ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIV1267 check: MH E KOG0786 Amino acid transport and metabolism 3-isopropylmalate dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIV1267 420903 421988 362
(362 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YCL018w [E] KOG0786 3-isopropylmalate dehydrogenase 576 e-164
At1g80560 [E] KOG0786 3-isopropylmalate dehydrogenase 255 6e-68
At1g31180 [E] KOG0786 3-isopropylmalate dehydrogenase 253 3e-67
At5g14200 [E] KOG0786 3-isopropylmalate dehydrogenase 245 8e-65
SPBC1A4.02c [E] KOG0786 3-isopropylmalate dehydrogenase 196 3e-50
YIL094c [E] KOG0785 Isocitrate dehydrogenase alpha subunit 128 1e-29
SPAC31G5.04 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 114 3e-25
At5g03290 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 111 1e-24
At3g09805 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 103 4e-22
SPBC902.05c [E] KOG0785 Isocitrate dehydrogenase alpha subunit 96 6e-20
7293593 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 92 9e-19
YOR136w [E] KOG0785 Isocitrate dehydrogenase alpha subunit 90 6e-18
At4g35260 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 89 8e-18
Hs5031777 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 86 1e-16
CE10354 [E] KOG0785 Isocitrate dehydrogenase alpha subunit 86 1e-16
YNL037c [E] KOG0784 Isocitrate dehydrogenase gamma subunit 84 2e-16
At4g35650 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 82 1e-15
At2g17130 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 80 5e-15
Hs5901982 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 76 7e-14
CE08620 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 76 9e-14
CE00970 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 74 4e-13
SPAC11G7.03 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 72 1e-12
7301367 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 70 4e-12
7300799 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 69 8e-12
CE16887 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 68 2e-11
Hs4758582 [E] KOG0784 Isocitrate dehydrogenase gamma subunit 62 1e-09
>YCL018w [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 364
Score = 576 bits (1485), Expect = e-164
Identities = 287/360 (79%), Positives = 317/360 (87%)
Query: 3 KNIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALE 62
K IVVLPGDHVG+E+T EAIKVL AI++VR +KF+F++HLIGGAAIDATG PLPDEALE
Sbjct: 5 KKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALE 64
Query: 63 ASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKP 122
ASKKADAVLLGAVGGPKWGTG+VRPEQGLLKIRKEL LYANLRPCNFA P+KP
Sbjct: 65 ASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKP 124
Query: 123 EYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQNPP 182
++AKGTDFVVVRELVGGIYFG+RKED+GDGVAWDSE+Y+VPEVQRITRMAAF+ALQ PP
Sbjct: 125 QFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQHEPP 184
Query: 183 LPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVVIT 242
LPIWSLDKANVLASSRLWRKTVEETIK EFP L VQHQLIDSAAMILVK+PT LNG++IT
Sbjct: 185 LPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNGIIIT 244
Query: 243 NNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPANKVNPIAT 302
+NMFGDIISDEASVI D N AFGLYEPCHGSAPDLP NKVNPIAT
Sbjct: 245 SNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLPKNKVNPIAT 304
Query: 303 ILSAAMMLKLSLDLVEEGRALEEAVRNVLDAGVRTGDLGGSNSTTEVGDAIAKAVKEILA 362
ILSAAMMLKLSL+L EEG+A+E+AV+ VLDAG+RTGDLGGSNSTTEVGDA+A+ VK+ILA
Sbjct: 305 ILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEVKKILA 364
>At1g80560 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 405
Score = 255 bits (652), Expect = 6e-68
Identities = 154/364 (42%), Positives = 221/364 (60%), Gaps = 22/364 (6%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEAS 64
I +LPGD +G EV A VL + ++FNF+ IGGAA+D G PLP+E + A+
Sbjct: 45 ITLLPGDGIGPEVVSIAKNVLQQAGSLEG-VEFNFREMPIGGAALDLVGVPLPEETISAA 103
Query: 65 KKADAVLLGAVGGPKWGTGA--VRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKP 122
K++DAVLLGA+GG KW +RPE+GLL+IR L ++ANLRP LK
Sbjct: 104 KESDAVLLGAIGGYKWDNNEKHLRPEKGLLQIRAALKVFANLRPAT-VLPQLVDASTLKR 162
Query: 123 EYAKGTDFVVVRELVGGIYFGE----RKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQ 178
E A+G D +VVREL GGIYFGE + + G+ V +++E Y+ E+ RI R+A A +
Sbjct: 163 EVAEGVDLMVVRELTGGIYFGEPRGIKTNENGEEVGFNTEVYAAHEIDRIARVAFETARK 222
Query: 179 QNPPLPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNG 238
+ L S+DKANVL +S LWRK V + +E+P + + H +D+AAM LV+ P + +
Sbjct: 223 RRGKL--CSVDKANVLEASILWRKRV-TALASEYPDVELSHMYVDNAAMQLVRDPKQFD- 278
Query: 239 VVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA-NKV 297
++TNN+FGDI+SDEAS+I ++ GL+EP HGSAPD+ +K
Sbjct: 279 TIVTNNIFGDILSDEASMITGSIGMLPSASL-----SDSGPGLFEPIHGSAPDIAGQDKA 333
