-specific phospholipase C 160 9e-39
Hs12083581 [I] KOG1265 Phospholipase C 155 4e-37
CE07421 [T] KOG0169 Phosphoinositide-specific phospholipase C 153 1e-36
CE12090 [T] KOG0169 Phosphoinositide-specific phospholipase C 138 4e-32
Hs4505871 [I] KOG1264 Phospholipase C 138 5e-32
Hs4505869 [I] KOG1264 Phospholipase C 138 5e-32
Hs18598741 [I] KOG1264 Phospholipase C 138 5e-32
Hs14731274 [T] KOG0169 Phosphoinositide-specific phospholipase C 134 5e-31
7296215 [I] KOG1265 Phospholipase C 134 9e-31
CE02307 [I] KOG1264 Phospholipase C 133 2e-30
Hs20475709 [T] KOG0169 Phosphoinositide-specific phospholipase C 132 2e-30
CE20375 [I] KOG1265 Phospholipase C 129 2e-29
7293213 [I] KOG1264 Phospholipase C 128 4e-29
Hs4505867 [I] KOG1265 Phospholipase C 127 1e-28
Hs11386139 [I] KOG1265 Phospholipase C 124 5e-28
Hs5453912 [T] KOG0169 Phosphoinositide-specific phospholipase C 122 4e-27
CE27569 [I] KOG1265 Phospholipase C 117 9e-26
CE23507 [I] KOG1265 Phospholipase C 117 9e-26
At5g58690 [T] KOG0169 Phosphoinositide-specific phospholipase C 115 3e-25
Hs4758938 [I] KOG1265 Phospholipase C 112 2e-24
At4g38530 [T] KOG0169 Phosphoinositide-specific phospholipase C 103 1e-21
At3g08510 [T] KOG0169 Phosphoinositide-specific phospholipase C 100 1e-20
At3g55940 [T] KOG0169 Phosphoinositide-specific phospholipase C 94 1e-18
At5g58670 [T] KOG0169 Phosphoinositide-specific phospholipase C 89 3e-17
At5g58700 [T] KOG0169 Phosphoinositide-specific phospholipase C 86 4e-16
At3g47290 [T] KOG0169 Phosphoinositide-specific phospholipase C 75 5e-13
At3g47220 [T] KOG0169 Phosphoinositide-specific phospholipase C 71 7e-12
>YPL268w [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 869
Score = 591 bits (1523), Expect = e-168
Identities = 341/837 (40%), Positives = 476/837 (56%), Gaps = 96/837 (11%)
Query: 140 LLKVTRRKRVRYTFHIDQNT--ISWNNGKKLIYVDTIKDIRSGDMATNYMDMYNVPCPSR 197
++++TRR+R Y F + N I W +G K + +D++KDIR GD A+ Y + +
Sbjct: 115 MIRMTRRRRKFYEFKLINNNGQIIWKDGSKYLELDSVKDIRIGDTASTYQEEVDPKRLRS 174
Query: 198 D--LWCTIIYSVNKNRLKALHVIAEDAAVFKSFYETTVNLVNSRRKLMEDIAVPNNEQFA 255
D LW IIY V+ N+LKALHV+A + F +F LV RR+LME I +P+N QFA
Sbjct: 175 DSKLWIAIIYKVS-NKLKALHVVALNELDFNTFLSCICGLVKLRRELMESILLPDNSQFA 233
Query: 256 NIHWQTSVSTKKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKADTNNNSLLNFPE 315
IHWQ +VS K+ED+ KDTLSFADVK+LC+++HIY S L F AD N+N LLN+ E
Sbjct: 234 RIHWQITVSEKEEDEKKDTLSFADVKKLCDKFHIYVSTGQLLEFFQLADINHNGLLNYFE 293
Query: 316 FQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEVISQTNAYKIFKKYCT 375
F+ F+K LK R E+ +IW++ + F++F+QF+ Q E + + A+ F KY
Sbjct: 294 FEKFIKILKNRKEVNMIWSKFTKPPHSHLSFENFFQFLITEQHEQVDRQTAWSYFIKYRE 353
Query: 376 ADEL-LDVEGLLKFLTKQPFL-QLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAY 433
+L + +G KFL +QP+L ++ EE YS+PLN YFI+SSHNTYL+GKQ+ + SVE Y
Sbjct: 354 PTQLTMGQDGFTKFLKEQPYLVEVKEELYSKPLNHYFIASSHNTYLLGKQIAETPSVEGY 413
Query: 434 TRALQQGCRCIEIDIWQGDHGPVVCHGLFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEI 493
+ LQQGCRC+EIDIW G++GPVVCHG T +IPL+ V++ I+KYAFITSPYPLI+SLEI
Sbjct: 414 IQVLQQGCRCVEIDIWDGENGPVVCHGFLTSAIPLKTVIRVIKKYAFITSPYPLIISLEI 473
Query: 494 HCKKDYQLMITKIMKEILGDLIFVIPPNTSLL-SPEQLKNRIILKSKKTHAVXXXXXXXX 552
+C KD Q + + IM+E+L + ++ + T L SP +LK++I+LKSKKT
Sbjct: 474 NCNKDNQKLASLIMREVLAEQLYFVGTRTDKLPSPRELKHKILLKSKKT---SEATRGLS 530
Query: 553 XXXXXXXXXXXXXXXXNDMRLIKKRGLQKXXXXXXXXXXXXXXXXXKRNNKSLLLSTKIM 612
N+ L K + K + L
Sbjct: 531 VNEPFPSSFSSSYESANEQELRMK--------DDSTNSSSATNSSSMQRIKRIGLKKHAD 582
Query: 613 ISDKVHEISGIHGVRFRNFSLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLM 672
I + V ISGIHG++FRNFSLPESKT HCFSL+E+K + KD+ KL+++KHNRR+LM
Sbjct: 583 IINDVSNISGIHGIKFRNFSLPESKTIAHCFSLNERKVEYMIKDKHLKLSLDKHNRRYLM 642
Query: 673 RIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDR--NSIWHSG 730
R+YPH+LRYKSSNFNPI FWK GVQMVATNWQT D+GQQLN AMFQ+ LD + + SG
Sbjct: 643 RVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQI-LDHQPDGSFKSG 701
Query: 731 YVLKPAHLRKEIHKMKDIPVIMERLKREKIHIHLDVISGQMLSLQNCKILAPFVEIELIT 790
YVLKP L +PV+ + I+ H + S + V+I +++
Sbjct: 702 YVLKPKKL---------LPVVTKAKMIPLIYEHFENGSDPVT-----------VKIRILS 741
Query: 791 DNTMESLHLTNCLQPMGYTSNNSTHATGITSMSNASNGTFANITSTSTKRVDSNGSSGKT 850
+ L+ T+ S N+T+ S +V+ + T
Sbjct: 742 TQLLPRLNDTS-------PSRNNTN---------------------SFVKVEFHTDDEPT 773
Query: 851 EPLCESNGTTVISGLSAEDGIXXXXXXXXXXXXXXXXXXQLFSTKCFRDNGFSPVWNASF 910
P+ GT + SA + STK + NGF+P+W+A
Sbjct: 774 MPISIDKGTRI----SATEA----------------------STKSSQGNGFNPIWDAEV 807
Query: 911 ECXXXXXXXXXXXXXXXXSTQTIATTCVRLNYLKQGYRHLPLYNIKGEKFIFSTLFI 967
IA+ C++LNYL+ GYRH+PL+N++GE++IF TLFI
Sbjct: 808 SITLKDTDLTFIKFMVISEETQIASVCLKLNYLRMGYRHIPLFNMEGEQYIFCTLFI 864
>SPAC22F8.11 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 899
Score = 351 bits (900), Expect = 4e-96
Identities = 261/773 (33%), Positives = 372/773 (47%), Gaps = 78/773 (10%)
Query: 46 SLEDGSNSDMSSKSTAPSSGSEESFVYDHIYKGIKGFLSRRXXXXXXXXXXXXXXXXXTS 105
+L SNS S ST +S SE F G +LS + TS
Sbjct: 76 TLRKRSNSLSSFLSTKSTSASENKF------HGGLNWLSLKLNLLLRLQGRMNSARTNTS 129
Query: 106 QLGGPLTYALSSNLR-LESTDSGFGSFSADPLDLP--------LLKVTRRKRVRYTFHID 156
P + + NL L S + F S +P LL++T++K + +D
Sbjct: 130 M--NPYSCDSNENLSTLSSVNQNFNSRQLLATIVPESIQNGCSLLRITKKKVRQRKVSLD 187
Query: 157 QNT----ISWNNGK--KLIYVDTIKDIRSGDMATNYMDMYNVPCPSRDLWCTIIYSVNKN 210
+ + N GK K + VD IK+IR G A NY + Y + + W TIIY + N
Sbjct: 188 PISGYLMLDKNTGKAYKKLCVDDIKEIRQGRDARNYREQYKISSENEKRWFTIIYCAD-N 246
Query: 211 RLKALHVIAEDAAVFKSFYETTVNLVNSRRK---LMEDIAVPNNEQFANIHWQTSVSTKK 267
+LKA+H+I+ + L R + ++ E+ + + K
Sbjct: 247 KLKAMHMISPTLDAHNQWIMALEGLKTYRLNEFIIGLNLVCHQGEKMIDYSENLNPWEKL 306
Query: 268 EDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKADTNNNSLLNFPEFQDFVKYLKARP 327
E + L DV R+C H+ S +L F KAD +++ L+F EFQ FV LK R
Sbjct: 307 EKEQSAQLDLGDVHRMCQMLHLNASMEFLEETFQKADADHSGKLSFEEFQHFVSLLKTRS 366
Query: 328 EIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEVISQTNAYKIFKKYCTADE----LLDVE 383
EI I+ + + K+ + F F+ Q + + ++ +C+ D+ L++
Sbjct: 367 EIVDIFKEYTSGSDKM-SLEQFRHFLSTSQKARLDSDSIRTLYVSFCSNDDSKMGLIEFT 425
Query: 384 GLLKFLTKQPFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRC 443
L P + + + D SRPLNEY ISSSHNTYL+GKQ E S+E Y R+LQ+GC+C
Sbjct: 426 SFLLSPHNSPVVPVIQ-DMSRPLNEYLISSSHNTYLLGKQFGGESSIEGYIRSLQRGCKC 484
Query: 444 IEIDIWQGDHGPVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLM 502
IEID W G +GPVVCHG FT I DV+ IRKYAF+ SPYPL +SLEIHC D Q
Sbjct: 485 IEIDCWDGPNGPVVCHGHTFTSMIKFNDVIDAIRKYAFVVSPYPLFISLEIHCCPDQQRQ 544
Query: 503 ITKIMKEILGDLIFVIP--PNTSLL-SPEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXX 559
+ MK+ GD + + P N S+L SPE L N+I+LK K + A
Sbjct: 545 MVSYMKQAFGDTLVMKPVTANESVLPSPEDLLNKILLKVKCS-ATPLHQFSTDILKVGIT 603
Query: 560 XXXXXXXXXNDMRLIKKRGLQKXXXXXXXXXXXXXXXXXKRNNKSLLLSTKIMISDKVHE 619
+++ + GL+K KR K++++ ++
Sbjct: 604 DSSTDTTESSELENSELTGLRKG----------------KRRMKNIIVQELQQLAPYARS 647
Query: 620 ISGIHGVRFRNFSLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHML 679
+ +FRNFSLPESKT +H FS SE+ K +L+ KHN R+L R+YP L
Sbjct: 648 L------KFRNFSLPESKTYSHIFSFSERTIKKHGKAMVPRLS--KHNLRYLCRVYPGPL 699
Query: 680 RYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLR 739
R S+NFNP +W+ GVQMVA NWQTYD G Q+N A+F +GY+LKP
Sbjct: 700 RVGSTNFNPQVYWRLGVQMVALNWQTYDTGLQINDALFIADPP------TGYLLKP---- 749
Query: 740 KEIHKMKDIPVIMERLKREKIHIHLDVISGQML----SLQNCKILAPFVEIEL 788
++ V E L R KI + +DVISGQ L L N + L+P+VEI++
Sbjct: 750 -PCQRIIGTTVGEEGLPR-KIKLTIDVISGQQLRRARELSNSETLSPYVEIQV 800
