ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1212 good R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1212 400541 402892 784
(784 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR018w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 407 e-113
YFR022w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 323 6e-88
SPAC31A2.12 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 184 3e-46
SPCC584.15c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 149 1e-35
YGR068c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 108 2e-23
SPBC2D10.04 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 62 3e-09
YJL084c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 57 1e-07
YKR021w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 51 8e-06
>YOR018w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 837
Score = 407 bits (1047), Expect = e-113
Identities = 281/824 (34%), Positives = 395/824 (47%), Gaps = 77/824 (9%)
Query: 3 KTSRSLSLFDIRLEGTDHDVIVVKGTVDEAPXXXXXXXXXXXXREPIYAKKISLTLYGVI 62
+ S+ LFDIRL D+DV+++KG DEA EPI K ++L L+G +
Sbjct: 7 RPSKEPLLFDIRLRNLDNDVLLIKGPPDEASSVLLSGTIVLSITEPIQIKSLALRLFGRL 66
Query: 63 KLNVTTMVQGPRGPAPRNVKYDRRFYELSLDDIDLHPHLVD-------GSTVKKPLSRTN 115
+LN+ T++Q GP R K++R Y DD ++ + + G S TN
Sbjct: 67 RLNIPTVLQTVHGPHKRYSKFERNIYSHFWDDFNIKSYFQNLYDNHNNGKITISSKSSTN 126
Query: 116 XXXX---XXXXXXXXXXXXKNFASSASHASVLPEGNYVFPFSTILPGSLTESVEGLPNAT 172
S++ + L +GNY FPFS I+PGSL ESVEGLPNA
Sbjct: 127 LAALPKRKRALSTASLISSNGQTSASKNYHTLVKGNYEFPFSAIIPGSLVESVEGLPNAA 186
Query: 173 VFYKLQATLERGKFASDISTKKHVRVVRTLTPDALELFETVAVDNTWPQKVDYSISVPSK 232
V Y L+AT+ER K D+ KKH+RV+RTL DA+EL ETV+VDN+WP+KVDY+IS+P+K
Sbjct: 187 VTYALEATIERPK-QPDLICKKHLRVIRTLAIDAVELSETVSVDNSWPEKVDYTISIPTK 245
Query: 233 AIAIGSSTPINIMXXXXXXXXXXXXXXXSLVEXXXXXXXXXXXXGADRTILKVKIQDPLH 292
AIAIGSST INI+ SLVE +R + K+K++DPL
Sbjct: 246 AIAIGSSTMINILIVPILKGLKLGPVRISLVENSQYCGSYGGVINQERMVAKLKLKDPLK 305
Query: 293 HI---------NNGEYDATNTTEFDFQDKWEINTSVRIPPNLSKCVQDCLILTNIKVRHK 343
H+ N + +T +FQDKWE+ + IP +L+KC QDC IL+NIKVRHK
Sbjct: 306 HVAQIKKKRSLNEAADEGVDTDTGEFQDKWEVRALLNIPASLTKCSQDCRILSNIKVRHK 365
Query: 344 LKFVIALVNPDGHISELRASLPVQLFISPFVTVAVRNAXXXXXXXXX------------- 390
+KF I+L+NPDGHISELRA+LPVQLFISPFV V V+ +
Sbjct: 366 IKFTISLLNPDGHISELRAALPVQLFISPFVPVNVKTSDVIERTLKTFGPSYQVTSQHDN 425
Query: 391 --------------XXXXXXXEALEKDDLMFAHSNSEVNLNSVDIALNNDASAGPNTSLF 436
AL+ + S S +N+NS D A TSL
Sbjct: 426 SFSSKNFVDDSEEDVIFQRSASALQLSSMPTIVSGSTLNINSTDAEATAVADTTMVTSLM 485