Query: 298 NPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAGVRTGDLGGSNS----TTEVGDAI 353
NP+ATILSAAM+LK L + + +E+AV L+ G RTGD+ + + E+G+ +
Sbjct: 334 NPLATILSAAMLLKYGLGEEKAAKRIEDAVLVALNNGFRTGDIYSAGTKLVGCKEMGEEV 393
Query: 354 AKAV 357
K+V
Sbjct: 394 LKSV 397
>At1g31180 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 404
Score = 253 bits (646), Expect = 3e-67
Identities = 152/365 (41%), Positives = 219/365 (59%), Gaps = 22/365 (6%)
Query: 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEA 63
NI +LPGD +G EV A VL ++ ++F+FQ GGAA+D G PLP+E A
Sbjct: 45 NITLLPGDGIGPEVISVAKNVLQKAGFLQG-LEFDFQEMPFGGAALDLVGVPLPEETSTA 103
Query: 64 SKKADAVLLGAVGGPKWGTGA--VRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLK 121
+K++DA+LLGA+GG KW +RPE GLL IR++L ++ANLRP LK
Sbjct: 104 AKQSDAILLGAIGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPAT-VLPQLVDASTLK 162
Query: 122 PEYAKGTDFVVVRELVGGIYFGERK----EDEGDGVAWDSEKYSVPEVQRITRMAAFLAL 177
E A+G D ++VREL GGIYFGE + + G+ V +++E Y+ E+ RI R+A A
Sbjct: 163 KEVAQGVDMMIVRELTGGIYFGEPRGITINENGEEVGFNTEIYAAHEIDRIARVAFETAR 222
Query: 178 QQNPPLPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
++ L S+DKANVL +S LWRK V + +E+P + + H +D+AAM LV+ P + +
Sbjct: 223 KRRGKL--CSVDKANVLDASILWRKRV-TALASEYPDVELSHMYVDNAAMQLVRDPKQFD 279
Query: 238 GVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA-NK 296
++TNN+FGDI+SDEAS+I GL+EP HGSAPD+ +K
Sbjct: 280 -TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGP-----GLFEPIHGSAPDIAGQDK 333
Query: 297 VNPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAGVRTGDLGGSNS----TTEVGDA 352
NP+ATILSAAM+LK L + + +E+AV + L+ G RTGD+ + E+G+
Sbjct: 334 ANPLATILSAAMLLKYGLGEEKAAKMIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEE 393
Query: 353 IAKAV 357
+ K+V
Sbjct: 394 VLKSV 398
>At5g14200 [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 409
Score = 245 bits (625), Expect = 8e-65
Identities = 147/366 (40%), Positives = 215/366 (58%), Gaps = 22/366 (6%)
Query: 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEA 63
NI +LPGD +G EV A VL + ++F+F+ +GGAA+D G PLP+E A
Sbjct: 48 NIALLPGDGIGPEVISVAKNVLQKAGSLEG-LEFDFKEMPVGGAALDLVGVPLPEETFTA 106
Query: 64 SKKADAVLLGAVGGPKWGTGA--VRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLK 121
+K +DA+LLGA+GG KW +RPE L +R++L ++ANLRP LK
Sbjct: 107 AKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPAT-VLPQLVDASTLK 165
Query: 122 PEYAKGTDFVVVRELVGGIYFGERK----EDEGDGVAWDSEKYSVPEVQRITRMAAFLAL 177
E A+G D ++VREL GGIYFGE + + G+ V +E Y+ E+ RI R+A A
Sbjct: 166 KEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETAR 225
Query: 178 QQNPPLPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
++ L S+DKANVL +S LWRK V + +E+P + + H +D+AAM L++ P + +
Sbjct: 226 KRRGKL--CSVDKANVLDASILWRKRV-TALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282
Query: 238 GVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA-NK 296
++TNN+FGDI+SDEAS+I GL+EP HGSAPD+ +K
Sbjct: 283 -TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGP-----GLFEPIHGSAPDIAGQDK 336
Query: 297 VNPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAGVRTGDLGGSNS----TTEVGDA 352
NP+ATILSAAM+LK L + + +E+AV + L+ G RTGD+ + E+G+
Sbjct: 337 ANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEE 396
Query: 353 IAKAVK 358
+ K+V+
Sbjct: 397 VLKSVE 402
>SPBC1A4.02c [E] KOG0786 3-isopropylmalate dehydrogenase
Length = 220
Score = 196 bits (499), Expect = 3e-50
Identities = 111/219 (50%), Positives = 143/219 (64%), Gaps = 9/219 (4%)
Query: 152 GVAWDSEKYSVPEVQRITRMAAFLALQQNPPLPIWSLDKANVLASSRLWRKTVEETIKTE 211
G A D+ YS+ EV RI R+AA+LA NPP P+ LDKANVLA+SRLWRKTV + K E
Sbjct: 2 GYAMDTWPYSLEEVSRIARLAAWLAETSNPPAPVTLLDKANVLATSRLWRKTVAKIFKEE 61
Query: 212 FPQLTVQHQLIDSAAMILVKSPTKLNGVVITNNMFGDIISDEASVI--XXXXXXXXXXXX 269
+P LT+++QLIDSAAM+LVKSP LNGVV+T+N+FGDIISDEASVI
Sbjct: 62 YPHLTLKNQLIDSAAMLLVKSPRTLNGVVLTDNLFGDIISDEASVIPGSLGLLPSASLSG 121
Query: 270 XXXXDTNKAFGLYEPCHGSAPDLPANK-VNPIATILSAAMMLKLSLDLVEEGRALEEAVR 328
K L EP HGSAPD+ VNP+ TILSA+++L+ L+ +E A+E AVR
Sbjct: 122 VVGKSEEKVHCLVEPIHGSAPDIAGKGIVNPVGTILSASLLLRYGLNAPKEAEAIEAAVR 181
Query: 329 NVLD------AGVRTGDLGGSNSTTEVGDAIAKAVKEIL 361
VLD G+ T DLGG ST ++ A+ + +++IL
Sbjct: 182 KVLDDTSIGGRGLYTRDLGGEASTADITKAVVEELEKIL 220
>YIL094c [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 371
Score = 128 bits (321), Expect = 1e-29
Identities = 113/366 (30%), Positives = 175/366 (46%), Gaps = 35/366 (9%)
Query: 2 SKNIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEAL 61
S I ++PGD +GKEV +VL + + + FNF G TG LPDE +
Sbjct: 23 SLTIGLIPGDGIGKEVIPAGKQVLENLNS-KHGLSFNFIDLYAGFQTFQETGKALPDETV 81
Query: 62 EASKK-ADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPL 120
+ K+ L GAV P T ++ +R+E+GL+AN+RP +
Sbjct: 82 KVLKEQCQGALFGAVQSPT--TKVEGYSSPIVALRREMGLFANVRPVK----------SV 129
