ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV0523 good F KOG1377 Nucleotide transport and metabolism Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV0523 164524 165201 226
(226 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YML106w [F] KOG1377 Uridine 5'- monophosphate synthase/orotate p... 363 e-100
YMR271c [F] KOG1377 Uridine 5'- monophosphate synthase/orotate p... 323 1e-88
SPBC725.15 [F] KOG1377 Uridine 5'- monophosphate synthase/orotat... 191 7e-49
Hs4507835 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate... 86 4e-17
CE18143 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate p... 84 1e-16
CE00638 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate p... 65 8e-11
7300695 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate p... 57 2e-08
>YML106w [F] KOG1377 Uridine 5'- monophosphate synthase/orotate
phosphoribosyltransferase
Length = 226
Score = 363 bits (932), Expect = e-100
Identities = 185/226 (81%), Positives = 210/226 (92%)
Query: 1 MPTALEDYQKNFLELAIESKALRFGEFTLKSGRVSPYFFNLGLFNTGKLLSNLATAYAIA 60
MP LEDYQKNFLELAIE +ALRFG F LKSGR SPYFFNLGLFNTGKLLSNLATAYAIA
Sbjct: 1 MPIMLEDYQKNFLELAIECQALRFGSFKLKSGRESPYFFNLGLFNTGKLLSNLATAYAIA 60
Query: 61 IIQSELKFDVIFGPAYKGIPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVG 120
IIQS+LKFDVIFGPAYKGIPLA+IVCVKLAEIGGSKFQ+++YAFNRKEAKDHGEGG IVG
Sbjct: 61 IIQSDLKFDVIFGPAYKGIPLAAIVCVKLAEIGGSKFQNIQYAFNRKEAKDHGEGGIIVG 120
Query: 121 AALKDQKILIIDDVMTAGTAINEAFEIIAKEEGKVVGSIIALDRQEVVNTEDTEVLSATQ 180
+AL++++ILIIDDVMTAGTAINEAFEII+ +G+VVGSIIALDRQEVV+T+D E LSATQ
Sbjct: 121 SALENKRILIIDDVMTAGTAINEAFEIISNAKGQVVGSIIALDRQEVVSTDDKEGLSATQ 180
Query: 181 SVSKRYDIPVLSIVNLSNIISYLDGRISVEEREKMEQYRQTYGASA 226
+VSK+Y IPVLSIV+L +II+YL+GRI+ EE+ K+EQY QTYGASA
Sbjct: 181 TVSKKYGIPVLSIVSLIHIITYLEGRITAEEKSKIEQYLQTYGASA 226
>YMR271c [F] KOG1377 Uridine 5'- monophosphate synthase/orotate
phosphoribosyltransferase
Length = 227
Score = 323 bits (828), Expect = 1e-88
Identities = 158/221 (71%), Positives = 192/221 (86%)
Query: 3 TALEDYQKNFLELAIESKALRFGEFTLKSGRVSPYFFNLGLFNTGKLLSNLATAYAIAII 62
T+LE+YQK FLEL +E KALRFG F L SGR SPYFFNL LFN+GKLL+NLATAYA AII
Sbjct: 6 TSLEEYQKTFLELGLECKALRFGSFKLNSGRQSPYFFNLSLFNSGKLLANLATAYATAII 65
Query: 63 QSELKFDVIFGPAYKGIPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVGAA 122
QSELKFDVIFGPAYKGIPLA+IVCVKLAEIGG+KFQ ++YAFNRK+ KDHGEGG IVGA+
Sbjct: 66 QSELKFDVIFGPAYKGIPLAAIVCVKLAEIGGTKFQGIQYAFNRKKVKDHGEGGIIVGAS 125
Query: 123 LKDQKILIIDDVMTAGTAINEAFEIIAKEEGKVVGSIIALDRQEVVNTEDTEVLSATQSV 182