Query: 437 APPNYGNHVYDRLWNNIMVEDTPVNSGTQSPAEFNQPPTLSHSSDVXXXXXXXXXXXXXX 496
PPNYGNHVYDR++ + ED S + S E + +
Sbjct: 486 VPPNYGNHVYDRVYGEVTNEDETSASASSSAVESQAIHNIQNLYISDSNNSNNPILAPNP 545
Query: 497 XMEEPDGSGLNLDTQVPSRSALATPLSLQDVPSQLRVNDYFTLNSSNRNNHSVLNVPSHL 556
++ D S N D SR +L V S L +++ + NS + N ++ + + + L
Sbjct: 546 QIKIEDDSLNNCD----SRGDSVNNSNLNLVNSNLTISENWNNNSPSANRYNNI-INAGL 600
Query: 557 RSPSQMDSPGFDYLSRANSFEFKAGSPS-RNDWEISSLSRVPSYDNAMKTASTMGELPPA 615
SPS +P F +LSR NS+ + S S +ND E++ LSRVPSYD AMK+ +LPPA
Sbjct: 601 NSPSL--TPSFAHLSRRNSYSRQTSSTSLKNDLELTDLSRVPSYDKAMKSDMIGEDLPPA 658
Query: 616 YPSDGDALNGGSTTFSVGSLERPKELHHRCQPEMHHCAHSKISPSMLIXXXXXXXXXLTH 675
YP + + LERP+ LHH+ + S S + L +
Sbjct: 659 YPEEELGVQENKKI----ELERPQILHHKSTSSLLPLPGSSKSSNNLKRSSSRTHLSHSP 714
Query: 676 MYADHHERELEDSQTTK-HAGRPFLAKSTSTSALKNTASKHFGFSMTPLSHIARSATPPA 734
+ ++ + Q + + F + TSA +T S+HF F+MT
Sbjct: 715 LPRNNSGSSVSLQQLARNNTDSSFNLNLSFTSAKSSTGSRHFPFNMT------------T 762
Query: 735 KFSPLSNSSNGIQTPKAVSNRNKVTSGSNKHQSFGSFTGILHKK 778
F+ S+S N K S TS +NK + ++T H +
Sbjct: 763 SFTSNSSSKNNSHFDKTDS-----TSDANKPREEENYTSATHNR 801
>YFR022w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 733
Score = 323 bits (828), Expect = 6e-88
Identities = 223/639 (34%), Positives = 320/639 (49%), Gaps = 39/639 (6%)
Query: 2 KKTSRSLSLFDIRLEGTDHDVIVVKGTVDEAPXXXXXXXXXXXXREPIYAKKISLTLYGV 61
K T + LFDIRL+ D+DVI++KG +EAP EP+ K ISL LYG
Sbjct: 7 KSTKKKPLLFDIRLKNVDNDVILLKGPPNEAPSVLLSGCIVLSINEPMQIKSISLRLYGK 66
Query: 62 IKLNVTTMVQGPRGPA--------PRNVKYDRRFYELSLDDIDLHPHLVDGSTVKKPL-- 111
I+++V ++ P+ + P+ KY++ FY + D+++L +L G + L
Sbjct: 67 IQIDVP--LERPQDASSSSLSSSPPKIRKYNKVFYNYAWDNVNLKEYL-SGLRGQSGLAG 123
Query: 112 SRTNXXXXXXXXXXXXXXXXKNFASSASHAS-VLPEGNYVFPFSTILPGSLTESVEGLPN 170
S ++ K+ S+S +S L +GNY FPFS ILPGSL ESVE LPN
Sbjct: 124 SSSSSNILGTRQRAQSTSSLKSLKGSSSPSSCTLDKGNYDFPFSAILPGSLPESVESLPN 183
Query: 171 ATVFYKLQATLERGKFASDISTKKHVRVVRTLTPDALELFETVAVDNTWPQKVDYSISVP 230
V Y +++ +ER K SD+ +K++RV+RT++P A+EL ETV VDN+WP KVDYSISVP
Sbjct: 184 CFVTYSMESVIERSKNYSDLICRKNIRVLRTISPAAVELSETVCVDNSWPDKVDYSISVP 243
Query: 231 SKAIAIGSSTPINIMXXXXXXXXXXXXXXXSLVEXXXXXXXXXXXXGADRTILKVKIQDP 290
+KA+AIGS+TPINI L E +R + ++ ++DP
Sbjct: 244 NKAVAIGSATPINISIVPLSKGLKLGSIKVVLFENYQYCDPFPPVISENRQVTELNLEDP 303
Query: 291 LHHINNGEYDATNT--------TEFDFQDKWEINTSVRIPPNLSKCVQDCLILTNIKVRH 342
L+ ++GE++ + FQDKWEI+T ++IP +LS CVQDC + +NIKVRH
Sbjct: 304 LNE-SSGEFNGNGCFVNNPFFQPDHSFQDKWEIDTILQIPNSLSNCVQDCDVRSNIKVRH 362
Query: 343 KLKFVIALVNPDGHISELRASLPVQLFISPFVTVAVRNAXXXXXXXXXXXXXXXXEAL-- 400