Query: 121 KPEYAKGTDFVVVRELVGGIYFGERK----EDEGDGVAWDSEKYSVPEVQRITRMAAFLA 176
+ E K D V+VRE +Y K + G VA +++ S +RI +A +A
Sbjct: 130 EGEKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIA 189
Query: 177 L---QQNPPLPIWSLDKANVLASSR-LWR---KTVEETIKTEFPQLTVQHQLIDSAAMIL 229
L Q + K+NVL+ S L+R K V E+ K ++ Q+ Q++DS L
Sbjct: 190 LKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRL 249
Query: 230 VKSPTKLNGVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSA 289
+ P + V++ N++GDI+SD A+ + + + EPCHGSA
Sbjct: 250 FREPQCFD-VIVAPNLYGDILSDGAAALVGSLGVVPSA------NVGPEIVIGEPCHGSA 302
Query: 290 PDLPANKV-NPIATILSAAMMLKLSLDLVEEGRALEEAV-RNVLDAGVRTGDLGGSNSTT 347
PD+ + NPIATI S A+ML+ L E + + +AV N+ + ++T DLGG ST
Sbjct: 303 PDIAGKGIANPIATIRSTALMLEF-LGHNEAAQDIYKAVDANLREGSIKTPDLGGKASTQ 361
Query: 348 EVGDAI 353
+V D +
Sbjct: 362 QVVDDV 367
>SPAC31G5.04 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 362
Score = 114 bits (284), Expect = 3e-25
Identities = 103/369 (27%), Positives = 171/369 (45%), Gaps = 45/369 (12%)
Query: 7 VLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASK- 65
++P D +GKEV A +++ + + ++KF+F G + TG LP+ +E K
Sbjct: 11 LIPADGIGKEVVPAARRLMENLP-AKHKLKFDFIDLDAGWGTFERTGKALPERTVERLKT 69
Query: 66 KADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKPEYA 125
+ +A L GAV P ++ +RK++GLYAN+RP L
Sbjct: 70 ECNAALFGAVQSPTHKVAGY--SSPIVALRKKMGLYANVRPVK----------SLDGAKG 117
Query: 126 KGTDFVVVRELVGGIYFGERK---EDEGDGVAWDSEKYSVPEVQRITRMAAFLA------ 176
K D V+VRE +Y E + G VA + S +I +MA +A
Sbjct: 118 KPVDLVIVRENTECLYVKEERMVQNTPGKRVAEAIRRISEEASTKIGKMAFEIAKSRQKI 177
Query: 177 -------LQQNPPLPIWSLDKANVLA-SSRLWRKTVE--ETIKTEFPQLTVQHQLIDSAA 226
+ + P + I + K+NV++ + L+R++ +++ + + V Q++DS
Sbjct: 178 RESGTYSIHKKPLVTI--IHKSNVMSVTDGLFRESCRHAQSLDPSYASINVDEQIVDSMV 235
Query: 227 MILVKSPTKLNGVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCH 286
L + P + VV+ N++GDI+SD A+ + + F + EP H
Sbjct: 236 YRLFREPECFD-VVVAPNLYGDILSDGAASL------IGSLGLVPSANVGDNFVMSEPVH 288
Query: 287 GSAPDLPANKV-NPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSN 344
GSAPD+ + NP+AT S A+ML+ + + + AV VL G V T DLGG +
Sbjct: 289 GSAPDIAGRGIANPVATFRSVALMLEF-MGHQDAAADIYTAVDKVLTEGKVLTPDLGGKS 347
Query: 345 STTEVGDAI 353
T E+ DA+
Sbjct: 348 GTNEITDAV 356
>At5g03290 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 372
Score = 111 bits (278), Expect = 1e-24
Identities = 106/353 (30%), Positives = 161/353 (45%), Gaps = 36/353 (10%)
Query: 7 VLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKK 66
+ PGD +G E+ + KV + ++ H +G T + L E+LE+ ++
Sbjct: 46 LFPGDGIGPEIAESVKKVFTTAG-----VPIEWEEHYVGTEIDPRTQSFLTWESLESVRR 100
Query: 67 ADAVLLGAVGGPKWGTGAVRPEQGL-LKIRKELGLYANLRPCNFAXXXXXXXXPLKPEYA 125
L G + P G G + L L +RKEL LYAN+RPC P
Sbjct: 101 NKVGLKGPMATPI-GKG----HRSLNLTLRKELNLYANVRPC--------YSLPGYKTRY 147
Query: 126 KGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMA--AFLALQQNPPL 183
D + +RE G Y G E V E + Q R+A AFL + +
Sbjct: 148 DDVDLITIRENTEGEYSGL----EHQVVRGVVESLKIITRQASLRVAEYAFLYAKTHGRE 203
Query: 184 PIWSLDKANVL-ASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVVIT 242
+ ++ KAN++ + L+ K E + ++P++T + +ID+ M+LVK+P L V++
Sbjct: 204 RVSAIHKANIMQKTDGLFLKCCRE-VAEKYPEITYEEVVIDNCCMMLVKNPA-LFDVLVM 261
Query: 243 NNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA-NKVNPIA 301
N++GDIISD + + L E HGSAPD+ N NP A
Sbjct: 262 PNLYGDIISDLCAGLVGGLGLTPSCNIG-----EDGVALAEAVHGSAPDIAGKNLANPTA 316
Query: 302 TILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
+LS MML+ L E+ + A+ N + G RT DLGGS++TTE AI
Sbjct: 317 LLLSGVMMLR-HLKFNEQAEQIHSAIINTIAEGKYRTADLGGSSTTTEFTKAI 368
>At3g09805 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 374
Score = 103 bits (257), Expect = 4e-22
Identities = 101/358 (28%), Positives = 162/358 (45%), Gaps = 46/358 (12%)
Query: 7 VLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKK 66
+ PGD +G E+ + +V A ++ ++ +G T + L + L++ K
Sbjct: 48 LFPGDGIGPEIAESVKQVFTAA-----DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLK 102
Query: 67 ADAVLLGAVGGPKWGTGAVRPEQGL-LKIRKELGLYANLRPCNFAXXXXXXXXPLKPEYA 125
L G + P G G + L L +RKEL LYAN+RPC P
Sbjct: 103 NKVGLKGPMATPI-GKG----HRSLNLTLRKELNLYANVRPC--------YSLPGYKTRY 149
Query: 126 KGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMA-------AFLALQ 178
D + +R E E E G+ K V ++ ITR A AFL +
Sbjct: 150 DDVDLITIR---------ENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAK 200
Query: 179 QNPPLPIWSLDKANVL-ASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
+ + ++ KAN++ + L+ + +E + ++P++ + +ID+ M+LVK+P L
Sbjct: 201 THGRKKVSAIHKANIMQKTDGLFLQCCDE-VAAKYPEIYYEKVVIDNCCMMLVKNPA-LF 258
Query: 238 GVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA-NK 296
V++ N++GDIISD + + L E HGSAPD+ N