L+D+++LIIDDVMTAGTAINEAFEII+ +G+VVG I+ALDRQEV++ D E SATQSV
Sbjct: 126 LEDKRVLIIDDVMTAGTAINEAFEIISIAQGRVVGCIVALDRQEVIHESDPERTSATQSV 185
Query: 183 SKRYDIPVLSIVNLSNIISYLDGRISVEEREKMEQYRQTYG 223
SKRY++PVLSIV+L+ ++ ++ R+S E++ +E YR+ YG
Sbjct: 186 SKRYNVPVLSIVSLTQVVQFMGNRLSPEQKSAIENYRKAYG 226
>SPBC725.15 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate
phosphoribosyltransferase
Length = 215
Score = 191 bits (485), Expect = 7e-49
Identities = 104/217 (47%), Positives = 138/217 (62%), Gaps = 5/217 (2%)
Query: 8 YQKNFLELAIESKALRFGEFTLKSGRVSPYFFNLGLFNTGKLLSNLATAYAIAIIQSELK 67
Y+ L A+E L+FG FTLKSGR SPYFFN G F G L LA AYA II +
Sbjct: 3 YKLELLRRALEHNVLKFGTFTLKSGRKSPYFFNSGNFTHGADLCALAEAYAETIIAMNVD 62
Query: 68 FDVIFGPAYKGIPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVGAALKDQK 127
FDVIFGPAYKGI LA+I VKL E G + +A+NRKEAK HGEGGN+VGA ++ +K
Sbjct: 63 FDVIFGPAYKGISLAAITAVKLYEKTGKSY---GFAYNRKEAKSHGEGGNLVGAEMEGKK 119
Query: 128 ILIIDDVMTAGTAINEAFEIIAKEEGKVVGSIIALDRQEVVNTEDTEVLSATQSVSKRYD 187
+L++DDV+TAGTAI EA + + K+ G ++ LDRQE ++ E E S + K +
Sbjct: 120 VLLLDDVITAGTAIREAISFLEPKHVKLAGIVLLLDRQERLDPEVNE--STIGRLKKELN 177
Query: 188 IPVLSIVNLSNIISYLDGRISVEEREKMEQYRQTYGA 224
+PV SI+ L +I+ + ++ E + M+ YRQ Y A
Sbjct: 178 LPVSSILTLDDIVDFTKSDLTAAESKAMDAYRQQYQA 214
>Hs4507835 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate
phosphoribosyltransferase
Length = 480
Score = 85.9 bits (211), Expect = 4e-17
Identities = 48/148 (32%), Positives = 80/148 (53%), Gaps = 10/148 (6%)
Query: 20 KALRFGEFTLKSGRVSPYFFNL-GLFNTGKLLSNLATAYAIAIIQSELKFDVIFGPAYKG 78
+A +FG+F LKSG SP + +L G+ + +LLS +A + + FD + G Y
Sbjct: 19 QAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTA 78
Query: 79 IPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVGAALKDQKILIIDDVMTAG 138
+PLA+++C + RKE KD+G + G + LII+DV+T+G
Sbjct: 79 LPLATVIC---------STNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSG 129
Query: 139 TAINEAFEIIAKEEGKVVGSIIALDRQE 166
+++ E E++ KE KV +I+ LDR++
Sbjct: 130 SSVLETVEVLQKEGLKVTDAIVLLDREQ 157
>CE18143 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate
phosphoribosyltransferase
Length = 227
Score = 84.3 bits (207), Expect = 1e-16
Identities = 62/209 (29%), Positives = 103/209 (48%), Gaps = 21/209 (10%)
Query: 9 QKNFLELAIESKALRFGEFTLKSGRVSPYFFNLG-LFNTGKLLSNLATAYAIAIIQSELK 67
+ +F E + + R GEF LKSG+++P + +L + ++ ++L A A I+ S LK
Sbjct: 30 ETDFFENLYQMECFRTGEFYLKSGQMTPIYIDLRRIMSSPRVLRMAAQAMCEKIVASNLK 89
Query: 68 FDVIFGPAYKGIPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVGAALKDQK 127
