ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV0783 good K KOG3786 Transcription RNA polymerase II assessory factor Cdc73p
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV0783 256974 255871 -368
(368 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR418c [K] KOG3786 RNA polymerase II assessory factor Cdc73p 364 e-100
SPBC17G9.02c [K] KOG3786 RNA polymerase II assessory factor Cdc73p 154 2e-37
At3g22590 [K] KOG3786 RNA polymerase II assessory factor Cdc73p 86 9e-17
7299132 [K] KOG3786 RNA polymerase II assessory factor Cdc73p 74 3e-13
CE24942 [K] KOG3786 RNA polymerase II assessory factor Cdc73p 69 1e-11
Hs16506830 [K] KOG3786 RNA polymerase II assessory factor Cdc73p 66 9e-11
7303281 [K] KOG3786 RNA polymerase II assessory factor Cdc73p 55 2e-07
>YLR418c [K] KOG3786 RNA polymerase II assessory factor Cdc73p
Length = 393
Score = 364 bits (935), Expect = e-100
Identities = 194/396 (48%), Positives = 253/396 (62%), Gaps = 39/396 (9%)
Query: 3 LGELREYLGKDKSNHDLKLISGDGELIDDIVLAKSVVV---NGENKD---LDELTEFSLE 56
L LRE+L K+ L L + +G+ DDI A V +G +D L+E TE ++
Sbjct: 5 LDRLREHL---KNGDKLVLKNNEGQSTDDITKATMVETLSSDGSTQDSFPLNEETEIEID 61
Query: 57 GKPVPLRVVIHCWLHRNSSAADYLADCRAKNFTNVSFLHRNDLIQWLSGESETSQYVSTS 116
G V LR+++HCW++++SSAADYLADC+ K TNVSFL R DLI WLSG +E+SQY+
Sbjct: 62 GSLVQLRIIVHCWMNKDSSAADYLADCQNKQLTNVSFLQRTDLINWLSGNTESSQYLKAP 121
Query: 117 EEKSELPDKSALQSKE-----SNAGKAASAQVKG----------EVFPYERAILDHNSSL 161
+K E DK +++K S SA ++ E +ER ++DHNS+L
Sbjct: 122 GQKGETSDKVDIENKTLAGELSTVKSTTSASLENDSEVSDPVVVETMKHERILVDHNSAL 181
Query: 162 RGSKPTNFQYLIKEAELKLVHXXXXXXXXXXXXXXXXXPDH-------SKAKPSS---QK 211
RG+KP NF YLIK+AELKLV P H SK SS +K
Sbjct: 182 RGAKPINFGYLIKDAELKLVQSIKGSLRGSKLP-----PGHKGAHGRISKTNGSSGGPRK 236
Query: 212 DXXXXXXXXXXXXFTIANIRQFLEESKYVNPKDLPISHKDLVTAVKKFDRISRPIRFLIV 271
D T+ANI+QFL ESKYVNP++LP LV K F+RISRPIRF+IV
Sbjct: 237 DPIILIPSAASSILTVANIKQFLLESKYVNPRNLPSVPNGLVNIEKNFERISRPIRFIIV 296
Query: 272 NNTKLFTQPEYWDRVVAIFTTGHEWQFTNYQWSNPAELFQHCKGFYFHFSGDLVPRNAEQ 331
+NT++FT+PEYWDRVVAIFTTGH WQF NYQW++P ELFQ CKG+YFHF+GD VP++ +Q
Sbjct: 297 DNTRMFTKPEYWDRVVAIFTTGHTWQFNNYQWNSPQELFQRCKGYYFHFAGDSVPQHVQQ 356
Query: 332 WNVQKLELDKNKRFKDIEVSRFFWTIIERELLARGY 367
WNV+K+ELDKNKRFKD+EV R+FW +E+EL++RGY
Sbjct: 357 WNVEKVELDKNKRFKDVEVVRYFWHSLEKELISRGY 392
>SPBC17G9.02c [K] KOG3786 RNA polymerase II assessory factor Cdc73p
Length = 371
Score = 154 bits (389), Expect = 2e-37
Identities = 101/329 (30%), Positives = 153/329 (45%), Gaps = 34/329 (10%)