Sbjct: 259 DVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIG-----EDGIALAEAVHGSAPDIAGMNL 313
Query: 297 VNPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
NP A +LS MML+ L L ++ + A+ N + G RT DLGGS++TT+ AI
Sbjct: 314 ANPTALLLSGVMMLR-HLKLNKQAEQIHSAIINTIAEGKYRTADLGGSSTTTDFTKAI 370
>SPBC902.05c [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 378
Score = 96.3 bits (238), Expect = 6e-20
Identities = 89/365 (24%), Positives = 162/365 (44%), Gaps = 45/365 (12%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEAS 64
+ ++ GD +G E+ ++ A ++ ++ + + T T +PD+A E+
Sbjct: 48 VTMIAGDGIGPEIAQSVERIFKAA-----KVPIEWERVKVYPILKNGT-TTIPDDAKESV 101
Query: 65 KKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKPEY 124
+K L G + P G G V L +R+ GL+AN+RPC
Sbjct: 102 RKNKVALKGPLATPI-GKGHVSMN---LTLRRTFGLFANVRPC----------------- 140
Query: 125 AKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMA-------AFLAL 177
T + + V + E E E G+ + V ++ ITR A AF
Sbjct: 141 VSITGYKTPYDNVNTVLIRENTEGEYSGIEHEVIPGVVQSIKLITRAASERVIRYAFQYA 200
Query: 178 QQNPPLPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
+Q I + KA ++ + + + E+P + ++ +++D+A + +V P N
Sbjct: 201 RQTGKNNITVVHKATIMRMADGLFLECAKELAPEYPDIELREEILDNACLKIVTDPVPYN 260
Query: 238 G-VVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPANK 296
V++ N++GDI+SD + + N+A ++E HG+APD+
Sbjct: 261 NTVMVMPNLYGDIVSDMCAGLIGGLGLTPSGNIG-----NQA-SIFEAVHGTAPDIAGKG 314
Query: 297 V-NPIATILSAAMMLKLSLDLVEEGRALEEAVRNVL--DAGVRTGDLGGSNSTTEVGDAI 353
+ NP A +LS+ MMLK ++L + + +E A+ + L + RT DLGG ++ + DAI
Sbjct: 315 LANPTALLLSSVMMLK-HMNLNDYAKRIESAIFDTLANNPDARTKDLGGKSNNVQYTDAI 373
Query: 354 AKAVK 358
+K
Sbjct: 374 ISKLK 378
>7293593 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 377
Score = 92.4 bits (228), Expect = 9e-19
Identities = 99/358 (27%), Positives = 156/358 (42%), Gaps = 37/358 (10%)
Query: 2 SKNIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEAL 61
+K + ++PGD +G E++ K+ A A V E + A+D T PD
Sbjct: 47 TKKVTLIPGDGIGPEISAAVQKIFTA-ANVPIEWE-----------AVDVTPVRGPDGKF 94
Query: 62 EASKKA-DAVLLGAVG--GPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXX 118
+ A D+V +G GP L +RKE LYAN+RPC
Sbjct: 95 GIPQAAIDSVNTNKIGLKGPLMTPVGKGHRSLNLALRKEFNLYANVRPCR-------SLE 147
Query: 119 PLKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQ 178
K Y D V +RE G Y G E DGV S K E + AF +
Sbjct: 148 GYKTLY-DDVDVVTIRENTEGEYSGIEHEIV-DGVV-QSIKLITEEASKRVAEYAFQYAK 204
Query: 179 QNPPLPIWSLDKANVL-ASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLN 237
N + + KAN++ S L+ + V + + +FP++ + + +D+ + +V++P K +
Sbjct: 205 NNNRKKVTVVHKANIMRMSDGLFLRCVRD-MAQKFPEIQFEEKYLDTVCLNMVQNPGKYD 263
Query: 238 GVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPANKV 297
V++ N++GDI+SD + + L+E HG+APD+ +
Sbjct: 264 -VLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG------ALFESVHGTAPDIAGKDL 316
Query: 298 -NPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
NP A +LSA MML+ ++L +E A + G TGDLGG +E + I
Sbjct: 317 ANPTALLLSAVMMLR-HMELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEI 373
>YOR136w [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 369
Score = 89.7 bits (221), Expect = 6e-18
Identities = 91/353 (25%), Positives = 159/353 (44%), Gaps = 32/353 (9%)
Query: 8 LPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKKA 67
+ GD +G E++ K+ +A + ++ + ++ T +PD A+++ K
Sbjct: 42 IEGDGIGPEISKSVKKIFSAA-----NVPIEWESCDVSPIFVNGL-TTIPDPAVQSITKN 95
Query: 68 DAVLLGAVGGPKWGTGAVRPEQGL-LKIRKELGLYANLRPCNFAXXXXXXXXPLKPEYAK 126
L G + P G G + L L +RK GL+AN+RP K Y +
Sbjct: 96 LVALKGPLATPI-GKG----HRSLNLTLRKTFGLFANVRPAK-------SIEGFKTTY-E 142
Query: 127 GTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQNPPLPIW 186
D V++RE G Y G + GV + + +R+ R A A P I
Sbjct: 143 NVDLVLIRENTEGEYSGI-EHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVI- 200
Query: 187 SLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVV-ITNNM 245
+ K+ + + V + + E+P LT++ +LID++ + +V +P+ V + N+
Sbjct: 201 VVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNL 260
Query: 246 FGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA-NKVNPIATIL 304
+GDI+SD S + + ++E HGSAPD+ +K NP A +L
Sbjct: 261 YGDILSDLNSGLSAGSLGLTPSA-----NIGHKISIFEAVHGSAPDIAGQDKANPTALLL 315
Query: 305 SAAMMLKLSLDLVEEGRALEEAVRNVLDAGV--RTGDLGGSNSTTEVGDAIAK 355
S+ MML + L ++ AV + + +G RTGDL G+ +T+ +A+ K
Sbjct: 316 SSVMMLN-HMGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIK 367
>At4g35260 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 367
Score = 89.4 bits (220), Expect = 8e-18
Identities = 95/351 (27%), Positives = 161/351 (45%), Gaps = 30/351 (8%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEAS 64
+ ++PGD +G VT+ +V+ A+ F+ + + G + +P E +E+
Sbjct: 40 VTLIPGDGIGPLVTNAVEQVMEAM-----HAPIFFEKYDVHGEM-----SRVPPEVMESI 89