>Hs19115964 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 789
Score = 223 bits (567), Expect = 1e-57
Identities = 187/643 (29%), Positives = 277/643 (42%), Gaps = 80/643 (12%)
Query: 168 LIYVDTIKDIRSGDMATNYMDMYNVPCPSRDLWCTIIYSVNKNRLKALHVIAEDAAVFKS 227
+ +V I+ +R G + P+R L TI + K R K L + A A
Sbjct: 108 IFFVQHIEAVREGHQSEGLRRFGGAFAPARCL--TIAF---KGRRKNLDLAAPTA----- 157
Query: 228 FYETTVNLVNSRRKLMEDIAVPNNEQFANIHWQTSVSTKKEDQDKDTLSFADVKRLCNRY 287
E V KL + + + + HW S + + +SF ++K L
Sbjct: 158 --EEAQRWVRGLTKLRARLDAMSQRERLD-HWIHSYLHRADSNQDSKMSFKEIKSLLRMV 214
Query: 288 HIYCSDNYLYALFIKADTNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQ 347
++ +D Y Y LF + D +NN L E ++F++ L RPE+E I++Q +D +V+
Sbjct: 215 NVDMNDMYAYLLFKECDHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGED-RVLSAP 273
Query: 348 SFYQFICDVQGEVISQTNAYKIFKKY-----CTADELLDVEGLLKFLTKQPFLQLFE--- 399
+F+ D E + A ++ + Y EL+ ++G + +L L
Sbjct: 274 ELLEFLEDQGEEGATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHT 333
Query: 400 ---EDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQGDHG-P 455
+D ++PL YFISSSHNTYL Q+ S EAY RA QGCRC+E+D W+G G P
Sbjct: 334 CVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEP 393
Query: 456 VVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDL 514
V+ HG T I DVV+ +R +AF SPYP+I+SLE HC + Q + + + ILGD+
Sbjct: 394 VIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDM 453
Query: 515 IFV----IPPNTSLLSPEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXXXXXXXXXXND 570
+ P L SPEQLK R+++K KK A D
Sbjct: 454 LVTQALDSPNPEELPSPEQLKGRVLVKGKKLPA----------------------ARSED 491
Query: 571 MRLIKKRGLQKXXXXXXXXXXXXXXXXXKRNNKSLLLSTKIMISDKVHEISGIHGVRFRN 630
R + R ++ S LS + H R R
Sbjct: 492 GRALSDREEEEEDDEEEEEEVEAAAQRRLAKQISPELSALAVY---------CHATRLRT 542
Query: 631 F-SLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPI 689
P + SLSE+K L ++ +HN R L R+YP LR S+N++P
Sbjct: 543 LHPAPNAPQPCQVSSLSERKAKKLIREAGNSFV--RHNARQLTRVYPLGLRMNSANYSPQ 600
Query: 690 RFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKEIHKMKDIP 749
W G Q+VA N+QT LN F V+ GYVLKPA LR+ D
Sbjct: 601 EMWNSGCQLVALNFQTPGYEMDLNAGRFLVN------GQCGYVLKPACLRQ-----PDST 649
Query: 750 VIMERLKREKIHIHLDVISGQMLSLQNCK----ILAPFVEIEL 788
E + + + V++ Q L N + I+ P V IE+
Sbjct: 650 FDPEYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEI 692
>Hs14249340 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 762
Score = 209 bits (533), Expect = 1e-53
Identities = 183/642 (28%), Positives = 284/642 (43%), Gaps = 87/642 (13%)
Query: 202 TIIYSVNKNRLKALHVIAEDAAVFKSFYETTVNLVNSRRKLMEDIAVPNNEQFANIHWQT 261
TI++ ++ L + E+A ++ + V+LV S + Q W +
Sbjct: 92 TIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSM-----------DHQERLDQWLS 140
Query: 262 SVSTKKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKADTNNNSLLNFPEFQDFVK 321
+ + +SF +V+RL + ++ Y ++LF ADT+ + L EF F K
Sbjct: 141 DWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYK 200
Query: 322 YLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEVISQTN-AYKIFKKYCTADE-- 378
L R E++ ++ + D + + F F+ + Q E + A ++ +Y +D
Sbjct: 201 ALTKRAEVQELFESF-SADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGK 259
Query: 379 ---LLDVEGLLKFLTKQ------PFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVS 429
+L ++G L +L + P +D ++PLN YFI SSHNTYL+G Q+ + S
Sbjct: 260 LRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSS 319
Query: 430 VEAYTRALQQGCRCIEIDIWQGDHG-PVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPL 487
VE Y RAL++GCRC+E+D+W G G PVV HG T I +DVV T+ +YAF TS YP+
Sbjct: 320 VEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPV 379
Query: 488 IVSLEIHCKKDYQLMITKIMKEILGDLIF------VIPPNTSLLSPEQLKNRIILKS-KK 540
I+SLE HC + Q + + + EILG+ + V+P T L SPE+L+ +I++K K
Sbjct: 380 ILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLP--TQLPSPEELRRKILVKGKKL 437
Query: 541 THAVXXXXXXXXXXXXXXXXXXXXXXXXNDMRLIKKRGLQKXXXXXXXXXXXXXXXXXKR 600
T +++ LQ K+
Sbjct: 438 TLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDK--------------KK 483
Query: 601 NNKSLLLSTKIMISDKVHEISGIHGVRFRNFSLPESKTTTHCF---SLSEKKFINLDKDE 657
+K +L + + + V FR+F+ SK H + S SE K L K+
Sbjct: 484 KSKPILCPALSSL------VIYLKSVSFRSFT--HSKEHYHFYEISSFSETKAKRLIKEA 535
Query: 658 TQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMF 717
+ +HN L R+YP LR SSN+NP W G QMVA N QT L + F
Sbjct: 536 GNEFV--QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHF 593
Query: 718 QVSLDRNSIWHSGYVLKPAHLR---KEIHKMKDIPVIMERLKREKIHIHLDVISGQML-- 772
+ + GYVLKP LR H K I + + + VISGQ L
Sbjct: 594 RQN------GGCGYVLKPDFLRDIQSSFHPEKPISPFKAQT------LLIQVISGQQLPK 641
Query: 773 --SLQNCKILAPFVEIELITDNTMESLHLTNCLQPMGYTSNN 812
+ I+ P V++++ + L Q Y NN
Sbjct: 642 VDKTKEGSIVDPLVKVQIF------GVRLDTARQETNYVENN 677
>Hs5453910 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 756
Score = 180 bits (457), Expect = 8e-45
Identities = 189/687 (27%), Positives = 288/687 (41%), Gaps = 92/687 (13%)
Query: 140 LLKVT----RRKRVRYTFHIDQNTISWNNGKK--------LIYVDTIKDIRSGDMATNYM 187
LLKV RR+R Y D TI W +K L ++ I+++R G T +
Sbjct: 28 LLKVKSSSWRRERF-YKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRMGHR-TEGL 84
Query: 188 DMYNVPCPSRDLWCTIIYSVNKNRLKALHVIAEDAAVFKSFYETTVN---LVNSRRKLME 244
+ + P D +I++ +N L + DA + ++ ++ R+KL
Sbjct: 85 EKFARDVPE-DRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQ- 142
Query: 245 DIAVPNNEQFANIHWQTSVSTKKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKAD 304
HW S K + + +SF +++ +I D+Y +F + D
Sbjct: 143 -------------HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECD 189
Query: 305 TNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMKNK-DTKVVD-FQSFYQFICDVQGEVIS 362
+ L E + F K L R EI+ + + +T VD +F Q + E
Sbjct: 190 HSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGPGETLSVDQLVTFLQH--QQREEAAG 247
Query: 363 QTNAYKIFKKY-----CTADELLDVEGLLKFLTKQPFLQL------FEEDYSRPLNEYFI 411
A + ++Y A + +G L +L +D +PL+ Y +
Sbjct: 248 PALALSLIERYEPSETTKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLV 307
Query: 412 SSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG-DHGPVVCHG-LFTQSIPLE 469
SSSHNTYL+ Q+ S EAY RAL +GCRC+E+D W G + P++ HG FT I
Sbjct: 308 SSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFC 367
Query: 470 DVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIFVIP---PNTSLLS 526
DV++ IR YAF SPYP+I+SLE HC + Q ++ + + ILG ++ P SL S
Sbjct: 368 DVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPS 427
Query: 527 PEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXXXXXXXXXXNDMRLIKKRGLQKXXXXX 586
PEQLK +I+LK KK + ++ ++ R
Sbjct: 428 PEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE--AVRSR--------- 476
Query: 587 XXXXXXXXXXXXKRNNKSLLLSTKIMISDKVHEISGIHGVRFRNFSLP--ESKTTTHCFS 644
K L L+ + +SD V +H F FS P + S
Sbjct: 477 ---------VQHKPKEDKLRLAQE--LSDMVIYCKSVH---FGGFSSPGTPGQAFYEMAS 522
Query: 645 LSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQ 704
SE + + L ++ +HN HL RIYP R SSN++P+ W G Q+VA N+Q
Sbjct: 523 FSENRALRLLQESGNGFV--RHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQ 580
Query: 705 TYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKEIHKMKDIPVIMERLKREKIHIHL 764
T + FQ D + GYVLKPA LR + K +++
Sbjct: 581 TPGPEMDVYQDRFQ---DNGA---CGYVLKPAFLRDPNGTFNPRALAQGPWWARK-RLNI 633
Query: 765 DVISGQMLSLQN---CKILAPFVEIEL 788
VISGQ L N I+ P V +E+
Sbjct: 634 RVISGQQLPKVNKNKNSIVDPKVTVEI 660
>Hs14916457 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 504
Score = 160 bits (405), Expect = 9e-39