Query: 47 LDELTEF-SLEGKP-VPLRVVIHCWLHRNSSAADYLADCRAKNFTNVSFLHRNDLIQWLS 104
+DE T+F LE LR V WL R++S A+Y+ C N++FL R DLI WL
Sbjct: 49 IDEPTKFIKLENDSHFSLRSVYFAWLLRDTSIAEYIQQCSELGIQNLTFLERTDLISWLE 108
Query: 105 GESETSQYVSTSEEKSELPDKSALQSKESNAGKAASAQVKGEVFPYERAILDHNSSLRGS 164
G S++ + + K P+ S + + ++ +F R + +HNS L G
Sbjct: 109 GSSDSEHIIGLEKPK---PEGSTDAATSMDVDLHKKSEEVNWLFENTRTVSNHNSVLHGI 165
Query: 165 KPTNFQYLIKEAELKLVHXXXXXXXXXXXXXXXXXPDHSKAKPSSQKDXXXXXXXXXXXX 224
KP +F L K+ L +H + + +D
Sbjct: 166 KPIDFISLRKDV-LDYIHANKATASAHAD-------EQERPAKKRNRDPIILLSPSASSL 217
Query: 225 FTIANIRQFLEESKYVNPKD-------------LPISHKDLVTAVKKFDRISRPIRFLIV 271
T+ NI++FLEE +V P + + +SHK ++ KF + RF+IV
Sbjct: 218 LTMHNIKKFLEEGIFVPPAEAAHAAGGGRGPELIALSHK---SSNSKFGTM----RFIIV 270
Query: 272 NNTKLFTQPEYWDRVVAIFTTGHEWQFTNYQWSNPAELFQHCKGFYFHFSGDLVPRNAEQ 331
T+ F +P+YWDRVV +FTTG WQF +Y+WS P +LF H KGF + GD
Sbjct: 271 EGTEKF-KPDYWDRVVCVFTTGQAWQFRDYKWSEPHQLFHHVKGFLVQYVGDPPHPATHD 329
Query: 332 WNVQKLELDKNKRFKDIEVSRFFWTIIER 360
WNV+ + +++ +R D EV W +ER
Sbjct: 330 WNVEGIFVERLRRHTDREVVSQLWDKLER 358
>At3g22590 [K] KOG3786 RNA polymerase II assessory factor Cdc73p
Length = 415
Score = 85.9 bits (211), Expect = 9e-17
Identities = 47/149 (31%), Positives = 78/149 (51%), Gaps = 7/149 (4%)
Query: 226 TIANIRQFLEESKY----VNPKDLPISHKDLVTAVKKFDRI-SRPIRFLIVNNTKLFTQP 280
TI N+++FLE+ Y V K++ D +T KKF R R + V + +P
Sbjct: 266 TIYNVKEFLEDGVYIPNDVKAKEMKGLKPDCITVQKKFSRDRERVVTAYEVRDKPSALKP 325
Query: 281 EYWDRVVAIFTTGHEWQFTNYQWSNPAELFQHCKGFYFHFSGDLV--PRNAEQWNVQKLE 338
+ WDRVVA+F G +WQF ++ + + E+F GF+ F D + + +QWNV+ +
Sbjct: 326 DDWDRVVAVFVLGKDWQFKDWPFKDHVEIFNKIIGFFLRFEDDSIESAKTVKQWNVKIIS 385
Query: 339 LDKNKRFKDIEVSRFFWTIIERELLARGY 367
+ KNKR +D + W +E + +R +
Sbjct: 386 ISKNKRHQDRAAALEVWEKLEEFVRSRSH 414
>7299132 [K] KOG3786 RNA polymerase II assessory factor Cdc73p
Length = 538
Score = 73.9 bits (180), Expect = 3e-13
Identities = 39/138 (28%), Positives = 73/138 (52%), Gaps = 5/138 (3%)
Query: 226 TIANIRQFLEESKYVNPKDLPIS--HKDLVTAVKKFDRISRPIRFLIVNNTKLFTQPEYW 283
T+ N + L+E ++++ D + ++ +++ R ++ + + +++N +Q E W
Sbjct: 392 TMLNAKDILQELRFMSTSDKKLQGCQRECEVLLQR-KRNNQTVSYRVIDNPTKLSQQE-W 449
Query: 284 DRVVAIFTTGHEWQFTNYQWS-NPAELFQHCKGFYFHFSGDLVPRNAEQWNVQKLELDKN 342
RVVA+F G +WQF + W NP ++F F+ FS + N E+W+V L L +N
Sbjct: 450 QRVVAVFVMGPQWQFKGWPWEGNPVDIFSKICAFHLCFSEMKLDSNVERWSVTLLRLSQN 509
Query: 343 KRFKDIEVSRFFWTIIER 360
KR D V FW +++
Sbjct: 510 KRHMDRAVLSKFWETLDK 527
>CE24942 [K] KOG3786 RNA polymerase II assessory factor Cdc73p