KLKF I L+NPDGH SELRASLP+QLFISPFV ++++ E
Sbjct: 363 KLKFFIILINPDGHKSELRASLPIQLFISPFVALSIKPLSSSNLYSLFSTTNQKDENSSQ 422
Query: 401 -EKDDLMFAHSNSEVNLNSVDIALNNDASAGPNTSLFAPPNYGNHVYDRLWNNIMVEDTP 459
E+++ +F+ S S L + + + S + L PPNY HVYDRL++
Sbjct: 423 EEEEEYLFSRSASVTGLELL-ADMRSGGSVPTISDLMTPPNYEMHVYDRLYSGSFTRTAV 481
Query: 460 VNSGTQSPAEFNQPPTLSHSSDVXXXXXXXXXXXXXXXMEEPDGSGLNLDTQVPSRSALA 519
SGT +P S S V L L S +A
Sbjct: 482 ETSGTCTPLG-------SECSTVEDQQQDLEDLRIRLTKIRNQRDNLGLPPSASSAAASR 534
Query: 520 TPLSLQDVPSQLRVNDYFTLNSS-NRNNHSVLNVPSHLRSPSQMDSPGFDYLSRANSFEF 578
+ L +VP+ + S+ N+ SV V S++ SP ++ E
Sbjct: 535 SLSPLLNVPAPEDGTERILPQSALGPNSGSVPGVHSNVSPVLLSRSPA----PSVSAHEV 590
Query: 579 KAGSPSRNDWEISSLSRVPSYDNAMKTASTMGELPPAYP 617
N E +L++VPSY AMK +LPP+YP
Sbjct: 591 LPVPSGLNYPETQNLNKVPSYGKAMKYDIIGEDLPPSYP 629
>SPAC31A2.12 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 596
Score = 184 bits (468), Expect = 3e-46
Identities = 163/576 (28%), Positives = 242/576 (41%), Gaps = 111/576 (19%)
Query: 9 SLFDIRLEGTDHDVIVVKGTVDEAPXXXXXXXXXXXXREPIYAKKISLTLYGVIKLNVTT 68
S FDIR+ +HD+IV++G D A E I K ISL L G +++ +
Sbjct: 12 SYFDIRV-AAEHDLIVIQGLADSAEPTPLSGSVVLCLNEAISVKAISLKLVGKCRISWSE 70
Query: 69 MVQGPRGPAPRNVKYDRRFYELSLDDIDLHPHLVDGSTVKKPLSRTNXXXXXXXXXXXXX 128
RG R+ K + YE + + P + N
Sbjct: 71 PSPTVRG-GQRHNKQEYVVYEKNW--------------IFVPYTGANRT----------- 104
Query: 129 XXXKNFASSASHASVLPEGNYVFPFSTILPGSLTESVEGLPNATVFYKLQATLERGKFAS 188
L GNY +PF +LPG + ESVEGL + V Y+L+A+++R AS
Sbjct: 105 ---------------LRAGNYEYPFHVMLPGDIAESVEGLQSCYVVYRLKASIDRTGLAS 149
Query: 189 DISTKKHVRVVRTLTPDALELFETVAVDNTWPQKVDYSISVPSKAIAIGSSTPINIMXXX 248
+ KKH+R++R L DA+E +T++VDNTWP K++Y+ISVP+KA AIGS PI+ +
Sbjct: 150 KMVKKKHIRLIRALPADAIEYTQTISVDNTWPNKIEYTISVPTKAYAIGSYIPIHFVLVP 209
Query: 249 XXXXXXXXXXXXSLVEXXXXXXXXXXXXGADRTILKVKIQDPLHHINNGEYDATNTTEFD 308
+L E G + +V+ L T E +
Sbjct: 210 LLKRLTIGKISITLKE-YITLHVAHGYNGLPASKDEVRTVRSLQ---------TEELE-E 258
Query: 309 FQDKWEINTSVRIPPNLSKCVQDCLILTNIKVRHKLKFVIALVNPDGHISELRASLPVQL 368
F D +E+ ++ +P +L +C+QDC L IK+RHKLKF ++L NPDGHISELRA+LPV L
Sbjct: 259 FSDHYELTKNLELPSSLVECLQDC-DLDGIKIRHKLKFSVSLRNPDGHISELRAALPVVL 317
Query: 369 FISPFVTVAVRNAXXXXXXXXXXXXXXXXEALEKDDLMFAHSNSEVNLNSVDIALNNDAS 428
I P + E + L N S + L
Sbjct: 318 MIPP---------------------QLFGDRAEVESL-------RENFESFNQPL----- 344
Query: 429 AGPNTSLFAPPNYGNHVYDRLWNNIMVE--DTPVNSGTQSP-AEFNQPPTLSHSSDVXXX 485
P+Y N +YDRL++ + DTP+ SG +P + PT ++S+
Sbjct: 345 ----------PSYQNSMYDRLYDGLSYSNLDTPLPSGATTPRRRDSMEPT--YASNEAHR 392