Identities = 125/404 (30%), Positives = 190/404 (46%), Gaps = 66/404 (16%)
Query: 361 ISQTNAYKIFKKYCTADEL-----LDVEGLLKFLTKQPFLQLFEE------DYSRPLNEY 409
+S+ A++I +KY +E+ + +EG +++ + L E D + PLN+Y
Sbjct: 1 MSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDY 60
Query: 410 FISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG-DHGPVVCHG-LFTQSIP 467
FISSSHNTYL+ Q++ + Y AL +GCRC+EID W G + PVV HG T +
Sbjct: 61 FISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLL 120
Query: 468 LEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIM-----KEILGDLIFVIPPNT 522
+ V++ I KYAF+TS YP+++SLE HC Q ++ + + +L D++ P
Sbjct: 121 FKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFP--D 178
Query: 523 SLLSPEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXXXXXXXXXXNDMRLIKKRGLQKX 582
+L SPE LK ++++K+KK + ++ + KRG +
Sbjct: 179 TLPSPEALKFKVLVKNKKIGTL---------------------KETHERKGSDKRGDNQD 217
Query: 583 XXXXXXXXXXXXXXXXKRNNK---SLLLSTKIMISDKVHEISGIHGVRFRNFSLPESKTT 639
K+ K +L LS ++ + S H ++ F+ S
Sbjct: 218 KETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGE 277
Query: 640 THCFSLSEKKFINLDKDETQKLAINK---HNRRHLMRIYPHMLRYKSSNFNPIRFWKEGV 696
T LS KL +++ H R+ + RIYP R SSNFNP FW G
Sbjct: 278 TQARKLS-------------KLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGC 324
Query: 697 QMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRK 740
QMVA N+QT L L + F LD SGY+LKP LR+
Sbjct: 325 QMVALNFQTPGLPMDLQNGKF---LDNGG---SGYILKPHFLRE 362
>Hs12083581 [I] KOG1265 Phospholipase C
Length = 1216
Score = 155 bits (391), Expect = 4e-37
Identities = 133/508 (26%), Positives = 224/508 (43%), Gaps = 53/508 (10%)
Query: 316 FQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEV---------ISQTNA 366
++ F+ L RPEI+ I+++ K + FI Q + + Q
Sbjct: 212 YRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQV 271
Query: 367 YKIFKKYCTADEL-----LDVEGLLKFLTKQ------PFLQLFEEDYSRPLNEYFISSSH 415
+ +KY + L + V+G +++L+ + P ED S+PL+ YFI+SSH
Sbjct: 272 QVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSH 331
Query: 416 NTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG---DHGPVVCHGL-FTQSIPLEDV 471
NTYL Q+ SVE Y + L GCRC+E+D W+G + PV+ HG T I ++V
Sbjct: 332 NTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEV 391
Query: 472 VKTIRKYAFITSPYPLIVSLEIHC-KKDYQLMITKIMKEILGDLIFVIP-------PNTS 523
++ I + AF TSP+P+++S E H Q + + + I GD + + P
Sbjct: 392 IEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVP 451
Query: 524 LLSPEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXXXXXXXXXXNDMRLIKKRGLQKXX 583
L SP L +I++K+KK + + +
Sbjct: 452 LPSPMDLMYKILVKNKK-----KSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGE 506
Query: 584 XXXXXXXXXXXXXXXKRNNKSLLLSTKIMISDKVHE-ISGIHGVRFRNFSLPESKTTTHC 642
K + ++ M ++++ ++ I V+F +F + SK
Sbjct: 507 ADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEI--SKKRNKS 564
Query: 643 FSLSE-KKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVAT 701
F +S + L++ + ++N+ L RIYP R SSN+ P FW G QMVA
Sbjct: 565 FEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVAL 624
Query: 702 NWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRK-EIHKMKDIPVIMERLKREKI 760
N+QT DL Q+N M++ + SGY LKP +R+ + H I++ + +
Sbjct: 625 NFQTMDLAMQINMGMYEYN------GKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTL 678
Query: 761 HIHLDVISGQMLSLQNCKILAPFVEIEL 788
+ +ISGQ LS K + +VE+++
Sbjct: 679 SV--KIISGQFLS---DKKVGTYVEVDM 701
>CE07421 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 751
Score = 153 bits (387), Expect = 1e-36
Identities = 114/401 (28%), Positives = 198/401 (48%), Gaps = 32/401 (7%)
Query: 164 NGKKLIYVDTIKDIRSGDMATNYM---DMYNVPCPSRDLWCTIIYSVNKNRLKALHVIAE 220
N K + + + ++RSG N Y + + C +SV + K LH +
Sbjct: 69 NALKSVALSELLEVRSGYQTDNLQRASKKYEFQELAPESRC---FSVIFSHAKFLHKSVD 125
Query: 221 DAAVFKSFYETTVNLVNSRRKLMEDIAVPNNEQFANIHWQTSVSTKKEDQDKDTLSFADV 280
+A K + V+++ + +A F W + + LSF +V
Sbjct: 126 FSADSKETRDKWVSVLTH----LISVAKHQRVVFNETAWLIDKFQQADTNKNGLLSFDEV 181
Query: 281 KRLCNRYHIYCSDNYLYALFIKADTNNN--SLLNFPEFQDFVKYLKARPEIEIIWNQMKN 338
L R ++ S+ Y A+F +++ N+ + LN EF +F + L RP++ + Q +
Sbjct: 182 WNLLKRMNLQISERYAKAIFRESEFENSRDNKLNEKEFLNFFERLTDRPDLRFVMTQASS 241
Query: 339 KDTKVVDFQSFYQFICDVQG-EVISQTNAYKIFKKYCTA------DELLDVEGLLKFLTK 391
+ + + +F+ + QG E + A +I + ++L+ + G+ + +
Sbjct: 242 DNVETLTVADLQRFLTEEQGFENVDLKKAEQILTTFEQTVQDKQKEKLMGLMGMRRLMQS 301
Query: 392 Q------PFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIE 445
+ P + +D +PL YF++SSHNTYL G QV E +VE Y AL++G R +E
Sbjct: 302 RWGNVFKPGHESIFQDMDQPLTHYFVNSSHNTYLTGLQVKGEATVEGYISALRKGARLLE 361
Query: 446 IDIWQGDHG-PVVCH-GLFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMI 503
+D++ G+HG PV+ H F +SI L + ++ I++ AF TSPYP+I++LE H Q ++
Sbjct: 362 LDLFDGEHGEPVITHKRTFIESITLRNSLEAIKRTAFETSPYPVILTLENHVGFVQQAVM 421
Query: 504 TKIMKEILGDLIFVIPPNTS----LLSPEQLKNRIILKSKK 540
+ KEILGD ++ IPP S L SP +LK + +L+ KK
Sbjct: 422 ADLFKEILGDSLY-IPPKDSHRHPLSSPNKLKRKFLLRGKK 461
Score = 52.4 bits (124), Expect = 3e-06
Identities = 44/167 (26%), Positives = 77/167 (45%), Gaps = 19/167 (11%)
Query: 644 SLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNW 703
SLSE K + + + I + L++ YP LR SSN +P+ W G+Q VA N+
Sbjct: 523 SLSENKVYTMFE---AAVPIFTYTAERLVKSYPKGLRQDSSNMHPMVSWLCGIQSVAMNF 579
Query: 704 QTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKEIHKMKDIPVIMERLKREKIHIH 763
QT LN +F+++ + GYVLKP+ L + + + K+ +
Sbjct: 580 QTAGEELDLNAGLFRIN------GNCGYVLKPSCLLDGVDP--------RSMAKPKLKLG 625
Query: 764 LDVISGQML--SLQNCKILAPFVEIELITDNTMESLHLTNCLQPMGY 808
+ + S Q L S +I+ P+V +++ E+ T ++ G+
Sbjct: 626 IGLFSAQYLPKSEPGKEIIDPYVSVQIFGIPRDETKAKTRIIKDNGF 672
>CE12090 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 895
Score = 138 bits (348), Expect = 4e-32
Identities = 164/678 (24%), Positives = 272/678 (39%), Gaps = 106/678 (15%)
Query: 137 DLPLLKVTRRKRVRY-TFHIDQNTISWNNGKKL-----IYVDTIKDIRSGDMATNYMDMY 190
D L+ T R+ R+ + D + I W K I +D I++IR G
Sbjct: 58 DFVKLRGTNRQFRRFFSLDADLSYIRWTPTNKKPHKARIAIDEIREIRLGKNTELLRSSD 117
Query: 191 NVPCP-SRDLWCTIIYSVNKNRLKALHVIAEDAAVFKSFYETTVNLVNSRRKLMEDIAVP 249
V + +IIY N L + +DA + + T + + S + + P
Sbjct: 118 EVFTDLQEECLFSIIYGDNYETLDLIASSGDDANI----WVTGLMALTSNKYECK----P 169
Query: 250 NNEQFANIH--WQTSV----STKKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKA 303
++ QFA + W SV TKK + +F + + +R + N L + I A
Sbjct: 170 SSSQFATLRERWIESVFDEFDTKKNGHLDEQTAFKAILHINSRISHHRLTNKLKEVTIGA 229
Query: 304 DTNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEV-IS 362
+ + + F D K + RPE+ + + NKD + Q F+ QG V ++
Sbjct: 230 EESERGKIEKSHFVDLYKEIGTRPEVYFLMVRYANKD--YLSCQDLRLFLETEQGMVGVT 287
Query: 363 QTNAYKIFKKYCTADE-----LLDVEGLLKFLTK------QPFLQLFEEDYSRPLNEYFI 411
N + ++Y E L+ V+G FL P ++ D +P + YFI
Sbjct: 288 TDNCETLIEQYEPCSEARENNLMTVDGFTSFLFSPDCGVFDPNHRVVTMDMKQPFSRYFI 347
Query: 412 SSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQ-----GDHGPVVCHG-LFTQS 465
SSS +YL+ Q+ S + ++ AL++ CR +E DIW GD P+V +G T
Sbjct: 348 SSSRKSYLVEDQLGPSSS-DGFSSALKRNCRFLEFDIWDPNEADGDTEPMVQNGQTATSK 406
Query: 466 IPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIFVIPPNT--- 522
I + ++ IR++AF S YPL++ + +HC D+Q + ++ LG ++ +P N
Sbjct: 407 ITISSALRIIREFAFERSRYPLLLKVSVHCSTDWQKVAAMLIVTHLGTRLY-LPKNDPTN 465
Query: 523 -----SLLSPEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXXXXXXXXXXNDMRLIKKR 577
+ +P +NRI++ K K
Sbjct: 466 WDDEKNCPTPWDFQNRILIVGK------------------------------------KL 489
Query: 578 GLQKXXXXXXXXXXXXXXXXXKRNNKSLLLSTKIMISDKVHEISGIHGVRFRNFSLPESK 637
