ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV0480 good O KOG4130 Posttranslational modification, protein turnover, chaperones Prenyl protein protease
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV0480 153272 152310 -321
(321 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YMR274c [O] KOG4130 Prenyl protein protease 192 4e-49
7295454 [O] KOG4130 Prenyl protein protease 87 4e-17
Hs4826976 [O] KOG4130 Prenyl protein protease 84 2e-16
SPAC1687.02 [O] KOG4130 Prenyl protein protease 80 3e-15
>YMR274c [O] KOG4130 Prenyl protein protease
Length = 315
Score = 192 bits (489), Expect = 4e-49
Identities = 106/310 (34%), Positives = 171/310 (54%), Gaps = 17/310 (5%)
Query: 8 VVAVYISLSYVVAVHTVSRDVNEFKIRRDDPKVIKARMKAVIALSAFHLTTIPLLLKYMN 67
+V +YIS+SYV+ ++ S+ +RD+P+ IK+RM+ + + +L +P L ++
Sbjct: 8 LVLLYISISYVLPLYATSQPEGS---KRDNPRTIKSRMQKLTIMLISNLFLVPFLQSQLS 64
Query: 68 GD----SIQNTLLRFGLLPGFLNETETGLPS-WVPFNYFKDSSRHLSLAIVLYSTPLLDS 122
S ++ L G++PG+ LP+ W + KD ++ +++ + LY P+LD
Sbjct: 65 STTSHISFKDAFLGLGIIPGYY----AALPNPWQFSQFVKDLTKCVAMLLTLYCGPVLDF 120
Query: 123 LLHYCFLPDKSYKDIISDICCEFSTIWGLRDYIFGPITEELFYTSMMLVAYLRLGDSSQY 182
+L++ P S I+ D EF IW R++IF PITEE+FYTSM+L YL L SQ
Sbjct: 121 VLYHLLNPKSS---ILEDFYHEFLNIWSFRNFIFAPITEEIFYTSMLLTTYLNLIPHSQL 177
Query: 183 DANYLTLIVPNLFGIAHVHHAFEQYSLGIMNLANIIFITLLQMSYTWLFGSFTNYLFLNS 242
L FG+AH HHA+EQ G M +I+ T Q+ YT LFG T ++F+ +
Sbjct: 178 SYQQLFWQPSLFFGLAHAHHAYEQLQEGSMTTVSILLTTCFQILYTTLFGGLTKFVFVRT 237
Query: 243 SGNLWSCILIHTFCNYMGLPQGNTFSKAYALVPIEKRSNLGTLFSSVWRLLYLPLLVISI 302
GNLW CI++H CN MG P + + + +V +K++ + S+W Y LLV+ +
Sbjct: 238 GGNLWCCIILHALCNIMGFPGPSRLNLHFTVV--DKKAGRISKLVSIWNKCYFALLVLGL 295
Query: 303 VLFKNNLTSL 312
+ K+ L +L
Sbjct: 296 ISLKDTLQTL 305
>7295454 [O] KOG4130 Prenyl protein protease
Length = 302
Score = 86.7 bits (213), Expect = 4e-17
Identities = 74/261 (28%), Positives = 123/261 (46%), Gaps = 28/261 (10%)
Query: 3 SRPADVVAVYISLSYVVAVHTV-SRDVNEFKIRRDDPKVIKARMKAVIALSAFHLTTIPL 61
S P VA +S +V+AV V S + K RD P +K R +V + + P
Sbjct: 21 SLPQIPVATSVSCCFVLAVLYVGSLYIWSTKHNRDHPTTVKRRFASVSMV----MLAAPF 76
Query: 62 LLKYMNGDSIQNTLLRFGLLPGFLNETETGLPSWVPFNYFKDSSRHLSLAIVLYSTPLLD 121
+ + + + + + P L GL V Y SL ++L+ P+
Sbjct: 77 FVYFFSSPELLSRVP----FPKLLGLRLEGLWQAVVIPY--------SLTVLLFLGPIFV 124
Query: 122 SLLHYCFLPDKSYKDIISDICCEFSTIWGLRDYIFGPITEELFYTSMMLVAYLRLGDSSQ 181
++ + +SY D+ S IW +R+++ P++EE + + M+ L+
Sbjct: 125 NMQNESV---RSYFDLDYWRGSFGSIIW-VRNHVIAPLSEEFVFRACMMPLILQ-----S 175
Query: 182 YDANYLTLIVPNLFGIAHVHHAFEQYSLGIMNLANIIFITLLQMSYTWLFGSFTNYLFLN 241
+ I P FG+AH+HH E+ SLG+ L+ + I L Q YT LFG ++ +LF
Sbjct: 176 FSPLVAVFITPLFFGVAHLHHIAERLSLGV-ELSTALLIGLFQFIYTTLFGFYSAFLFAR 234
Query: 242 SSGNLWSCILIHTFCNYMGLP 262