Query: 65 KKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKPEY 124
+K L G + P G + Q +RKEL L+A+L C P P
Sbjct: 90 RKNKVCLKGGLKTPVGGGVSSLNVQ----LRKELDLFASLVNC--------FNLPGLPTR 137
Query: 125 AKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQNPPLP 184
+ D VV+RE G Y G E GV + + +RI + A A N
Sbjct: 138 HENVDIVVIRENTEGEYAGLEHEVV-PGVVESLKVITKFCSERIAKYAFEYAYLNNRK-K 195
Query: 185 IWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVVITN 243
+ ++ KAN++ + L+ ++ E K ++P +T ++D+ M LV P + + V++T
Sbjct: 196 VTAVHKANIMKLADGLFLESCREVAK-KYPSITYNEIIVDNCCMQLVAKPEQFD-VMVTP 253
Query: 244 NMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPANKVNPIATI 303
N++G+++++ A+ I + G G + NK NP+A +
Sbjct: 254 NLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQ-GASAGNVGKDKIVLENKANPVALL 312
Query: 304 LSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
LS+AMML+ L LE AV+ V+ G RT DLGG+++T EV DA+
Sbjct: 313 LSSAMMLR-HLQFPSFADRLETAVKKVIAEGKCRTKDLGGTSTTQEVVDAV 362
>Hs5031777 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 366
Score = 85.5 bits (210), Expect = 1e-16
Identities = 92/363 (25%), Positives = 156/363 (42%), Gaps = 34/363 (9%)
Query: 3 KNIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTP--LPDEA 60
+ + ++PGD +G E++ +K+ +A K Q AI G +P EA
Sbjct: 32 QTVTLIPGDGIGPEISAAVMKIFDAA-------KAPIQWEERNVTAIQGPGGKWMIPSEA 84
Query: 61 LEASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPL 120
E+ K L G + P A P LL +RK LYAN+RPC
Sbjct: 85 KESMDKNKMGLKGPLKTP---IAAGHPSMNLL-LRKTFDLYANVRPC-------VSIEGY 133
Query: 121 KPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQN 180
K Y + V +RE G Y G DGV + + +RI A F + N
Sbjct: 134 KTPYTD-VNIVTIRENTEGEYSGIEHVIV-DGVVQSIKLITEGASKRIAEFA-FEYARNN 190
Query: 181 PPLPIWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGV 239
+ ++ KAN++ S L+ + E ++ + +D+ + +V+ P++ + V
Sbjct: 191 HRSNVTAVHKANIMRMSDGLFLQKCREVAES-CKDIKFNEMYLDTVCLNMVQDPSQFD-V 248
Query: 240 VITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA-NKVN 298
++ N++GDI+SD + + ++E HG+APD+ + N
Sbjct: 249 LVMPNLYGDILSDLCAGLIGGLGVTPSGNIGA-----NGVAIFESVHGTAPDIAGKDMAN 303
Query: 299 PIATILSAAMMLKLSLDLVEEGRALEEA-VRNVLDAGVRTGDLGGSNSTTEVGDAIAKAV 357
P A +LSA MML+ + L + +E A + D T DLGG+ ++ + I + V
Sbjct: 304 PTALLLSAVMMLR-HMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRV 362
Query: 358 KEI 360
K++
Sbjct: 363 KDL 365
>CE10354 [E] KOG0785 Isocitrate dehydrogenase alpha subunit
Length = 374
Score = 85.5 bits (210), Expect = 1e-16
Identities = 91/378 (24%), Positives = 152/378 (40%), Gaps = 49/378 (12%)
Query: 3 KNIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTP------- 55
+ + ++PGD +G E++ K+ A I +D T
Sbjct: 25 RRVTLIPGDGIGPEISASVQKIFEAADAP------------IAWDPVDVTPVKGRDGVFR 72
Query: 56 LPDEALEASKKADAVLLGAVGGPKWGTGAVRPEQGL-LKIRKELGLYANLRPCNFAXXXX 114
+P +E L G + P G G + L L +RKE LYAN+RPC
Sbjct: 73 IPSRCIELMHANKVGLKGPLETPI-GKG----HRSLNLAVRKEFSLYANVRPCRSLEGHK 127
Query: 115 XXXXPLKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAF 174
D V +RE G Y G E V S K R AF
Sbjct: 128 TLYD--------NVDVVTIRENTEGEYSGIEHEIVPGVV--QSIKLITETASRNVASFAF 177
Query: 175 LALQQNPPLPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPT 234
+QN + ++ KAN++ S ++ +P + + +D+ + +V+ P+
Sbjct: 178 EYARQNGRKVVTAVHKANIMRQSDGLFLSICREQAALYPDIKFKEAYLDTVCLNMVQDPS 237
Query: 235 KLNGVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXX----------DTNKAFGLYEP 284
+ + V++ N++GDI+SD + + T LY
Sbjct: 238 QYD-VLVMPNLYGDILSDLCAGLVGGLGVTPSGNIGKGAAVFDEIQFFIQTKLTKFLYRS 296
Query: 285 CHGSAPDLPA-NKVNPIATILSAAMMLKLSLDLVEEGRALEEAVRN-VLDAGVRTGDLGG 342
HG+APD+ +K NP A +LSA MML+ ++L + +E+AV + + D +TGDLGG
Sbjct: 297 VHGTAPDIAGQDKANPTALLLSAVMMLRY-MNLPQHAARIEKAVFDAIADGRAKTGDLGG 355
Query: 343 SNSTTEVGDAIAKAVKEI 360
+ + + + VK++
Sbjct: 356 TGTCSSFTADVCARVKDL 373
>YNL037c [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 360
Score = 84.3 bits (207), Expect = 2e-16
Identities = 92/357 (25%), Positives = 155/357 (42%), Gaps = 42/357 (11%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEAS 64
+ ++PGD VGKE+TD + F ++ I I+ T + EA
Sbjct: 31 VTLIPGDGVGKEITDSVRTI------------FEAENIPIDWETINIKQTDHKEGVYEAV 78
Query: 65 KKADAVLLGAVGGPKWGTGAVRPEQGLLKI--RKELGLYANLRPCNFAXXXXXXXXPLKP 122
+ +G G W T A + G L + RK+L +YAN+ LK
Sbjct: 79 ESLKRNKIGLKG--LWHTPADQTGHGSLNVALRKQLDIYANV----------ALFKSLKG 126
Query: 123 EYAK--GTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQN 180
+ D +V+RE G + G E GV + + P+ +RI R A A + N
Sbjct: 127 VKTRIPDIDLIVIRENTEGEFSGLEHESV-PGVVESLKVMTRPKTERIARFAFDFAKKYN 185
Query: 181 PPLPIWSLDKANVL-ASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGV 239
+ ++ KAN++ L+R + E + E+P + V ++D+A+M V P + + V
Sbjct: 186 RK-SVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD-V 243