+R +K + L ++ SD V + + + P S
Sbjct: 490 DNPDTDSGEVSEEDDSLASTTRRKSKRIQLCKEL--SDLVPVFFNVKTLNDLLSTAPGST 547
Query: 638 TTT---HCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRFWKE 694
T + + S++E + L T + R + +R++P+ R SSN NP FW
Sbjct: 548 TMSSRKNLASVTESTCLRLM--HTYATEFGQATRNYCVRVFPNPSRVDSSNLNPQEFWNN 605
Query: 695 GVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKEIHKMKDIPVIMER 754
GVQMV N+QT L L F D GYVLKP ++ D+ V +R
Sbjct: 606 GVQMVCLNYQTPGLMMDLQEGKFS---DNGG---CGYVLKPQVMK------DDMFVPSDR 653
Query: 755 LKREKIHIHLDVISGQML 772
+ +HL ++SGQ L
Sbjct: 654 VPTSPQILHLRILSGQQL 671
>Hs4505871 [I] KOG1264 Phospholipase C
Length = 1252
Score = 138 bits (347), Expect = 5e-32
Identities = 96/281 (34%), Positives = 143/281 (50%), Gaps = 34/281 (12%)
Query: 292 SDNYLYALFIKADTNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMKNK-----------D 340
S +L F++ + + L +F +F F K L + I+ K+ D
Sbjct: 179 SAKFLKDKFVEIGAHKDEL-SFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPD 237
Query: 341 TKVVDFQSFYQFICDVQGEVISQTNAYKIFKKYC---------TADELLDVEGLLKFLTK 391
V F +F+ Q E +Q + K+ ++ TA+ L V+ L +L
Sbjct: 238 ASAVYLHDFQRFLIHEQQEHWAQ-DLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFS 296
Query: 392 -------QPFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCI 444
+ + + +D + PL+ Y+ISSSHNTYL G Q+ E S EAY R L+ GCRCI
Sbjct: 297 RENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCI 356
Query: 445 EIDIWQGDHG-PVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLM 502
E+D W G G PV+ HG T I +DVV+ I+ +AF+TS +P+I+S+E HC + Q
Sbjct: 357 ELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRH 416
Query: 503 ITKIMKEILGDLIFVIPPNTS---LLSPEQLKNRIILKSKK 540
+ K KE+ GDL+ P S L SP QL+ +II+K KK
Sbjct: 417 MAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKK 457
Score = 76.3 bits (186), Expect = 2e-13
Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 10/124 (8%)
Query: 665 KHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRN 724
K+N++ L R+YP R SSN++P R W G QMVA N+QT D Q+NHA+F ++
Sbjct: 976 KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLN---- 1031
Query: 725 SIWHSGYVLKPAHLRKEIHKMKDIPVIMERLKREKIHIHLDVISGQMLSLQNCKILAPFV 784
+GYVL+P +R E K P+ E ++ + + + V+ + L I PFV
Sbjct: 1032 --GRTGYVLQPESMRTE----KYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFV 1085
Query: 785 EIEL 788
E+E+
Sbjct: 1086 EVEI 1089
>Hs4505869 [I] KOG1264 Phospholipase C
Length = 1290
Score = 138 bits (347), Expect = 5e-32
Identities = 124/437 (28%), Positives = 199/437 (45%), Gaps = 51/437 (11%)
Query: 142 KVTRRKRVRYTFHIDQNTISWNNG----KKLIYVDTIKDIRSGDMATNYMDMYNVPC--P 195
K R +R + ++ I+W+ G + I + IK+IR G + ++ P P
Sbjct: 42 KSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRP 101
Query: 196 SRDLWCTIIYSVNKNRLKALHVIAEDAAVFKSFYETTVNL-VNSRRKLMED-IAVPNNEQ 253
+ I+Y + + RLK L + A E VN+ + LMED + P Q
Sbjct: 102 DQSHCFVILYGM-EFRLKTLSLQATS--------EDEVNMWIKGLTWLMEDTLQAPTPLQ 152
Query: 254 FANIHWQTSVSTKKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKADTNNNSL-LN 312
W + +D +S D+K + ++ + Y N + D S +
Sbjct: 153 IER--WLRKQFYSVDRNREDRISAKDLKNMLSQVN-YRVPNMRFLRERLTDLEQRSGDIT 209
Query: 313 FPEFQDFVKYL--KARPEIEIIWNQM------KNKDTKVVDFQSFYQFICDVQGEV--IS 362
+ +F + L A+ +++ + + + + V F QF+ D QGE+ +
Sbjct: 210 YGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVD 269
Query: 363 QTNAYKIFKKYCTADELLDVEGLLKFLTKQPFLQLFEED--------------YSRPLNE 408
+ + + D L ++E FL + +E+ + PL+
Sbjct: 270 RLQVQEFMLSFLR-DPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSH 328
Query: 409 YFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQGDHG-PVVCHG-LFTQSI 466
Y+ISSSHNTYL G Q E S+EAY R L+ GCRCIE+D W G G PV+ HG T I
Sbjct: 329 YWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKI 388
Query: 467 PLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIFVIPPNTS--- 523
DV+ TI+++AF+ S YP+I+S+E HC Q + + K++LGD + P S
Sbjct: 389 KFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEISADG 448
Query: 524 LLSPEQLKNRIILKSKK 540
L SP QLK +I++K KK
Sbjct: 449 LPSPNQLKRKILIKHKK 465
Score = 73.9 bits (180), Expect = 1e-12
Identities = 52/157 (33%), Positives = 74/157 (47%), Gaps = 22/157 (14%)
Query: 632 SLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRF 691
S PE+K + KKF+ ++NR L RIYP R SSN++P+
Sbjct: 982 SFPETKAEKYVNKAKGKKFL-------------QYNRLQLSRIYPKGQRLDSSNYDPLPM 1028
Query: 692 WKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKEIHKMKDIPVI 751
W G Q+VA N+QT D Q+N A+F H GYVL+P+ +R E D +
Sbjct: 1029 WICGSQLVALNFQTPDKPMQMNQALFMTGR------HCGYVLQPSTMRDEAFDPFDKSSL 1082
Query: 752 MERLKREKIHIHLDVISGQMLSLQNCKILAPFVEIEL 788
E I ++V+ + L I+ PFVEIE+
Sbjct: 1083 R---GLEPCAISIEVLGARHLPKNGRGIVCPFVEIEV 1116
>Hs18598741 [I] KOG1264 Phospholipase C
Length = 1265
Score = 138 bits (347), Expect = 5e-32
Identities = 96/281 (34%), Positives = 143/281 (50%), Gaps = 34/281 (12%)
Query: 292 SDNYLYALFIKADTNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMKNK-----------D 340
S +L F++ + + L +F +F F K L + I+ K+ D
Sbjct: 179 SAKFLKDKFVEIGAHKDEL-SFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPD 237
Query: 341 TKVVDFQSFYQFICDVQGEVISQTNAYKIFKKYC---------TADELLDVEGLLKFLTK 391
V F +F+ Q E +Q + K+ ++ TA+ L V+ L +L
Sbjct: 238 ASAVYLHDFQRFLIHEQQEHWAQ-DLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFS 296
Query: 392 -------QPFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCI 444
+ + + +D + PL+ Y+ISSSHNTYL G Q+ E S EAY R L+ GCRCI
Sbjct: 297 RENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCI 356
Query: 445 EIDIWQGDHG-PVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLM 502
E+D W G G PV+ HG T I +DVV+ I+ +AF+TS +P+I+S+E HC + Q
Sbjct: 357 ELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRH 416
Query: 503 ITKIMKEILGDLIFVIPPNTS---LLSPEQLKNRIILKSKK 540
+ K KE+ GDL+ P S L SP QL+ +II+K KK
Sbjct: 417 MAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKK 457
Score = 76.3 bits (186), Expect = 2e-13
Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 10/124 (8%)
Query: 665 KHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRN 724
K+N++ L R+YP R SSN++P R W G QMVA N+QT D Q+NHA+F ++
Sbjct: 976 KYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLN---- 1031
Query: 725 SIWHSGYVLKPAHLRKEIHKMKDIPVIMERLKREKIHIHLDVISGQMLSLQNCKILAPFV 784
+GYVL+P +R E K P+ E ++ + + + V+ + L I PFV
Sbjct: 1032 --GRTGYVLQPESMRTE----KYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFV 1085
Query: 785 EIEL 788
E+E+
Sbjct: 1086 EVEI 1089
>Hs14731274 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 1001
Score = 134 bits (338), Expect = 5e-31
Identities = 124/438 (28%), Positives = 200/438 (45%), Gaps = 52/438 (11%)
Query: 140 LLKVTRRKRVRYTFHI---DQNTISWNNGKK-----LIYVDTIKDIRSGDMATNYMDMYN 191
L KV R+ + + + D ++ W KK I + +IK++R+G +
Sbjct: 23 LKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGI 82
Query: 192 VPCPSRDLWCTIIYSVNKNRLKALHVIAEDAAVFKSFYETTVNLVNSRRKLMEDIAVPNN 251
S D ++IY N ++L ++A A V + + T + + S K D+ + ++
Sbjct: 83 SDQISEDCAFSVIYGEN---YESLDLVANSADV-ANIWVTGLRYLISYGKHTLDM-LESS 137
Query: 252 EQFANIHWQTSVSTKKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYAL-----------F 300
+ W VS + D D L LCN + C N L
Sbjct: 138 QDNMRTSW---VSQMFSEIDVDNLGHIT---LCNA--VQCIRNLNPGLKTSKIELKFKEL 189
Query: 301 IKADTNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEV 360
K+ + + EF + L RPEI + Q + + + +D + F+ QG
Sbjct: 190 HKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMMFLEAEQGVA 248