Query: 486 XXXXXXXXXXXXMEEPDGSGLNLDTQVPSRSALATPLSLQDVPSQLRVNDYFTLNSSNRN 545
++P G N + SL PS + T N S +
Sbjct: 393 RQLIAGLTELALQQQPQGRSPNEHSPSNHPEDFPPSFSLGSNPSSGAASAVITRNPSETS 452
Query: 546 NHSVLNVPSH---------LRSPSQMDSPGFDYLSR 572
+ VPS+ L SP Q P ++ ++R
Sbjct: 453 LADLSRVPSYKEATRSAVPLESPLQSTLPSYEDVAR 488
>SPCC584.15c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 594
Score = 149 bits (377), Expect = 1e-35
Identities = 103/336 (30%), Positives = 150/336 (43%), Gaps = 54/336 (16%)
Query: 133 NFASSASHASVLPEGNYVFPFSTILPGSLTESVEGLPNATVFYKLQATLERG-KFASDIS 191
+F + A V+ +GNY +PF LP + +S+EG+P + Y L A+LER + +++
Sbjct: 96 SFLAPNESAKVIDQGNYEYPFYYELPPDIPDSIEGIPGCHIIYTLTASLERATQPPTNLE 155
Query: 192 TKKHVRVVRTLTPDALELFETVAVDNTWPQKVDYSISVPSKAIAIGSSTPINIMXXXXXX 251
T RV+RT+ P++L+L +V+V + WP KV+Y S+PSK AIGS P+NI
Sbjct: 156 TALQFRVIRTIPPNSLDLMHSVSVSDIWPLKVNYETSIPSKVYAIGSEIPVNITLYPLLK 215
Query: 252 XXXXXXXXXSLVEXXXXXXXXXXXXGADRTILKVKIQDPLHHINNGEYDATNTTEFDFQD 311
L E R K + T D
Sbjct: 216 GLDVGKVTLVLKEYCTLFITSKAYSSTCRKEFKRAL-----------VKKTIPGLPMVDD 264
Query: 312 KWEINTSVRIPPNLSKCVQDCLILTNIKVRHKLKFVIALVNPDGHISELRASLPVQLFIS 371
W+ V+IP +L +C QDC L I+V HKL+ I+L+NPDGH+SELR SLP+ L IS
Sbjct: 265 YWQDQIMVKIPDSLGECTQDC-DLNCIRVHHKLRLSISLLNPDGHVSELRNSLPLSLVIS 323
Query: 372 PFVTVAVRNAXXXXXXXXXXXXXXXXEALEKDDLMFAHSNSEVNLNSVDIALNNDASAGP 431
P + A + + NS VN N +
Sbjct: 324 PVM----------------------FGARPTEGVFTGDHNSYVNENIL------------ 349
Query: 432 NTSLFAPPNYGNHVYDRLWNNIMVEDTPVNSGTQSP 467
P+Y HV+D LW+ I E+ + SG +P
Sbjct: 350 -------PSYDKHVFDVLWDGIPSENPQLQSGFTTP 378
>YGR068c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 586
Score = 108 bits (271), Expect = 2e-23
Identities = 76/278 (27%), Positives = 129/278 (46%), Gaps = 50/278 (17%)
Query: 136 SSASHASVLPEGNYVFPFSTILPGSLTESVEGLPNATVFYKLQATLE-RGKFASDISTK- 193
S +S+ ++ GNY PF+T+LP + E++EGL + ++ Y +A ++ R + +D+S
Sbjct: 220 SGSSYLFLMKRGNYELPFNTMLPPEVCETIEGLQSGSILYSFEAIIDGRQLWDTDLSVHT 279
Query: 194 ---------------------------KHVRVVRTLTPDALELFETVAVDNTWPQKVDYS 226
K++R++RTL+ D L + E ++V NTW K+ Y
Sbjct: 280 SPHGPIGSTSTSGNGMRTKNKIIIKKFKYLRILRTLSMDNLAMQEEISVGNTWRDKLQYE 339
Query: 227 ISVPSKAIAIGSSTPINIMXXXXXXXXXXXXXXXSLVEXXXXXXXXXXXXGADRTILKVK 286
S+PS+A+ IGS+TP+ I +L++ + ++K+
Sbjct: 340 TSIPSRAVPIGSTTPVKIKIFPFEKNIRLDRIEMALIQYYAMKDSSAQIYDDEIAVMKI- 398
Query: 287 IQDPLHHINNGEYDATNTTEF-DFQDKWEINTSVRIPPNLSKCVQDCLILTN-IKVRHKL 344
T+ +F DK +++ IP NL + QDC + N I+V HKL
Sbjct: 399 ---------------THLADFGPLTDKLDVDCPFTIPDNLKQITQDCCLQDNLIRVMHKL 443
Query: 345 KFVIALVNP-DGHIS--ELRASLPVQLFISPFVTVAVR 379