Query: 240 VITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEP--CHGSAPDLPANKV 297
++T +M+G I+ + + + + + + ++EP H N
Sbjct: 244 LVTPSMYGTILGNIGAAL------IGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVA 297
Query: 298 NPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAGVR-TGDLGGSNSTTEVGDAI 353
NP A ILS+ +ML L L E + +AV + G T D+GGS+STT+ + I
Sbjct: 298 NPTAMILSSTLMLN-HLGLNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEI 353
>At4g35650 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 368
Score = 82.0 bits (201), Expect = 1e-15
Identities = 94/358 (26%), Positives = 160/358 (44%), Gaps = 30/358 (8%)
Query: 3 KNIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALE 62
+ + ++PGD +G VT +V+ A+ +F+ + + G +P+E +E
Sbjct: 39 RTVTLIPGDGIGPLVTGAVEQVMEAM-----HAPVHFERYEVLGNM-----RKVPEEVIE 88
Query: 63 ASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKP 122
+ K+ L G + P G + Q +RKEL ++A+L C P
Sbjct: 89 SVKRNKVCLKGGLATPVGGGVSSLNMQ----LRKELDIFASLVNC--------INVPGLV 136
Query: 123 EYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQNPP 182
+ D VV+RE G Y G E GV + + +RI R A A N
Sbjct: 137 TRHENVDIVVIRENTEGEYSGLEHEVV-PGVVESLKVITKFCSERIARYAFEYAYLNNRK 195
Query: 183 LPIWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVVI 241
+ ++ KAN++ + L+ ++ E K + +T ++D+ M LV P + + V++
Sbjct: 196 -KVTAVHKANIMKLADGLFLESCREVAK-HYSGITYNEIIVDNCCMQLVAKPEQFD-VMV 252
Query: 242 TNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPANKVNPIA 301
T N++G++I++ A+ I + G G+ + K NP+A
Sbjct: 253 TPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQ-GASAGNVGNDKMVEQKKANPVA 311
Query: 302 TILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAIAKAVK 358
+LS+AMML+ L LE AV+ V+ G RT DLGG +T EV DA+ A++
Sbjct: 312 LLLSSAMMLR-HLRFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368
>At2g17130 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 367
Score = 80.1 bits (196), Expect = 5e-15
Identities = 94/351 (26%), Positives = 155/351 (43%), Gaps = 30/351 (8%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEAS 64
+ ++PGD VG VT+ +V+ A+ P F+ H LP+ LE+
Sbjct: 40 VTLIPGDGVGPLVTNAVQQVMEAMHA--PVYFEPFEVH--------GDMKSLPEGLLESI 89
Query: 65 KKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKPEY 124
KK L G + P G + + +RKEL L+A+L C P
Sbjct: 90 KKNKVCLKGGLKTPVGGGVSSLN----VNLRKELDLFASLVNC--------FNLPGLASR 137
Query: 125 AKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQNPPLP 184
+ D VV+RE G Y G E GV + + +RI + A A N
Sbjct: 138 HENVDIVVIRENTEGEYAGLEHEVV-PGVVESLKVITKFCSERIAKYAFEYAYLNNRK-K 195
Query: 185 IWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVVITN 243
+ ++ KAN++ + L+ ++ +E K ++P + ++D+ M LV P + + V++T
Sbjct: 196 VTAVHKANIMKLADGLFLESCQEVAK-KYPSIAYNEIIVDNCCMQLVARPEQFD-VMVTP 253
Query: 244 NMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPANKVNPIATI 303
N++G+++++ A+ I + G G NP+A +
Sbjct: 254 NLYGNLVANTAAGIAGGTGVMPGGNVGAEYAVFEQ-GASAGNVGKDTTEEQKNANPVALL 312
Query: 304 LSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
LS+AMML+ L LE AV+ V+ G RT DLGG+++T EV DA+
Sbjct: 313 LSSAMMLR-HLQFPSFADRLETAVKRVIAEGNCRTEDLGGNSTTQEVVDAV 362
>Hs5901982 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 385
Score = 76.3 bits (186), Expect = 7e-14
Identities = 84/348 (24%), Positives = 159/348 (45%), Gaps = 31/348 (8%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEAS 64
+ +LPGD VG E+ +V A A + FQ H + A+ L ++ L +
Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAA-----VPVEFQEHHLSEVQNMASEEKL-EQVLSSM 104
Query: 65 KKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKPEY 124
K+ ++G + P G + +++R++L L+AN+ P
Sbjct: 105 KENKVAIIGKIHTPMEYKGELASYD--MRLRRKLDLFANV--------VHVKSLPGYMTR 154
Query: 125 AKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQNPPLP 184
D V++RE G Y + + GV + + + QRI + A A ++
Sbjct: 155 HNNLDLVIIREQTEGEY-SSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRG-K 212
Query: 185 IWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVVITN 243
+ ++ KAN++ L+ + EE + +P++ + +ID+ M LV++P + + V++
Sbjct: 213 VTAVHKANIMKLGDGLFLQCCEEVAEL-YPKIKFETMIIDNCCMQLVQNPYQFD-VLVMP 270
Query: 244 NMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYE--PCHGSAPDLPANKVNPIA 301
N++G+II + A+ + + + ++E H A + N NP A
Sbjct: 271 NLYGNIIDNLAAGLVGGAGVVPGESY------SAEYAVFETGARHPFAQAVGRNIANPTA 324
Query: 302 TILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTE 348
+LSA+ ML+ L+L + +AV+ V+ G VRT D+GG ++TT+
Sbjct: 325 MLLSASNMLR-HLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTD 371
>CE08620 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 379
Score = 75.9 bits (185), Expect = 9e-14
Identities = 89/357 (24%), Positives = 163/357 (44%), Gaps = 36/357 (10%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEAS 64