Query: 361 -ISQTNAYKIFKKYCTADE-----LLDVEGLLKFLTKQPFLQLFE-------EDYSRPLN 407
I++ + +I KY + E L ++G +L P +F+ +D +PL+
Sbjct: 249 HINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMS-PDCYIFDPEHKKVCQDMKQPLS 307
Query: 408 EYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG-DHGPVVCHG-LFTQS 465
YFI+SSHNTYL+ Q + Y RAL+ GCR +E+D+W G D+ PV+ G T
Sbjct: 308 HYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQ 367
Query: 466 IPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIFVIPPNTS-- 523
I V+ I KYAF S YPLI+ LE HC Q ++ + MK++LGD ++ PN
Sbjct: 368 IVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEES 427
Query: 524 -LLSPEQLKNRIILKSKK 540
L SP+ LK +I++K+KK
Sbjct: 428 YLPSPDVLKGKILIKAKK 445
Score = 66.6 bits (161), Expect = 2e-10
Identities = 44/133 (33%), Positives = 70/133 (52%), Gaps = 22/133 (16%)
Query: 666 HNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNS 725
+N+R L R++P +R SSN NP FWK G Q+VA N+QT L LN F+ +
Sbjct: 541 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQN----- 595
Query: 726 IWHSGYVLKPAHLRKEI-----HKMKDIPVIMERLKREKIHIHLDVISGQML-----SLQ 775
+ GYVL+PA +R+E+ + +P + +L +H+ +ISGQ S
Sbjct: 596 -GNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQL------LHIKIISGQNFPKPKGSGA 648
Query: 776 NCKILAPFVEIEL 788
++ P+V +E+
Sbjct: 649 KGDVVDPYVYVEI 661
>7296215 [I] KOG1265 Phospholipase C
Length = 1312
Score = 134 bits (336), Expect = 9e-31
Identities = 88/271 (32%), Positives = 137/271 (50%), Gaps = 30/271 (11%)
Query: 302 KADTNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMK-NKDTKVVDFQSFYQFICDVQ--- 357
K D+ + S F +F + KYL R E+E +++ + N K + +F+ Q
Sbjct: 199 KVDSISVSKFQFEDFYNLYKYLTQRSEVERLFDSIVGNSKRKCMSIAQLVEFLNKTQRDP 258
Query: 358 --GEVI----SQTNAYKIFKKY-----CTADELLDVEGLLKFLT--KQPFLQLFE----E 400
E++ + A ++ ++Y L ++G L++L P + + +
Sbjct: 259 RLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGDDNPIMAPSKLDLCD 318
Query: 401 DYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG-DHGPVVCH 459
D +P++ YFI+SSHNTYL G Q+ + SVE Y + L GCRC+E+D W G PV+ H
Sbjct: 319 DMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFWNGRTEEPVIVH 378
Query: 460 G-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIFVI 518
G F I +DV++ I + AF TS YP+I+S E HC Q I +EI GD++
Sbjct: 379 GYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFGDMLLDK 438
Query: 519 P-------PNTSLLSPEQLKNRIILKSKKTH 542
P PN L P L+ +II+K+KK H
Sbjct: 439 PLDSHPLEPNMDLPPPAMLRRKIIIKNKKKH 469
Score = 72.8 bits (177), Expect = 2e-12
Identities = 48/136 (35%), Positives = 71/136 (51%), Gaps = 16/136 (11%)
Query: 613 ISDKVHEISGIHGVRFRNFSLPESKTTTHCFSLS---EKKFINLDKDETQKLAINKHNRR 669
IS V+ + IH F +F E K C+ +S EK+ L K+ + + +N+
Sbjct: 599 ISALVNYVQPIH---FSSFENAEKKN--RCYEMSSFDEKQATTLLKE--RPIEFVNYNKH 651
Query: 670 HLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHS 729
L R+YP R+ SSNF P FW G Q+VA N+QT DL QLN +F+ + S
Sbjct: 652 QLSRVYPAGTRFDSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNA------RS 705
Query: 730 GYVLKPAHLRKEIHKM 745
GY+LKP +R+ ++
Sbjct: 706 GYLLKPEFMRRSDRRL 721
>CE02307 [I] KOG1264 Phospholipase C
Length = 1299
Score = 133 bits (334), Expect = 2e-30
Identities = 85/227 (37%), Positives = 121/227 (52%), Gaps = 29/227 (12%)
Query: 343 VVDFQSFYQFICDVQGEVIS--QTNAYKIFKKYCTADEL---------LDVEGLLKFLTK 391
VV FQ+F +F+ Q + ++ +T A + +Y D+ + V FL
Sbjct: 227 VVTFQNFLRFLDGKQFDELASNRTRALEFLNRYFQEDQAYFGDRNEPSMTVFEFCDFLFS 286
Query: 392 Q------PFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIE 445
+ P + D SRPL+ Y+I+SSHNTYL G Q+ E S++ Y +AL GCRCIE
Sbjct: 287 RENSLWDPTNEKVTHDMSRPLSHYWIASSHNTYLTGDQLRSESSLDCYAQALLMGCRCIE 346
Query: 446 IDIWQGDHGP--------VVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCK 496
+D W G P V+ HG T I L DV+ IR YAF+TS YP+I+S+E +C
Sbjct: 347 LDCWDGQKKPGSAEFIDIVIYHGYTMTSKILLRDVLHVIRHYAFVTSEYPVILSIEDNCS 406
Query: 497 KDYQLMITKIMKEILGDLIFVIPPN---TSLLSPEQLKNRIILKSKK 540
Q ++ + +K+ILGD + P N L SP LK +II+K KK
Sbjct: 407 VPAQRLLAQELKDILGDYLLTQPANREEKQLPSPAALKKKIIVKHKK 453
Score = 67.4 bits (163), Expect = 1e-10
Identities = 47/143 (32%), Positives = 71/143 (48%), Gaps = 13/143 (9%)
Query: 650 FINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLG 709
F+ D+ + + N R L R+YP+ R S+N++P+ W G MVA N+QT D
Sbjct: 959 FVEGKLDKLVEKGLLPFNSRKLSRVYPNGSRITSNNYSPVPMWNAGCHMVALNYQTGDKP 1018
Query: 710 QQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKEIHKMKDIPVIMERLKRE-KIHIHLDVIS 768
QLN F + GY+LKP ++ + P E+ I +++ VI
Sbjct: 1019 MQLNQGKFLAN------GRCGYLLKPDYMLTDDFD----PTNTEKFATAYPIRLNVQVIG 1068
Query: 769 GQMLSL--QNCKILAPFVEIELI 789
G+ LS +N I +PFVEIE+I
Sbjct: 1069 GRHLSRKDKNKGICSPFVEIEII 1091
>Hs20475709 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 757
Score = 132 bits (333), Expect = 2e-30
Identities = 75/190 (39%), Positives = 111/190 (57%), Gaps = 19/190 (10%)
Query: 369 IFKKYCTADE-----LLDVEGLLKFLTKQPFLQLFE-------EDYSRPLNEYFISSSHN 416
I KK+ ++E +L +EG F+ + P +F +D +PL Y+I+SSHN
Sbjct: 12 IIKKFEVSEENKVKNVLGIEGFTNFM-RSPACDIFNPLHHEVYQDMDQPLCNYYIASSHN 70
Query: 417 TYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQGDHG-PVVCHG-LFTQSIPLEDVVKT 474
TYL G Q++ + V+ Y R LQ+GCRC+E+D W G G PVV HG T I DVV+T
Sbjct: 71 TYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVET 130
Query: 475 IRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIFVIPPNT----SLLSPEQL 530
I K+AF+ + +P+I+S+E HC Q I + +K I GD + + +T L SP+ L
Sbjct: 131 INKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSL 190
Query: 531 KNRIILKSKK 540
K +I++K KK
Sbjct: 191 KGKILVKGKK 200
Score = 76.3 bits (186), Expect = 2e-13
Identities = 54/159 (33%), Positives = 81/159 (49%), Gaps = 18/159 (11%)
Query: 638 TTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRFWKEGVQ 697
TT + S SE + + + ++++ I +N++ L RIYP R SSNFNP+ +W G Q
Sbjct: 376 TTGNVLSFSETRAHQVVQQKSEQFMI--YNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 433
Query: 698 MVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKEIHKMKDIPVIMERLKR 757
+VA N+Q+ QLN A F+ + + GYVLKP + K + K+
Sbjct: 434 LVALNYQSEGRMMQLNRAKFKAN------GNCGYVLKPQQMCKGTFNPFSGDPLPANPKK 487
Query: 758 EKIHIHLDVISGQMLSL-------QNCKILAPFVEIELI 789
+ I L VISGQ L +I+ PFVE+E+I
Sbjct: 488 QLI---LKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 523
>CE20375 [I] KOG1265 Phospholipase C
Length = 896
Score = 129 bits (324), Expect = 2e-29
Identities = 107/362 (29%), Positives = 161/362 (43%), Gaps = 46/362 (12%)
Query: 405 PLNEYFISSSHNTYLMGKQVVDEVS-----VEAYTRALQQGCRCIEIDIWQG---DHGPV 456
P+N+YFI+SSHNTY G Q+V + VE Y +AL G RC+E+D+W D PV
Sbjct: 309 PINKYFINSSHNTYCSGNQLVYAIGHCSADVEMYRQALLSGSRCVELDMWDNKDKDGEPV 368
Query: 457 VCHG----LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILG 512
+ HG + I L++V + I++ AF TSPYP+I+S+E H + Q + +I +++ G
Sbjct: 369 ITHGPTAVMGMNEIGLKEVCEAIKECAFKTSPYPVILSIENHLGRKQQEKMVQIFRQVFG 428
Query: 513 DLIFVIP-PNTSLLS-----------PEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXX 560
+L+ P P+ L + PE LK++I++K+KK
Sbjct: 429 ELLLTGPLPDYPLYAKEGAGDVVYPPPELLKHKILIKAKKKRFEKQESRSRDSSSIDLQG 488
Query: 561 XXXXXXXXNDM---RLIKKRGLQKXXXXXXXXXXXXXXXXXKRNNKSLLLSTKIMISDKV 617
+M R + QK N T +S V
Sbjct: 489 SSIDLTEDEEMENERFNELTEEQKAAQLSELPEETTCSELSAITNYMQAYETSRGVSTVV 548
Query: 618 HEISGIHGVRFRNFSLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPH 677
+ + + S E+ T +C + ++DK + N+ + RIYP
Sbjct: 549 NLENATKDIVPCIVSADEN-TVYNCLRAN-----SIDK-------VQNLNKSKITRIYPK 595
Query: 678 MLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAH 737
R S+N+NP+ W G QMV+ N QT QLN+AMF +RN GYV KP