+ I L DG E++A LP+ LFISP + + R
Sbjct: 444 QVRILLQRQVDGEYKNLEIKAQLPMLLFISPHLPMKGR 481
>SPBC2D10.04 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 658
Score = 62.4 bits (150), Expect = 3e-09
Identities = 46/168 (27%), Positives = 74/168 (43%), Gaps = 28/168 (16%)
Query: 81 VKYDRRFYELSLDDIDLHPHLVD-----GSTVKKPLSRTNXXXXXXXXXXXXXXXXKNFA 135
+ ++ +FYE ++ D D H D G + P S A
Sbjct: 223 ISHNWKFYEPTMKDADAPQHGADVARLVGEQLPLPSSA---------------------A 261
Query: 136 SSASHASVLPEGNYVFPFSTILPGSLTESVEGLPNATVFYKLQATLER-GKFASDISTKK 194
+S SV G Y + F +P ESVE V Y L+AT+ER G F S+++ +
Sbjct: 262 ASLRGYSVFAPGEYTYNFDLAIPNCFPESVEA-KMGWVRYFLEATVERFGTFKSNLNGRT 320
Query: 195 HVRVVRTLTPDALELFETVAVDNTWPQKVDYSISVPSKAIAIGSSTPI 242
V++VRT +P +L E + + W +++ Y + V K+ +G PI
Sbjct: 321 PVQLVRTPSPASLSSSELINISRDWDERLHYELQVSGKSFRLGEVVPI 368
>YJL084c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 1046
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/112 (32%), Positives = 60/112 (53%), Gaps = 3/112 (2%)
Query: 133 NFAS-SASHASVLPEGNYVFPFSTILPGSLTESVEGLPNATVFYKLQATLER-GKFASDI 190
NF S S V G+Y++ F ++P + ES++ V Y L A++ER G F S+I
Sbjct: 273 NFTSGSGGEFFVFQPGDYIYAFEELIPQAYPESIKA-DFGFVEYFLFASIERPGAFKSNI 331
Query: 191 STKKHVRVVRTLTPDALELFETVAVDNTWPQKVDYSISVPSKAIAIGSSTPI 242
S ++ V +VRT +++E E + + W ++ Y I + SK I + + PI
Sbjct: 332 SARQVVNIVRTQAHNSVEESEPIIISRDWENQLYYDIVIASKDIILDAFLPI 383
>YKR021w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 915
Score = 50.8 bits (120), Expect = 8e-06
Identities = 30/98 (30%), Positives = 52/98 (52%), Gaps = 2/98 (2%)
Query: 147 GNYVFPFSTILPGSLTESVEGLPNATVFYKLQATLER-GKFASDISTKKHVRVVRTLTPD 205
G+Y++ F + S ES++ +V YKL +ER G F S I T+ ++VVR +
Sbjct: 275 GDYIYTFEQPISQSYPESIKA-NFGSVEYKLSIDIERFGAFKSTIHTQLPIKVVRLPSDG 333
Query: 206 ALELFETVAVDNTWPQKVDYSISVPSKAIAIGSSTPIN 243
++E E +A+ W + Y + + SK I + + PI+
Sbjct: 334 SVEETEAIAISKDWKDLLHYDVVIFSKEIVLNAFLPID 371
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.313 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,373,298
Number of Sequences: 60738
Number of extensions: 1688914
Number of successful extensions: 3311
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 3275
Number of HSP's gapped (non-prelim): 19
length of query: 784
length of database: 30,389,216
effective HSP length: 114
effective length of query: 670
effective length of database: 23,465,084
effective search space: 15721606280
effective search space used: 15721606280
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)