+ ++PGD VG E+ + + ++ + + I + + T + + A+E+
Sbjct: 45 VTIIPGDGVGPEL-------IYTVQDIVKQTGIPIEFEEIFLSEVHYTRSSSIENAVESI 97
Query: 65 KKADAVLLGAVGGPKWGTGAVRPE---QGL-LKIRKELGLYANLRPCNFAXXXXXXXXPL 120
+ + V A+ G + + E QGL +++R+ L L+AN+ +
Sbjct: 98 GRNNNV---ALKGAIEESAVLHTEGELQGLNMRLRRSLDLFANV-------VHIKTLDGI 147
Query: 121 KPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQN 180
K + K DFV+VRE G Y + + GV + + + +RI + A A +
Sbjct: 148 KTRHGKQLDFVIVREQTEGEY-SSLEHELVPGVIECLKISTRTKAERIAKFAFDYATKTG 206
Query: 181 PPLPIWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGV 239
+ ++ KAN++ L+ +T E K ++P++ + +ID+ M LV P + + V
Sbjct: 207 RK-KVTAVHKANIMKLGDGLFLRTCEGVAK-QYPKIQFESMIIDNTCMQLVSKPEQFD-V 263
Query: 240 VITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEP--CHGSAPDLPANKV 297
++ N++G+II + A+ + + F ++EP H + +
Sbjct: 264 MVMPNLYGNIIDNLAAGL------VGGAGVVPGQSVGRDFVIFEPGSRHSFQEAMGRSIA 317
Query: 298 NPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
NP A IL AA ML L L G +L +AV +V+ G VRT DLGG +T + DA+
Sbjct: 318 NPTAMILCAANMLN-HLHLDAWGNSLRQAVADVVKEGKVRTRDLGGYATTVDFADAV 373
>CE00970 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 380
Score = 73.6 bits (179), Expect = 4e-13
Identities = 84/348 (24%), Positives = 153/348 (43%), Gaps = 35/348 (10%)
Query: 4 NIVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEA 63
N+ VLPGD +G E+ ++L+A+ + +F+ ++ + + L EA+ A
Sbjct: 53 NVTVLPGDGIGPEMLHHVERILSAV-----QAPVDFE--VVNLTSKEDASEDLA-EAITA 104
Query: 64 SKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXPLKPE 123
K+ L G + V L++R++L LYAN+ C+ P P
Sbjct: 105 IKRNGVALKGNIETKFDNPSFVSRN---LELRRQLNLYANVLHCS--------TIPTVPS 153
Query: 124 YAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSV---PEVQRITRMAAFLALQQN 180
G D V++RE G Y G E E V + ++ITR A F ++
Sbjct: 154 RHTGIDMVIIRENTEGEYSGNEHEAVNAPHPRVVESLKVVTREKSEQITRFA-FQFAKKY 212
Query: 181 PPLPIWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGV 239
+ ++ KAN+ L+ K + K E+P + ++D+A+M LV P + + V
Sbjct: 213 GRKKVTAVHKANIQKLGDGLFLKVATDIAKAEYPDIEFNAMIVDNASMQLVSRPQQFD-V 271
Query: 240 VITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPANK--V 297
++ N++G+IIS+ A + + + + ++E + A K
Sbjct: 272 MLMPNLYGNIISNIACGL------VGGPGLVSGMNIGEDYAVFETGTRNTGTTLAGKDLA 325
Query: 298 NPIATILSAAMMLKLSLDLVEEGRALEEAV-RNVLDAGVRTGDLGGSN 344
NP A I +A ML+ L L + +++ R ++D + T D+GG++
Sbjct: 326 NPTAFIRAAVDMLRF-LGLQSHADMISDSLFRTLVDKRIHTADIGGTS 372
>SPAC11G7.03 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 356
Score = 72.0 bits (175), Expect = 1e-12
Identities = 89/365 (24%), Positives = 160/365 (43%), Gaps = 40/365 (10%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPD---EAL 61
+ ++PGD +G+E + NA+ E+ + I ++ D EA+
Sbjct: 23 VTLIPGDGIGRETS-------NAVTEIFKTANVPIEFEEIDVTGMEKNNKSSGDALHEAI 75
Query: 62 EASKKADAVLLGAVGGP--KWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXXXXXP 119
++ K+ L G + P K G + + +RKEL +YA+L P
Sbjct: 76 QSLKRNKVGLKGILFTPFEKGGHTSFN-----VALRKELDIYASL--------VLIKNIP 122
Query: 120 LKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQ 179
DF ++RE G Y G + GV + + + +RI + A ALQ
Sbjct: 123 GFKTRHDNVDFAIIRENTEGEYSGLEHQSV-PGVVESLKIITEYKSKRIAQFAFDFALQ- 180
Query: 180 NPPLPIWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNG 238
N + + KAN++ + L+R+T + + + +T + ++D+A+M V P + +
Sbjct: 181 NGRKSVTCIHKANIMKLADGLFRRTFYD-VANGYDAITPKDLIVDNASMQAVSRPQQFD- 238
Query: 239 VVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEP-C-HGSAPDLPANK 296
V++ N++G I+S+ S + + + + L+EP C H +
Sbjct: 239 VLVMPNLYGSILSNIGSALVGGPGVIPGA------NFGRDYALFEPGCRHVGLSITGRGE 292
Query: 297 VNPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAIAK 355
NP A ILSA +ML+ L L + + A +V++ G T DLGGS ST + AI +
Sbjct: 293 ANPTAAILSACLMLR-HLGLKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILE 351
Query: 356 AVKEI 360
++ +
Sbjct: 352 RMESL 356
>7301367 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 393
Score = 70.5 bits (171), Expect = 4e-12
Identities = 68/265 (25%), Positives = 120/265 (44%), Gaps = 21/265 (7%)
Query: 94 IRKELGLYANLRPCNFAXXXXXXXXPLKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGV 153
IR EL LY N+ C P P D V++R+ G Y + + G+
Sbjct: 138 IRNELDLYVNVVHCK--------SYPGIPARHHDIDVVLIRQNTDGEY-AMLEHESVPGI 188
Query: 154 AWDSEKYSVPEVQRITRMAAFLALQQNPPLPIWSLDKANVLASSRLWRKTVEETIKTEFP 213
+ +V +R+ R A F +QN + ++ KAN++ S V + ++P
Sbjct: 189 VESMKVVTVENAERVARYA-FEFARQNNRKKVTTIHKANIMKLSDGLFLEVANRVHKDYP 247
Query: 214 QLTVQHQLIDSAAMILVKSPTKLNGVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXX 273
+L + +ID+ M V +P + + V+ N++G I+S +V+
Sbjct: 248 ELEHNNMIIDNTCMQSVSNPHQFD-VMNMTNLYGTIVS---NVLCGLMGGAGLISGRNYG 303
Query: 274 DTNKAFGLYEPCHGSAPDLPANK--VNPIATILSAAMMLKLSLDLVEEGRALEEAV-RNV 330
D + ++EP + A K NP+A I ++ ML L E ++EAV + +