Sbjct: 596 ASRIYSTNYNPMIHWLTGSQMVSLNIQTNCSNMQLNYAMF----ERNG--GCGYVRKPDW 649
Query: 738 LR 739
LR
Sbjct: 650 LR 651
>7293213 [I] KOG1264 Phospholipase C
Length = 1236
Score = 128 bits (322), Expect = 4e-29
Identities = 87/244 (35%), Positives = 132/244 (53%), Gaps = 19/244 (7%)
Query: 306 NNNSLLNFP--EFQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQ-FICDVQGEVIS 362
+ + + NFP E Q V+ + + +E + + SF + F+ DV+ +V
Sbjct: 236 SGSGVANFPYSEDQQVVRPAELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQ- 294
Query: 363 QTNAYKIFKKYCTADELLD-VEGLLKFLTKQPFLQLFEEDYSRPLNEYFISSSHNTYLMG 421
+ Y T E +D + L + Q+F D + PL+ Y+I+SSHNTYL G
Sbjct: 295 --------EPYLTFPEFVDFLFSKQNDLWNSKYDQVFM-DMNLPLSSYWIASSHNTYLTG 345
Query: 422 KQVVDEVSVEAYTRALQQGCRCIEIDIWQG-DHGPVVCHG-LFTQSIPLEDVVKTIRKYA 479
Q E S EAY RAL+ GCRCIE+D W G D+ P + HG T I DV+KTI+ +A
Sbjct: 346 DQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFHGHTITSKIKFMDVIKTIKDHA 405
Query: 480 FITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIFVIPPNTS---LLSPEQLKNRIIL 536
F +S YP+I+S+E +C + Q + + + E+ GD++ P + + L SP QL+ +IIL
Sbjct: 406 FTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRNEQHLPSPYQLRRKIIL 465
Query: 537 KSKK 540
K KK
Sbjct: 466 KHKK 469
Score = 67.4 bits (163), Expect = 1e-10
Identities = 39/110 (35%), Positives = 57/110 (51%), Gaps = 19/110 (17%)
Query: 632 SLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIRF 691
S PE+K F + + F++ ++R + R+YP R SSNFNP+ F
Sbjct: 1004 SFPETKAEKQFFQQNTQLFLS-------------YHRNQISRVYPKGQRLDSSNFNPMPF 1050
Query: 692 WKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRKE 741
W G QM+A N+QT D QLN A F RN+ GY+LKP+ ++ +
Sbjct: 1051 WNVGSQMIALNYQTGDKAMQLNQAKF-----RNN-GQCGYILKPSFMKSD 1094
>Hs4505867 [I] KOG1265 Phospholipase C
Length = 1022
Score = 127 bits (318), Expect = 1e-28
Identities = 81/270 (30%), Positives = 135/270 (50%), Gaps = 31/270 (11%)
Query: 302 KADTNNNSLLNFPEFQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQ---- 357
K D + ++ +F + + + R +IE ++ ++ T + F+ + Q
Sbjct: 42 KNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPR 101
Query: 358 -GEVI----SQTNAYKIFKKYCTADEL-----LDVEGLLKFLTKQP----FLQLFE--ED 401
E++ A +I + Y ++L + +G ++L FL E ++
Sbjct: 102 LNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQE 161
Query: 402 YSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG---DHGPVVC 458
PL YFISSSHNTYL G+Q + SVE Y + L GCRC+E+D W G D P++
Sbjct: 162 MDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIIT 221
Query: 459 HG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDLIF- 516
HG I +DV++ I++ AF+TS YP+I+S E HC K Q ++K +++ GDL+
Sbjct: 222 HGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLK 281
Query: 517 ------VIPPNTSLLSPEQLKNRIILKSKK 540
+ P L SP LK +I++K+K+
Sbjct: 282 QALESHPLEPGRPLPSPNDLKRKILIKNKR 311
Score = 67.8 bits (164), Expect = 8e-11
Identities = 52/168 (30%), Positives = 81/168 (47%), Gaps = 21/168 (12%)
Query: 626 VRFRNFSLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSN 685
V+F+ F + E + + S S + + L +T + +N+R + RIYP R SSN
Sbjct: 422 VKFQGFHVAEERNIHYNMS-SFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSN 480
Query: 686 FNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLR---KEI 742
+ P FW G QMV+ N+QT DL QLN F+ + GY+LKP +R +
Sbjct: 481 YMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYN------GSCGYLLKPDFMRRPDRTF 534
Query: 743 HKMKDIPV--IMERLKREKIHIHLDVISGQMLSLQNCKILAPFVEIEL 788
+ PV ++ + VISGQ LS K + +VE+++
Sbjct: 535 DPFSETPVDGVIAAT------CSVQVISGQFLS---DKKIGTYVEVDM 573
>Hs11386139 [I] KOG1265 Phospholipase C
Length = 1234
Score = 124 bits (312), Expect = 5e-28
Identities = 84/259 (32%), Positives = 130/259 (49%), Gaps = 32/259 (12%)
Query: 316 FQDFVKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEV---------ISQTNA 366
F+ F+ L RP+I+ I ++ K + + FI Q + + + A
Sbjct: 213 FERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQA 272
Query: 367 YKIFKKYCTADELLD-----VEGLLKFLTKQ-----PFLQL-FEEDYSRPLNEYFISSSH 415
+ +KY + L+ +EG ++L + P L D ++PL+ YFI+SSH
Sbjct: 273 RLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSH 332
Query: 416 NTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG---DHGPVVCHGL-FTQSIPLEDV 471
NTYL Q+ SVE Y +AL GCRC+E+D+W+G + P + HG T +PL DV
Sbjct: 333 NTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDV 392
Query: 472 VKTIRKYAFITSPYPLIVSLEIHC-KKDYQLMITKIMKEILGDLIFVIP-------PNTS 523
++ I + AF TSPYP+I+S E H Q + + + I GD + + P P
Sbjct: 393 LEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVP 452
Query: 524 LLSPEQLKNRIILKSKKTH 542
L SP+ L RI++K+KK H
Sbjct: 453 LPSPQDLMGRILVKNKKRH 471
Score = 72.0 bits (175), Expect = 4e-12
Identities = 52/173 (30%), Positives = 88/173 (50%), Gaps = 19/173 (10%)
Query: 620 ISGIHGVRFRNFSLPESKTTTHCFSLSEKKFIN---LDKDETQKLAINKHNRRHLMRIYP 676
++ I V+F++F + CF +S F+ +++ + ++N++ L RIYP
Sbjct: 594 VNYIEPVKFKSFEAARKRNK--CFEMSS--FVETKAMEQLTKSPMEFVEYNKQQLSRIYP 649
Query: 677 HMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPA 736
R SSN+ P FW G Q+VA N+QT D+ QLN +F+ + SGY+LKP
Sbjct: 650 KGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYN------GRSGYLLKPE 703
Query: 737 HLRKEIHKMKDI-PVIMERLKREKIHIHLDVISGQMLSLQNCKILAPFVEIEL 788
+R+ VI++ + + + VISGQ LS + I +VE+++
Sbjct: 704 FMRRPDKSFDPFTEVIVDGIVANALRV--KVISGQFLSDRKVGI---YVEVDM 751
>Hs5453912 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 997
Score = 122 bits (305), Expect = 4e-27
Identities = 105/416 (25%), Positives = 192/416 (45%), Gaps = 33/416 (7%)
Query: 151 YTFHIDQNTISWNNGKK-----LIYVDTIKDIRSGDMATNYMDMYNVPCPSRDLWCTIIY 205
+T D + W KK + + IK+IR G + + D +I++
Sbjct: 37 FTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFTNNGLADQICEDCAFSILH 96
Query: 206 SVNKNRLKALHVIAEDAAVFKSFYETTVNLVNSRRKLMEDIAVPNNEQFANIHWQTSVST 265
N ++L ++A A V + + + + + SR K D + N+ W +V
Sbjct: 97 GEN---YESLDLVANSADV-ANIWVSGLRYLVSRSKQPLDF-MEGNQNTPRFMWLKTVF- 150
Query: 266 KKEDQDKDTLSFADVK-RLCNRYHIYCSDNYLYALFIKADTNNNSL---LNFPEFQDFVK 321
+ D D + + D L + + + + F + + L + EF +
Sbjct: 151 EAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFC 210
Query: 322 YLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEV-ISQTNAYKIFKKYCTADE-- 378
L RPE+ + Q+ +K+ + +D F+ QG I++ I ++Y ++E
Sbjct: 211 ELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGR 269
Query: 379 ---LLDVEGLLKFLTKQ------PFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVS 429
L ++G ++L P + +D ++PL+ Y+I++SHNTYL+ Q
Sbjct: 270 QKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPAD 329
Query: 430 VEAYTRALQQGCRCIEIDIWQG-DHGPVVCH-GLFTQSIPLEDVVKTIRKYAFITSPYPL 487
+ Y RAL+ GCR +E+D+ G D+ P++C+ T + V++ I K+AF+ S YPL
Sbjct: 330 INGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPL 389
Query: 488 IVSLEIHCKKDYQLMITKIMKEILGDLIFV---IPPNTSLLSPEQLKNRIILKSKK 540
I+ L HC Q ++ + MK++ G+ ++ +P + L SPE+LK II+K KK
Sbjct: 390 ILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKLKRMIIVKGKK 445
Score = 57.4 bits (137), Expect = 1e-07
Identities = 49/176 (27%), Positives = 84/176 (46%), Gaps = 17/176 (9%)
Query: 620 ISGIHGVRFRNFSLP-ESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHM 678
+S V++R+F L +S+ S SE + + + + +N++ L RIYP
Sbjct: 491 VSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV--NYNKKFLSRIYPSA 548
Query: 679 LRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHL 738
+R SSN NP FW G Q+VA N+QT L+ F + GYVL+P+ +
Sbjct: 549 MRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQN------GGCGYVLRPSIM 602