+G++ + IL+H FCN+MGLP
Sbjct: 235 -TGHVMAPILVHAFCNHMGLP 254
>Hs4826976 [O] KOG4130 Prenyl protein protease
Length = 329
Score = 84.3 bits (207), Expect = 2e-16
Identities = 77/257 (29%), Positives = 121/257 (46%), Gaps = 38/257 (14%)
Query: 13 ISLSYVVAVHTVSRDVNEFKIRRDDPKVIKARMKAVIALSAFHLTTIPLLLKYMNGDSIQ 72
++ SYV +++ V + ++ RD P VIK R +V+ +S+ + LL + + G
Sbjct: 45 LACSYVGSLY-----VWKSELPRDHPAVIKRRFTSVLVVSSLSPLCV-LLWRELTGIQPG 98
Query: 73 NTLLRFGLLPGFLNETETGLPSWVPFNYFKDSSRHLSLAIVLYSTPLLD-SLLHYCFLPD 131
+LL L GF E F + L L ++L+ PL+ S+ C L D
Sbjct: 99 TSLLT---LMGFRLE-----------GIFPAALLPLLLTMILFLGPLMQLSMDCPCDLAD 144
Query: 132 KSYKDIISDIC---CEFSTIWGLRDYIFGPITEELFYTSMML---VAYLRLGDSSQYDAN 185
K +++ C W LR+ + P+TEEL + + ML + LG +
Sbjct: 145 -GLKVVLAPRSWARCLTDMRW-LRNQVIAPLTEELVFRACMLPMLAPCMGLGPA------ 196
Query: 186 YLTLIVPNLFGIAHVHHAFEQYSLGIMNLANIIFITLLQMSYTWLFGSFTNYLFLNSSGN 245
P FG+AH HH EQ ++ NI Q SYT +FG++T +LF+ +G+
Sbjct: 197 --VFTCPLFFGVAHFHHIIEQLRFRQSSVGNIFLSAAFQFSYTAVFGAYTAFLFIR-TGH 253
Query: 246 LWSCILIHTFCNYMGLP 262
L +L H+FCNYMG P
Sbjct: 254 LIGPVLCHSFCNYMGFP 270
>SPAC1687.02 [O] KOG4130 Prenyl protein protease
Length = 271
Score = 80.5 bits (197), Expect = 3e-15
Identities = 67/258 (25%), Positives = 120/258 (45%), Gaps = 43/258 (16%)
Query: 8 VVAVYISLSYVVAVHTVSRDVNEFKIRRDDPKVIKARMKAVIALSAFHLTTIPLLLKYMN 67
+++ + + YVV+++T + R+DPKVI AR +V+ S+ L++
Sbjct: 5 LISFFFTAIYVVSLYTFPVARPRPSLNRNDPKVITARCISVLLASSVCCILTRLIIG--- 61
Query: 68 GDSIQNTLLRFGLLPGFLNETETGLPSWVPFNYFKDSSRHLSLAIVLYSTPLLDSLLHYC 127
PS F + D L +L++ + L+
Sbjct: 62 -------------------------PSLNVFTFPTDQV----LKSLLHAATIFIGPLYEV 92
Query: 128 FLPDKSYKDIISDI--CCEFSTIWGLRDYIFGPITEELFYTSMMLVAYLRLGDSSQYDAN 185
++ DK Y+ + C + W R+ I GP++EEL + ++ + +++ +
Sbjct: 93 WIVDKEYRLFFIHLKDCLSNAIAW--RNIIIGPLSEELTFRCCIVP----ICEAAGWSRL 146
Query: 186 YLTLIVPNLFGIAHVHHAFEQYSLGIMNLANIIFI-TLLQMSYTWLFGSFTNYLFLNSSG 244
+ + P LFG+AH+HH +E + L N + T++Q SYT +FG +T +LFL S+
Sbjct: 147 KIIFVAPLLFGMAHIHHTYE-FLLAYPNAYIAAALQTVVQFSYTTVFGWYTTHLFL-STH 204
Query: 245 NLWSCILIHTFCNYMGLP 262
+L+ L+H FCN MGLP
Sbjct: 205 SLFPSFLVHAFCNSMGLP 222
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.327 0.142 0.433
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,988,057
Number of Sequences: 60738
Number of extensions: 805549
Number of successful extensions: 2103
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2089
Number of HSP's gapped (non-prelim): 5
length of query: 321
length of database: 30,389,216
effective HSP length: 106
effective length of query: 215
effective length of database: 23,950,988
effective search space: 5149462420
effective search space used: 5149462420
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)