Length = 574
Score = 68.9 bits (167), Expect = 1e-11
Identities = 47/153 (30%), Positives = 69/153 (44%), Gaps = 23/153 (15%)
Query: 229 NIRQFLEESKYV-----------NPKDLPISH-KDLVTAV--KKFDRISRPIRFLI---- 270
N+R L+ YV P DL I K+ VT+ KK ++ ++F I
Sbjct: 407 NVRDILQNFSYVPVDQRRKETNKKPVDLAIQRQKNGVTSKNSKKKQKLHFNLKFEIDSDN 466
Query: 271 ---VNNTKLFTQPEYWDRVVAIFTTGHEWQFTNYQWS-NPAELFQHCKGFYFHFSGDLVP 326
++N + + WDRV+A+F G WQF ++W+ NP ++F H F+FH D
Sbjct: 467 IRVIDNAEKLANDD-WDRVIAVFVMGVAWQFKGWKWNGNPTDIFTHIPAFHFHVDQDKPV 525
Query: 327 RNAEQWNVQKLELDKNKRFKDIEVSRFFWTIIE 359
QWNV K+ + KR D W IE
Sbjct: 526 AQVMQWNVHKIPVSATKRHMDKARFSQVWETIE 558
>Hs16506830 [K] KOG3786 RNA polymerase II assessory factor Cdc73p
Length = 531
Score = 65.9 bits (159), Expect = 9e-11
Identities = 35/111 (31%), Positives = 56/111 (49%), Gaps = 5/111 (4%)
Query: 262 ISRPIRFLIVNNTKLFTQPEYWDRVVAIFTTGHEWQFTNYQW----SNPAELFQHCKGFY 317
IS + + +V+ L P+ WDRVVA+F G WQF + W +P ++F K F+
Sbjct: 419 ISVTVPYRVVDQP-LKLMPQDWDRVVAVFVQGPAWQFKGWPWLLPDGSPVDIFAKIKAFH 477
Query: 318 FHFSGDLVPRNAEQWNVQKLELDKNKRFKDIEVSRFFWTIIERELLARGYH 368
+ + N ++W+V LEL +KR D V FW ++R ++ H
Sbjct: 478 LKYDEVRLDPNVQKWDVTVLELSYHKRHLDRPVFLRFWETLDRYMVKHKSH 528
>7303281 [K] KOG3786 RNA polymerase II assessory factor Cdc73p
Length = 359
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/151 (24%), Positives = 64/151 (41%), Gaps = 25/151 (16%)
Query: 226 TIANIRQFLEESKY-------------VNPKDLPISHKDLVTAVKKFDRISRPIRFLIVN 272
++ NI+ LEE Y PK++ + H+ + + + +++
Sbjct: 207 SLNNIKTLLEELHYEPERNGRQSNPPECRPKEVIVEHRFQ----------NELVSYRVID 256
Query: 273 NTKLFTQPEYWDRVVAIFTTGHEWQFTNY-QWSNPAELFQHCKGFYFHFSGDLVPRNAEQ 331
N T P WDRVVA+F G +WQF + ++PA +F F+ HF + +
Sbjct: 257 NVTNLT-PVEWDRVVAVFAMGPKWQFKGWPDGADPAAIFHKVCAFHLHFRNTPMCPELTK 315
Query: 332 WNVQKLELDKNKRFKDIEVSRFFWTIIEREL 362
V L L +R D + FW ++R +
Sbjct: 316 LQVHSLALSPTERHSDSGIIMEFWNRVDRHM 346
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,102,466
Number of Sequences: 60738
Number of extensions: 870982
Number of successful extensions: 2304
Number of sequences better than 1.0e-05: 7
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2289
Number of HSP's gapped (non-prelim): 9
length of query: 368
length of database: 30,389,216
effective HSP length: 108
effective length of query: 260
effective length of database: 23,829,512
effective search space: 6195673120
effective search space used: 6195673120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)