Query: 739 RKEI-HKMKDIPVIMERLKREKIHIHLDVISGQML-----SLQNCKILAPFVEIEL 788
R E+ + + I+ + + +H+ +ISGQ + ++ P+V IE+
Sbjct: 603 RDEVSYFSANTKGILPGV--SPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEI 656
>CE27569 [I] KOG1265 Phospholipase C
Length = 1387
Score = 117 bits (293), Expect = 9e-26
Identities = 88/293 (30%), Positives = 137/293 (46%), Gaps = 41/293 (13%)
Query: 266 KKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKADTNNNSLLNFPEFQDFVKYLKA 325
++E+ D D L+F +RL N+ C + LF+K +YL
Sbjct: 223 EREELDVDILTFEKFQRLYNKI---CPRTEVQELFVKLSGQK-------------EYLTK 266
Query: 326 RPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEVISQTNAYKIFKKYCTADELLDVEGL 385
I + + ++ + F F D Q +++ ++ KY D + +G
Sbjct: 267 ERLINFLNEEQRDPRLNEILFPFF-----DSQ-RIVALLKKHENDIKY-QEDGKMSGDGF 319
Query: 386 LKFLTKQP----FLQLFEE--DYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQ 439
L+FL FL E D +PL Y+I+SSHNTYL G+Q + S E Y + L
Sbjct: 320 LRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLS 379
Query: 440 GCRCIEIDIWQG----DHGPVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIH 494
GCRCIE+D W G P++ HG + +DV+ IR AF S +P+++S E H
Sbjct: 380 GCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENH 439
Query: 495 CKKDYQLMITKIMKEILGDLIFVIP-------PNTSLLSPEQLKNRIILKSKK 540
C K QL + K +I GD++ P P SL SP +L+ +I++K+K+
Sbjct: 440 CSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKR 492
Score = 71.6 bits (174), Expect = 5e-12
Identities = 61/190 (32%), Positives = 86/190 (45%), Gaps = 21/190 (11%)
Query: 624 HGVRFRNFSLPESKTTT-HCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYK 682
H V+F F + E+ H S SE + K + +N+R RIYP R
Sbjct: 722 HPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFV--NYNKRQSSRIYPKGARVD 779
Query: 683 SSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLR--- 739
SSNF P FW G QMV+ N+QT D+ QLN F+ + SGY+LKP LR
Sbjct: 780 SSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYN------GGSGYLLKPDFLRRPD 833
Query: 740 KEIHKMKDIPVIMERLKREKIHIHLDVISGQMLSLQNCKILAPFVEIEL--ITDNTMESL 797
+ + PV H + VISGQ LS + + +VE+E+ + +T+
Sbjct: 834 RTFDPFSESPVD----GVIAAHCSVRVISGQFLSDRK---IGTYVEVEMYGLPTDTIRKE 886
Query: 798 HLTNCLQPMG 807
H T + G
Sbjct: 887 HKTKVIPGNG 896
>CE23507 [I] KOG1265 Phospholipase C
Length = 1375
Score = 117 bits (293), Expect = 9e-26
Identities = 88/293 (30%), Positives = 137/293 (46%), Gaps = 41/293 (13%)
Query: 266 KKEDQDKDTLSFADVKRLCNRYHIYCSDNYLYALFIKADTNNNSLLNFPEFQDFVKYLKA 325
++E+ D D L+F +RL N+ C + LF+K +YL
Sbjct: 223 EREELDVDILTFEKFQRLYNKI---CPRTEVQELFVKLSGQK-------------EYLTK 266
Query: 326 RPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEVISQTNAYKIFKKYCTADELLDVEGL 385
I + + ++ + F F D Q +++ ++ KY D + +G
Sbjct: 267 ERLINFLNEEQRDPRLNEILFPFF-----DSQ-RIVALLKKHENDIKY-QEDGKMSGDGF 319
Query: 386 LKFLTKQP----FLQLFEE--DYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQ 439
L+FL FL E D +PL Y+I+SSHNTYL G+Q + S E Y + L
Sbjct: 320 LRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLS 379
Query: 440 GCRCIEIDIWQG----DHGPVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIH 494
GCRCIE+D W G P++ HG + +DV+ IR AF S +P+++S E H
Sbjct: 380 GCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENH 439
Query: 495 CKKDYQLMITKIMKEILGDLIFVIP-------PNTSLLSPEQLKNRIILKSKK 540
C K QL + K +I GD++ P P SL SP +L+ +I++K+K+
Sbjct: 440 CSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKR 492
Score = 71.6 bits (174), Expect = 5e-12
Identities = 61/190 (32%), Positives = 86/190 (45%), Gaps = 21/190 (11%)
Query: 624 HGVRFRNFSLPESKTTT-HCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYK 682
H V+F F + E+ H S SE + K + +N+R RIYP R
Sbjct: 722 HPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFV--NYNKRQSSRIYPKGARVD 779
Query: 683 SSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLR--- 739
SSNF P FW G QMV+ N+QT D+ QLN F+ + SGY+LKP LR
Sbjct: 780 SSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYN------GGSGYLLKPDFLRRPD 833
Query: 740 KEIHKMKDIPVIMERLKREKIHIHLDVISGQMLSLQNCKILAPFVEIEL--ITDNTMESL 797
+ + PV H + VISGQ LS + + +VE+E+ + +T+
Sbjct: 834 RTFDPFSESPVD----GVIAAHCSVRVISGQFLSDRK---IGTYVEVEMYGLPTDTIRKE 886
Query: 798 HLTNCLQPMG 807
H T + G
Sbjct: 887 HKTKVIPGNG 896
>At5g58690 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 568
Score = 115 bits (289), Expect = 3e-25
Identities = 105/405 (25%), Positives = 169/405 (40%), Gaps = 54/405 (13%)
Query: 351 QFICDVQGEV-ISQTNAYKIFKKY-CTADEL-------LDVEGLLKFL----TKQPFLQL 397
+F+ +VQ E + ++A KI ++ C + L+++ FL P
Sbjct: 46 RFLVEVQDETEVLVSDAEKIIERITCERHHITKFLRHTLNLDDFFSFLFSDDLNHPIDSK 105
Query: 398 FEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQGD--HGP 455
+D + PL+ YFI +SHN+YL G Q+ E S +AL++G R +E+D+W
Sbjct: 106 VHQDMASPLSHYFIYTSHNSYLTGNQINSECSDVPLIKALKRGVRALELDMWPNSTKDDI 165
Query: 456 VVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEILGDL 514
+V HG +T + L +++I+++AF S YP+I++LE H D Q ++MKEI D+
Sbjct: 166 LVLHGWAWTPPVELVKCLRSIKEHAFYASAYPVILTLEDHLTPDLQAKAAEMMKEIFMDM 225
Query: 515 IFVIPPNTSLL----SPEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXXXXXXXXXXND 570
++ P L SPE LK +I++ +K
Sbjct: 226 VYF--PEAGGLKEFPSPEDLKYKIVISTKPPKGSLRKDKDSESDASGKASSDVSADD--- 280
Query: 571 MRLIKKRGLQKXXXXXXXXXXXXXXXXXKRNNKSLLLSTKIMISDKVHEISGIHGVRFRN 630
+K + +N L ++++ + +G+
Sbjct: 281 ---------EKTEEETSEAKNEEDGFDQESSNLDFLTYSRLITIPSGNAKNGL------K 325
Query: 631 FSLPESKTTTHCFSLSEKKFINLDKDETQKLAINKHNRRHLMRIYPHMLRYKSSNFNPIR 690
+L SL E+KF K T+ K +L+RIYP R SSN+ P
Sbjct: 326 EALTIDNGGVRRLSLREQKF----KKATEMYGTEK----NLLRIYPKATRVNSSNYRPYN 377
Query: 691 FWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKP 735
W G QMVA N Q Y + H MF+ + GYV KP
Sbjct: 378 GWMYGAQMVAFNMQGYGRALWMMHGMFRGN------GGCGYVKKP 416
>Hs4758938 [I] KOG1265 Phospholipase C
Length = 1181
Score = 112 bits (281), Expect = 2e-24
Identities = 61/156 (39%), Positives = 88/156 (56%), Gaps = 12/156 (7%)
Query: 397 LFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIWQG---DH 453
L D ++PLN YFI+SSHNTYL Q S E Y + L GCRC+E+D W+G D
Sbjct: 309 LLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDE 368
Query: 454 GPVVCHGL-FTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKD-YQLMITKIMKEIL 511
P++ HG T I ++ ++ I + AF TSPYP+I+S E H Q + + + I
Sbjct: 369 EPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIF 428
Query: 512 GDLI-------FVIPPNTSLLSPEQLKNRIILKSKK 540
GD++ F + P L SPE L+ +I++K+KK
Sbjct: 429 GDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK 464
Score = 69.7 bits (169), Expect = 2e-11
Identities = 55/172 (31%), Positives = 85/172 (48%), Gaps = 17/172 (9%)
Query: 620 ISGIHGVRFRNFSLPESKTTTHCFS--LSEKKFINLDKDETQKLAINKHNRRHLMRIYPH 677
++ I +F +F K ++ S K + L K Q + +N+R + RIYP
Sbjct: 546 VNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFV---DYNKRQMSRIYPK 602
Query: 678 MLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAH 737
R SSN+ P FW G QMVA N+QT DL Q N A+F+ + SGY+LK
Sbjct: 603 GTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFN------GQSGYLLKHEF 656
Query: 738 LRKEIHKMKDIPVIMERLK-REKIHIHLDVISGQMLSLQNCKILAPFVEIEL 788
+R+ + P ++R+ + + VISGQ LS ++ + +VE+EL
Sbjct: 657 MRRPDKQFN--PFSVDRIDVVVATTLSITVISGQFLSERSVR---TYVEVEL 703
>At4g38530 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 526
Score = 103 bits (257), Expect = 1e-21
Identities = 105/428 (24%), Positives = 167/428 (38%), Gaps = 82/428 (19%)
Query: 344 VDFQSFYQFICDVQGE----------VISQTNAYKIFKKYCTADELLDVEGLLKFLTKQ- 392
+ F +F+ +VQGE + + +F + L+ + ++L
Sbjct: 1 MSFDELLRFVSEVQGERHAGLDYVQDIFHSVKHHNVFHHH----GLVHLNAFYRYLFSDT 56