FD + G Y +PLA++V S +V RKEAK +G I G
Sbjct: 90 FDYVVGVPYAALPLATLV---------SDILNVPMLMKRKEAKAYGTKQLIEGVYQPGGT 140
Query: 128 ILIIDDVMTAGTAINEAFEIIAKEEGKVVGSIIALDRQEVVNTEDTEVLSATQSVSKRYD 187
+L+++DV+T+G +I E E I E V +I LDRQ+ AT ++++ +
Sbjct: 141 VLLVEDVVTSGESIRETAEAIRNENLLVTDAIAVLDRQQ----------GATANLAED-N 189
Query: 188 IPVLSIVNLSNIISYLDGRISVEEREKME 216
+ LS + + I+ L + + E K E
Sbjct: 190 LNFLSFLTMEKILDGLITKNEMTEERKHE 218
>CE00638 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate
phosphoribosyltransferase
Length = 497
Score = 65.1 bits (157), Expect = 8e-11
Identities = 42/159 (26%), Positives = 78/159 (48%), Gaps = 9/159 (5%)
Query: 9 QKNFLELAIESKALRFGEFTLKSGRVSPYFFNLG-LFNTGKLLSNLATAYAIAIIQSELK 67
++N L +++ +FGEF LKSG++SP + +L F LL ++ A + + SE++
Sbjct: 14 KRNLLRQMLKASVFKFGEFQLKSGQISPIYIDLRECFGHPGLLMLISEAISKQVEISEVQ 73
Query: 68 FDVIFGPAYKGIPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVGAALKDQK 127
+ + G Y +P AS+ + RKEAK +G I G + +
Sbjct: 74 YAGVLGIPYAALPYASVAA--------GNYLKKPLLIVRKEAKSYGTKKLIEGLYQPNDR 125
Query: 128 ILIIDDVMTAGTAINEAFEIIAKEEGKVVGSIIALDRQE 166
+++I+DV+T G +I + +++ E LDR++
Sbjct: 126 LILIEDVVTTGGSILDVVKVLHTENLVASDVFCILDREQ 164
>7300695 [F] KOG1377 Uridine 5'- monophosphate synthase/orotate
phosphoribosyltransferase
Length = 493
Score = 57.0 bits (136), Expect = 2e-08
Identities = 40/150 (26%), Positives = 72/150 (47%), Gaps = 10/150 (6%)
Query: 18 ESKALRFGEFTLKSGRVSPYFFNLGLF-NTGKLLSNLATAYAIAIIQSELKFDVIFGPAY 76
E A +FG+F +K G SP +F+L + + ++ ++ I +L + G Y
Sbjct: 18 EINAFKFGDFKMKVGINSPVYFDLRVIVSYPDVMQTVSDLLVEHIKDKQLSAKHVCGVPY 77
Query: 77 KGIPLASIVCVKLAEIGGSKFQDVKYAFNRKEAKDHGEGGNIVGAALKDQKILIIDDVMT 136
+PLA+IV V+ Q RKEAK +G + G LI++DV+T
Sbjct: 78 TALPLATIVSVQ---------QGTPMLVRRKEAKAYGTKKLVEGIFNAGDTCLIVEDVVT 128
Query: 137 AGTAINEAFEIIAKEEGKVVGSIIALDRQE 166
+G++I + + E V +++ +DR++
Sbjct: 129 SGSSILDTVRDLQGEGIVVTDAVVVVDREQ 158
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.136 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,839,858
Number of Sequences: 60738
Number of extensions: 461730
Number of successful extensions: 1126
Number of sequences better than 1.0e-05: 7
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1114
Number of HSP's gapped (non-prelim): 7
length of query: 226
length of database: 30,389,216
effective HSP length: 103
effective length of query: 123
effective length of database: 24,133,202
effective search space: 2968383846
effective search space used: 2968383846
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)