Sbjct: 304 D---HYAIFEPGTRNTGTAIAGKNIANPVAMISASIDMLN-HLGHKEHANVIQEAVYQTI 359
Query: 331 LDAGVRTGDLGGSNSTTEVGDAIAK 355
++ +RT D+GG+NS+T+V + I K
Sbjct: 360 VNDAIRTPDIGGTNSSTDVVENILK 384
>7300799 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 370
Score = 69.3 bits (168), Expect = 8e-12
Identities = 81/352 (23%), Positives = 156/352 (44%), Gaps = 33/352 (9%)
Query: 7 VLPGDHVGKEVTDEAIKVLNAIAEVRPEIKFNFQHHLIGGAAIDATGTPLPDEALEASKK 66
++PGD VG E+ +V A + + +F+ + + + I+ + ++ + + +K
Sbjct: 42 LIPGDGVGPELVYSLQEVFKAAS-----VPVDFECYFL--SEINPVLSAKLEDVVASIQK 94
Query: 67 ADAVLLGAVGGPKWGTGAVRPEQGL-LKIRKELGLYANLRPCNFAXXXXXXXXPLKPEYA 125
+ G + P + V Q L +K+R +L LYAN+ P
Sbjct: 95 NKVCIKGVLATPDYSN--VGDLQTLNMKLRNDLDLYANV--------VHVRSLPGVKTRH 144
Query: 126 KGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFLALQQNPPLPI 185
D V++RE G Y E G+ + + + RI + A F +N +
Sbjct: 145 TNIDTVIIREQTEGEYSALEHESV-PGIVECLKIITAKKSMRIAKFA-FDYATKNQRKKV 202
Query: 186 WSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKLNGVVITNN 244
++ KAN++ L+ ++ EE + +P++ + ++D+ M +V +P + + V++T N
Sbjct: 203 TAVHKANIMKLGDGLFLRSCEEVSRL-YPRIQFEKMIVDNTTMQMVSNPNQFD-VMVTPN 260
Query: 245 MFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEP--CHGSAPDLPANKVNPIAT 302
++G I+ + AS + ++EP H A + N NP A
Sbjct: 261 LYGAIVDNLASGLVGGAGVVAGASYSSES------VVFEPGARHTFAEAVGKNVANPTAM 314
Query: 303 ILSAAMMLKLSLDLVEEGRALEEAVRNVLDAG-VRTGDLGGSNSTTEVGDAI 353
+L +L+ ++L G ++ A+ VL+ G VRT DLGG ++T + AI
Sbjct: 315 LLCGVKLLR-HINLPTYGEIIQNAINKVLNDGKVRTKDLGGQSTTQDFTRAI 365
>CE16887 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 373
Score = 67.8 bits (164), Expect = 2e-11
Identities = 84/370 (22%), Positives = 163/370 (43%), Gaps = 53/370 (14%)
Query: 5 IVVLPGDHVGKEVTDEAIKVLNAIAEVRPEIKF-----NFQHHLIGGAAIDATGTPLPDE 59
+ LPGD +G E+ IA +R F NF+ + + +D D
Sbjct: 38 VCALPGDGIGPEM----------IAHIRNIFSFCHAPVNFEEVQVSSSLLDGD----MDA 83
Query: 60 ALEASKKADAVLLGAV----GGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFAXXXXX 115
A+ A ++ + G + P++ + V ++R +L LYAN+ C
Sbjct: 84 AMLAIERNGVAIKGNIETKHDDPQFNSRNV-------ELRTKLDLYANILHC-------- 128
Query: 116 XXXPLKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGVAWDSEKYSVPEVQRITRMAAFL 175
P P G D V++RE G Y G E G+ + + +++RI+RMA F
Sbjct: 129 VTIPTVPTRHSGIDIVLIRENTEGEYSGLEHEAV-PGIVESIKIVTREKIERISRMA-FE 186
Query: 176 ALQQNPPLPIWSLDKANVLA-SSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPT 234
+ N + ++ KAN+ L+ K V + + ++ + + ++D+A+M LV P
Sbjct: 187 YAKANGRKKVTAVHKANIQKLGDGLFLKVVRD-MSEDYKDIKFEAMIVDNASMQLVSKPQ 245
Query: 235 KLNGVVITNNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNKAFGLYEPCHGSAPDLPA 294
+ + V++ N++G+IIS+ A + + + ++E + A
Sbjct: 246 QFD-VMVMPNLYGNIISNIACGLVGGPGLVSGM------NLGDKYAVFETGTRNTGTSLA 298
Query: 295 NK--VNPIATILSAAMMLKLSLDLVEEGRALEEAV-RNVLDAGVRTGDLGGSNSTTEVGD 351
K NP A I ++ ML+ L + +A+ + +++ + T D+GG+NS ++V +
Sbjct: 299 GKDIANPTAFIRASVDMLRY-LGCHYHANIISDALWKALVEQRIHTADIGGNNSASDVIN 357
Query: 352 AIAKAVKEIL 361
A + +K ++
Sbjct: 358 ATLQNIKVLM 367
>Hs4758582 [E] KOG0784 Isocitrate dehydrogenase gamma subunit
Length = 393
Score = 62.4 bits (150), Expect = 1e-09
Identities = 65/273 (23%), Positives = 122/273 (43%), Gaps = 27/273 (9%)
Query: 94 IRKELGLYANLRPCNFAXXXXXXXXPLKPEYAKGTDFVVVRELVGGIYFGERKEDEGDGV 153
+R L LYAN+ C P K D ++VRE G Y E + V
Sbjct: 135 LRTSLDLYANVIHCK--------SLPGVVTRHKDIDILIVRENTEGEY----SSLEHESV 182
Query: 154 AWDSEKYSVPEVQRITRMA--AFLALQQNPPLPIWSLDKANVLA-SSRLWRKTVEETIKT 210
A E + + R+A AF Q++ + ++ KAN++ L+ + E +
Sbjct: 183 AGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCRE-VAA 241
Query: 211 EFPQLTVQHQLIDSAAMILVKSPTKLNGVVITNNMFGDIISDEASVIXXXXXXXXXXXXX 270
+PQ+T ++ ++D+ M LV P + + V++ N++G+I+++ + +
Sbjct: 242 RYPQITFENMIVDNTTMQLVSRPQQFD-VMVMPNLYGNIVNNVCAGL------VGGPGLV 294
Query: 271 XXXDTNKAFGLYEPCHGSAPDLPANK--VNPIATILSAAMMLKLSLDLVEEGRALEEAVR 328
+ + ++E + ANK NP AT+L++ MML L L ++ +AV
Sbjct: 295 AGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLD-HLKLHSYATSIRKAVL 353
Query: 329 NVLD-AGVRTGDLGGSNSTTEVGDAIAKAVKEI 360
+D + T D+GG +T+E + + ++ I
Sbjct: 354 ASMDNENMHTPDIGGQGTTSEAIQDVIRHIRVI 386
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.135 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,603,709
Number of Sequences: 60738
Number of extensions: 775340
Number of successful extensions: 1360
Number of sequences better than 1.0e-05: 26
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 1272
Number of HSP's gapped (non-prelim): 29
length of query: 362
length of database: 30,389,216
effective HSP length: 108
effective length of query: 254
effective length of database: 23,829,512
effective search space: 6052696048
effective search space used: 6052696048
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)