Query: 393 ----PFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDI 448
P D PL+ YF+ + HN+YL G QV SVE +AL++G + IE+D+
Sbjct: 57 NSPLPMSGQVHHDMKAPLSHYFVYTGHNSYLTGNQVNSRSSVEPIVQALRKGVKVIELDL 116
Query: 449 WQGDHGPV--VCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITK 505
W G V HG T L+ + I+ AF S YP+I++LE H Q + K
Sbjct: 117 WPNPSGNAAEVRHGRTLTSHEDLQKCLTAIKDNAFHVSDYPVIITLEDHLPPKLQAQVAK 176
Query: 506 IMKEILGDLIF--VIPPNTSLLSPEQLKNRIILKSKKTHAVXXXXXXXXXXXXXXXXXXX 563
++ + ++F V SPE+LK +I++ +K
Sbjct: 177 MLTKTYRGMLFRRVSESFKHFPSPEELKGKILISTKP----------------------- 213
Query: 564 XXXXXNDMRLIKKRGLQKXXXXXXXXXXXXXXXXXKRNNKSLLLSTKIMISDKV--HEIS 621
K L+ + NK +L K M S+ V ++
Sbjct: 214 -----------PKEYLESKTVHTTRTPTVKETSWNRVANK-ILEEYKDMESEAVGYRDLI 261
Query: 622 GIHGVRFRNFSLPESKTTTHCFSLSEKKFINLDKDE--------TQKLAINKHNRRHLMR 673
IH ++ + C S +K I + DE T+ + + +R+L+R
Sbjct: 262 AIHAANCKD-------PSKDCLSDDPEKPIRVSMDEQWLDTMVRTRGTDLVRFTQRNLVR 314
Query: 674 IYPHMLRYKSSNFNPIRFWKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVL 733
IYP R SSN++P W G QMVA N Q + + MF+ + GYV
Sbjct: 315 IYPKGTRVDSSNYDPHVGWTHGAQMVAFNMQGHGKQLWIMQGMFRGN------GGCGYVK 368
Query: 734 KPAHLRKE 741
KP L E
Sbjct: 369 KPRILLDE 376
>At3g08510 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 581
Score = 100 bits (248), Expect = 1e-20
Identities = 77/232 (33%), Positives = 117/232 (50%), Gaps = 21/232 (9%)
Query: 324 KARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGE-VISQTNAYKIFKKYCTADELLDV 382
+A EI+ I+ + VD ++F+ DVQ + ++ +A I +A LL
Sbjct: 22 EAPREIKTIFEKYSENGVMTVDH--LHRFLIDVQKQDKATREDAQSIIN---SASSLLHR 76
Query: 383 EGL-----LKFL--TKQPFLQLFE--EDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAY 433
GL K+L P L L + D P++ YFI + HN+YL G Q+ + S
Sbjct: 77 NGLHLDAFFKYLFGDNNPPLALHKVHHDMDAPISHYFIFTGHNSYLTGNQLSSDCSEVPI 136
Query: 434 TRALQQGCRCIEIDIWQGDHGP--VVCHGL-FTQSIPLEDVVKTIRKYAFITSPYPLIVS 490
AL++G R IE+DIW + V HG+ T + L +K IR +AF S YP++V+
Sbjct: 137 IDALKKGVRVIELDIWPNSNKDDIDVLHGMTLTTPVGLIKCLKAIRAHAFDVSDYPVVVT 196
Query: 491 LEIHCKKDYQLMITKIMKEILGDLIFVIPPNTSLL---SPEQLKNRIILKSK 539
LE H D Q + +++ EI G+++F P SL SP LK RII+ +K
Sbjct: 197 LEDHLTPDLQSKVAEMVTEIFGEILFTPPVGESLKEFPSPNSLKRRIIISTK 248
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 14/109 (12%)
Query: 640 THCFSLSEKKF--INLDKDETQKLA------INKHNRRHLMRIYPHMLRYKSSNFNPIRF 691
T C + K ++L +++ +K A I + + +L+RIYP R SSN+NP+
Sbjct: 332 TECLKVDPDKVRRLSLSEEQLEKAAEKYAKQIVRFTQHNLLRIYPKGTRVTSSNYNPLVG 391
Query: 692 WKEGVQMVATNWQTYDLGQQLNHAMFQVSLDRNSIWHSGYVLKPAHLRK 740
W G QMVA N Q Y L MF+ + GY+ KP L K
Sbjct: 392 WSHGAQMVAFNMQGYGRSLWLMQGMFRAN------GGCGYIKKPDLLLK 434
>At3g55940 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 584
Score = 93.6 bits (231), Expect = 1e-18
Identities = 73/232 (31%), Positives = 115/232 (49%), Gaps = 23/232 (9%)
Query: 325 ARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGE-VISQTNAYKIFKKYCTADELLDVE 383
A EI+ +++ +K D +F+ DVQ + ++ A I + LL
Sbjct: 23 APAEIKTLFDNYSDKGLMTTDL--LLRFLIDVQKQDKATKEEAQDIVN---ASSSLLHRN 77
Query: 384 GL-----LKFL---TKQPFLQL-FEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYT 434
GL K+L T P L +D PL+ YFI + HN+YL G Q+ + S
Sbjct: 78 GLHLDAFFKYLFAVTNSPLSSLEVHQDMDAPLSHYFIYTGHNSYLTGNQLSSDCSELPII 137
Query: 435 RALQQGCRCIEIDIW--QGDHGPVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSL 491
AL++G R IE+DIW + G V HG T + L ++ IR++AF S YP++V+L
Sbjct: 138 EALKKGVRVIELDIWPNSDEDGIDVLHGRTLTSPVELIKCLRAIREHAFDVSDYPVVVTL 197
Query: 492 EIHCKKDYQLMITKIMKEILGDLIFVIPPNTSLL----SPEQLKNRIILKSK 539
E H Q + +++ +I G+++F PP+ L SP LK RI++ +K
Sbjct: 198 EDHLTPKLQAKVAEMVTDIFGEMLFT-PPSGECLKEFPSPAFLKKRIMISTK 248
>At5g58670 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 559
Score = 89.0 bits (219), Expect = 3e-17
Identities = 66/234 (28%), Positives = 109/234 (46%), Gaps = 19/234 (8%)
Query: 320 VKYLKARPEIEIIWNQMKNKDTKVVDFQSFYQFICDVQGEVISQTNAYK-IFKKYCTADE 378
VK + EI+ +++ D D +F+ VQGE + N K IF +
Sbjct: 17 VKSSEPPEEIKNLFHDYSQDDRMSAD--EMLRFVIQVQGETHADINYVKDIFHRLKHHGV 74
Query: 379 L----LDVEGLLKFLTKQ-----PFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVS 429
+ +EG ++L P + +D ++PL+ YF+ + HN+YL G Q+ S
Sbjct: 75 FHPRGIHLEGFYRYLLSDFNSPLPLTREVWQDMNQPLSHYFLYTGHNSYLTGNQLNSNSS 134
Query: 430 VEAYTRALQQGCRCIEIDIW---QGDHGPVVCHGLFTQSIPLEDVVKTIRKYAFITSPYP 486
+E +AL+ G R IE+D+W G V G T L+ + +++ AF S YP
Sbjct: 135 IEPIVKALRNGVRVIELDLWPNSSGKEAEVRHGGTLTSREDLQKCLNVVKENAFQVSAYP 194
Query: 487 LIVSLEIHCKKDYQLMITKIMKEILGDLIFVIPPNTSLL-SPEQLKNRIILKSK 539
++++LE H ++ K+ K G L T SPE LKN+I++ +K
Sbjct: 195 VVLTLEDHLT---PILQKKVAKTFGGSLFQCTDETTECFPSPESLKNKILISTK 245
>At5g58700 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 591
Score = 85.5 bits (210), Expect = 4e-16
Identities = 47/151 (31%), Positives = 80/151 (52%), Gaps = 4/151 (2%)
Query: 393 PFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTRALQQGCRCIEIDIW-QG 451
P ++ PL+ YFI + HN+YL G Q+ S AL++G R +E+D+W +G
Sbjct: 101 PIADQVHQNMDAPLSHYFIFTGHNSYLTGNQLSSNCSELPIADALRRGVRVVELDLWPRG 160
Query: 452 DHGPVVCHG-LFTQSIPLEDVVKTIRKYAFITSPYPLIVSLEIHCKKDYQLMITKIMKEI 510
V HG T+ + L +++I+ AF S YP+I++LE H Q + K++ +
Sbjct: 161 TDDVCVKHGRTLTKEVKLGKCLESIKANAFAISKYPVIITLEDHLTPKLQFKVAKMITQT 220
Query: 511 LGDLIFVIPPN--TSLLSPEQLKNRIILKSK 539
GD+++ SPE+LK +I++ +K
Sbjct: 221 FGDMLYYHDSQGCQEFPSPEELKEKILISTK 251
>At3g47290 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 531
Score = 75.1 bits (183), Expect = 5e-13
Identities = 45/168 (26%), Positives = 89/168 (52%), Gaps = 9/168 (5%)
Query: 380 LDVEGLLKFL----TKQPFLQLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEVSVEAYTR 435
L+++ L +FL P D PL+ YFI +S N+Y G V + S+
Sbjct: 81 LELDQLNEFLFSTKLNPPIGDQVHHDMHAPLSHYFIHTSLNSYFTGN-VFGKYSILPIIE 139
Query: 436 ALQQGCRCIEIDIWQGDHGPVVCHGL--FTQSIPLEDVVKTIRKYAFITSPYPLIVSLEI 493
AL+QG R +E+D+W G + F + + L++ + +I+++AF YPLI++ +
Sbjct: 140 ALEQGVRVVELDLWPDGRGSICVRPSWNFEKPLKLQECLDSIKEHAFTKCTYPLIITFKD 199
Query: 494 HCKKDYQLMITKIMKEILGDLIFVIPPNTSLL--SPEQLKNRIILKSK 539
K + Q T+++++ +++ P++ + SP+QL+N+I++ +
Sbjct: 200 GLKPELQSKATQMIQQTFNHMVYHHDPHSLEVFPSPQQLRNKILISRR 247
>At3g47220 [T] KOG0169 Phosphoinositide-specific phospholipase C
Length = 513
Score = 71.2 bits (173), Expect = 7e-12
Identities = 46/151 (30%), Positives = 84/151 (55%), Gaps = 7/151 (4%)
Query: 396 QLFEEDYSRPLNEYFISSSHNTYLMGKQVVDEV-SVEAYTRALQQGCRCIEIDIWQ-GDH 453
Q+ D + PL+ YFI +S +Y G V + S+E AL+QG R +E+D+ G
Sbjct: 103 QVRHRDMNAPLSHYFIHTSLKSYFTGNNVFGRLYSIEPIIDALKQGVRVVELDLLPFGKD 162
Query: 454 GPVVCHGL-FTQSIPLEDVVKTIRKYAFI-TSPYPLIVSLEIHCKKDYQLMITKIMKEIL 511
G V F + + L++ + I+++AF T YP+I++++ K D Q +T+++ +
Sbjct: 163 GICVRPKWNFEKPLELQECLDAIKQHAFTPTRSYPVIITIKDSLKPDLQSKVTQMIDQTF 222
Query: 512 GDLIFVIPPNTSL---LSPEQLKNRIILKSK 539
GD+++ P SL SP +L+N+I++ +
Sbjct: 223 GDMVYHEDPQQSLEEFPSPAELQNKILISRR 253
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,968,351
Number of Sequences: 60738
Number of extensions: 2155937
Number of successful extensions: 6004
Number of sequences better than 1.0e-05: 32
Number of HSP's better than 0.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 5815
Number of HSP's gapped (non-prelim): 99
length of query: 976
length of database: 30,389,216
effective HSP length: 116
effective length of query: 860
effective length of database: 23,343,608
effective search space: 20075502880
effective search space used: 20075502880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)